Pulmonary Disease malady

Wikipedia: Respiratory disease is a medical term that encompasses pathological conditions affecting the organs and...⁴⁴ more...

MalaCards: Pulmonary Disease, also known as lung diseases, is related to carcinoma and fibrosis. An important gene associated with Pulmonary Disease is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are NFAT in Immune Response and eNOS Signaling. The compounds serine and salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are no phenotypic analysis and normal.

pulmonary disease 7 lung diseases 43

Diseases related to pulmonary disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 940)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	94.3	PIK3CG, PIN1, PI3, PIM1, LRP5, LRP6
2	fibrosis	76.3	PIK3CG, PIN1, PI3, NCF2, NCOA3, PDE4A
3	pancreatitis	76.2	PIK3CG, PIN1, PI3, PIM1, LRP5, NCF2
4	adenocarcinoma	73.5	PIK3CG, PIN1, PIM1, NCOA3, RET, VWF
5	rheumatoid arthritis	72.2	PIK3CG, PIN1, LRP5, PDE4A, RETN, VWF
6	copd	72.1	PDE4A, VWF, SFTPB, SFTPD, GC, GCLM
7	neuronitis	71.7	PIK3CG, PIN1, PIM1, LRP6, NCF2, PDE4A
8	thyroiditis	68.1	PIK3CG, PIN1, NCOA3, PDE4A, REN, RET
9	atherosclerosis	67.7	PIK3CG, PI3, LRP5, LRP6, NCF2, PDE4A
10	cystic fibrosis	65.6	PIK3CG, PI3, PDE4A, REN, VWF, SFTPA1
11	chronic obstructive pulmonary disease	65.0	PI3, PDE4A, SFTPB, SFTPD, GC, SELPLG
12	hypertension	63.6	PIK3CG, PIM1, LRP5, LRP6, PDE4A, REN
13	multiple sclerosis	63.5	PDE4A, VWF, PCNA, GC, NBN, SELE
14	pneumonia	63.0	PI3, PDE4A, SFTPA1, SFTPB, SFTPC, SFTPD
15	melanoma	62.7	PIK3CG, PI3, PIM1, NCOA3, PDE4A, RET
16	hypoxia	62.5	PIK3CG, PIM1, LRP5, PDE4A, REN, RET
17	ischemia	57.7	PIK3CG, PDE4A, REN, RETN, VWF, PCNA
18	obesity	57.4	PIK3CG, LRP5, NCOA3, REN, RETN, VWF
19	dermatitis	55.0	PI3, PDE4A, SFTPD, SELE, SELL, SELP
20	osteoarthritis	53.9	PIK3CG, LRP5, LRP6, PDE4A, RETN, SERPINA1
21	bronchial asthma	52.6	SFTPD, SELE, SELL, SELP, NAT2, VEGFA
22	insulin resistance	51.4	PIK3CG, REN, RETN, VWF, SFTPA1, RBP4
23	emphysema	50.8	PI3, SFTPB, SFTPC, SFTPD, PCNA, SERPINE2
24	sarcoidosis	50.3	SFTPD, SELE, SELL, SELP, SERPINA3, VEGFA
25	bronchiolitis	50.2	NCF2, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
26	influenza	50.1	PIK3CG, SFTPA1, SFTPD, SELL, SERPINE1, LITAF
27	lung carcinoma	49.5	PIK3CG, SFTPB, SFTPD, PCNA, RBP4, NBN
28	sarcoma	48.8	PIK3CG, NCOA3, PDE4A, REN, RET, VWF
29	leukemia	48.2	ZNF230, PIK3CG, PIN1, PIM1, LRP5, LRP6
30	coronary heart disease	47.9	LRP5, RETN, VWF, SELE, SELL, SELP
31	prostatitis	47.6	PIK3CG, PIN1, PIM1, LRP5, NCOA3, PDE4A
32	gonococcal synovitis	47.3	PIK3CG, PI3, PDE4A, RETN, VWF, SFTPB
33	glomerulonephritis	47.1	REN, VWF, PCNA, RBP4, SELP, SERPINC1
34	aortic aneurysm	47.0	LRP5, REN, RETN, VWF, SELE, SELL
35	pulmonary fibrosis	46.6	NCF2, VWF, SFTPA1, SFTPB, SFTPC, SFTPD
36	blindness	46.2	PIK3CG, LRP5, PDE4A, REN, VWF, RBP4
37	myopathy	44.7	SELE, VCAM1, MYOG, MYF5, MYOD1, BCL2
38	atopy	44.2	SELP, NAT2, VEGFA, VDR, BCL6, SCGB1A1
39	lung adenocarcinoma	43.1	PIK3CG, VWF, SFTPB, SFTPC, SFTPD, PCNA
40	asthma	41.3	GCLM, SERPINE1, SCGB1A1, MPO, CD14, IL12B
41	interstitial lung disease	40.7	SFTPB, SFTPC, SFTPD, BMP6, ITGAM, IL13RA2
42	atopic dermatitis	40.6	PDE4A, SELE, SELL, SELP, NAT2, VCAM1
43	dermatomyositis	40.3	VWF, SFTPD, SELE, SERPINA3, VEGFA, VCAM1
44	cystic fibrosis lung disease	40.1	SERPINA1, SCGB1A1, MUC5AC, MUC5B, CFTR, FUT2
45	aldosteronism	39.8	PIK3CG, REN, RETN, SERPINE2, SERPINE1, NAMPT
46	alpha 1-antitrypsin deficiency	39.6	PIM1, SFTPB, GC, SERPINE2, SERPINC1, SERPINI1
47	allergic asthma	39.6	PCNA, SERPINE1, VCAM1, BMP6, BCL2, SCGB1A1
48	eosinophilia	39.1	PDE4A, REN, SFTPA1, SFTPD, SELL, SERPINA1
49	respiratory failure	38.8	REN, SFTPB, SFTPC, SFTPD, RBP4, SERPINC1
50	osteoporosis	38.8	LRP5, LRP6, PDE4A, GC, RBP4, SELE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pulmonary disease:

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MGI Mouse Phenotypes related to pulmonary disease:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	INF	LRP6, RET, SFTPC, PCNA, RB1CC1, SERPINE2
2	normal phenotype	MP:0002873	INF	LRP5, LRP6, REN, RET, PCTP, BTC
3	behavior/neurological phenotype	MP:0005386	INF	LRP5, LRP6, NCOA3, REN, SFTPB, SFTPC
4	pigmentation phenotype	MP:0001186	INF	LRP5, SERPINC1, BRCA1, MYC, MYO5A, RAG1
5	liver/biliary system phenotype	MP:0005370	INF	LRP5, LRP6, NCOA3, RETN, PCTP, RB1CC1
6	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CG, LRP5, LRP6, NCOA3, REN, RET
7	digestive/alimentary phenotype	MP:0005381	INF	LRP6, NCOA3, RET, VWF, BRCA1, BRCA2
8	reproductive system phenotype	MP:0005389	INF	LRP6, NCOA3, REN, RET, SFTPC, RBP4
9	embryogenesis phenotype	MP:0005380	INF	LRP5, LRP6, NCOA3, RET, NBN, SERPINC1
10	tumorigenesis	MP:0002006	INF	NCOA3, RET, SFTPC, NBN, SELL, SERPINE1
11	muscle phenotype	MP:0005369	INF	PIK3CG, NCOA3, REN, RET, BTC, RBP4
12	renal/urinary system phenotype	MP:0005367	INF	LRP6, NCOA3, REN, RET, SELP, SELPLG
13	endocrine/exocrine gland phenotype	MP:0005379	14.2	LRP5, RET, NBN, SELL, SERPINE2, BRCA1
14	craniofacial phenotype	MP:0005382	14.0	LRP5, LRP6, NCOA3, NBN, MYO5A, RARG
15	hearing/vestibular/ear phenotype	MP:0005377	12.6	LRP6, NCOA3, VDR, MYC, MYO5A, MYO1A
16	other phenotype	MP:0005395	12.4	MYF5, RARG, SCNN1G, LEPR, LDLR, MSR1
17	limbs/digits/tail phenotype	MP:0005371	INF	LRP5, LRP6, RET, SEPP1, BRCA1, BRCA2
18	skeleton phenotype	MP:0005390	INF	PIK3CG, LRP6, GC, BTC, BRCA1, BRCA2
19	nervous system phenotype	MP:0003631	INF	LRP5, LRP6, PDE4A, REN, VWF, NBN
20	immune system phenotype	MP:0005387	INF	LRP5, NCOA3, PDE4A, REN, VWF, PCTP
21	respiratory system phenotype	MP:0005388	INF	LRP6, RET, SFTPC, SFTPD, SELL, SELP
22	adipose tissue phenotype	MP:0005375	INF	LRP6, NCOA3, RETN, SERPINE1, BRCA1, LPL
23	vision/eye phenotype	MP:0005391	INF	PIN1, LRP5, LRP6, SFTPC, RBP4, SELE
24	cellular phenotype	MP:0005384	INF	PIK3CG, PIN1, PIM1, LRP5, LRP6, NCOA3
25	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, LRP6, NCOA3, RB1CC1, SELP
26	mortality/aging	MP:0010768	INF	LRP5, LRP6, REN, RET, VWF, SFTPB
27	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, LRP5, PDE4A, REN, RET, VWF
28	hematopoietic system phenotype	MP:0005397	INF	PIM1, PCNA, RB1CC1, NBN, SERPINB1, BRCA1
29	growth/size phenotype	MP:0005378	INF	PIK3CG, PIN1, PIM1, LRP6, NCOA3, REN

Articles related to pulmonary disease:

(show top 50)    (show all 695)

id	Title	Authors	Year	Affiliating Genes
1	Elevated serum adiponectin level in patients with Myc obacterium avium-intracellulare complex pulmonary disease. (19641295)	Tasaka S.... Ishizaka A.	2010	TNF
2	The cyclooxygenase-2-765C promoter polymorphism prote cts against the development of chronic obstructive pulmonary disease. (20724130)	Wu L.... Black P.N.	2010	PTGS2
3	Expression of high-mobility group box 1 and of recept or for advanced glycation end products in chronic obstructive pulmonary disease . (20133931)	Ferhani N.... Pretolani M.	2010	HMGB1
4	Association between interleukin-8 in lung tissues an d stages of chronic obstructive pulmonary diseases (19950606)	Hu X.R.... Wen F.Q.	2009	IL8
5	Combined nutritional support in patients with chronic obstructive pulmonary disease (COPD), under mechanical ventilation (MV). (20214203)	Grigorakos L.... Baltopoulos G.	2009	ALB
6	alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies. (19426146)	Ekeowa U.I.... Lomas D.A.	2009	SERPINI1
7	Glucocorticoid sensitivity of lipopolysaccharide-stim ulated chronic obstructive pulmonary disease alveolar macrophages. (19737233)	Armstrong J.... Singh D.	2009	CSF2, CSF3
8	Association of Interleukin (IL)-12 and IL-27 Gene Polymorphisms with Chronic Obstructive Pulmonary Disease in a Chinese Population. (18554158)	Huang N.... Yang X.D.	2008	IL12A, IL27
9	Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. (18258629)	Hopkinson N.S.... Polkey M.I.	2008	VDR, ACE, BDKRB2
10	Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. (18364273)	Hsieh M.H.... Christiani D.C.	2008	TNF, IL6, IL1B
11	Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. (18424749)	Nakao I.... Izuhara K.	2008	MUC5AC, SLC26A4
12	Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study. (19124359)	Kunisaki K.M.... Niewoehner D.E.	2008	IL6, IL8, CRP
13	Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population. (18853286)	Ning Y.... Wen F.	2008	AQP5
14	Changes of anaphylatoxin C5a in chronic obstructive pulmonary disease and the relationship with systemic and local inflammation]. (18953960)	Zhang J.... Sun Y.C.	2008	C5
15	Mycobacterium alsiense, a novel, slowly growing species isolated from two patients with pulmonary disease. (17804654)	Richter E.... Kristiansen J.E.	2007	HSPD1
16	Association of tumor necrosis factor alpha 308 G/A gene promoter polymorphism with the presence of chronic obstructive pulmonary disease: a meta-analysis (17988552)	Hu G.P.... Ran P.X.	2007	TNF
17	Comparison of B-type natriuretic peptide assays for identifying heart failure in stable elderly patients with a clinical diagnosis of chronic obstructive pulmonary disease. (17347037)	Rutten F.H.... Hoes A.W.	2007	NPPB
18	Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis. (17395501)	Kraus V.B.... Jordan J.M.	2007	CRP
19	Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease. (16787174)	Ricciardolo F.L.... Folkerts G.	2006	NOS2
20	Titin and diaphragm dysfunction in chronic obstructive pulmonary disease. (16339921)	Ottenheijm C.A.... Dekhuijzen P.N.	2006	TTN
21	Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease (16945263)	Izquierdo J.L.... PAcrez J.	2006	IL8
22	Pathophysiology of exacerbations of chronic obstructive pulmonary disease. (16636093)	Papi A.... Fabbri L.M.	2006	ICAM1, TNF, IL8
23	A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease. (16002569)	Takabatake N.... Kubota I.	2005	PLA2G2D, PLA2G10
24	Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. (16267352)	Belmonte K.E.	2005	CHRM2, CHRM3, PDE4A
25	Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases (15612581)	Ianbaeva D.G.... Viktorova T.V.	2004	SERPINA1, MMP1, SERPINA3
26	STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. (15293608)	Di Stefano A.... Adcock I.M.	2004	STAT4
27	Surfactant protein B 1580 polymorphism is associated with susceptibility to chronic obstructive pulmonary disease in Chinese Han population. (15315329)	Hu R.... Zhang Z.	2004	SFTPB
28	Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China. (15498369)	Zhou M.... Li M.	2004	MMP9
29	Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. (15001333)	Barnes P.J.... Adcock I.M.	2004	HDAC2
30	Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease. (15526813)	Tsantes A.E.... Loukopoulos D.	2004	EPO
31	Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters (15266830)	Li L.... Chen Y.	2004	ELANE, PTGER1
32	Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. (15271696)	Itoh T.... Kimura H.	2004	IL6
33	The role of matrix metalloproteinases-9 and tissue inhibitor of metalloproteinaes-1 in chronic obstructive pulmonary disease (12921631)	Xu X.M.... Zhang H.S.	2003	MMP9, TIMP1
34	Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors. (14656045)	Cataldo D.D.... Foidart J.M.	2003	MMP2, MMP9, MMP12
35	Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. (12654609)	Sin D.D.... Man S.F.	2003	CRP
36	Cytokines and dietary energy restriction in stable chronic obstructive pulmonary disease patients. (14680079)	Godoy I.... Paiva S.A.	2003	TNF
37	Etiology, pathogenesis and management of senile inflammatory pulmonary diseases (11925914)	Yamaya M.... Sasaki H.	2002	HMOX1
38	Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. (14561194)	Rahman I.	2002	MAPK1, MAPK8, JUN
39	CFTR gene mutations--including three novel nucleotide substitutions--and haplotype background in patients with asthma, disseminated bronchiectasis and chronic obstructive pulmonary disease. (11354633)	Tzetis M.... Kanavakis E.	2001	CFTR
40	CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (11580851)	Jones D.C.... Bunce M.	2001	CD1D, CD1A, CD1B
41	Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. (11179105)	Aaron S.D.... Dales R.E.	2001	MPO
42	Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1. (10639528)	Yim J.J.... Yoo C.G.	2000	EPHX1
43	Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis. (10391871)	Lein A.D.... Andersen P.	1999	IFNG
44	Cytochrome oxidase activity and mitochondrial gene expression in skeletal muscle of patients with chronic obstructive pulmonary disease. (9603116)	Sauleda J.... Agusti A.G.	1998	COX5A, MT-CO1
45	Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies. (9460300)	Martinez J.A.... Jardim J.R.	1997	TF, F3
46	Plasma levels of atrial natriuretic peptide and brain natriuretic peptide following intravenous saline infusion in oedematous chronic obstructive pulmonary disease and non-oedematous chronic obstructive pulmonary disease. (8933657)	Sheedy W.... Morice A.H.	1996	NPPB, NPPA
47	A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. (7521937)	Highsmith W.E.... Silverman L.M.	1994	CFTR
48	Endothelins and pulmonary diseases. (7836103)	Barnes P.J.	1994	EDN1
49	Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease. (8393399)	Piperno D.... Perrin-Fayolle M.	1993	NPPA
50	Reversal of sexual impotence in male patients with chronic obstructive pulmonary disease and hypoxemia with long-term oxygen therapy. (8274414)	AasebA... rdal L.	1993	SHBG

Genes related to pulmonary disease according to GeneCards:

(show top 50)    (show all 718)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.1	Publications, Summaries
2	COPD	Pulmonary disease, chronic obstructive, severe early-onset	11.0	Aliases & Descriptions, Publications
3	TSLP	thymic stromal lymphopoietin	11.0	Publications, Summaries
4	HHIP	hedgehog interacting protein	11.0	Summaries
5	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	11.0	Publications, Summaries
6	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0	Summaries, Publications
7	COPD13	Chronic obstructive pulmonary disease QTL 13	11.0	Publications, Aliases & Descriptions
8	COPD6	Chronic obstructive pulmonary disease QTL 6	11.0	Aliases & Descriptions, Publications
9	COPD11	Chronic obstructive pulmonary disease QTL 11	11.0	Publications, Aliases & Descriptions
10	COPD8	Chronic obstructive pulmonary disease QTL 8	11.0	Publications, Aliases & Descriptions
11	COPD16	Chronic obstructive pulmonary disease QTL 16	11.0	Publications, Aliases & Descriptions
12	COPD25	Chronic obstructive pulmonary disease QTL 25	11.0	Aliases & Descriptions
13	COPD24	Chronic obstructive pulmonary disease QTL 24	11.0	Aliases & Descriptions
14	COPD26	Chronic obstructive pulmonary disease QTL 26	11.0	Aliases & Descriptions
15	COPD5	Chronic obstructive pulmonary disease QTL 5	11.0	Publications, Aliases & Descriptions
16	COPD15	Chronic obstructive pulmonary disease QTL 15	11.0	Publications, Aliases & Descriptions
17	COPD10	Chronic obstructive pulmonary disease QTL 10	11.0	Publications, Aliases & Descriptions
18	COPD17	Chronic obstructive pulmonary disease QTL 17	11.0	Publications, Aliases & Descriptions
19	COPD18	Chronic obstructive pulmonary disease QTL 18	11.0	Aliases & Descriptions, Publications
20	COPD14	Chronic obstructive pulmonary disease QTL 14	11.0	Publications, Aliases & Descriptions
21	COPD20	Chronic obstructive pulmonary disease QTL 20	11.0	Publications, Aliases & Descriptions
22	COPD12	Chronic obstructive pulmonary disease QTL 12	11.0	Publications, Aliases & Descriptions
23	COPD7	Chronic obstructive pulmonary disease QTL 7	11.0	Aliases & Descriptions, Publications
24	COPD9	Chronic obstructive pulmonary disease QTL 9	11.0	Publications, Aliases & Descriptions
25	COPD27	Chronic obstructive pulmonary disease QTL 27	11.0	Aliases & Descriptions
26	COPD28	Chronic obstructive pulmonary disease QTL 28	11.0	Aliases & Descriptions
27	COPD29	Chronic obstructive pulmonary disease QTL 29	11.0	Aliases & Descriptions
28	COPD19	Chronic obstructive pulmonary disease QTL 19	11.0	Aliases & Descriptions, Publications
29	COPD21	Chronic obstructive pulmonary disease QTL 21	11.0	Publications, Aliases & Descriptions
30	COPD1	Chronic obstructive pulmonary disease QTL 1	11.0	Aliases & Descriptions, Publications
31	COPD2	Chronic obstructive pulmonary disease QTL 2	11.0	Aliases & Descriptions, Publications
32	COPD4	Chronic obstructive pulmonary disease QTL 4	11.0	Aliases & Descriptions, Publications
33	COPD3	Chronic obstructive pulmonary disease QTL 3	11.0	Aliases & Descriptions, Publications
34	COPD23	Chronic obstructive pulmonary disease QTL 23	11.0	Aliases & Descriptions, Publications
35	COPD22	Chronic obstructive pulmonary disease QTL 22	11.0	Aliases & Descriptions, Publications
36	DNTTIP2	deoxynucleotidyltransferase, terminal, interacting protein 2	11.0	Summaries
37	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
38	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
39	GPR182	G protein-coupled receptor 182	11.0	Publications
40	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
41	SFTPD	surfactant protein D	11.0	Publications
42	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	11.0	Publications
43	CCR8	chemokine (C-C motif) receptor 8	11.0	Publications
44	CLCA1	chloride channel accessory 1	11.0	Publications
45	DEFB1	defensin, beta 1	11.0	Publications
46	GLRX	glutaredoxin (thioltransferase)	11.0	Publications
47	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
48	SFTPB	surfactant protein B	11.0	Publications
49	ADAM33	ADAM metallopeptidase domain 33	11.0	Publications
50	SOD3	superoxide dismutase 3, extracellular	11.0	Publications

Pathways related to pulmonary disease according to GeneDecks:

(show top 50)    (show all 175)

id	Pathway	Score	Top Affiliating Genes
1	NFAT in Immune Response36	INF	BTC, BMP6, UTS2, CHUK, JUN, CD79A
2	eNOS Signaling36	INF	BTC, BMP6, UTS2, BDKRB2, CHRNA3,
3	p70S6K Signaling36	INF	BTC, BMP6, RAC1, UTS2, IRS1, FLT1
4	Endothelin-1 Signaling Pathway36	INF	MYC, BMP6, CD80, FLT1, INSR, IL10
5	Pancreatic Adenocarcinoma36	INF	BTC, BRCA2, BMP6, RAC1, UTS2, BCL2
6	MIF Mediated Glucocorticoid Regulation36	15.9	BMP6, BCL2, BAX, CD14, CD80, IL10
7	all-trans-Retinoic Acid Signaling in Brain36	15.6	BMP6, RARG, BCL2, BAX, CD80, IL10
8	IL-6 Pathway36	15.1	PIM1, BMP6, BAX, CD80, IL10, IL11
9	Influenza A20	14.2	PIK3CG, MX1, JUN, IRF3, GSK3B, IL12A
10	Toxoplasmosis20	14.0	PIK3CG, BIRC3, BCL2, CHUK, LDLR, CD40
11	Toll-like receptor signaling pathway20	13.9	PIK3CG, RAC1, CHUK, LBP, JUN, CD86
12	PGC1Alpha Pathway36	13.7	BMP6, BCL2, BAX, CD4, CD80, INSR
13	SOCS Pathway36	13.6	BMP6, BCL2, BAX, CD4, CD80, IRS1
14	Pertussis20	13.6	SFTPA1, JUN, CD14, ITGAM, ITGB2, FOS
15	NFAT Signaling and Lymphocyte Interactions36	12.6	BMP6, BCL2, BAX, CD4, CD80, IL11
16	Jak-STAT signaling pathway20	12.5	PIK3CG, PIM1, MYC, LEP, LEPR, IL10
17	Immune response MIF-mediated glucocorticoid regulation10	12.4	VCAM1, CHUK, JUN, MMP1, FOS, IL2
18	Cell adhesion ECM remodeling10	12.2	SERPINE2, SERPINE1, VCAN, MMP1, MMP12, MMP14
19	Cell adhesion_ECM remodeling41	12.1	SERPINE2, SERPINE1, VCAN, MMP1, MMP12, MMP14
20	Immune response_Bacterial infections in normal airways41	11.8	CHUK, LBP, CFTR, CD14, IRF1, IL1B
21	Bacterial infections in CF airways41	11.8	SFTPA1, SFTPD, CHUK, LBP, CFTR, IRF1
22	Measles20	11.8	PIK3CG, CHUK, MX1, CDKN1B, CDK4, IRF3
23	Th1 Differentiation37	11.5	JUN, CD86, CD4, CD80, FOS, IL10
24	DNA Repair Mechanisms36	11.5	PCNA, BRCA1, BRCA2, RAD51, RAD23B, LIG3
25	p53 Signaling36	11.4	BRCA1, BCL2, CHEK1, BAX, ATM, CDKN1A
26	Cell Cycle / Checkpoint Control3	11.0	PIN1, PCNA, NBN, BRCA1, BRCA2, BRIP1
27	Signal transduction AKT signaling10	10.9	IRS1, GSK3B, NFKBIE
28	Development_IGF-1 receptor signaling41	10.7	MYC, CHUK, FOXO3, IRS1, GSK3B, MAPK1
29	Signal transduction_AKT signaling41	10.7	PCNA, MYC, CHUK, BAX, CDKN1A, CDKN1B
30	Development IGF-RI signaling10	10.6	MYC, CHUK, FOXO3, IRS1, MAPK1, CCND3
31	MAPK signaling pathway20	INF	MYC, RAC1, CHUK, JUN, CD14, CDC25B
32	Paxillin Interactions36	INF	BTC, RAC1, UTS2, PAK6, ITGAL, ITGAM
33	Tuberculosis20	INF	VDR, BCL2, BAX, LBP, CEBPB, CD14
34	PPAR Pathway36	INF	BTC, UTS2, ITGAL, ITGAM, ITGB2, FLT1
35	STAT3 Pathway36	INF	PIM1, MYC, BMP6, RAC1, BCL2, BAX
36	PTEN Pathway36	INF	BTC, RAC1, UTS2, ITGAL, ITGAM, ITGB2
37	DHA Signaling36	INF	BTC, BMP6, UTS2, BCL2, BAX, FOXO1
38	Cytokine-cytokine receptor interaction20	INF	VEGFA, LEP, LEPR, CD27, CD40, FLT1
39	Akt Signaling36	INF	PIK3CG, BTC, UTS2, CHEK1, CHUK, CD4
40	Rac1 Pathway36	INF	NCF2, BTC, BMP6, RAC1, UTS2, PAK6
41	Amoebiasis20	INF	SERPINB1, , CD14, CD1D, ITGAM, ITGB2
42	NF-KappaB Family Pathway36	INF	BTC, BMP6, UTS2, CHUK, FLT1,
43	Chagas disease (American trypanosomiasis)20	INF	PIK3CG, SERPINE1, BDKRB2, CHUK, JUN, FOS
44	p53 Mediated Apoptosis36	INF	BTC, BMP6, UTS2, BCL2, CHEK1, BAX
45	Antioxidant Action of Vitamin-C36	INF	NCF2, BTC, MYO5A, MYO1A, BMP6, RAC1
46	Estrogen Pathway36	INF	NCOA3, BTC, BRCA1, BMP6, UTS2, BCL2
47	ERK Signaling36	INF	BTC, MYC, BMP6, UTS2, PAK6, CHUK
48	Glioblastoma Multiforme36	INF	RAC1, FZD7, CDKN1A, CDKN1B, CDK4, FOXO1
49	GPCR Pathway36	INF	BTC, BMP6, RAC1, UTS2, PAK6, CHUK
50	Th17 Differentiation37	INF	CD86, CD4, CD80, IL12B, IL17A, IL17F

Compounds related to pulmonary disease according to GeneDecks:

(show top 50)    (show all 571)

id	Compound	Score	Top Affiliating Genes
1	serine32	INF	PIK3CG, PIN1, , PIM1, PDE4A, RET
2	salicylic acid32	INF	PIK3CG, SERPINA1, VDR, MYC, CHUK, XDH
3	fmlp32	INF	PIK3CG, NCF2, PDE4A, GC, SELL, SELP
4	cisplatin32 34 9 9	INF	PCNA, GCLM, SETD2, BRCA1, BRCA2, VEGFA
5	chloride32	INF	REN, CLCA1, CHAT, CHRM3, MUC5AC, LCN1
6	cyclosporin a32 42	INF	PIK3CG, PIN1, , PDE4A, VWF, SELP
7	inositol32	INF	PDE4A, LPL, BCR, CHRM3, CD79A, INSR
8	thapsigargin32 42	INF	PIK3CG, PCNA, SERPINE1, UTS2, BDKRB2, BCL2
9	leukotriene b432 42 18	INF	PDE4A, GC, SELL, SELP, RAC1, LCN2
10	doxorubicin32 34 9 9	INF	PIK3CG, NBN, SELE, SETD2, BRCA1, BMP6
11	indomethacin32 9 9	INF	PDE4A, REN, PCNA, SELL, LPL, MYC
12	thyroxine32 18	INF	REN, RETN, VWF, PCNA, GC, RBP4
13	phospholipid32	15.1	PDE4A, VWF, SFTPB, SFTPC, SFTPD, PCTP
14	fluticasone propionate32 42 9 9	16.6	SELE, VCAM1, BGLAP, MPO, MMP9, IL13
15	pioglitazone32 9 9	15.5	RETN, RBP4, NAMPT, VEGFA, LPL, VCAM1
16	txb232	13.4	REN, VWF, SELP, IL11, IL1RN, APOH
17	gm-csf32	13.3	VEGFA, BMP6, CD14, IL10, IL11, IL13
18	polyinosinic-polycytidylic acid32	12.9	SELE, VCAM1, CD83, CD40, IRF1, IRF3
19	candesartan32 9 9	14.9	REN, SELP, SERPINE1, VEGFA, BDKRB2, MMP1
20	celecoxib32 42 34 9 18 9	17.8	PIK3CG, REN, PCNA, VEGFA, PARP1, BCL2
21	salmeterol32 42 9 9	15.6	PDE4A, ITGB2, IL13, IL2, IL4, IL5
22	ibuprofen32 9 18 9	15.2	VCAM1, BMP6, LEP, CHUK, CFTR, MMP1
23	methylcellulose32	12.1	CD14, CDH1, FGF2, IL11, IL15, IL1A
24	fluoxetine32 34 9 9	15.0	IL10, F3, HTR1B, HTR2A, AKR1C4, DRD2
25	cyclophosphamide32 34 9 9	15.0	BCL6, ITGAL, ITGB2, APOH, MBL2, LTF
26	dermatan sulfate32	11.9	VWF, SELP, SERPINC1, VCAN, BMP6, GTDC2
27	ketoconazole32 42 9 18 9	15.8	GSR, IL1A, CCND3, ALOX5, HMGCR, CYP1A1
28	phenylalanine32	11.7	SFTPC, SELPLG, BCR, AVP, INSR, CCR3
29	rofecoxib32 9 9	13.4	SELP, MT-CO2, MMP3, CCND1, CYP1A2, CYP2C9
30	bcnu32	11.0	PARP1, CDKN2A, MGMT, GSR, GSTP1, GSTT1
31	methotrexate32 34 42 9 9	INF	PCNA, SELE, SERPINE1, SERPINA3, NAT2, BRCA1
32	dbc-amp32	INF	PDE4A, BMP6, CHAT, CGA, CDKN1B, CD14
33	vincristine32 34 9 9	INF	BCL6, MGMT, FGF2, , PLA2G6, ABCB11
34	estrogen32	INF	LRP5, NCOA3, RERG, RETN, VWF, PCNA
35	citrate32	INF	SELP, VDR, MYO1A, MYOD1, SDHB, CHKB
36	flavopiridol32 9 9	INF	PIK3CG, VEGFA, PARP1, BCL2, BAK1, BAX
37	creatinine32	INF	REN, RETN, VWF, PCNA, GC, RBP4
38	vegf32	INF	PIK3CG, PDE4A, REN, RET, RETN, VWF
39	glyceraldehyde 3-phosphate32	INF	SETD2, MYOG, SDHB, MX1, MT-CO2, MMP1
40	gefitinib32 34 9 9	INF	PIK3CG, SFTPD, SELP, VEGFA, RAD51, CDKN1A
41	mitomycin c32	INF	VWF, PCNA, NBN, BRCA1, BRCA2, VCAM1
42	tacrolimus32 34 9 9	INF	PIN1, REN, PCNA, SERPINE1, VDR, MYC
43	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	INF	PCNA, MYC, PARP1, BCL2, BAK1, BAX
44	pge232	INF	PDE4A, REN, SFTPB, SELE, SETD2, VCAM1
45	nacl32	INF	REN, SFTPB, SERPINA3, VCAN, RAD51, LIPC
46	fluvastatin32 34 9 9	INF	VWF, SELP, SERPINE1, LPL, VCAM1, RAC1
47	erlotinib32 34 9 9	INF	VEGFA, CDKN1B, CDH1, , MAPK1, CCND1
48	anaphylatoxin32	INF	MPO, IL1B, IL3, IL4, IL6, IL8
49	morphine32 9 9	INF	UGT1A4, CDK5, IL1RN, IL5, CCR5, CCR3
50	suramin32 9 9	INF	PCNA, VEGFA, BMP6, LDLR, P2RX7, CFTR

Cellular components related to pulmonary disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PIK3CG, NCF2, PDE4A, RERG, PCTP, GC
2	extracellular region	GO:005576	INF	RETN, VWF, SFTPA1, SFTPD, GC, BTC
3	integral to plasma membrane	GO:005887	INF	RET, SELL, SELP, SELPLG, CLCA1, BDKRB2
4	cell surface	GO:009986	11.9	LRP6, VEGFA, LPL, VCAM1, SCARB1, CHRNA1
5	cytoplasm	GO:005737	INF	PIK3CG, PIN1, PIM1, NCF2, NCOA3, RERG
6	nucleoplasm	GO:005654	INF	PIN1, NCOA3, PCNA, NBN, BRCA1, BRCA2
7	extracellular space	GO:005615	INF	REN, SFTPA1, SFTPB, SFTPC, SFTPD, GC
8	external side of plasma membrane	GO:009897	INF	VWF, SELL, SELP, VCAM1, SCNN1G, LDLR
9	plasma membrane	GO:005886	INF	PIK3CG, PIM1, LRP5, LRP6, BTC, SELE

Biological processes related to pulmonary disease according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of apoptotic process	GO:043065	INF	LRP6, RARG, BCL6, BAK1, BARD1, BAX
2	cell-cell signaling	GO:007267	INF	NAMPT, CGA, AVP, CD86, CD80, ITGB2
3	cell proliferation	GO:008283	INF	PIM1, PCNA, NBN, CHRM1, CHRM3, BAK1
4	response to hypoxia	GO:001666	INF	SFTPB, SERPINA1, VEGFA, VCAM1, UTS2, BCL2
5	innate immune response	GO:045087	INF	PIK3CG, PIN1, NCF2, SFTPD, BCL2, CHUK
6	signal transduction	GO:007165	INF	PDE4A, RET, NAMPT, VDR, LITAF, BCR
7	immune response	GO:006955	17.1	BMP6, RAG1, CHIT1, CHUK, XBP1, CEBPB
8	chemotaxis	GO:006935	15.3	FGF2, IL4, MAPK14, MAPK1, CCR6, CCR2
9	negative regulation of apoptotic process	GO:043066	14.2	PIK3CG, PIM1, BTC, RB1CC1, SERPINE1, VEGFA
10	negative regulation of cell proliferation	GO:008285	13.9	RERG, SERPINE2, VDR, RARG, BECN1, BDKRB2
11	positive regulation of angiogenesis	GO:045766	13.5	SERPINE1, VEGFA, UTS2, CHI3L1, MMP9, FLT1
12	positive regulation of transcription, DNA-dependent	GO:045893	13.4	LRP5, LRP6, NCOA3, RET, SEC14L2, BRCA1
13	xenobiotic metabolic process	GO:006805	13.1	GCLM, NAT2, UGT1A4, MTR, GSTA4, GSTM1
14	anti-apoptosis	GO:006916	12.6	BIRC3, BECN1, BCL2, CEBPB, MPO, CD27
15	cytokine-mediated signaling pathway	GO:019221	12.6	PIN1, VCAM1, MX1, IRF1, IRF3, IL13RA2
16	regulation of blood pressure	GO:008217	12.5	LRP5, REN, UTS2, LEP, HMOX1, PTGS2
17	response to glucocorticoid stimulus	GO:051384	12.5	SFTPB, SFTPC, SERPINE1, BGLAP, UCP3, LCAT
18	DNA repair	GO:006281	12.5	PCNA, NBN, BRCA1, BRCA2, RAD51, RAD52
19	neutrophil chemotaxis	GO:030593	12.5	PIK3CG, ITGB2, IL1B, IL8, CCL2, CCL3
20	response to organic cyclic compound	GO:014070	12.5	NCF2, SELP, SERPINA1, BAK1, P2RX7, MSH2
21	lipopolysaccharide-mediated signaling pathway	GO:031663	12.4	SCARB1, LBP, IRF3, IL18, IL1B, MAPK14
22	defense response to Gram-negative bacterium	GO:050829	11.9	SELP, SERPINE1, LBP, CD4, IL12B, IL23A
23	cellular response to mechanical stimulus	GO:071260	11.9	SFTPB, SFTPC, CHEK1, BAK1, CD40, IRF1
24	response to ethanol	GO:045471	11.7	RBP4, BGLAP, BCL2, CHAT, BAK1, AVP
25	response to toxin	GO:009636	11.7	BCL2, BAX, CDKN1A, CDH1, MGMT, FAS
26	positive regulation of protein phosphorylation	GO:001934	11.7	PIN1, RB1CC1, VEGFA, AXIN2, CD40, INSR
27	positive regulation of inflammatory response	GO:050729	11.5	SERPINE1, IL12B, IL15, IL18, IL1RL1, IL2
28	induction of apoptosis by intracellular signals	GO:008629	11.2	MYC, BCL2, BAK1, BAX, MSH6, CDKN1A
29	positive regulation of smooth muscle cell proliferation	GO:048661	11.1	JUN, FLT1, IL13, IL6, IL6R, CCL5
30	induction of apoptosis	GO:006917	11.1	MX1, BAX, CEBPB, CD27, CDKN1B, CDKN2A
31	response to gamma radiation	GO:010332	11.0	BRCA2, MYC, BCL2, BAK1, BAX, XRCC4
32	response to DNA damage stimulus	GO:006974	10.9	BRCA1, MYC, BLM, PARP4, BCL2, BCL6
33	response to estradiol stimulus	GO:032355	10.8	GC, SERPINA1, BRCA2, VDR, AURKA, MMP9
34	phosphatidylinositol-mediated signaling	GO:048015	10.3	PCNA, CHUK, AURKA, CDKN1B, FOXO1, FOXO3
35	small molecule metabolic process	GO:044281	INF	PIK3CG, NCOA3, GC, GCLM, NAMPT, NAT2
36	cell surface receptor signaling pathway	GO:007166	INF	BIRC3, BDKRB2, LEPR, P2RX7, CD27, CD14
37	positive regulation of cell migration	GO:030335	INF	RET, VEGFA, CGA, MMP14, IRS1, FLT1
38	positive regulation of cell proliferation	GO:008284	INF	LRP5, BTC, NBN, NAMPT, VEGFA, MYC
39	virus-host interaction	GO:019048	INF	VCAM1, BECN1, SCARB1, LDLR, BAX, CD86
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	LRP5, LRP6, NCOA3, SERPINE1, BRCA1, VEGFA
41	response to lipopolysaccharide	GO:032496	INF	NCF2, SFTPB, SFTPC, SELE, SELP, SERPINA1
42	aging	GO:007568	INF	NCF2, VDR, VCAM1, UCP3, BAK1, JUN
43	positive regulation of MAP kinase activity	GO:043406	INF	PIK3CG, VEGFA, CD40, FLT1, FGFR1, HTR2A
44	response to drug	GO:042493	INF	NCF2, PDE4A, REN, GCLM, NBN, LPL
45	inflammatory response	GO:006954	INF	PIK3CG, SELE, SELP, SERPINA3, BMP6, RAC1
46	blood coagulation	GO:007596	INF	PIK3CG, VWF, SELL, SELP, SELPLG, SERPINE2
47	cellular response to lipopolysaccharide	GO:071222	INF	SERPINE1, LBP, CD14, GSTP1, IL10, IL12B
48	platelet activation	GO:030168	INF	PIK3CG, VWF, SELP, SERPINA1, SERPINE1, VEGFA
49	elevation of cytosolic calcium ion concentration	GO:007204	INF	UTS2, BDKRB2, AVP, IL1B, IL2, CCR6
50	G-protein coupled receptor signaling pathway	GO:007186	INF	PIK3CG, BDKRB2, CHRM2, CHRM1, CHRM3, INSR

Molecular functions related to pulmonary disease according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:020037	INF	CYP1A1, CYP1A2, CYP1B1, CYP3A7, CYP24A1, CYP2C19
2	cytokine activity	GO:005125	14.6	IL12B, FGF2, BMP6, VEGFA, NAMPT, ADIPOQ
3	growth factor activity	GO:008083	12.8	EGF, CTGF, F2, IGF1, IGF2, TGFB1
4	heparin binding	GO:008201	12.1	APOE, APOH, CCL2, CCL5, F11, CTGF
5	enzyme binding	GO:019899	11.7	CCND1, CBS, CAT, CAV1, AKT1, ESR1
6	protein heterodimerization activity	GO:046982	INF	GCLM, VEGFA, MYC, MYOG, MYF5, TP53
7	receptor binding	GO:005102	INF	NPPB, NPPA, CXCL16, CXCL10, CXCL1, CX3CL1
8	protein homodimerization activity	GO:042803	INF	CCL5, PDGFRA, SHBG, HIF1AN, TYR, TGFB1
9	protein binding	GO:005515	INF	STAT6, SLC2A4, SLPI, SLC6A3, SLC22A4, SLAMF1
10	electron carrier activity	GO:009055	INF	CYP3A7, CYP24A1, CYP2C19, GPX2, CYP2D6, CYP1B1