MCID: PLM129
MIFTS: 45

Pulmonary Disease, Chronic Obstructive malady

Respiratory diseases category
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Summaries for Pulmonary Disease, Chronic Obstructive

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4CDC, 65Wikipedia, 47OMIM, 33MalaCards
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CDC:4 Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.

MalaCards: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to respiratory failure and asthma. An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are Selected targets of C EBPbeta and Insulin receptor recycling. The compounds cacl2 and tc 14012 have been mentioned in the context of this disorder. Affiliated tissues include lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:65 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Description from OMIM:47 606963

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

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47OMIM, 31LifeMap Discovery™, 10DISEASES, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary disease, chronic obstructive 47 31
chronic obstructive pulmonary disease 10
pulmonary disease chronic obstructive 45


External Ids:

ICD1025 J44.0, J44.8

Related Diseases for Pulmonary Disease, Chronic Obstructive

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17GeneCards, 18GeneDecks
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Diseases in the Pulmonary Disease, Chronic Obstructive family:

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1respiratory failure31.2SERPINA1, SFTPB
2asthma31.1CLCA1, MUC2, MMP8, ADCYAP1, CXCR1, CCR3
3bronchiectasis31.1SERPINA1, MMP8
4lung cancer31.0ADCYAP1, MMP8, MUC2, SERPINA1, SFTPB
5pulmonary emphysema30.9SERPINA1, SERPINB1, MMP8, HMOX1
6periodontitis30.8MMP8, DEFB1
7bronchitis30.6SERPINA1
8cystic fibrosis30.6DEFB1, SFTPB, SERPINA1, CLCA1, MUC2, ADCYAP1
9interstitial lung disease30.4SFTPB, CCL11
10atopic dermatitis30.4CCL11, CCR3
11bronchiolitis obliterans30.3MMP8, HMOX1
12wegener's granulomatosis30.3SERPINA1, SERPINB1
13bronchiolitis30.3CCL11
14pneumonia30.3DEFB1, SFTPB, SERPINA1, SERPINB1, MMP8, CCL11
15arthritis30.3MMP8, ADCYAP1, CXCR1, CCR3, C5AR1
16stomach cancer30.2CXCR1, MUC2, SERPINA1
17tuberculosis30.2C5AR1, CXCR1, SERPINA1
18ischemia30.1ADCYAP1, CXCR1, C5AR1, HMOX1
19rheumatoid arthritis30.1SERPINA1, MMP8, ADCYAP1, CXCR1, CCR3, CCL11
20multiple sclerosis30.0CCL11, CCR3, CXCR1, ADCYAP1, MMP8
21atherosclerosis29.9MMP8, CXCR1, CCR3, CCL11, UCP3, C5AR1
22cor pulmonale10.8
23pulmonary function10.8
24hypertension10.7
25obstructive lung disease10.7
26aspergillosis10.7
27endotheliitis10.6
28idiopathic pulmonary fibrosis10.5
29pulmonary fibrosis10.5
30hypoxia10.5
31abdominal aortic aneurysm10.5
32aortic aneurysm10.5
33congestive heart failure10.5
34periodontal disease10.5
35aneurysm10.5
36osteoporosis10.4
37diffuse panbronchiolitis10.4
38blindness10.4
39panic disorder10.4
40gastroesophageal reflux disease10.4
41invasive aspergillosis10.4
42pulmonary edema10.4
43influenza10.4
44neuropathy10.4
45pneumoconiosis10.4
46pneumothorax10.4
47vascular disease10.4
48autonomic dysfunction10.4
49insomnia10.4
50insulin resistance10.4

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Symptoms for Pulmonary Disease, Chronic Obstructive

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47OMIM
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Clinical features from OMIM:

606963

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

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Anatomical Context for Pulmonary Disease, Chronic Obstructive

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

33
Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1HMOX1, CCL11, CCR3, SERPINB1, SFTPB
2MP:00053976.9SERPINB1, MUC2, ADCYAP1, CCR3, CCL11, C5AR1
3MP:00053766.8SFTPB, SERPINB1, MUC2, ADCYAP1, CCR3, UCP3
4MP:00053876.6HMOX1, DEFB1, SERPINB1, MUC2, MMP8, ADCYAP1

Publications for Pulmonary Disease, Chronic Obstructive

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Variations for Pulmonary Disease, Chronic Obstructive

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Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Disease, Chronic Obstructive

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Sources:
50PathCards, 12EMD Millipore, 55Reactome, 30KEGG, 54R&D Systems, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9UCP3, SERPINA1
2
Show member pathways
9.6HMOX1, MUC2, CXCR1
3
Show member pathways
9.2CCR3, CCL11, CXCR1
4
Show member pathways
9.2CCL11, CCR3, CXCR1
5
Show member pathways
9.2CCL11, CCR3, CXCR1
6
Show member pathways
Peptide GPCRs38
9.1CXCR1, CCR3, C5AR1
79.1CCL11, UCP3, C5AR1
8
Show member pathways
8.3CCL11, CCR3, CXCR1, ADCYAP1, C5AR1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cacl24510.0CXCR1, MMP8, SFTPB
2tc 14012619.9CCR3, CXCR1
3sb 22500261 2910.9CXCR1, CCR3
4sb 265610619.9CXCR1, CCR3
5rs 504393619.8CXCR1, CCR3
6peroxynitrite459.8CCL11, SERPINA1, SFTPB
7maraviroc45 61 51 29 1113.7CXCR1, CCR3
8salbutamol45 51 29 24 1113.6ADCYAP1, UCP3, CCL11
9tarc459.6CCR3, CCL11, CXCR1
10ccl345 2910.6CCL11, CXCR1, CCR3
11leukotriene b445 61 2411.5CXCR1, CCL11, C5AR1
12morphine45 51 29 1112.4CCR3, HMOX1, ADCYAP1
13ly294002459.4MUC2, UCP3, HMOX1, CCL11
14pranlukast45 29 1111.4CCL11, MUC2
15agarose459.4SERPINA1, MUC2, C5AR1
16fibrinogen459.4SERPINA1, MMP8, C5AR1, SFTPB
17pgd2459.4C5AR1, CCL11, CCR3
18cgmp45 2910.3CCL11, C5AR1, HMOX1, ADCYAP1
19progesterone45 29 61 24 1113.2ADCYAP1, MMP8, MUC2, SERPINA1, SFTPB
20fmlp459.2ADCYAP1, CCL11, C5AR1, CXCR1
21oligonucleotide459.1CXCR1, MMP8, C5AR1, MUC2, SERPINA1
22genistein45 29 61 3 24 1114.1CCL11, CXCR1, CCR3, MMP8
23phosphoinositide459.1CXCR1, CCL11, ADCYAP1, C5AR1
24cycloheximide459.1SFTPB, C5AR1, CXCR1, ADCYAP1, HMOX1
25wortmannin459.0C5AR1, ADCYAP1, CXCR1, CCR3
26gtp45 2910.0CXCR1, ADCYAP1, C5AR1, UCP3
27sb 20358045 619.9C5AR1, CCL11, HMOX1, ADCYAP1, MUC2
28glucose458.9ADCYAP1, DEFB1, SERPINA1, MUC2, UCP3, MMP8
29thymidine45 249.9SERPINA1, SFTPB, CCL11, CCR3, ADCYAP1
30nacl458.8DEFB1, SFTPB, CCR3, CCL11, C5AR1
31histamine45 29 2410.7ADCYAP1, HMOX1, CCL11, CCR3, C5AR1
32alanine458.7C5AR1, MMP8, CCL11, CCR3, HMOX1
33threonine458.7MUC2, C5AR1, ADCYAP1, SFTPB, CCL11
34pge2458.6HMOX1, C5AR1, CCL11, ADCYAP1, MMP8, SFTPB
35atp45 299.5C5AR1, UCP3, ADCYAP1, CLCA1, SFTPB
36rantes458.4CCL11, CXCR1, ADCYAP1, DEFB1, CCR3, C5AR1
37h2o2458.4SERPINA1, SERPINB1, HMOX1, C5AR1, ADCYAP1, MMP8
38actinomycin d458.4ADCYAP1, HMOX1, CCR3, CXCR1, SFTPB, MUC2
39cysteine458.1C5AR1, MMP8, CCR3, CXCR1, MUC2, SERPINA1
40dexamethasone45 51 29 1111.1ADCYAP1, CXCR1, CCR3, CCL11, SFTPB, DEFB1
41tyrosine458.1CXCR1, ADCYAP1, SERPINA1, CCR3, C5AR1, CCL11
42nitric oxide45 24 1110.0C5AR1, CCL11, HMOX1, SFTPB, ADCYAP1, SERPINA1
43vegf458.0MMP8, CXCR1, HMOX1, CCL11, C5AR1, ADCYAP1
44heparin45 29 24 1111.0C5AR1, CCL11, SERPINA1, SERPINB1, CCR3, UCP3
45superoxide45 248.9SERPINB1, HMOX1, MMP8, CXCR1, CCL11, UCP3
46serine457.9SFTPB, SERPINB1, MUC2, C5AR1, MMP8, ADCYAP1
47lipid457.9SERPINA1, C5AR1, UCP3, CCL11, CCR3, MMP8
48retinoic acid45 248.4HMOX1, UCP3, CCL11, CCR3, CXCR1, ADCYAP1
49oxygen45 248.2SFTPB, SERPINA1, HMOX1, MMP8, ADCYAP1, CXCR1
50calcium45 51 24 119.3SERPINB1, SFTPB, C5AR1, UCP3, CCL11, CCR3

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

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16Gene Ontology
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Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8CCL11, ADCYAP1, MMP8, SERPINA1, DEFB1
2extracellular spaceGO:0056157.1HMOX1, SFTPB, SERPINA1, SERPINB1, CLCA1, MMP8

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of muscle cell apoptotic processGO:01065610.0ADCYAP1, HMOX1
2positive regulation of vasodilationGO:0459099.8HMOX1, ADCYAP1
3chemokine-mediated signaling pathwayGO:0700989.6CXCR1, CCR3
4respiratory gaseous exchangeGO:0075859.5UCP3, SFTPB
5regulation of proteolysisGO:0301629.4SERPINB1, SERPINA1
6positive regulation of angiogenesisGO:0457669.4CCR3, CCL11, HMOX1
7positive regulation of cytosolic calcium ion concentrationGO:0072049.1C5AR1, CCR3, ADCYAP1
8inflammatory responseGO:0069548.8C5AR1, CCL11, CCR3, CXCR1
9chemotaxisGO:0069358.6C5AR1, CCL11, CCR3, CXCR1, DEFB1

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.7CCR3, CXCR1

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Disease, Chronic Obstructive

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet