MCID: PLM129
MIFTS: 53

Pulmonary Disease, Chronic Obstructive malady

Genetic diseases (common), Respiratory diseases categories

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
46OMIM, 30LifeMap Discovery®, 10DISEASES, 2CDC, 44Novoseek, 22GTR, 61UMLS, 25ICD10
See all sources

Aliases & Descriptions for Pulmonary Disease, Chronic Obstructive:

Name: Pulmonary Disease, Chronic Obstructive 46 30
Chronic Obstructive Pulmonary Disease 30 10 2
Pulmonary Disease Chronic Obstructive 44 22
 
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset 61
Copd, Rate of Decline of Lung Function in 46
Chronic Obstructive Airway Disease 61


Classifications:



External Ids:

OMIM46 606963
ICD1025 J44.0, J44.8

Summaries for Pulmonary Disease, Chronic Obstructive

About this section
OMIM:46 Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and... (606963) more...

MalaCards based summary: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to bronchitis and bronchiectasis, and has symptoms including chronic obstructive pulmonary disease An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Cell adhesion ECM remodeling. The compounds cacl2 and cxcl6 have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:64 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Related Diseases for Pulmonary Disease, Chronic Obstructive

About this section

Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis32.0SERPINA1
2bronchiectasis31.5SERPINA1, MMP8
3lung cancer31.1MUC2, MUC5AC, CXCR1, CXCR2
4periodontitis31.0DEFB1, MMP8, MMP1
5bronchiolitis obliterans31.0MMP8, HMOX1
6periodontal disease31.0DEFB1, MMP8, MMP1
7diverticulitis31.0SERPINA1
8bronchiolitis31.0CCL11
9pulmonary emphysema31.0SERPINA1, SERPINB1, MMP8, MMP1, HMOX1
10abdominal aortic aneurysm30.9MMP1, MMP8
11emphysema due to aat deficiency30.8SERPINA1, SERPINB1
12acute respiratory distress syndrome30.8SERPINA1, SFTPB
13interstitial lung disease30.6CCL11, SFTPB
14respiratory failure30.5SFTPB, MUC2, MUC5AC, CCR3, CCL11
15ischemia30.3ADCYAP1, CXCR1, C5AR1, HMOX1
16atopic dermatitis30.2CCL11, CCR3, CXCR1
17tuberculosis30.1SERPINA1, POMGNT2, CXCR1, CXCR2, C5AR1
18cystic fibrosis30.1DEFB1, SFTPB, SERPINA1, CLCA1, MUC2, MUC5AC
19allergic asthma29.9MUC5AC, CCR3, CCL11
20stomach cancer29.9SERPINA1, POMGNT2, MUC2, MUC5AC, CXCR1, CXCR2
21pneumonia29.9HMOX1, C5AR1, CCL11, CXCR2, MMP8, SERPINB1
22asthma29.5MUC5AC, MUC2, CLCA1, SERPINA1, SFTPB, DEFB1
23arthritis29.4MMP8, MMP1, ADCYAP1, CXCR1, CXCR2, CCR3
24atherosclerosis28.8MMP8, MMP1, CXCR1, CXCR2, CCR3, CCL11
25rheumatoid arthritis28.6SERPINA1, POMGNT2, MMP8, MMP1, ADCYAP1, CXCR1
26pulmonary function10.9
27cor pulmonale10.8
28obstructive lung disease10.8
29pulmonary hypertension10.7
30aspergillosis10.7
31endotheliitis10.7
32pulmonary fibrosis10.6
33congestive heart failure10.5
34aortic aneurysm10.5
35aneurysm10.5
36hypoxia10.5
37ampulla of vater carcinoma10.5MUC2
38biliary papillomatosis10.5MUC2
39influenza10.5
40osteoporosis10.4
41gastroesophageal reflux10.4
42obesity10.4
43neuropathy10.4
44vascular disease10.4
45blindness10.4
46oral submucous fibrosis10.4MMP1
47panic disorder10.4
48thrombocytosis10.4
49invasive aspergillosis10.4
50pulmonary edema10.4

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Symptoms for Pulmonary Disease, Chronic Obstructive

About this section


Clinical features from OMIM:

606963

HPO human phenotypes related to Pulmonary Disease, Chronic Obstructive:

id Description Frequency HPO Source Accession
1 chronic obstructive pulmonary disease HP:0006510

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

About this section

Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

About this section

Genetic tests related to Pulmonary Disease, Chronic Obstructive:

id Genetic test Affiliating Genes
1 Chronic Obstructive Pulmonary Disease22

Anatomical Context for Pulmonary Disease, Chronic Obstructive

About this section

MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

31
Kidney, Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

About this section

MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SERPINB1, CXCR2, CCR3, CCL11, HMOX1, SFTPB
2MP:00053977.1SERPINB1, MUC2, ADCYAP1, CXCR2, CCR3, CCL11
3MP:00053766.0MUC5AC, MUC2, SERPINB1, SFTPB, MMP1, ADCYAP1
4MP:00053875.9HMOX1, DEFB1, SERPINB1, MUC2, MUC5AC, MMP8

Publications for Pulmonary Disease, Chronic Obstructive

About this section

Variations for Pulmonary Disease, Chronic Obstructive

About this section

Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Disease, Chronic Obstructive patients vs. healthy controls: 30
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ARL11ADP-ribosylation factor-like 11Kidney+3.030.028
2TPK1thiamin pyrophosphokinase 1Kidney+3.020.002
3BCL2A1BCL2-related protein A1Kidney+3.020.022

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section

Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL11, MMP1
2
Show member pathways
Metalloproteases in connective tissue degradation
9.8MMP8, MMP1, CXCR1
3
Show member pathways
9.3MMP8, MMP1, CCR3, CCL11
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.2HMOX1, MUC5AC, MUC2
5
Show member pathways
9.2MUC2, CXCR1, CXCR2, HMOX1
6
Show member pathways
8.9CCL11, CCR3, CXCR2, CXCR1
7
Show member pathways
8.9CXCR1, CXCR2, CCR3, CCL11
8
Show member pathways
8.9CXCR1, CXCR2, CCR3, CCL11
9
Show member pathways
8.1ADCYAP1, CXCR1, CXCR2, CCR3, CCL11, C5AR1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section

Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cacl24410.0SFTPB, MMP8, CXCR1
2cxcl6289.9CXCR1, CXCR2
3cxcl1289.8CXCR1, CXCR2
4cxcl8289.8CXCR2, CXCR1
5[125i]cxcl8 (human)289.8CXCR2, CXCR1
6tc 14012609.6CXCR1, CCR3, CXCR2
7sb 265610609.6CXCR2, CCR3, CXCR1
8sb 22500260 2810.6CCR3, CXCR2, CXCR1
9rs 504393609.6CXCR2, CXCR1, CCR3
10maraviroc44 60 50 28 1113.6CCR3, CXCR2, CXCR1
11groalpha449.3CXCR2, CXCR1, CCL11
12salbutamol44 50 28 24 1113.2UCP3, CCL11, ADCYAP1
13cgmp44 2810.2HMOX1, ADCYAP1, CCL11, C5AR1
14herbimycin a44 6010.1CXCR2, CCL11, MMP1, CXCR1, CCR3
15nacl449.1DEFB1, C5AR1, CCL11, CCR3, SFTPB
16leukotriene b444 60 2411.0CXCR2, C5AR1, CCL11, CXCR1
17cycloheximide449.0SFTPB, MMP1, ADCYAP1, CXCR1, HMOX1, C5AR1
18ribonucleic acid448.9MUC5AC, SFTPB, MMP1, ADCYAP1, UCP3
19actinomycin d448.9CCL11, CCR3, HMOX1, CXCR1, ADCYAP1, MUC2
20fibrinogen448.9C5AR1, CXCR2, MMP8, SERPINA1, SFTPB
21genistein44 28 60 1 24 1113.8MMP8, CXCR1, CXCR2, MMP1, CCR3, CCL11
22fmlp448.8CXCR2, CXCR1, ADCYAP1, CCL11, C5AR1
23paraffin448.8MUC5AC, MUC2, SERPINA1, MMP1, SFTPB
24endotoxin448.7C5AR1, CXCR1, CCL11, CXCR2
25h2o2448.7SERPINA1, SERPINB1, MMP8, ADCYAP1, C5AR1, HMOX1
26wortmannin448.7C5AR1, CCR3, CXCR2, CXCR1, ADCYAP1
27prostaglandin448.6MUC5AC, ADCYAP1, C5AR1, MMP1, CCL11
28pd 98,059448.6C5AR1, ADCYAP1, MMP1, MUC2, MUC5AC
29phosphoinositide448.6ADCYAP1, C5AR1, CCL11, CXCR2, CXCR1
30progesterone44 28 60 24 1112.5MMP8, MUC2, MMP1, MUC5AC, SFTPB, SERPINA1
31glucose448.4DEFB1, MUC5AC, UCP3, ADCYAP1, MMP8, MUC2
32oligonucleotide448.4C5AR1, CXCR1, MMP1, MMP8, MUC2, MUC5AC
33histamine44 28 2410.3C5AR1, ADCYAP1, CCR3, HMOX1, MUC5AC, CCL11
34sb 20358044 609.2MUC2, MUC5AC, MMP1, ADCYAP1, CCL11, C5AR1
35rantes448.1CCR3, CXCR2, CXCR1, ADCYAP1, MMP1, C5AR1
36superoxide44 249.0CXCR2, CCL11, MMP8, C5AR1, UCP3, HMOX1
37pge2448.0SFTPB, HMOX1, C5AR1, CCL11, ADCYAP1, MMP8
38lipid447.7CXCR2, CXCR1, C5AR1, UCP3, SFTPB, CCL11
39threonine447.6C5AR1, SFTPB, MUC2, CCL11, CXCR2, MUC5AC
40dexamethasone44 50 28 1110.6CCL11, CCR3, CXCR1, ADCYAP1, MMP1, MUC5AC
41vegf447.6HMOX1, UCP3, CCL11, CXCR1, ADCYAP1, MMP1
42heparin44 28 24 1110.5SERPINB1, C5AR1, POMGNT2, CXCR2, CCR3, CCL11
43phosphatidylinositol447.5MUC5AC, CXCR2, C5AR1, ADCYAP1, CXCR1, CCL11
44tyrosine447.1SFTPB, CCL11, MUC5AC, C5AR1, SERPINA1, CXCR2
45nitric oxide44 24 119.0CXCR2, MMP8, MUC5AC, SFTPB, CCL11, C5AR1
46oxygen44 247.4SFTPB, ADCYAP1, MMP8, MUC5AC, SERPINA1, HMOX1
47serine446.4MUC5AC, SFTPB, SERPINA1, SERPINB1, C5AR1, CXCR2
48cysteine446.4HMOX1, MUC2, MUC5AC, MMP8, MMP1, CXCR1
49retinoic acid44 246.9DEFB1, POMGNT2, MUC2, MUC5AC, MMP1, ADCYAP1
50calcium44 50 24 118.7SFTPB, C5AR1, UCP3, CCL11, CCR3, CXCR2

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section

Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.9CCL11, ADCYAP1, MMP1, MMP8, SERPINA1, DEFB1
2Golgi lumenGO:00057968.9DEFB1, MUC2, MUC5AC
3extracellular spaceGO:00056158.1HMOX1, CCL11, ADCYAP1, MMP8, CLCA1, SERPINB1

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:004590910.0HMOX1, ADCYAP1
2negative regulation of muscle cell apoptotic processGO:00106569.9HMOX1, ADCYAP1
3interleukin-8-mediated signaling pathwayGO:00381129.7CXCR2, CXCR1
4chemokine-mediated signaling pathwayGO:00700989.4CCR3, CXCR2, CXCR1
5dendritic cell chemotaxisGO:00024079.3CXCR2, CXCR1
6positive regulation of angiogenesisGO:00457669.1CXCR2, CCR3, CCL11, HMOX1
7cellular defense responseGO:00069689.0CXCR2, CCR3, C5AR1
8positive regulation of cytosolic calcium ion concentrationGO:00072048.8C5AR1, CCR3, CXCR2, ADCYAP1
9inflammatory responseGO:00069548.5CXCR1, CXCR2, CCR3, CCL11, C5AR1
10chemotaxisGO:00069358.4C5AR1, CCL11, CCR3, CXCR2, CXCR1, DEFB1

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.9CCR3, CXCR1
2interleukin-8 receptor activityGO:00049189.5CXCR2, CXCR1
3interleukin-8 bindingGO:00199599.3CXCR2, CXCR1

Sources for Pulmonary Disease, Chronic Obstructive

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet