MCID: PLM129
MIFTS: 54

Pulmonary Disease, Chronic Obstructive malady

Genetic diseases (common), Respiratory diseases categories

Summaries for Pulmonary Disease, Chronic Obstructive

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OMIM:47 Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and... (606963) more...

MalaCards based summary: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to asthma and bronchitis, and has symptoms including chronic obstructive pulmonary disease An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Cell adhesion ECM remodeling. The compounds cacl2 and cxcl6 have been mentioned in the context of this disorder. Affiliated tissues include lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:65 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

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Sources:
47OMIM, 32LifeMap Discovery®, 12DISEASES, 4CDC, 45Novoseek, 24GTR, 27ICD10
See all sources

Pulmonary Disease, Chronic Obstructive, Aliases & Descriptions:

Name: Pulmonary Disease, Chronic Obstructive 47 32
Chronic Obstructive Pulmonary Disease 32 12 4
 
Pulmonary Disease Chronic Obstructive 45 24
Copd, Rate of Decline of Lung Function in 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


External Ids:

OMIM47 606963
ICD1027 J44.0, J44.8

Related Diseases for Pulmonary Disease, Chronic Obstructive

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Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.4CCR3, CXCR2, CXCR1, ADCYAP1, MMP8, MUC5AC
2bronchitis31.3SERPINA1
3lung cancer31.1MUC5AC, MUC2, CXCR1, CXCR2
4bronchiectasis31.1SERPINA1, MMP8
5respiratory failure31.0MUC5AC, CCL11, CCR3, MUC2, SFTPB
6pulmonary emphysema30.9HMOX1, MMP1, MMP8, SERPINB1, SERPINA1
7periodontitis30.8MMP8, MMP1, DEFB1
8periodontal disease30.8MMP8, DEFB1, MMP1
9abdominal aortic aneurysm30.8MMP1, MMP8
10cystic fibrosis30.7ADCYAP1, SFTPB, MUC5AC, MUC2, CLCA1, SERPINA1
11interstitial lung disease30.6CCL11, SFTPB
12pneumonia30.6CCL11, CXCR2, MMP8, SERPINB1, SERPINA1, SFTPB
13bronchiolitis obliterans30.5HMOX1, MMP8
14bronchiolitis30.5CCL11
15atopic dermatitis30.4CCL11, CCR3, CXCR1
16diverticulitis30.3SERPINA1
17arthritis30.3CXCR2, C5AR1, MMP1, CCR3, CXCR1, ADCYAP1
18emphysema due to aat deficiency30.3SERPINA1, SERPINB1
19acute respiratory distress syndrome30.3SFTPB, SERPINA1
20ischemia30.2C5AR1, HMOX1, CXCR1, ADCYAP1
21tuberculosis30.2SERPINA1, C5AR1, POMGNT2, CXCR1, CXCR2
22rheumatoid arthritis30.2C5AR1, CCL11, MMP8, MMP1, SERPINA1, ADCYAP1
23allergic asthma30.2CCR3, MUC5AC, CCL11
24stomach cancer30.2CXCR2, SERPINA1, POMGNT2, MUC5AC, CXCR1, MUC2
25atherosclerosis30.0CXCR1, MMP1, CXCR2, CCR3, CCL11, UCP3
26pulmonary function10.9
27cor pulmonale10.8
28obstructive lung disease10.8
29pulmonary hypertension10.7
30aspergillosis10.7
31endotheliitis10.7
32pulmonary fibrosis10.6
33congestive heart failure10.5
34aortic aneurysm10.5
35aneurysm10.5
36hypoxia10.5
37influenza10.5
38osteoporosis10.4
39gastroesophageal reflux10.4
40obesity10.4
41neuropathy10.4
42vascular disease10.4
43blindness10.4
44panic disorder10.4
45thrombocytosis10.4
46invasive aspergillosis10.4
47pulmonary edema10.4
48pneumoconiosis10.4
49pneumothorax10.4
50pulmonary embolism10.4

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Symptoms for Pulmonary Disease, Chronic Obstructive

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Clinical features from OMIM:

606963

HPO human phenotypes related to Pulmonary Disease, Chronic Obstructive:

id Description Frequency HPO Source Accession
1 chronic obstructive pulmonary disease HP:0006510

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

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Genetic tests related to Pulmonary Disease, Chronic Obstructive:

id Genetic test Affiliating Genes
1 Chronic Obstructive Pulmonary Disease24

Anatomical Context for Pulmonary Disease, Chronic Obstructive

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MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

33
Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SERPINB1, CXCR2, CCR3, CCL11, HMOX1, SFTPB
2MP:00053977.1SERPINB1, MUC2, ADCYAP1, CXCR2, CCR3, CCL11
3MP:00053766.0MUC5AC, MUC2, SERPINB1, SFTPB, MMP1, ADCYAP1
4MP:00053875.9HMOX1, DEFB1, SERPINB1, MUC2, MUC5AC, MMP8

Publications for Pulmonary Disease, Chronic Obstructive

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Variations for Pulmonary Disease, Chronic Obstructive

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Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

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LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Disease, Chronic Obstructive patients vs. healthy controls: 32 (show all 10)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ARL11ADP-ribosylation factor-like 11Kidney+3.030.028
2TPK1thiamin pyrophosphokinase 1Kidney+3.020.002
3BCL2A1BCL2-related protein A1Kidney+3.020.022
4LRP2BPLRP2 binding proteinKidney+2.990.013
5PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Kidney+2.980.033
6TEAD4TEA domain family member 4Kidney+2.980.001
7NAPSBnapsin B aspartic peptidase, pseudogeneKidney+2.970.020
8RFPL3SRFPL3 antisenseKidney+2.960.040
9METmet proto-oncogeneKidney+2.960.013
10LAMA3laminin, alpha 3Kidney+2.950.039


Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, CCL11
2
Show member pathways
9.8CXCR1, MMP8, MMP1
39.3CCL11, C5AR1, UCP3
4
Show member pathways
9.3CCL11, MMP8, MMP1, CCR3
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2HMOX1, MUC2, MUC5AC
6
Show member pathways
9.2MUC2, CXCR1, CXCR2, HMOX1
7
Show member pathways
8.9CCL11, CCR3, CXCR2, CXCR1
8
Show member pathways
8.9CXCR1, CCL11, CXCR2, CCR3
9
Show member pathways
8.9CXCR2, CCL11, CCR3, CXCR1
10
Show member pathways
Peptide GPCRs38
8.7CXCR2, CCR3, C5AR1, CXCR1
11
Show member pathways
8.1CXCR1, ADCYAP1, CXCR2, C5AR1, CCL11, CCR3

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cacl24510.0SFTPB, MMP8, CXCR1
2cxcl6309.9CXCR1, CXCR2
3cxcl1309.8CXCR1, CXCR2
4cxcl8309.8CXCR2, CXCR1
5[125i]cxcl8 (human)309.8CXCR2, CXCR1
6tc 14012619.6CXCR1, CCR3, CXCR2
7sb 265610619.6CXCR2, CCR3, CXCR1
8sb 22500261 3010.6CCR3, CXCR2, CXCR1
9rs 504393619.6CXCR2, CXCR1, CCR3
10maraviroc45 61 51 30 1313.6CCR3, CXCR2, CXCR1
11groalpha459.3CXCR2, CXCR1, CCL11
12salbutamol45 51 30 26 1313.2UCP3, CCL11, ADCYAP1
13cgmp45 3010.2HMOX1, ADCYAP1, CCL11, C5AR1
14herbimycin a45 6110.1CXCR2, CCL11, MMP1, CXCR1, CCR3
15nacl459.1DEFB1, C5AR1, CCL11, CCR3, SFTPB
16leukotriene b445 61 2611.0CXCR2, C5AR1, CCL11, CXCR1
17cycloheximide459.0SFTPB, MMP1, ADCYAP1, CXCR1, HMOX1, C5AR1
18ribonucleic acid458.9MUC5AC, SFTPB, MMP1, ADCYAP1, UCP3
19actinomycin d458.9CCL11, CCR3, HMOX1, CXCR1, ADCYAP1, MUC2
20fibrinogen458.9C5AR1, CXCR2, MMP8, SERPINA1, SFTPB
21genistein45 30 61 3 26 1313.8MMP8, CXCR1, CXCR2, MMP1, CCR3, CCL11
22fmlp458.8CXCR2, CXCR1, ADCYAP1, CCL11, C5AR1
23paraffin458.8MUC5AC, MUC2, SERPINA1, MMP1, SFTPB
24endotoxin458.7C5AR1, CXCR1, CCL11, CXCR2
25h2o2458.7SERPINA1, SERPINB1, MMP8, ADCYAP1, C5AR1, HMOX1
26wortmannin458.7C5AR1, CCR3, CXCR2, CXCR1, ADCYAP1
27prostaglandin458.6MUC5AC, ADCYAP1, C5AR1, MMP1, CCL11
28pd 98,059458.6C5AR1, ADCYAP1, MMP1, MUC2, MUC5AC
29phosphoinositide458.6ADCYAP1, C5AR1, CCL11, CXCR2, CXCR1
30progesterone45 30 61 26 1312.5MMP8, MUC2, MMP1, MUC5AC, SFTPB, SERPINA1
31glucose458.4DEFB1, MUC5AC, UCP3, ADCYAP1, MMP8, MUC2
32oligonucleotide458.4C5AR1, CXCR1, MMP1, MMP8, MUC2, MUC5AC
33histamine45 30 2610.3C5AR1, ADCYAP1, CCR3, HMOX1, MUC5AC, CCL11
34sb 20358045 619.2MUC2, MUC5AC, MMP1, ADCYAP1, CCL11, C5AR1
35rantes458.1CCR3, CXCR2, CXCR1, ADCYAP1, MMP1, C5AR1
36superoxide45 269.0CXCR2, CCL11, MMP8, C5AR1, UCP3, HMOX1
37pge2458.0SFTPB, HMOX1, C5AR1, CCL11, ADCYAP1, MMP8
38lipid457.7CXCR2, CXCR1, C5AR1, UCP3, SFTPB, CCL11
39threonine457.6C5AR1, SFTPB, MUC2, CCL11, CXCR2, MUC5AC
40dexamethasone45 51 30 1310.6CCL11, CCR3, CXCR1, ADCYAP1, MMP1, MUC5AC
41vegf457.6HMOX1, UCP3, CCL11, CXCR1, ADCYAP1, MMP1
42heparin45 30 26 1310.5SERPINB1, C5AR1, POMGNT2, CXCR2, CCR3, CCL11
43phosphatidylinositol457.5MUC5AC, CXCR2, C5AR1, ADCYAP1, CXCR1, CCL11
44tyrosine457.1SFTPB, CCL11, MUC5AC, C5AR1, SERPINA1, CXCR2
45nitric oxide45 26 139.0CXCR2, MMP8, MUC5AC, SFTPB, CCL11, C5AR1
46oxygen45 267.4SFTPB, ADCYAP1, MMP8, MUC5AC, SERPINA1, HMOX1
47serine456.4MUC5AC, SFTPB, SERPINA1, SERPINB1, C5AR1, CXCR2
48cysteine456.4HMOX1, MUC2, MUC5AC, MMP8, MMP1, CXCR1
49retinoic acid45 266.9DEFB1, POMGNT2, MUC2, MUC5AC, MMP1, ADCYAP1
50calcium45 51 26 138.7SFTPB, C5AR1, UCP3, CCL11, CCR3, CXCR2

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.9DEFB1, SERPINA1, MMP8, MMP1, ADCYAP1, CCL11
2Golgi lumenGO:00057968.9MUC5AC, MUC2, DEFB1
3extracellular spaceGO:00056158.1ADCYAP1, CLCA1, CCL11, HMOX1, SERPINB1, SERPINA1

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:004590910.0HMOX1, ADCYAP1
2negative regulation of muscle cell apoptotic processGO:00106569.9HMOX1, ADCYAP1
3interleukin-8-mediated signaling pathwayGO:00381129.7CXCR2, CXCR1
4chemokine-mediated signaling pathwayGO:00700989.4CCR3, CXCR2, CXCR1
5dendritic cell chemotaxisGO:00024079.3CXCR2, CXCR1
6positive regulation of angiogenesisGO:00457669.1CXCR2, CCR3, CCL11, HMOX1
7cellular defense responseGO:00069689.0CXCR2, CCR3, C5AR1
8positive regulation of cytosolic calcium ion concentrationGO:00072048.8C5AR1, CCR3, CXCR2, ADCYAP1
9inflammatory responseGO:00069548.5CXCR1, CXCR2, CCR3, CCL11, C5AR1
10chemotaxisGO:00069358.4C5AR1, CCL11, CCR3, CXCR2, CXCR1, DEFB1

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.9CCR3, CXCR1
2interleukin-8 receptor activityGO:00049189.5CXCR2, CXCR1
3interleukin-8 bindingGO:00199599.3CXCR2, CXCR1

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

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  • Antibodies
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  • Antibodies
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  • Kits and Assays

Sources for Pulmonary Disease, Chronic Obstructive

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet