MCID: PLM129
MIFTS: 51

Pulmonary Disease, Chronic Obstructive malady

Respiratory category

Summaries for Pulmonary Disease, Chronic Obstructive

Sources:
3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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CDC:3 Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.

MalaCards: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to asthma and vascular disease. An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways is Selected targets of C/EBPbeta. The compounds lipid and calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:64 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Description from OMIM:47 606963

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

Sources:
47OMIM, 10DISEASES, 45Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

pulmonary disease, chronic obstructive 47
chronic obstructive pulmonary disease 10
pulmonary disease chronic obstructive 45


External Ids:

ICD1025 J44.0, J44.8

Related Diseases for Pulmonary Disease, Chronic Obstructive

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pulmonary Disease, Chronic Obstructive family:

pulmonary disease, chronic obstructive, severe early-onset

Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1asthma36.6CCR4, CCR8, SFTPD, CTSG, AREG, CHRM1
2vascular disease36.0SOD3, AREG, AHSP, HMOX1
3bronchiectasis36.0SERPINA1, CTSG
4idiopathic pulmonary fibrosis35.9IL9, SFTPD, CCR4
5cystic fibrosis35.8CCL20, SFTPD, CTSG, PI3, IL9, HMOX1
6arthritis35.4CCL20, SOD3, CTSG, MMP12
7pulmonary sarcoidosis35.2IL9, SFTPD, CCR4
8allergic asthma35.2CCR4, SFTPD, IL9, ADAM33
9acute myocardial infarction35.2SERPINA1, AHSP, SOD3
10atherosclerosis35.2SOD3, PI3, GLRX, AHSP, MMP12, HMOX1
11tuberculosis35.2SERPINA1, CTSG, SFTPD, CCR4
12coronary heart disease35.2AHSP, SELPLG
13bronchitis31.1SERPINA1
14coronary artery disease,13.3SOD3, AHSP, MMP12, SELPLG
15primary hyperoxaluria13.3SOD3, CTSG, HMOX1, SERPINA1
16adult respiratory distress syndrome13.3SERPINA1, CTSG
17allergic rhinitis13.3CCR4, CCR8, IL9
18osteoarthritis13.3CCL20, CTSG, MMP12
19alzheimer's disease13.3HMOX1, GLRX, CHRM1, CTSG
20ulcerative colitis13.3CCL20, CTSG, PI3, TACR2, SERPINA1
21burkitt's lymphoma13.3CCR4, CCR8, IL9, HMOX1, SERPINA1
22cork-handlers' disease13.3SFTPD, SOD3, CTSG, PI3, AHSP, IL9
23human granulocytic anaplasmosis13.3MMP12, SELPLG
24adenocarcinoma13.3SFTPD, AREG, MMP12, HMOX1, SERPINA1
25cerebrovascular disease13.3SELPLG, SOD3
26congenital heart defect13.3GPR182, AHSP, CTSG, SOD3
27dementia13.3CHRM1
28dermatitis13.3CCR4
29encephalomyelitis13.3MMP12
30eosinophilia13.3CCR4, IL9
31extrinsic allergic alveolitis13.3SFTPD, PI3
32gastritis13.3SFTPD, AREG
33glioblastoma multiforme13.3MMP12, AREG
34inflammatory bowel disease13.3CCL20, CTSG, AREG, TACR2, SELPLG, SERPINA1
35interstitial lung disease13.3SFTPD
36ischemia13.3SELPLG, HMOX1, AHSP
37leukemia13.3CCL20, CTSG, AREG, IL9, HMOX1, SELPLG
38lung cancer13.3CCR4, SFTPD, AREG, IL9, MMP12, SERPINA1
39melanoma13.3CCR4, CCL20, AREG, MMP12, SERPINA1
40meningioma13.3MMP12
41multiple sclerosis13.3CCR4, CCR8, IL9, MMP12, SELPLG
42myocardial infarction13.3SELPLG, AHSP, SOD3
43pancreatic cancer13.3CCL20, AREG, GLRX, SERPINA1
44pneumonia13.3SFTPD, SOD3, CTSG, PI3, MMP12, HMOX1
45psoriasis13.3CCR4, CCL20, AREG, PI3, SERPINA1
46pulmonary emphysema13.3SFTPD, CTSG, MMP12, HMOX1, SERPINA1
47pulmonary fibrosis13.3CCR4, SFTPD, SOD3, HMOX1
48rheumatoid arthritis13.3CCR4, CCL20, SFTPD, SOD3, CTSG, AREG
49rhinitis13.3IL9
50sarcoidosis13.3CCR4, SFTPD, IL9

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Clinical Features for Pulmonary Disease, Chronic Obstructive

Sources:
47OMIM
See all sources

Clinical features from OMIM:

606963

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Genetic Tests for Pulmonary Disease, Chronic Obstructive

Anatomical Context for Pulmonary Disease, Chronic Obstructive

Sources:
33MalaCards
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MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

33
Brain, Heart, Smooth muscle, Skeletal muscle, Colon, Lung, Skin, Myeloid, Monocytes, T cells, B cells, Endothelial, Bronchial epithelium

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.5HMOX1
2MP:000538710.4HMOX1
3MP:000539710.2HMOX1

Publications for Pulmonary Disease, Chronic Obstructive

Sources:
51PubMed
See all sources

Articles related to Pulmonary Disease, Chronic Obstructive:

(show top 50)    (show all 1033)
idTitleAuthorsYear
1
Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial. (24363555)
2014
2
A pilot randomized study comparing two methods of non-invasive ventilation withdrawal after acute respiratory failure in chronic obstructive pulmonary disease. (23490403)
2013
3
Osteoporosis in chronic obstructive pulmonary disease. (23952337)
2013
4
Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease. (22272893)
2012
5
Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease. (23103736)
2012
6
Issues in pulmonary function testing for the screening and diagnosis of chronic obstructive pulmonary disease. (22262139)
2012
7
Predictors of pulmonary function response to treatment with salmeterol/fluticasone in patients with chronic obstructive pulmonary disease. (21394306)
2011
8
Relation of functional characteristics and serum alpha-1-antitrypsin (AAT) concentration in patients with PiMM phenotype and chronic obstructive pulmonary disease (COPD). (22075288)
2011
9
Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease. (20667157)
2010
10
The role of the phosphodiesterase-4 inhibitor, roflumilast, in chronic obstructive pulmonary disease. (20150838)
2010
11
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. (20020740)
2010
12
Autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD). (22263050)
2010
13
Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population. (20495862)
2010
14
Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-beta1 gene on chronic obstructive pulmonary disease susceptibility in Chinese. (20193474)
2010
15
Polymorphism of the genes for antioxidant defense enzymes and their association with the development of chronic obstructive pulmonary disease in the population of Bashkortostan]. (19705749)
2009
16
Benefits of alpine mountain climate of Bavaria in patients with allergic diseases and chronic obstructive pulmonary disease: results from the AURA* study. (19476022)
2009
17
Decreased sputum mature dendritic cells in healthy smokers and patients with chronic obstructive pulmonary disease. (19571571)
2009
18
Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. (19279160)
2009
19
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. (19604272)
2009
20
Serum surfactant protein D during acute exacerbations of chronic obstructive pulmonary disease. (20075511)
2009
21
Surgical management of secondary spontaneous pneumothorax in elderly patients with chronic obstructive pulmonary disease: retrospective study of 107 cases. (19707977)
2009
22
Expression of toll-like receptors on CD14+ monocytes from patients with chronic obstructive pulmonary disease and smokers]. (19080469)
2008
23
The Obstructive Lung Disease in Northern Sweden Chronic Obstructive Pulmonary Disease Study: design, the first year participation and mortality. (20298352)
2008
24
Physiological properties of human diaphragm muscle fibres and the effect of chronic obstructive pulmonary disease. (18372305)
2008
25
Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease. (18204156)
2007
26
Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. (17988548)
2007
27
Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease. (17907958)
2007
28
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology. (17090574)
2007
29
Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency. (17073633)
2006
30
Cilomilast: orally active selective phosphodiesterase-4 inhibitor for treatment of chronic obstructive pulmonary disease. (16985092)
2006
31
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. (16751413)
2006
32
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. (16456143)
2006
33
Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers. (15850494)
2005
34
Effect of yifei jianpi recipe on inflammatory cells, levels of interleukin-8 and tumor necrosis factor-alpha in sputum from patients with chronic obstructive pulmonary disease]. (15768871)
2005
35
The beta2-adrenergic receptor agonists in the treatment of chronic obstructive pulmonary disease]. (16463710)
2005
36
Global Initiative for Chronic Obstructive Lung Disease strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: an Asia-Pacific perspective. (15691232)
2005
37
The study of interleukin-13 gene promoter polymorphism in patients with chronic obstructive pulmonary disease]. (15388001)
2004
38
Common and uncommon features of rheumatoid arthritis and chronic obstructive pulmonary disease: clues to a future therapy. (15180449)
2004
39
Prospects for new drugs for chronic obstructive pulmonary disease. (15364192)
2004
40
Genetics of chronic obstructive pulmonary disease. (11199103)
2001
41
Chronic obstructive pulmonary disease: emerging therapies. (10959769)
2000
42
Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease. (10413721)
1999
43
Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. (10556172)
1999
44
The effect of gancao on glucocorticoid receptors in chronic obstructive pulmonary disease]. (11776547)
1999
45
Genetic risk factors for chronic obstructive pulmonary disease. (9192947)
1997
46
Predisposing conditions to bacterial infections in chronic obstructive pulmonary disease. (7767560)
1995
47
Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-controlled study. (1533606)
1992
48
Long-term oxygen therapy for cor pulmonale in patients with chronic obstructive pulmonary disease. (1925080)
1991
49
DNA polymorphisms of the alpha 1-antitrypsin gene region in patients with chronic obstructive pulmonary disease. (1969347)
1990
50
Hemodynamic effect of hydralazine in advanced, stable chronic obstructive pulmonary disease with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. (6692695)
1984

Genetic Variations for Pulmonary Disease, Chronic Obstructive

Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Disease, Chronic Obstructive

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

Sources:
12EMD Millipore
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Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SERPINA1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1lipid4510.9SERPINA1
2calcium45 50 11 2413.9
3histamine45 29 2412.9HMOX1
4nitric oxide45 11 2412.9SERPINA1, HMOX1
5serine4510.9
6cysteine4510.9HMOX1, SERPINA1
7superoxide45 2411.9HMOX1
8oxygen45 2411.9HMOX1, SERPINA1
9methacholine45 1111.9
10fibrinogen4510.9SERPINA1
11tyrosine4510.9SERPINA1
12tarc4510.9
13oligonucleotide4510.9SERPINA1
14dexamethasone45 50 29 1113.9HMOX1
15heparin45 29 11 2413.9SERPINA1
16alanine4510.9HMOX1
17ccl172910.9
18n acetylcysteine4510.9HMOX1
19polysaccharide4510.9SERPINA1
20tert-butylhydroperoxide4510.9HMOX1
21acetylcholine45 50 29 11 2414.9HMOX1
22endotoxin4510.9
23gamma-glutamylcysteine45 11 2412.9HMOX1
24nadph45 2411.8
25alpha lipoic acid4510.8SERPINA1, HMOX1
26arginine4510.8HMOX1
27iron45 2411.8HMOX1, SERPINA1
28phosphatidylinositol4510.8
29ccl345 2911.8
30thymidine45 2411.8SERPINA1
31ccl445 2911.8
32atropine45 29 1112.8
33rantes4510.8
34allergens4510.8
35peroxynitrite4510.8SERPINA1
36ascorbic acid45 2411.8SERPINA1, HMOX1
37indomethacin45 60 29 1113.8HMOX1
38tc 140126010.7
39sb 22500260 2911.7
40sb 2656106010.7
41rs 5043936010.7
42chlorate4510.7
43retinoic acid45 2411.6HMOX1
44isosorbide dinitrate45 50 1112.6HMOX1
45h2o24510.6HMOX1, SERPINA1
46maraviroc45 60 50 29 1114.5
47larc4510.5
48cholesterol45 29 11 2413.5SERPINA1
49sodium nitroprusside4510.4HMOX1
50kt 582345 2911.2HMOX1

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5SERPINA1, HMOX1

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.5
2immune responseGO:00695510.2

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.5
2C-C chemokine receptor activityGO:01649310.2

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Disease, Chronic Obstructive

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet