MCID: PLM129
MIFTS: 45

Pulmonary Disease, Chronic Obstructive malady

Respiratory diseases category

Summaries for Pulmonary Disease, Chronic Obstructive

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4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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CDC:4 Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.

MalaCards: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to respiratory failure and asthma. An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are Selected targets of C EBPbeta and Insulin receptor recycling. The compounds cacl2 and tc 14012 have been mentioned in the context of this disorder. Affiliated tissues include lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:66 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Description from OMIM:48 606963

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

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Sources:
48OMIM, 32LifeMap Discoveryā„¢, 11DISEASES, 46Novoseek, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary disease, chronic obstructive 48 32
chronic obstructive pulmonary disease 11
pulmonary disease chronic obstructive 46


External Ids:

ICD1026 J44.0, J44.8

Related Diseases for Pulmonary Disease, Chronic Obstructive

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Pulmonary Disease, Chronic Obstructive family:

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1respiratory failure31.2SERPINA1, SFTPB
2asthma31.1CLCA1, MUC2, MMP8, ADCYAP1, CXCR1, CCR3
3bronchiectasis31.1SERPINA1, MMP8
4lung cancer31.0ADCYAP1, MMP8, MUC2, SERPINA1, SFTPB
5pulmonary emphysema30.9SERPINA1, SERPINB1, MMP8, HMOX1
6periodontitis30.8MMP8, DEFB1
7bronchitis30.6SERPINA1
8cystic fibrosis30.6DEFB1, SFTPB, SERPINA1, CLCA1, MUC2, ADCYAP1
9interstitial lung disease30.4SFTPB, CCL11
10atopic dermatitis30.4CCL11, CCR3
11bronchiolitis obliterans30.3MMP8, HMOX1
12wegener's granulomatosis30.3SERPINA1, SERPINB1
13bronchiolitis30.3CCL11
14pneumonia30.3DEFB1, SFTPB, SERPINA1, SERPINB1, MMP8, CCL11
15arthritis30.3MMP8, ADCYAP1, CXCR1, CCR3, C5AR1
16stomach cancer30.2CXCR1, MUC2, SERPINA1
17tuberculosis30.2C5AR1, CXCR1, SERPINA1
18ischemia30.1ADCYAP1, CXCR1, C5AR1, HMOX1
19rheumatoid arthritis30.1SERPINA1, MMP8, ADCYAP1, CXCR1, CCR3, CCL11
20multiple sclerosis30.0CCL11, CCR3, CXCR1, ADCYAP1, MMP8
21atherosclerosis29.9MMP8, CXCR1, CCR3, CCL11, UCP3, C5AR1
22cor pulmonale10.8
23pulmonary function10.8
24hypertension10.7
25obstructive lung disease10.7
26aspergillosis10.7
27endotheliitis10.6
28idiopathic pulmonary fibrosis10.5
29pulmonary fibrosis10.5
30hypoxia10.5
31abdominal aortic aneurysm10.5
32aortic aneurysm10.5
33congestive heart failure10.5
34periodontal disease10.5
35aneurysm10.5
36osteoporosis10.4
37diffuse panbronchiolitis10.4
38blindness10.4
39panic disorder10.4
40gastroesophageal reflux disease10.4
41invasive aspergillosis10.4
42pulmonary edema10.4
43influenza10.4
44neuropathy10.4
45pneumoconiosis10.4
46pneumothorax10.4
47vascular disease10.4
48autonomic dysfunction10.4
49insomnia10.4
50insulin resistance10.4

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Symptoms for Pulmonary Disease, Chronic Obstructive

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48OMIM
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Clinical features from OMIM:

606963

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

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Anatomical Context for Pulmonary Disease, Chronic Obstructive

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34MalaCards
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MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

34
Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1HMOX1, CCL11, CCR3, SERPINB1, SFTPB
2MP:00053976.9SERPINB1, MUC2, ADCYAP1, CCR3, CCL11, C5AR1
3MP:00053766.8SFTPB, SERPINB1, MUC2, ADCYAP1, CCR3, UCP3
4MP:00053876.6HMOX1, DEFB1, SERPINB1, MUC2, MMP8, ADCYAP1

Publications for Pulmonary Disease, Chronic Obstructive

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Variations for Pulmonary Disease, Chronic Obstructive

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Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Disease, Chronic Obstructive

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Sources:
51PathCards, 13EMD Millipore, 56Reactome, 31KEGG, 55R&D Systems, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9UCP3, SERPINA1
2
Show member pathways
9.6HMOX1, MUC2, CXCR1
3
Show member pathways
9.2CCR3, CCL11, CXCR1
4
Show member pathways
9.2CCL11, CCR3, CXCR1
5
Show member pathways
9.2CCL11, CCR3, CXCR1
6
Show member pathways
Peptide GPCRs39
9.1CXCR1, CCR3, C5AR1
79.1CCL11, UCP3, C5AR1
8
Show member pathways
8.3CCL11, CCR3, CXCR1, ADCYAP1, C5AR1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cacl24610.0CXCR1, MMP8, SFTPB
2tc 14012629.9CCR3, CXCR1
3sb 22500262 3010.9CXCR1, CCR3
4sb 265610629.9CXCR1, CCR3
5rs 504393629.8CXCR1, CCR3
6peroxynitrite469.8CCL11, SERPINA1, SFTPB
7maraviroc46 62 52 30 1213.7CXCR1, CCR3
8salbutamol46 52 30 25 1213.6ADCYAP1, UCP3, CCL11
9tarc469.6CCR3, CCL11, CXCR1
10ccl346 3010.6CCL11, CXCR1, CCR3
11leukotriene b446 62 2511.5CXCR1, CCL11, C5AR1
12morphine46 52 30 1212.4CCR3, HMOX1, ADCYAP1
13ly294002469.4MUC2, UCP3, HMOX1, CCL11
14pranlukast46 30 1211.4CCL11, MUC2
15agarose469.4SERPINA1, MUC2, C5AR1
16fibrinogen469.4SERPINA1, MMP8, C5AR1, SFTPB
17pgd2469.4C5AR1, CCL11, CCR3
18cgmp46 3010.3CCL11, C5AR1, HMOX1, ADCYAP1
19progesterone46 30 62 25 1213.2ADCYAP1, MMP8, MUC2, SERPINA1, SFTPB
20fmlp469.2ADCYAP1, CCL11, C5AR1, CXCR1
21oligonucleotide469.1CXCR1, MMP8, C5AR1, MUC2, SERPINA1
22genistein46 30 62 3 25 1214.1CCL11, CXCR1, CCR3, MMP8
23phosphoinositide469.1CXCR1, CCL11, ADCYAP1, C5AR1
24cycloheximide469.1SFTPB, C5AR1, CXCR1, ADCYAP1, HMOX1
25wortmannin469.0C5AR1, ADCYAP1, CXCR1, CCR3
26gtp46 3010.0CXCR1, ADCYAP1, C5AR1, UCP3
27sb 20358046 629.9C5AR1, CCL11, HMOX1, ADCYAP1, MUC2
28glucose468.9ADCYAP1, DEFB1, SERPINA1, MUC2, UCP3, MMP8
29thymidine46 259.9SERPINA1, SFTPB, CCL11, CCR3, ADCYAP1
30nacl468.8DEFB1, SFTPB, CCR3, CCL11, C5AR1
31histamine46 30 2510.7ADCYAP1, HMOX1, CCL11, CCR3, C5AR1
32alanine468.7C5AR1, MMP8, CCL11, CCR3, HMOX1
33threonine468.7MUC2, C5AR1, ADCYAP1, SFTPB, CCL11
34pge2468.6HMOX1, C5AR1, CCL11, ADCYAP1, MMP8, SFTPB
35atp46 309.5C5AR1, UCP3, ADCYAP1, CLCA1, SFTPB
36rantes468.4CCL11, CXCR1, ADCYAP1, DEFB1, CCR3, C5AR1
37h2o2468.4SERPINA1, SERPINB1, HMOX1, C5AR1, ADCYAP1, MMP8
38actinomycin d468.4ADCYAP1, HMOX1, CCR3, CXCR1, SFTPB, MUC2
39cysteine468.1C5AR1, MMP8, CCR3, CXCR1, MUC2, SERPINA1
40dexamethasone46 52 30 1211.1ADCYAP1, CXCR1, CCR3, CCL11, SFTPB, DEFB1
41tyrosine468.1CXCR1, ADCYAP1, SERPINA1, CCR3, C5AR1, CCL11
42nitric oxide46 25 1210.0C5AR1, CCL11, HMOX1, SFTPB, ADCYAP1, SERPINA1
43vegf468.0MMP8, CXCR1, HMOX1, CCL11, C5AR1, ADCYAP1
44heparin46 30 25 1211.0C5AR1, CCL11, SERPINA1, SERPINB1, CCR3, UCP3
45superoxide46 258.9SERPINB1, HMOX1, MMP8, CXCR1, CCL11, UCP3
46serine467.9SFTPB, SERPINB1, MUC2, C5AR1, MMP8, ADCYAP1
47lipid467.9SERPINA1, C5AR1, UCP3, CCL11, CCR3, MMP8
48retinoic acid46 258.4HMOX1, UCP3, CCL11, CCR3, CXCR1, ADCYAP1
49oxygen46 258.2SFTPB, SERPINA1, HMOX1, MMP8, ADCYAP1, CXCR1
50calcium46 52 25 129.3SERPINB1, SFTPB, C5AR1, UCP3, CCL11, CCR3

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

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17Gene Ontology
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Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8CCL11, ADCYAP1, MMP8, SERPINA1, DEFB1
2extracellular spaceGO:0056157.1HMOX1, SFTPB, SERPINA1, SERPINB1, CLCA1, MMP8

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of muscle cell apoptotic processGO:01065610.0ADCYAP1, HMOX1
2positive regulation of vasodilationGO:0459099.8HMOX1, ADCYAP1
3chemokine-mediated signaling pathwayGO:0700989.6CXCR1, CCR3
4respiratory gaseous exchangeGO:0075859.5UCP3, SFTPB
5regulation of proteolysisGO:0301629.4SERPINB1, SERPINA1
6positive regulation of angiogenesisGO:0457669.4CCR3, CCL11, HMOX1
7positive regulation of cytosolic calcium ion concentrationGO:0072049.1C5AR1, CCR3, ADCYAP1
8inflammatory responseGO:0069548.8C5AR1, CCL11, CCR3, CXCR1
9chemotaxisGO:0069358.6C5AR1, CCL11, CCR3, CXCR1, DEFB1

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.7CCR3, CXCR1

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Disease, Chronic Obstructive

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet