MCID: PLM129
MIFTS: 53

Pulmonary Disease, Chronic Obstructive malady

Genetic diseases (common), Respiratory diseases categories

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

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Sources:
45OMIM, 30LifeMap Discovery®, 11DISEASES, 3CDC, 43Novoseek, 22GTR, 60UMLS, 25ICD10
See all sources

Pulmonary Disease, Chronic Obstructive, Aliases & Descriptions:

Name: Pulmonary Disease, Chronic Obstructive 45 30
Chronic Obstructive Pulmonary Disease 30 11 3
Pulmonary Disease Chronic Obstructive 43 22
 
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset 60
Copd, Rate of Decline of Lung Function in 45
Chronic Obstructive Airway Disease 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


External Ids:

OMIM45 606963
ICD1025 J44.0, J44.8

Summaries for Pulmonary Disease, Chronic Obstructive

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OMIM:45 Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and... (606963) more...

MalaCards based summary: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to bronchitis and bronchiectasis, and has symptoms including chronic obstructive pulmonary disease An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Cell adhesion ECM remodeling. The compounds cacl2 and cxcl6 have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:63 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Related Diseases for Pulmonary Disease, Chronic Obstructive

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Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis32.0SERPINA1
2bronchiectasis31.5SERPINA1, MMP8
3lung cancer31.1MUC2, MUC5AC, CXCR1, CXCR2
4periodontitis31.0DEFB1, MMP8, MMP1
5bronchiolitis obliterans31.0MMP8, HMOX1
6periodontal disease31.0DEFB1, MMP8, MMP1
7diverticulitis31.0SERPINA1
8bronchiolitis31.0CCL11
9pulmonary emphysema31.0SERPINA1, SERPINB1, MMP8, MMP1, HMOX1
10abdominal aortic aneurysm30.9MMP1, MMP8
11emphysema due to aat deficiency30.8SERPINA1, SERPINB1
12acute respiratory distress syndrome30.8SERPINA1, SFTPB
13interstitial lung disease30.6CCL11, SFTPB
14respiratory failure30.5SFTPB, MUC2, MUC5AC, CCR3, CCL11
15ischemia30.3ADCYAP1, CXCR1, C5AR1, HMOX1
16atopic dermatitis30.2CCL11, CCR3, CXCR1
17tuberculosis30.1SERPINA1, POMGNT2, CXCR1, CXCR2, C5AR1
18cystic fibrosis30.1DEFB1, SFTPB, SERPINA1, CLCA1, MUC2, MUC5AC
19allergic asthma29.9MUC5AC, CCR3, CCL11
20stomach cancer29.9SERPINA1, POMGNT2, MUC2, MUC5AC, CXCR1, CXCR2
21pneumonia29.9HMOX1, C5AR1, CCL11, CXCR2, MMP8, SERPINB1
22asthma29.5MUC5AC, MUC2, CLCA1, SERPINA1, SFTPB, DEFB1
23arthritis29.4MMP8, MMP1, ADCYAP1, CXCR1, CXCR2, CCR3
24atherosclerosis28.8MMP8, MMP1, CXCR1, CXCR2, CCR3, CCL11
25rheumatoid arthritis28.6SERPINA1, POMGNT2, MMP8, MMP1, ADCYAP1, CXCR1
26pulmonary function10.9
27cor pulmonale10.8
28obstructive lung disease10.8
29pulmonary hypertension10.7
30aspergillosis10.7
31endotheliitis10.7
32pulmonary fibrosis10.6
33congestive heart failure10.5
34aortic aneurysm10.5
35aneurysm10.5
36hypoxia10.5
37ampulla of vater carcinoma10.5MUC2
38biliary papillomatosis10.5MUC2
39influenza10.5
40osteoporosis10.4
41gastroesophageal reflux10.4
42obesity10.4
43neuropathy10.4
44vascular disease10.4
45blindness10.4
46oral submucous fibrosis10.4MMP1
47panic disorder10.4
48thrombocytosis10.4
49invasive aspergillosis10.4
50pulmonary edema10.4

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Symptoms for Pulmonary Disease, Chronic Obstructive

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Clinical features from OMIM:

606963

HPO human phenotypes related to Pulmonary Disease, Chronic Obstructive:

id Description Frequency HPO Source Accession
1 chronic obstructive pulmonary disease HP:0006510

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

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Genetic tests related to Pulmonary Disease, Chronic Obstructive:

id Genetic test Affiliating Genes
1 Chronic Obstructive Pulmonary Disease22

Anatomical Context for Pulmonary Disease, Chronic Obstructive

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MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

31
Kidney, Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SERPINB1, CXCR2, CCR3, CCL11, HMOX1, SFTPB
2MP:00053977.1SERPINB1, MUC2, ADCYAP1, CXCR2, CCR3, CCL11
3MP:00053766.0MUC5AC, MUC2, SERPINB1, SFTPB, MMP1, ADCYAP1
4MP:00053875.9HMOX1, DEFB1, SERPINB1, MUC2, MUC5AC, MMP8

Publications for Pulmonary Disease, Chronic Obstructive

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Variations for Pulmonary Disease, Chronic Obstructive

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Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

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LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Disease, Chronic Obstructive patients vs. healthy controls: 30
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ARL11ADP-ribosylation factor-like 11Kidney+3.030.028
2TPK1thiamin pyrophosphokinase 1Kidney+3.020.002
3BCL2A1BCL2-related protein A1Kidney+3.020.022

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL11, MMP1
2
Show member pathways
Metalloproteases in connective tissue degradation
9.8MMP8, MMP1, CXCR1
3
Show member pathways
9.3MMP8, MMP1, CCR3, CCL11
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.2HMOX1, MUC5AC, MUC2
5
Show member pathways
9.2MUC2, CXCR1, CXCR2, HMOX1
6
Show member pathways
8.9CCL11, CCR3, CXCR2, CXCR1
7
Show member pathways
8.9CXCR1, CXCR2, CCR3, CCL11
8
Show member pathways
8.9CXCR1, CXCR2, CCR3, CCL11
9
Show member pathways
8.1ADCYAP1, CXCR1, CXCR2, CCR3, CCL11, C5AR1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cacl24310.0SFTPB, MMP8, CXCR1
2cxcl6289.9CXCR1, CXCR2
3cxcl1289.8CXCR1, CXCR2
4cxcl8289.8CXCR2, CXCR1
5[125i]cxcl8 (human)289.8CXCR2, CXCR1
6tc 14012599.6CXCR1, CCR3, CXCR2
7sb 265610599.6CXCR2, CCR3, CXCR1
8sb 22500259 2810.6CCR3, CXCR2, CXCR1
9rs 504393599.6CXCR2, CXCR1, CCR3
10maraviroc43 59 49 28 1213.6CCR3, CXCR2, CXCR1
11groalpha439.3CXCR2, CXCR1, CCL11
12salbutamol43 49 28 24 1213.2UCP3, CCL11, ADCYAP1
13cgmp43 2810.2HMOX1, ADCYAP1, CCL11, C5AR1
14herbimycin a43 5910.1CXCR2, CCL11, MMP1, CXCR1, CCR3
15nacl439.1DEFB1, C5AR1, CCL11, CCR3, SFTPB
16leukotriene b443 59 2411.0CXCR2, C5AR1, CCL11, CXCR1
17cycloheximide439.0SFTPB, MMP1, ADCYAP1, CXCR1, HMOX1, C5AR1
18ribonucleic acid438.9MUC5AC, SFTPB, MMP1, ADCYAP1, UCP3
19actinomycin d438.9CCL11, CCR3, HMOX1, CXCR1, ADCYAP1, MUC2
20fibrinogen438.9C5AR1, CXCR2, MMP8, SERPINA1, SFTPB
21genistein43 28 59 2 24 1213.8MMP8, CXCR1, CXCR2, MMP1, CCR3, CCL11
22fmlp438.8CXCR2, CXCR1, ADCYAP1, CCL11, C5AR1
23paraffin438.8MUC5AC, MUC2, SERPINA1, MMP1, SFTPB
24endotoxin438.7C5AR1, CXCR1, CCL11, CXCR2
25h2o2438.7SERPINA1, SERPINB1, MMP8, ADCYAP1, C5AR1, HMOX1
26wortmannin438.7C5AR1, CCR3, CXCR2, CXCR1, ADCYAP1
27prostaglandin438.6MUC5AC, ADCYAP1, C5AR1, MMP1, CCL11
28pd 98,059438.6C5AR1, ADCYAP1, MMP1, MUC2, MUC5AC
29phosphoinositide438.6ADCYAP1, C5AR1, CCL11, CXCR2, CXCR1
30progesterone43 28 59 24 1212.5MMP8, MUC2, MMP1, MUC5AC, SFTPB, SERPINA1
31glucose438.4DEFB1, MUC5AC, UCP3, ADCYAP1, MMP8, MUC2
32oligonucleotide438.4C5AR1, CXCR1, MMP1, MMP8, MUC2, MUC5AC
33histamine43 28 2410.3C5AR1, ADCYAP1, CCR3, HMOX1, MUC5AC, CCL11
34sb 20358043 599.2MUC2, MUC5AC, MMP1, ADCYAP1, CCL11, C5AR1
35rantes438.1CCR3, CXCR2, CXCR1, ADCYAP1, MMP1, C5AR1
36superoxide43 249.0CXCR2, CCL11, MMP8, C5AR1, UCP3, HMOX1
37pge2438.0SFTPB, HMOX1, C5AR1, CCL11, ADCYAP1, MMP8
38lipid437.7CXCR2, CXCR1, C5AR1, UCP3, SFTPB, CCL11
39threonine437.6C5AR1, SFTPB, MUC2, CCL11, CXCR2, MUC5AC
40dexamethasone43 49 28 1210.6CCL11, CCR3, CXCR1, ADCYAP1, MMP1, MUC5AC
41vegf437.6HMOX1, UCP3, CCL11, CXCR1, ADCYAP1, MMP1
42heparin43 28 24 1210.5SERPINB1, C5AR1, POMGNT2, CXCR2, CCR3, CCL11
43phosphatidylinositol437.5MUC5AC, CXCR2, C5AR1, ADCYAP1, CXCR1, CCL11
44tyrosine437.1SFTPB, CCL11, MUC5AC, C5AR1, SERPINA1, CXCR2
45nitric oxide43 24 129.0CXCR2, MMP8, MUC5AC, SFTPB, CCL11, C5AR1
46oxygen43 247.4SFTPB, ADCYAP1, MMP8, MUC5AC, SERPINA1, HMOX1
47serine436.4MUC5AC, SFTPB, SERPINA1, SERPINB1, C5AR1, CXCR2
48cysteine436.4HMOX1, MUC2, MUC5AC, MMP8, MMP1, CXCR1
49retinoic acid43 246.9DEFB1, POMGNT2, MUC2, MUC5AC, MMP1, ADCYAP1
50calcium43 49 24 128.7SFTPB, C5AR1, UCP3, CCL11, CCR3, CXCR2

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

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Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.9DEFB1, SERPINA1, MMP8, MMP1, ADCYAP1, CCL11
2Golgi lumenGO:00057968.9MUC5AC, MUC2, DEFB1
3extracellular spaceGO:00056158.1ADCYAP1, CLCA1, CCL11, HMOX1, SERPINB1, SERPINA1

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:004590910.0HMOX1, ADCYAP1
2negative regulation of muscle cell apoptotic processGO:00106569.9HMOX1, ADCYAP1
3interleukin-8-mediated signaling pathwayGO:00381129.7CXCR2, CXCR1
4chemokine-mediated signaling pathwayGO:00700989.4CCR3, CXCR2, CXCR1
5dendritic cell chemotaxisGO:00024079.3CXCR2, CXCR1
6positive regulation of angiogenesisGO:00457669.1CXCR2, CCR3, CCL11, HMOX1
7cellular defense responseGO:00069689.0CXCR2, CCR3, C5AR1
8positive regulation of cytosolic calcium ion concentrationGO:00072048.8C5AR1, CCR3, CXCR2, ADCYAP1
9inflammatory responseGO:00069548.5CXCR1, CXCR2, CCR3, CCL11, C5AR1
10chemotaxisGO:00069358.4C5AR1, CCL11, CCR3, CXCR2, CXCR1, DEFB1

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.9CCR3, CXCR1
2interleukin-8 receptor activityGO:00049189.5CXCR2, CXCR1
3interleukin-8 bindingGO:00199599.3CXCR2, CXCR1

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pulmonary Disease, Chronic Obstructive

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet