MCID: PLM129
MIFTS: 45

Pulmonary Disease, Chronic Obstructive malady

Respiratory diseases category

Summaries for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
3CDC, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.

MalaCards: Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to asthma and lung cancer. An important gene associated with Pulmonary Disease, Chronic Obstructive is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways is Selected targets of C/EBPbeta. The compounds lipid and calcium have been mentioned in the context of this disorder. Affiliated tissues include lung and bone, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:63 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

Description from OMIM:46 606963

Aliases & Classifications for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary disease, chronic obstructive 46 30
chronic obstructive pulmonary disease 10
pulmonary disease chronic obstructive 44


External Ids:

ICD1025 J44.0, J44.8

Related Diseases for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pulmonary Disease, Chronic Obstructive family:

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Diseases related to Pulmonary Disease, Chronic Obstructive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1asthma36.5CCR4, CCR8, SFTPD, CTSG, AREG, CHRM1
2lung cancer36.0CCR4, SFTPD, AREG, IL9, MMP12, SERPINA1
3pulmonary emphysema36.0SFTPD, CTSG, MMP12, HMOX1, SERPINA1
4pulmonary fibrosis36.0CCR4, SFTPD, SOD3, HMOX1
5vascular disease35.9SOD3, AREG, AHSP, HMOX1
6bronchiectasis35.9SERPINA1, CTSG
7idiopathic pulmonary fibrosis35.8IL9, SFTPD, CCR4
8cystic fibrosis35.7CCL20, SFTPD, CTSG, PI3, IL9, HMOX1
9pneumonia35.5SFTPD, SOD3, CTSG, PI3, MMP12, HMOX1
10arthritis35.3CCL20, SOD3, CTSG, MMP12
11dermatitis35.3CCR4
12interstitial lung disease35.3SFTPD
13rheumatoid arthritis35.3CCR4, CCL20, SFTPD, SOD3, CTSG, AREG
14pulmonary sarcoidosis35.1IL9, SFTPD, CCR4
15allergic asthma35.1CCR4, SFTPD, IL9, ADAM33
16acute myocardial infarction35.1SERPINA1, AHSP, SOD3
17atherosclerosis35.1SOD3, PI3, GLRX, AHSP, MMP12, HMOX1
18ischemia35.1SELPLG, HMOX1, AHSP
19multiple sclerosis35.1CCR4, CCR8, IL9, MMP12, SELPLG
20myocardial infarction35.1SELPLG, AHSP, SOD3
21rhinitis35.1IL9
22sarcoidosis35.1CCR4, SFTPD, IL9
23tuberculosis35.1SERPINA1, CTSG, SFTPD, CCR4
24bronchitis30.4SERPINA1
25coronary artery disease13.3SOD3, AHSP, MMP12, SELPLG
26primary hyperoxaluria13.3SOD3, CTSG, HMOX1, SERPINA1
27adult respiratory distress syndrome13.3SERPINA1, CTSG
28allergic rhinitis13.3CCR4, CCR8, IL9
29osteoarthritis13.3CCL20, CTSG, MMP12
30alzheimer's disease13.3HMOX1, GLRX, CHRM1, CTSG
31ulcerative colitis13.3CCL20, CTSG, PI3, TACR2, SERPINA1
32burkitt's lymphoma13.3CCR4, CCR8, IL9, HMOX1, SERPINA1
33cork-handlers' disease13.3SFTPD, SOD3, CTSG, PI3, AHSP, IL9
34human granulocytic anaplasmosis13.3MMP12, SELPLG
35adenocarcinoma13.3SFTPD, AREG, MMP12, HMOX1, SERPINA1
36cerebrovascular disease13.3SELPLG, SOD3
37congenital heart defect13.3GPR182, AHSP, CTSG, SOD3
38dementia13.3CHRM1
39encephalomyelitis13.3MMP12
40eosinophilia13.3CCR4, IL9
41extrinsic allergic alveolitis13.3SFTPD, PI3
42gastritis13.3SFTPD, AREG
43glioblastoma multiforme13.3MMP12, AREG
44inflammatory bowel disease13.3CCL20, CTSG, AREG, TACR2, SELPLG, SERPINA1
45leukemia13.3CCL20, CTSG, AREG, IL9, HMOX1, SELPLG
46melanoma13.3CCR4, CCL20, AREG, MMP12, SERPINA1
47meningioma13.3MMP12
48pancreatic cancer13.3CCL20, AREG, GLRX, SERPINA1
49psoriasis13.3CCR4, CCL20, AREG, PI3, SERPINA1
50systemic scleroderma13.3MMP12, CTSG, SFTPD

Graphical network of the top 20 diseases related to Pulmonary Disease, Chronic Obstructive:



Diseases related to pulmonary disease, chronic obstructive

Clinical Features for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

606963

Drugs & Therapeutics for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Drug clinical trials:

Search ClinicalTrials for Pulmonary Disease, Chronic Obstructive

Search NIH Clinical Center for Pulmonary Disease, Chronic Obstructive

Search CenterWatch for Pulmonary Disease, Chronic Obstructive

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells for chronic obstructive pulmonary disease
Prochymal
StempeucelCOPD
Embryonic/Adult Cultured Cells Related to Pulmonary Disease, Chronic Obstructive:
Bone marrow-derived mononuclear cells, PMIDs: 21653527, 23054962, 21311694
Bone marrow-derived mesenchymal stem cells, PMIDs: 23172272, 21653527
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Pulmonary Disease, Chronic Obstructive

About this section

Anatomical Context for Pulmonary Disease, Chronic Obstructive

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Disease, Chronic Obstructive:

32
Lung, Bone

Animal Models for Pulmonary Disease, Chronic Obstructive or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Disease, Chronic Obstructive:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.5HMOX1
2MP:000538710.4HMOX1
3MP:000539710.2HMOX1

Publications for Pulmonary Disease, Chronic Obstructive

About this section

Genetic Variations for Pulmonary Disease, Chronic Obstructive

About this section

Expression for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Disease, Chronic Obstructive

Search GEO for disease gene expression data for Pulmonary Disease, Chronic Obstructive.

Pathways for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
Sources:
12EMD Millipore
See all sources

Pathways related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SERPINA1

Compounds for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1lipid4410.9SERPINA1
2calcium44 49 11 2413.9
3histamine44 28 2412.9HMOX1
4nitric oxide44 11 2412.9SERPINA1, HMOX1
5serine4410.9
6cysteine4410.9HMOX1, SERPINA1
7superoxide44 2411.9HMOX1
8oxygen44 2411.9HMOX1, SERPINA1
9methacholine44 1111.9
10fibrinogen4410.9SERPINA1
11tyrosine4410.9SERPINA1
12tarc4410.9
13oligonucleotide4410.9SERPINA1
14dexamethasone44 49 28 1113.9HMOX1
15heparin44 28 11 2413.9SERPINA1
16alanine4410.9HMOX1
17ccl172810.9
18n acetylcysteine4410.9HMOX1
19polysaccharide4410.9SERPINA1
20tert-butylhydroperoxide4410.9HMOX1
21acetylcholine44 49 28 11 2414.9HMOX1
22endotoxin4410.9
23gamma-glutamylcysteine44 11 2412.9HMOX1
24nadph44 2411.8
25alpha lipoic acid4410.8SERPINA1, HMOX1
26arginine4410.8HMOX1
27iron44 2411.8HMOX1, SERPINA1
28phosphatidylinositol4410.8
29ccl344 2811.8
30thymidine44 2411.8SERPINA1
31ccl444 2811.8
32atropine44 28 1112.8
33rantes4410.8
34allergens4410.8
35peroxynitrite4410.8SERPINA1
36ascorbic acid44 2411.8SERPINA1, HMOX1
37indomethacin44 59 28 1113.8HMOX1
38tc 140125910.7
39sb 22500259 2811.7
40sb 2656105910.7
41rs 5043935910.7
42chlorate4410.7
43retinoic acid44 2411.6HMOX1
44isosorbide dinitrate44 49 1112.6HMOX1
45h2o24410.6HMOX1, SERPINA1
46maraviroc44 59 49 28 1114.5
47larc4410.5
48cholesterol44 28 11 2413.5SERPINA1
49sodium nitroprusside4410.4HMOX1
50hocl4410.2SERPINA1

GO Terms for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.5SERPINA1, HMOX1

Biological processes related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.5
2immune responseGO:00695510.2

Molecular functions related to Pulmonary Disease, Chronic Obstructive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.5
2C-C chemokine receptor activityGO:01649310.2

Products for genes affiliated with Pulmonary Disease, Chronic Obstructive

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Disease, Chronic Obstructive

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet