MCID: PLM010
MIFTS: 50

Pulmonary Edema malady

Summaries for Pulmonary Edema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pulmonary edema (American English), or oedema (British English; both words from the Greek... more...

MalaCards: Pulmonary Edema is related to hypertension and myocardial infarction. An important gene associated with Pulmonary Edema is NPPB (natriuretic peptide B), and among its related pathways are Signal regulatory protein (SIRP) family interactions and FOXA1 transcription factor network. The drugs bumetanide and ethacrynate sodium and the compounds pge2 and thallium have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Pulmonary Edema

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

pulmonary edema 8 60


External Ids:

Disease Ontology8 DOID:11396
NCIt39 C26868
MeSH34 D011654

Related Diseases for Pulmonary Edema

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.8CYBA, CYP11B2, PPBP, NPPB
2myocardial infarction30.5NPPB, PPBP, PIK3C2A, CYP11B2, CYBA
3acute myocardial infarction30.5PIK3C2A, PPBP, NPPB
4adult respiratory distress syndrome30.5PPBP, ELANE
5pneumonia30.3SCGB1A1, PIK3C2A, SMPD1, ELANE
6congestive heart failure30.2CYP11B2, PIK3C2A, PPBP, NPPB
7sarcoidosis30.1SCGB1A1
8respiratory failure30.1CSAD, SCGB1A1, PIK3C2A
9disseminated intravascular coagulation30.1PPBP, PIK3C2A, OXT, ELANE
10ischemia30.1NPPB, PIK3C2A
11bronchiolitis obliterans29.9SCGB1A1
12coronary artery disease29.9NPPB, PPBP, PIK3C2A, CYBA, CLEC4A
13neuroleptic malignant syndrome29.9PIK3C2A
14pneumothorax10.5
15brain edema10.4
16epiglottitis10.3
17pulmonary embolism10.3
18rheumatic fever10.2
19toxic pneumonitis10.2
20pulmonary edema of mountaineers10.2
21cerebritis10.2
22croup10.2
23ovarian hyperstimulation syndrome10.2
24hypercalcemia10.2
25adult syndrome10.2
26bronchopneumonia10.2
27mediastinitis10.2
28hellp syndrome10.1
29primary pulmonary hypertension10.1
30cardiac tamponade10.1
31anuria10.1
32status epilepticus10.1
33pulmonary sarcoidosis10.1
34intracranial aneurysm10.1
35hypoglycemia10.1
36peripartum cardiomyopathy10.1
37hantavirus pulmonary syndrome10.1
38acute myocarditis10.1
39asthma10.1
40diabetes mellitus10.1
41encephalitis10.1
42hyperparathyroidism10.1
43malaria10.1
44meningitis10.1
45multiple sclerosis10.1
46myocarditis10.1
47acute mountain sickness10.1
48hypercholesterolemia10.0PPBP, CYBA
49stroke, ischemic10.0PPBP
50rhinitis10.0SCGB1A1

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to pulmonary edema

Clinical Features for Pulmonary Edema

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Drugs & Therapeutics for Pulmonary Edema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Edema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Edema

Search NIH Clinical Center for Pulmonary Edema

Search CenterWatch for Pulmonary Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Edema:

32
Lung, Heart, Endothelial, Brain, Kidney, Spinal cord, Liver, Bronchial epithelium, Lymph node

Animal Models for Pulmonary Edema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9ELANE, SCGB1A1, PIK3C2A, OXT, CYP11B2, CYBA

Publications for Pulmonary Edema

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50PubMed
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Articles related to Pulmonary Edema:

(show top 50)    (show all 643)
idTitleAuthorsYear
1
Atrial natriuretic peptide attenuates agonist-induced pulmonary edema in mice with targeted disruption of the gene for natriuretic peptide receptor-A. (23195629)
2013
2
Coexistence of dynamic mitral regurgitation and dynamic left ventricular dyssynchrony in a patient with repeated episodes of acute pulmonary edema: Improvement with cardiac resynchronization therapy. (24287018)
2013
3
Down-regulated expression of AQP5 on lung in rat DIC model induced by LPS and its effect on the development of pulmonary edema. (23538169)
2013
4
Flash pulmonary edema and the diagnostic suspicion of Pickering syndrome. (23324910)
2013
5
Reexpansion pulmonary edema following thoracentesis. (24015397)
2013
6
Cardiac biomarkers and high altitude pulmonary edema. (23632120)
2013
7
Pulmonary edema complicating ritodrine infusion in a patient with premature labor. (23291694)
2013
8
A pig model for blunt chest trauma: no pulmonary edema in the early phase. (23809093)
2013
9
Nonketotic hyperglycinemia presenting as pulmonary hypertensive vascular disease and fatal pulmonary edema in response to pulmonary vasodilator therapy. (22658788)
2012
10
Stress-induced cardiomyopathy after negative pressure pulmonary edema during emergence from anesthesia -A case report-. (22323959)
2012
11
Surfactant protein A (SP-A) and angiotensin converting enzyme (ACE) as early biomarkers for pulmonary edema formation in ventilated human lung lobes. (22466057)
2012
12
Arteriovenous fistula after femoral artery puncture leading to pulmonary edema: the role of ultrasonography. (22373805)
2012
13
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. (22324977)
2012
14
Causes and correlates of anemia in 200 patients with acute cardiogenic pulmonary edema. (22818627)
2012
15
The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome. (23232188)
2012
16
The role of inflammatory mediators in the association of pulmonary edema with increased cardiac index and pulmonary vascular filling. (23080456)
2012
17
Bosentan effects in hypoxic pulmonary vasoconstriction: Preliminary study in subjects with or without high altitude pulmonary edema-history. (22558517)
2012
18
Negative pressure pulmonary edema: consider undiagnosed obstructive sleep apnea too. (22553275)
2012
19
"Pulmonary edema induced by scorpion venom: evidence of cardiogenic nature". (22609008)
2012
20
Neurogenic pulmonary edema following intracranial coil embolization for subarachnoid hemorrhage -A case report-. (23115693)
2012
21
Is the noninvasive ventilatory mode of importance during cardiogenic pulmonary edema? (21136038)
2011
22
Pulmonary edema during cesarean delivery in a patient with a mediastinal mass. (21132475)
2011
23
Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema. (21755356)
2011
24
The use of the Boussignac CPAP device during cardiogenic pulmonary edema (CPE): why add air to the oxygen gas source? (21691887)
2011
25
Unilateral pulmonary edema after laparoscopic nephrectomy. (22096298)
2011
26
Acute postoperative negative-pressure pulmonary edema. (21266868)
2011
27
Neurogenic pulmonary edema after rupture of intracranial aneurysm during endovascular coiling. (21957417)
2011
28
Endothelial nitric oxide synthase gene polymorphisms associated with susceptibility to high altitude pulmonary edema in Chinese railway construction workers at Qinghai-Tibet over 4 500 meters above sea level. (21232181)
2010
29
Subarachnoid hemorrhage and hydrocephalus causing neurogenic pulmonary edema. (20602055)
2010
30
Pulmonary edema after da Vinci-assisted laparoscopic radical prostatectomy: a case report. (20650386)
2010
31
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice. (20938335)
2010
32
Negative pressure post-extubation pulmonary edema after laparoscopic appendectomy. (21683014)
2010
33
Pulmonary edema and blood volume after aneurysmal subarachnoid hemorrhage: a prospective observational study. (20331893)
2010
34
The exercise-induced pulmonary edema story doesna89t hold water. (20960685)
2010
35
Negative pressure pulmonary edema complicating an electrophysiological study. (19446350)
2009
36
Tako-tsubo cardiomyopathy presenting with acute pulmonary edema. (19187409)
2009
37
Noninvasive positive pressure ventilation: effect on mortality in acute cardiogenic pulmonary edema: a pragmatic meta-analysis. (19694215)
2009
38
Is helmet CPAP first line pre-hospital treatment of presumed severe acute pulmonary edema? (19030843)
2009
39
Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice. (19875734)
2009
40
Reexpansion pulmonary edema. (18818568)
2008
41
De novo multiple endocrine neoplasia type 2B with noncardiogenic pulmonary edema as the presenting symptom. (16829704)
2006
42
Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema. (15635619)
2005
43
Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. (11208643)
2001
44
Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. (9700111)
1998
45
Acute pulmonary edema caused by accidental aspiration of sweetened water in two cases of diabetes mellitus. (9868963)
1998
46
Surgical management of flash pulmonary edema secondary to renovascular hypertension. (9293835)
1997
47
High-altitude pulmonary edema in Japan]. (8752474)
1995
48
Neurogenic pulmonary edema associated with pneumococcal meningitis. (7586913)
1995
49
Unilateral pulmonary edema related to pulmonary artery compression resulting from acute dissecting aortic aneurysm. (8237774)
1993
50
Blood rheology in acute mountain sickness and high-altitude pulmonary edema. (1757331)
1991

Genetic Variations for Pulmonary Edema

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Expression for genes affiliated with Pulmonary Edema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for genes affiliated with Pulmonary Edema

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Pulmonary Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SFTPA2, SFTPA1
210.3SCGB1A1, SFTPA2, SFTPA1
3
Hide members
10.3CLDN18, SFTPA2, SFTPA1

Compounds for genes affiliated with Pulmonary Edema

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Pulmonary Edema according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1pge24410.8SMPD1
2thallium4410.7NPPB, PIK3C2A
3ptca4410.7NPPB, PPBP, PIK3C2A
4nitrate4410.7PIK3C2A, PPBP, NPPB
5nitroglycerin44 1111.6NPPB, PIK3C2A, OXT, ELANE
6thyroxine44 2411.6NPPB, PIK3C2A, OXT, ELANE
7prostacyclin4410.6ELANE, PIK3C2A, PPBP, NPPB
8phenylephrine44 28 11 2413.6ELANE, OXT, NPPB
9aprotinin44 1111.6ELANE, PPBP, NPPB
10warfarin44 49 11 2413.6PPBP, PIK3C2A, OXT
11aspirin44 49 28 2413.6NPPB, PPBP, OXT, ELANE
12haloperidol44 28 2 49 1114.6CYP11B2, PIK3C2A, NPPB
13epinephrine44 11 2412.6NPPB, PPBP, PIK3C2A, OXT, ELANE
14arachidonic acid44 28 11 2413.6SCGB1A1, PPBP, OXT, CYBA, SMPD1
15pge14410.6PPBP, PIK3C2A, OXT
16heparin44 28 11 2413.6PPBP, PIK3C2A, OXT, CLEC4A, ELANE
17catecholamine4410.5PIK3C2A, PPBP, NPPB
18sodium44 2411.5NPPB, PIK3C2A, CYP11B2, SLC5A6, ASIC5
19cholesterol44 28 11 2413.5PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A, SMPD1
20lactate4410.5NPPB, PPBP, PIK3C2A, OXT, ELANE
21serine4410.5OXT, ASIC5, SMPD1
22oxygen44 2411.5SCGB1A1, PIK3C2A, CYP11B2, CYBA, ASIC5, SMPD1
23superoxide44 2411.5NPPB, PPBP, PIK3C2A, CYBA, CLEC4A, SMPD1
24creatinine4410.5NPPB, SCGB1A1, PPBP, PIK3C2A, OXT
25aspartate4410.5SCGB1A1, PIK3C2A, OXT, SLC5A6, SMPD1
26arginine4410.5NPPB, PIK3C2A, OXT, CYP11B2, CLEC4A, SMPD1
27sodium nitroprusside4410.5ELANE, PIK3C2A, NPPB
28norepinephrine44 11 2412.5NPPB, PPBP, PIK3C2A, OXT, CYP11B2, SLC5A6
29progesterone44 59 28 11 2414.5NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
30cysteine4410.5CSAD, NPPB, PPBP, OXT, CLEC4A, SMPD1
31p0024410.4NPPB, SCGB1A1, CYP11B2
32lipid4410.4NPPB, SCGB1A1, PPBP, PIK3C2A, CYP11B2, CYBA
33glucose4410.4NPPB, PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A
34testosterone44 59 11 2413.4NPPB, PIK3C2A, OXT, CYP11B2, ELANE
35mibg4410.4PIK3C2A, NPPB
36doxorubicin44 49 1112.4NPPB, PIK3C2A, CYBA, SMPD1
37aldosterone28 11 2412.4CYP11B2, NPPB
38steroid4410.4NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
39hocl4410.4CYBA, ELANE
40nitric oxide44 11 2412.3CSAD, NPPB, SCGB1A1, PPBP, OXT, CYP11B2
41phosphorylcholine44 2411.3SMPD1, PPBP
42calcium44 49 11 2413.1SMPD1, SFTPA1, SFTPA2, S1PR2, NPPB, SCGB1A1
43atenolol44 28 49 11 2414.1NPPB, CYP11B2

GO Terms for genes affiliated with Pulmonary Edema

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16Gene Ontology
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Cellular components related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1SFTPA1, SFTPA2, NPPB, SCGB1A1, PPBP, OXT
2secretory granuleGO:0301419.9SCGB1A1, OXT, CYBA, ELANE

Biological processes related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cocaineGO:04222010.4SMPD1, OXT
2positive regulation of renal sodium excretionGO:03581510.1OXT, NPPB

Products for genes affiliated with Pulmonary Edema

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  • Antibodies
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  • Antibodies

Sources for Pulmonary Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet