MCID: PLM010
MIFTS: 50

Pulmonary Edema malady

Summaries for Pulmonary Edema

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pulmonary edema (American English), or oedema (British English; both words from the Greek... more...

MalaCards: Pulmonary Edema is related to acute myocardial infarction and adult respiratory distress syndrome. An important gene associated with Pulmonary Edema is NPPB (natriuretic peptide B), and among its related pathways are Signal regulatory protein (SIRP) family interactions and FOXA1 transcription factor network. The drugs mannitol hexanitrate and bumetanide and the compounds pge2 and thallium have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and spinal cord, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Pulmonary Edema

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

pulmonary edema 8 61


External Ids:

Disease Ontology8 DOID:11396
NCIt40 C26868
MeSH35 D011654

Related Diseases for Pulmonary Edema

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction30.5PIK3C2A, PPBP, NPPB
2adult respiratory distress syndrome30.5PPBP, ELANE
3pulmonary disease, chronic obstructive30.3ELANE, SCGB1A1, NPPB
4cardiogenic shock30.1PIK3C2A, NPPB
5bronchopulmonary dysplasia29.9ELANE, SCGB1A1
6bronchiolitis obliterans29.9SCGB1A1
7septic shock29.9NPPB, PIK3C2A, OXT, ELANE
8coronary artery disease,29.9NPPB, PPBP, PIK3C2A, CYBA, CLEC4A
9neuroleptic malignant syndrome29.9PIK3C2A
10spontaneous pneumothorax10.5
11brain edema10.4
12n syndrome10.4
13hypoxia10.4
14epiglottitis10.3
15acute mountain sickness10.3
16pulmonary function10.3
17rheumatic fever10.3
18toxic pneumonitis10.3
19pulmonary edema of mountaineers10.3
20croup10.2
21ovarian hyperstimulation syndrome10.2
22hypercalcemia10.2
23adult syndrome10.2
24bronchopneumonia10.2
25spinal cord injury10.2
26sepsis10.2
27hellp syndrome10.1
28primary pulmonary hypertension10.1
29cardiac tamponade10.1
30anuria10.1
31status epilepticus10.1
32pulmonary sarcoidosis10.1
33intracranial aneurysm10.1
34hypoglycemia10.1
35peripartum cardiomyopathy10.1
36hantavirus pulmonary syndrome10.1
37acute myocarditis10.1
38asthma10.1
39stress cardiomyopathy10.1
40young syndrome10.1
41fibrosing mediastinitis10.1
42swyer syndrome10.1
43swyer-james syndrome10.1
44sleep apnea10.1
45pulmonary capillary hemangiomatosis10.1
46sarcoidosis10.0SCGB1A1
47hypercholesterolemia10.0PPBP, CYBA
48stroke, ischemic10.0PPBP
49rhinitis10.0SCGB1A1
50allergic rhinitis10.0SCGB1A1, PPBP

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to pulmonary edema

Clinical Features for Pulmonary Edema

Drugs & Therapeutics for Pulmonary Edema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Edema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Edema

Search NIH Clinical Center for Pulmonary Edema

Search CenterWatch for Pulmonary Edema

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pulmonary Edema

Anatomical Context for Pulmonary Edema

Sources:
33MalaCards
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MalaCards organs/tissues related to Pulmonary Edema:

33
Lymph node, Brain, Spinal cord, Heart, Small intestine, Kidney, Liver, Lung, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Bronchial epithelium

Animal Models for Pulmonary Edema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Edema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9ELANE, SCGB1A1, PIK3C2A, OXT, CYP11B2, CYBA

Publications for Pulmonary Edema

Sources:
51PubMed
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Articles related to Pulmonary Edema:

(show top 50)    (show all 645)
idTitleAuthorsYear
1
Paramedic identification of acute pulmonary edema in a metropolitan ambulance service. (23484502)
2013
2
An unusual cause of unilateral pulmonary edema. (23588761)
2013
3
Reply to short-term mortality and CPAP in acute cardiac pulmonary edema: how and what can we be expecting? (24125111)
2013
4
Risk factors for the development of reexpansion pulmonary edema in patients with spontaneous pneumothorax. (23816309)
2013
5
Fatal re-expansion pulmonary edema in a young adult following tube thoracostomy for spontaneous pneumothorax. (23744860)
2013
6
Takutsubo cardiomyopathy and flash pulmonary edema in a trauma patient. (23899814)
2013
7
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. (23136043)
2012
8
Acute pulmonary edema secondary to upper airway obstruction by bilateral vocal cord paralysis after total thyroidectomy -A case report-. (22558509)
2012
9
Role of caveolin-1 expression in the pathogenesis of pulmonary edema in ventilator-induced lung injury. (23372929)
2012
10
Molecular pathology of pulmonary edema after injury in forensic autopsy cases. (22885909)
2012
11
An unusual transudative pleural effusion succeeded by pulmonary and brain edema and death. (22934227)
2012
12
The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema. (22925572)
2012
13
Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (21660235)
2011
14
The curious question of exercise-induced pulmonary edema. (21660232)
2011
15
Successful hybrid procedure in flash pulmonary edema. (21566313)
2011
16
Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m. (21718165)
2011
17
Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation. (22346035)
2011
18
Indian red scorpion venom-induced augmentation of cardio-respiratory reflexes and pulmonary edema involve the release of histamine. (21112349)
2011
19
Case report: Severe typhus group rickettsiosis complicated by pulmonary edema in a returning traveler from Indonesia. (22144455)
2011
20
Non-invasive pressure support ventilation and CPAP in cardiogenic pulmonary edema: a multicenter randomized study in the emergency department. (21136039)
2011
21
Bilateral reexpansion pulmonary edema associated with pleural empyema: a case report. (21394503)
2011
22
Interest of chest ultrasonography in the detection of exercise-induced pulmonary edema. (20960679)
2010
23
Re-expansion pulmonary edema following thoracentesis. (20643838)
2010
24
Fulminant unilateral pulmonary edema on the wrong side. (20376731)
2010
25
Shock and pulmonary edema secondary to severe acute hypercapnic acidosis. (21123752)
2010
26
Swimming-induced pulmonary edema in triathletes. (20887912)
2010
27
Unilateral re-expansion pulmonary edema: a rare complication following one-lung ventilation for minimal invasive mitral valve reconstruction. (19549047)
2009
28
Delayed onset of contralateral pulmonary edema following reexpansion pulmonary edema of a collapsed lung after video-assisted thoracoscopic surgery. (19527970)
2009
29
Negative-pressure acute tracheobronchial hemorrhage and pulmonary edema. (19685125)
2009
30
Negative pressure pulmonary edema: endobronchial intubation or acute lung injury in a predisposed patient? (19247751)
2009
31
Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters. (19351530)
2009
32
Acute pulmonary edema after pericardial drainage for cardiac tamponade. (19632445)
2009
33
Localized pulmonary edema in the right upper lobe associated with left atrial myxoma. (19712823)
2009
34
Negative pressure pulmonary edema in the coronary care unit. (18787726)
2008
35
Application of Pulse Contour Cardiac Output (PiCCO) system for adequate fluid management in a patient with severe reexpansion pulmonary edema. (19097967)
2008
36
Possible role of anesthesia level in the development of hypoxia-induced neurogenic pulmonary edema. (18785365)
2008
37
An unusual case of acute rheumatic fever presenting with unilateral pulmonary edema. (19227426)
2008
38
Ipsilateral re-expansion pulmonary edema in a neurosurgical patient--a case report. (18942253)
2008
39
Maternal pulmonary edema during fetoscopic surgery. (19020148)
2008
40
Unilateral pulmonary edema and acute rheumatic fever. (17450381)
2008
41
Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. (17426196)
2007
42
Possible increased risk of pulmonary edema in patients with hepatorenal syndrome on adding octreotide to albumin / noradrenaline therapies. (17496406)
2007
43
Unilateral pulmonary edema: unusual presentation of acute rheumatic fever. (16132283)
2005
44
Two episodes of anuria and acute pulmonary edema in a losartan-treated patient with solitary kidney. (14685757)
2004
45
Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edema. (14555664)
2003
46
Pulmonary edema complicating prostacyclin therapy in pulmonary hypertension associated with scleroderma: a case of pulmonary capillary hemangiomatosis. (10728766)
2000
47
Noncardiogenic pulmonary edema as the chief manifestation of a pheochromocytoma: a case report of MEN 2A with pedigree analysis of the RET proto-oncogene. (10526879)
1999
48
Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. (8797614)
1996
49
Hypoxia-induced ANP secretion in subjects susceptible to high-altitude pulmonary edema. (1410844)
1992
50
Pulmonary edema in severe pre-eclampsia (a case report). (2634761)
1989

Genetic Variations for Pulmonary Edema

Expression for genes affiliated with Pulmonary Edema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for genes affiliated with Pulmonary Edema

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Pulmonary Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SFTPA2, SFTPA1
210.3SCGB1A1, SFTPA2, SFTPA1
3
Hide members
10.3CLDN18, SFTPA2, SFTPA1

Compounds for genes affiliated with Pulmonary Edema

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Pulmonary Edema according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1pge24510.8SMPD1
2thallium4510.7NPPB, PIK3C2A
3ptca4510.7NPPB, PPBP, PIK3C2A
4nitrate4510.7PIK3C2A, PPBP, NPPB
5nitroglycerin45 1111.6NPPB, PIK3C2A, OXT, ELANE
6thyroxine45 2411.6NPPB, PIK3C2A, OXT, ELANE
7prostacyclin4510.6ELANE, PIK3C2A, PPBP, NPPB
8phenylephrine45 29 11 2413.6ELANE, OXT, NPPB
9aprotinin45 1111.6ELANE, PPBP, NPPB
10warfarin45 50 11 2413.6PPBP, PIK3C2A, OXT
11aspirin45 50 29 2413.6NPPB, PPBP, OXT, ELANE
12haloperidol45 29 2 50 1114.6CYP11B2, PIK3C2A, NPPB
13epinephrine45 11 2412.6NPPB, PPBP, PIK3C2A, OXT, ELANE
14arachidonic acid45 29 11 2413.6SCGB1A1, PPBP, OXT, CYBA, SMPD1
15pge14510.6PPBP, PIK3C2A, OXT
16heparin45 29 11 2413.6PPBP, PIK3C2A, OXT, CLEC4A, ELANE
17catecholamine4510.5PIK3C2A, PPBP, NPPB
18sodium45 2411.5NPPB, PIK3C2A, CYP11B2, SLC5A6, ASIC5
19cholesterol45 29 11 2413.5PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A, SMPD1
20lactate4510.5NPPB, PPBP, PIK3C2A, OXT, ELANE
21serine4510.5OXT, ASIC5, SMPD1
22oxygen45 2411.5SCGB1A1, PIK3C2A, CYP11B2, CYBA, ASIC5, SMPD1
23superoxide45 2411.5NPPB, PPBP, PIK3C2A, CYBA, CLEC4A, SMPD1
24creatinine4510.5NPPB, SCGB1A1, PPBP, PIK3C2A, OXT
25aspartate4510.5SCGB1A1, PIK3C2A, OXT, SLC5A6, SMPD1
26arginine4510.5NPPB, PIK3C2A, OXT, CYP11B2, CLEC4A, SMPD1
27sodium nitroprusside4510.5ELANE, PIK3C2A, NPPB
28norepinephrine45 11 2412.5NPPB, PPBP, PIK3C2A, OXT, CYP11B2, SLC5A6
29progesterone45 60 29 11 2414.5NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
30cysteine4510.5CSAD, NPPB, PPBP, OXT, CLEC4A, SMPD1
31p0024510.4NPPB, SCGB1A1, CYP11B2
32lipid4510.4NPPB, SCGB1A1, PPBP, PIK3C2A, CYP11B2, CYBA
33glucose4510.4NPPB, PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A
34testosterone45 60 11 2413.4NPPB, PIK3C2A, OXT, CYP11B2, ELANE
35mibg4510.4PIK3C2A, NPPB
36doxorubicin45 50 1112.4NPPB, PIK3C2A, CYBA, SMPD1
37aldosterone29 11 2412.4CYP11B2, NPPB
38steroid4510.4NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
39hocl4510.4CYBA, ELANE
40nitric oxide45 11 2412.3CSAD, NPPB, SCGB1A1, PPBP, OXT, CYP11B2
41phosphorylcholine45 2411.3SMPD1, PPBP
42calcium45 50 11 2413.1SMPD1, SFTPA1, SFTPA2, S1PR2, NPPB, SCGB1A1
43atenolol45 29 50 11 2414.1NPPB, CYP11B2

GO Terms for genes affiliated with Pulmonary Edema

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1SFTPA1, SFTPA2, NPPB, SCGB1A1, PPBP, OXT
2secretory granuleGO:0301419.9SCGB1A1, OXT, CYBA, ELANE

Biological processes related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cocaineGO:04222010.4SMPD1, OXT
2positive regulation of renal sodium excretionGO:03581510.1OXT, NPPB

Products for genes affiliated with Pulmonary Edema

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Edema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet