MCID: PLM010
MIFTS: 48

Pulmonary Edema malady

Respiratory diseases category
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Summaries for Pulmonary Edema

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Pulmonary edema (American English), or oedema (British English; both words from the Greek ??????), is... more...

MalaCards: Pulmonary Edema is related to hypertension and myocardial infarction. An important gene associated with Pulmonary Edema is NPPB (natriuretic peptide B), and among its related pathways are Pertussis and FOXA1 transcription factor network. The drugs mannitol hexanitrate and bumetanide and the compounds imidapril and aldosterone have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial.

Aliases & Classifications for Pulmonary Edema

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Sources:
8Disease Ontology, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary edema 8 62


External Ids:

Disease Ontology8 DOID:11396
MeSH35 D011654
NCIt40 C26868

Related Diseases for Pulmonary Edema

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to pulmonary edema

Symptoms for Pulmonary Edema

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Drugs & Therapeutics for Pulmonary Edema

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Edema

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Edema:

33
Lung, Heart, Endothelial, Brain, Kidney, Spinal cord, Liver, Bronchial epithelium, Lymph node

Animal Models for Pulmonary Edema or affiliated genes

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Publications for Pulmonary Edema

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52PubMed
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Articles related to Pulmonary Edema:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Atrial natriuretic peptide attenuates agonist-induced pulmonary edema in mice with targeted disruption of the gene for natriuretic peptide receptor-A. (23195629)
2013
2
Paramedic identification of acute pulmonary edema in a metropolitan ambulance service. (23484502)
2013
3
Negative pressure pulmonary edema related to bronchospasm during anesthetic recovery. (23904949)
2013
4
High-altitude pulmonary edema: diagnosis, prevention, and treatment. (23478563)
2013
5
Rupture of a Noncoronary Sinus of Valsalva Aneurysm into the Left Atrium: A Rare Cause of Acute Pulmonary Edema. (24006888)
2013
6
Reexpansion pulmonary edema in children. (24142327)
2013
7
Noncardiogenic pulmonary edema. (23532787)
2012
8
Preoperative neurogenic pulmonary edema: A dilemma for decision making. (22557750)
2012
9
Subarachnoid hemorrhage complicated with neurogenic pulmonary edema and takotsubo-like cardiomyopathy. (22362283)
2012
10
Noninvasive ventilation in pulmonary edema complicating acute myocardial infarction. (22850288)
2012
11
Hemoptysis and pulmonary edema in a scuba diver using diclofenac. (22354373)
2012
12
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. (23136043)
2012
13
Protection against LPS-induced pulmonary edema through the attenuation of protein tyrosine phosphatase-1B oxidation. (22180868)
2012
14
Non-cardiogenic mechanisms for the pulmonary edema induced by scorpion venom. (22521599)
2012
15
Recurrent pulmonary edema secondary to elongated soft palate in a cat. (22398461)
2012
16
Acute pulmonary edema and airway hemorrhage in a goat during sevoflurane anesthesia. (21274835)
2011
17
Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (21660235)
2011
18
Involvement of nitric oxide pathways in neurogenic pulmonary edema induced by vagotomy. (21808876)
2011
19
Diagnostic utility of C-reactive protein combined with brain natriuretic peptide in acute pulmonary edema: a cross sectional study. (21696613)
2011
20
Interest of chest ultrasonography in the detection of exercise-induced pulmonary edema. (20960679)
2010
21
Long-term survival and quality of life after transfusion-associated pulmonary edema in critically ill medical patients. (19837827)
2010
22
Endothelial nitric oxide synthase gene polymorphisms associated with susceptibility to high altitude pulmonary edema in Chinese railway construction workers at Qinghai-Tibet over 4 500 meters above sea level. (21232181)
2010
23
Inhibition of secretory phospholipase A2 activity attenuates acute cardiogenic pulmonary edema induced by isoproterenol infusion in mice after myocardial infarction. (20625313)
2010
24
Effectiveness of human atrial natriuretic peptide supplementation in pulmonary edema patients using the pulse contour cardiac output system. (20376887)
2010
25
Hybrid renal replacement treatment in acute pulmonary edema with acute kidney injury following multiple wasp stings: a report of 3 cases. (20689272)
2010
26
Prognostic indicators in patients presenting with acute cardiogenic pulmonary edema treated with CPAP: it's not the acid that matters, it's back to basics. (21138600)
2010
27
Unilateral re-expansion pulmonary edema: a rare complication following one-lung ventilation for minimal invasive mitral valve reconstruction. (19549047)
2009
28
What is your diagnosis? Cardiogenic pulmonary edema. (19284334)
2009
29
The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions. (19675280)
2009
30
Radiographic features of cardiogenic pulmonary edema in dogs with mitral regurgitation: 61 cases (1998-2007). (19878003)
2009
31
Negative pressure pulmonary edema complicating an electrophysiological study. (19446350)
2009
32
Hyperacute pulmonary edema complicating rituximab infusion. (19237066)
2009
33
Re-expansion pulmonary edema following treatment of spontaneous pneumothorax during oral surgery. (19462219)
2009
34
Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. (19572988)
2009
35
Tako-tsubo cardiomyopathy presenting with acute pulmonary edema. (19187409)
2009
36
Noninvasive positive pressure ventilation: effect on mortality in acute cardiogenic pulmonary edema: a pragmatic meta-analysis. (19694215)
2009
37
Pulmonary edema after extensive radiofrequency ablation for atrial fibrillation. (18179523)
2008
38
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
39
Ipsilateral reexpansion pulmonary edema after drainage of a spontaneous pneumothorax: a case report. (17903268)
2007
40
Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. (17426196)
2007
41
Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. (17435079)
2007
42
Possible increased risk of pulmonary edema in patients with hepatorenal syndrome on adding octreotide to albumin / noradrenaline therapies. (17496406)
2007
43
B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema. (16691132)
2006
44
Mechanism of fulminant pulmonary edema caused by enterovirus 71. (15227628)
2004
45
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. (14704790)
2004
46
Research on the relationship between expression of VEGF and high altitude pulmonary edema]. (11236633)
2000
47
Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. (9700111)
1998
48
Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. (1428125)
1992
49
Serum-erythropoietin concentration during acute cardiogenic pulmonary edema. (2014919)
1991
50
Capillary leak syndrome with pulmonary edema. (5035983)
1972

Variations for Pulmonary Edema

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Expression for genes affiliated with Pulmonary Edema

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for genes affiliated with Pulmonary Edema

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Pulmonary Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SFTPA2, SFTPA1
2
Show member pathways
FOXA transcription factor networks38
9.6SFTPA2, SFTPA1
39.0SFTPA2, SFTPA1, CYBA

Compounds for genes affiliated with Pulmonary Edema

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience, 3BitterDB
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Compounds related to Pulmonary Edema according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1imidapril45 5111.1CYP11B2, NPPB
2aldosterone29 24 1112.1NPPB, CYP11B2
3atenolol45 51 29 24 1114.1NPPB, CYP11B2
4candesartan45 51 29 1113.1NPPB, CYP11B2
5spironolactone45 61 29 51 1114.1CYP11B2, NPPB
6ang ii4510.1CYP11B2, NPPB
7losartan45 51 29 1113.0NPPB, CYP11B2
8phosphoramidon45 1111.0NPPB, ELANE
9nitroglycerin45 1111.0NPPB, ELANE
10captopril45 61 51 29 1113.9ELANE, NPPB
11haloperidol45 51 29 3 1113.9NPPB, CYP11B2
12pentoxifylline45 1110.9ELANE, NPPB
13phenylephrine45 29 24 1112.9NPPB, ELANE
14aprotinin45 1110.9ELANE, NPPB
15p002459.8CYP11B2, NPPB
16sodium nitroprusside459.8ELANE, NPPB
17hocl459.7ELANE, CYBA
18n-formylmethionyl-leucylphenylalanine459.6ELANE, CYBA
19norepinephrine45 24 1111.6NPPB, ELANE, CYP11B2
20leupeptin459.5ELANE, SMPD1
21hydrocortisone45 3 61 1112.4ELANE, CYP11B2
22testosterone45 61 24 1112.4CYP11B2, ELANE, NPPB
23dexamethasone45 51 29 1112.1NPPB, CYP11B2, CYBA
24pge2459.1SMPD1, ELANE, NPPB
25doxorubicin45 51 1111.0CYBA, SMPD1, NPPB
26arginine458.9NPPB, SMPD1, CYP11B2
27cholesterol45 29 24 1111.8SMPD1, CYP11B2, CYBA
28h2o2458.7ELANE, SMPD1, CYBA
29oligonucleotide458.7SMPD1, CYP11B2, CYBA
30nitric oxide45 24 1110.7CYBA, CYP11B2, SMPD1, NPPB
31glucose458.6CYBA, CYP11B2, SMPD1, NPPB
32Water248.6CYP11B2, SMPD1, NPPB
33lipid458.6NPPB, SMPD1, CYP11B2, CYBA
34superoxide45 249.6CYBA, SMPD1, ELANE, NPPB
35oxygen45 249.2NPPB, ELANE, SMPD1, CYP11B2, CYBA
36calcium45 51 24 1110.8CYBA, CYP11B2, SFTPA1, SFTPA2, SMPD1, NPPB

GO Terms for genes affiliated with Pulmonary Edema

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16Gene Ontology
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Cellular components related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.5SFTPA2, SFTPA1
2secretory granuleGO:0301419.0CYBA, ELANE
3extracellular regionGO:0055768.7NPPB, ELANE, SFTPA2, SFTPA1
4extracellular spaceGO:0056158.4NPPB, SMPD1, SFTPA2, SFTPA1

Biological processes related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.6SFTPA2, SFTPA1

Molecular functions related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.6SFTPA2, SFTPA1
2heme bindingGO:0200379.1CYP11B2, CYBA

Products for genes affiliated with Pulmonary Edema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Edema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet