MCID: PLM010
MIFTS: 50

Pulmonary Edema malady

Summaries for Pulmonary Edema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pulmonary edema (American English), or oedema (British English; both words from the Greek... more...

MalaCards: Pulmonary Edema is related to hypertension and myocardial infarction. An important gene associated with Pulmonary Edema is NPPB (natriuretic peptide B), and among its related pathways are Signal regulatory protein (SIRP) family interactions and FOXA1 transcription factor network. The drugs bumetanide and ethacrynate sodium and the compounds pge2 and thallium have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Pulmonary Edema

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

pulmonary edema 8 60


External Ids:

Disease Ontology8 DOID:11396
NCIt39 C26868
MeSH34 D011654

Related Diseases for Pulmonary Edema

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.8CYBA, CYP11B2, PPBP, NPPB
2myocardial infarction30.5NPPB, PPBP, PIK3C2A, CYP11B2, CYBA
3acute myocardial infarction30.5PIK3C2A, PPBP, NPPB
4adult respiratory distress syndrome30.5PPBP, ELANE
5pneumonia30.3SCGB1A1, PIK3C2A, SMPD1, ELANE
6congestive heart failure30.2CYP11B2, PIK3C2A, PPBP, NPPB
7sarcoidosis30.1SCGB1A1
8respiratory failure30.1CSAD, SCGB1A1, PIK3C2A
9disseminated intravascular coagulation30.1PPBP, PIK3C2A, OXT, ELANE
10ischemia30.1NPPB, PIK3C2A
11bronchiolitis obliterans29.9SCGB1A1
12coronary artery disease29.9NPPB, PPBP, PIK3C2A, CYBA, CLEC4A
13neuroleptic malignant syndrome29.9PIK3C2A
14pneumothorax10.5
15brain edema10.4
16epiglottitis10.3
17pulmonary embolism10.3
18rheumatic fever10.2
19toxic pneumonitis10.2
20pulmonary edema of mountaineers10.2
21cerebritis10.2
22croup10.2
23ovarian hyperstimulation syndrome10.2
24hypercalcemia10.2
25adult syndrome10.2
26bronchopneumonia10.2
27mediastinitis10.2
28hellp syndrome10.1
29primary pulmonary hypertension10.1
30cardiac tamponade10.1
31anuria10.1
32status epilepticus10.1
33pulmonary sarcoidosis10.1
34intracranial aneurysm10.1
35hypoglycemia10.1
36peripartum cardiomyopathy10.1
37hantavirus pulmonary syndrome10.1
38acute myocarditis10.1
39asthma10.1
40diabetes mellitus10.1
41encephalitis10.1
42hyperparathyroidism10.1
43malaria10.1
44meningitis10.1
45multiple sclerosis10.1
46myocarditis10.1
47acute mountain sickness10.1
48hypercholesterolemia10.0PPBP, CYBA
49stroke, ischemic10.0PPBP
50rhinitis10.0SCGB1A1

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to pulmonary edema

Clinical Features for Pulmonary Edema

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Drugs & Therapeutics for Pulmonary Edema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Edema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Edema

Search NIH Clinical Center for Pulmonary Edema

Search CenterWatch for Pulmonary Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Edema:

32
Lung, Heart, Endothelial, Brain, Kidney, Spinal cord, Liver, Bronchial epithelium, Lymph node

Animal Models for Pulmonary Edema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9ELANE, SCGB1A1, PIK3C2A, OXT, CYP11B2, CYBA

Publications for Pulmonary Edema

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50PubMed
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Articles related to Pulmonary Edema:

(show top 50)    (show all 643)
idTitleAuthorsYear
1
The mechanism of neurogenic pulmonary edema in epilepsy. (24142459)
2014
2
High-altitude pulmonary edema: diagnosis, prevention, and treatment. (23478563)
2013
3
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema. (24140156)
2013
4
Neurogenic pulmonary edema and variations of hemodynamic volumetric parameters in children following head trauma. (23811625)
2013
5
Non-cardiogenic mechanisms for the pulmonary edema induced by scorpion venom. (22521599)
2012
6
Posttraumatic anomalous pulmonary edema. (22314584)
2012
7
Neurogenic pulmonary edema: successful treatment with IV phentolamine. (22396565)
2012
8
Re-expansion pulmonary edema in a patient with total pneumothorax: a hazardous outcome. (22627959)
2012
9
Reexpansion Pulmonary Edema following Laparoscopy-Assisted Distal Gastrectomy for a Patient with Early Gastric Cancer: A Case Report. (23227412)
2012
10
An unusual cause of photographic negative of pulmonary edema: Sarcoidosis. (23243360)
2012
11
Unilateral lobar pulmonary edema. (23547417)
2012
12
Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders. (22984459)
2012
13
Contribution of I+ - and I^ -Adrenergic Mechanisms to the Development of Pulmonary Edema. (24278744)
2012
14
Inositol-trisphosphate reduces alveolar apoptosis and pulmonary edema in neonatal lung injury. (22403805)
2012
15
Diagnosis, prevention and management of postoperative pulmonary edema. (23439791)
2012
16
Three-view bedside ultrasound for the differentiation of acute respiratory distress syndrome from cardiogenic pulmonary edema. (21871756)
2012
17
Acute neurogenic pulmonary edema following electroconvulsive therapy: a case report. (22516213)
2012
18
Diagnostic utility of C-reactive protein combined with brain natriuretic peptide in acute pulmonary edema: a cross sectional study. (21696613)
2011
19
A fibrous ring and a subaortic fibrous process conforming a tunnel obstruction in patient with recurrent pulmonary edema. (22134473)
2011
20
Amiodarone-induced pulmonary toxicity mimicking acute pulmonary edema. (19924000)
2011
21
Continuous positive airway pressure for cardiogenic pulmonary edema: a randomized study. (20825901)
2011
22
Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat. (21296072)
2011
23
Mitral regurgitation and pulmonary edema. (21369771)
2011
24
Sodium tanshinone iia sulfonate attenuates seawater aspiration-induced acute pulmonary edema by up-regulating Na(+),K(+)-ATPase activity. (21797801)
2011
25
Inhibition of secretory phospholipase A2 activity attenuates acute cardiogenic pulmonary edema induced by isoproterenol infusion in mice after myocardial infarction. (20625313)
2010
26
Meta-analysis: Noninvasive ventilation in acute cardiogenic pulmonary edema. (20439577)
2010
27
Noninvasive positive pressure ventilation in patients with perioperative negative pressure pulmonary edema. (20221646)
2010
28
Landiolol, an ultra short acting beta1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats. (20039077)
2010
29
Effect of cardiogenic pulmonary edema on defibrillation efficacy. (19155073)
2010
30
Acute pulmonary edema secondary to pregnancy in a patient with the mitochondrial disease MELAS. (20450859)
2010
31
Bilateral upper lobe pulmonary edema during gynecologic laparoscopic surgery in the Trendelenberg position -A case report-. (21286430)
2010
32
What is your diagnosis? Cardiogenic pulmonary edema. (19284334)
2009
33
Evaluation of a thoracic ultrasound training module for the detection of pneumothorax and pulmonary edema by prehospital physician care providers. (19138397)
2009
34
Genetic delivery of bevacizumab to suppress vascular endothelial growth factor-induced high-permeability pulmonary edema. (19254174)
2009
35
Reactive species and pulmonary edema. (20305724)
2009
36
The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat. (19095854)
2009
37
Flash pulmonary edema in a post arterial switch operation - High flow oxygen as a treatment modality. (20808637)
2009
38
Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. (19481479)
2009
39
New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax. (19857415)
2009
40
Protective efficiacy of taurine against pulmonary edema progression: experimental study. (18957088)
2008
41
Hemorrhagic stroke associated with pulmonary edema and catastrophic cardiac failure. (18947007)
2008
42
The rapidity of intracranial pressure increase reflects the grade of neurogenic pulmonary edema. (18929295)
2008
43
Sudden death in toddlers with viral meningitis, massive cerebral edema, and neurogenic pulmonary edema and hemorrhage: report of two cases. (18001157)
2007
44
Heterozygotes of NOS3 polymorphisms contribute to reduced nitrogen oxides in high-altitude pulmonary edema. (17099031)
2006
45
Pulmonary edema related to administration of 15-methyl-prostaglandin F2alpha during a cesarean section]. (15072404)
2004
46
Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway. (14561241)
2003
47
Vascular endothelial growth factor in patients with high-altitude pulmonary edema. (12524373)
2003
48
High-altitude pulmonary edema: potential protection by red wine. (12616811)
2002
49
Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema. (9628235)
1998
50
Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. (1428125)
1992

Genetic Variations for Pulmonary Edema

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Expression for genes affiliated with Pulmonary Edema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for genes affiliated with Pulmonary Edema

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Pulmonary Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SFTPA2, SFTPA1
210.3SCGB1A1, SFTPA2, SFTPA1
3
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10.3CLDN18, SFTPA2, SFTPA1

Compounds for genes affiliated with Pulmonary Edema

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Pulmonary Edema according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1pge24410.8SMPD1
2thallium4410.7NPPB, PIK3C2A
3ptca4410.7NPPB, PPBP, PIK3C2A
4nitrate4410.7PIK3C2A, PPBP, NPPB
5nitroglycerin44 1111.6NPPB, PIK3C2A, OXT, ELANE
6thyroxine44 2411.6NPPB, PIK3C2A, OXT, ELANE
7prostacyclin4410.6ELANE, PIK3C2A, PPBP, NPPB
8phenylephrine44 28 11 2413.6ELANE, OXT, NPPB
9aprotinin44 1111.6ELANE, PPBP, NPPB
10warfarin44 49 11 2413.6PPBP, PIK3C2A, OXT
11aspirin44 49 28 2413.6NPPB, PPBP, OXT, ELANE
12haloperidol44 28 2 49 1114.6CYP11B2, PIK3C2A, NPPB
13epinephrine44 11 2412.6NPPB, PPBP, PIK3C2A, OXT, ELANE
14arachidonic acid44 28 11 2413.6SCGB1A1, PPBP, OXT, CYBA, SMPD1
15pge14410.6PPBP, PIK3C2A, OXT
16heparin44 28 11 2413.6PPBP, PIK3C2A, OXT, CLEC4A, ELANE
17catecholamine4410.5PIK3C2A, PPBP, NPPB
18sodium44 2411.5NPPB, PIK3C2A, CYP11B2, SLC5A6, ASIC5
19cholesterol44 28 11 2413.5PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A, SMPD1
20lactate4410.5NPPB, PPBP, PIK3C2A, OXT, ELANE
21serine4410.5OXT, ASIC5, SMPD1
22oxygen44 2411.5SCGB1A1, PIK3C2A, CYP11B2, CYBA, ASIC5, SMPD1
23superoxide44 2411.5NPPB, PPBP, PIK3C2A, CYBA, CLEC4A, SMPD1
24creatinine4410.5NPPB, SCGB1A1, PPBP, PIK3C2A, OXT
25aspartate4410.5SCGB1A1, PIK3C2A, OXT, SLC5A6, SMPD1
26arginine4410.5NPPB, PIK3C2A, OXT, CYP11B2, CLEC4A, SMPD1
27sodium nitroprusside4410.5ELANE, PIK3C2A, NPPB
28norepinephrine44 11 2412.5NPPB, PPBP, PIK3C2A, OXT, CYP11B2, SLC5A6
29progesterone44 59 28 11 2414.5NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
30cysteine4410.5CSAD, NPPB, PPBP, OXT, CLEC4A, SMPD1
31p0024410.4NPPB, SCGB1A1, CYP11B2
32lipid4410.4NPPB, SCGB1A1, PPBP, PIK3C2A, CYP11B2, CYBA
33glucose4410.4NPPB, PPBP, PIK3C2A, CYP11B2, CYBA, CLEC4A
34testosterone44 59 11 2413.4NPPB, PIK3C2A, OXT, CYP11B2, ELANE
35mibg4410.4PIK3C2A, NPPB
36doxorubicin44 49 1112.4NPPB, PIK3C2A, CYBA, SMPD1
37aldosterone28 11 2412.4CYP11B2, NPPB
38steroid4410.4NPPB, SCGB1A1, PIK3C2A, OXT, CYP11B2
39hocl4410.4CYBA, ELANE
40nitric oxide44 11 2412.3CSAD, NPPB, SCGB1A1, PPBP, OXT, CYP11B2
41phosphorylcholine44 2411.3SMPD1, PPBP
42calcium44 49 11 2413.1SMPD1, SFTPA1, SFTPA2, S1PR2, NPPB, SCGB1A1
43atenolol44 28 49 11 2414.1NPPB, CYP11B2

GO Terms for genes affiliated with Pulmonary Edema

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16Gene Ontology
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Cellular components related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1SFTPA2, NPPB, SCGB1A1, PPBP, OXT, SMPD1
2secretory granuleGO:0301419.9ELANE, CYBA, OXT, SCGB1A1

Biological processes related to Pulmonary Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cocaineGO:04222010.4SMPD1, OXT
2positive regulation of renal sodium excretionGO:03581510.1OXT, NPPB

Products for genes affiliated with Pulmonary Edema

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  • Antibodies
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Sources for Pulmonary Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet