MCID: PLM033
MIFTS: 68

Pulmonary Embolism malady

Cardiovascular diseases category

Summaries for Pulmonary Embolism

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Embolism, also known as pulmonary artery embolism, is related to hypertension and thrombophlebitis. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs heparin and heparin sodium and the compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are vision/eye and reproductive system.

CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:63 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Pulmonary Embolism

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9PLAT, F2, MTHFR, F5, NPPB
2thrombophlebitis30.9APOH
3patent foramen ovale30.8F5
4thrombocytopenia30.7SERPINC1, F2, F3, FGA, PF4, F10
5protein s deficiency30.7SERPINC1, F5, F9
6thrombophilia30.6SERPINF2, SERPINC1, PLAT, F2, F3, FGA
7myocardial infarction30.6SERPINF2, SERPINC1, PLAT, F3, FGA, FGB
8endocarditis30.5F10
9pneumonia30.5FGA
10stroke, ischemic30.5F2, F5
11antithrombin iii deficiency30.5SERPINC1, F2, F10, MTHFR, F5, APOH
12polycythemia vera30.4PF4
13protein c deficiency30.4SERPINC1, F2, MTHFR, F5, APOH, F9
14hyperhomocysteinemia30.4SERPINC1, PLAT, F2, CBS, MTHFR, F5
15disseminated intravascular coagulation30.4SERPINF2, SERPINC1, PLAT, F2, F3, FGA
16hepatitis30.3F2, F10, F9
17antiphospholipid syndrome30.3SERPINC1, PLAT, F2, F3, PF4, F10
18obesity30.2CBS, FABP3
19adenocarcinoma30.2PF4, F13A1, TNXA
20nephrotic syndrome30.2SERPINF2, SERPINC1, FGA, F9
21arthritis30.1F10
22myeloma30.1PF4
23respiratory failure30.1SERPINC1, F3
24sagittal sinus thrombosis30.1SERPINC1, F5
25coronary thrombosis30.1SERPINC1, PLAT, F3
26dilated cardiomyopathy30.1FGA, FABP3, NPPB, TNNI3
27factor xi deficiency30.1F2, F3, F5, F9
28von willebrand's disease30.1F2, F3, F5, F9
29rheumatoid arthritis30.1PF4, F13A1, F10, MTHFR, APOH
30peritonitis29.9F2
31hepatitis a29.9F2
32myocarditis29.9NPPB, TNNI3
33factor v deficiency29.9F2, F3, F5
34deficiency anemia29.9F2, F3, F9
35portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5
36acute leukemia29.9FGA, MTHFR
37prothrombin deficiency29.9SERPINC1, F2, F5, APOH
38hepatic vein thrombosis29.9SERPINC1, PLAT
39factor vii deficiency29.9SERPINC1, F2, F3, F10, F5, F9
40ischemia29.9PLAT, FGA, PF4, CBS, F10, FABP3
41liver cirrhosis29.9SERPINF2, SERPINC1, F2, F3, F10, F9
42thrombocytosis29.9SERPINF2, SERPINC1, F2, F3, FGA, PF4
43hypertrophic cardiomyopathy29.9TNNI3
44leukemia29.9SERPINF2, FGA, PF4, CBS, F10, MTHFR
45coronary artery disease29.9PLAT, F3, FGA, PF4, CBS, F10
46acute myocardial infarction29.9SERPINF2, SERPINC1, PLAT, F3, FGA, PF4
47factor v leiden thrombophilia29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
48thromboembolism29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
49venous thrombosis29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
50pulmonary embolism and infarction10.8

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Clinical Features for Pulmonary Embolism

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Drugs & Therapeutics for Pulmonary Embolism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Pulmonary Embolism

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Anatomical Context for Pulmonary Embolism

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Embolism:

32
Lung, Heart, Brain, Testes, Liver, Ovary, Breast, Bone, Pancreas, Thyroid, Kidney, Colon, Prostate, Spinal cord, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Embolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2PLAT, CBS, FABP3
2MP:000538910.2MTHFR, F10, CBS, FGA, SERPINC1
3MP:000537010.1SERPINC1, FGA, CBS, F5, FABP3, F9
4MP:000538510.1F2, F9, TNNI3, NPPB, FABP3, F10
5MP:000539710.0F9, F13A1, CBS, PF4, FGA, F3
6MP:001077110.0FABP3, CBS, FGA, F2
7MP:00107689.8MTHFR, F5, FABP3, APOH, TNNI3, F9
8MP:00053769.8F10, MTHFR, F5, FABP3, APOH, F9

Publications for Pulmonary Embolism

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50PubMed
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Articles related to Pulmonary Embolism:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
Pulmonary embolism risk stratification: where are we heading? (24381322)
2014
2
A leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. (24152686)
2014
3
Point: should systemic lytic therapy be used for submassive pulmonary embolism? Yes. (23381309)
2013
4
Benefits of texture analysis of dual energy CT for Computer-Aided pulmonary embolism detection. (24110602)
2013
5
A Rare Case of Acute Pulmonary Embolism after Coronary Angiography due to Sand Bag Compression. (24436623)
2013
6
Current status of the use of inferior vena cava filters in cases of pulmonary embolism in CCUs: From the Tokyo CCU Network. (24239194)
2013
7
Metabolic syndrome increases risk for pulmonary embolism after hip and knee arthroplasty. (23986276)
2013
8
Hestia criteria can safely select patients with pulmonary embolism for outpatient treatment irrespective of right ventricular function. (23336721)
2013
9
Agnogenic massive pulmonary embolism with syncope as initial symptom: A case report and review of the literature. (23737910)
2013
10
Matrix metalloproteinases as drug targets in acute pulmonary embolism. (23316966)
2013
11
Optimal monochromatic energy levels in spectral CT pulmonary angiography for the evaluation of pulmonary embolism. (23667583)
2013
12
Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry. (23865769)
2013
13
Right ventricular assessment by tissue-Doppler echocardiography in acute pulmonary embolism. (23657266)
2013
14
Influence of C-reactive protein levels and age on the value of D-dimer in diagnosing pulmonary embolism. (24164492)
2013
15
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study. (23778403)
2013
16
Ultrasound Assessment of Pulmonary Embolism in Patients Receiving Computerized Tomography Pulmonary Angiography. (24178672)
2013
17
Pulmonary embolism and deep vein thrombosis related to oral contraceptive use. (24328015)
2013
18
Massive pulmonary embolism due to giant right ventricle thrombus. (24197601)
2013
19
Improved Coding of Postoperative Deep Vein Thrombosis and Pulmonary Embolism in Administrative Data (AHRQ Patient Safety Indicator 12) After Introduction of New ICD-9-CM Diagnosis Codes. (23552433)
2013
20
Aortic intramural hematoma after thrombolysis in a patient with acute massive pulmonary embolism. (24009461)
2013
21
Fibrinolytic inhibitors and fibrin characteristics determine a hypofibrinolytic state in patients with pulmonary embolism. (23306795)
2013
22
Cell-free DNA as a promising marker for risk stratification of pulmonary embolism. (24245555)
2013
23
Are all pulmonary embolism clinical decision rules equal? (23544863)
2013
24
Does the mean platelet volume have any importance in patients with acute pulmonary embolism? (23807041)
2013
25
Pulmonary embolism related to amisulpride treatment: a case report. (23533901)
2013
26
Efficacy and safety of tenecteplase in pulmonary embolism. (23975441)
2013
27
Acute pulmonary embolism: external validation of an integrated risk stratification model. (23764909)
2013
28
The additional value of the CRP test in patients in whom the primary care physician excluded pulmonary embolism. (23577661)
2013
29
A case of cryptogenic stroke associated with patent foramen ovale coexisting with pulmonary embolisms, deep vein thromboses, and renal artery infarctions. (23323125)
2012
30
Right bundle branch block on alternate beats during acute pulmonary embolism. (21762261)
2011
31
Massive pulmonary embolism and acute limb ischaemia in a patient of hereditary spherocytosis and patent foramen ovale. (20619736)
2010
32
Images in cardiovascular medicine. Solitary pulmonary artery intima sarcoma manifesting as pulmonary embolism and subacute cor pulmonale. (19948995)
2009
33
Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism: a systematic review and meta-analysis. (18556626)
2008
34
Percutaneous rheolytic thrombectomy with AngioJet for pulmonary embolism: methods and results in the experience of a high-volume center]. (18678226)
2008
35
Post-intubation pulmonary embolism and tracheal stenosis: a case report and review of the literature. (18579367)
2008
36
Electroconvulsive therapy in a schizophrenic patient with neuroleptic malignant syndrome and pulmonary embolism: a case report. (20711323)
2007
37
Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism. (16698008)
2006
38
Acute right bundle branch block as a presenting sign of acute pulmonary embolism. (16931712)
2006
39
Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. (15163775)
2004
40
Intraoperative TEE for the management of pulmonary tumour embolism during chondroblastic osteosarcoma resection. (14617583)
2003
41
Correlation of thrombophilia and hypofibrinolysis with pulmonary embolism following total hip arthroplasty: an analysis of genetic factors. (12473703)
2002
42
Mechanical and enzymatic thrombolysis for massive pulmonary embolism. (11830622)
2002
43
Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism. (10385761)
1999
44
Atrial septal aneurysm plus a patent foramen ovale. A predisposing factor for paradoxical embolism and refractory hypoxemia during pulmonary embolism. (8797439)
1996
45
Thrombolytic therapy for treatment of pulmonary embolism in the postoperative period: case report and review of the literature. (8982898)
1996
46
Sudden onset of right bundle branch block. Acute pulmonary embolism. (8266162)
1993
47
Thrombolytic and pharmacokinetic properties of human tissue-type plasminogen activator variants, obtained by deletion and/or duplication of structural/functional domains, in a hamster pulmonary embolism model. (1905070)
1991
48
Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy. (6404103)
1983
49
Complications of ventriculo-atrial and peritoneal shunts. Report of a case with pulmonary embolisms and intestinal perforation. (5580063)
1971
50
Studies of experimental pulmonary embolism and infarction and the development of collateral circulation in the affected lung lobe. (13429204)
1957

Genetic Variations for Pulmonary Embolism

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Expression for genes affiliated with Pulmonary Embolism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, PLAT
210.3FGB, FGA, PLAT
3
Cell adhesion ECM remodeling
Hide members
10.3PLAT, FGA, FGB
4
Hide members
10.3FGB, FGA, F2
510.3FGB, FGA, F2
610.3F2, F10, F9
710.3MTHFR, CBS, F2, PLAT
8
Hide members
10.2F9, F10, F3, F2
9
Hide members
10.2FGB, FGA, F3, F2, SERPINF2
10
Hide members
10.2PF4, F13A1, F10, F5, F9
11
Hide members
10.1F5, F13A1, PF4, FGB, FGA, SERPINF2
12
Hide members
10.0F5, SERPINC1, F2, F3, FGA, FGB
13
Hide members
10.0F9, F5, F10, F13A1, FGB, FGA
14
Hide members
9.9FGA, FGB, F13A1, F10, F5, F9
15
Hide members
9.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA

Compounds for genes affiliated with Pulmonary Embolism

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1coumarins4410.6F9, F3, F10, APOH
2warfarin44 49 11 2413.6PF4, FGA, SERPINC1, APOH, F9
3spectrozyme4410.6PLAT, SERPINC1, F2, F3, F5, F10
4kaolin4410.6APOH, F5, F10, F3, F2, F9
5ptca4410.6APOH, NPPB, PF4, FGA, PLAT, SERPINF2
6dextran sulfate4410.6F9, APOH, F5, F10
7ancrod4410.6F5, F10, FGA, F2, PLAT, SERPINC1
8ristocetin4410.6F2, PLAT, SERPINC1, SERPINF2, F3, F5
9heparinoids4410.6F5, F10, F13A1, F3, F2, SERPINC1
10ecarin4410.5F5, F10, SERPINC1, F2, F3
11fibrinopeptide a4410.5PF4, FGA, F2, PLAT, SERPINC1, SERPINF2
12tirofiban44 1111.5NPPB, F10, PF4, F3, F2, PLAT
13batroxobin4410.5F2, F5, PLAT, FGB, FGA
14protamine sulfate4410.5F5, F10, PF4, F3, F2, PLAT
15ppack4410.5FGA, F10, F3, F2, SERPINC1, PLAT
16epsilon aminocaproic acid4410.5F2, SERPINC1, SERPINF2, F9, F3, PLAT
17gamma-carboxyglutamic acid4410.5F9, TNXA, F5, F10, PF4, F3
18ximelagatran44 1111.5F5, SERPINC1, F2, F3, F10
19organon4410.5F9, F10, F3, F2, SERPINC1
20argatroban44 1111.5F5, F10, FGA, F3, F2, SERPINC1
21serine4410.5CBS, F10, F9, FGA
22desmopressin44 59 28 1113.5SERPINF2, SERPINC1, PLAT, F2, F3, F5
23danaparoid4410.5TNXA, F5, F10, PF4, F3, F2
24coumarin44 2 49 2413.4F2, F10, F5, F9, F3, SERPINC1
25heparin44 28 11 2413.4F10, MTHFR, APOH, F9, F13A1, PF4
26bivalirudin44 1111.4SERPINC1, TNXA, F5, F10, FGA, F3
27ticlopidine44 1111.4F3, SERPINC1, PLAT, FGA, PF4, APOH
28homocysteine44 2411.4F9, APOH, NPPB, F5, MTHFR, CBS
29p0024410.4PLAT, FABP3, APOH, NPPB, PF4, MTHFR
30efegatran4410.4SERPINC1, F10, PLAT, F3
31abciximab44 1111.4PLAT, F10, PF4, SERPINC1, F3, F2
32fondaparinux4410.4TNXA, F5, F10, PF4, F3, F2
33tranexamic acid44 1111.4F2, SERPINC1, F9, F3, PLAT
34dermatan sulfate4410.4PLAT, SERPINC1, F2, F3, PF4, TNXA
3511-dehydrothromboxane b24410.3CBS, PF4, APOH, F2, FGA
36clopidogrel49 44 11 2413.3SERPINC1, F3, PLAT, F2, TNXA, F10
37protamine4410.3TNXA, F5, F10, PF4, FGA, F3
38desirudin4410.3F10, FGA, F3, PLAT
39kininogen4410.3F5, APOH, F9, F13A1, PF4, F3
40aprotinin44 1111.3SERPINC1, SERPINF2, F3, FGA, PLAT, F9
41citrate4410.3F10, F5, F9, F2, PF4, F3
42inogatran4410.3F2, F5, F3, SERPINC1
43prostacyclin4410.3APOH, NPPB, F5, PF4, PLAT, F3
44hirudin4410.2F9, TNXA, F5, F10, PF4, FGB
45thromboxane44 2411.1APOH, SERPINF2, CBS, PF4, FGA, PLAT
46aspirin44 49 28 2413.1SERPINC1, F3, FGA, PF4, F13A1, F10
47cacl24410.1F3, FGA, F10, F5, F9
48creatinine4410.1F3, FGA, PF4, MTHFR, F5, FABP3
49fibrinogen449.9PLAT, SERPINC1, F2, F3, F9, TNXA
50cholesterol44 28 11 2412.6MTHFR, CBS, FABP3, PF4, FGA, PLAT

GO Terms for genes affiliated with Pulmonary Embolism

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Sources:
16Gene Ontology
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Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4FGB, FGA, SERPINF2
2intrinsic to external side of plasma membraneGO:03123310.4F3, F10
3platelet alpha granuleGO:03109110.4FGA, FGB
4platelet alpha granule lumenGO:03109310.3SERPINF2, F5, F13A1, PF4, FGB, FGA
5troponin complexGO:00586110.2TNNI3, TNNC1
6cell surfaceGO:00998610.2APOH, FGB, FGA, F3, PLAT, SERPINF2
7extracellular spaceGO:00561510.1APOH, NPPB, F5, PF4, FGB, FGA
8Golgi lumenGO:00579610.0F2, F10, F9
9extracellular regionGO:00557610.0F13A1, F10, F5, NPPB, F9, PF4

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.5APOH, F2, SERPINF2
2blood coagulation, extrinsic pathwayGO:00759810.5F3, F10, F9
3blood coagulation, intrinsic pathwayGO:00759710.5F9, APOH, F10, F2
4fibrinolysisGO:04273010.5F2, PLAT, SERPINF2
5peptidyl-glutamic acid carboxylationGO:01718710.5F2, F10, F9
6platelet degranulationGO:00257610.4F5, F13A1, PF4, FGB, FGA, SERPINF2
7negative regulation of angiogenesisGO:01652510.4PF4, NPPB, APOH
8regulation of blood vessel sizeGO:05088010.4CBS, NPPB
9homocysteine metabolic processGO:05066710.4MTHFR, CBS
10platelet activationGO:03016810.3F5, F13A1, PF4, FGB, FGA, F2
11plasminogen activationGO:03163910.3APOH, PLAT
12positive regulation of blood coagulationGO:03019410.1F2, APOH
13blood coagulationGO:00759610.1SERPINF2, F9, F5, F10, F13A1, PF4

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.4TNNC1, TNNI3
2serine-type endopeptidase activityGO:00425210.4PLAT, F2, F10, F9
3modified amino acid bindingGO:07234110.4MTHFR, CBS
4receptor bindingGO:00510210.3F2, FGA, FGB, NPPB
5protease bindingGO:00202010.0F3, SERPINC1, SERPINF2
6protein bindingGO:0055159.6TNNI3, TNNC1, APOH, FABP3, F5, F10

Products for genes affiliated with Pulmonary Embolism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Embolism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet