MCID: PLM033
MIFTS: 64

Pulmonary Embolism malady

Cardiovascular diseases category

Summaries for Pulmonary Embolism

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35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Embolism, also known as pulmonary artery embolism, is related to venous thrombosis and hypertension. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs dicumarol and heparin and the compounds ancrod and fibrinopeptide a have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are muscle and integument.

CDC:4 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:66 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Related Diseases for Pulmonary Embolism

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18GeneCards, 19GeneDecks
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Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1venous thrombosis30.9FGB, F2, SERPINF2, F3, PLAT, F5
2hypertension30.9F5, PLAT, F2, NPPB
3thromboembolism30.8F2, SERPINF2, F3, PLAT, F5
4thrombocytopenia30.7F3, F2, F5
5protein s deficiency30.6F3, F5, F2
6antithrombin iii deficiency30.6F5, F2
7thrombophilia30.5SERPINF2, F2, F5, PLAT, F3
8hyperhomocysteinemia30.5F5, F2, PLAT
9protein c deficiency30.4F5, F2
10myocardial infarction30.4FABP3, SERPINF2, F3, PLAT, F5, NPPB
11sagittal sinus thrombosis30.3F5
12antiphospholipid syndrome30.3F5, PLAT, F3, F2
13disseminated intravascular coagulation30.3F5, F2, SERPINF2, F3, PLAT
14cardiogenic shock30.3NPPB, PLAT
15coronary thrombosis30.3F3, PLAT
16von willebrand's disease30.2F3, F2
17factor xi deficiency30.1F2, F5, F3
18afibrinogenemia30.1FGB
19portal vein thrombosis30.0F2, F5
20ischemia29.9NPPB, FABP3, PLAT
21coronary artery disease29.9NPPB, PLAT, F3
22factor vii deficiency29.9F5, F3, F2
23thrombocytosis29.9F2, SERPINF2, F3
24liver cirrhosis29.8SERPINF2, F3, F2
25acute myocardial infarction29.8SERPINF2, F3, PLAT, NPPB, FABP3
26factor v leiden thrombophilia29.8SERPINF2, F3, F5, PLAT, F2
27sepsis29.7NPPB, F5, F3, SERPINF2, F2
28pulmonary embolism and infarction10.8
29thrombophlebitis10.6
30patent foramen ovale10.6
31chronic thromboembolic pulmonary hypertension10.6
32cor pulmonale10.5
33heparin-induced thrombocytopenia10.5
34cerebritis10.5
35aneurysm10.4
36acute cor pulmonale10.4
37endocarditis10.4
38sarcoma10.4
39venous thromboembolism10.4
40pneumonia10.4
41right bundle branch block10.3
42syncope10.3
43klippel-trenaunay syndrome10.3
44puerperal pulmonary embolism10.3
45angiomyolipoma10.3
46hepatitis10.3
47leiomyomatosis10.3
48polycythemia10.3
49inferior vena cava interruption10.3
50membranous glomerulonephritis10.2

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Symptoms for Pulmonary Embolism

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Drugs & Therapeutics for Pulmonary Embolism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Pulmonary Embolism

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Anatomical Context for Pulmonary Embolism

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34MalaCards
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MalaCards organs/tissues related to Pulmonary Embolism:

34
Heart, Lung, Brain, Testes, Liver, Bone, Kidney, Colon, Pancreas, Thyroid, Breast, Ovary, Prostate, Spinal cord, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pulmonary Embolism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4FABP3, F3, PLAT, NPPB
2MP:00107718.2F5, F3, FABP3, F2
3MP:00053857.4NPPB, F5, PLAT, F3, FABP3, F2
4MP:00053767.2F2, SERPINF2, FABP3, F3, PLAT, F5

Publications for Pulmonary Embolism

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Sources:
53PubMed
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Articles related to Pulmonary Embolism:

(show top 50)    (show all 989)
idTitleAuthorsYear
1
Normal blood D-dimer concentrations: do they exclude pulmonary embolism? (24384418)
2014
2
Hospital costs of acute pulmonary embolism. (23331440)
2013
3
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
4
Pulmonary embolism hotline 2012. Recent and expected trials. (23337923)
2013
5
Catheter-directed intervention and thrombolysis for the treatment of massive pulmonary embolism that caused cardiac arrest. (24112187)
2013
6
The impact of saddle embolism on the major adverse event rate of patients with non-high-risk pulmonary embolism. (24058095)
2013
7
Prognostic value of the Charlson comorbidity index in pulmonary embolism. (23485768)
2013
8
A forgotten guidewire causing intracardiac multiple thrombi with paradoxical and pulmonary embolism. (23395220)
2013
9
Are vena cava filters effective in the treatment of pulmonary embolism? (24054953)
2013
10
Are all pulmonary embolism clinical decision rules equal? (23972135)
2013
11
Pulmonary embolism, part II: Management. (23940439)
2013
12
Validation of two clinical prognostic models in patients with acute symptomatic pulmonary embolism. (23664248)
2013
13
Volumetric reconstruction of the right ventricle improves reproducibility of interventricular septum bowing in patients with pulmonary embolism. (23740496)
2013
14
Plasma levels of mitochondrial and nuclear DNA in patients with massive pulmonary embolism in the emergency department: a prospective cohort study. (23705965)
2013
15
Point: should systemic lytic therapy be used for submassive pulmonary embolism? Yes. (23381309)
2013
16
Case fatality rate with vena cava filters in hospitalized stable patients with cancer and pulmonary embolism. (23968903)
2013
17
Subsegmental pulmonary embolism: is the emperor still naked? (23856806)
2013
18
Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia. (23429400)
2013
19
Congenital complete absence of pericardium masquerading as pulmonary embolism. (23580923)
2013
20
Fatal pulmonary embolism update: 10 years of autopsy experience at an academic medical center. (24040503)
2013
21
Benefits of texture analysis of dual energy CT for Computer-Aided pulmonary embolism detection. (24110602)
2013
22
Catheter-directed approaches to pulmonary embolism. (23498312)
2013
23
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
24
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
25
Hypereosinophilic syndrome presenting with large left ventricular apical thrombus and pulmonary embolism. (21854430)
2011
26
The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism. (21743331)
2011
27
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
28
Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk. (20691835)
2010
29
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
30
Postoperative pulmonary embolism in a three year old with Klippel-Trenaunay syndrome. (23754873)
2009
31
N-terminal pro-B-type natriuretic peptide predicts the burden of pulmonary embolism. (19214022)
2009
32
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
33
Persistent NT-proBNP elevation in acute pulmonary embolism predicts early death. (17507005)
2007
34
Brain natriuretic peptide in hemodynamically stable acute pulmonary embolism. (16405522)
2006
35
Biohumoral markers and right ventricular dysfunction in acute pulmonary embolism: the answer to thrombolytic therapy]. (15253142)
2004
36
Pulmonary Takayasu's arteritis masquerading as acute pulmonary embolism. (17039181)
2001
37
The role of lung scintigraphy in the diagnosis of nephrotic syndrome with pulmonary embolism. (10698409)
2000
38
Life threatening massive pulmonary embolism treated with reteplase: a case report. (16597314)
2000
39
Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit. (12086416)
1999
40
Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism. (10385761)
1999
41
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
42
Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis. (8562833)
1995
43
Acute pulmonary embolism. (8076500)
1994
44
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989
45
Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. (4013602)
1985
46
REFRACTORY DYSPNEA AND ORTHOPNEA; EVIDENCE OF RECURRENT PULMONARY EMBOLISM AND INFARCTION. (14340861)
1965
47
Pulmonary embolism and infarction. (13824271)
1960
48
Pulmonary embolism and infarction; a review of the physiologic consequences of pulmonary arterial obstruction. (13520740)
1958
49
Pulmonary embolism and infarction; diagnosis and management. (13238705)
1955
50
Pulmonary embolism with acute cor pulmonale and extremely rapid ventricular rate in a young, active apparently healthy adult. (15395458)
1949

Variations for Pulmonary Embolism

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Expression for genes affiliated with Pulmonary Embolism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 52PharmGKB, 54QIAGEN, 55R&D Systems, 31KEGG
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Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SERPINF2, PLAT
29.6PLAT, FGB
3
Show member pathways
thioredoxin pathway39
9.3PLAT, F2
4
Show member pathways
9.1F2, FGB
59.1FGB, F2
6
Show member pathways
9.0SERPINF2, FGB, F5
7
Show member pathways
8.1FGB, F5, F3, F2
8
Show member pathways
7.2PLAT, F2, FGB, F5, SERPINF2, F3
9
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.2F2, SERPINF2, PLAT, F3, FGB, F5
10
Show member pathways
7.2SERPINF2, F3, PLAT, F5, FGB, F2

Compounds for genes affiliated with Pulmonary Embolism

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1ancrod469.2F5, PLAT, F2
2fibrinopeptide a469.1SERPINF2, PLAT, F2
3p002469.1PLAT, F5, NPPB, FABP3
4heparin sodium469.1F2, F3, PLAT
5dextran 70469.1PLAT, F3, F2
6mnpt469.0F3, F2
7ptca469.0PLAT, NPPB, F3, SERPINF2
8inogatran469.0F5, F3, F2
9ecarin469.0F5, F3, F2
10ppack469.0PLAT, F2, F3
11tranexamic acid46 129.9PLAT, F2, F3
12danaparoid468.9F3, F2, F5
13kaolin468.9F5, F3, F2
14ximelagatran46 129.9F5, F2, F3
15heparinoids468.9F2, F3, F5
16acenocoumarol46 52 1210.9F2, F5, F3
17coumarins468.9F2, F5, F3
18nitroglycerin46 129.8F3, PLAT, NPPB
19abciximab46 129.8PLAT, F3, F2
20prostacyclin468.8F5, NPPB, PLAT, F3
21batroxobin468.8F2, PLAT, FGB, F5
22gamma-carboxyglutamic acid468.8F5, F3, F2
23tirofiban46 129.7F2, NPPB, PLAT, F3
24clopidogrel46 52 25 1211.7F2, PLAT, F3
25spectrozyme468.7PLAT, F3, F2, F5
26fondaparinux468.7F2, F3, PLAT, F5
27bivalirudin46 129.7F3, PLAT, F2, F5
28argatroban46 129.7F2, F5, PLAT, F3
29protamine sulfate468.7PLAT, F5, F3, F2
30coumarin46 3 52 2511.6F2, F3, F5
31levonorgestrel46 62 30 1211.6F2, F3, F5, PLAT
32protamine468.6PLAT, F3, F2, F5
33dermatan sulfate468.6PLAT, F3, F2, F5
34epsilon aminocaproic acid468.6PLAT, SERPINF2, F2, F3
35warfarin46 52 25 1211.6F5, F2, PLAT, F3
36cardiolipin46 129.5F5, F3, F2
37simvastatin46 52 62 30 25 1213.4PLAT, F2, F5, F3
38citrate468.4F2, FABP3, F5, F3
39homocysteine46 259.2F2, NPPB, F5, PLAT, F3
40aspirin46 52 30 2511.2F2, NPPB, F3, PLAT, F5
41ristocetin468.2F3, PLAT, SERPINF2, F5, F2
42desmopressin46 62 30 1211.2F2, PLAT, F3, SERPINF2, F5
43kininogen468.1SERPINF2, F2, F5, PLAT, F3
44epinephrine46 25 1210.0SERPINF2, F3, NPPB, F2, F5
45creatinine467.8F3, F2, FABP3, PLAT, F5, NPPB
46aprotinin46 128.7SERPINF2, NPPB, F5, PLAT, F3, F2
47hirudin467.6FGB, SERPINF2, F3, PLAT, F5, F2
48fibrinogen467.6FGB, SERPINF2, F3, PLAT, F2, F5
49heparin46 30 25 1210.2NPPB, F5, PLAT, F3, SERPINF2, F2
50serine467.1PLAT, SERPINF2, F2, NPPB, FGB, F3

GO Terms for genes affiliated with Pulmonary Embolism

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17Gene Ontology
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Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.1SERPINF2, FGB
2platelet alpha granule lumenGO:0310939.0F5, FGB, SERPINF2
3blood microparticleGO:0725628.6FGB, SERPINF2, F2
4cell surfaceGO:0099868.4FGB, F3, SERPINF2, PLAT
5extracellular regionGO:0055767.5FGB, NPPB, F2, SERPINF2, PLAT, F5
6extracellular spaceGO:0056156.9F3, F2, SERPINF2, PLAT, F5, NPPB

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:0458619.2PLAT, F2
2negative regulation of fibrinolysisGO:0519189.1SERPINF2, F2
3acute-phase responseGO:0069539.1SERPINF2, F2
4platelet degranulationGO:0025769.0FGB, F5, SERPINF2
5fibrinolysisGO:0427308.9PLAT, SERPINF2, F2
6positive regulation of collagen biosynthetic processGO:0329678.8F2, SERPINF2
7platelet activationGO:0301688.3FGB, F5, F2, SERPINF2
8blood coagulationGO:0075967.4F5, F3, PLAT, F2, FGB, SERPINF2

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3SERPINF2, F3
2serine-type endopeptidase activityGO:0042528.9F5, PLAT, F2
3receptor bindingGO:0051028.4F2, NPPB, FGB
4protein bindingGO:0055156.7F2, FGB, PLAT, F3, FABP3, SERPINF2

Products for genes affiliated with Pulmonary Embolism

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  • Antibodies
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Sources for Pulmonary Embolism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet