MCID: PLM033
MIFTS: 66

Pulmonary Embolism malady

Cardiovascular diseases category

Summaries for Pulmonary Embolism

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MedlinePlus:34 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards based summary: Pulmonary Embolism, also known as pulmonary artery embolism, is related to myocardial infarction and thrombocytopenia. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs heparin and heparin sodium and the compounds ancrod and fibrinopeptide a have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are muscle and integument.

Disease Ontology:10 An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot.

CDC:4 Learn how to prevent DVT, a serious blood clot that can cause illness, disability, and even, death.

Wikipedia:65 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 34MedlinePlus, 4CDC, 62UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD10
See all sources

Pulmonary Embolism, Aliases & Descriptions:

Name: Pulmonary Embolism 10 12 45 34 4 62
Pulmonary Artery Embolism 10 62
 
Pulmonary Embolus 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:9477
NCIt40 C50713
MeSH35 D011655
ICD1027 I26, I26.0, I26.9

Related Diseases for Pulmonary Embolism

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Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction30.7FABP3, SERPINF2, F3, PLAT, F5, NPPB
2thrombocytopenia30.7F3, F2, F5
3protein s deficiency30.7F3, F5, F2
4thrombophilia30.6SERPINF2, F2, F5, PLAT, F3
5protein c deficiency30.5F5, F2
6hyperhomocysteinemia30.5F5, F2, PLAT
7atrial fibrillation30.4F2, NPPB, PLAT
8disseminated intravascular coagulation30.4F5, F2, SERPINF2, F3, PLAT
9antiphospholipid syndrome30.4F5, PLAT, F3, F2
10sagittal sinus thrombosis30.3F5
11cardiogenic shock30.2NPPB, PLAT
12coronary thrombosis30.2F3, PLAT
13von willebrand's disease30.2F3, F2
14thrombocytosis30.1F2, SERPINF2, F3
15thrombophilia due to thrombin defect30.1F2, SERPINF2, F3, PLAT, F5
16portal vein thrombosis30.0F2, F5
17thrombophilia due to antithrombin iii deficiency30.0F5, F2
18ischemia30.0NPPB, FABP3, PLAT
19coronary artery disease29.9NPPB, PLAT, F3
20factor vii deficiency29.9F5, F3, F2
21hemophilia a29.9F5, F2, F3
22liver cirrhosis29.9SERPINF2, F3, F2
23acute myocardial infarction29.9SERPINF2, F3, PLAT, NPPB, FABP3
24afibrinogenemia29.9FGB, F2, F3, F5
25factor v leiden thrombophilia29.9SERPINF2, F3, F5, PLAT, F2
26pulmonary embolism and infarction10.8
27pulmonary hypertension10.7
28patent foramen ovale10.6
29thrombophlebitis10.6
30chronic thromboembolic pulmonary hypertension10.6
31cor pulmonale10.6
32heparin-induced thrombocytopenia10.5
33cerebritis10.5
34aneurysm10.5
35pneumonia10.4
36sarcoma10.4
37acute cor pulmonale10.4
38endocarditis10.4
39inferior myocardial infarction10.4
40syncope10.4
41hepatitis10.3
42right bundle branch block10.3
43puerperal pulmonary embolism10.3
44adenocarcinoma10.3
45angiomyolipoma10.3
46leiomyomatosis10.3
47polycythemia10.3
48inferior vena cava interruption10.3
49klippel-trenaunay-weber syndrome10.2
50polycythemia vera10.2

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Symptoms for Pulmonary Embolism

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Drugs & Therapeutics for Pulmonary Embolism

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Genetic Tests for Pulmonary Embolism

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Anatomical Context for Pulmonary Embolism

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MalaCards organs/tissues related to Pulmonary Embolism:

33
Lung, Heart, Brain, Testes, Liver, Bone, Neutrophil, Spinal cord, Colon, Kidney, Pancreas, Thyroid, Breast, Ovary, Prostate, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Embolism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4FABP3, F3, PLAT, NPPB
2MP:00107718.2F5, F3, FABP3, F2
3MP:00053857.4NPPB, F5, PLAT, F3, FABP3, F2
4MP:00053767.2F2, SERPINF2, FABP3, F3, PLAT, F5

Publications for Pulmonary Embolism

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Articles related to Pulmonary Embolism:

(show top 50)    (show all 1054)
idTitleAuthorsYear
1
Once daily versus twice daily enoxaparin for acute pulmonary embolism in cancer patients. (25888639)
2015
2
Normal blood D-dimer concentrations: do they exclude pulmonary embolism? (24384418)
2014
3
ECG manifestations in submassive and massive pulmonary embolism. Report of 4 cases and review of literature. (23890684)
2014
4
Hospital costs of acute pulmonary embolism. (23331440)
2013
5
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
6
Pulmonary embolism hotline 2012. Recent and expected trials. (23337923)
2013
7
Catheter-directed intervention and thrombolysis for the treatment of massive pulmonary embolism that caused cardiac arrest. (24112187)
2013
8
The impact of saddle embolism on the major adverse event rate of patients with non-high-risk pulmonary embolism. (24058095)
2013
9
Prognostic value of the Charlson comorbidity index in pulmonary embolism. (23485768)
2013
10
A forgotten guidewire causing intracardiac multiple thrombi with paradoxical and pulmonary embolism. (23395220)
2013
11
Are vena cava filters effective in the treatment of pulmonary embolism? (24054953)
2013
12
Are all pulmonary embolism clinical decision rules equal? (23972135)
2013
13
Pulmonary embolism, part II: Management. (23940439)
2013
14
Validation of two clinical prognostic models in patients with acute symptomatic pulmonary embolism. (23664248)
2013
15
Volumetric reconstruction of the right ventricle improves reproducibility of interventricular septum bowing in patients with pulmonary embolism. (23740496)
2013
16
Plasma levels of mitochondrial and nuclear DNA in patients with massive pulmonary embolism in the emergency department: a prospective cohort study. (23705965)
2013
17
Importance of history in the diagnosis of pulmonary embolism. (23512456)
2013
18
Case fatality rate with vena cava filters in hospitalized stable patients with cancer and pulmonary embolism. (23968903)
2013
19
Subsegmental pulmonary embolism: is the emperor still naked? (23856806)
2013
20
Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia. (23429400)
2013
21
Congenital complete absence of pericardium masquerading as pulmonary embolism. (23580923)
2013
22
Fatal pulmonary embolism update: 10 years of autopsy experience at an academic medical center. (24040503)
2013
23
Benefits of texture analysis of dual energy CT for Computer-Aided pulmonary embolism detection. (24110602)
2013
24
Catheter-directed approaches to pulmonary embolism. (23498312)
2013
25
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
26
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
27
Hypereosinophilic syndrome presenting with large left ventricular apical thrombus and pulmonary embolism. (21854430)
2011
28
The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism. (21743331)
2011
29
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
30
Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk. (20691835)
2010
31
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
32
Postoperative pulmonary embolism in a three year old with Klippel-Trenaunay syndrome. (23754873)
2009
33
N-terminal pro-B-type natriuretic peptide predicts the burden of pulmonary embolism. (19214022)
2009
34
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
35
Persistent NT-proBNP elevation in acute pulmonary embolism predicts early death. (17507005)
2007
36
Brain natriuretic peptide in hemodynamically stable acute pulmonary embolism. (16405522)
2006
37
Biohumoral markers and right ventricular dysfunction in acute pulmonary embolism: the answer to thrombolytic therapy]. (15253142)
2004
38
Pulmonary Takayasu's arteritis masquerading as acute pulmonary embolism. (17039181)
2001
39
The role of lung scintigraphy in the diagnosis of nephrotic syndrome with pulmonary embolism. (10698409)
2000
40
Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit. (12086416)
1999
41
Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism. (10385761)
1999
42
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
43
Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis. (8562833)
1995
44
Acute pulmonary embolism. (8076500)
1994
45
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989
46
Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. (4013602)
1985
47
REFRACTORY DYSPNEA AND ORTHOPNEA; EVIDENCE OF RECURRENT PULMONARY EMBOLISM AND INFARCTION. (14340861)
1965
48
Pulmonary embolism and infarction. (13824271)
1960
49
Pulmonary embolism and infarction; diagnosis and management. (13238705)
1955
50
Pulmonary embolism with acute cor pulmonale and extremely rapid ventricular rate in a young, active apparently healthy adult. (15395458)
1949

Variations for Pulmonary Embolism

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Expression for genes affiliated with Pulmonary Embolism

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Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

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Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SERPINF2, PLAT
29.6PLAT, FGB
3
Show member pathways
thioredoxin pathway38
9.3PLAT, F2
4
Show member pathways
9.1F2, FGB
59.1FGB, F2
6
Show member pathways
9.0SERPINF2, FGB, F5
7
Show member pathways
8.1FGB, F5, F3, F2
8
Show member pathways
7.2PLAT, F2, FGB, F5, SERPINF2, F3
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
7.2F2, SERPINF2, PLAT, F3, FGB, F5
10
Show member pathways
7.2SERPINF2, F3, PLAT, F5, FGB, F2

Compounds for genes affiliated with Pulmonary Embolism

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Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1ancrod459.2F5, PLAT, F2
2fibrinopeptide a459.1SERPINF2, PLAT, F2
3p002459.1PLAT, F5, NPPB, FABP3
4heparin sodium459.1F2, F3, PLAT
5dextran 70459.1PLAT, F3, F2
6aprosulate459.0F3, F2
7ptca459.0PLAT, NPPB, F3, SERPINF2
8inogatran459.0F5, F3, F2
9ecarin459.0F5, F3, F2
10ppack459.0PLAT, F2, F3
11tranexamic acid45 139.9PLAT, F2, F3
12danaparoid458.9F3, F2, F5
13kaolin458.9F5, F3, F2
14ximelagatran45 139.9F5, F2, F3
15heparinoids458.9F2, F3, F5
16acenocoumarol45 51 1310.9F2, F5, F3
17coumarins458.9F2, F5, F3
18nitroglycerin45 139.8F3, PLAT, NPPB
19abciximab45 139.8PLAT, F3, F2
20prostacyclin458.8F5, NPPB, PLAT, F3
21batroxobin458.8F2, PLAT, FGB, F5
22gamma-carboxyglutamic acid458.8F5, F3, F2
23tirofiban45 139.7F2, NPPB, PLAT, F3
24clopidogrel45 51 26 1311.7F2, PLAT, F3
25spectrozyme458.7PLAT, F3, F2, F5
26fondaparinux458.7F2, F3, PLAT, F5
27bivalirudin45 139.7F3, PLAT, F2, F5
28argatroban45 139.7F2, F5, PLAT, F3
29protamine sulfate458.7PLAT, F5, F3, F2
30coumarin45 3 51 2611.6F2, F3, F5
31levonorgestrel45 61 30 1311.6F2, F3, F5, PLAT
32protamine458.6PLAT, F3, F2, F5
33dermatan sulfate458.6PLAT, F3, F2, F5
34epsilon aminocaproic acid458.6PLAT, SERPINF2, F2, F3
35warfarin45 51 26 1311.6F5, F2, PLAT, F3
36cardiolipin45 139.5F5, F3, F2
37simvastatin45 51 61 30 26 1313.4PLAT, F2, F5, F3
38citrate458.4F2, FABP3, F5, F3
39homocysteine45 269.2F2, NPPB, F5, PLAT, F3
40aspirin45 51 30 2611.2F2, NPPB, F3, PLAT, F5
41ristocetin458.2F3, PLAT, SERPINF2, F5, F2
42desmopressin45 61 30 1311.2F2, PLAT, F3, SERPINF2, F5
43kininogen458.1SERPINF2, F2, F5, PLAT, F3
44epinephrine45 26 1310.0SERPINF2, F3, NPPB, F2, F5
45creatinine457.8F3, F2, FABP3, PLAT, F5, NPPB
46aprotinin45 138.7SERPINF2, NPPB, F5, PLAT, F3, F2
47hirudin457.6FGB, SERPINF2, F3, PLAT, F5, F2
48fibrinogen457.6FGB, SERPINF2, F3, PLAT, F2, F5
49heparin45 30 26 1310.2NPPB, F5, PLAT, F3, SERPINF2, F2
50serine457.1PLAT, SERPINF2, F2, NPPB, FGB, F3

GO Terms for genes affiliated with Pulmonary Embolism

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Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00055779.1SERPINF2, FGB
2platelet alpha granule lumenGO:00310939.0F5, FGB, SERPINF2
3blood microparticleGO:00725628.6FGB, SERPINF2, F2
4cell surfaceGO:00099868.4FGB, F3, SERPINF2, PLAT
5extracellular regionGO:00055767.5FGB, NPPB, F2, SERPINF2, PLAT, F5
6extracellular spaceGO:00056156.9F3, F2, SERPINF2, PLAT, F5, NPPB

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:00458619.2PLAT, F2
2negative regulation of fibrinolysisGO:00519189.1SERPINF2, F2
3acute-phase responseGO:00069539.1SERPINF2, F2
4platelet degranulationGO:00025769.0FGB, F5, SERPINF2
5fibrinolysisGO:00427308.9PLAT, SERPINF2, F2
6positive regulation of collagen biosynthetic processGO:00329678.8F2, SERPINF2
7platelet activationGO:00301688.3FGB, F5, F2, SERPINF2
8blood coagulationGO:00075967.4F5, F3, PLAT, F2, FGB, SERPINF2

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.3SERPINF2, F3
2serine-type endopeptidase activityGO:00042528.9F5, PLAT, F2
3receptor bindingGO:00051028.4F2, NPPB, FGB
4protein bindingGO:00055156.7F2, FGB, PLAT, F3, FABP3, SERPINF2

Products for genes affiliated with Pulmonary Embolism

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Sources for Pulmonary Embolism

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet