MCID: PLM033
MIFTS: 60

Pulmonary Embolism malady

Cardiovascular category

Summaries for Pulmonary Embolism

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Embolism, also known as pulmonary artery embolism, is related to venous thrombosis and thrombophlebitis. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion ECM remodeling. The drugs dicumarol and heparin and the compounds coumarins and warfarin have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and reproductive system.

CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:64 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Related Diseases for Pulmonary Embolism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1venous thrombosis31.2SERPINF2, SERPINC1, PLAT, F2, F3, FGA
2thrombophlebitis30.9APOH
3patent foramen ovale30.9F5
4thrombocytopenia30.7SERPINC1, F2, F3, FGA, PF4, F10
5thrombophilia30.6SERPINF2, SERPINC1, PLAT, F2, F3, FGA
6protein c deficiency30.6SERPINC1, F2, MTHFR, F5, APOH, F9
7thromboembolism30.5SERPINF2, SERPINC1, PLAT, F2, F3, FGA
8stroke, ischemic30.5F2, F5
9polycythemia vera30.4PF4
10hyperhomocysteinemia30.4SERPINC1, PLAT, F2, CBS, MTHFR, F5
11protein s deficiency30.4SERPINC1, F5, F9
12antiphospholipid syndrome30.4SERPINC1, PLAT, F2, F3, PF4, F10
13adenocarcinoma30.3PF4, F13A1, TNXA
14arthritis30.1F10
15sagittal sinus thrombosis30.1SERPINC1, F5
16coronary thrombosis30.1SERPINC1, PLAT, F3
17cardiogenic shock30.1PLAT, NPPB
18hepatitis a29.9F2
19hepatitis c29.9F2, F9
20factor v deficiency29.9F2, F3, F5
21deficiency anemia29.9F2, F3, F9
22portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5
23acute leukemia29.9FGA, MTHFR
24prothrombin deficiency29.9SERPINC1, F2, F5, APOH
25afibrinogenemia29.9FGA, FGB
26marfan syndrome29.9CBS, F9
27cardiac rupture29.9PLAT
28thrombocytosis29.9SERPINF2, SERPINC1, F2, F3, FGA, PF4
29hypertrophic cardiomyopathy29.9TNNI3
30sepsis29.9SERPINF2, SERPINC1, F2, F3, FGA, F10
31coronary artery disease,29.9PLAT, F3, FGA, PF4, CBS, F10
32nephritis29.9APOH
33acute myocardial infarction29.9SERPINF2, SERPINC1, PLAT, F3, FGA, PF4
34factor v leiden thrombophilia29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
35chronic thromboembolic pulmonary hypertension10.6
36pulmonary function10.5
37heparin-induced thrombocytopenia10.5
38n syndrome10.5
39mass syndrome10.4
40klippel-trenaunay syndrome10.3
41protein r deficiency10.3
42venous thromboembolism10.3
43puerperal pulmonary embolism10.3
44syncope10.3
45inferior vena cava interruption10.3
46angiomyolipoma10.3
47membranous glomerulonephritis10.2
48lemierre's syndrome10.2
49arteriovenous malformation10.2
50peripartum cardiomyopathy10.2

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Clinical Features for Pulmonary Embolism

Drugs & Therapeutics for Pulmonary Embolism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Pulmonary Embolism

Anatomical Context for Pulmonary Embolism

Animal Models for Pulmonary Embolism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pulmonary Embolism

Sources:
51PubMed
See all sources

Articles related to Pulmonary Embolism:

(show top 50)    (show all 1035)
idTitleAuthorsYear
1
Right ventricular dilatation on bedside echocardiography performed by emergency physicians AIDS in the diagnosis of pulmonary embolism. (24075286)
2014
2
Computed tomography and echocardiography in patients with acute pulmonary embolism: part 2: prognostic value. (24157622)
2014
3
Are vena cava filters effective in the treatment of pulmonary embolism? (24054953)
2013
4
Detection of acute pulmonary embolism: feasibility of diagnostic accuracy of MRI using a stepwise protocol. (24282047)
2013
5
Thrombolysis in patients with pulmonary embolism and elevated heart-type fatty acid-binding protein levels. (24264959)
2013
6
Can isolated ST elevation in aVR lead be a sign of acute pulmonary embolism? (23443863)
2013
7
Clinical impact of findings supporting an alternative diagnosis on CT pulmonary angiography in patients with suspected pulmonary embolism. (23989896)
2013
8
Perfusion SPECT in patients with suspected pulmonary embolism: how much sensitivity is needed to keep patients alive? (23748237)
2013
9
Are Bilateral Total Joint Arthroplasty Patients at a Higher Risk of Developing Pulmonary Embolism Following Total Hip and Knee Surgery? (24360492)
2013
10
CASE REPORT Acute Compartment Syndrome of the Forearm Following Blood Gas Analysis Postthrombolysis for Pulmonary Embolism. (23573335)
2013
11
Retrograde systemic to pulmonary shunt simulating a pulmonary embolism. (23352877)
2013
12
Heightened clinical suspicion of pulmonary embolism and disregard of the D-dimer assay: a contemporary trend in an era of increased access to computed tomography pulmonary angiogram? (23800111)
2013
13
Cannonball shadow in the lungs and pulmonary embolism in a young man. (23853007)
2013
14
Tricuspid valve endocarditis complicated by septic pulmonary embolism in an intravenous drug user. (24078456)
2013
15
Deep venous thrombosis and pulmonary embolism. Part 1. Initial treatment: usually a low-molecular-weight heparin. (23662321)
2013
16
Therapeutic dilemma in unstable pulmonary embolism. (24157301)
2013
17
Pulmonary artery tumor embolism in a patient with previous fibroblastic osteosarcoma. (23706436)
2013
18
Transcatheter treatment for pulmonary artery occlusion secondary to pulmonary embolism in an infant. (23902997)
2013
19
Pulmonary artery sarcoma masquerading as pulmonary embolism. (24180442)
2013
20
JAMA patient page. Pulmonary embolism. (23385279)
2013
21
Planar images reprojected from SPECT V/Q data perform similarly to traditional planar V/Q scans in the diagnosis of pulmonary embolism. (23442545)
2013
22
Long-term clinical course of acute pulmonary embolism. (23791363)
2013
23
Pulmonary embolism related to amisulpride treatment: a case report. (23533901)
2013
24
Clinical utility of ultra high pitch dual source thoracic CT imaging of acute pulmonary embolism in the emergency department: are we one step closer towards a non-gated triple rule out? (23743054)
2013
25
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
26
Pulmonary embolism in echinococcosis: two case reports and literature review. (21294952)
2011
27
Pulmonary-vein stenosis can mimic massive pulmonary embolism after radiofrequency ablation for atrial fibrillation. (21333083)
2011
28
Surgical thromboembolectomy for a massive pulmonary embolism after several venous thromboembolic episodes caused by congenital antithrombin III deficiency. (22051999)
2011
29
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
30
Acute pulmonary embolism and a patent foramen ovale: analysis of atrial right-to-left shunting by biphasic transcardiopulmonary thermodilution curves. (20650385)
2010
31
Brain natriuretic peptide as a preclinical marker of chronic pulmonary hypertension in patients with pulmonary embolism. (19247590)
2009
32
Cardiac biomarkers for risk stratification in non-massive pulmonary embolism: a multicenter prospective study. (19087222)
2009
33
Pulmonary artery sarcoma mimicking a pulmonary embolism. (18453737)
2008
34
The efficacy of alteplase in pulmonary embolism treatment]. (18833155)
2008
35
Cyanoacrylate-related pulmonary embolism following percutaneous varicocele embolization. (18791515)
2008
36
Combined utility of brain natriuretic peptide and cardiac troponin T may improve rapid triage and risk stratification in normotensive patients with pulmonary embolism. (16814410)
2007
37
Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department. (16574759)
2006
38
Update in the prevention and treatment of deep vein thrombosis and pulmonary embolism. (16547433)
2006
39
Instructive ECG series in massive bilateral pulmonary embolism. (15958344)
2005
40
Laparoscopic procedures as a risk factor of deep venous thrombosis, superficial ascending thrombophlebitis and pulmonary embolism--case report and review of the literature. (15546806)
2004
41
Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty. (24383778)
2001
42
Low-molecular-weight heparins versus unfractionated heparin in the treatment of deep vein thrombosis and pulmonary embolism. (10994898)
2000
43
Clinical outcome of catheter fragmentation and aspiration therapy in patients with acute pulmonary embolism]. (10466088)
1999
44
Protein-losing enteropathy and massive pulmonary embolism in a patient with giant inflammatory polyposis and quiescent ulcerative colitis. (8873495)
1996
45
Thrombophlebitis and pulmonary embolism in the elderly patient. (8222567)
1993
46
Fatal pulmonary bile embolism following acute acalculous cholecystitis. (3767652)
1986
47
Right atrial septal aneurysm: an unusual cause of recurrent pulmonary embolism. (3996007)
1985
48
PULMONARY EMBOLISM AND INFARCTION. (14276783)
1965
49
Coronary thrombosis, cerebral vascular accident and pulmonary embolism in leprosy. (13742762)
1960
50
Gross arterial embolism by a myxosarcoma of pulmonary origin. (13212573)
1954

Genetic Variations for Pulmonary Embolism

Expression for genes affiliated with Pulmonary Embolism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

Sources:
54Reactome, 12EMD Millipore, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 30KEGG
See all sources

Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PLAT, SERPINF2
2
Cell adhesion ECM remodeling
Hide members
10.3FGA, FGB, PLAT
310.3FGB, PLAT, FGA
4
Hide members
10.3FGB, F2, FGA
510.3FGA, FGB, F2
610.3F10, F2, F9
710.3PLAT, CBS, F2, MTHFR
8
Hide members
10.2F10, F3, F2, F9
9
Hide members
10.2F3, F2, FGA, SERPINF2, FGB
10
Hide members
10.2PF4, F5, F10, F13A1, F9
11
Hide members
10.1F13A1, PF4, FGA, F5, SERPINF2, FGB
12
Hide members
10.0F5, F10, F13A1, FGB, FGA, F2
13
Hide members
10.0F5, F9, F10, F13A1, FGB, FGA
14
Hide members
9.9SERPINC1, SERPINF2, PLAT, F2, F3, F9
15
Hide members
9.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA

Compounds for genes affiliated with Pulmonary Embolism

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1coumarins4510.6F9, F3, F10, APOH
2warfarin45 50 11 2413.6PF4, FGA, SERPINC1, APOH, F9
3spectrozyme4510.6PLAT, SERPINC1, F2, F3, F5, F10
4kaolin4510.6APOH, F5, F10, F3, F2, F9
5ptca4510.6APOH, NPPB, PF4, FGA, PLAT, SERPINF2
6dextran sulfate4510.6F9, APOH, F5, F10
7ancrod4510.6F5, F10, FGA, F2, PLAT, SERPINC1
8ristocetin4510.6F2, PLAT, SERPINC1, SERPINF2, F3, F5
9heparinoids4510.6F5, F10, F13A1, F3, F2, SERPINC1
10ecarin4510.5F5, F10, SERPINC1, F2, F3
11fibrinopeptide a4510.5PF4, FGA, F2, PLAT, SERPINC1, SERPINF2
12tirofiban45 1111.5NPPB, F10, PF4, F3, F2, PLAT
13batroxobin4510.5F2, F5, PLAT, FGB, FGA
14protamine sulfate4510.5F5, F10, PF4, F3, F2, PLAT
15ppack4510.5FGA, F10, F3, F2, SERPINC1, PLAT
16epsilon aminocaproic acid4510.5F2, SERPINC1, SERPINF2, F9, F3, PLAT
17gamma-carboxyglutamic acid4510.5F9, TNXA, F5, F10, PF4, F3
18ximelagatran45 1111.5F5, SERPINC1, F2, F3, F10
19organon4510.5F9, F10, F3, F2, SERPINC1
20argatroban45 1111.5F5, F10, FGA, F3, F2, SERPINC1
21serine4510.5CBS, F10, F9, FGA
22desmopressin45 60 29 1113.5SERPINF2, SERPINC1, PLAT, F2, F3, F5
23danaparoid4510.5TNXA, F5, F10, PF4, F3, F2
24coumarin45 2 50 2413.4F2, F10, F5, F9, F3, SERPINC1
25heparin45 29 11 2413.4F10, MTHFR, APOH, F9, F13A1, PF4
26bivalirudin45 1111.4SERPINC1, TNXA, F5, F10, FGA, F3
27ticlopidine45 1111.4F3, SERPINC1, PLAT, FGA, PF4, APOH
28homocysteine45 2411.4F9, APOH, NPPB, F5, MTHFR, CBS
29p0024510.4PLAT, FABP3, APOH, NPPB, PF4, MTHFR
30efegatran4510.4SERPINC1, F10, PLAT, F3
31abciximab45 1111.4PLAT, F10, PF4, SERPINC1, F3, F2
32fondaparinux4510.4TNXA, F5, F10, PF4, F3, F2
33tranexamic acid45 1111.4F2, SERPINC1, F9, F3, PLAT
34dermatan sulfate4510.4PLAT, SERPINC1, F2, F3, PF4, TNXA
3511-dehydrothromboxane b24510.3CBS, PF4, APOH, F2, FGA
36clopidogrel50 45 11 2413.3SERPINC1, F3, PLAT, F2, TNXA, F10
37protamine4510.3TNXA, F5, F10, PF4, FGA, F3
38desirudin4510.3F10, FGA, F3, PLAT
39kininogen4510.3F5, APOH, F9, F13A1, PF4, F3
40aprotinin45 1111.3SERPINC1, SERPINF2, F3, FGA, PLAT, F9
41citrate4510.3F10, F5, F9, F2, PF4, F3
42inogatran4510.3F2, F5, F3, SERPINC1
43prostacyclin4510.3APOH, NPPB, F5, PF4, PLAT, F3
44hirudin4510.2F9, TNXA, F5, F10, PF4, FGB
45thromboxane45 2411.1APOH, SERPINF2, CBS, PF4, FGA, PLAT
46aspirin45 50 29 2413.1SERPINC1, F3, FGA, PF4, F13A1, F10
47cacl24510.1F3, FGA, F10, F5, F9
48creatinine4510.1F3, FGA, PF4, MTHFR, F5, FABP3
49fibrinogen459.9PLAT, SERPINC1, F2, F3, F9, TNXA
50cholesterol45 29 11 2412.6MTHFR, CBS, FABP3, PF4, FGA, PLAT

GO Terms for genes affiliated with Pulmonary Embolism

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4FGB, SERPINF2, FGA
2intrinsic to external side of plasma membraneGO:03123310.4F3, F10
3platelet alpha granule lumenGO:03109310.3F5, F13A1, PF4, FGA, SERPINF2, FGB
4Golgi lumenGO:00579610.3F9, F10, F2
5troponin complexGO:00586110.2TNNI3, TNNC1
6cell surfaceGO:00998610.2APOH, FGB, FGA, F3, PLAT, SERPINF2
7extracellular spaceGO:00561510.1F3, F2, SERPINF2, SERPINC1, FGA, FGB
8platelet alpha granuleGO:03109110.1FGB, FGA
9extracellular regionGO:00557610.0FGB, SERPINF2, SERPINC1, F2, F13A1, F10

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.5APOH, F2, SERPINF2
2blood coagulation, extrinsic pathwayGO:00759810.5F3, F10, F9
3blood coagulation, intrinsic pathwayGO:00759710.5F9, APOH, F10, F2
4fibrinolysisGO:04273010.5F2, PLAT, SERPINF2
5peptidyl-glutamic acid carboxylationGO:01718710.5F2, F10, F9
6platelet degranulationGO:00257610.4F5, F13A1, PF4, FGB, FGA, SERPINF2
7negative regulation of angiogenesisGO:01652510.4PF4, NPPB, APOH
8regulation of blood vessel sizeGO:05088010.4CBS, NPPB
9homocysteine metabolic processGO:05066710.4MTHFR, CBS
10platelet activationGO:03016810.3F5, F13A1, PF4, FGB, FGA, F2
11plasminogen activationGO:03163910.3APOH, PLAT
12positive regulation of blood coagulationGO:03019410.1F2, APOH
13blood coagulationGO:00759610.1SERPINF2, F9, F5, F10, F13A1, PF4

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.4TNNC1, TNNI3
2serine-type endopeptidase activityGO:00425210.4PLAT, F2, F10, F9
3modified amino acid bindingGO:07234110.4MTHFR, CBS
4receptor bindingGO:00510210.3F2, FGA, FGB, NPPB
5protease bindingGO:00202010.0F3, SERPINC1, SERPINF2
6protein bindingGO:0055159.6TNNI3, TNNC1, APOH, FABP3, F5, F10

Products for genes affiliated with Pulmonary Embolism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Embolism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet