MCID: PLM033
MIFTS: 68

Pulmonary Embolism malady

Cardiovascular diseases category

Summaries for Pulmonary Embolism

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Embolism, also known as pulmonary artery embolism, is related to hypertension and thrombophlebitis. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs heparin and heparin sodium and the compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are vision/eye and reproductive system.

CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:63 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Pulmonary Embolism

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9PLAT, F2, MTHFR, F5, NPPB
2thrombophlebitis30.9APOH
3patent foramen ovale30.8F5
4thrombocytopenia30.7SERPINC1, F2, F3, FGA, PF4, F10
5protein s deficiency30.7SERPINC1, F5, F9
6thrombophilia30.6SERPINF2, SERPINC1, PLAT, F2, F3, FGA
7myocardial infarction30.6SERPINF2, SERPINC1, PLAT, F3, FGA, FGB
8endocarditis30.5F10
9pneumonia30.5FGA
10stroke, ischemic30.5F2, F5
11antithrombin iii deficiency30.5SERPINC1, F2, F10, MTHFR, F5, APOH
12polycythemia vera30.4PF4
13protein c deficiency30.4SERPINC1, F2, MTHFR, F5, APOH, F9
14hyperhomocysteinemia30.4SERPINC1, PLAT, F2, CBS, MTHFR, F5
15disseminated intravascular coagulation30.4SERPINF2, SERPINC1, PLAT, F2, F3, FGA
16hepatitis30.3F2, F10, F9
17antiphospholipid syndrome30.3SERPINC1, PLAT, F2, F3, PF4, F10
18obesity30.2CBS, FABP3
19adenocarcinoma30.2PF4, F13A1, TNXA
20nephrotic syndrome30.2SERPINF2, SERPINC1, FGA, F9
21arthritis30.1F10
22myeloma30.1PF4
23respiratory failure30.1SERPINC1, F3
24sagittal sinus thrombosis30.1SERPINC1, F5
25coronary thrombosis30.1SERPINC1, PLAT, F3
26dilated cardiomyopathy30.1FGA, FABP3, NPPB, TNNI3
27factor xi deficiency30.1F2, F3, F5, F9
28von willebrand's disease30.1F2, F3, F5, F9
29rheumatoid arthritis30.1PF4, F13A1, F10, MTHFR, APOH
30peritonitis29.9F2
31hepatitis a29.9F2
32myocarditis29.9NPPB, TNNI3
33factor v deficiency29.9F2, F3, F5
34deficiency anemia29.9F2, F3, F9
35portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5
36acute leukemia29.9FGA, MTHFR
37prothrombin deficiency29.9SERPINC1, F2, F5, APOH
38hepatic vein thrombosis29.9SERPINC1, PLAT
39factor vii deficiency29.9SERPINC1, F2, F3, F10, F5, F9
40ischemia29.9PLAT, FGA, PF4, CBS, F10, FABP3
41liver cirrhosis29.9SERPINF2, SERPINC1, F2, F3, F10, F9
42thrombocytosis29.9SERPINF2, SERPINC1, F2, F3, FGA, PF4
43hypertrophic cardiomyopathy29.9TNNI3
44leukemia29.9SERPINF2, FGA, PF4, CBS, F10, MTHFR
45coronary artery disease29.9PLAT, F3, FGA, PF4, CBS, F10
46acute myocardial infarction29.9SERPINF2, SERPINC1, PLAT, F3, FGA, PF4
47factor v leiden thrombophilia29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
48thromboembolism29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
49venous thrombosis29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
50pulmonary embolism and infarction10.8

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Clinical Features for Pulmonary Embolism

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Drugs & Therapeutics for Pulmonary Embolism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Pulmonary Embolism

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Anatomical Context for Pulmonary Embolism

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Embolism:

32
Lung, Heart, Brain, Testes, Liver, Ovary, Breast, Bone, Pancreas, Thyroid, Kidney, Colon, Prostate, Spinal cord, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Embolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2PLAT, CBS, FABP3
2MP:000538910.2MTHFR, F10, CBS, FGA, SERPINC1
3MP:000537010.1SERPINC1, FGA, CBS, F5, FABP3, F9
4MP:000538510.1F2, F9, TNNI3, NPPB, FABP3, F10
5MP:000539710.0F9, F13A1, CBS, PF4, FGA, F3
6MP:001077110.0FABP3, CBS, FGA, F2
7MP:00107689.8MTHFR, F5, FABP3, APOH, TNNI3, F9
8MP:00053769.8F10, MTHFR, F5, FABP3, APOH, F9

Publications for Pulmonary Embolism

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50PubMed
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Articles related to Pulmonary Embolism:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
The impact of saddle embolism on the major adverse event rate of patients with non-high-risk pulmonary embolism. (24058095)
2013
2
Volumetric reconstruction of the right ventricle improves reproducibility of interventricular septum bowing in patients with pulmonary embolism. (23740496)
2013
3
Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia. (23429400)
2013
4
Doxycycline prevents acute pulmonary embolism-induced mortality and right ventricular deformation in rats. (23568586)
2013
5
Effectiveness of MR angiography for the primary diagnosis of acute pulmonary embolism: clinical outcomes at 3 months and 1 year. (23553735)
2013
6
Native-valve tricuspid endocarditis due to Neisseria Sicca with bilateral pulmonary embolism. (24007771)
2013
7
Diagnosis and risk stratification in acute pulmonary embolism: the role of echocardiography. (23651987)
2013
8
Transbronchial treatment of a bleeding pulmonary mycetoma refractory to arterial embolization. (24070516)
2013
9
Comment on "a new electrocardiogram finding for massive pulmonary embolism: ST elevation in lead aVR with ST depression in leads I and V(4) to V(6)". (23478106)
2013
10
Pulmonary embolism at follow-up outpatient CT pulmonary angiography: implications on patient risk stratification. (23912133)
2013
11
Pulmonary embolism presenting as recurrent transient loss of consciousness: syncope and seizure. (23286503)
2013
12
A rare case of bilateral pulmonary sequestration managed with embolization and surgical resection in a patient. (24368978)
2013
13
Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism. (24092475)
2013
14
Outpatient treatment of symptomatic pulmonary embolism: a systematic review and meta-analysis. (24035045)
2013
15
Leukocytes and systemic inflammatory response syndrome as prognostic factors in pulmonary embolism patients. (24325351)
2013
16
The use of bedside ultrasound in the evaluation of patients presenting with signs and symptoms of pulmonary embolism. (24106619)
2013
17
Unrecognized pulmonary embolism may have simulated arrhythmogenic pneumonia. (23968908)
2013
18
Long-term clinical course of acute pulmonary embolism. (23791363)
2013
19
Pretest probability assessment combined with point-of-care D-dimer testing allows primary care physicians to rule out pulmonary embolism. (23360711)
2013
20
Mortality due to pulmonary embolism, myocardial infarction, and stroke among incident dialysis patients: a rebuttal. (23557154)
2013
21
Clinical characteristics of septic pulmonary embolism in adults: A systematic review. (24183289)
2013
22
Septic pulmonary embolism secondary to Staphylococcus aureus septic thrombophlebitis in a pediatric patient. (24145945)
2013
23
Factors associated with elevated pulmonary arterial pressure levels on the echocardiographic assessment in patients with prior pulmonary embolism. (23466216)
2013
24
Predictive value of troponins and simplified pulmonary embolism severity index in patients with normotensive pulmonary embolism. (23714356)
2013
25
Pulmonary embolism following histoacryl glue embolization for a large thigh arteriovenous malformation. (23099967)
2012
26
Patent foramen ovale and major pulmonary embolism. (20817561)
2011
27
Recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR-677C>T and 1298A>C. (20449891)
2010
28
Clinical usefulness of prothrombin fragment 1+2 in patients with suspected pulmonary embolism. (19394681)
2010
29
E-page original images. Impending thrombus through a patent foramen ovale complicated by pulmonary embolism: successful treatment with thrombolytic application. (21062689)
2010
30
Heparin-induced thrombocytopenia associated with pulmonary embolism. (20043330)
2010
31
Cardiac troponin I levels in acute pulmonary embolism. (20222345)
2009
32
Pulmonary artery sarcoma mimicking a pulmonary embolism. (18453737)
2008
33
Peripartum cardiomyopathy presenting with pulmonary embolism: an unusual case. (18475217)
2008
34
Pulmonary embolism after tadalafil ingestion. (18548330)
2008
35
Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. (17127709)
2007
36
Tenecteplase to treat pulmonary embolism in the emergency department. (17221330)
2007
37
Paradoxical embolus illustrating speed of action of recombinant tissue plasminogen activator in massive pulmonary embolism. (17513552)
2007
38
One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. (16868938)
2006
39
Efficacy of pneumatic compression stocking prophylaxis in the prevention of deep venous thrombosis and pulmonary embolism following 139 lumbar laminectomies with instrumented fusions. (16462215)
2006
40
Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department. (16574759)
2006
41
The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism. (14597977)
2003
42
Transcatheter arterial embolization of pulmonary sequestration in neonates: long-term follow-up results. (12631642)
2003
43
Coagulation factor V Leiden mutation in sudden fatal pulmonary embolism and in a general northern European population sample. (10664892)
1999
44
Streptokinase vs alteplase in massive pulmonary embolism. A randomized trial assessing right heart haemodynamics and pulmonary vascular obstruction. (9243149)
1997
45
Factor V Leiden mutation in women with idiopathic pulmonary embolism. (9365004)
1997
46
Pulmonary embolism disclosing activated protein C resistance]. (8999481)
1996
47
Thrombolysis in pulmonary embolism: an adolescent with protein S deficiency. (7847117)
1994
48
Pulmonary tumor embolism to arterial vessels and carcinomatous lymphangitis. A comparative clinicopathological study. (8343048)
1993
49
Pulmonary tumor embolism to alveolar septal capillaries. An unusual cause of sudden cor pulmonale. (1733415)
1992
50
Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric (t-PA/u-PA) plasminogen activator in a hamster pulmonary embolism model. (1906351)
1991

Genetic Variations for Pulmonary Embolism

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Expression for genes affiliated with Pulmonary Embolism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, PLAT
210.3FGB, FGA, PLAT
3
Cell adhesion ECM remodeling
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10.3PLAT, FGA, FGB
4
Hide members
10.3FGB, FGA, F2
510.3FGB, FGA, F2
610.3F2, F10, F9
710.3MTHFR, CBS, F2, PLAT
8
Hide members
10.2F9, F10, F3, F2
9
Hide members
10.2FGB, FGA, F3, F2, SERPINF2
10
Hide members
10.2PF4, F13A1, F10, F5, F9
11
Hide members
10.1F5, F13A1, PF4, FGB, FGA, SERPINF2
12
Hide members
10.0F5, SERPINC1, F2, F3, FGA, FGB
13
Hide members
10.0F9, F5, F10, F13A1, FGB, FGA
14
Hide members
9.9FGA, FGB, F13A1, F10, F5, F9
15
Hide members
9.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA

Compounds for genes affiliated with Pulmonary Embolism

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1coumarins4410.6F9, F3, F10, APOH
2warfarin44 49 11 2413.6PF4, FGA, SERPINC1, APOH, F9
3spectrozyme4410.6PLAT, SERPINC1, F2, F3, F5, F10
4kaolin4410.6APOH, F5, F10, F3, F2, F9
5ptca4410.6APOH, NPPB, PF4, FGA, PLAT, SERPINF2
6dextran sulfate4410.6F9, APOH, F5, F10
7ancrod4410.6F5, F10, FGA, F2, PLAT, SERPINC1
8ristocetin4410.6F2, PLAT, SERPINC1, SERPINF2, F3, F5
9heparinoids4410.6F5, F10, F13A1, F3, F2, SERPINC1
10ecarin4410.5F5, F10, SERPINC1, F2, F3
11fibrinopeptide a4410.5PF4, FGA, F2, PLAT, SERPINC1, SERPINF2
12tirofiban44 1111.5NPPB, F10, PF4, F3, F2, PLAT
13batroxobin4410.5F2, F5, PLAT, FGB, FGA
14protamine sulfate4410.5F5, F10, PF4, F3, F2, PLAT
15ppack4410.5FGA, F10, F3, F2, SERPINC1, PLAT
16epsilon aminocaproic acid4410.5F2, SERPINC1, SERPINF2, F9, F3, PLAT
17gamma-carboxyglutamic acid4410.5F9, TNXA, F5, F10, PF4, F3
18ximelagatran44 1111.5F5, SERPINC1, F2, F3, F10
19organon4410.5F9, F10, F3, F2, SERPINC1
20argatroban44 1111.5F5, F10, FGA, F3, F2, SERPINC1
21serine4410.5CBS, F10, F9, FGA
22desmopressin44 59 28 1113.5SERPINF2, SERPINC1, PLAT, F2, F3, F5
23danaparoid4410.5TNXA, F5, F10, PF4, F3, F2
24coumarin44 2 49 2413.4F2, F10, F5, F9, F3, SERPINC1
25heparin44 28 11 2413.4F10, MTHFR, APOH, F9, F13A1, PF4
26bivalirudin44 1111.4SERPINC1, TNXA, F5, F10, FGA, F3
27ticlopidine44 1111.4F3, SERPINC1, PLAT, FGA, PF4, APOH
28homocysteine44 2411.4F9, APOH, NPPB, F5, MTHFR, CBS
29p0024410.4PLAT, FABP3, APOH, NPPB, PF4, MTHFR
30efegatran4410.4SERPINC1, F10, PLAT, F3
31abciximab44 1111.4PLAT, F10, PF4, SERPINC1, F3, F2
32fondaparinux4410.4TNXA, F5, F10, PF4, F3, F2
33tranexamic acid44 1111.4F2, SERPINC1, F9, F3, PLAT
34dermatan sulfate4410.4PLAT, SERPINC1, F2, F3, PF4, TNXA
3511-dehydrothromboxane b24410.3CBS, PF4, APOH, F2, FGA
36clopidogrel49 44 11 2413.3SERPINC1, F3, PLAT, F2, TNXA, F10
37protamine4410.3TNXA, F5, F10, PF4, FGA, F3
38desirudin4410.3F10, FGA, F3, PLAT
39kininogen4410.3F5, APOH, F9, F13A1, PF4, F3
40aprotinin44 1111.3SERPINC1, SERPINF2, F3, FGA, PLAT, F9
41citrate4410.3F10, F5, F9, F2, PF4, F3
42inogatran4410.3F2, F5, F3, SERPINC1
43prostacyclin4410.3APOH, NPPB, F5, PF4, PLAT, F3
44hirudin4410.2F9, TNXA, F5, F10, PF4, FGB
45thromboxane44 2411.1APOH, SERPINF2, CBS, PF4, FGA, PLAT
46aspirin44 49 28 2413.1SERPINC1, F3, FGA, PF4, F13A1, F10
47cacl24410.1F3, FGA, F10, F5, F9
48creatinine4410.1F3, FGA, PF4, MTHFR, F5, FABP3
49fibrinogen449.9PLAT, SERPINC1, F2, F3, F9, TNXA
50cholesterol44 28 11 2412.6MTHFR, CBS, FABP3, PF4, FGA, PLAT

GO Terms for genes affiliated with Pulmonary Embolism

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16Gene Ontology
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Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4FGB, FGA, SERPINF2
2intrinsic to external side of plasma membraneGO:03123310.4F3, F10
3platelet alpha granuleGO:03109110.4FGA, FGB
4platelet alpha granule lumenGO:03109310.3SERPINF2, F5, F13A1, PF4, FGB, FGA
5troponin complexGO:00586110.2TNNI3, TNNC1
6cell surfaceGO:00998610.2APOH, FGB, FGA, F3, PLAT, SERPINF2
7extracellular spaceGO:00561510.1APOH, NPPB, F5, PF4, FGB, FGA
8Golgi lumenGO:00579610.0F2, F10, F9
9extracellular regionGO:00557610.0F13A1, F10, F5, NPPB, F9, PF4

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.5APOH, F2, SERPINF2
2blood coagulation, extrinsic pathwayGO:00759810.5F3, F10, F9
3blood coagulation, intrinsic pathwayGO:00759710.5F9, APOH, F10, F2
4fibrinolysisGO:04273010.5F2, PLAT, SERPINF2
5peptidyl-glutamic acid carboxylationGO:01718710.5F2, F10, F9
6platelet degranulationGO:00257610.4F5, F13A1, PF4, FGB, FGA, SERPINF2
7negative regulation of angiogenesisGO:01652510.4PF4, NPPB, APOH
8regulation of blood vessel sizeGO:05088010.4CBS, NPPB
9homocysteine metabolic processGO:05066710.4MTHFR, CBS
10platelet activationGO:03016810.3F5, F13A1, PF4, FGB, FGA, F2
11plasminogen activationGO:03163910.3APOH, PLAT
12positive regulation of blood coagulationGO:03019410.1F2, APOH
13blood coagulationGO:00759610.1SERPINF2, F9, F5, F10, F13A1, PF4

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.4TNNC1, TNNI3
2serine-type endopeptidase activityGO:00425210.4PLAT, F2, F10, F9
3modified amino acid bindingGO:07234110.4MTHFR, CBS
4receptor bindingGO:00510210.3F2, FGA, FGB, NPPB
5protease bindingGO:00202010.0F3, SERPINC1, SERPINF2
6protein bindingGO:0055159.6TNNI3, TNNC1, APOH, FABP3, F5, F10

Products for genes affiliated with Pulmonary Embolism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Embolism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet