MCID: PLM033
MIFTS: 66

Pulmonary Embolism malady

Cardiovascular diseases category
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Summaries for Pulmonary Embolism

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MedlinePlus:33 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards based summary: Pulmonary Embolism, also known as pulmonary artery embolism, is related to sagittal sinus thrombosis and cardiogenic shock. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs dicumarol and heparin and the compounds ancrod and fibrinopeptide a have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are muscle and integument.

CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:65 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

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Pulmonary Embolism, Aliases & Descriptions:

Name: Pulmonary Embolism 8 10 44 33 62
 
Pulmonary Artery Embolism 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:9477
NCIt39 C50713
MeSH34 D011655
ICD1025 I26, I26.0, I26.9

Related Diseases for Pulmonary Embolism

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Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1sagittal sinus thrombosis30.9F5
2cardiogenic shock30.7PLAT, NPPB
3antithrombin iii deficiency30.6F2, F5
4afibrinogenemia30.6FGB
5hypertension30.6F2, PLAT, F5, NPPB
6coronary thrombosis30.6F3, PLAT
7protein s deficiency30.5F5, F3, F2
8protein c deficiency30.5F5, F2
9thrombocytopenia30.5F5, F3, F2
10hyperhomocysteinemia30.4F2, PLAT, F5
11thromboembolism30.2F2, SERPINF2, F3, PLAT, F5
12von willebrand's disease30.1F2, F3
13venous thrombosis30.1F2, SERPINF2, F3, PLAT, F5, FGB
14portal vein thrombosis30.1F2, F5
15ischemia30.0FABP3, PLAT, NPPB
16antiphospholipid syndrome30.0F2, F3, PLAT, F5
17factor xi deficiency30.0F2, F3, F5
18thrombophilia29.9F2, SERPINF2, F3, PLAT, F5
19thrombocytosis29.9F2, SERPINF2, F3
20factor vii deficiency29.7F5, F3, F2
21disseminated intravascular coagulation29.7F2, SERPINF2, F3, PLAT, F5
22myocardial infarction29.7SERPINF2, FABP3, F3, PLAT, F5, NPPB
23liver cirrhosis29.5F3, SERPINF2, F2
24acute myocardial infarction29.5SERPINF2, FABP3, F3, PLAT, NPPB
25factor v leiden thrombophilia29.2F2, SERPINF2, F3, PLAT, F5
26sepsis29.1F2, SERPINF2, F3, F5, NPPB
27pulmonary embolism and infarction10.8
28pulmonary hypertension10.6
29thrombophlebitis10.6
30patent foramen ovale10.6
31chronic thromboembolic pulmonary hypertension10.6
32cor pulmonale10.6
33central retinal artery occlusion10.5PLAT
34heparin-induced thrombocytopenia10.5
35cerebritis10.5
36aneurysm10.5
37venous thromboembolism10.5
38cardiac rupture10.5PLAT
39retinal vein occlusion10.4F5
40pneumonia10.4
41sarcoma10.4
42endophthalmitis10.4PLAT
43acute cor pulmonale10.4
44endocarditis10.4
45homocysteinemia10.4F5
46syncope10.4
47hepatitis10.3
48right bundle branch block10.3
49central retinal vein occlusion10.3PLAT, F5
50klippel-trenaunay syndrome10.3

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Symptoms for Pulmonary Embolism

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Drugs & Therapeutics for Pulmonary Embolism

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Genetic Tests for Pulmonary Embolism

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Anatomical Context for Pulmonary Embolism

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MalaCards organs/tissues related to Pulmonary Embolism:

32
Heart, Lung, Brain, Testes, Liver, Bone, Neutrophil, Spinal cord, Colon, Kidney, Pancreas, Thyroid, Breast, Ovary, Prostate, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Embolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4FABP3, F3, PLAT, NPPB
2MP:00107718.2F5, F3, FABP3, F2
3MP:00053857.4NPPB, F5, PLAT, F3, FABP3, F2
4MP:00053767.2F2, SERPINF2, FABP3, F3, PLAT, F5

Publications for Pulmonary Embolism

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Articles related to Pulmonary Embolism:

(show top 50)    (show all 1023)
idTitleAuthorsYear
1
Normal blood D-dimer concentrations: do they exclude pulmonary embolism? (24384418)
2014
2
ECG manifestations in submassive and massive pulmonary embolism. Report of 4 cases and review of literature. (23890684)
2014
3
Hospital costs of acute pulmonary embolism. (23331440)
2013
4
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
5
Pulmonary embolism hotline 2012. Recent and expected trials. (23337923)
2013
6
Catheter-directed intervention and thrombolysis for the treatment of massive pulmonary embolism that caused cardiac arrest. (24112187)
2013
7
The impact of saddle embolism on the major adverse event rate of patients with non-high-risk pulmonary embolism. (24058095)
2013
8
Prognostic value of the Charlson comorbidity index in pulmonary embolism. (23485768)
2013
9
A forgotten guidewire causing intracardiac multiple thrombi with paradoxical and pulmonary embolism. (23395220)
2013
10
Are vena cava filters effective in the treatment of pulmonary embolism? (24054953)
2013
11
Are all pulmonary embolism clinical decision rules equal? (23972135)
2013
12
Pulmonary embolism, part II: Management. (23940439)
2013
13
Validation of two clinical prognostic models in patients with acute symptomatic pulmonary embolism. (23664248)
2013
14
Volumetric reconstruction of the right ventricle improves reproducibility of interventricular septum bowing in patients with pulmonary embolism. (23740496)
2013
15
Plasma levels of mitochondrial and nuclear DNA in patients with massive pulmonary embolism in the emergency department: a prospective cohort study. (23705965)
2013
16
Point: should systemic lytic therapy be used for submassive pulmonary embolism? Yes. (23381309)
2013
17
Importance of history in the diagnosis of pulmonary embolism. (23512456)
2013
18
Case fatality rate with vena cava filters in hospitalized stable patients with cancer and pulmonary embolism. (23968903)
2013
19
Subsegmental pulmonary embolism: is the emperor still naked? (23856806)
2013
20
Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia. (23429400)
2013
21
Congenital complete absence of pericardium masquerading as pulmonary embolism. (23580923)
2013
22
Fatal pulmonary embolism update: 10 years of autopsy experience at an academic medical center. (24040503)
2013
23
Benefits of texture analysis of dual energy CT for Computer-Aided pulmonary embolism detection. (24110602)
2013
24
Catheter-directed approaches to pulmonary embolism. (23498312)
2013
25
Wolff-Parkinson-White syndrome and acute pulmonary embolism: a case report. (22816549)
2012
26
Hypereosinophilic syndrome presenting with large left ventricular apical thrombus and pulmonary embolism. (21854430)
2011
27
The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism. (21743331)
2011
28
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
29
Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk. (20691835)
2010
30
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
31
Postoperative pulmonary embolism in a three year old with Klippel-Trenaunay syndrome. (23754873)
2009
32
N-terminal pro-B-type natriuretic peptide predicts the burden of pulmonary embolism. (19214022)
2009
33
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
34
Persistent NT-proBNP elevation in acute pulmonary embolism predicts early death. (17507005)
2007
35
Brain natriuretic peptide in hemodynamically stable acute pulmonary embolism. (16405522)
2006
36
Biohumoral markers and right ventricular dysfunction in acute pulmonary embolism: the answer to thrombolytic therapy]. (15253142)
2004
37
Pulmonary Takayasu's arteritis masquerading as acute pulmonary embolism. (17039181)
2001
38
The role of lung scintigraphy in the diagnosis of nephrotic syndrome with pulmonary embolism. (10698409)
2000
39
Life threatening massive pulmonary embolism treated with reteplase: a case report. (16597314)
2000
40
Oropharyngeal Necrobacillosis with Septic Thrombophlebitis and Pulmonary Embolic Abscesses: Lemierre's Syndrome in a New Zealand White Rabbit. (12086416)
1999
41
Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism. (10385761)
1999
42
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
43
Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis. (8562833)
1995
44
Acute pulmonary embolism. (8076500)
1994
45
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989
46
Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. (4013602)
1985
47
REFRACTORY DYSPNEA AND ORTHOPNEA; EVIDENCE OF RECURRENT PULMONARY EMBOLISM AND INFARCTION. (14340861)
1965
48
Pulmonary embolism and infarction. (13824271)
1960
49
Pulmonary embolism and infarction; diagnosis and management. (13238705)
1955
50
Pulmonary embolism with acute cor pulmonale and extremely rapid ventricular rate in a young, active apparently healthy adult. (15395458)
1949

Variations for Pulmonary Embolism

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Expression for genes affiliated with Pulmonary Embolism

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Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

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Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SERPINF2, PLAT
29.6FGB, PLAT
3
Show member pathways
thioredoxin pathway37
9.3PLAT, F2
4
Show member pathways
9.1FGB, F2
59.1FGB, F2
6
Show member pathways
9.0FGB, F5, SERPINF2
7
Show member pathways
8.1F2, F3, F5, FGB
8
Show member pathways
7.2FGB, F5, PLAT, F3, SERPINF2, F2
9
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.2F2, SERPINF2, F3, PLAT, F5, FGB
10
Show member pathways
7.2F2, SERPINF2, F3, PLAT, F5, FGB

Compounds for genes affiliated with Pulmonary Embolism

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Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1ancrod449.2F5, PLAT, F2
2fibrinopeptide a449.1SERPINF2, PLAT, F2
3p002449.1PLAT, F5, NPPB, FABP3
4heparin sodium449.1F2, F3, PLAT
5dextran 70449.1PLAT, F3, F2
6mnpt449.0F3, F2
7ptca449.0PLAT, NPPB, F3, SERPINF2
8inogatran449.0F5, F3, F2
9ecarin449.0F5, F3, F2
10ppack449.0PLAT, F2, F3
11tranexamic acid44 119.9PLAT, F2, F3
12danaparoid448.9F3, F2, F5
13kaolin448.9F5, F3, F2
14ximelagatran44 119.9F5, F2, F3
15heparinoids448.9F2, F3, F5
16acenocoumarol44 50 1110.9F2, F5, F3
17coumarins448.9F2, F5, F3
18nitroglycerin44 119.8F3, PLAT, NPPB
19abciximab44 119.8PLAT, F3, F2
20prostacyclin448.8F5, NPPB, PLAT, F3
21batroxobin448.8F2, PLAT, FGB, F5
22gamma-carboxyglutamic acid448.8F5, F3, F2
23tirofiban44 119.7F2, NPPB, PLAT, F3
24clopidogrel44 50 24 1111.7F2, PLAT, F3
25spectrozyme448.7PLAT, F3, F2, F5
26fondaparinux448.7F2, F3, PLAT, F5
27bivalirudin44 119.7F3, PLAT, F2, F5
28argatroban44 119.7F2, F5, PLAT, F3
29protamine sulfate448.7PLAT, F5, F3, F2
30coumarin44 2 50 2411.6F2, F3, F5
31levonorgestrel44 61 28 1111.6F2, F3, F5, PLAT
32protamine448.6PLAT, F3, F2, F5
33dermatan sulfate448.6PLAT, F3, F2, F5
34epsilon aminocaproic acid448.6PLAT, SERPINF2, F2, F3
35warfarin44 50 24 1111.6F5, F2, PLAT, F3
36cardiolipin44 119.5F5, F3, F2
37simvastatin44 50 61 28 24 1113.4PLAT, F2, F5, F3
38citrate448.4F2, FABP3, F5, F3
39homocysteine44 249.2F2, NPPB, F5, PLAT, F3
40aspirin44 50 28 2411.2F2, NPPB, F3, PLAT, F5
41ristocetin448.2F3, PLAT, SERPINF2, F5, F2
42desmopressin44 61 28 1111.2F2, PLAT, F3, SERPINF2, F5
43kininogen448.1SERPINF2, F2, F5, PLAT, F3
44epinephrine44 24 1110.0SERPINF2, F3, NPPB, F2, F5
45creatinine447.8F3, F2, FABP3, PLAT, F5, NPPB
46aprotinin44 118.7SERPINF2, NPPB, F5, PLAT, F3, F2
47hirudin447.6FGB, SERPINF2, F3, PLAT, F5, F2
48fibrinogen447.6FGB, SERPINF2, F3, PLAT, F2, F5
49heparin44 28 24 1110.2NPPB, F5, PLAT, F3, SERPINF2, F2
50serine447.1PLAT, SERPINF2, F2, NPPB, FGB, F3

GO Terms for genes affiliated with Pulmonary Embolism

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Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.1FGB, SERPINF2
2platelet alpha granule lumenGO:0310939.0FGB, F5, SERPINF2
3blood microparticleGO:0725628.6FGB, SERPINF2, F2
4cell surfaceGO:0099868.4SERPINF2, F3, PLAT, FGB
5extracellular regionGO:0055767.5F2, SERPINF2, PLAT, F5, NPPB, FGB
6extracellular spaceGO:0056156.9FGB, F2, SERPINF2, F3, PLAT, F5

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of proteolysisGO:0458619.2PLAT, F2
2negative regulation of fibrinolysisGO:0519189.1F2, SERPINF2
3acute-phase responseGO:0069539.1SERPINF2, F2
4platelet degranulationGO:0025769.0FGB, F5, SERPINF2
5fibrinolysisGO:0427308.9PLAT, SERPINF2, F2
6positive regulation of collagen biosynthetic processGO:0329678.8SERPINF2, F2
7platelet activationGO:0301688.3F2, SERPINF2, F5, FGB
8blood coagulationGO:0075967.4FGB, F2, SERPINF2, F3, PLAT, F5

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3F3, SERPINF2
2serine-type endopeptidase activityGO:0042528.9F5, PLAT, F2
3receptor bindingGO:0051028.4FGB, NPPB, F2
4protein bindingGO:0055156.7F2, SERPINF2, FABP3, F3, PLAT, F5

Products for genes affiliated with Pulmonary Embolism

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Sources for Pulmonary Embolism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet