MCID: PLM033
MIFTS: 68

Pulmonary Embolism malady

Cardiovascular diseases category

Summaries for Pulmonary Embolism

About this section
Sources:
33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 A pulmonary embolism is a sudden blockage in a lung artery. the cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung. pulmonary embolism is a serious condition that can cause permanent damage to the affected lung low oxygen levels in your blood damage to other organs in your body from not getting enough oxygen if a clot is large, or if there are many clots, pulmonary embolism can cause death. half the people who have pulmonary embolism have no symptoms. if you do have symptoms, they can include shortness of breath, chest pain or coughing up blood. symptoms of a blood clot include warmth, swelling, pain, tenderness and redness of the leg. the goal of treatment is to break up clots and help keep other clots from forming. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Embolism, also known as pulmonary artery embolism, is related to hypertension and thrombophlebitis. An important gene associated with Pulmonary Embolism is PLAT (plasminogen activator, tissue), and among its related pathways are Dissolution of Fibrin Clot and Cell adhesion Plasmin signaling. The drugs heparin and heparin sodium and the compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are vision/eye and reproductive system.

CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

Wikipedia:63 Pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches by a... more...

Aliases & Classifications for Pulmonary Embolism

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Related Diseases for Pulmonary Embolism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Embolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9PLAT, F2, MTHFR, F5, NPPB
2thrombophlebitis30.9APOH
3patent foramen ovale30.8F5
4thrombocytopenia30.7SERPINC1, F2, F3, FGA, PF4, F10
5protein s deficiency30.7SERPINC1, F5, F9
6thrombophilia30.6SERPINF2, SERPINC1, PLAT, F2, F3, FGA
7myocardial infarction30.6SERPINF2, SERPINC1, PLAT, F3, FGA, FGB
8endocarditis30.5F10
9pneumonia30.5FGA
10stroke, ischemic30.5F2, F5
11antithrombin iii deficiency30.5SERPINC1, F2, F10, MTHFR, F5, APOH
12polycythemia vera30.4PF4
13protein c deficiency30.4SERPINC1, F2, MTHFR, F5, APOH, F9
14hyperhomocysteinemia30.4SERPINC1, PLAT, F2, CBS, MTHFR, F5
15disseminated intravascular coagulation30.4SERPINF2, SERPINC1, PLAT, F2, F3, FGA
16hepatitis30.3F2, F10, F9
17antiphospholipid syndrome30.3SERPINC1, PLAT, F2, F3, PF4, F10
18obesity30.2CBS, FABP3
19adenocarcinoma30.2PF4, F13A1, TNXA
20nephrotic syndrome30.2SERPINF2, SERPINC1, FGA, F9
21arthritis30.1F10
22myeloma30.1PF4
23respiratory failure30.1SERPINC1, F3
24sagittal sinus thrombosis30.1SERPINC1, F5
25coronary thrombosis30.1SERPINC1, PLAT, F3
26dilated cardiomyopathy30.1FGA, FABP3, NPPB, TNNI3
27factor xi deficiency30.1F2, F3, F5, F9
28von willebrand's disease30.1F2, F3, F5, F9
29rheumatoid arthritis30.1PF4, F13A1, F10, MTHFR, APOH
30peritonitis29.9F2
31hepatitis a29.9F2
32myocarditis29.9NPPB, TNNI3
33factor v deficiency29.9F2, F3, F5
34deficiency anemia29.9F2, F3, F9
35portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5
36acute leukemia29.9FGA, MTHFR
37prothrombin deficiency29.9SERPINC1, F2, F5, APOH
38hepatic vein thrombosis29.9SERPINC1, PLAT
39factor vii deficiency29.9SERPINC1, F2, F3, F10, F5, F9
40ischemia29.9PLAT, FGA, PF4, CBS, F10, FABP3
41liver cirrhosis29.9SERPINF2, SERPINC1, F2, F3, F10, F9
42thrombocytosis29.9SERPINF2, SERPINC1, F2, F3, FGA, PF4
43hypertrophic cardiomyopathy29.9TNNI3
44leukemia29.9SERPINF2, FGA, PF4, CBS, F10, MTHFR
45coronary artery disease29.9PLAT, F3, FGA, PF4, CBS, F10
46acute myocardial infarction29.9SERPINF2, SERPINC1, PLAT, F3, FGA, PF4
47factor v leiden thrombophilia29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
48thromboembolism29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
49venous thrombosis29.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA
50pulmonary embolism and infarction10.8

Graphical network of the top 20 diseases related to Pulmonary Embolism:



Diseases related to pulmonary embolism

Clinical Features for Pulmonary Embolism

About this section

Drugs & Therapeutics for Pulmonary Embolism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Pulmonary Embolism

About this section

Anatomical Context for Pulmonary Embolism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Embolism:

32
Lung, Heart, Brain, Testes, Liver, Bone, Ovary, Breast, Spinal cord, Prostate, Pancreas, Colon, Thyroid, Kidney, Cervix

Animal Models for Pulmonary Embolism or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Embolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2FABP3, CBS, PLAT
2MP:000538910.2MTHFR, F10, CBS, FGA, SERPINC1
3MP:000537010.1F9, FABP3, F5, CBS, FGA, SERPINC1
4MP:000538510.1F2, F9, TNNI3, NPPB, FABP3, F10
5MP:000539710.0PLAT, CBS, SERPINC1, F2, F3, FGA
6MP:001077110.0FABP3, CBS, F2, FGA
7MP:00107689.8APOH, F10, MTHFR, F5, FABP3, TNNI3
8MP:00053769.8FGA, F3, F2, PLAT, SERPINC1, SERPINF2

Publications for Pulmonary Embolism

About this section
Sources:
50PubMed
See all sources

Articles related to Pulmonary Embolism:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
Reduction in the length of stay with rivaroxaban as a single-drug regimen for the treatment of deep vein thrombosis and pulmonary embolism. (24432872)
2014
2
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
3
Are all pulmonary embolism clinical decision rules equal? (23972135)
2013
4
Hereditary hemorrhagic telangiectasia with pulmonary arteriovenous malformations and embolic strokes treated successfully with video-assisted thoracoscopic resection. (23676596)
2013
5
Variable ECG findings associated with pulmonary embolism. (23449833)
2013
6
Submassive pulmonary embolism: where's the tipping point? (23775195)
2013
7
Pulmonary embolectomy in high-risk acute pulmonary embolism: the effectiveness of a comprehensive therapeutic algorithm including extracorporeal life support. (23583612)
2013
8
Right ventricular perforation caused by pulmonary artery catheter three days after insertion in a patient with acute pulmonary embolism. (23693072)
2013
9
Pulmonary embolism rule-out criteria: a clinical decision rule that works. (23939640)
2013
10
The use of a low dose hydrocortisone to prevent pulmonary embolism in patients with multiple trauma. (23605143)
2013
11
Probability Scores and Diagnostic Algorithms in Pulmonary Embolism: Are They Followed in Clinical Practice? (24360086)
2013
12
Acute pulmonary embolism during warfarin therapy and long-term risk of recurrent fatal pulmonary embolism. (23740364)
2013
13
Pulmonary embolism in a patient with congenital afibrinogenemia. (23855372)
2013
14
Prediction of adverse clinical outcome in patients with acute pulmonary embolism: evaluation of high-sensitivity troponin I and quantitative CT parameters. (23238359)
2013
15
Pulmonary embolism. (23724389)
2013
16
Pulmonary embolism in the pediatric emergency department. (23999960)
2013
17
Arterial to end-tidal CO2 pressure gradient: a bedside parameter to monitor patients with massive pulmonary embolism. (23380099)
2013
18
Prediction of right ventricular dysfunction from radiographic estimates of right descending pulmonary artery in hemodynamically stable pulmonary embolism patients. (23558877)
2013
19
Diagnostic accuracy of three-dimensional contrast-enhanced MR angiography at 3-T for acute pulmonary embolism detection: comparison with multidetector CT angiography. (23958419)
2013
20
Pulmonary artery sarcoma masquerading as pulmonary embolism. (24180442)
2013
21
National Consensus on the Diagnosis, Risk Stratification and Treatment of Patients with Pulmonary Embolism. (24041726)
2013
22
Role of obesity in the etiology of deep vein thrombosis and pulmonary embolism: current epidemiological insights. (23625755)
2013
23
Suspicion of pulmonary embolism during treatment of pemphigoid gestationis. (24278048)
2013
24
A case of renal angiomyolipoma with intracardiac extension and asymptomatic pulmonary embolism. (23696940)
2013
25
Recurrent deep vein thrombosis and pulmonary embolism in a patient with Klinefelter's syndrome. (23052903)
2013
26
Recurrent pulmonary embolism due to echinococcosis secondary to hepatic surgery for hydatid cysts. (22992602)
2012
27
NT-pro-BNP levels in patients with acute pulmonary embolism are correlated to right but not left ventricular volume and function. (22740123)
2012
28
Ventilatory and cardiac responses to pulmonary embolism: consequences for gas exchange and blood pressure. (23367456)
2012
29
Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism. (20447541)
2010
30
Pulmonary embolism and acute cytomegalovirus infection in an immunocompetent patient. (21196823)
2010
31
Embolization of a symptomatic systemic to pulmonary (right-to-left) venous shunt caused by fibrosing mediastinitis and superior vena caval occlusion. (20123198)
2010
32
The value of ischemia-modified albumin compared with d-dimer in the diagnosis of pulmonary embolism. (18513410)
2008
33
Pulmonary arterial coil embolization for the management of persistent type I hepatopulmonary syndrome after liver transplantation. (18057294)
2007
34
Brain natriuretic peptide in hemodynamically stable acute pulmonary embolism. (16405522)
2006
35
A case report of a new pulmonary embolism occurring in a patient receiving continuous infusion of recombinant activated protein C. (16899129)
2006
36
Management of severe hemoptysis from pulmonary aspergilloma using endovascular embolization. (16810459)
2006
37
Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism. (14718328)
2004
38
Clinical and radiographic features mimicking pulmonary embolism as the first manifestation of Takayasu's arteritis. (15278757)
2004
39
Severe paradoxical intracranial embolism and pulmonary emboli during hip hemiarthroplasty. (14633765)
2003
40
Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty. (24383778)
2001
41
Thrombolysis in pulmonary embolism: a debatable indication. (11487035)
2001
42
A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency. (9569196)
1998
43
Sudden death due to pulmonary tumor embolism in a patient with endodermal sinus tumor of the ovary. (7811195)
1994
44
Pulmonary embolism after total hip replacement in a patient who had an ovarian cyst. A case report. (8408162)
1993
45
Recombinant tissue-type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial. (1607532)
1992
46
Hepatogenic pulmonary angiodysplasia treated with coil-spring embolization. (3581942)
1987
47
Right atrial septal aneurysm: an unusual cause of recurrent pulmonary embolism. (3996007)
1985
48
Pulmonary interstitial emphysema with gas embolism in hyaline membrane disease. (4579214)
1973
49
Interruption of double inferior vena cava for prevention of pulmonary embolism. (4654128)
1972
50
Reflex and direct cardiopulmonary effects of 5-OH-tryptamine (serotonin); their possible role in pulmonary embolism and coronary thrombosis. (13065459)
1953

Genetic Variations for Pulmonary Embolism

About this section

Expression for genes affiliated with Pulmonary Embolism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Embolism

Search GEO for disease gene expression data for Pulmonary Embolism.

Pathways for genes affiliated with Pulmonary Embolism

About this section
Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
See all sources

Pathways related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, PLAT
210.3FGB, FGA, PLAT
3
Cell adhesion ECM remodeling
Hide members
10.3PLAT, FGA, FGB
4
Hide members
10.3FGB, FGA, F2
510.3FGB, FGA, F2
610.3F2, F10, F9
710.3MTHFR, CBS, F2, PLAT
8
Hide members
10.2F9, F10, F3, F2
9
Hide members
10.2FGB, FGA, F3, F2, SERPINF2
10
Hide members
10.2PF4, F13A1, F10, F5, F9
11
Hide members
10.1F5, F13A1, PF4, FGB, FGA, SERPINF2
12
Hide members
10.0F5, SERPINC1, F2, F3, FGA, FGB
13
Hide members
10.0F9, F5, F10, F13A1, FGB, FGA
14
Hide members
9.9FGA, FGB, F13A1, F10, F5, F9
15
Hide members
9.9SERPINF2, SERPINC1, PLAT, F2, F3, FGA

Compounds for genes affiliated with Pulmonary Embolism

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1coumarins4410.6F9, F3, F10, APOH
2warfarin44 49 11 2413.6PF4, FGA, SERPINC1, APOH, F9
3spectrozyme4410.6PLAT, SERPINC1, F2, F3, F5, F10
4kaolin4410.6APOH, F5, F10, F3, F2, F9
5ptca4410.6APOH, NPPB, PF4, FGA, PLAT, SERPINF2
6dextran sulfate4410.6F9, APOH, F5, F10
7ancrod4410.6F5, F10, FGA, F2, PLAT, SERPINC1
8ristocetin4410.6F2, PLAT, SERPINC1, SERPINF2, F3, F5
9heparinoids4410.6F5, F10, F13A1, F3, F2, SERPINC1
10ecarin4410.5F5, F10, SERPINC1, F2, F3
11fibrinopeptide a4410.5PF4, FGA, F2, PLAT, SERPINC1, SERPINF2
12tirofiban44 1111.5NPPB, F10, PF4, F3, F2, PLAT
13batroxobin4410.5F2, F5, PLAT, FGB, FGA
14protamine sulfate4410.5F5, F10, PF4, F3, F2, PLAT
15ppack4410.5FGA, F10, F3, F2, SERPINC1, PLAT
16epsilon aminocaproic acid4410.5F2, SERPINC1, SERPINF2, F9, F3, PLAT
17gamma-carboxyglutamic acid4410.5F9, TNXA, F5, F10, PF4, F3
18ximelagatran44 1111.5F5, SERPINC1, F2, F3, F10
19organon4410.5F9, F10, F3, F2, SERPINC1
20argatroban44 1111.5F5, F10, FGA, F3, F2, SERPINC1
21serine4410.5CBS, F10, F9, FGA
22desmopressin44 59 28 1113.5SERPINF2, SERPINC1, PLAT, F2, F3, F5
23danaparoid4410.5TNXA, F5, F10, PF4, F3, F2
24coumarin44 2 49 2413.4F2, F10, F5, F9, F3, SERPINC1
25heparin44 28 11 2413.4F10, MTHFR, APOH, F9, F13A1, PF4
26bivalirudin44 1111.4SERPINC1, TNXA, F5, F10, FGA, F3
27ticlopidine44 1111.4F3, SERPINC1, PLAT, FGA, PF4, APOH
28homocysteine44 2411.4F9, APOH, NPPB, F5, MTHFR, CBS
29p0024410.4PLAT, FABP3, APOH, NPPB, PF4, MTHFR
30efegatran4410.4SERPINC1, F10, PLAT, F3
31abciximab44 1111.4PLAT, F10, PF4, SERPINC1, F3, F2
32fondaparinux4410.4TNXA, F5, F10, PF4, F3, F2
33tranexamic acid44 1111.4F2, SERPINC1, F9, F3, PLAT
34dermatan sulfate4410.4PLAT, SERPINC1, F2, F3, PF4, TNXA
3511-dehydrothromboxane b24410.3CBS, PF4, APOH, F2, FGA
36clopidogrel49 44 11 2413.3SERPINC1, F3, PLAT, F2, TNXA, F10
37protamine4410.3TNXA, F5, F10, PF4, FGA, F3
38desirudin4410.3F10, FGA, F3, PLAT
39kininogen4410.3F5, APOH, F9, F13A1, PF4, F3
40aprotinin44 1111.3SERPINC1, SERPINF2, F3, FGA, PLAT, F9
41citrate4410.3F10, F5, F9, F2, PF4, F3
42inogatran4410.3F2, F5, F3, SERPINC1
43prostacyclin4410.3APOH, NPPB, F5, PF4, PLAT, F3
44hirudin4410.2F9, TNXA, F5, F10, PF4, FGB
45thromboxane44 2411.1APOH, SERPINF2, CBS, PF4, FGA, PLAT
46aspirin44 49 28 2413.1SERPINC1, F3, FGA, PF4, F13A1, F10
47cacl24410.1F3, FGA, F10, F5, F9
48creatinine4410.1F3, FGA, PF4, MTHFR, F5, FABP3
49fibrinogen449.9PLAT, SERPINC1, F2, F3, F9, TNXA
50cholesterol44 28 11 2412.6MTHFR, CBS, FABP3, PF4, FGA, PLAT

GO Terms for genes affiliated with Pulmonary Embolism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.4FGB, SERPINF2, FGA
2intrinsic to external side of plasma membraneGO:03123310.4F3, F10
3platelet alpha granule lumenGO:03109310.3F5, F13A1, PF4, FGA, SERPINF2, FGB
4Golgi lumenGO:00579610.3F9, F10, F2
5troponin complexGO:00586110.2TNNI3, TNNC1
6cell surfaceGO:00998610.2APOH, FGB, FGA, F3, PLAT, SERPINF2
7extracellular spaceGO:00561510.1F3, F2, SERPINF2, SERPINC1, FGA, FGB
8platelet alpha granuleGO:03109110.1FGB, FGA
9extracellular regionGO:00557610.0FGB, SERPINF2, SERPINC1, F2, F13A1, F10

Biological processes related to Pulmonary Embolism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.5APOH, F2, SERPINF2
2blood coagulation, extrinsic pathwayGO:00759810.5F3, F10, F9
3blood coagulation, intrinsic pathwayGO:00759710.5F9, APOH, F10, F2
4fibrinolysisGO:04273010.5F2, PLAT, SERPINF2
5peptidyl-glutamic acid carboxylationGO:01718710.5F2, F10, F9
6platelet degranulationGO:00257610.4F5, F13A1, PF4, FGB, FGA, SERPINF2
7negative regulation of angiogenesisGO:01652510.4PF4, NPPB, APOH
8regulation of blood vessel sizeGO:05088010.4CBS, NPPB
9homocysteine metabolic processGO:05066710.4MTHFR, CBS
10platelet activationGO:03016810.3F5, F13A1, PF4, FGB, FGA, F2
11plasminogen activationGO:03163910.3APOH, PLAT
12positive regulation of blood coagulationGO:03019410.1F2, APOH
13blood coagulationGO:00759610.1SERPINF2, F9, F5, F10, F13A1, PF4

Molecular functions related to Pulmonary Embolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.4TNNC1, TNNI3
2serine-type endopeptidase activityGO:00425210.4PLAT, F2, F10, F9
3modified amino acid bindingGO:07234110.4MTHFR, CBS
4receptor bindingGO:00510210.3F2, FGA, FGB, NPPB
5protease bindingGO:00202010.0F3, SERPINC1, SERPINF2
6protein bindingGO:0055159.6TNNI3, TNNC1, APOH, FABP3, F5, F10

Products for genes affiliated with Pulmonary Embolism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Embolism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet