MCID: PLM034
MIFTS: 60

Pulmonary Emphysema malady

Summaries for Pulmonary Emphysema

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

MalaCards: Pulmonary Emphysema is related to bronchitis and pulmonary fibrosis. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs acetylcysteine and aminophylline and the compounds estrogen and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Pulmonary Emphysema

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

pulmonary emphysema 8 10 44 30 60


External Ids:

Disease Ontology8 DOID:9675
MeSH34 D011656
ICD9CM27 492.8

Related Diseases for Pulmonary Emphysema

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis30.7SERPINA1
2pulmonary fibrosis30.6SFTPD, MMP1, MMP9, HMOX1, ELANE, ELN
3alpha 1-antitrypsin deficiency30.6SERPINA1, SERPINB1, ELANE
4lung cancer30.5TIMP2, SFTPD, KEAP1, MMP8, MMP12, MMP9
5asthma30.3SFTPD, CTSG, MMP8, MMP12, MMP9, SERPINA1
6hypertension30.2MMP9
7interstitial lung disease30.0SFTPD, MMP9
8extrinsic allergic alveolitis30.0ELANE, CTSG, SFTPD
9sarcoma30.0LYZ, SLPI
10idiopathic pulmonary fibrosis30.0SFTPD, MMP1, MMP9, ELANE
11periodontitis30.0TIMP2, MMP8, MMP1, MMP9, SLPI, ELANE
12cystic fibrosis30.0SFTPD, CTSG, HMOX1, SLPI, SERPINA1, ELANE
13periodontal disease30.0TIMP2, CTSG, MMP8, MMP1, MMP9, SLPI
14pneumonia30.0SFTPD, CTSG, MMP8, MMP12, HMOX1, SLPI
15atherosclerosis30.0TIMP2, FGF23, MMP8, MMP12, MMP1, MMP9
16respiratory failure30.0SERPINA1, SFTPD
17interstitial emphysema10.7
18cutis laxa10.3
19berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.3
20marfan syndrome10.3
21bronchiolitis10.1
22diffuse pulmonary fibrosis10.1
23bronchial disease10.1
24pneumothorax10.1
25substernal goiter10.0
26neurofibromatosis10.0
27spontaneous tension pneumothorax10.0
28neuroendocrine carcinoma10.0
29compensatory emphysema10.0
30ruptured thoracoabdominal aortic aneurysm10.0
31cerebritis10.0
32small cell carcinoma10.0
33lymphangitis10.0
34large cell carcinoma10.0
35osteoporosis10.0
36aortic aneurysm10.0
37goiter10.0
38hemolytic anemia10.0
39mediastinitis10.0
40neuromuscular disease10.0
41obstructive lung disease10.0
42papilledema10.0
43pulmonary large cell neuroendocrine carcinoma10.0
44ruptured aortic aneurysm10.0
45synovial sarcoma10.0
46fbln5-related cutis laxa10.0
47cutis laxa, autosomal recessive, type ia10.0
48bronchopulmonary dysplasia10.0ELANE
49galactosemia10.0SERPINA1
50abdominal aortic aneurysm10.0MMP9

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Clinical Features for Pulmonary Emphysema

About this section

Drugs & Therapeutics for Pulmonary Emphysema

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Emphysema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Emphysema

Search NIH Clinical Center for Pulmonary Emphysema

Search CenterWatch for Pulmonary Emphysema

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

About this section

Anatomical Context for Pulmonary Emphysema

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Emphysema:

32
Lung, Bone, Testes, Endothelial, Skeletal muscle, Bone marrow, Placenta, Liver, Kidney, Colon, Heart, Fetal lung

Animal Models for Pulmonary Emphysema or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Emphysema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1SFTPD, MMP9, SERPINB1, ELN
2MP:00053769.9FGF23, MMP12, GPX2, HMOX1, SLPI, SERPINB1
3MP:00053879.8ELANE, TIMP2, SFTPD, CTSG, FGF23, MMP8
4MP:00107689.6FGF23, CRABP2, KEAP1, CTSG, MMP9, GPX2
5MP:00053979.5TIMP2, SFTPD, CTSG, FGF23, MMP12, MMP9

Publications for Pulmonary Emphysema

About this section
Sources:
50PubMed
See all sources

Articles related to Pulmonary Emphysema:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Improved correlation between CT emphysema quantification and pulmonary function test by density correction of volumetric CT data based on air and aortic density. (22613510)
2014
2
Unfolding the mechanisms of progression of pulmonary emphysema in COPD. (23024322)
2012
3
Combined pulmonary fibrosis and emphysema syndrome in systemic sclerosis. (23072220)
2012
4
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. (20713693)
2010
5
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. (20473305)
2010
6
Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. (21067581)
2010
7
Pulmonary function and emphysema in Williams-Beuren syndrome. (20186780)
2010
8
Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. (19897563)
2010
9
Fatal subcutaneous emphysema secondary to pulmonary nocardiosis in an immunocompromised patient--a case report. (19266837)
2009
10
Tomographic diagnosis of pulmonary emphysema. (19820806)
2009
11
Pulmonary interstitial emphysema and live birth. (19259033)
2008
12
Texture-based quantification of pulmonary emphysema on high-resolution computed tomography: comparison with density-based quantification and correlation with pulmonary function test. (18496044)
2008
13
Semi-quantitation of pulmonary perfusion heterogeneity on respiratory-gated inspiratory and expiratory perfusion SPECT in patients with pulmonary emphysema. (18092134)
2007
14
Pulmonary interstitial emphysema in preterm twins on continuous positive airway pressure. (17118744)
2006
15
Association between markers of emphysema and more severe chronic obstructive pulmonary disease. (16769715)
2006
16
Characterization of 133Xe gas washout in pulmonary emphysema with dynamic 133Xe SPECT functional images. (16340726)
2006
17
Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats. (15781752)
2005
18
Optimization and standardization of lung densitometry in the assessment of pulmonary emphysema. (15486529)
2004
19
A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. (15033705)
2003
20
CT imaging of pulmonary lobar interstitial emphysema in a spontaneous breathing preterm infant. (12357418)
2002
21
Subcutaneous emphysema, pneumomediastinum, and pulmonary emphysema in a young schipperke. (11908829)
2002
22
Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease. (11943590)
2002
23
Fractal analysis of nuclear medicine images for the diagnosis of pulmonary emphysema: interpretations, implications, and limitations. (10749249)
2000
24
Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. (10084478)
1999
25
Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. (10508317)
1999
26
Application of the fold plication method for unilateral lung volume reduction in pulmonary emphysema. (10215234)
1999
27
Effects of isoflurane on oxygenation during one-lung ventilation in pulmonary emphysema patients. (9834795)
1998
28
Incidental lung carcinoma detected at CT in patients selected for lung volume reduction surgery to treat severe pulmonary emphysema. (9577499)
1998
29
Pulmonary emphysema: comparison of preoperative quantitative CT and physiologic index values with clinical outcome after lung-volume reduction surgery. (9314991)
1997
30
Three-dimensional surface displays of perfusion SPET in the evaluation of patients with pulmonary emphysema for thoracoscopic lung volume reduction surgery. (9293502)
1997
31
Successful outcome of severe unilateral pulmonary interstitial emphysema after bi-lobectomy in a very low birthweight infant. (8683524)
1996
32
Can computed tomography quantify pulmonary emphysema? (7656960)
1995
33
123I]HIPDM pulmonary imaging demonstrates elastase-induced pulmonary emphysema. (8416418)
1993
34
Increased leukocyte elastase of the tracheal aspirate at birth and neonatal pulmonary emphysema. (8414828)
1993
35
Pulmonary interstitial emphysema: a review. (1495469)
1992
36
Metabolism of elastin and pulmonary emphysema]. (8614669)
1990
37
Biological effects of inhaled 239PuO2 in rats with pre-existing pulmonary emphysema. (2261243)
1990
38
Single breath N2 washout in papain-induced pulmonary emphysema. (2768646)
1989
39
Severe congenital cutis laxa with pulmonary emphysema: a family with three affected sibs. (3232707)
1988
40
Transcutaneous oxygen tension during exercise in patients with pulmonary emphysema. (3673786)
1987
41
Pulmonary interstitial emphysema in infants less than 1000 g at birth. (3767787)
1986
42
New approach to management of unilateral tension pulmonary interstitial emphysema in premature infants. (6472967)
1984
43
Lateral decubitus position as therapy for persistent focal pulmonary interstitial emphysema in neonates: a preliminary report. (6707799)
1984
44
Selective intubation in pulmonary interstitial emphysema: experience in five patients. (6529388)
1984
45
Biochemical links between cigarette smoking and pulmonary emphysema. (6352576)
1983
46
Surgical resection for pulmonary interstitial emphysema in the newborn infant. (702247)
1978
47
Pulmonary emphysema and alpha-1 antitrypsin deficiency. (303616)
1977
48
Selective bronchial intubation for the treatment of severe localized pulmonary interstitial emphysema in newborn infants. (908990)
1977
49
So-called bronchiolar emphysema. Its relatinhip to diffuse pulmonary fibrosis and pulmonary emphysema. (6059190)
1967
50
Hyperemesis gravidarum with pulmonary interstitial emphysema. (15415808)
1950

Genetic Variations for Pulmonary Emphysema

About this section

Expression for genes affiliated with Pulmonary Emphysema

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Emphysema

Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

About this section
Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
See all sources

Pathways related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ELN, ELANE
2
Hide members
10.4ELANE, MMP9
310.3SFTPD, SERPINA1, ELANE
410.3HMOX1, KEAP1
510.3HMOX1, MMP9, MMP1
610.3TIMP2, MMP9, HMOX1
710.3ELANE, MMP8, CTSG, SFTPD
8
Hide members
10.2MMP12, MMP8, CTSG, TIMP2
9
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.2TIMP2, MMP1, MMP9, ELANE, ELN
10
Hide members
10.2TIMP2, MMP8, MMP12, MMP1, MMP9
11
Cell adhesion ECM remodeling
Hide members
10.1ELN, MMP9, MMP1, MMP12, MMP8, TIMP2
12
Hide members
10.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
13
Hide members
10.1TIMP2, FGF23, MMP8, MMP12, MMP1, MMP9

Compounds for genes affiliated with Pulmonary Emphysema

About this section
Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8ELN
2(4-aminophenyl)mercuric acetate4410.8CTSG, MMP8, ELANE
3pge24410.8MMP9
4doxycycline44 1111.7MMP8, MMP1, ELANE
5egcg4410.7ELANE
6desmosine4410.7ELN, ELANE, SERPINA1
7cycloheximide4410.7CTSG, CRABP2, ELN
8thermolysin4410.7ELANE, CTSG, ELN, MMP1
9hocl4410.7SERPINA1, CTSG, MMP8, ELANE
10gi 254023x5910.6MMP8, MMP9, MMP1, MMP12
11uk 3833675910.6MMP1, MMP9, MMP12, MMP8
12gm 60015910.6MMP9, MMP1, MMP12, MMP8
13diisopropylfluorophosphate4410.6SERPINA1, CTSG, ELN, ELANE
14hydroxamate4410.6MMP8, TIMP2, MMP12, MMP1, MMP9
15marimastat44 59 1112.6MMP8, MMP9, MMP1, MMP12
16ilomastat4410.6ELANE, MMP1, MMP9
17batimastat44 59 1112.6MMP9, TIMP2, MMP8, MMP12, MMP1, ELANE
18hydroxyproline44 11 2412.5MMP9, MMP1, TIMP2, SLPI, ELN, SFTPD
19vitamin a44 11 2412.5ELANE, SERPINA1, MMP9, MMP1, CRABP2
20alendronate44 49 1112.5SLPI, MMP1, MMP8, TIMP2
21aprotinin44 1111.5SLPI, MMP9, MMP1, TIMP2, CTSG, ELANE
22cilomilast4410.5ELANE, MMP9, MMP1
23glycosaminoglycan4410.5MMP1, ELN, MMP9, SLPI, MMP8, TIMP2
24hyaluronic acid44 2411.5ELN, ELANE, SLPI, TIMP2, MMP9, MMP1
25sodium dodecylsulfate4410.5CRABP2, MMP1, ELN, CTSG, ELANE
26latanoprost44 1111.5TIMP2, MMP1, MMP9
27heparin44 28 11 2413.5SLPI, FGF23, ELANE, ELN, SERPINA1, CTSG
28serine4410.4TIMP2, CTSG, FGF23, MMP8, MMP12, MMP1
29genistein44 28 59 2 11 2415.4MMP12, MMP8, TIMP2, MMP9, SLPI, ELN
30creatinine4410.4MMP1, TIMP2, CTSG, FGF23, MMP9, SERPINA1
31superoxide44 2411.4HMOX1, SLPI, ELANE, GPX2, SERPINB1, MMP8
32ascorbic acid44 2411.4SERPINA1, SLPI, ELN, TIMP2, MMP1, HMOX1
33cyclosporin a44 28 5912.4ELANE, MMP8, TIMP2, SLPI, MMP1, MMP9
34fibrinogen4410.4CTSG, MMP12, MMP9, SLPI, ELANE, ELN
35carbon4410.4MMP1, ELN, HMOX1, ELANE, SFTPD
36hematoxylin4410.3MMP1, SLPI, ELN
37oxygen44 2411.3TIMP2, KEAP1, SLPI, ELANE, SERPINA1, MMP8
38lactate4410.3CTSG, SFTPD, TIMP2, MMP9, MMP8, MMP1
39nitric oxide44 11 2412.3HMOX1, SERPINA1, MMP8, TIMP2, SFTPD, CTSG
40vegf4410.3MMP8, SLPI, TIMP2, MMP12, MMP1, MMP9
41paraffin4410.2SERPINA1, MMP9, MMP1, CTSG, TIMP2, ELN
42h2o24410.2SERPINB1, MMP8, ELN, ELANE, SERPINA1, TIMP2
43actinomycin d4410.2MMP9, HMOX1, TIMP2, SLPI, ELN, CRABP2
44retinoic acid44 2411.2HMOX1, ELN, ELANE, TIMP2, CTSG, CRABP2
45cysteine4410.2ELN, ELANE, SFTPD, CTSG, HMOX1, KEAP1
46polyacrylamide4410.1SERPINA1, SLPI, CTSG, TIMP2, CRABP2
47proline4410.1FGF23, CTSG, CRABP2, ELN, MMP9, MMP8
48calcium44 49 11 2413.0CTSG, SLPI, TIMP2, SERPINB1, ELN, MMP9
49oligonucleotide449.9TIMP2, SFTPD, SERPINA1, MMP8, MMP12, MMP1
50dexamethasone44 49 28 1112.9MMP12, SFTPD, SLPI, MMP9

GO Terms for genes affiliated with Pulmonary Emphysema

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1MMP12, MMP1, MMP9, SERPINA1, ELN, MMP8
2extracellular regionGO:0055769.6ELN, TIMP2, SFTPD, CTSG, FGF23, MMP8
3extracellular spaceGO:0056159.5TIMP2, SFTPD, CTSG, FGF23, MMP8, MMP9

Biological processes related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.4ELANE, CTSG
2collagen catabolic processGO:03057410.2MMP8, MMP12, MMP1, MMP9, ELANE
3extracellular matrix disassemblyGO:02261710.2ELANE, TIMP2, CTSG, MMP8, MMP12, MMP1
4negative regulation of endopeptidase activityGO:01095110.2SLPI, SERPINA1, SERPINB1
5proteolysisGO:00650810.1CTSG, MMP8, MMP12, MMP1, MMP9, ELANE
6extracellular matrix organizationGO:03019810.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
7positive regulation of immune responseGO:05077810.1ELANE, CTSG

Molecular functions related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.3SERPINB1, SERPINA1, SLPI
2metalloendopeptidase activityGO:0042229.9MMP9, MMP1, MMP12, MMP8

Products for genes affiliated with Pulmonary Emphysema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Emphysema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet