MCID: PLM034
MIFTS: 57

Pulmonary Emphysema malady

Respiratory diseases category
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Summaries for Pulmonary Emphysema

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

MalaCards: Pulmonary Emphysema is related to bronchitis and cutis laxa. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are FOXA1 transcription factor network and Cell adhesion Cell matrix glycoconjugates. The drugs acetylcysteine and aminophylline and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Emphysema

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary emphysema 8 10 45 31 62


External Ids:

Disease Ontology8 DOID:9675
MeSH35 D011656
ICD9CM27 492.8

Related Diseases for Pulmonary Emphysema

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis30.8ELANE, SERPINA1
2cutis laxa30.7ELANE, ELN
3pulmonary fibrosis30.5ELN, ELANE, SFTPD
4lung cancer30.5MMP8, MMP12, SERPINA1, SFTPD
5asthma30.2SFTPD, SERPINA1, MMP12, MMP8, ELANE, CTSG
6periodontal disease30.2ELANE
7aneurysm30.2SERPINA1, MMP12, MMP8, ELANE, ELN
8respiratory failure30.1SFTPD, SERPINA1
9idiopathic pulmonary fibrosis30.1ELANE, SFTPD
10periodontitis30.1MMP8, ELANE
11extrinsic allergic alveolitis30.1CTSG, ELANE, SFTPD
12cystic fibrosis29.9SFTPD, SERPINA1, ELANE, ELN, CTSG
13atherosclerosis29.9MMP12, MMP8, ELANE, ELN, FGF23
14pneumonia29.9SFTPD, SERPINA1, MMP12, MMP8, ELANE, CTSG
15pulmonary function10.5
16alpha 1-antitrypsin deficiency10.4
17berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.4
18marfan syndrome10.3
19endotheliitis10.3
20interstitial emphysema10.3
21bronchiolitis10.2
22diffuse pulmonary fibrosis10.2
23hypertension10.2
24pneumothorax10.2
25tracheobronchomalacia10.2
26aspergillosis10.1ELANE, SFTPD
27emphysema due to aat deficiency10.1SERPINA1, ELANE
28adult respiratory distress syndrome10.1ELANE, SFTPD
29newborn respiratory distress syndrome10.1SFTPD, ELANE
30encephalomyelitis10.1MMP12
31ehlers-danlos syndrome10.1ELANE, ELN
32cerebral aneurysms10.1ELANE, ELN
33vascular disease10.1ELANE, ELN
34chorioamnionitis10.1MMP8, ELANE
35collagen disease10.1ELN, SFTPD
36primary sclerosing cholangitis10.0CTSG, ELANE
37connective tissue disease10.0ELN, SFTPD
38acute pancreatitis10.0ELANE, SERPINA1
39primary pulmonary hypertension10.0ELN, ELANE
40keloids10.0ELN, MMP8
41neurofibromatosis10.0
42neuroendocrine carcinoma10.0
43spontaneous tension pneumothorax10.0
44large cell neuroendocrine carcinoma10.0
45lymphangitis10.0
46cerebritis10.0
47substernal goiter10.0
48aortic aneurysm10.0
49bronchial disease10.0
50congenital heart disease10.0

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Symptoms for Pulmonary Emphysema

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Drugs & Therapeutics for Pulmonary Emphysema

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Emphysema

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

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Anatomical Context for Pulmonary Emphysema

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Emphysema:

33
Lung, Bone, Testes, Endothelial, Skeletal muscle, Placenta, Liver, Kidney, Colon, Heart, Bone marrow

Animal Models for Pulmonary Emphysema or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Emphysema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3SFTPD, MMP12, ELN, FGF23
2MP:00053977.6CTSG, ELANE, FGF23, MMP12, SFTPD
3MP:00053877.3MMP8, MMP12, ELANE, CTSG, FGF23, SFTPD

Publications for Pulmonary Emphysema

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Sources:
52PubMed
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Articles related to Pulmonary Emphysema:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Pulmonary Emphysema Subtypes on Computed Tomography: The MESA COPD Study. (24384106)
2014
2
Air leaks and pulmonary emphysema in infants: selective bronchial intubation or balloon occlusion? (23676528)
2013
3
Significant correlation between endothelial nitric oxide synthase (eNOS) expression and alveolar repair in elastase-induced rat pulmonary emphysema. (22911252)
2013
4
Baseline regional perfusion impacts exercise response to endobronchial valve therapy in advanced pulmonary emphysema. (23828481)
2013
5
Tidal Expiratory Flow Limitation at Rest as a Functional Marker of Pulmonary Emphysema in Moderate-to-Severe COPD. (24102405)
2013
6
Relationship between pulmonary emphysema and renal function in smokers. (23648928)
2013
7
Intravenous and Intratracheal Mesenchymal Stromal Cell Injection in a Mouse Model of Pulmonary Emphysema. (24295402)
2013
8
Ceramides: a potential therapeutic target in pulmonary emphysema. (24083966)
2013
9
Unfolding the mechanisms of progression of pulmonary emphysema in COPD. (23024322)
2012
10
Elastase-induced pulmonary emphysema: insights from experimental models. (22159348)
2011
11
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. (21706041)
2011
12
Pulmonary emphysema induced by cigarette smoke solution and lipopolysaccharide in guinea pigs. (19721232)
2009
13
Pulmonary emphysema: size distribution of emphysematous spaces on multidetector CT images--comparison with macroscopic and microscopic morphometry. (18710992)
2008
14
Texture-based quantification of pulmonary emphysema on high-resolution computed tomography: comparison with density-based quantification and correlation with pulmonary function test. (18496044)
2008
15
Morphological mechanism of the development of pulmonary emphysema in klotho mice. (17284608)
2007
16
The influence of pulmonary receptors on respiratory drive in a rabbit model of pulmonary emphysema. (16971190)
2007
17
Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification--comparison with macroscopic and microscopic morphometry. (17392257)
2007
18
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. (15944319)
2005
19
Induction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats. (15764723)
2005
20
Overexpression of placenta growth factor contributes to the pathogenesis of pulmonary emphysema. (14644931)
2004
21
A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. (15033705)
2003
22
Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. (14688706)
2003
23
Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. (11978916)
2002
24
Liquid ventilation in an infant with persistent interstitial pulmonary emphysema. (11344676)
2001
25
Cutis laxa and pulmonary emphysema. (18610669)
2001
26
Subjective symptoms and prognosis after lung volume reduction surgery in patients with severe pulmonary emphysema. (10554418)
1999
27
Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. (10084478)
1999
28
Surgical treatment for patients with lung cancer complicated by severe pulmonary emphysema. (10658374)
1999
29
Preferential binding of lysozyme to elastic fibres in pulmonary emphysema. (9659355)
1998
30
The usefulness of 99mTc-Technegas scintigraphy for diagnosing pulmonary impairment caused by pulmonary emphysema. (9588225)
1998
31
Macrophages in lung tissue from patients with pulmonary emphysema express both inducible and endothelial nitric oxide synthase. (9688186)
1998
32
Improvement in ejection fraction by hydrotherapy as rehabilitation in patients with chronic pulmonary emphysema. (9859136)
1998
33
Effect of lung volume reduction surgery on pulmonary hemodynamics in severe pulmonary emphysema. (9628374)
1998
34
Effect of pulmonary emphysema on diaphragm capillary geometry. (9049743)
1997
35
Quantitative assessment of the spatial distribution of low attenuation areas on X-ray CT using texture analysis in patients with chronic pulmonary emphysema. (9083798)
1997
36
HRCT evident fibrosis in isolated pulmonary emphysema. (9071310)
1997
37
Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. (9266901)
1997
38
Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema. (8815971)
1996
39
An automated method to assess the distribution of low attenuation areas on chest CT scans in chronic pulmonary emphysema patients. (7956377)
1994
40
Single breath N2 washout in papain-induced pulmonary emphysema. (2768646)
1989
41
Chest drains for pulmonary emphysema. (6135935)
1983
42
The deposition, distribution and retention of inhaled 239PuO2 in the lungs of rats with pulmonary emphysema. (6908591)
1981
43
Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. (7233186)
1981
44
Serum alpha 1 antitrypsin in pulmonary emphysema. (6976962)
1981
45
Pulmonary emphysema associated with the FZ alpha 1-antitrypsin phenotype. (6970613)
1981
46
Cadmium and pulmonary emphysema. (6103468)
1980
47
Prevalence, severity, and types of pulmonary emphysema in a population of deaths in a Finnish city. Correlation with age, sex and smoking. (684379)
1978
48
Acute bovine pulmonary emphysema produced by Perilla frutescens. (568714)
1978
49
IPPB in severe pulmonary emphysema: successful results. (799829)
1976
50
Progressive pulmonary emphysema associated with congenital generalized elastolysis (cutis laxa). (4428056)
1974

Variations for Pulmonary Emphysema

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Expression for genes affiliated with Pulmonary Emphysema

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Emphysema

Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Pulmonary Emphysema

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Sources:
45Novoseek, 3BitterDB, 61Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 51PharmGKB
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Compounds related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate4510.2SFTPD, ELANE
2sivelestat4510.1ELANE, SFTPD
3isodesmosine4510.0ELN, ELANE
4tannins459.9ELANE, ELN
5hydroxylysine459.9SFTPD, ELN
6elastatinal459.9ELANE, CTSG
74-nitroanilide459.9ELANE, CTSG
8saccharin45 310.9CTSG, ELANE
9chymostatin459.8CTSG, ELANE
10gi 254023x619.8MMP12, MMP8
11pmsf459.8ELANE, CTSG
12uk 383367619.8MMP8, MMP12
13epsilon aminocaproic acid459.8CTSG, ELANE
14gm 6001619.8MMP12, MMP8
15cacl2459.7ELN, MMP8
16hydroxamate459.7MMP8, MMP12
17marimastat45 61 1111.7MMP12, MMP8
18batimastat45 61 1111.6MMP8, MMP12, ELANE
19desmosine459.6ELN, SERPINA1, ELANE
20carbon459.6SFTPD, ELN, ELANE
21phosphonate459.5MMP8, CTSG
22doxycycline45 1110.5ELN, ELANE, MMP8
23endotoxin459.5CTSG, ELANE, SFTPD
24vitamin a45 24 1111.5ELN, SERPINA1, ELANE
25nh4cl459.4ELN, CTSG
26thermolysin459.4ELANE, ELN, CTSG
27phosphoramidon45 1110.4CTSG, ELANE
28sodium dodecylsulfate459.4CTSG, ELANE, ELN
29carbohydrates459.3ELN, SFTPD, CTSG
30oligonucleotide459.0MMP8, MMP12, SERPINA1, SFTPD
31phospholipid459.0SFTPD, CTSG, SERPINA1
32hocl459.0SERPINA1, CTSG, MMP8, ELANE
33diisopropylfluorophosphate459.0CTSG, ELN, ELANE, SERPINA1
34(4-aminophenyl)mercuric acetate458.9CTSG, ELN, ELANE, MMP8
35polysaccharide458.9SFTPD, SERPINA1, CTSG, ELN
36vitamin d458.9ELANE, FGF23, ELN
37oxygen45 249.8SERPINA1, MMP12, SFTPD, MMP8, ELANE
38lactate458.5SFTPD, MMP8, ELANE, ELN, CTSG
39nitric oxide45 24 1110.5SFTPD, CTSG, MMP8, MMP12, SERPINA1
40retinoic acid45 249.5ELN, ELANE, MMP8, CTSG
41lipid458.5SERPINA1, SFTPD, MMP12, MMP8, CTSG
42h2o2458.4CTSG, ELN, ELANE, MMP8, SERPINA1
43creatinine458.4CTSG, FGF23, ELN, SERPINA1
44proline458.4FGF23, CTSG, ELN, MMP8
45glucose458.2SFTPD, CTSG, SERPINA1, MMP8
46heparin45 29 24 1111.1FGF23, CTSG, ELN, ELANE, SERPINA1
47cysteine458.1ELN, ELANE, SFTPD, MMP8, SERPINA1, CTSG
48fibrinogen458.0SERPINA1, MMP12, MMP8, ELANE, ELN, CTSG
49calcium45 51 24 1110.6SFTPD, MMP12, ELN, CTSG, FGF23, MMP8
50serine456.8FGF23, ELN, ELANE, SFTPD, MMP12, CTSG

GO Terms for genes affiliated with Pulmonary Emphysema

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16Gene Ontology
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Cellular components related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5CTSG, ELANE
2proteinaceous extracellular matrixGO:0055788.5SERPINA1, MMP12, MMP8, ELN
3extracellular spaceGO:0056157.4FGF23, CTSG, MMP8, SERPINA1, SFTPD
4extracellular regionGO:0055766.4FGF23, SFTPD, SERPINA1, MMP12, MMP8, ELANE

Biological processes related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.8ELANE, SFTPD
2positive regulation of immune responseGO:0507789.6ELANE, CTSG
3negative regulation of growth of symbiont in hostGO:0441309.4CTSG, ELANE
4collagen catabolic processGO:0305749.3ELANE, MMP8, MMP12
5respiratory gaseous exchangeGO:0075859.3ELN, SFTPD
6response to lipopolysaccharideGO:0324969.1SERPINA1, ELANE, CTSG
7proteolysisGO:0065088.7CTSG, MMP12, MMP8, ELANE
8extracellular matrix disassemblyGO:0226178.3MMP12, MMP8, ELANE, ELN, CTSG
9extracellular matrix organizationGO:0301988.2CTSG, ELN, ELANE, MMP12, MMP8

Molecular functions related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:0041759.7ELANE, MMP12
2protease bindingGO:0020209.6ELANE, SERPINA1
3metalloendopeptidase activityGO:0042229.5MMP8, MMP12
4peptidase activityGO:0082339.2CTSG, ELANE
5serine-type endopeptidase activityGO:0042529.1MMP8, ELANE, CTSG

Products for genes affiliated with Pulmonary Emphysema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Emphysema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet