MCID: PLM034
MIFTS: 60

Pulmonary Emphysema malady

Summaries for Pulmonary Emphysema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

MalaCards: Pulmonary Emphysema is related to bronchitis and pulmonary fibrosis. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs acetylcysteine and aminophylline and the compounds estrogen and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Pulmonary Emphysema

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

pulmonary emphysema 8 10 44 30 60


External Ids:

Disease Ontology8 DOID:9675
MeSH34 D011656
ICD9CM27 492.8

Related Diseases for Pulmonary Emphysema

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis30.7SERPINA1
2pulmonary fibrosis30.6SFTPD, MMP1, MMP9, HMOX1, ELANE, ELN
3alpha 1-antitrypsin deficiency30.6SERPINA1, SERPINB1, ELANE
4lung cancer30.5TIMP2, SFTPD, KEAP1, MMP8, MMP12, MMP9
5asthma30.3SFTPD, CTSG, MMP8, MMP12, MMP9, SERPINA1
6hypertension30.2MMP9
7interstitial lung disease30.0SFTPD, MMP9
8extrinsic allergic alveolitis30.0ELANE, CTSG, SFTPD
9sarcoma30.0LYZ, SLPI
10idiopathic pulmonary fibrosis30.0SFTPD, MMP1, MMP9, ELANE
11periodontitis30.0TIMP2, MMP8, MMP1, MMP9, SLPI, ELANE
12cystic fibrosis30.0SFTPD, CTSG, HMOX1, SLPI, SERPINA1, ELANE
13periodontal disease30.0TIMP2, CTSG, MMP8, MMP1, MMP9, SLPI
14pneumonia30.0SFTPD, CTSG, MMP8, MMP12, HMOX1, SLPI
15atherosclerosis30.0TIMP2, FGF23, MMP8, MMP12, MMP1, MMP9
16respiratory failure30.0SERPINA1, SFTPD
17interstitial emphysema10.7
18cutis laxa10.3
19berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.3
20marfan syndrome10.3
21bronchiolitis10.1
22diffuse pulmonary fibrosis10.1
23bronchial disease10.1
24pneumothorax10.1
25substernal goiter10.0
26neurofibromatosis10.0
27spontaneous tension pneumothorax10.0
28neuroendocrine carcinoma10.0
29compensatory emphysema10.0
30ruptured thoracoabdominal aortic aneurysm10.0
31cerebritis10.0
32small cell carcinoma10.0
33lymphangitis10.0
34large cell carcinoma10.0
35osteoporosis10.0
36aortic aneurysm10.0
37goiter10.0
38hemolytic anemia10.0
39mediastinitis10.0
40neuromuscular disease10.0
41obstructive lung disease10.0
42papilledema10.0
43pulmonary large cell neuroendocrine carcinoma10.0
44ruptured aortic aneurysm10.0
45synovial sarcoma10.0
46fbln5-related cutis laxa10.0
47cutis laxa, autosomal recessive, type ia10.0
48bronchopulmonary dysplasia10.0ELANE
49galactosemia10.0SERPINA1
50abdominal aortic aneurysm10.0MMP9

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Clinical Features for Pulmonary Emphysema

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Drugs & Therapeutics for Pulmonary Emphysema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Emphysema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Emphysema

Search NIH Clinical Center for Pulmonary Emphysema

Search CenterWatch for Pulmonary Emphysema

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

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Anatomical Context for Pulmonary Emphysema

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Emphysema:

32
Lung, Bone, Testes, Endothelial, Skeletal muscle, Placenta, Colon, Heart, Bone marrow, Kidney, Liver, Fetal lung

Animal Models for Pulmonary Emphysema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Emphysema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1SFTPD, MMP9, SERPINB1, ELN
2MP:00053769.9FGF23, MMP12, GPX2, HMOX1, SLPI, SERPINB1
3MP:00053879.8ELANE, TIMP2, SFTPD, CTSG, FGF23, MMP8
4MP:00107689.6FGF23, CRABP2, KEAP1, CTSG, MMP9, GPX2
5MP:00053979.5TIMP2, SFTPD, CTSG, FGF23, MMP12, MMP9

Publications for Pulmonary Emphysema

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50PubMed
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Articles related to Pulmonary Emphysema:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Significant correlation between endothelial nitric oxide synthase (eNOS) expression and alveolar repair in elastase-induced rat pulmonary emphysema. (22911252)
2013
2
High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. (24060678)
2013
3
Increased incidence of autoimmune markers in patients with combined pulmonary fibrosis and emphysema. (23697753)
2013
4
Computed tomography biomarkers of pulmonary emphysema. (23875745)
2013
5
Prothymosin I+ overexpression contributes to the development of pulmonary emphysema. (23695700)
2013
6
Radiation pneumonitis in patients with lung and mediastinal tumours: a retrospective study of risk factors focused on pulmonary emphysema. (21385918)
2012
7
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. (21706041)
2011
8
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. (20007924)
2010
9
Incidence of tracheobronchomalacia associated with pulmonary emphysema: detection with paired inspiratory-expiratory multidetector computed tomography using a low-dose technique. (19856225)
2009
10
Volume correction in computed tomography densitometry for follow-up studies on pulmonary emphysema. (19056717)
2008
11
Computer-aided measurements of pulmonary emphysema in chest multidetector-row spiral computed tomography: effect of image reconstruction parameters. (19204452)
2008
12
HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema. (18723334)
2008
13
Sex differences in severe pulmonary emphysema. (17431226)
2007
14
Transbronchoscopic pulmonary emphysema treatment: 1-month to 24-month endoscopic follow-up. (16840401)
2006
15
CT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: are patients with pulmonary emphysema also candidates for SBRT for lung cancers? (16904838)
2006
16
Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. (14764579)
2004
17
Asymmetric evolution of pulmonary interstitial emphysema in a preterm newborn infant. (15310322)
2004
18
Pulmonary interstitial emphysema in a full-term infant: do we know the incidence? (16868387)
2003
19
Lung volume reduction surgery in a ventilated patient with severe pulmonary emphysema. (11269428)
2001
20
Comparison of changes in hemodynamics between unilateral and bilateral lung volume reduction for pulmonary emphysema. (11743852)
2001
21
Pathologic quiz case: patient with chronic obstructive pulmonary disease. Diffuse pulmonary neuroendocrine hyperplasia with multifocal tumorlets, immunoreactive to synaptophysin, associated with pulmonary emphysema. (10629157)
2000
22
Chest x-ray quiz. Pulmonary emphysema. (16948206)
2000
23
Pulmonary interstitial emphysema 24 hours after antenatal betamethasone treatment in preterm sheep. (10988135)
2000
24
Neonatal air leaks: pneumothorax, pneumomediastinum, pulmonary interstitial emphysema, pneumopericardium. (11885076)
1999
25
Surgical lung volume reduction for severe pulmonary emphysema--a new review series. (10232412)
1999
26
Unilateral pulmonary interstitial emphysema following pneumonia in a preterm infant successfully treated with prolonged selective bronchial intubation. (10614699)
1999
27
Influence of baseline airway calibre and pulmonary emphysema on bronchial responsiveness in patients with chronic obstructive pulmonary disease. (8759473)
1996
28
Pulmonary emphysema: quantitative CT during expiration. (8638012)
1996
29
Respiratory load compensation during hypercapnic ventilatory response in pulmonary emphysema. (8181326)
1994
30
CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings. (8140992)
1994
31
Unilateral pulmonary interstitial emphysema and treatment with colfosceril palmitate. (8099684)
1993
32
Pathogenesis and therapy of pulmonary emphysema. (8412525)
1993
33
Sequential morphologic changes of elastase-induced pulmonary emphysema in pig lungs. Evaluation by high-resolution computed tomography. (2055743)
1991
34
Influence of preexisting pulmonary emphysema on susceptibility of rats to inhaled diesel exhaust. (1692674)
1990
35
Molecular genetics in pulmonary emphysema. (3264478)
1988
36
Early pulmonary interstitial emphysema in the newborn: a grave prognostic sign. (3595042)
1987
37
Vascular and interstitial mechanics in canine pulmonary emphysema. (4077778)
1985
38
The role of nicotine in the pathogenesis of pulmonary emphysema. (6561015)
1984
39
Chest drains for pulmonary emphysema. (6135935)
1983
40
Computed tomography in pulmonary emphysema. (7083738)
1982
41
Effects of ipratropium bromide and fenoterol aerosols in pulmonary emphysema. (6218647)
1982
42
The deposition, distribution and retention of inhaled 239PuO2 in the lungs of rats with pulmonary emphysema. (6908591)
1981
43
Pulmonary emphysema associated with the FZ alpha 1-antitrypsin phenotype. (6970613)
1981
44
Cadmium and pulmonary emphysema. (6103468)
1980
45
Acute bovine pulmonary emphysema produced by Perilla frutescens. (568714)
1978
46
On defining microcardia: application in pulmonary emphysema. (622624)
1978
47
Chronic pulmonary disease in neonates after artificial ventilation: distribution of ventilation and pulmonary interstitial emphysema. (331223)
1977
48
Persistent interstitial pulmonary emphysema: another complication of the respiratory distress syndrome. (865937)
1977
49
Lobar emphysema, cystic adenomaloid malformation, pulmonary sequestration, and bronchogenic cyst in infancy and childhood: A clinical group. (4811257)
1974
50
OBSERVATIONS ON THE PULMONARY VASCULATURE IN A CASE OF CENTRILOBULAR EMPHYSEMA WITH HEMOSIDEROSIS. (14059465)
1963

Genetic Variations for Pulmonary Emphysema

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Expression for genes affiliated with Pulmonary Emphysema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Emphysema

Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ELN, ELANE
2
Hide members
10.4ELANE, MMP9
310.3SFTPD, SERPINA1, ELANE
410.3HMOX1, KEAP1
510.3HMOX1, MMP9, MMP1
610.3TIMP2, MMP9, HMOX1
710.3ELANE, MMP8, CTSG, SFTPD
8
Hide members
10.2MMP12, MMP8, CTSG, TIMP2
9
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.2TIMP2, MMP1, MMP9, ELANE, ELN
10
Hide members
10.2TIMP2, MMP8, MMP12, MMP1, MMP9
11
Cell adhesion ECM remodeling
Hide members
10.1ELN, MMP9, MMP1, MMP12, MMP8, TIMP2
12
Hide members
10.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
13
Hide members
10.1TIMP2, FGF23, MMP8, MMP12, MMP1, MMP9

Compounds for genes affiliated with Pulmonary Emphysema

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8ELN
2(4-aminophenyl)mercuric acetate4410.8CTSG, MMP8, ELANE
3pge24410.8MMP9
4doxycycline44 1111.7MMP8, MMP1, ELANE
5egcg4410.7ELANE
6desmosine4410.7ELN, ELANE, SERPINA1
7cycloheximide4410.7CTSG, CRABP2, ELN
8thermolysin4410.7ELANE, CTSG, ELN, MMP1
9hocl4410.7SERPINA1, CTSG, MMP8, ELANE
10gi 254023x5910.6MMP8, MMP9, MMP1, MMP12
11uk 3833675910.6MMP1, MMP9, MMP12, MMP8
12gm 60015910.6MMP9, MMP1, MMP12, MMP8
13diisopropylfluorophosphate4410.6SERPINA1, CTSG, ELN, ELANE
14hydroxamate4410.6MMP8, TIMP2, MMP12, MMP1, MMP9
15marimastat44 59 1112.6MMP8, MMP9, MMP1, MMP12
16ilomastat4410.6ELANE, MMP1, MMP9
17batimastat44 59 1112.6MMP9, TIMP2, MMP8, MMP12, MMP1, ELANE
18hydroxyproline44 11 2412.5MMP9, MMP1, TIMP2, SLPI, ELN, SFTPD
19vitamin a44 11 2412.5ELANE, SERPINA1, MMP9, MMP1, CRABP2
20alendronate44 49 1112.5SLPI, MMP1, MMP8, TIMP2
21aprotinin44 1111.5SLPI, MMP9, MMP1, TIMP2, CTSG, ELANE
22cilomilast4410.5ELANE, MMP9, MMP1
23glycosaminoglycan4410.5MMP1, ELN, MMP9, SLPI, MMP8, TIMP2
24hyaluronic acid44 2411.5ELN, ELANE, SLPI, TIMP2, MMP9, MMP1
25sodium dodecylsulfate4410.5CRABP2, MMP1, ELN, CTSG, ELANE
26latanoprost44 1111.5TIMP2, MMP1, MMP9
27heparin44 28 11 2413.5SLPI, FGF23, ELANE, ELN, SERPINA1, CTSG
28serine4410.4TIMP2, CTSG, FGF23, MMP8, MMP12, MMP1
29genistein44 28 59 2 11 2415.4MMP12, MMP8, TIMP2, MMP9, SLPI, ELN
30creatinine4410.4MMP1, TIMP2, CTSG, FGF23, MMP9, SERPINA1
31superoxide44 2411.4HMOX1, SLPI, ELANE, GPX2, SERPINB1, MMP8
32ascorbic acid44 2411.4SERPINA1, SLPI, ELN, TIMP2, MMP1, HMOX1
33cyclosporin a44 28 5912.4ELANE, MMP8, TIMP2, SLPI, MMP1, MMP9
34fibrinogen4410.4CTSG, MMP12, MMP9, SLPI, ELANE, ELN
35carbon4410.4MMP1, ELN, HMOX1, ELANE, SFTPD
36hematoxylin4410.3MMP1, SLPI, ELN
37oxygen44 2411.3TIMP2, KEAP1, SLPI, ELANE, SERPINA1, MMP8
38lactate4410.3CTSG, SFTPD, TIMP2, MMP9, MMP8, MMP1
39nitric oxide44 11 2412.3HMOX1, SERPINA1, MMP8, TIMP2, SFTPD, CTSG
40vegf4410.3MMP8, SLPI, TIMP2, MMP12, MMP1, MMP9
41paraffin4410.2SERPINA1, MMP9, MMP1, CTSG, TIMP2, ELN
42h2o24410.2SERPINB1, MMP8, ELN, ELANE, SERPINA1, TIMP2
43actinomycin d4410.2MMP9, HMOX1, TIMP2, SLPI, ELN, CRABP2
44retinoic acid44 2411.2HMOX1, ELN, ELANE, TIMP2, CTSG, CRABP2
45cysteine4410.2ELN, ELANE, SFTPD, CTSG, HMOX1, KEAP1
46polyacrylamide4410.1SERPINA1, SLPI, CTSG, TIMP2, CRABP2
47proline4410.1FGF23, CTSG, CRABP2, ELN, MMP9, MMP8
48calcium44 49 11 2413.0CTSG, SLPI, TIMP2, SERPINB1, ELN, MMP9
49oligonucleotide449.9TIMP2, SFTPD, SERPINA1, MMP8, MMP12, MMP1
50dexamethasone44 49 28 1112.9MMP12, SFTPD, SLPI, MMP9

GO Terms for genes affiliated with Pulmonary Emphysema

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16Gene Ontology
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Cellular components related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1MMP8, MMP12, MMP1, MMP9, ELN, SERPINA1
2extracellular regionGO:0055769.6ELN, TIMP2, SFTPD, CTSG, FGF23, MMP8
3extracellular spaceGO:0056159.5HMOX1, MMP9, MMP8, FGF23, CTSG, SFTPD

Biological processes related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.4ELANE, CTSG
2collagen catabolic processGO:03057410.2MMP8, MMP12, MMP1, MMP9, ELANE
3extracellular matrix disassemblyGO:02261710.2ELANE, TIMP2, CTSG, MMP8, MMP12, MMP1
4negative regulation of endopeptidase activityGO:01095110.2SLPI, SERPINA1, SERPINB1
5proteolysisGO:00650810.1CTSG, MMP8, MMP12, MMP1, MMP9, ELANE
6extracellular matrix organizationGO:03019810.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
7positive regulation of immune responseGO:05077810.1ELANE, CTSG

Molecular functions related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.3SERPINB1, SERPINA1, SLPI
2metalloendopeptidase activityGO:0042229.9MMP9, MMP1, MMP12, MMP8

Products for genes affiliated with Pulmonary Emphysema

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  • Antibodies
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Sources for Pulmonary Emphysema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet