MCID: PLM034
MIFTS: 53

Pulmonary Emphysema malady

Summaries for Pulmonary Emphysema

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

MalaCards: Pulmonary Emphysema is related to bronchitis and pulmonary disease, chronic obstructive. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. The drugs acetylcysteine and aminophylline and the compounds estrogen and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Pulmonary Emphysema

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

pulmonary emphysema 8 10 45 31 61


External Ids:

Disease Ontology8 DOID:9675
MeSH35 D011656
ICD9CM27 492.8

Related Diseases for Pulmonary Emphysema

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis30.7SERPINA1
2pulmonary disease, chronic obstructive30.6SERPINA1, HMOX1
3asthma30.4ELANE, SFTPD, CTSG, MMP8, MMP12, SERPINA1
4alpha 1-antitrypsin deficiency30.2SERPINB1, ELANE, SERPINA1
5cerebral aneurysms30.0ELN, TIMP2, ELANE
6idiopathic pulmonary fibrosis30.0MMP1, SFTPD, ELANE, MMP9
7cystic fibrosis30.0SERPINA1, SLPI, HMOX1, CTSG, SFTPD, ELN
8atherosclerosis30.0FGF23, TIMP2, MMP12, MMP1, MMP8, HMOX1
9pulmonary function10.8
10interstitial emphysema10.7
11cutis laxa10.4
12berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.4
13marfan syndrome10.3
14n syndrome10.3
15diffuse pulmonary fibrosis10.2
16tracheobronchomalacia10.2
17spontaneous pneumothorax10.2
18substernal goiter10.0
19neurofibromatosis10.0
20spontaneous tension pneumothorax10.0
21neuroendocrine carcinoma10.0
22compensatory emphysema10.0
23small cell carcinoma10.0
24lymphangitis10.0
25large cell carcinoma10.0
26osteoporosis10.0
27aortic aneurysm10.0
28synovial sarcoma10.0
29efemp2-related cutis laxa10.0
30fbln5-related cutis laxa10.0
31bronchogenic cyst10.0
32salla disease10.0
33neonatal marfan syndrome10.0
34bronchopulmonary dysplasia10.0ELANE
35galactosemia10.0SERPINA1
36abdominal aortic aneurysm10.0MMP9
37hepatitis10.0SERPINA1
38hepatitis c10.0SERPINA1
39crohn's disease10.0LYZ
40coronary heart disease10.0MMP8
41pancreatitis10.0SERPINA1, ELANE
42ischemia10.0HMOX1
43encephalomyelitis10.0MMP12
44kawasaki disease10.0ELANE, MMP9
45chorioamnionitis10.0ELANE, MMP8
46hypertensive heart disease10.0MMP1
47sarcoidosis10.0SFTPD, LYZ
48hepatopulmonary syndrome10.0HMOX1
49liver cirrhosis10.0SERPINA1, SLPI
50myeloma10.0MMP8

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Clinical Features for Pulmonary Emphysema

Drugs & Therapeutics for Pulmonary Emphysema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Emphysema

Drug clinical trials:

Search ClinicalTrials for Pulmonary Emphysema

Search NIH Clinical Center for Pulmonary Emphysema

Search CenterWatch for Pulmonary Emphysema

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

Anatomical Context for Pulmonary Emphysema

Animal Models for Pulmonary Emphysema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pulmonary Emphysema

Sources:
51PubMed
See all sources

Articles related to Pulmonary Emphysema:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Intravenous and Intratracheal Mesenchymal Stromal Cell Injection in a Mouse Model of Pulmonary Emphysema. (24295402)
2013
2
Ceramides: a potential therapeutic target in pulmonary emphysema. (24083966)
2013
3
Computed tomography density histogram analysis to evaluate pulmonary emphysema in ex-smokers. (23570935)
2013
4
Emphysema in asymptomatic smokers: quantitative CT evaluation in correlation with pulmonary function tests. (23601360)
2013
5
Severe Pulmonary Interstitial Emphysema in a Premature Baby. (24113884)
2013
6
Relationship between quantitative CT metrics and pulmonary function in combined pulmonary fibrosis and emphysema. (24085320)
2013
7
Vertical P-wave axis: the electrocardiographic synonym for pulmonary emphysema and its severity. (22572424)
2012
8
Three-dimensional airway lumen volumetry: comparison with bronchial wall area and parenchymal densitometry in assessment of airway obstruction in pulmonary emphysema. (22932062)
2012
9
Single-lung transplantation in a chronic pulmonary emphysema patient with a marginal donor who was ABO blood group nonidentical but compatible. (22453544)
2012
10
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD. (20106877)
2010
11
Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial. (18690451)
2009
12
Airway malacia in chronic obstructive pulmonary disease: prevalence, morphology and relationship with emphysema, bronchiectasis and bronchial wall thickening. (19205703)
2009
13
Pulmonary lobar interstitial emphysema. (19842871)
2009
14
Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice. (17766584)
2007
15
Localized persistent pulmonary interstitial emphysema. (16769360)
2006
16
Peripheral solitary pulmonary nodule: CT findings in patients with pulmonary emphysema. (15716392)
2005
17
Localized persistent pulmonary interstitial emphysema in a preterm infant in the absence of mechanical ventilation. (16086158)
2005
18
How a test for elastic fiber breakdown products in sputum could speed development of a treatment for pulmonary emphysema. (14704646)
2004
19
Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. (14706858)
2004
20
CT findings and temporal course of persistent pulmonary interstitial emphysema in neonates: a multiinstitutional study. (12646469)
2003
21
CT quantification of pulmonary emphysema: assessment of lung structure and function. (12521149)
2002
22
Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema. (11716178)
2001
23
Delayed presentation of pulmonary interstitial emphysema. (10826078)
2000
24
Pathological case of the month. Persistent interstitial pulmonary emphysema presenting as a large unilocular cyst in an asymptomatic infant. (10632259)
2000
25
Surgical treatment for patients with lung cancer complicated by severe pulmonary emphysema. (10658374)
1999
26
Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. (10486094)
1999
27
Preferential binding of lysozyme to elastic fibres in pulmonary emphysema. (9659355)
1998
28
The usefulness of 99mTc-Technegas scintigraphy for diagnosing pulmonary impairment caused by pulmonary emphysema. (9588225)
1998
29
HRCT evident fibrosis in isolated pulmonary emphysema. (9071310)
1997
30
Combined thoracoscopic lung resection and laser ablation for lung cancer with pulmonary emphysema: report of a case. (9035304)
1997
31
Video-assisted thoracoscopic volume reduction surgery in patients with diffuse pulmonary emphysema: gas exchange and anesthesiological management. (9085969)
1997
32
Thoracoscopic bilateral lung volume reduction for diffuse pulmonary emphysema. (9237579)
1997
33
The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. (7952650)
1994
34
Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. (1458541)
1992
35
Respiratory muscle strength and gas exchange in neuromuscular diseases: comparison with chronic pulmonary emphysema and idiopathic pulmonary fibrosis. (2815076)
1989
36
Large-image intensifier photofluorography and conventional radiography in pulmonary emphysema. Correlation with computed tomography. (2968097)
1988
37
Pulmonary crepitations: a clue in the diagnosis of pulmonary interstitial emphysema? (3197740)
1988
38
Persistent interstitial pulmonary emphysema. (3463313)
1986
39
Lesions in resected lung parenchyma with regard to possible initial phase of pulmonary emphysema. An ultrastructural study. (3703741)
1986
40
Investigations into the biochemical mechanisms of pulmonary emphysema: effects of cigarette smoke on enzymes and anti-enzymes in the lung. (3544109)
1986
41
Pulmonary interstitial emphysema in the adult respiratory distress syndrome. (3896647)
1985
42
Pulmonary emphysema and the crossover point. (6494623)
1984
43
Errors in the estimation of vital capacity from expiratory flow-volume curves in pulmonary emphysema. (7126441)
1982
44
Unilateral pulmonary interstitial emphysema: a surgical approach to treatment. (7033910)
1981
45
Impaired angiotensin conversion and bradykinin clearance in experimental canine pulmonary emphysema. (6256412)
1981
46
An autopsy case of large pulmonary bulla with senile emphysema and the indication of surgery to senile pulmonary emphysema. (7437931)
1980
47
Pulmonary interstitial emphysema requiring lobectomy. Complications of assisted ventilation. (352276)
1978
48
The lung of the copper-deficient rat. A model for developmental pulmonary emphysema. (207187)
1978
49
Unilateral pulmonary interstitial emphysema. (978347)
1976
50
Pulmonary interstitial emphysema. (13093975)
1953

Genetic Variations for Pulmonary Emphysema

Expression for genes affiliated with Pulmonary Emphysema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Emphysema

Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ELN, ELANE
2
Hide members
10.4ELANE, MMP9
310.3SFTPD, SERPINA1, ELANE
410.3HMOX1, KEAP1
510.3HMOX1, MMP9, MMP1
610.3TIMP2, MMP9, HMOX1
710.3ELANE, MMP8, CTSG, SFTPD
8
Hide members
10.2MMP12, MMP8, CTSG, TIMP2
9
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.2TIMP2, MMP1, MMP9, ELANE, ELN
10
Hide members
10.2TIMP2, MMP8, MMP12, MMP1, MMP9
11
Cell adhesion ECM remodeling
Hide members
10.1ELN, MMP9, MMP1, MMP12, MMP8, TIMP2
12
Hide members
10.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
13
Hide members
10.1TIMP2, FGF23, MMP8, MMP12, MMP1, MMP9

Compounds for genes affiliated with Pulmonary Emphysema

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8ELN
2(4-aminophenyl)mercuric acetate4510.8CTSG, MMP8, ELANE
3pge24510.8MMP9
4doxycycline45 1111.7MMP8, MMP1, ELANE
5egcg4510.7ELANE
6desmosine4510.7ELN, ELANE, SERPINA1
7cycloheximide4510.7CTSG, CRABP2, ELN
8thermolysin4510.7ELANE, CTSG, ELN, MMP1
9hocl4510.7SERPINA1, CTSG, MMP8, ELANE
10gi 254023x6010.6MMP8, MMP9, MMP1, MMP12
11uk 3833676010.6MMP1, MMP9, MMP12, MMP8
12gm 60016010.6MMP9, MMP1, MMP12, MMP8
13diisopropylfluorophosphate4510.6SERPINA1, CTSG, ELN, ELANE
14hydroxamate4510.6MMP8, TIMP2, MMP12, MMP1, MMP9
15marimastat45 60 1112.6MMP8, MMP9, MMP1, MMP12
16ilomastat4510.6ELANE, MMP1, MMP9
17batimastat45 60 1112.6MMP9, TIMP2, MMP8, MMP12, MMP1, ELANE
18hydroxyproline45 11 2412.5MMP9, MMP1, TIMP2, SLPI, ELN, SFTPD
19vitamin a45 11 2412.5ELANE, SERPINA1, MMP9, MMP1, CRABP2
20alendronate45 50 1112.5SLPI, MMP1, MMP8, TIMP2
21aprotinin45 1111.5SLPI, MMP9, MMP1, TIMP2, CTSG, ELANE
22cilomilast4510.5ELANE, MMP9, MMP1
23glycosaminoglycan4510.5MMP1, ELN, MMP9, SLPI, MMP8, TIMP2
24hyaluronic acid45 2411.5ELN, ELANE, SLPI, TIMP2, MMP9, MMP1
25sodium dodecylsulfate4510.5CRABP2, MMP1, ELN, CTSG, ELANE
26latanoprost45 1111.5TIMP2, MMP1, MMP9
27heparin45 29 11 2413.5SLPI, FGF23, ELANE, ELN, SERPINA1, CTSG
28serine4510.4TIMP2, CTSG, FGF23, MMP8, MMP12, MMP1
29genistein45 29 60 2 11 2415.4MMP12, MMP8, TIMP2, MMP9, SLPI, ELN
30creatinine4510.4MMP1, TIMP2, CTSG, FGF23, MMP9, SERPINA1
31superoxide45 2411.4HMOX1, SLPI, ELANE, GPX2, SERPINB1, MMP8
32ascorbic acid45 2411.4SERPINA1, SLPI, ELN, TIMP2, MMP1, HMOX1
33cyclosporin a45 29 6012.4ELANE, MMP8, TIMP2, SLPI, MMP1, MMP9
34fibrinogen4510.4CTSG, MMP12, MMP9, SLPI, ELANE, ELN
35carbon4510.4MMP1, ELN, HMOX1, ELANE, SFTPD
36hematoxylin4510.3MMP1, SLPI, ELN
37oxygen45 2411.3TIMP2, KEAP1, SLPI, ELANE, SERPINA1, MMP8
38lactate4510.3CTSG, SFTPD, TIMP2, MMP9, MMP8, MMP1
39nitric oxide45 11 2412.3HMOX1, SERPINA1, MMP8, TIMP2, SFTPD, CTSG
40vegf4510.3MMP8, SLPI, TIMP2, MMP12, MMP1, MMP9
41paraffin4510.2SERPINA1, MMP9, MMP1, CTSG, TIMP2, ELN
42h2o24510.2SERPINB1, MMP8, ELN, ELANE, SERPINA1, TIMP2
43actinomycin d4510.2MMP9, HMOX1, TIMP2, SLPI, ELN, CRABP2
44retinoic acid45 2411.2HMOX1, ELN, ELANE, TIMP2, CTSG, CRABP2
45cysteine4510.2ELN, ELANE, SFTPD, CTSG, HMOX1, KEAP1
46polyacrylamide4510.1SERPINA1, SLPI, CTSG, TIMP2, CRABP2
47proline4510.1FGF23, CTSG, CRABP2, ELN, MMP9, MMP8
48calcium45 50 11 2413.0CTSG, SLPI, TIMP2, SERPINB1, ELN, MMP9
49oligonucleotide459.9TIMP2, SFTPD, SERPINA1, MMP8, MMP12, MMP1
50dexamethasone45 50 29 1112.9MMP12, SFTPD, SLPI, MMP9

GO Terms for genes affiliated with Pulmonary Emphysema

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1MMP8, MMP12, MMP1, MMP9, ELN, SERPINA1
2extracellular regionGO:0055769.6ELN, TIMP2, SFTPD, CTSG, FGF23, MMP8
3extracellular spaceGO:0056159.5HMOX1, MMP9, MMP8, FGF23, CTSG, SFTPD

Biological processes related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.4ELANE, CTSG
2collagen catabolic processGO:03057410.2MMP8, MMP12, MMP1, MMP9, ELANE
3extracellular matrix disassemblyGO:02261710.2ELANE, TIMP2, CTSG, MMP8, MMP12, MMP1
4negative regulation of endopeptidase activityGO:01095110.2SLPI, SERPINA1, SERPINB1
5proteolysisGO:00650810.1CTSG, MMP8, MMP12, MMP1, MMP9, ELANE
6extracellular matrix organizationGO:03019810.1TIMP2, CTSG, MMP8, MMP12, MMP1, MMP9
7positive regulation of immune responseGO:05077810.1ELANE, CTSG

Molecular functions related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.3SERPINB1, SERPINA1, SLPI
2metalloendopeptidase activityGO:0042229.9MMP9, MMP1, MMP12, MMP8

Products for genes affiliated with Pulmonary Emphysema

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Emphysema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet