Aliases & Classifications for Pulmonary Emphysema

MalaCards integrated aliases for Pulmonary Emphysema:

Name: Pulmonary Emphysema 38 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9675
ICD10 33 J43.8
ICD9CM 35 492.8
UMLS 69 C0029607

Summaries for Pulmonary Emphysema

MalaCards based summary : Pulmonary Emphysema is related to berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification and alpha 1-antitrypsin deficiency, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Pulmonary Emphysema is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Simvastatin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Pulmonary Emphysema

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification 11.9
2 alpha 1-antitrypsin deficiency 11.3
3 cutis laxa, autosomal recessive type 1 10.9
4 chronic orthostatic intolerance 10.7 ELANE ELN
5 tinea profunda 10.7 ELN MMP9
6 kleptomania 10.7 MMP1 MMP9
7 bullous pemphigoid 10.7 ELANE SERPINB1
8 alcoholic pancreatitis 10.6 ELANE ELN
9 childhood endodermal sinus tumor 10.6 MMP9 TIMP2
10 tetanus 10.6 ELANE ELN
11 xanthogranulomatous cholecystitis 10.6 MMP1 MMP9
12 early myoclonic encephalopathy 10.6 MMP1 MMP9
13 common variable immunodeficiency 10.6 MMP9 TIMP1
14 ectropion 10.6 MMP1 MMP9
15 anal fistula 10.5 ELANE ELN SERPINA1
16 immunodeficiency 27b, mycobacteriosis, ad 10.5 MMP9 TIMP1
17 arteriosclerosis 10.5 ELANE SERPINA1
18 hemoglobin lepore-beta-thalassemia syndrome 10.5 ELN MMP1 MMP9
19 cecum adenoma 10.5 MMP9 TIMP1
20 follicular mucinosis 10.5 ELANE MMP9
21 nasal cavity carcinoma in situ 10.4 ELANE SERPINA1 SERPINB1
22 tuberculous salpingitis 10.4 MMP9 TIMP1
23 chickenpox 10.4 ELANE SERPINA1 SERPINB1
24 lipoic acid synthetase deficiency 10.4 MMP1 TIMP2
25 breast adenomyoepithelioma 10.4 ELANE MMP9 TIMP1
26 amelogenesis imperfecta hypomaturation type 10.4 MMP8 MMP9
27 adenosine monophosphate deaminase 1 deficiency 10.4 MMP1 MMP9 TIMP2
28 diamond-blackfan anemia 1 10.3 ELANE MMP9 TIMP1
29 oligomeganephronic renal hypoplasia 10.3 MMP1 MMP9
30 spinal cord intramedullary teratoma 10.3 ELN MMP9 TIMP1
31 spindle epithelial tumor with thymus-like differentiation tumor 10.3 MMP9 TIMP1 TIMP2
32 ulnar neuropathy 10.3 MMP9 TIMP1 TIMP2
33 congenital chloride diarrhea 10.3 MMP1 MMP8
34 colon squamous cell carcinoma 10.3 MMP9 TIMP1 TIMP2
35 limbic encephalitis 10.3 MMP1 MMP12 MMP9
36 optic atrophy 7 10.2 MMP1 MMP8
37 macroglobulinemia, waldenstrom 1 10.2 ELANE ELN SERPINA1 SERPINB1
38 gait apraxia 10.2 MMP1 TIMP1 TIMP2
39 mycobacterium kansasii 10.2 HMOX1 SERPINA1
40 cystitis 10.2 HMOX1 MMP9 SERPINA1
41 lower clivus meningioma 10.2 MMP8 MMP9
42 myelophthisic anemia 10.2 ELN HMOX1 MMP9
43 sex differentiation disease 10.2 SERPINA1 TIMP1
44 tricuspid valve prolapse 10.2 SERPINA1 TIMP1
45 neonatal period electroclinical syndrome 10.1 ELANE MMP8 MMP9
46 germ cell and embryonal cancer 10.1 ELANE MMP8 MMP9
47 venezuelan equine encephalitis 10.1 ELANE MMP8 SERPINA1
48 skin amelanotic melanoma 10.1 HMOX1 MMP1 TIMP2
49 lung papillary adenocarcinoma 10.1 MMP9 TIMP1
50 lung cancer 10.1

Comorbidity relations with Pulmonary Emphysema via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to Pulmonary Emphysema

Symptoms & Phenotypes for Pulmonary Emphysema

UMLS symptoms related to Pulmonary Emphysema:


coughing, hemoptysis, snoring

MGI Mouse Phenotypes related to Pulmonary Emphysema:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ELANE HMOX1 ITGB6 MMP1 MMP12 MMP8
2 hematopoietic system MP:0005397 9.91 ITGB6 MMP12 MMP9 SERPINB1 SFTPD TIMP1
3 immune system MP:0005387 9.7 MMP12 MMP8 MMP9 SERPINB1 SFTPD TIMP1
4 respiratory system MP:0005388 9.23 HMOX1 ITGB6 MMP12 MMP9 SERPINB1 SESN2

Drugs & Therapeutics for Pulmonary Emphysema

Drugs for Pulmonary Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 257)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Budesonide Approved Phase 4,Phase 3 51333-22-3 63006 5281004
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
6
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
7
Losartan Approved Phase 4 114798-26-4 3961
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
9
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
12 tannic acid Approved, Nutraceutical Phase 4
13
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
14
Lactitol Investigational Phase 4 585-86-4 3871
15 Anesthetics Phase 4,Phase 2,Phase 1
16 Anticholesteremic Agents Phase 4
17 Antimetabolites Phase 4,Phase 1
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
19 Hypolipidemic Agents Phase 4,Phase 1
20 Lipid Regulating Agents Phase 4,Phase 1
21 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
22 Anti-Infective Agents Phase 4,Phase 1
23 Antimalarials Phase 4
24 Antiparasitic Agents Phase 4
25 Antiprotozoal Agents Phase 4
26 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
29 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
30 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33
Beclomethasone Phase 4,Phase 3 4419-39-0 20469
34 Bromides Phase 4,Phase 3,Phase 2
35 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 Cholinergic Agents Phase 4,Phase 2
37 Cholinergic Antagonists Phase 4,Phase 2
38 Formoterol Fumarate Phase 4,Phase 3,Phase 2
39 glucocorticoids Phase 4,Phase 3,Phase 1
40 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Parasympatholytics Phase 4,Phase 2
45 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Respiratory System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
47 Tiotropium Bromide Phase 4,Phase 2 136310-93-5
48 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
49
Salmeterol xinafoate Phase 4,Phase 3 94749-08-3 56801
50 Alpha 1-Antitrypsin Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 473)

id Name Status NCT ID Phase Drugs
1 AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation Unknown status NCT01460108 Phase 4
2 EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema Unknown status NCT00730301 Phase 4
3 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype Unknown status NCT01431625 Phase 4
4 Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
5 Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00857038 Phase 4 Doxycycline;Placebo
6 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4 Tiotropium + formoterol/beclometasone;tiotropium + placebo
7 Airway Clearance for Prevention of COPD Exacerbation Unknown status NCT00181207 Phase 4
8 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
9 Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography Unknown status NCT01361984 Phase 4 Nebulized arformoterol;Salmeterol
10 Small Airways Evaluation and Treatment Unknown status NCT02526758 Phase 4 beclomethasone;formoterol;budesonide
11 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
12 Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema Completed NCT00570544 Phase 4 tiotropium
13 Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency Completed NCT00261833 Phase 4
14 Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. Completed NCT00670007 Phase 4
15 Efficacy Study of the Effect of Budesonide on Emphysema Completed NCT00232674 Phase 4 Pulmicort (budesonide) Turbuhaler
16 Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients Completed NCT01336283 Phase 4
17 Efficacy of Losartan in Preventing Progression of COPD Completed NCT00720226 Phase 4 Losartan;Placebo
18 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00424528 Phase 4 Arformoterol Tartrate Inhalation Solution;Tiotropium;Arformoterol and Tiotropium;Placebo
19 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients Completed NCT00680056 Phase 4 Formoterol plus Placebo (Tiotropium);Formoterol plus Tiotropium
20 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis Completed NCT03073798 Phase 4 Roflumilast;Placebo
21 Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study Completed NCT01110200 Phase 4 ADVAIR DISKUS 250/50 mg BID;SEREVENT 50 mcg BID
22 Inhaled Steroid Reduces Systemic Inflammation in COPD Completed NCT00175565 Phase 4 inhaled fluticasone 500 mcg b.i.d.
23 Change of Inspiratory Peak Flow in COPD Completed NCT00561886 Phase 4 Formoterol
24 Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients Completed NCT02181023 Phase 4 Aclidinium Bromide;Glycopyrronium Bromide
25 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
26 Dynamic Hyperinflation and Tiotropium Completed NCT00569270 Phase 4 tiotropium;placebo;tiotropium
27 An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease Completed NCT00974805 Phase 4 Seretide 500 Accuhaler
28 Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD Completed NCT00571428 Phase 4 Arformoterol Tartrate Inhalation Solution;Arformoterol Tartrate Inhalation Solution;Placebo
29 Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD Completed NCT01745848 Phase 4 Roflumilast
30 A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00857766 Phase 4 ADVAIR DISKUS™ 250/50mcg
31 Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD Completed NCT02209974 Phase 4 Fluticasone;Inhaled Placebo
32 Study of the Effect of the ROX AC1 on Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease (COPD) Patients Completed NCT00832611 Phase 4
33 Costs & Outcomes of Hospitalization/Treatment With Levalbuterol & Albuterol in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Subjects Completed NCT00667797 Phase 4 levalbuterol HCl;albuterol Sulfate
34 Altitude Related Illness In Patients With Respiratory Disease Completed NCT02450968 Phase 4 Dexamethasone;Placebo
35 Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD Completed NCT01693003 Phase 4 Indacaterol;Tiotropium
36 Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude Completed NCT02450994 Phase 4 Dexamethasone;Placebo
37 Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00202189 Phase 4 Budesonide
38 GLASSIA Infusion Rate Study Completed NCT01651351 Phase 4
39 Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) Completed NCT00396006 Phase 4
40 Losartan Effects on Emphysema Progression Recruiting NCT02696564 Phase 4 Losartan;Placebo
41 Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema Recruiting NCT02682147 Phase 4 Tadalafil;Sildenafil
42 RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD Recruiting NCT02989935 Phase 4
43 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Exercise Performance Recruiting NCT02143609 Phase 4 oxygen;sham oxygen (room air)
44 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep Recruiting NCT02150590 Phase 4 Oxygen;sham oxygen (room air)
45 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4 Low Dose Corticosteroids;High Dose Corticosteroids
46 Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease Recruiting NCT03156231 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
47 Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude Recruiting NCT03173508 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
48 Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude Recruiting NCT03167034 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
49 Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude Recruiting NCT03177837 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
50 Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude Recruiting NCT03177850 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

Anatomical Context for Pulmonary Emphysema

MalaCards organs/tissues related to Pulmonary Emphysema:

39
Lung, Bone, Liver, Heart, Testes, Endothelial, Bone Marrow

Publications for Pulmonary Emphysema

Articles related to Pulmonary Emphysema:

(show top 50) (show all 575)
id Title Authors Year
1
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. ( 28186975 )
2017
2
Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema. ( 28179328 )
2017
3
Bacteriological incidence in pneumonia patients with pulmonary emphysema: a bacterial floral analysis using the 16S ribosomal RNA gene in bronchoalveolar lavage fluid. ( 28790814 )
2017
4
Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. ( 28894173 )
2017
5
A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV. ( 28122034 )
2017
6
Mild pulmonary emphysema a risk factor for interstitial lung disease when using cetuximab for squamous cell carcinoma of the head and neck. ( 28741444 )
2017
7
Pulmonary emphysema is a predictor of pneumothorax after CT-guided transthoracic pulmonary biopsies of pulmonary nodules. ( 28574995 )
2017
8
Images in COPD: Combined Pulmonary Emphysema and Fibrosis with Pulmonary Hypertension. ( 28848914 )
2017
9
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial. ( 28186686 )
2017
10
Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy. ( 28584268 )
2017
11
Prognostic Value of Radiation Pneumonitis After Stereotactic Body Radiotherapy: Effect of Pulmonary Emphysema Quantitated Using CTA Images. ( 28655592 )
2017
12
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. ( 28807355 )
2017
13
Pulmonary Emphysema Cross-Linking with Pulmonary Fibrosis and Vice Versa: a Non-usual Experimental Intervention with Elastase and Bleomycin. ( 28534139 )
2017
14
Improvement of metabolic disorders by an EP(2) receptor agonist via restoration of the subcutaneous adipose tissue in pulmonary emphysema. ( 28263859 )
2017
15
Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens. ( 27445472 )
2016
16
Severity of pulmonary emphysema and lung cancer: analysis using quantitative lobar emphysema scoring. ( 27902611 )
2016
17
Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. ( 27382160 )
2016
18
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model. ( 27644555 )
2016
19
The Effect of Bone Marrow Mononuclear Cells on Lung Regeneration and Apoptosis in a Simple Model of Pulmonary Emphysema. ( 27426096 )
2016
20
Lung volume reduction of pulmonary emphysema: the radiologist task. ( 26807689 )
2016
21
Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice. ( 27555760 )
2016
22
Therapeutic Targeting of the IL-6 Trans-signalling/mTORC1 Axis in Pulmonary Emphysema. ( 27373892 )
2016
23
Comparison of Serum Adiponectin in Smoke-induced Pulmonary Emphysema Rats Fed Different Diets. ( 26830990 )
2016
24
Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model. ( 27489022 )
2016
25
Development of digital phantoms based on a finite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantification. ( 27838881 )
2016
26
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
27
Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study. ( 27692154 )
2016
28
Acute pulmonary emphysema in death by hanging: a morphometric digital study. ( 27448112 )
2016
29
Pulmonary Rehabilitation Improves Exercise Capacity And Molecular Skeletal Muscle Adaptation In Pulmonary Emphysema Patients: 2972 Board #37 June 3, 3: 30 PM - 5: 00 PM. ( 27361541 )
2016
30
Lung cancer, pulmonary emphysema and pleural effusion: An autopsy study. ( 26000874 )
2015
31
Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis. ( 26636084 )
2015
32
Lung Volume Reduction in Pulmonary Emphysema from the Radiologist's Perspective. ( 26062174 )
2015
33
Different profiles of notch signaling in cigarette smoke-induced pulmonary emphysema and bleomycin-induced pulmonary fibrosis. ( 25813392 )
2015
34
Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice. ( 26160987 )
2015
35
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis. ( 26180387 )
2015
36
Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats. ( 26515722 )
2015
37
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages. ( 25757189 )
2015
38
In Vivo Dark-Field Radiography for Early Diagnosis and Staging of Pulmonary Emphysema. ( 25761095 )
2015
39
Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. ( 25651034 )
2015
40
Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. ( 26150711 )
2015
41
Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. ( 25915723 )
2015
42
Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema? ( 25939639 )
2015
43
Development and analysis of a finite element model to simulate pulmonary emphysema in CT imaging. ( 26737750 )
2015
44
Paratracheal air cysts: prevalence and relevance to pulmonary emphysema and bronchiectasis using thoracic multidetector CT. ( 25430529 )
2015
45
Oxidative and proteolysis-related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction. ( 26102076 )
2015
46
Influence of Sinogram-Affirmed Iterative Reconstruction on Computed Tomography-Based Lung Volumetry and Quantification of Pulmonary Emphysema. ( 26466107 )
2015
47
Pulmonary emphysema induced by methylphenidate: experimental study. ( 26018883 )
2015
48
Ventilation/perfusion SPECT/CT in patients with pulmonary emphysema. Evaluation of software-based analysing. ( 25683108 )
2015
49
Pulmonary emphysema and tumor microenvironment in primary lung cancer. ( 26428090 )
2015
50
RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. ( 26646821 )
2015

Variations for Pulmonary Emphysema

Expression for Pulmonary Emphysema

LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Emphysema patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 S100A12 S100 calcium binding protein A12 Lung - 3.38 0.026
2 SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Lung + 3.23 0.020
3 HLA-DOA major histocompatibility complex, class II, DO alpha Lung + 3.20 0.002
Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for Pulmonary Emphysema

Pathways related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 ELANE HMOX1 MMP1 MMP8 MMP9 SERPINA1
2
Show member pathways
13.15 ELN ITGB6 MMP1 MMP12 MMP8 MMP9
3
Show member pathways
12.26 ELANE ELN ITGB6 MMP1 MMP12 MMP8
4 11.94 MMP1 MMP12 MMP9
5 11.79 HMOX1 MMP1 MMP9 TIMP1
6 11.61 HMOX1 MMP9 TIMP1 TIMP2
7 11.52 ELN HMOX1 MMP9 SERPINA1 TIMP1
8 11.44 MMP1 MMP12 MMP9 TIMP1 TIMP2
9 11.16 HMOX1 MMP1 MMP9
10
Show member pathways
11.16 ELANE MMP1 MMP12 MMP8 MMP9 TIMP1
11 11.14 ELANE ELN MMP1 MMP9 TIMP2
12 10.98 MMP9 TIMP1 TIMP2
13 10.9 MMP9 TIMP2
14 10.77 MMP1 TIMP1
15 10.71 MMP1 MMP9

GO Terms for Pulmonary Emphysema

Cellular components related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 ELANE HMOX1 MMP12 MMP8 MMP9 SERPINA1
2 extracellular region GO:0005576 9.9 ELANE ELN MMP1 MMP12 MMP8 MMP9
3 ficolin-1-rich granule lumen GO:1904813 9.58 MMP9 SERPINA1 TIMP2
4 specific granule lumen GO:0035580 9.54 ELANE MMP8 TIMP2
5 tertiary granule lumen GO:1904724 9.5 MMP8 MMP9 TIMP2
6 extracellular matrix GO:0031012 9.43 MMP1 MMP12 MMP8 MMP9 TIMP1 TIMP2
7 proteinaceous extracellular matrix GO:0005578 9.28 ELN MMP1 MMP12 MMP8 MMP9 SERPINA1

Biological processes related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 ELANE MMP1 MMP12 MMP8 MMP9
2 cellular protein metabolic process GO:0044267 9.71 MMP1 SERPINA1 SFTPD TIMP1
3 neutrophil degranulation GO:0043312 9.63 ELANE MMP8 MMP9 SERPINA1 SERPINB1 TIMP2
4 negative regulation of endopeptidase activity GO:0010951 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
5 negative regulation of peptidase activity GO:0010466 9.56 SERPINA1 SERPINB1 TIMP1 TIMP2
6 cellular response to cadmium ion GO:0071276 9.51 HMOX1 MMP9
7 endodermal cell differentiation GO:0035987 9.49 MMP8 MMP9
8 positive regulation of macroautophagy GO:0016239 9.48 HMOX1 SESN2
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
10 negative regulation of metallopeptidase activity GO:1905049 9.37 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.26 MMP1 MMP12 MMP8 MMP9
12 extracellular matrix disassembly GO:0022617 9.23 ELANE ELN MMP1 MMP12 MMP8 MMP9

Molecular functions related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.83 ELANE MMP1 MMP12 MMP8 MMP9
2 zinc ion binding GO:0008270 9.71 MMP1 MMP12 MMP8 MMP9
3 metallopeptidase activity GO:0008237 9.67 MMP1 MMP12 MMP8 MMP9
4 peptidase inhibitor activity GO:0030414 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
5 metalloendopeptidase activity GO:0004222 9.56 MMP1 MMP12 MMP8 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.46 TIMP1 TIMP2
7 protease binding GO:0002020 9.46 ELANE SERPINA1 TIMP1 TIMP2
8 serine-type endopeptidase activity GO:0004252 9.35 ELANE MMP1 MMP12 MMP8 MMP9
9 endopeptidase activity GO:0004175 8.92 ELANE MMP1 MMP12 MMP9

Sources for Pulmonary Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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