MCID: PLM034
MIFTS: 55

Pulmonary Emphysema malady

Categories: Respiratory diseases

Aliases & Classifications for Pulmonary Emphysema

Aliases & Descriptions for Pulmonary Emphysema:

Name: Pulmonary Emphysema 38 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9675
ICD10 33 J43.8
ICD9CM 35 492.8
UMLS 69 C0029607

Summaries for Pulmonary Emphysema

MalaCards based summary : Pulmonary Emphysema is related to berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification and cutis laxa, autosomal recessive type 1, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Pulmonary Emphysema is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Simvastatin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Pulmonary Emphysema

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification 12.0
2 cutis laxa, autosomal recessive type 1 10.9
3 emphysema due to aat deficiency 10.9
4 dancing eyes-dancing feet syndrome 10.3 ELANE ELN
5 kleptomania 10.3 MMP1 MMP9
6 central nervous system adult germ cell tumor 10.2 MMP9 TIMP2
7 diffuse large b-cell lymphoma 10.2 MMP1 MMP9
8 pulmonary embolism and infarction 10.2 ELANE SERPINB1
9 congenital hypomyelination neuropathy 10.2 MMP9 TIMP1
10 tinea profunda 10.2 ELN MMP9
11 optic nerve glioma 10.2 ELANE ELN
12 bardet-biedl syndrome 8 10.2 ELANE ELN SERPINA1
13 tetanus 10.2 ELANE ELN
14 senile atrophy of choroid 10.2 MMP1 MMP9
15 adult-onset distal myopathy due to vcp mutation 10.2 ELN MMP1 MMP9
16 familial renal papillary carcinoma 10.2 ELANE SERPINA1 SERPINB1
17 eating disorder 10.2 ELANE SERPINA1 SERPINB1
18 breast adenomyoepithelioma 10.2 ELANE MMP9 TIMP1
19 adult neuronal ceroid lipofuscinosis 10.2 MMP1 MMP9 TIMP2
20 ectropion 10.2 MMP1 MMP9
21 aminoaciduria 10.2 MMP8 MMP9
22 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.1 ELANE MMP9 TIMP1
23 cavernous malformation 10.1 ELN MMP12 MMP9
24 striated muscle rhabdoid tumor 10.1 MMP9 TIMP1 TIMP2
25 maxillary neoplasm 10.1 MMP9 TIMP1 TIMP2
26 linear porokeratosis 10.1 MMP1 MMP12 MMP9
27 mosaic variegated aneuploidy syndrome 2 10.1 MMP1 MMP8
28 adenoid squamous cell carcinoma 10.1 MMP9 TIMP1 TIMP2
29 angiomyoma 10.1 MMP1 TIMP1 TIMP2
30 major depressive disorder and accelerated response to antidepressant drug treatment 10.1 ELANE ELN SERPINA1 SERPINB1
31 chronic diarrhea due to guanylate cyclase 2c overactivity 10.1 MMP1 MMP8
32 autoimmune polyendocrine syndrome type 1 10.1 MMP9 TIMP1
33 appendix carcinoid tumor 10.1 MMP9 TIMP1
34 cystic lymphangioma 10.1 MMP1 MMP9
35 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 10.1 MMP9 TIMP1 TIMP2
36 infancy electroclinical syndrome 10.1 ELANE MMP8 MMP9
37 stenosis of lacrimal sac 10.1 ELANE MMP8 MMP9
38 peripheral vascular disease 10.1 ELANE MMP1 MMP8
39 fasciitis 10.1 ELANE MMP8 SERPINA1
40 subglottis neoplasm 10.1 HMOX1 MMP1 TIMP2
41 retinal drusen 10.0 ELANE MMP9 TIMP1 TIMP2
42 central nervous system teratoma 10.0 ELN MMP1 MMP9 TIMP1
43 schwannomatosis 10.0 ELN MMP9 TIMP1 TIMP2
44 myelophthisic anemia 10.0 ELN HMOX1 MMP9
45 lung cancer 10.0
46 bronchitis 10.0
47 puerperal pulmonary embolism 10.0 ELN MMP9 TIMP1 TIMP2
48 nervous system cancer 10.0 MMP9 SFTPD TIMP1
49 acute chest syndrome 10.0 ELANE MMP9 SERPINA1 SFTPD
50 vitreoretinopathy, neovascular inflammatory 10.0 MMP1 MMP8 TIMP2

Comorbidity relations with Pulmonary Emphysema via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to Pulmonary Emphysema

Symptoms & Phenotypes for Pulmonary Emphysema

UMLS symptoms related to Pulmonary Emphysema:


coughing, hemoptysis, snoring

MGI Mouse Phenotypes related to Pulmonary Emphysema:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 SESN2 SFTPD TIMP1 TIMP2 ELANE HMOX1
2 hematopoietic system MP:0005397 9.97 ELANE HMOX1 ITGB6 MMP12 MMP9 SERPINB1
3 immune system MP:0005387 9.9 ELANE HMOX1 ITGB6 MMP1 MMP12 MMP8
4 neoplasm MP:0002006 9.35 ELANE MMP1 MMP8 MMP9 TIMP1
5 respiratory system MP:0005388 9.23 HMOX1 ITGB6 MMP12 MMP9 SERPINB1 SESN2

Drugs & Therapeutics for Pulmonary Emphysema

Drugs for Pulmonary Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 246)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Budesonide Approved Phase 4,Phase 3 51333-22-3 63006 5281004
4
Ipratropium Approved Phase 4 22254-24-6, 60205-81-4 43232
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
8
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
9
Losartan Approved Phase 4 114798-26-4 3961
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
11
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
12
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
13 tannic acid Approved, Nutraceutical Phase 4
14 Anesthetics Phase 4,Phase 2,Phase 1
15 Anticholesteremic Agents Phase 4
16 Antimetabolites Phase 4,Phase 1
17 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
18 Hypolipidemic Agents Phase 4,Phase 1
19 Lipid Regulating Agents Phase 4,Phase 1
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
21 Anti-Infective Agents Phase 4,Phase 1
22 Antimalarials Phase 4
23 Antiparasitic Agents Phase 4
24 Antiprotozoal Agents Phase 4
25 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
29 Albuterol Phase 4,Phase 3
30 Anti-Allergic Agents Phase 4,Phase 3,Phase 2
31 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 1
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 Budesonide, Formoterol Fumarate Drug Combination Phase 4,Phase 3
37 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
38
Fluticasone Phase 4,Phase 3,Phase 2 90566-53-3, 80474-14-2 62924 22833648
39 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4,Phase 3
40 Formoterol Fumarate Phase 4,Phase 3,Phase 2
41 glucocorticoids Phase 4,Phase 3,Phase 1
42 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Hormones Phase 4,Phase 3,Phase 2,Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
45 mometasone furoate Phase 4 83919-23-7
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Respiratory System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
49
Salmeterol xinafoate Phase 4,Phase 3 94749-08-3 56801
50 Tiotropium Bromide Phase 4,Phase 2 136310-93-5

Interventional clinical trials:

(show top 50) (show all 465)
id Name Status NCT ID Phase
1 AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation Unknown status NCT01460108 Phase 4
2 EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema Unknown status NCT00730301 Phase 4
3 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype Unknown status NCT01431625 Phase 4
4 Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00680641 Phase 4
5 Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00857038 Phase 4
6 Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma Unknown status NCT00576069 Phase 4
7 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4
8 Airway Clearance for Prevention of COPD Exacerbation Unknown status NCT00181207 Phase 4
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography Unknown status NCT01361984 Phase 4
11 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
12 Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema Completed NCT00570544 Phase 4
13 Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency Completed NCT00261833 Phase 4
14 Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. Completed NCT00670007 Phase 4
15 Efficacy Study of the Effect of Budesonide on Emphysema Completed NCT00232674 Phase 4
16 Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients Completed NCT01336283 Phase 4
17 Efficacy of Losartan in Preventing Progression of COPD Completed NCT00720226 Phase 4
18 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00424528 Phase 4
19 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients Completed NCT00680056 Phase 4
20 Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study Completed NCT01110200 Phase 4
21 Inhaled Steroid Reduces Systemic Inflammation in COPD Completed NCT00175565 Phase 4
22 Change of Inspiratory Peak Flow in COPD Completed NCT00561886 Phase 4
23 Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients Completed NCT02181023 Phase 4
24 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4
25 Dynamic Hyperinflation and Tiotropium Completed NCT00569270 Phase 4
26 An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease Completed NCT00974805 Phase 4
27 Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD Completed NCT00571428 Phase 4
28 A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00857766 Phase 4
29 Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD Completed NCT02209974 Phase 4
30 Study of the Effect of the ROX AC1 on Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease (COPD) Patients Completed NCT00832611 Phase 4
31 Costs & Outcomes of Hospitalization/Treatment With Levalbuterol & Albuterol in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Subjects Completed NCT00667797 Phase 4
32 Altitude Related Illness In Patients With Respiratory Disease Completed NCT02450968 Phase 4
33 Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD Completed NCT01693003 Phase 4
34 Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude Completed NCT02450994 Phase 4
35 Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00202189 Phase 4
36 GLASSIA Infusion Rate Study Completed NCT01651351 Phase 4
37 Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) Completed NCT00396006 Phase 4
38 Small Airways Evaluation and Treatment Recruiting NCT02526758 Phase 4
39 RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD Recruiting NCT02989935 Phase 4
40 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Exercise Performance Recruiting NCT02143609 Phase 4
41 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep Recruiting NCT02150590 Phase 4
42 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4
43 Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease Recruiting NCT03156231 Phase 4
44 Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude Recruiting NCT03173508 Phase 4
45 Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude Recruiting NCT03167034 Phase 4
46 Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude Recruiting NCT03177837 Phase 4
47 Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude Recruiting NCT03177850 Phase 4
48 Stage 1 Study of ARALAST NP and GLASSIA in A1PI Recruiting NCT02722304 Phase 4
49 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis Active, not recruiting NCT03073798 Phase 4
50 Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD Active, not recruiting NCT01745848 Phase 4

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

Anatomical Context for Pulmonary Emphysema

MalaCards organs/tissues related to Pulmonary Emphysema:

39
Lung, Bone, Testes, Neutrophil, Skeletal Muscle, Endothelial, Bone Marrow

Publications for Pulmonary Emphysema

Articles related to Pulmonary Emphysema:

(show top 50) (show all 561)
id Title Authors Year
1
Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema. ( 28179328 )
2017
2
Lung volume reduction of pulmonary emphysema: the radiologist task. ( 26807689 )
2016
3
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model. ( 27644555 )
2016
4
Comparison of Serum Adiponectin in Smoke-induced Pulmonary Emphysema Rats Fed Different Diets. ( 26830990 )
2016
5
Acute pulmonary emphysema in death by hanging: a morphometric digital study. ( 27448112 )
2016
6
Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. ( 27382160 )
2016
7
Pulmonary Rehabilitation Improves Exercise Capacity And Molecular Skeletal Muscle Adaptation In Pulmonary Emphysema Patients: 2972 Board #37 June 3, 3: 30 PM - 5: 00 PM. ( 27361541 )
2016
8
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
9
Development of digital phantoms based on a finite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantification. ( 27838881 )
2016
10
Therapeutic Targeting of the IL-6 Trans-signalling/mTORC1 Axis in Pulmonary Emphysema. ( 27373892 )
2016
11
Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model. ( 27489022 )
2016
12
Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study. ( 27692154 )
2016
13
Severity of pulmonary emphysema and lung cancer: analysis using quantitative lobar emphysema scoring. ( 27902611 )
2016
14
The Effect of Bone Marrow Mononuclear Cells on Lung Regeneration and Apoptosis in a Simple Model of Pulmonary Emphysema. ( 27426096 )
2016
15
Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens. ( 27445472 )
2016
16
Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice. ( 27555760 )
2016
17
Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. ( 25651034 )
2015
18
Influence of Sinogram-Affirmed Iterative Reconstruction on Computed Tomography-Based Lung Volumetry and Quantification of Pulmonary Emphysema. ( 26466107 )
2015
19
Pulmonary emphysema and tumor microenvironment in primary lung cancer. ( 26428090 )
2015
20
In Vivo Dark-Field Radiography for Early Diagnosis and Staging of Pulmonary Emphysema. ( 25761095 )
2015
21
Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats. ( 26515722 )
2015
22
Development and analysis of a finite element model to simulate pulmonary emphysema in CT imaging. ( 26737750 )
2015
23
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages. ( 25757189 )
2015
24
RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. ( 26646821 )
2015
25
Ventilation/perfusion SPECT/CT in patients with pulmonary emphysema. Evaluation of software-based analysing. ( 25683108 )
2015
26
Paratracheal air cysts: prevalence and relevance to pulmonary emphysema and bronchiectasis using thoracic multidetector CT. ( 25430529 )
2015
27
Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema? ( 25939639 )
2015
28
Lung cancer, pulmonary emphysema and pleural effusion: An autopsy study. ( 26000874 )
2015
29
Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice. ( 26160987 )
2015
30
Different profiles of notch signaling in cigarette smoke-induced pulmonary emphysema and bleomycin-induced pulmonary fibrosis. ( 25813392 )
2015
31
Oxidative and proteolysis-related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction. ( 26102076 )
2015
32
Lung Volume Reduction in Pulmonary Emphysema from the Radiologist's Perspective. ( 26062174 )
2015
33
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis. ( 26180387 )
2015
34
The Relationship of Educational Attainment with Pulmonary Emphysema and Airway Wall Thickness. ( 25822654 )
2015
35
Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis. ( 26636084 )
2015
36
Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. ( 26150711 )
2015
37
Pulmonary emphysema induced by methylphenidate: experimental study. ( 26018883 )
2015
38
Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. ( 25915723 )
2015
39
Quantitative computed tomography of pulmonary emphysema and ventricular function in chronic obstructive pulmonary disease patients with pulmonary hypertension. ( 25469102 )
2014
40
Towards local progression estimation of pulmonary emphysema using CT. ( 24506626 )
2014
41
Novel therapeutic approach for pulmonary emphysema using gelatin microspheres releasing basic fibroblast growth factor in a canine model. ( 24535698 )
2014
42
Improved diagnosis of pulmonary emphysema using in vivo dark-field radiography. ( 24853070 )
2014
43
Classification of healthy subjects and patients with pulmonary emphysema using continuous respiratory sounds. ( 25569899 )
2014
44
Histopathological characteristics of pulmonary emphysema in experimental model. ( 25184805 )
2014
45
Three-dimensional analysis of alveolar wall destruction in the early stage of pulmonary emphysema. ( 25220884 )
2014
46
The relationship between atherosclerosis and pulmonary emphysema. ( 25151763 )
2014
47
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. ( 24962763 )
2014
48
Congenital tuberculosis complicated by interstitial pulmonary emphysema. ( 24741540 )
2014
49
High-density lipoproteins potentiate I+1-antitrypsin therapy in elastase-induced pulmonary emphysema. ( 24787644 )
2014
50
Papain-induced experimental pulmonary emphysema in male and female mice. ( 24931736 )
2014

Variations for Pulmonary Emphysema

Expression for Pulmonary Emphysema

LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Emphysema patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 S100A12 S100 calcium binding protein A12 Lung - 3.38 0.026
2 SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Lung + 3.23 0.020
3 HLA-DOA major histocompatibility complex, class II, DO alpha Lung + 3.20 0.002
Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for Pulmonary Emphysema

Pathways related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 ELANE HMOX1 MMP1 MMP8 MMP9 SERPINA1
2
Show member pathways
13.15 ELN ITGB6 MMP1 MMP12 MMP8 MMP9
3
Show member pathways
12.26 ELANE ELN ITGB6 MMP1 MMP12 MMP8
4 11.94 MMP1 MMP12 MMP9
5 11.79 HMOX1 MMP1 MMP9 TIMP1
6 11.61 HMOX1 MMP9 TIMP1 TIMP2
7 11.52 ELN HMOX1 MMP9 SERPINA1 TIMP1
8 11.44 MMP1 MMP12 MMP9 TIMP1 TIMP2
9 11.16 HMOX1 MMP1 MMP9
10
Show member pathways
11.16 ELANE MMP1 MMP12 MMP8 MMP9 TIMP1
11 11.14 ELANE ELN MMP1 MMP9 TIMP2
12 10.98 MMP9 TIMP1 TIMP2
13 10.89 MMP9 TIMP2
14 10.77 MMP1 TIMP1
15 10.71 MMP1 MMP9

GO Terms for Pulmonary Emphysema

Cellular components related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ELANE ELN MMP1 MMP12 MMP8 MMP9
2 extracellular matrix GO:0031012 9.73 MMP1 MMP12 MMP8 MMP9 TIMP1 TIMP2
3 extracellular space GO:0005615 9.65 ELANE HMOX1 MMP12 MMP8 MMP9 SERPINA1
4 ficolin-1-rich granule lumen GO:1904813 9.58 MMP9 SERPINA1 TIMP2
5 specific granule lumen GO:0035580 9.54 ELANE MMP8 TIMP2
6 tertiary granule lumen GO:1904724 9.5 MMP8 MMP9 TIMP2
7 proteinaceous extracellular matrix GO:0005578 9.28 ELN MMP1 MMP12 MMP8 MMP9 SERPINA1

Biological processes related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 ELANE MMP1 MMP12 MMP8 MMP9
2 cellular protein metabolic process GO:0044267 9.71 MMP1 SERPINA1 SFTPD TIMP1
3 negative regulation of endopeptidase activity GO:0010951 9.67 SERPINA1 SERPINB1 TIMP1 TIMP2
4 neutrophil degranulation GO:0043312 9.63 ELANE MMP8 MMP9 SERPINA1 SERPINB1 TIMP2
5 negative regulation of peptidase activity GO:0010466 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
6 cellular response to cadmium ion GO:0071276 9.51 HMOX1 MMP9
7 endodermal cell differentiation GO:0035987 9.49 MMP8 MMP9
8 positive regulation of macroautophagy GO:0016239 9.48 HMOX1 SESN2
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
10 negative regulation of metallopeptidase activity GO:1905049 9.26 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.26 MMP1 MMP12 MMP8 MMP9
12 extracellular matrix disassembly GO:0022617 9.23 ELANE ELN MMP1 MMP12 MMP8 MMP9

Molecular functions related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 ELANE MMP1 MMP12 MMP8 MMP9
2 metallopeptidase activity GO:0008237 9.67 MMP1 MMP12 MMP8 MMP9
3 peptidase inhibitor activity GO:0030414 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
4 metalloendopeptidase activity GO:0004222 9.56 MMP1 MMP12 MMP8 MMP9
5 serine-type endopeptidase activity GO:0004252 9.55 ELANE MMP1 MMP12 MMP8 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.43 TIMP1 TIMP2
7 protease binding GO:0002020 9.26 ELANE SERPINA1 TIMP1 TIMP2
8 endopeptidase activity GO:0004175 8.92 ELANE MMP1 MMP12 MMP9

Sources for Pulmonary Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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