Aliases & Classifications for Pulmonary Emphysema

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Pulmonary Emphysema, Aliases & Descriptions:

Name: Pulmonary Emphysema 30 9 11 43 60


External Ids:

Disease Ontology9 DOID:9675
MeSH33 D011656
ICD9CM27 492.8

Summaries for Pulmonary Emphysema

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MalaCards based summary: Pulmonary Emphysema is related to bronchitis and cutis laxa. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are FOXA1 transcription factor network and Cell adhesion Cell matrix glycoconjugates. The drugs aminophylline and oxtriphylline and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Related Diseases for Pulmonary Emphysema

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Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis31.2ELANE, SERPINA1
2cutis laxa31.0ELN, ELANE
3emphysema due to aat deficiency30.8SERPINA1, ELANE
4pulmonary fibrosis30.7ELANE, ELN, SFTPD
5periodontal disease30.7ELANE
6pulmonary hypertension30.6ELN, ELANE
7respiratory failure30.4SERPINA1, SFTPD
8lung cancer30.4SFTPD, SERPINA1, MMP8, MMP12
9periodontitis30.3MMP8, ELANE
10extrinsic allergic alveolitis30.2CTSG, ELANE, SFTPD
11tuberculosis30.0CTSG, SERPINA1, SFTPD
12aneurysm29.8MMP8, ELN, ELANE, MMP12, SERPINA1
13bronchiectasis29.8CTSG, ELANE, SERPINA1, MMP8
14asthma29.6CTSG, ELANE, MMP8, MMP12, SERPINA1, SFTPD
15atherosclerosis29.6ELANE, MMP8, FGF23, ELN, MMP12
16cystic fibrosis29.5SFTPD, SERPINA1, ELANE, ELN, CTSG
17pneumonia29.3MMP12, CTSG, MMP8, ELANE, SFTPD, SERPINA1
18pulmonary function10.5
19berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.4
20marfan syndrome10.3
21endotheliitis10.3
22aspergillosis10.3SFTPD, ELANE
23acute respiratory distress syndrome10.3ELANE, SFTPD
24interstitial emphysema10.3
25ehlers-danlos syndrome10.3ELN, ELANE
26cerebral aneurysms10.3ELN, ELANE
27chronic ulcer of skin10.3ELANE, MMP8
28vascular disease10.3ELN, ELANE
29chorioamnionitis10.3MMP8, ELANE
30collagen disease10.2SFTPD, ELN
31cholangitis, primary sclerosing10.2ELANE, CTSG
32bronchiolitis10.2
33diffuse pulmonary fibrosis10.2
34pneumothorax10.2
35cutis laxa, autosomal recessive type 110.2
36tracheobronchomalacia10.2
37connective tissue disease10.2ELN, SFTPD
38pulmonary fibrosis, idiopathic10.2ELANE, SFTPD
39acute pancreatitis10.2SERPINA1, ELANE
40keloids10.1MMP8, ELN
41cork-handlers' disease10.1CTSG, ELANE
42pulmonary disease, chronic obstructive10.1MMP12, SERPINA1, SFTPD
43pancreatitis, hereditary10.1SERPINA1, ELANE
44keratoconus10.1CTSG, MMP8
45intracranial aneurysm10.1ELN, SERPINA1, ELANE
46peritonitis10.1MMP8, CTSG
47osteoporosis10.0
48salla disease10.0
49hemolytic anemia10.0
50neuroendocrine carcinoma10.0

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Symptoms for Pulmonary Emphysema

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Drugs & Therapeutics for Pulmonary Emphysema

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Genetic Tests for Pulmonary Emphysema

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Anatomical Context for Pulmonary Emphysema

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MalaCards organs/tissues related to Pulmonary Emphysema:

31
Kidney, Lung, Bone, Testes, Neutrophil, Endothelial, Skeletal muscle, Bone marrow, Heart, Colon, Liver, Placenta

Animal Models for Pulmonary Emphysema or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Emphysema:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3FGF23, ELN, MMP12, SFTPD
2MP:00053977.6SFTPD, MMP12, ELANE, CTSG, FGF23
3MP:00053877.3FGF23, CTSG, ELANE, MMP8, MMP12, SFTPD

Publications for Pulmonary Emphysema

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Articles related to Pulmonary Emphysema:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Pulmonary Emphysema Subtypes on Computed Tomography: The MESA COPD Study. (24384106)
2014
2
Air leaks and pulmonary emphysema in infants: selective bronchial intubation or balloon occlusion? (23676528)
2013
3
Significant correlation between endothelial nitric oxide synthase (eNOS) expression and alveolar repair in elastase-induced rat pulmonary emphysema. (22911252)
2013
4
Baseline regional perfusion impacts exercise response to endobronchial valve therapy in advanced pulmonary emphysema. (23828481)
2013
5
Tidal Expiratory Flow Limitation at Rest as a Functional Marker of Pulmonary Emphysema in Moderate-to-Severe COPD. (24102405)
2013
6
Relationship between pulmonary emphysema and renal function in smokers. (23648928)
2013
7
Intravenous and Intratracheal Mesenchymal Stromal Cell Injection in a Mouse Model of Pulmonary Emphysema. (24295402)
2013
8
Ceramides: a potential therapeutic target in pulmonary emphysema. (24083966)
2013
9
Unfolding the mechanisms of progression of pulmonary emphysema in COPD. (23024322)
2012
10
Elastase-induced pulmonary emphysema: insights from experimental models. (22159348)
2011
11
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. (21706041)
2011
12
Pulmonary emphysema induced by cigarette smoke solution and lipopolysaccharide in guinea pigs. (19721232)
2009
13
Pulmonary emphysema: size distribution of emphysematous spaces on multidetector CT images--comparison with macroscopic and microscopic morphometry. (18710992)
2008
14
Texture-based quantification of pulmonary emphysema on high-resolution computed tomography: comparison with density-based quantification and correlation with pulmonary function test. (18496044)
2008
15
Morphological mechanism of the development of pulmonary emphysema in klotho mice. (17284608)
2007
16
The influence of pulmonary receptors on respiratory drive in a rabbit model of pulmonary emphysema. (16971190)
2007
17
Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification--comparison with macroscopic and microscopic morphometry. (17392257)
2007
18
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. (15944319)
2005
19
Peripheral solitary pulmonary nodule: CT findings in patients with pulmonary emphysema. (15716392)
2005
20
Induction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats. (15764723)
2005
21
A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. (15033705)
2003
22
Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. (14688706)
2003
23
Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. (11978916)
2002
24
Liquid ventilation in an infant with persistent interstitial pulmonary emphysema. (11344676)
2001
25
Cutis laxa and pulmonary emphysema. (18610669)
2001
26
Subjective symptoms and prognosis after lung volume reduction surgery in patients with severe pulmonary emphysema. (10554418)
1999
27
Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. (10084478)
1999
28
Body position, membrane diffusing capacity and pulmonary capillary blood volume in chronic bronchitis and pulmonary emphysema. (10367481)
1999
29
Surgical treatment for patients with lung cancer complicated by severe pulmonary emphysema. (10658374)
1999
30
Preferential binding of lysozyme to elastic fibres in pulmonary emphysema. (9659355)
1998
31
The usefulness of 99mTc-Technegas scintigraphy for diagnosing pulmonary impairment caused by pulmonary emphysema. (9588225)
1998
32
Macrophages in lung tissue from patients with pulmonary emphysema express both inducible and endothelial nitric oxide synthase. (9688186)
1998
33
Improvement in ejection fraction by hydrotherapy as rehabilitation in patients with chronic pulmonary emphysema. (9859136)
1998
34
Effect of lung volume reduction surgery on pulmonary hemodynamics in severe pulmonary emphysema. (9628374)
1998
35
Effect of pulmonary emphysema on diaphragm capillary geometry. (9049743)
1997
36
Quantitative assessment of the spatial distribution of low attenuation areas on X-ray CT using texture analysis in patients with chronic pulmonary emphysema. (9083798)
1997
37
HRCT evident fibrosis in isolated pulmonary emphysema. (9071310)
1997
38
Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. (9266901)
1997
39
Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema. (8815971)
1996
40
An automated method to assess the distribution of low attenuation areas on chest CT scans in chronic pulmonary emphysema patients. (7956377)
1994
41
Single breath N2 washout in papain-induced pulmonary emphysema. (2768646)
1989
42
The deposition, distribution and retention of inhaled 239PuO2 in the lungs of rats with pulmonary emphysema. (6908591)
1981
43
Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. (7233186)
1981
44
Serum alpha 1 antitrypsin in pulmonary emphysema. (6976962)
1981
45
Pulmonary emphysema associated with the FZ alpha 1-antitrypsin phenotype. (6970613)
1981
46
Cadmium and pulmonary emphysema. (6103468)
1980
47
Prevalence, severity, and types of pulmonary emphysema in a population of deaths in a Finnish city. Correlation with age, sex and smoking. (684379)
1978
48
Acute bovine pulmonary emphysema produced by Perilla frutescens. (568714)
1978
49
IPPB in severe pulmonary emphysema: successful results. (799829)
1976
50
Progressive pulmonary emphysema associated with congenital generalized elastolysis (cutis laxa). (4428056)
1974

Variations for Pulmonary Emphysema

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Expression for genes affiliated with Pulmonary Emphysema

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Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

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Pathways related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FOXA transcription factor networks36
9.6SFTPD, SERPINA1
29.6ELANE, ELN
3
Show member pathways
9.0MMP12, MMP8, ELN
4
Show member pathways
Metalloproteases in connective tissue degradation
9.0MMP12, MMP8, ELN
5
Show member pathways
8.6MMP12, MMP8, ELANE, CTSG
6
Show member pathways
8.1MMP12, MMP8, ELANE, ELN, CTSG

Compounds for genes affiliated with Pulmonary Emphysema

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Compounds related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate4310.2SFTPD, ELANE
2sivelestat4310.1ELANE, SFTPD
3isodesmosine4310.0ELN, ELANE
4tannins439.9ELANE, ELN
5hydroxylysine439.9SFTPD, ELN
6elastatinal439.9ELANE, CTSG
74-nitroanilide439.9ELANE, CTSG
8saccharin43 210.9CTSG, ELANE
9chymostatin439.8CTSG, ELANE
10gi 254023x599.8MMP12, MMP8
11pmsf439.8ELANE, CTSG
12uk 383367599.8MMP8, MMP12
13epsilon aminocaproic acid439.8CTSG, ELANE
14gm 6001599.8MMP12, MMP8
15cacl2439.7ELN, MMP8
16hydroxamate439.7MMP8, MMP12
17marimastat43 59 1211.7MMP12, MMP8
18batimastat43 59 1211.6MMP8, MMP12, ELANE
19desmosine439.6ELN, SERPINA1, ELANE
20carbon439.6SFTPD, ELN, ELANE
21phosphonate439.5MMP8, CTSG
22doxycycline43 1210.5ELN, ELANE, MMP8
23endotoxin439.5CTSG, ELANE, SFTPD
24vitamin a43 24 1211.5ELN, SERPINA1, ELANE
25nh4cl439.4ELN, CTSG
26thermolysin439.4ELANE, ELN, CTSG
27phosphoramidon43 1210.4CTSG, ELANE
28sodium dodecylsulfate439.4CTSG, ELANE, ELN
29carbohydrates439.3ELN, SFTPD, CTSG
30oligonucleotide439.0MMP8, MMP12, SERPINA1, SFTPD
31phospholipid439.0SFTPD, CTSG, SERPINA1
32hocl439.0SERPINA1, CTSG, MMP8, ELANE
33diisopropylfluorophosphate439.0CTSG, ELN, ELANE, SERPINA1
34(4-aminophenyl)mercuric acetate438.9CTSG, ELN, ELANE, MMP8
35polysaccharide438.9SFTPD, SERPINA1, CTSG, ELN
36vitamin d438.9ELANE, FGF23, ELN
37oxygen43 249.8SERPINA1, MMP12, SFTPD, MMP8, ELANE
38lactate438.5SFTPD, MMP8, ELANE, ELN, CTSG
39nitric oxide43 24 1210.5SFTPD, CTSG, MMP8, MMP12, SERPINA1
40retinoic acid43 249.5ELN, ELANE, MMP8, CTSG
41lipid438.5SERPINA1, SFTPD, MMP12, MMP8, CTSG
42h2o2438.4CTSG, ELN, ELANE, MMP8, SERPINA1
43creatinine438.4CTSG, FGF23, ELN, SERPINA1
44proline438.4FGF23, CTSG, ELN, MMP8
45glucose438.2SFTPD, CTSG, SERPINA1, MMP8
46heparin43 28 24 1211.1FGF23, CTSG, ELN, ELANE, SERPINA1
47cysteine438.1ELN, ELANE, SFTPD, MMP8, SERPINA1, CTSG
48fibrinogen438.0SERPINA1, MMP12, MMP8, ELANE, ELN, CTSG
49calcium43 49 24 1210.6SFTPD, MMP12, ELN, CTSG, FGF23, MMP8
50serine436.8FGF23, ELN, ELANE, SFTPD, MMP12, CTSG

GO Terms for genes affiliated with Pulmonary Emphysema

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Cellular components related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.5CTSG, ELANE
2proteinaceous extracellular matrixGO:00055788.5SERPINA1, MMP12, MMP8, ELN
3extracellular spaceGO:00056157.4FGF23, CTSG, MMP8, SERPINA1, SFTPD
4extracellular regionGO:00055766.4FGF23, SFTPD, SERPINA1, MMP12, MMP8, ELANE

Biological processes related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:00427429.8ELANE, SFTPD
2positive regulation of immune responseGO:00507789.6ELANE, CTSG
3negative regulation of growth of symbiont in hostGO:00441309.4CTSG, ELANE
4collagen catabolic processGO:00305749.3ELANE, MMP8, MMP12
5respiratory gaseous exchangeGO:00075859.3ELN, SFTPD
6response to lipopolysaccharideGO:00324969.1SERPINA1, ELANE, CTSG
7proteolysisGO:00065088.7CTSG, MMP12, MMP8, ELANE
8extracellular matrix disassemblyGO:00226178.3MMP12, MMP8, ELANE, ELN, CTSG
9extracellular matrix organizationGO:00301988.2CTSG, ELN, ELANE, MMP12, MMP8

Molecular functions related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:00041759.7ELANE, MMP12
2metalloendopeptidase activityGO:00042229.5MMP8, MMP12
3peptidase activityGO:00082339.4ELANE, CTSG
4protease bindingGO:00020209.4SERPINA1, ELANE
5serine-type endopeptidase activityGO:00042529.1CTSG, ELANE, MMP8

Products for genes affiliated with Pulmonary Emphysema

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Sources for Pulmonary Emphysema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet