MCID: PLM034
MIFTS: 58

Pulmonary Emphysema malady

Respiratory diseases category
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Summaries for Pulmonary Emphysema

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Wikipedia:65 Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and... more...

MalaCards based summary: Pulmonary Emphysema is related to bronchitis and cutis laxa. An important gene associated with Pulmonary Emphysema is ELANE (elastase, neutrophil expressed), and among its related pathways are FOXA1 transcription factor network and Cell adhesion Cell matrix glycoconjugates. The drugs acetylcysteine and aminophylline and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Emphysema

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Pulmonary Emphysema, Aliases & Descriptions:

Name: Pulmonary Emphysema 30 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:9675
ICD9CM27 492.8
MeSH34 D011656

Related Diseases for Pulmonary Emphysema

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Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis31.2ELANE, SERPINA1
2cutis laxa31.0ELANE, ELN
3chronic obstructive pulmonary disease30.8SFTPD, SERPINA1, MMP12
4periodontal disease30.7ELANE
5pulmonary fibrosis30.7ELN, ELANE, SFTPD
6pulmonary hypertension30.5ELN, ELANE
7respiratory failure30.4SFTPD, SERPINA1
8periodontitis30.3MMP8, ELANE
9idiopathic pulmonary fibrosis30.3ELANE, SFTPD
10lung cancer30.3MMP8, MMP12, SERPINA1, SFTPD
11extrinsic allergic alveolitis30.2CTSG, ELANE, SFTPD
12tuberculosis30.1SFTPD, SERPINA1, CTSG
13aneurysm29.8SERPINA1, MMP12, MMP8, ELANE, ELN
14asthma29.6SFTPD, SERPINA1, MMP12, MMP8, ELANE, CTSG
15atherosclerosis29.6MMP12, MMP8, ELANE, ELN, FGF23
16cystic fibrosis29.6SFTPD, SERPINA1, ELANE, ELN, CTSG
17pneumonia29.3SFTPD, SERPINA1, MMP12, MMP8, ELANE, CTSG
18pulmonary function10.5
19alpha 1-antitrypsin deficiency10.4
20berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification10.4
21marfan syndrome10.3
22endotheliitis10.3
23aspergillosis10.3ELANE, SFTPD
24emphysema due to aat deficiency10.3SERPINA1, ELANE
25adult respiratory distress syndrome10.3ELANE, SFTPD
26interstitial emphysema10.3
27ehlers-danlos syndrome10.3ELANE, ELN
28cerebral aneurysms10.3ELANE, ELN
29vascular disease10.3ELANE, ELN
30chorioamnionitis10.3MMP8, ELANE
31collagen disease10.3ELN, SFTPD
32primary sclerosing cholangitis10.2CTSG, ELANE
33hypertension10.2
34bronchiolitis10.2
35diffuse pulmonary fibrosis10.2
36pneumothorax10.2
37tracheobronchomalacia10.2
38connective tissue disease10.2ELN, SFTPD
39acute pancreatitis10.2ELANE, SERPINA1
40keloids10.2ELN, MMP8
41cork-handlers' disease10.1CTSG, ELANE
42pancreatitis, chronic10.1ELANE, SERPINA1
43keratoconus10.1MMP8, CTSG
44intracranial aneurysm10.1ELN, ELANE, SERPINA1
45peritonitis10.1MMP8, CTSG
46sepsis10.0CTSG, ELANE, SFTPD
47hemolytic anemia10.0
48osteoporosis10.0
49neuroendocrine carcinoma10.0
50spontaneous tension pneumothorax10.0

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to pulmonary emphysema

Symptoms for Pulmonary Emphysema

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Drugs & Therapeutics for Pulmonary Emphysema

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Emphysema

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

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Anatomical Context for Pulmonary Emphysema

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MalaCards organs/tissues related to Pulmonary Emphysema:

32
Lung, Bone, Testes, Neutrophil, Endothelial, Skeletal muscle, Bone marrow, Heart, Colon, Kidney, Liver, Placenta

Animal Models for Pulmonary Emphysema or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Emphysema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3FGF23, ELN, MMP12, SFTPD
2MP:00053977.6SFTPD, MMP12, ELANE, CTSG, FGF23
3MP:00053877.3FGF23, CTSG, ELANE, MMP8, MMP12, SFTPD

Publications for Pulmonary Emphysema

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Articles related to Pulmonary Emphysema:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Pulmonary Emphysema Subtypes on Computed Tomography: The MESA COPD Study. (24384106)
2014
2
Air leaks and pulmonary emphysema in infants: selective bronchial intubation or balloon occlusion? (23676528)
2013
3
Significant correlation between endothelial nitric oxide synthase (eNOS) expression and alveolar repair in elastase-induced rat pulmonary emphysema. (22911252)
2013
4
Baseline regional perfusion impacts exercise response to endobronchial valve therapy in advanced pulmonary emphysema. (23828481)
2013
5
Tidal Expiratory Flow Limitation at Rest as a Functional Marker of Pulmonary Emphysema in Moderate-to-Severe COPD. (24102405)
2013
6
Relationship between pulmonary emphysema and renal function in smokers. (23648928)
2013
7
Intravenous and Intratracheal Mesenchymal Stromal Cell Injection in a Mouse Model of Pulmonary Emphysema. (24295402)
2013
8
Ceramides: a potential therapeutic target in pulmonary emphysema. (24083966)
2013
9
Unfolding the mechanisms of progression of pulmonary emphysema in COPD. (23024322)
2012
10
Elastase-induced pulmonary emphysema: insights from experimental models. (22159348)
2011
11
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. (21706041)
2011
12
Pulmonary emphysema induced by cigarette smoke solution and lipopolysaccharide in guinea pigs. (19721232)
2009
13
Pulmonary emphysema: size distribution of emphysematous spaces on multidetector CT images--comparison with macroscopic and microscopic morphometry. (18710992)
2008
14
Texture-based quantification of pulmonary emphysema on high-resolution computed tomography: comparison with density-based quantification and correlation with pulmonary function test. (18496044)
2008
15
Morphological mechanism of the development of pulmonary emphysema in klotho mice. (17284608)
2007
16
The influence of pulmonary receptors on respiratory drive in a rabbit model of pulmonary emphysema. (16971190)
2007
17
Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification--comparison with macroscopic and microscopic morphometry. (17392257)
2007
18
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. (15944319)
2005
19
Peripheral solitary pulmonary nodule: CT findings in patients with pulmonary emphysema. (15716392)
2005
20
Induction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats. (15764723)
2005
21
A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. (15033705)
2003
22
Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. (14688706)
2003
23
Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. (11978916)
2002
24
Liquid ventilation in an infant with persistent interstitial pulmonary emphysema. (11344676)
2001
25
Cutis laxa and pulmonary emphysema. (18610669)
2001
26
Subjective symptoms and prognosis after lung volume reduction surgery in patients with severe pulmonary emphysema. (10554418)
1999
27
Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. (10084478)
1999
28
Body position, membrane diffusing capacity and pulmonary capillary blood volume in chronic bronchitis and pulmonary emphysema. (10367481)
1999
29
Preferential binding of lysozyme to elastic fibres in pulmonary emphysema. (9659355)
1998
30
The usefulness of 99mTc-Technegas scintigraphy for diagnosing pulmonary impairment caused by pulmonary emphysema. (9588225)
1998
31
Macrophages in lung tissue from patients with pulmonary emphysema express both inducible and endothelial nitric oxide synthase. (9688186)
1998
32
Improvement in ejection fraction by hydrotherapy as rehabilitation in patients with chronic pulmonary emphysema. (9859136)
1998
33
Effect of lung volume reduction surgery on pulmonary hemodynamics in severe pulmonary emphysema. (9628374)
1998
34
Effect of pulmonary emphysema on diaphragm capillary geometry. (9049743)
1997
35
Quantitative assessment of the spatial distribution of low attenuation areas on X-ray CT using texture analysis in patients with chronic pulmonary emphysema. (9083798)
1997
36
HRCT evident fibrosis in isolated pulmonary emphysema. (9071310)
1997
37
Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. (9266901)
1997
38
Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema. (8815971)
1996
39
An automated method to assess the distribution of low attenuation areas on chest CT scans in chronic pulmonary emphysema patients. (7956377)
1994
40
Single breath N2 washout in papain-induced pulmonary emphysema. (2768646)
1989
41
Chest drains for pulmonary emphysema. (6135935)
1983
42
The deposition, distribution and retention of inhaled 239PuO2 in the lungs of rats with pulmonary emphysema. (6908591)
1981
43
Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. (7233186)
1981
44
Serum alpha 1 antitrypsin in pulmonary emphysema. (6976962)
1981
45
Pulmonary emphysema associated with the FZ alpha 1-antitrypsin phenotype. (6970613)
1981
46
Cadmium and pulmonary emphysema. (6103468)
1980
47
Prevalence, severity, and types of pulmonary emphysema in a population of deaths in a Finnish city. Correlation with age, sex and smoking. (684379)
1978
48
Acute bovine pulmonary emphysema produced by Perilla frutescens. (568714)
1978
49
IPPB in severe pulmonary emphysema: successful results. (799829)
1976
50
Progressive pulmonary emphysema associated with congenital generalized elastolysis (cutis laxa). (4428056)
1974

Variations for Pulmonary Emphysema

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Expression for genes affiliated with Pulmonary Emphysema

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Expression patterns in normal tissues for genes affiliated with Pulmonary Emphysema

Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for genes affiliated with Pulmonary Emphysema

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Compounds for genes affiliated with Pulmonary Emphysema

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Compounds related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate4410.2SFTPD, ELANE
2sivelestat4410.1ELANE, SFTPD
3isodesmosine4410.0ELN, ELANE
4tannins449.9ELANE, ELN
5hydroxylysine449.9SFTPD, ELN
6elastatinal449.9ELANE, CTSG
74-nitroanilide449.9ELANE, CTSG
8saccharin44 210.9CTSG, ELANE
9chymostatin449.8CTSG, ELANE
10gi 254023x619.8MMP12, MMP8
11pmsf449.8ELANE, CTSG
12uk 383367619.8MMP8, MMP12
13epsilon aminocaproic acid449.8CTSG, ELANE
14gm 6001619.8MMP12, MMP8
15cacl2449.7ELN, MMP8
16hydroxamate449.7MMP8, MMP12
17marimastat44 61 1111.7MMP12, MMP8
18batimastat44 61 1111.6MMP8, MMP12, ELANE
19desmosine449.6ELN, SERPINA1, ELANE
20carbon449.6SFTPD, ELN, ELANE
21phosphonate449.5MMP8, CTSG
22doxycycline44 1110.5ELN, ELANE, MMP8
23endotoxin449.5CTSG, ELANE, SFTPD
24vitamin a44 24 1111.5ELN, SERPINA1, ELANE
25nh4cl449.4ELN, CTSG
26thermolysin449.4ELANE, ELN, CTSG
27phosphoramidon44 1110.4CTSG, ELANE
28sodium dodecylsulfate449.4CTSG, ELANE, ELN
29carbohydrates449.3ELN, SFTPD, CTSG
30oligonucleotide449.0MMP8, MMP12, SERPINA1, SFTPD
31phospholipid449.0SFTPD, CTSG, SERPINA1
32hocl449.0SERPINA1, CTSG, MMP8, ELANE
33diisopropylfluorophosphate449.0CTSG, ELN, ELANE, SERPINA1
34(4-aminophenyl)mercuric acetate448.9CTSG, ELN, ELANE, MMP8
35polysaccharide448.9SFTPD, SERPINA1, CTSG, ELN
36vitamin d448.9ELANE, FGF23, ELN
37oxygen44 249.8SERPINA1, MMP12, SFTPD, MMP8, ELANE
38lactate448.5SFTPD, MMP8, ELANE, ELN, CTSG
39nitric oxide44 24 1110.5SFTPD, CTSG, MMP8, MMP12, SERPINA1
40retinoic acid44 249.5ELN, ELANE, MMP8, CTSG
41lipid448.5SERPINA1, SFTPD, MMP12, MMP8, CTSG
42h2o2448.4CTSG, ELN, ELANE, MMP8, SERPINA1
43creatinine448.4CTSG, FGF23, ELN, SERPINA1
44proline448.4FGF23, CTSG, ELN, MMP8
45glucose448.2SFTPD, CTSG, SERPINA1, MMP8
46heparin44 28 24 1111.1FGF23, CTSG, ELN, ELANE, SERPINA1
47cysteine448.1ELN, ELANE, SFTPD, MMP8, SERPINA1, CTSG
48fibrinogen448.0SERPINA1, MMP12, MMP8, ELANE, ELN, CTSG
49calcium44 50 24 1110.6SFTPD, MMP12, ELN, CTSG, FGF23, MMP8
50serine446.8FGF23, ELN, ELANE, SFTPD, MMP12, CTSG

GO Terms for genes affiliated with Pulmonary Emphysema

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Cellular components related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.5CTSG, ELANE
2proteinaceous extracellular matrixGO:0055788.5SERPINA1, MMP12, MMP8, ELN
3extracellular spaceGO:0056157.4FGF23, CTSG, MMP8, SERPINA1, SFTPD
4extracellular regionGO:0055766.4FGF23, SFTPD, SERPINA1, MMP12, MMP8, ELANE

Biological processes related to Pulmonary Emphysema according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.8ELANE, SFTPD
2positive regulation of immune responseGO:0507789.6CTSG, ELANE
3negative regulation of growth of symbiont in hostGO:0441309.4ELANE, CTSG
4collagen catabolic processGO:0305749.3MMP12, MMP8, ELANE
5respiratory gaseous exchangeGO:0075859.3ELN, SFTPD
6response to lipopolysaccharideGO:0324969.1CTSG, ELANE, SERPINA1
7proteolysisGO:0065088.7CTSG, ELANE, MMP8, MMP12
8extracellular matrix disassemblyGO:0226178.3CTSG, ELN, ELANE, MMP8, MMP12
9extracellular matrix organizationGO:0301988.2MMP12, MMP8, ELANE, ELN, CTSG

Molecular functions related to Pulmonary Emphysema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:0041759.7ELANE, MMP12
2metalloendopeptidase activityGO:0042229.5MMP8, MMP12
3peptidase activityGO:0082339.4ELANE, CTSG
4protease bindingGO:0020209.4SERPINA1, ELANE
5serine-type endopeptidase activityGO:0042529.1CTSG, ELANE, MMP8

Products for genes affiliated with Pulmonary Emphysema

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Sources for Pulmonary Emphysema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet