Aliases & Classifications for Pulmonary Emphysema

MalaCards integrated aliases for Pulmonary Emphysema:

Name: Pulmonary Emphysema 37 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9675
ICD10 32 J43.8
ICD9CM 34 492.8

Summaries for Pulmonary Emphysema

MalaCards based summary : Pulmonary Emphysema is related to alpha-1-antitrypsin deficiency and bronchitis, and has symptoms including snoring, hemoptysis and coughing. An important gene associated with Pulmonary Emphysema is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Simvastatin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Pulmonary Emphysema

Diseases in the Pulmonary Emphysema family:

Emphysema, Hereditary Pulmonary

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 alpha-1-antitrypsin deficiency 32.6 ELANE ELN SERPINA1
2 bronchitis 30.6 ELANE SERPINA1 SERPINB1
3 vasculitis 30.1 ELANE SERPINA1 SERPINB1
4 pulmonary fibrosis 30.0 MMP9 SFTPD TIMP1
5 aortic aneurysm 29.8 ELN MMP9 TIMP1
6 pneumothorax 29.8 ELN HMOX1 MMP9 SERPINA1
7 interstitial lung disease 29.7 MMP9 SFTPD TIMP1
8 conjunctivochalasis 29.7 MMP1 TIMP1 TIMP2
9 wegener granulomatosis 29.7 ELANE ELN SERPINA1 SERPINB1
10 bronchiectasis 29.5 ELANE MMP8 SERPINA1
11 squamous cell carcinoma, head and neck 29.5 MMP1 MMP9 TIMP2
12 diffuse pulmonary fibrosis 29.5 SERPINA1 TIMP1
13 pulmonary disease, chronic obstructive 29.3 ELANE ELN HMOX1 MMP1 MMP12 SERPINA1
14 lung disease 29.0 ELANE ELN MMP9 SERPINA1 SERPINB1 SFTPD
15 pulmonary fibrosis, idiopathic 28.9 ELANE MMP1 MMP9 SFTPD TIMP1
16 periodontitis 28.8 ELANE MMP1 MMP8 MMP9 TIMP1
17 periodontal disease 28.4 ELANE MMP1 MMP8 MMP9 TIMP1 TIMP2
18 berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification 12.1
19 cutis laxa, autosomal recessive type 1 11.0
20 cerebral aneurysms 10.5 ELANE ELN
21 elephantiasis 10.5 ELANE ELN
22 senile ectropion 10.5 ELN MMP9
23 spastic entropion 10.5 MMP1 MMP9
24 erysipelas 10.4 ELANE ELN
25 gingival hypertrophy 10.4 MMP9 TIMP2
26 internal hemorrhoid 10.4 MMP1 MMP9
27 impetigo herpetiformis 10.4 ELANE SERPINB1
28 chromoblastomycosis 10.4 MMP1 MMP9
29 chronic venous leg ulcers 10.4 MMP9 TIMP1
30 adult astrocytic tumour 10.4 MMP1 MMP9
31 plasma protein metabolism disease 10.4 ELANE SERPINA1
32 cryptogenic organizing pneumonia 10.3 MMP9 TIMP1
33 conjunctival nevus 10.3 MMP9 TIMP1
34 chronic actinic dermatitis 10.3 ELN MMP1 MMP9
35 supravalvular aortic stenosis 10.3 ELN MMP9
36 odontogenic myxoma 10.3 MMP1 MMP9
37 lipodermatosclerosis 10.3 MMP1 TIMP2
38 pelvic organ prolapse 10.3 ELN MMP1 MMP9
39 aortic aneurysm, familial thoracic 1 10.3 ELN MMP1 MMP9
40 adenomyosis 10.2 MMP1 MMP9 TIMP2
41 amaurosis fugax 10.2 MMP8 MMP9
42 central nervous system tuberculosis 10.2 ELANE MMP9 TIMP1
43 kawasaki disease 10.2 ELANE MMP9 TIMP1
44 periodontosis 10.2 ELANE MMP9
45 periodontitis, chronic 10.2 MMP1 MMP8
46 microcystic meningioma 10.2 MMP9 TIMP1 TIMP2
47 tendinopathy 10.2 MMP1 MMP8
48 mycobacterium abscessus 10.2 HMOX1 SERPINA1
49 nasal cavity squamous cell carcinoma 10.2 MMP9 TIMP1 TIMP2
50 light chain deposition disease 10.2 MMP1 MMP12 MMP9

Comorbidity relations with Pulmonary Emphysema via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to Pulmonary Emphysema

Symptoms & Phenotypes for Pulmonary Emphysema

UMLS symptoms related to Pulmonary Emphysema:


snoring, hemoptysis, coughing

MGI Mouse Phenotypes related to Pulmonary Emphysema:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 SESN2 ELANE SFTPD HMOX1 TIMP1 ITGB6
2 hematopoietic system MP:0005397 9.91 SERPINB1 ELANE SFTPD HMOX1 TIMP1 ITGB6
3 immune system MP:0005387 9.7 ELANE SFTPD HMOX1 TIMP1 ITGB6 TIMP2
4 respiratory system MP:0005388 9.23 SESN2 SFTPD HMOX1 TIMP1 ITGB6 MMP12

Drugs & Therapeutics for Pulmonary Emphysema

Drugs for Pulmonary Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 257)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Budesonide Approved Phase 4,Phase 3 51333-22-3 5281004 63006
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
6
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
7
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
8
Losartan Approved Phase 4 114798-26-4 3961
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
12 tannic acid Approved, Nutraceutical Phase 4
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
14
Lactitol Investigational Phase 4 585-86-4 3871
15 Anesthetics Phase 4,Phase 2,Phase 1
16 Anticholesteremic Agents Phase 4
17 Antimetabolites Phase 4,Phase 1
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
19 Hypolipidemic Agents Phase 4,Phase 1
20 Lipid Regulating Agents Phase 4,Phase 1
21 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
22 Anti-Infective Agents Phase 4,Phase 3,Phase 1
23 Antimalarials Phase 4
24 Antiparasitic Agents Phase 4
25 Antiprotozoal Agents Phase 4
26 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
29 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
30 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33
Beclomethasone Phase 4,Phase 3 4419-39-0 20469
34 Bromides Phase 4,Phase 3,Phase 2
35 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 Cholinergic Agents Phase 4,Phase 2
37 Cholinergic Antagonists Phase 4,Phase 2
38 Formoterol Fumarate Phase 4,Phase 3,Phase 2
39 glucocorticoids Phase 4,Phase 3,Phase 1
40 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Parasympatholytics Phase 4,Phase 2
45 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Respiratory System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
47 Tiotropium Bromide Phase 4,Phase 2 136310-93-5
48 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
49
Salmeterol xinafoate Phase 4,Phase 3 94749-08-3 56801
50 Alpha 1-Antitrypsin Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 481)

# Name Status NCT ID Phase Drugs
1 AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation Unknown status NCT01460108 Phase 4
2 EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema Unknown status NCT00730301 Phase 4
3 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype Unknown status NCT01431625 Phase 4
4 Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
5 Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00857038 Phase 4 Doxycycline;Placebo
6 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4 Tiotropium + formoterol/beclometasone;tiotropium + placebo
7 Airway Clearance for Prevention of COPD Exacerbation Unknown status NCT00181207 Phase 4
8 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
9 Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography Unknown status NCT01361984 Phase 4 Nebulized arformoterol;Salmeterol
10 Small Airways Evaluation and Treatment Unknown status NCT02526758 Phase 4 beclomethasone;formoterol;budesonide
11 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
12 Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema Completed NCT00570544 Phase 4 tiotropium
13 Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency Completed NCT00261833 Phase 4
14 Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. Completed NCT00670007 Phase 4
15 Efficacy Study of the Effect of Budesonide on Emphysema Completed NCT00232674 Phase 4 Pulmicort (budesonide) Turbuhaler
16 Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients Completed NCT01336283 Phase 4
17 Efficacy of Losartan in Preventing Progression of COPD Completed NCT00720226 Phase 4 Losartan;Placebo
18 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00424528 Phase 4 Arformoterol Tartrate Inhalation Solution;Tiotropium;Arformoterol and Tiotropium;Placebo
19 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients Completed NCT00680056 Phase 4 Formoterol plus Placebo (Tiotropium);Formoterol plus Tiotropium
20 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis Completed NCT03073798 Phase 4 Roflumilast;Placebo
21 Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study Completed NCT01110200 Phase 4 ADVAIR DISKUS 250/50 mg BID;SEREVENT 50 mcg BID
22 Inhaled Steroid Reduces Systemic Inflammation in COPD Completed NCT00175565 Phase 4 inhaled fluticasone 500 mcg b.i.d.
23 Change of Inspiratory Peak Flow in COPD Completed NCT00561886 Phase 4 Formoterol
24 Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients Completed NCT02181023 Phase 4 Aclidinium Bromide;Glycopyrronium Bromide
25 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
26 Dynamic Hyperinflation and Tiotropium Completed NCT00569270 Phase 4 tiotropium;placebo;tiotropium
27 An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease Completed NCT00974805 Phase 4 Seretide 500 Accuhaler
28 Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD Completed NCT00571428 Phase 4 Arformoterol Tartrate Inhalation Solution;Arformoterol Tartrate Inhalation Solution;Placebo
29 Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD Completed NCT01745848 Phase 4 Roflumilast
30 A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00857766 Phase 4 ADVAIR DISKUS™ 250/50mcg
31 Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD Completed NCT02209974 Phase 4 Fluticasone;Inhaled Placebo
32 Costs & Outcomes of Hospitalization/Treatment With Levalbuterol & Albuterol in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Subjects Completed NCT00667797 Phase 4 levalbuterol HCl;albuterol Sulfate
33 Study of the Effect of the ROX AC1 on Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease (COPD) Patients Completed NCT00832611 Phase 4
34 Altitude Related Illness In Patients With Respiratory Disease Completed NCT02450968 Phase 4 Dexamethasone;Placebo
35 Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD Completed NCT01693003 Phase 4 Indacaterol;Tiotropium
36 Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude Completed NCT02450994 Phase 4 Dexamethasone;Placebo
37 Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00202189 Phase 4 Budesonide
38 GLASSIA Infusion Rate Study Completed NCT01651351 Phase 4
39 Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) Completed NCT00396006 Phase 4
40 Losartan Effects on Emphysema Progression Recruiting NCT02696564 Phase 4 Losartan;Placebo
41 Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema Recruiting NCT02682147 Phase 4 Sildenafil
42 Stage 1 Study of ARALAST NP and GLASSIA in A1PI Recruiting NCT02722304 Phase 4
43 RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD Recruiting NCT02989935 Phase 4
44 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep Recruiting NCT02150590 Phase 4 Oxygen;sham oxygen (room air)
45 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Exercise Performance Recruiting NCT02143609 Phase 4 oxygen;sham oxygen (room air)
46 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4 Low Dose Corticosteroids;High Dose Corticosteroids
47 Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease Recruiting NCT03156231 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
48 Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude Recruiting NCT03173508 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
49 Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude Recruiting NCT03177850 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
50 Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude Recruiting NCT03177837 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

Anatomical Context for Pulmonary Emphysema

MalaCards organs/tissues related to Pulmonary Emphysema:

38
Lung, Liver, Bone, Heart, Testes, Endothelial, Neutrophil

Publications for Pulmonary Emphysema

Articles related to Pulmonary Emphysema:

(show top 50) (show all 580)
# Title Authors Year
1
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA). ( 29357994 )
2018
2
Heterogeneity in pulmonary emphysema: Analysis of CT attenuation using Gaussian mixture model. ( 29444178 )
2018
3
Perception and Awareness of chronic obstructive pulmonary disease, Chronic Bronchitis and Pulmonary Emphysema in the Spanish Urban Population. ( 29428681 )
2018
4
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. ( 28186975 )
2017
5
Images in COPD: Combined Pulmonary Emphysema and Fibrosis with Pulmonary Hypertension. ( 28848914 )
2017
6
Prognostic Value of Radiation Pneumonitis After Stereotactic Body Radiotherapy: Effect of Pulmonary Emphysema Quantitated Using CTA Images. ( 28655592 )
2017
7
Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema. ( 28179328 )
2017
8
Bacteriological incidence in pneumonia patients with pulmonary emphysema: a bacterial floral analysis using the 16S ribosomal RNA gene in bronchoalveolar lavage fluid. ( 28790814 )
2017
9
The copper dependent-lysyl oxidases contribute to the pathogenesis of pulmonary emphysema in chronic obstructive pulmonary disease patients. ( 28965583 )
2017
10
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. ( 28807355 )
2017
11
Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy. ( 28584268 )
2017
12
Pulmonary emphysema is a predictor of pneumothorax after CT-guided transthoracic pulmonary biopsies of pulmonary nodules. ( 28574995 )
2017
13
Improvement of metabolic disorders by an EP(2) receptor agonist via restoration of the subcutaneous adipose tissue in pulmonary emphysema. ( 28263859 )
2017
14
Mild pulmonary emphysema a risk factor for interstitial lung disease when using cetuximab for squamous cell carcinoma of the head and neck. ( 28741444 )
2017
15
A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV. ( 28122034 )
2017
16
Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. ( 28894173 )
2017
17
Pulmonary Emphysema Cross-Linking with Pulmonary Fibrosis and Vice Versa: a Non-usual Experimental Intervention with Elastase and Bleomycin. ( 28534139 )
2017
18
Unsupervised Discovery of Spatially-Informed Lung Texture Patterns for Pulmonary Emphysema: The MESA COPD Study. ( 29354811 )
2017
19
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial. ( 28186686 )
2017
20
Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model. ( 27489022 )
2016
21
The Effect of Bone Marrow Mononuclear Cells on Lung Regeneration and Apoptosis in a Simple Model of Pulmonary Emphysema. ( 27426096 )
2016
22
Lung volume reduction of pulmonary emphysema: the radiologist task. ( 26807689 )
2016
23
Pulmonary Rehabilitation Improves Exercise Capacity And Molecular Skeletal Muscle Adaptation In Pulmonary Emphysema Patients: 2972 Board #37 June 3, 3: 30 PM - 5: 00 PM. ( 27361541 )
2016
24
Therapeutic Targeting of the IL-6 Trans-signalling/mTORC1 Axis in Pulmonary Emphysema. ( 27373892 )
2016
25
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
26
Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. ( 27382160 )
2016
27
Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens. ( 27445472 )
2016
28
Severity of pulmonary emphysema and lung cancer: analysis using quantitative lobar emphysema scoring. ( 27902611 )
2016
29
Acute pulmonary emphysema in death by hanging: a morphometric digital study. ( 27448112 )
2016
30
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model. ( 27644555 )
2016
31
Development of digital phantoms based on a finite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantification. ( 27838881 )
2016
32
Comparison of Serum Adiponectin in Smoke-induced Pulmonary Emphysema Rats Fed Different Diets. ( 26830990 )
2016
33
Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice. ( 27555760 )
2016
34
Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study. ( 27692154 )
2016
35
The Relationship of Educational Attainment with Pulmonary Emphysema and Airway Wall Thickness. ( 25822654 )
2015
36
Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats. ( 26515722 )
2015
37
Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice. ( 26160987 )
2015
38
Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis. ( 26636084 )
2015
39
Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. ( 26150711 )
2015
40
Pulmonary emphysema induced by methylphenidate: experimental study. ( 26018883 )
2015
41
Paratracheal air cysts: prevalence and relevance to pulmonary emphysema and bronchiectasis using thoracic multidetector CT. ( 25430529 )
2015
42
Development and analysis of a finite element model to simulate pulmonary emphysema in CT imaging. ( 26737750 )
2015
43
Lung Volume Reduction in Pulmonary Emphysema from the Radiologist's Perspective. ( 26062174 )
2015
44
Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. ( 25651034 )
2015
45
Pulmonary emphysema and tumor microenvironment in primary lung cancer. ( 26428090 )
2015
46
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis. ( 26180387 )
2015
47
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages. ( 25757189 )
2015
48
Different profiles of notch signaling in cigarette smoke-induced pulmonary emphysema and bleomycin-induced pulmonary fibrosis. ( 25813392 )
2015
49
Lung cancer, pulmonary emphysema and pleural effusion: An autopsy study. ( 26000874 )
2015
50
Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema? ( 25939639 )
2015

Variations for Pulmonary Emphysema

Expression for Pulmonary Emphysema

LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Emphysema patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 S100A12 S100 calcium binding protein A12 Lung - 3.38 0.026
2 SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Lung + 3.23 0.020
3 HLA-DOA major histocompatibility complex, class II, DO alpha Lung + 3.20 0.002
Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for Pulmonary Emphysema

Pathways related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 ELANE HMOX1 MMP1 MMP8 MMP9 SERPINA1
2
Show member pathways
13.11 ELN ITGB6 MMP1 MMP12 MMP8 MMP9
3
Show member pathways
12.26 ELANE ELN ITGB6 MMP1 MMP12 MMP8
4 11.95 MMP1 MMP12 MMP9
5
Show member pathways
11.95 ELN ITGB6 MMP1 MMP12 MMP8 MMP9
6 11.81 HMOX1 MMP1 MMP9 TIMP1
7 11.65 HMOX1 MMP9 TIMP1 TIMP2
8 11.52 ELN HMOX1 MMP9 SERPINA1 TIMP1
9 11.44 MMP1 MMP12 MMP9 TIMP1 TIMP2
10 11.18 HMOX1 MMP1 MMP9
11
Show member pathways
11.16 ELANE MMP1 MMP12 MMP8 MMP9 TIMP1
12 11.14 ELANE ELN MMP1 MMP9 TIMP2
13 11.01 MMP9 TIMP1 TIMP2
14 10.93 MMP9 TIMP2
15 10.8 MMP1 TIMP1
16 10.74 MMP1 MMP9

GO Terms for Pulmonary Emphysema

Cellular components related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 ELANE HMOX1 MMP12 MMP8 MMP9 SERPINA1
2 extracellular region GO:0005576 9.9 ELANE ELN MMP1 MMP12 MMP8 MMP9
3 ficolin-1-rich granule lumen GO:1904813 9.58 MMP9 SERPINA1 TIMP2
4 extracellular matrix GO:0031012 9.56 ELN MMP1 MMP12 MMP8 MMP9 SERPINB1
5 specific granule lumen GO:0035580 9.54 ELANE MMP8 TIMP2
6 tertiary granule lumen GO:1904724 9.5 MMP8 MMP9 TIMP2
7 proteinaceous extracellular matrix GO:0005578 9.28 ELN MMP1 MMP12 MMP8 MMP9 SERPINA1

Biological processes related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 ELANE MMP1 MMP12 MMP8 MMP9
2 cellular protein metabolic process GO:0044267 9.71 MMP1 SERPINA1 SFTPD TIMP1
3 neutrophil degranulation GO:0043312 9.63 ELANE MMP8 MMP9 SERPINA1 SERPINB1 TIMP2
4 negative regulation of endopeptidase activity GO:0010951 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
5 negative regulation of peptidase activity GO:0010466 9.56 SERPINA1 SERPINB1 TIMP1 TIMP2
6 cellular response to cadmium ion GO:0071276 9.51 HMOX1 MMP9
7 endodermal cell differentiation GO:0035987 9.49 MMP8 MMP9
8 positive regulation of macroautophagy GO:0016239 9.48 HMOX1 SESN2
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
10 negative regulation of metallopeptidase activity GO:1905049 9.37 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.26 MMP1 MMP12 MMP8 MMP9
12 extracellular matrix disassembly GO:0022617 9.23 ELANE ELN MMP1 MMP12 MMP8 MMP9

Molecular functions related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.88 MMP1 MMP12 MMP8 MMP9 TIMP1 TIMP2
2 peptidase activity GO:0008233 9.83 ELANE MMP1 MMP12 MMP8 MMP9
3 metallopeptidase activity GO:0008237 9.67 MMP1 MMP12 MMP8 MMP9
4 peptidase inhibitor activity GO:0030414 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
5 metalloendopeptidase activity GO:0004222 9.56 MMP1 MMP12 MMP8 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.46 TIMP1 TIMP2
7 protease binding GO:0002020 9.46 ELANE SERPINA1 TIMP1 TIMP2
8 serine-type endopeptidase activity GO:0004252 9.35 ELANE MMP1 MMP12 MMP8 MMP9
9 endopeptidase activity GO:0004175 8.92 ELANE MMP1 MMP12 MMP9

Sources for Pulmonary Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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