MCID: PLM035
MIFTS: 46

Pulmonary Eosinophilia malady

Respiratory diseases, Blood diseases categories
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Summaries for Pulmonary Eosinophilia

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MalaCards based summary: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to eosinophilia and asthma. An important gene associated with Pulmonary Eosinophilia is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are IL4-mediated signaling events and Selected targets of GCR alpha. The compounds mometasone furoate and levocabastine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone marrow, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Eosinophilia

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Pulmonary Eosinophilia, Aliases & Descriptions:

Name: Pulmonary Eosinophilia 8 44
 
Asthmatic Pulmonary Eosinophilia 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:9498
MeSH34 D011657
ICD9CM27 518.3
ICD1025 J82

Related Diseases for Pulmonary Eosinophilia

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Diseases related to Pulmonary Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia31.3RNASE3, EPX, CCL11, IL5
2asthma30.9IL5, EPX, RNASE3
3aspergillosis30.5SFTPD
4folliculitis30.4CCL11
5allergic bronchopulmonary aspergillosis30.3SFTPD, IL5
6interstitial lung disease30.2CCL11, SFTPD
7chronic eosinophilic pneumonia30.1RNASE3, CCL11, IL5
8bronchitis30.0RNASE3, CCL11, IL5
9bronchiolitis29.8IL5, CCL11, RNASE3
10pneumonia29.8SFTPD, EPX, CCL11, IL5
11sarcoidosis29.8SFTPD, CCL11
12allergic asthma29.5IL5, CCL11, EPX, RNASE3, SFTPD
13respiratory failure29.4CCL11, EPX, RNASE3, SFTPD
14paragonimiasis10.4IL5
15conjunctivitis10.4RNASE3
16filariasis10.4
17strongyloidiasis10.4IL5
18chronic rhinitis10.4RNASE3
19collagenous colitis10.4RNASE3
20carrington syndrome10.3
21pulmonary function10.3
22schistosomiasis10.2IL5, RNASE3
23helminthiasis10.2IL5, RNASE3
24intrinsic asthma10.2IL5, RNASE3
25kimura disease10.2RNASE3, IL5
26churg-strauss syndrome10.2RNASE3, IL5
27loeffler syndrome10.2
28pneumothorax10.2
29tuberculosis10.2
30angioedema10.1RNASE3, IL5
31proctitis10.1EPX, RNASE3
32eosinophilic gastroenteritis10.1CCL11, IL5
33eosinophilic esophagitis10.0CCL11, IL5
34adult respiratory distress syndrome10.0
35alpha 1-antitrypsin deficiency10.0
36hepatitis10.0
37pulmonary fibrosis10.0
38pulmonary tuberculosis10.0
39myelitis10.0
40miliary tuberculosis10.0
41sudden infant death syndrome10.0
42osteogenesis imperfecta10.0
43byssinosis10.0
44b cell deficiency10.0
45lipodystrophy10.0
46pericarditis10.0
47pneumoconiosis10.0
48vasculitis10.0
49cutaneous larva migrans10.0
50eosinophilic pustular folliculitis10.0

Graphical network of the top 20 diseases related to Pulmonary Eosinophilia:



Diseases related to pulmonary eosinophilia

Symptoms for Pulmonary Eosinophilia

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Drugs & Therapeutics for Pulmonary Eosinophilia

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Eosinophilia

Search NIH Clinical Center for Pulmonary Eosinophilia

Genetic Tests for Pulmonary Eosinophilia

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Anatomical Context for Pulmonary Eosinophilia

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MalaCards organs/tissues related to Pulmonary Eosinophilia:

32
Lung, T cells, Bone marrow, Bone, Heart, Breast, Testes, B cells

Animal Models for Pulmonary Eosinophilia or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Eosinophilia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7IL5, CCL11, SFTPD
2MP:00053978.0IL5, CCL11, EPX, SFTPD
3MP:00053877.8SFTPD, EPX, CCL11, IL5

Publications for Pulmonary Eosinophilia

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Articles related to Pulmonary Eosinophilia:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice. (23926350)
2013
2
Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia. (21808138)
2011
3
Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study. (21092270)
2010
4
Transient pulmonary eosinophilia incidentally found on low-dose computed tomography: findings in 40 individuals. (18303297)
2008
5
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma. (16730379)
2006
6
Elevated levels of fragmented laminin-5 gamma2-chain in bronchoalveolar lavage fluid from dogs with pulmonary eosinophilia. (16624727)
2006
7
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. (16374077)
2005
8
OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. (12794142)
2003
9
Pulmonary eosinophilia in mice devoid of interleukin-5. (12050181)
2002
10
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
11
Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia. (10529596)
1999
12
Pulmonary eosinophilia associated with montelukast. (10335014)
1999
13
Tropical pulmonary eosinophilia presenting as hydro-pneumothorax with broncho-pleural fistula. (10999107)
1999
14
Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. (9519215)
1998
15
5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. (9854052)
1998
16
Tropical pulmonary eosinophilia. Report of a case. (9515101)
1997
17
Recurrent post-partum pulmonary eosinophilia. (9516905)
1997
18
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
19
Characterization of the antigen-presenting cell and T cell requirements for induction of pulmonary eosinophilia in a murine model of asthma. (8938110)
1996
20
Syndrome resembling tropical pulmonary eosinophilia but of non-filarial aetiology: serological findings with filarial antigens. (8560543)
1995
21
Minocycline and pulmonary eosinophilia. (7787604)
1995
22
A case of tropical pulmonary eosinophilia. (7948545)
1994
23
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
24
Maloprim-induced pulmonary eosinophilia. (8417912)
1993
25
Tropical pulmonary eosinophilia in a 63-year-old woman from Guyana. (8324690)
1993
26
Pulmonary eosinophilia with systemic features: therapy and prognosis. (1470705)
1992
27
Pulmonary eosinophilia in pulmonary tuberculosis. (1600796)
1992
28
Correlation of lower respiratory tract inflammation with changes in lung function and chest roentgenograms in patients with untreated tropical pulmonary eosinophilia. (1876879)
1991
29
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
30
Rash and pulmonary eosinophilia associated with fenbufen. (2137356)
1990
31
Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex. (1698322)
1990
32
Corticosteroid treatment and prognosis in pulmonary eosinophilia. (2595633)
1989
33
Airway hyperreactivity in tropical pulmonary eosinophilia. (3359833)
1988
34
Pulmonary eosinophilia associated with cutaneous larva migrans. (3969661)
1985
35
Hepatic involvement in tropical pulmonary eosinophilia. (6501178)
1984
36
Tropical pulmonary eosinophilia: an unusual presentation. (6618529)
1983
37
Epidemiology of bancroftian filariasis in East Godavari district (Andhra Pradesh)--incidence of tropical pulmonary eosinophilia. (7040222)
1981
38
Lipodystrophy and pulmonary eosinophilia. (7228604)
1981
39
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
40
Immunoglobulins in byssinosis, chronic bronchitis and pulmonary eosinophilia. (730695)
1978
41
Pulmonary eosinophilia. Netaji oration. Part II. (730723)
1978
42
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
43
Cytophilic antibodies in bronchopulmonary aspergilloma and cryptogenic pulmonary eosinophilia. (63346)
1976
44
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
45
Leukocyte adhesion phenomenon in pulmonary eosinophilia (tropical eosinophilia). (4683591)
1973
46
PRELIMINARY STUDIES ON THE PRODUCTION OF EXPERIMENTAL PULMONARY EOSINOPHILIA BY TISSUE ANTIGEN ANTIBODY REACTION OF THE HOST. (14235491)
1964
47
Pulmonary eosinophilia; report of a case. (13413195)
1957
48
Prolonged pulmonary eosinophilia; a report on three cases. (14363706)
1955
49
Myelitis following arsenic therapy in pulmonary eosinophilia. (13017551)
1952
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Variations for Pulmonary Eosinophilia

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Expression for genes affiliated with Pulmonary Eosinophilia

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Expression patterns in normal tissues for genes affiliated with Pulmonary Eosinophilia

Search GEO for disease gene expression data for Pulmonary Eosinophilia.

Pathways for genes affiliated with Pulmonary Eosinophilia

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Pathways related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CCL11, IL5
29.2CCL11, IL5
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1CCL11, SFTPD
4
Show member pathways
8.1IL5, CCL11, EPX, RNASE3

Compounds for genes affiliated with Pulmonary Eosinophilia

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Compounds related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1mometasone furoate44 6110.8RNASE3, IL5
2levocabastine44 28 1111.8IL5, RNASE3
3beclomethasone dipropionate449.8IL5, RNASE3
4toluene diisocyanate449.8RNASE3, IL5
5nedocromil sodium449.8RNASE3, IL5
6praziquantel44 1110.7RNASE3, IL5
7tele-methylhistamine449.7EPX, RNASE3
8azelastine44 1110.6IL5, RNASE3
9ltd4449.6IL5, RNASE3
10sephadex449.6EPX, RNASE3
115-oxoete449.5IL5, CCL11
12anti-histamine449.4CCL11, RNASE3
13roxithromycin44 28 1111.4CCL11, IL5
14anti-fungal449.4IL5, RNASE3, SFTPD
15theophylline44 28 24 1112.2RNASE3, EPX, IL5
16p005449.2EPX, RNASE3, SFTPD
17clarithromycin44 1110.2CCL11, IL5
18percoll449.2RNASE3, IL5
19unicap449.1IL5, CCL11, RNASE3
20pranlukast44 28 1111.1RNASE3, CCL11, IL5
21montelukast44 50 28 1112.1RNASE3, CCL11, IL5
22fluticasone propionate44 50 61 1112.1IL5, CCL11, RNASE3
23methacholine44 50 1111.1IL5, CCL11, RNASE3
24n-formylmethionyl-leucylphenylalanine449.1RNASE3, CCL11, IL5
25rolipram44 61 2811.0EPX, CCL11, IL5
26endotoxin448.9SFTPD, RNASE3, CCL11
27rantes448.9IL5, CCL11, RNASE3
28dithiothreitol448.9CCL11, EPX, RNASE3
29butyrate448.7IL5, CCL11, EPX
30cyclosporin a44 28 6110.7IL5, CCL11, RNASE3
31sodium cromoglycate448.5RNASE3, EPX, CCL11, IL5
32lte4448.5RNASE3, EPX, CCL11, IL5
33cetirizine44 28 24 1111.5RNASE3, EPX, CCL11, IL5
34salmeterol44 50 28 1111.5RNASE3, EPX, CCL11, IL5
35ketotifen44 119.5RNASE3, EPX, CCL11, IL5
36ltc4448.5RNASE3, EPX, CCL11, IL5
37salbutamol44 50 28 24 1112.5RNASE3, EPX, CCL11, IL5
38pgd2448.5IL5, CCL11, EPX, RNASE3
39leukotriene b444 61 2410.5RNASE3, EPX, CCL11, IL5
40fmlp448.5IL5, CCL11, EPX, RNASE3
41pge2448.4IL5, CCL11, EPX, RNASE3
42heparin44 28 24 1111.4RNASE3, EPX, CCL11, IL5
43steroid448.3SFTPD, RNASE3, EPX, CCL11
44nitric oxide44 24 1110.3CCL11, EPX, RNASE3, SFTPD
45budesonide44 50 1110.0IL5, CCL11, EPX, RNASE3, SFTPD
46allergens448.0SFTPD, RNASE3, EPX, CCL11, IL5
47prednisolone44 28 1110.0SFTPD, RNASE3, EPX, CCL11, IL5
48histamine44 28 2410.0SFTPD, RNASE3, EPX, CCL11, IL5
49dexamethasone44 50 28 1110.9SFTPD, RNASE3, EPX, CCL11, IL5
50lipid447.9CCL11, EPX, RNASE3, SFTPD

GO Terms for genes affiliated with Pulmonary Eosinophilia

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Cellular components related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7IL5, CCL11, SFTPD
2extracellular regionGO:0055767.9IL5, CCL11, RNASE3, SFTPD

Biological processes related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.4RNASE3, SFTPD

Products for genes affiliated with Pulmonary Eosinophilia

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Sources for Pulmonary Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet