MCID: PLM035
MIFTS: 51

Pulmonary Eosinophilia malady

Respiratory diseases category

Summaries for Pulmonary Eosinophilia

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MalaCards: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to eosinophilia and asthma. An important gene associated with Pulmonary Eosinophilia is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are OX40 Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Eosinophilia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary eosinophilia 8 44
asthmatic pulmonary eosinophilia 60


External Ids:

Disease Ontology8 DOID:9498
MeSH34 D011657
ICD9CM27 518.3
ICD1025 J82

Related Diseases for Pulmonary Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia31.7IL8, IL4, IL5, IL3, IL13, RNASE2
2asthma30.8IL13, CCL11
3filariasis30.5IL5, IL13, IGHE
4allergic asthma30.3IL8, IL4, IL5, IL3, IL13, RNASE3
5pneumonia30.2SERPINA1, IL8, IL5, IL13, EPX, PDE4A
6chronic eosinophilic pneumonia30.1IL5, RNASE3, CCL11
7interstitial lung disease30.1IL8, SFTPD, CCL3, CCL17, CCL11
8tuberculosis30.1SERPINA1, IL4, EPX, SFTPD, CCL7, CCL3
9bronchitis30.1SERPINA1, IL8, IL5, RNASE3, IGHE, CCR3
10folliculitis29.9CCL11
11aspergillosis29.9SFTPD, CCL3
12alpha 1-antitrypsin deficiency29.9SERPINA1
13respiratory failure29.9SERPINA1, SFTPD
14sarcoidosis29.9IL13, SFTPD, CCL3, CCL11
15allergic bronchopulmonary aspergillosis29.9IL4, IL5, IGHE, SFTPD
16hepatitis29.9SERPINA1, GGT1, CCL11
17vasculitis29.9SERPINA1, CYSLTR1, PRG2
18bronchiolitis29.9IL8, IL5, IL13, RNASE3, IGHE, CCL3
19pulmonary fibrosis29.9IL8, IL13, CYSLTR1, PRG2, SFTPD, CCL3
20eosinophilic pneumonia29.9IL5, IL3, IL13, RNASE3, IGHE, CCL17
21carrington syndrome10.2
22pulmonary tuberculosis10.1
23loeffler syndrome10.1
24pneumothorax10.1
25endocarditis10.0EPX
26pleurisy10.0PDE4A
27ischemia10.0EPX
28acquired immunodeficiency syndrome10.0CCR3
29dermatitis herpetiformis10.0CCL11
30malignant glioma10.0IL13
31coronary heart disease10.0GGT1
32toxic shock syndrome10.0CCL3
33periodontitis10.0IL8
34dementia10.0CCR3
35multiple myeloma10.0CCL3
36meningitis10.0IL8
37bronchiolitis obliterans10.0IL8
38migraine10.0RNASE2
39hypertension10.0GGT1
40common variable immune deficiency10.0IL4
41cholangitis10.0GGT1
42chronic rhinitis10.0RNASE3
43influenza10.0SFTPD, CCL11
44corneal ulcer10.0PRG2, CCL11
45uveitis10.0IL4, CCL11
46myocardial infarction10.0CCL3, CCL11
47proctitis10.0RNASE3, EPX
48conjunctivitis10.0RNASE3, IGHE
49synovitis10.0IL8
50proteinuria10.0GGT1

Graphical network of the top 20 diseases related to Pulmonary Eosinophilia:



Diseases related to pulmonary eosinophilia

Clinical Features for Pulmonary Eosinophilia

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Drugs & Therapeutics for Pulmonary Eosinophilia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Pulmonary Eosinophilia

Search NIH Clinical Center for Pulmonary Eosinophilia

Search CenterWatch for Pulmonary Eosinophilia

Genetic Tests for Pulmonary Eosinophilia

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Anatomical Context for Pulmonary Eosinophilia

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Eosinophilia:

32
Lung, T cells, Bone, Bone marrow, Testes, Heart, Breast, B cells

Animal Models for Pulmonary Eosinophilia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Eosinophilia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5CYSLTR1, PRG2, SFTPD, CCL11
2MP:00053976.2PRG2, SFTPD, CCL7, CCR3, CCL3, CCL11
3MP:00053875.5GGT1, CCL11, CCL17, CCL3, CCR3, CCL7

Publications for Pulmonary Eosinophilia

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50PubMed
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Articles related to Pulmonary Eosinophilia:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
A rare case of ethambutol induced pulmonary eosinophilia. (24250213)
2013
2
Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia. (22252873)
2012
3
Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia. (22131646)
2011
4
Pulmonary cryptococcosis with severe eosinophilia in an immunocompetent patient. (21123163)
2010
5
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. (18242596)
2008
6
Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. (17620002)
2007
7
Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice. (15501700)
2004
8
Tropical pulmonary eosinophilia: a case series in a setting of nonendemicity. (15486834)
2004
9
Pulmonary eosinophilia following lung transplantation for sarcoidosis in two patients. (12576393)
2003
10
Suppression of allergen reactive Th2 mediated responses and pulmonary eosinophilia by intranasal administration of an immunodominant peptide is linked to IL-10 production. (12531655)
2003
11
Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists. (11961081)
2002
12
Gq signaling is required for allergen-induced pulmonary eosinophilia. (11907117)
2002
13
Respiratory syncytial virus infection of gene gun vaccinated mice induces Th2-driven pulmonary eosinophilia even in the absence of sensitisation to the fusion (F) or attachment (G) protein. (11137237)
2000
14
Re-examination of the diagnostic criteria of tropical pulmonary eosinophilia. (10542980)
1999
15
Interleukin-12 suppresses filaria-induced pulmonary eosinophilia, deposition of major basic protein and airway hyperresponsiveness. (9797506)
1998
16
Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus. (9815273)
1998
17
Recurrent post-partum pulmonary eosinophilia. (9516905)
1997
18
Pulmonary eosinophilia. (12521088)
1997
19
Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines. (9032176)
1997
20
Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. (9236194)
1997
21
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
22
Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig. (8638729)
1996
23
Syndrome resembling tropical pulmonary eosinophilia but of non-filarial aetiology: serological findings with filarial antigens. (8560543)
1995
24
Mast cells modulate allergic pulmonary eosinophilia in mice. (7695919)
1995
25
Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5. (7613159)
1995
26
Tropical pulmonary eosinophilia in a 63-year-old woman from Guyana. (8324690)
1993
27
Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex. (1698322)
1990
28
The BALB/c mouse as a model for immunological studies of microfilariae-induced pulmonary eosinophilia. (2382764)
1990
29
Cryptogenic pulmonary eosinophilia--a case report. (2281365)
1990
30
Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine. (2173455)
1990
31
Tropical pulmonary eosinophilia in permanent residents of Punjab. (2807420)
1989
32
Pulmonary eosinophilia with and without allergic bronchopulmonary aspergillosis. (2595632)
1989
33
Ventilatory functions in tropical pulmonary eosinophilia. (2636584)
1989
34
Pulmonary eosinophilia. (3712300)
1986
35
Spontaneous pneumothorax in tropical pulmonary eosinophilia. (4078330)
1985
36
Anti-filarial IgG antibodies in patients with bancroftian filariasis and tropical pulmonary eosinophilia. (3914453)
1985
37
Persisting "asthma" in tropical pulmonary eosinophilia. (6740545)
1984
38
Unusual presentation of tropical pulmonary eosinophilia. (6474395)
1984
39
Pulmonary eosinophilia caused by penicillamine. (7268676)
1980
40
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
41
Immunoglobulins in byssinosis, chronic bronchitis and pulmonary eosinophilia. (730695)
1978
42
Agar gel electrophoretic serum protein pattern in tropical pulmonary eosinophilia. (608694)
1977
43
Cryptogenic pulmonary eosinophilia. (58741)
1976
44
Intradermal and gel-diffusion tests with dirofilarial antigens in tropical pulmonary eosinophilia. (829121)
1976
45
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
46
Cytoplasmic vacuoles of eosinophils in tropical pulmonary eosinophilia. (4746596)
1973
47
Tropical pulmonary eosinophilia in children. (4781018)
1973
48
Tropical pulmonary eosinophilia. (5101086)
1971
49
Study of clinical, radiological and pulmonary function patterns of response to treatment in pulmonary eosinophilia. (5520230)
1970
50
Pulmonary eosinophilia; report of a case. (13413195)
1957

Genetic Variations for Pulmonary Eosinophilia

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Expression for genes affiliated with Pulmonary Eosinophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Eosinophilia

Search GEO for disease gene expression data for Pulmonary Eosinophilia.

Pathways for genes affiliated with Pulmonary Eosinophilia

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Sources:
51QIAGEN, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 53Reactome
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Pathways related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL13, IL4, IL5
29.9IL5, IL13, IL4
39.8IL8, IL4, CCL11
4
Hide members
9.8GGT1, CYSLTR1
59.8IL4, IL5, IL3
69.6CCL11, IL5, IL4, IL8
79.6IL8, IL13, IL4, IL5
8
Immune response CCR3 signaling in eosinophils
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9.6CCL11, CCR3, CCL7, IL8
99.5IL4, IL5, IL3, IL13
10
Hide members
9.5IL8, IL4, IL5, IL3
119.3IL13, IL5, IL4, IL3, IL8
129.2CCL3, SERPINA1, PRG2, SFTPD
139.1IL4, IL5, CCL17, CCL11, IGHE
14
Hide members
8.9CCL7, IL8, CCR3, CCL11, CCL17, CCL3
158.9IL8, CCR3, CCL11, CCL17, CCL3, CCL7
16
Hide members
8.8IL5, IL13, IGHE, CCL11, IL4, IL3
17
Hide members
8.8CCL3, CCR3, CCL7, IL5, PRG2, CCL17
18
Hide members
8.6CCL3, CCL11, CCL17, IL8, CYSLTR1, CCL7
19
Hide members
8.6PRG2, CCL11, EPX, RNASE3, IL4, IL5
20
Hide members
8.5CCL17, CCL11, CCL3, CCR3, CCL7, PRG2
21
Hide members
8.4CCL7, CCR3, CCL3, CCL17, CCL11, IL13
22
Hide members
8.2IL8, PDE4A, CCL17, CCR3, CCL11, CCL3
23
Hide members
8.1IL13, IL5, CCL11, CCL17, CCL3, CCL7
24
Hide members
7.9IL5, IL4, IL8, IL3, IL13, CCL7
25
Hide members
7.9CCL11, CCL17, CCL3, CCR3, IL8, IL4

Compounds for genes affiliated with Pulmonary Eosinophilia

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.3EPX, PDE4A
2hydrocortisone44 2 59 1112.9IL8, IGHE
3indomethacin44 59 28 1112.9IL5, GGT1, PRG2
4pge2449.8PDE4A, CCL11, CYSLTR1, EPX
5pranlukast44 28 1111.7CCL11, CYSLTR1, RNASE3, IL5, IL4
6formoterol44 28 1111.6IL13, RNASE3, PDE4A, IL4, IL8
7sodium cromoglycate449.5IGHE, EPX, IL5, RNASE3, CCL11
8mcp 1449.5CCR3, CCL7, IL5, IL8, CCL3
9lte4449.4CCL11, GGT1, IL5, CYSLTR1, RNASE3, EPX
10cetirizine44 28 11 2412.4IGHE, CCL11, IL8, IL5, RNASE3, EPX
11omalizumab44 1110.3IL5, IGHE, IL13, IL4
12mip 1alpha449.3IL3, IL8, IL4, IL13, CCL3
13rantes449.3IL3, IL4, RNASE3, CCL7, CCL3, CCL11
14azelastine44 1110.2RNASE3, IL3, IL5, IL4, IGHE
15nedocromil sodium449.2IL4, IL8, IL5, IL3, RNASE3, IGHE
16ketotifen44 1110.2IL5, RNASE3, EPX, IGHE, CCL11, PDE4A
17h2o2449.2IL13, EPX, IL3, CCL3, PDE4A
18anaphylatoxin449.2CCL7, IL3, IL4, CCL3, IL8, RNASE3
19poly(i-c)449.2IL4, IL8, IL3, CCL3, CCL11, IL5
20unicap449.1IGHE, RNASE3, IL5, CCL11
21fluticasone propionate44 49 59 1112.1IL4, IL13, RNASE3, IL8, CCL11, IGHE
22salmeterol44 49 28 1112.1IL4, IL8, IL5, IL13, RNASE3, CCL11
23ltd4449.1GGT1, IL5, CCR3, CYSLTR1, RNASE3, IL13
24praziquantel44 1110.1IL5, IL4, GGT1, IL13, RNASE3, IGHE
25ccl444 2810.0CCL11, IL13, CCL7, CCR3, CCL3, CCL17
26ccl344 2810.0CCL11, CCL17, CCL3, CCR3, CCL7, IL13
27il 10449.0CCL3, IL4, IL3, IL5, CCL17, IL8
28montelukast44 49 28 1111.9CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
29prednisolone44 28 1110.7IGHE, SFTPD, CCL11, CCL3, EPX, RNASE3
30pgd2448.6IL5, IL13, CCL11, CCR3, PRG2, IGHE
31heparin44 28 11 2411.6RNASE3, PRG2, CCR3, CCL3, CCL11, EPX
32ltc4448.6PRG2, EPX, CYSLTR1, RNASE3, IL13, IL3
33salbutamol44 49 28 11 2412.5CCL11, PDE4A, IGHE, EPX, CYSLTR1, RNASE3
34tacrolimus44 49 1110.5CCL11, CCL17, CCL3, IL4, GGT1, IL5
35methacholine44 119.4IL8, CCL11, CCL3, PRG2, IGHE, RNASE3
36allergens448.4PRG2, IGHE, EPX, RNASE3, IL13, IL5
37budesonide44 49 1110.4CCL11, SFTPD, PDE4A, IGHE, EPX, RNASE3
38tarc448.2CCL11, CCL17, CCL3, CCR3, CCL7, IGHE
39thymidine44 249.1SERPINA1, CCL3, CCR3, SFTPD, CCL11, IL13
40leukotriene b444 59 2410.1CCL3, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
41fmlp448.0CCL11, CCL3, CCL7, PDE4A, PRG2, EPX
42polysaccharide447.9SERPINA1, GGT1, IL3, IGHE, CCL3, SFTPD
43lactate447.8SFTPD, IL8, IGHE, IL3, IL13, RNASE3
44nitric oxide44 11 249.8SFTPD, EPX, PRG2, RNASE3, PDE4A, IL13
45cyclosporin a44 28 599.7IL5, CCL11, CCL17, RNASE3, IGHE, PDE4A
46actinomycin d447.5CCL11, CCL3, CCR3, CCL7, PDE4A, PRG2
47cysteine447.5CCL3, CCR3, SFTPD, PRG2, EPX, IL3
48tyrosine447.3RNASE3, SERPINA1, IL4, PDE4A, IL5, CYSLTR1
49histamine44 28 248.6CCR3, CCL7, SFTPD, PDE4A, PRG2, IGHE
50dexamethasone44 49 28 119.2CCL7, SFTPD, PDE4A, EPX, CYSLTR1, RNASE3

GO Terms for genes affiliated with Pulmonary Eosinophilia

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16Gene Ontology
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Cellular components related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CCL17, CCL3, CCR3, CCL7, SFTPD, IL13
2extracellular regionGO:0055765.9SERPINA1, CCL11, CCL17, CCL3, CCL7, SFTPD

Biological processes related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCL11, CCR3
2regulation of proton transportGO:01015510.1IL13, IL4
3positive regulation of B cell proliferationGO:03089010.0IL4, IL5, IL13
4positive regulation of natural killer cell chemotaxisGO:20005039.9CCL3, CCL7
5positive regulation of angiogenesisGO:0457669.7CCL11, CCR3, CYSLTR1
6eosinophil chemotaxisGO:0482459.6CCL11, CCL3, CCR3, CCL7
7cellular calcium ion homeostasisGO:0068749.6CCL7, CCL3, CCL11
8cytoskeleton organizationGO:0070109.6CCL7, CCL3, CCL11
9macrophage chemotaxisGO:0482469.6SFTPD, CCL3
10cell-cell signalingGO:0072679.2CCL17, CCL3, CCL7, IL13, IL3
11inflammatory responseGO:0069548.5CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
12chemotaxisGO:0069358.3CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
13immune responseGO:0069558.0IL8, CCL11, CCL17, CCL7, PRG2, IGHE

Molecular functions related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.7CCL7, CCL3
2pancreatic ribonuclease activityGO:0045229.7RNASE2, RNASE3
3cytokine activityGO:0051259.5IL13, IL3, IL5, IL4
4ribonuclease activityGO:0045409.4RNASE2, RNASE3
5chemokine activityGO:0080099.2IL8, CCL7, CCL3, CCL17, CCL11

Products for genes affiliated with Pulmonary Eosinophilia

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  • Antibodies
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Sources for Pulmonary Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet