Pulmonary Eosinophilia malady

MalaCards: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to chronic eosinophilic pneumonia and b cell deficiency. An important gene associated with Pulmonary Eosinophilia is PRG2 (proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)), and among its related pathways are Fc epsilon RI signaling pathway and Selected targets of GCR-alpha. The compounds endotoxin and formoterol have been mentioned in the context of this disorder. Affiliated tissues include lung and b cells, and related mouse phenotypes are respiratory system and immune system.

Aliases & Descriptions:

pulmonary eosinophilia 6 32 asthmatic pulmonary eosinophilia 43

Diseases related to pulmonary eosinophilia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 411)

id	Related Disease	Score	Top Affiliating Genes
1	chronic eosinophilic pneumonia	30.6	IL5, CCL11, RNASE3
2	b cell deficiency	28.4	IL4, IL5, CCL7, IGHE
3	filariasis	27.5	IL13, IL4, IL5, IGHE, IFNG, GGT1
4	t cell deficiency	27.3	IL4, IL5, CCL7, CCL3, IGHE, IFNG
5	eosinophilia	24.7	PDE4A, SFTPD, SERPINA1, IL13, IL3, IL4
6	pneumonia	21.4	PDE4A, SFTPD, SERPINA1, IL13, IL3, IL4
7	giant papillary conjunctivitis	13.6	CCL11, PRG2
8	papillary conjunctivitis	13.6	CCL11, PRG2
9	dermatographia	13.6	IGHE, PRG2
10	asthma	13.5	PDE4A, RNASE3
11	corneal ulcer	13.5	CCL11, CCR3, PRG2
12	chronic rhinitis	13.5	RNASE3, EPX
13	intestinal schistosomiasis	13.4	IL13, IL5
14	anisakiasis	13.4	IGHE, RNASE3
15	exanthem	13.4	IL5, CCL11
16	toxocariasis	13.4	IGHE, RNASE3
17	poems syndrome	13.4	IL5, CCL11, CCL3
18	chromoblastomycosis	13.4	IL4, CCL3
19	respiratory syncytial virus infectious disease	13.3	IL13, IL5, CCL3
20	proctitis	13.3	IL8, RNASE3, EPX
21	bagassosis	13.3	IL5, IL8
22	eosinophilic meningitis	13.3	IL4, IL5
23	extrinsic allergic alveolitis	13.3	SFTPD, IL8, CCL3
24	egg allergy	13.3	IL4, IL5, IGHE
25	dermatitis herpetiformis	13.3	IL13, IL5, CCL11
26	alcoholic hepatitis	13.3	IL8, CCL3, GGT1
27	angiostrongyliasis	13.2	IL13, IL4, IL5
28	ocular cicatricial pemphigoid	13.2	IL4, IL5, RNASE3, PRG2
29	idiopathic interstitial pneumonia	13.2	SFTPD, IL13, IL8
30	hepatic tuberculosis	13.2	SERPINA1, GGT1
31	eosinophilic fasciitis	13.2	IL5, IFNG
32	status asthmaticus	13.1	IL5, IL8, CCL11, RNASE3
33	diffuse panbronchiolitis	13.1	IL13, IL5, IL8
34	panbronchiolitis	13.1	IL13, IL5, IL8
35	common cold	13.1	IL5, IL8, CCL11, RNASE3
36	chondroblastoma	13.1	IL4, IL5, IL8
37	paranasal sinus disease	13.1	IL5, IFNG
38	classic kaposi sarcoma	13.1	IL13, IL4, IL8
39	helminthiasis	13.1	IL13, IL5, IGHE, RNASE3
40	localized scleroderma	13.1	IL13, IL4, IL8
41	cough variant asthma	13.1	IL4, IL5, IGHE, RNASE3
42	allergic bronchopulmonary aspergillosis	13.1	SFTPD, IL4, IL5, IGHE
43	gastroesophageal reflux disease	13.1	IL5, IL8, CCL11, CCR3
44	multifocal motor neuropathy	13.1	IL4, IFNG
45	eosinophilic gastroenteritis	13.0	IL5, CCL11, IGHE, RNASE3, PRG2
46	african tick-bite fever	13.0	IL13, CCL3, IFNG
47	silicosis	13.0	SFTPD, IL5, IL8
48	fascioliasis	13.0	IFNG, RNASE3, GGT1
49	lepromatous leprosy	13.0	IL4, IFNG
50	pleural tuberculosis	13.0	IL4, IFNG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pulmonary eosinophilia:

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MGI Mouse Phenotypes related to pulmonary eosinophilia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.3	PRG2, CYSLTR1, SFTPD
2	immune system phenotype	MP:0005387	8.0	PDE4A, GGT1, CSF2, CYSLTR1, IFNG, CCL3
3	hematopoietic system phenotype	MP:0005397	7.2	EPX, CSF2, PRG2, IGHE, CCR3, CCL11
4	homeostasis/metabolism phenotype	MP:0005376	6.5	CSF2, IFNG, IGHE, CCL3, CCR3, IL5

Articles related to pulmonary eosinophilia:

(show all 16)

id	Title	Authors	Year	Affiliating Genes
1	Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia. (17996260)	RiihimAoki M.... Pringle J.	2008	IL4, IL5
2	Tropical pulmonary eosinophilia: pathogenesis, diagnosis and management. (17940489)	Vijayan V.K.	2007	IL4
3	Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (16014847)	Kim Y.J.... Nutman T.B.	2005	RNASE2, RNASE3
4	Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia. (12595450)	O'Bryan L.... Nutman T.B.	2003	CSF2, IL13, IL5
5	Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity. (12540554)	Lobos E.... Moncada S.	2003	GGT1
6	A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. (12750406)	Katoh S.... Matsukura S.	2003	CCL11, CCL17
7	Pulmonary eosinophilia and production of MIP-1alpha are prominent responses to infection with pneumonia virus of mice. (10753501)	Domachowske J.B.... Rosenberg H.F.	2000	CCL3, IL5
8	Pulmonary eosinophilia associated with montelukast. (10335014)	Franco J.... Artes M.J.	1999	CYSLTR1
9	Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. (10030835)	MacLean J.A.... De Sanctis G.T.	1999	IL4, CCL7, IL5
10	Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. (9802959)	Dent G.... Rabe K.F.	1998	PDE4A
11	Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines. (9032176)	Shaver J.R.... Peters S.P.	1997	RNASE3
12	Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)	Rothenberg M.E.... Luster A.D.	1996	CCL11, IL5
13	Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5. (7613159)	Egan R.W.... Bodmer M.W.	1995	IL5
14	Alpha 1-antitrypsin in tropical pulmonary eosinophilia. (8339638)	Ray D.... Sri Krishna K.	1993	SERPINA1
15	The BALB/c mouse as a model for immunological studies of microfilariae-induced pulmonary eosinophilia. (2382764)	Egwang T.G.... Kazura J.W.	1990	IGHE
16	Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132. (2210871)	Kings M.A.... Morley J.	1990	IL3, IFNG

Genes related to pulmonary eosinophilia according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0
2	EPX	eosinophil peroxidase	11.0
3	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
4	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
5	SFTPD	surfactant protein D	11.0
6	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
7	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
8	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
9	GGT1	gamma-glutamyltransferase 1	11.0	Publications
10	CCR3	chemokine (C-C motif) receptor 3	11.0
11	IL4	interleukin 4	11.0	Publications
12	IL13	interleukin 13	11.0	Publications
13	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
14	IL8	interleukin 8	11.0
15	RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	11.0	Publications
16	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
17	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
18	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Publications
19	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
20	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
21	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
22	IFNG	interferon, gamma	11.0	Publications

Pathways related to pulmonary eosinophilia according to GeneDecks:

(show top 50)    (show all 51)

id	Pathway	Score	Top Affiliating Genes
1	Fc epsilon RI signaling pathway20	10.5	IL4
2	Selected targets of GCR-alpha10	10.5	IL4
3	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.4	CCL11
4	Bacterial infections in CF airways41	10.2	SFTPD
5	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	IL13, IL4, IL5
6	Immune response_CD16 signaling in NK cells41	9.8	CSF2
7	Leukotriene modifiers pathway, Pharmacodynamics34	9.8	CYSLTR1, GGT1
8	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	CCL3, CSF2
9	Immune response_TLR signaling pathways41	9.7	CCL11, IL8, IL4
10	Selected targets of C/EBPbeta10	9.7	PRG2, CCL3, SERPINA1, SFTPD
11	Allograft rejection20	9.6	IFNG, IL5, IL4
12	Immune response IL-4 signaling pathway10	9.6	IL4, IGHE
13	OX40 Pathway36	9.5	IL13, IL4, IL5, IFNG
14	Class A/1 (Rhodopsin-like receptors)38	9.3	CCL3, CCR3, CCL17, CCL11, CCL7
15	JNK Pathway36	9.2	CCL3, CCL11, CCL7, IL3
16	Chemokine Signaling36	9.1	CCL3, CCR3, CCL17, CCL11, CCL7, IL8
17	Chemokine signaling pathway20	9.0	IL8, CCL7, CCL11, CCL17, CCR3, CCL3
18	T cell receptor signaling pathway20	8.9	CSF2, IFNG, IL5, IL4
19	Transendothelial Migration of Leukocytes36	8.8	PRG2, CCL3, CCR3, CCL17, CCL11, CCL7
20	Rheumatoid arthritis20	8.8	CSF2, IFNG, CCL3, IL8
21	Asthma20	8.8	EPX, PRG2, RNASE3, CCL11, IL5, IL4
22	Hematopoietic cell lineage20	8.8	CSF2, IL5, IL4, IL3
23	Cytokine Network36	8.6	IFNG, IL8, IL5, IL4, IL3, IL13
24	Immune response CD16 signaling in NK cells10	8.4	CSF2, IFNG, IL4, IL3
25	Akt Signaling36	8.3	CSF2, CCL3, CCR3, CCL17, CCL11, CCL7
26	RAR-Gamma-RXR-Alpha Degradation36	8.3	CSF2, CCL3, CCL17, CCL11, CCL7, IL3
27	Jak-STAT signaling pathway20	8.1	CSF2, IFNG, IL5, IL4, IL3, IL13
28	NFAT Signaling and Lymphocyte Interactions36	8.0	CCL3, CCL17, CCL11, CCL7, IL8, IL5
29	PGC1Alpha Pathway36	8.0	CCL3, CCL17, CCL11, CCL7, IL8, IL5
30	SOCS Pathway36	8.0	CCL3, CCL17, CCL11, CCL7, IL8, IL5
31	Regulation of eIF4 and p70S6K36	8.0	CCL3, CCL17, CCL11, CCL7, IL8, IL5
32	Glucocorticoid Receptor Signaling36	8.0	CCL3, CCL17, CCL11, CCL7, IL8, IL5
33	TGF-Beta Pathway36	7.9	CCL3, CCL17, CCL11, CCL7, IL8, IL5
34	MAPK Family Pathway36	7.9	CCL3, CCL17, CCL11, CCL7, IL8, IL5
35	Tec Kinases Signaling36	7.7	CCL11, CCL17, CCR3, CCL3, CCL7, IL8
36	JAK-STAT Pathway36	7.4	IFNG, CCL3, CCL17, CCL11, CCL7, IL8
37	MIF Regulation of Innate Immune Cells36	7.2	CCL3, CCL17, CCL11, CCL7, IL8, IL5
38	MIF Mediated Glucocorticoid Regulation36	7.2	CSF2, CCL3, CCL17, CCL11, CCL7, IL8
39	PEDF Induced Signaling36	7.2	IL13, IL3, CSF2, CCL3, CCL17, CCL11
40	all-trans-Retinoic Acid Signaling in Brain36	7.2	CSF2, CCL3, CCL17, CCL11, CCL7, IL8
41	IL-6 Pathway36	7.2	CSF2, CCL3, CCL17, CCL11, CCL7, IL8
42	Endothelin-1 Signaling Pathway36	7.2	CSF2, CCL3, CCL17, CCL11, CCL7, IL8
43	PAK Pathway36	7.2	CSF2, CCL3, CCL17, CCL11, CCL7, IL8
44	Rho Family GTPases36	7.0	CSF2, PRG2, CCL3, CCL17, CCL11, CCL7
45	ERK Signaling36	7.0	CSF2, PRG2, CCL3, CCL17, CCL11, CCL7
46	STAT3 Pathway36	6.9	IL5, IL4, IL3, IL13, IL8, CCL7
47	Antioxidant Action of Vitamin-C36	6.9	CSF2, CCL3, CCR3, CCL17, CCL11, CCL7
48	p38 Signaling36	6.9	CCL17, CCR3, CCL3, CSF2, CCL11, CCL7
49	Molecular Mechanisms of Cancer36	6.7	CCL17, CCR3, CCL3, PRG2, CSF2, CCL11
50	Cytokine-cytokine receptor interaction20	6.4	IL13, CSF2, IFNG, CCL3, CCR3, CCL17

Compounds related to pulmonary eosinophilia according to GeneDecks:

(show top 50)    (show all 177)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	9.6	SFTPD, CCL11, CCL3
2	formoterol32 9 9	11.6	RNASE3, PDE4A, CSF2
3	sodium cromoglycate32	9.5	EPX, IGHE, RNASE3, CCL11, IL5
4	ketotifen32 9 9	11.5	IL5, RNASE3, IGHE, CCL11, PDE4A, EPX
5	lte432	9.4	IL5, EPX, RNASE3, CCL11, CYSLTR1, GGT1
6	praziquantel32 9 9	11.3	IL4, IL5, IGHE, RNASE3, GGT1, IL13
7	pge232	9.1	CYSLTR1, CCL11, CCL3, EPX, IL13, IL5
8	nedocromil sodium32	8.9	IL4, IL5, RNASE3, IGHE, IL3, IL8
9	budesonide32 42 9 9	11.8	CCL11, EPX, CSF2, RNASE3, IGHE, SFTPD
10	rolipram32 42	9.7	EPX, IFNG, CCL11, IL8, IL5, IL4
11	cetirizine32 9 18 9	11.7	RNASE3, IGHE, CCL11, IL8, IL5, CSF2
12	montelukast32 34 9 9	11.7	RNASE3, CYSLTR1, IGHE, CCL11, IL8, IL5
13	pgd232	8.6	EPX, PRG2, RNASE3, CYSLTR1, IGHE, CCR3
14	ltd432	8.6	RNASE3, CCR3, IL3, IL13, CYSLTR1, GGT1
15	salbutamol32 34 9 18 9	12.6	EPX, RNASE3, CYSLTR1, IGHE, CCL11, IL8
16	prednisolone32 9 9	10.5	EPX, CCL11, IL5, IL13, IGHE, CCL3
17	ionomycin32	8.4	IL3, IL5, CCL11, CCL3, CSF2
18	groalpha32	8.3	CSF2, IL13, CCL7, CCL11, CCL3, IL8
19	il-1232	8.3	IFNG, CSF2, IL5, IL13, IL8, IL4
20	ccl332	8.3	CCR3, CCL3, IFNG, CCL17, IL13, IL8
21	mip 1alpha32	8.3	CSF2, CCL3, IL13, IL3, IL4, IL8
22	salmeterol32 42 9 9	11.2	PDE4A, IL13, EPX, CSF2, RNASE3, CCL11
23	allergens32	8.0	PRG2, RNASE3, IFNG, IGHE, CCL17, CCL11
24	pentoxifylline32 9 9	10.0	IL8, IL4, IL13, PDE4A, IFNG, CSF2
25	methacholine32 9 9	9.9	PRG2, RNASE3, IGHE, CCL3, CCL11, IL8
26	anaphylatoxin32	7.9	IL3, IL4, IL8, CCL7, CCL3, RNASE3
27	heparin32 9 18 9	10.9	EPX, CSF2, PRG2, RNASE3, CCR3, CCL11
28	cysteine32	7.8	EPX, IFNG, CCL3, CCR3, SFTPD, SERPINA1
29	tacrolimus32 34 9 9	10.8	IL4, CCL3, IL5, GGT1, CCL11, CCL17
30	fluticasone propionate32 42 9 9	10.8	CSF2, RNASE3, IFNG, IGHE, CCL11, IL8
31	indomethacin32 9 9	9.8	IGHE, IFNG, CYSLTR1, PRG2, GGT1, CCL3
32	poly(i-c)32	7.7	CSF2, CCL11, CCL3, IFNG, IL8, IL5
33	gm-csf32	7.6	IL13, IL3, IL4, IL5, CSF2, IFNG
34	ltc432	7.5	GGT1, EPX, CSF2, PRG2, RNASE3, CYSLTR1
35	herbimycin a32 42	8.4	IL8, IL4, CSF2, IFNG, CCR3, CCL11
36	h2o232	7.4	EPX, CSF2, RNASE3, IL5, IL3, IL13
37	il 1032	7.3	CSF2, IFNG, CCL3, CCL17, IL8, IL5
38	hydrocortisone32 9 9	9.3	IGHE, IL5, IL4, IL3, IL8, CCL3
39	nitric oxide32 9 18 9	10.2	CCL3, IL8, IL13, SERPINA1, EPX, CCL17
40	fmlp32	7.1	EPX, CSF2, PRG2, RNASE3, CCL3, CCL11
41	butyrate32	6.9	CCL11, IL3, IL5, IL8, EPX, CSF2
42	leukotriene b432 42 18	8.8	CSF2, RNASE3, CYSLTR1, CCL3, CCL11, CCL7
43	tarc32	6.7	IL13, CSF2, IFNG, IGHE, CCL3, CCR3
44	thymidine32 18	7.6	IL13, SFTPD, SERPINA1, IL3, IL4, IL5
45	cycloheximide32	6.5	IL4, IL8, CCL7, CCL3, CSF2, IFNG
46	cyclosporin a32 42	7.3	CCL11, IL13, PDE4A, IL3, IL4, IL5
47	actinomycin d32	6.3	IL13, PDE4A, IL3, IL4, CCL7, CSF2
48	rantes32	6.2	IL13, IL3, CSF2, RNASE3, IFNG, CCL3
49	histamine32 18	6.0	IL3, IL4, IL5, IL8, CCL7, CCL11
50	dexamethasone32 42 34 9 9	8.6	PDE4A, CCL3, CCR3, CCL17, CCL11, CCL7

Cellular components related to pulmonary eosinophilia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	5.1	CCL17, CCL3, IFNG, RNASE3, RNASE2, PRG2
2	extracellular space	GO:005615	5.0	SFTPD, CSF2, IFNG, CCL3, CCR3, CCL17

Biological processes related to pulmonary eosinophilia according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	mast cell chemotaxis	GO:002551	10.2	CCL11, CCR3
2	regulation of proton transport	GO:010155	10.0	IL4, IL13
3	positive regulation of natural killer cell chemotaxis	GO:2000503	10.0	CCL3, CCL7
4	positive regulation of B cell proliferation	GO:030890	10.0	IL5, IL4, IL13
5	positive regulation of isotype switching to IgG isotypes	GO:048304	9.8	IL4, IFNG
6	eosinophil chemotaxis	GO:048245	9.7	CCL7, CCL11, CCR3, CCL3
7	positive regulation of chemokine biosynthetic process	GO:045080	9.7	IL4, IFNG
8	neutrophil chemotaxis	GO:030593	9.7	IL8, CCL3, IFNG
9	positive regulation of podosome assembly	GO:071803	9.7	IL5, CSF2
10	positive regulation of MHC class II biosynthetic process	GO:045348	9.6	IFNG, IL4
11	dendritic cell differentiation	GO:097028	9.4	CSF2, IL4
12	cellular calcium ion homeostasis	GO:006874	9.4	CCL7, CCL11, CCL3
13	positive regulation of interleukin-23 production	GO:032747	9.3	CSF2, IFNG
14	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.0	CSF2, IL4, IL3
15	cell-cell signaling	GO:007267	8.8	CCL3, CCL17, CCL7, IL3, IL13
16	chemotaxis	GO:006935	8.3	RNASE2, CYSLTR1, CCL3, CCR3, CCL17, CCL11
17	inflammatory response	GO:006954	8.1	CYSLTR1, CCL3, CCR3, CCL17, CCL11, CCL7
18	immune response	GO:006955	6.8	IL13, CSF2, PRG2, IGHE, CCL17, CCL11

Molecular functions related to pulmonary eosinophilia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR1 chemokine receptor binding	GO:031726	9.8	CCL7, CCL3
2	chemokine activity	GO:008009	9.0	IL8, CCL7, CCL11, CCL17, CCL3
3	growth factor activity	GO:008083	8.3	IL3, IL4, IL5, CSF2
4	cytokine activity	GO:005125	7.6	CSF2, IFNG, IL5, IL4, IL3, IL13