MCID: PLM035
MIFTS: 45

Pulmonary Eosinophilia malady

Respiratory diseases, Blood diseases categories
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Summaries for Pulmonary Eosinophilia

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33MalaCards
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MalaCards: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to eosinophilia and asthma. An important gene associated with Pulmonary Eosinophilia is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are IL4-mediated signaling events and Selected targets of GCR alpha. The compounds mometasone furoate and levocabastine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Eosinophilia

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Blood diseases


Aliases & Descriptions:

pulmonary eosinophilia 8 45
asthmatic pulmonary eosinophilia 62


External Ids:

Disease Ontology8 DOID:9498
MeSH35 D011657
ICD9CM27 518.3
ICD1025 J82

Related Diseases for Pulmonary Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia31.7IL5, CCL11, EPX, RNASE3
2asthma30.9IL5, RNASE3, EPX
3pneumonia30.2SFTPD, EPX, CCL11, IL5
4interstitial lung disease30.2CCL11, SFTPD
5chronic eosinophilic pneumonia30.2IL5, CCL11, RNASE3
6bronchitis30.2RNASE3, CCL11, IL5
7allergic asthma30.1IL5, CCL11, RNASE3, SFTPD, EPX
8aspergillosis30.1SFTPD
9folliculitis30.1CCL11
10allergic bronchopulmonary aspergillosis30.1IL5, SFTPD
11eosinophilic pneumonia30.0IL5, CCL11, RNASE3
12bronchiolitis29.9CCL11, RNASE3, IL5
13sarcoidosis29.9CCL11, SFTPD
14respiratory failure29.9RNASE3, EPX, SFTPD, CCL11
15filariasis10.4
16carrington syndrome10.2
17pulmonary function10.2
18loeffler syndrome10.2
19pneumothorax10.2
20tuberculosis10.2
21paragonimiasis10.1IL5
22conjunctivitis10.1RNASE3
23strongyloidiasis10.1IL5
24chronic rhinitis10.1RNASE3
25collagenous colitis10.1RNASE3
26schistosomiasis10.0RNASE3, IL5
27helminthiasis10.0RNASE3, IL5
28intrinsic asthma10.0RNASE3, IL5
29kimura disease10.0IL5, RNASE3
30churg-strauss syndrome10.0RNASE3, IL5
31angioedema10.0IL5, RNASE3
32proctitis10.0EPX, RNASE3
33eosinophilic gastroenteritis10.0IL5, CCL11
34eosinophilic esophagitis10.0IL5, CCL11
35myelitis10.0
36pulmonary tuberculosis10.0
37miliary tuberculosis10.0
38byssinosis10.0
39adult respiratory distress syndrome10.0
40sudden infant death syndrome10.0
41osteogenesis imperfecta10.0
42alpha 1-antitrypsin deficiency10.0
43b cell deficiency10.0
44hepatitis10.0
45lipodystrophy10.0
46pericarditis10.0
47pneumoconiosis10.0
48pulmonary fibrosis10.0
49vasculitis10.0
50cutaneous larva migrans10.0

Graphical network of the top 20 diseases related to Pulmonary Eosinophilia:



Diseases related to pulmonary eosinophilia

Symptoms for Pulmonary Eosinophilia

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Drugs & Therapeutics for Pulmonary Eosinophilia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Eosinophilia

Search NIH Clinical Center for Pulmonary Eosinophilia

Genetic Tests for Pulmonary Eosinophilia

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Anatomical Context for Pulmonary Eosinophilia

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Eosinophilia:

33
Lung, T cells, Bone, Testes, Bone marrow, Heart, Breast, B cells

Animal Models for Pulmonary Eosinophilia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Eosinophilia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7SFTPD, CCL11, IL5
2MP:00053978.0SFTPD, EPX, CCL11, IL5
3MP:00053877.8SFTPD, EPX, CCL11, IL5

Publications for Pulmonary Eosinophilia

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52PubMed
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Articles related to Pulmonary Eosinophilia:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice. (23926350)
2013
2
Acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia. (21808138)
2011
3
Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study. (21092270)
2010
4
Transient pulmonary eosinophilia incidentally found on low-dose computed tomography: findings in 40 individuals. (18303297)
2008
5
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma. (16730379)
2006
6
Elevated levels of fragmented laminin-5 gamma2-chain in bronchoalveolar lavage fluid from dogs with pulmonary eosinophilia. (16624727)
2006
7
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. (16374077)
2005
8
OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. (12794142)
2003
9
Pulmonary eosinophilia in mice devoid of interleukin-5. (12050181)
2002
10
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
11
Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia. (10529596)
1999
12
Pulmonary eosinophilia associated with montelukast. (10335014)
1999
13
Tropical pulmonary eosinophilia presenting as hydro-pneumothorax with broncho-pleural fistula. (10999107)
1999
14
Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. (9519215)
1998
15
5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. (9854052)
1998
16
Tropical pulmonary eosinophilia. Report of a case. (9515101)
1997
17
Recurrent post-partum pulmonary eosinophilia. (9516905)
1997
18
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
19
Characterization of the antigen-presenting cell and T cell requirements for induction of pulmonary eosinophilia in a murine model of asthma. (8938110)
1996
20
Syndrome resembling tropical pulmonary eosinophilia but of non-filarial aetiology: serological findings with filarial antigens. (8560543)
1995
21
Minocycline and pulmonary eosinophilia. (7787604)
1995
22
A case of tropical pulmonary eosinophilia. (7948545)
1994
23
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
24
Maloprim-induced pulmonary eosinophilia. (8417912)
1993
25
Tropical pulmonary eosinophilia in a 63-year-old woman from Guyana. (8324690)
1993
26
Pulmonary eosinophilia with systemic features: therapy and prognosis. (1470705)
1992
27
Pulmonary eosinophilia in pulmonary tuberculosis. (1600796)
1992
28
Correlation of lower respiratory tract inflammation with changes in lung function and chest roentgenograms in patients with untreated tropical pulmonary eosinophilia. (1876879)
1991
29
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
30
Rash and pulmonary eosinophilia associated with fenbufen. (2137356)
1990
31
Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex. (1698322)
1990
32
Corticosteroid treatment and prognosis in pulmonary eosinophilia. (2595633)
1989
33
Airway hyperreactivity in tropical pulmonary eosinophilia. (3359833)
1988
34
Pulmonary eosinophilia associated with cutaneous larva migrans. (3969661)
1985
35
Hepatic involvement in tropical pulmonary eosinophilia. (6501178)
1984
36
Tropical pulmonary eosinophilia: an unusual presentation. (6618529)
1983
37
Epidemiology of bancroftian filariasis in East Godavari district (Andhra Pradesh)--incidence of tropical pulmonary eosinophilia. (7040222)
1981
38
Lipodystrophy and pulmonary eosinophilia. (7228604)
1981
39
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
40
Immunoglobulins in byssinosis, chronic bronchitis and pulmonary eosinophilia. (730695)
1978
41
Pulmonary eosinophilia. Netaji oration. Part II. (730723)
1978
42
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
43
Cytophilic antibodies in bronchopulmonary aspergilloma and cryptogenic pulmonary eosinophilia. (63346)
1976
44
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
45
Leukocyte adhesion phenomenon in pulmonary eosinophilia (tropical eosinophilia). (4683591)
1973
46
PRELIMINARY STUDIES ON THE PRODUCTION OF EXPERIMENTAL PULMONARY EOSINOPHILIA BY TISSUE ANTIGEN ANTIBODY REACTION OF THE HOST. (14235491)
1964
47
Pulmonary eosinophilia; report of a case. (13413195)
1957
48
Prolonged pulmonary eosinophilia; a report on three cases. (14363706)
1955
49
Myelitis following arsenic therapy in pulmonary eosinophilia. (13017551)
1952
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Variations for Pulmonary Eosinophilia

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Expression for genes affiliated with Pulmonary Eosinophilia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Eosinophilia

Search GEO for disease gene expression data for Pulmonary Eosinophilia.

Pathways for genes affiliated with Pulmonary Eosinophilia

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Sources:
50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 60Thomson Reuters, 30KEGG, 53QIAGEN
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Pathways related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2IL5, CCL11
29.2IL5, CCL11
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1CCL11, SFTPD
4
Show member pathways
8.1RNASE3, IL5, CCL11, EPX

Compounds for genes affiliated with Pulmonary Eosinophilia

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1mometasone furoate45 6110.8RNASE3, IL5
2levocabastine45 29 1111.8IL5, RNASE3
3beclomethasone dipropionate459.8IL5, RNASE3
4toluene diisocyanate459.8RNASE3, IL5
5nedocromil sodium459.8RNASE3, IL5
6praziquantel45 1110.7RNASE3, IL5
7tele-methylhistamine459.7EPX, RNASE3
8azelastine45 1110.6IL5, RNASE3
9ltd4459.6IL5, RNASE3
10sephadex459.6EPX, RNASE3
115-oxoete459.5IL5, CCL11
12anti-histamine459.4CCL11, RNASE3
13roxithromycin45 29 1111.4CCL11, IL5
14anti-fungal459.4IL5, RNASE3, SFTPD
15theophylline45 29 24 1112.2RNASE3, EPX, IL5
16p005459.2EPX, RNASE3, SFTPD
17clarithromycin45 1110.2CCL11, IL5
18percoll459.2RNASE3, IL5
19unicap459.1IL5, CCL11, RNASE3
20pranlukast45 29 1111.1RNASE3, CCL11, IL5
21montelukast45 51 29 1112.1RNASE3, CCL11, IL5
22fluticasone propionate45 51 61 1112.1IL5, CCL11, RNASE3
23methacholine45 51 1111.1IL5, CCL11, RNASE3
24n-formylmethionyl-leucylphenylalanine459.1RNASE3, CCL11, IL5
25rolipram45 61 2911.0EPX, CCL11, IL5
26endotoxin458.9SFTPD, RNASE3, CCL11
27rantes458.9IL5, CCL11, RNASE3
28dithiothreitol458.9CCL11, EPX, RNASE3
29butyrate458.7IL5, CCL11, EPX
30cyclosporin a45 29 6110.7IL5, CCL11, RNASE3
31sodium cromoglycate458.5RNASE3, EPX, CCL11, IL5
32lte4458.5RNASE3, EPX, CCL11, IL5
33cetirizine45 29 24 1111.5RNASE3, EPX, CCL11, IL5
34salmeterol45 51 29 1111.5RNASE3, EPX, CCL11, IL5
35ketotifen45 119.5RNASE3, EPX, CCL11, IL5
36ltc4458.5RNASE3, EPX, CCL11, IL5
37salbutamol45 51 29 24 1112.5RNASE3, EPX, CCL11, IL5
38pgd2458.5IL5, CCL11, EPX, RNASE3
39leukotriene b445 61 2410.5RNASE3, EPX, CCL11, IL5
40fmlp458.5IL5, CCL11, EPX, RNASE3
41pge2458.4IL5, CCL11, EPX, RNASE3
42heparin45 29 24 1111.4RNASE3, EPX, CCL11, IL5
43steroid458.3SFTPD, RNASE3, EPX, CCL11
44nitric oxide45 24 1110.3CCL11, EPX, RNASE3, SFTPD
45budesonide45 51 1110.0IL5, CCL11, EPX, RNASE3, SFTPD
46allergens458.0SFTPD, RNASE3, EPX, CCL11, IL5
47prednisolone45 29 1110.0SFTPD, RNASE3, EPX, CCL11, IL5
48histamine45 29 2410.0SFTPD, RNASE3, EPX, CCL11, IL5
49dexamethasone45 51 29 1110.9SFTPD, RNASE3, EPX, CCL11, IL5
50lipid457.9CCL11, EPX, RNASE3, SFTPD

GO Terms for genes affiliated with Pulmonary Eosinophilia

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16Gene Ontology
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Cellular components related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7IL5, CCL11, SFTPD
2extracellular regionGO:0055767.9IL5, CCL11, RNASE3, SFTPD

Biological processes related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.4RNASE3, SFTPD

Products for genes affiliated with Pulmonary Eosinophilia

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Sources for Pulmonary Eosinophilia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet