MCID: PLM035
MIFTS: 43

Pulmonary Eosinophilia malady

Respiratory category

Summaries for Pulmonary Eosinophilia

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33MalaCards
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MalaCards: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to asthma and allergic asthma. An important gene associated with Pulmonary Eosinophilia is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are OX40 Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and hydrocortisone have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Eosinophilia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

pulmonary eosinophilia 8 45
asthmatic pulmonary eosinophilia 61


External Ids:

Disease Ontology8 DOID:9498
MeSH35 D011657
ICD9CM27 518.3
ICD1025 J82

Related Diseases for Pulmonary Eosinophilia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.0IL13, CCL11
2allergic asthma30.3IL8, IL4, IL5, IL3, IL13, RNASE3
3chronic eosinophilic pneumonia30.2IL5, RNASE3, CCL11
4tuberculosis30.2SERPINA1, IL4, EPX, SFTPD, CCL7, CCL3
5bronchitis30.2SERPINA1, IL8, IL5, RNASE3, IGHE, CCR3
6folliculitis30.0CCL11
7aspergillosis30.0SFTPD, CCL3
8allergic bronchopulmonary aspergillosis29.9IL4, IL5, IGHE, SFTPD
9vasculitis29.9SERPINA1, CYSLTR1, PRG2
10bronchiolitis29.9IL8, IL5, IL13, RNASE3, IGHE, CCL3
11pulmonary function10.4
12pulmonary tuberculosis10.1
13loeffler syndrome10.1
14carrington syndrome10.1
15myelitis10.0
16pulmonary aspergilloma10.0
17adult respiratory distress syndrome10.0
18pulmonary sarcoidosis10.0
19sudden infant death syndrome10.0
20miliary tuberculosis10.0
21byssinosis10.0
22adult syndrome10.0
23osteogenesis imperfecta10.0
24n syndrome10.0
25cutaneous larva migrans10.0
26eosinophilic pustular folliculitis10.0
27periarteritis nodosa10.0
28spontaneous pneumothorax10.0
29asthma 110.0
30endocarditis10.0EPX
31pleurisy10.0PDE4A
32ischemia10.0EPX
33acquired immunodeficiency syndrome10.0CCR3
34dermatitis herpetiformis10.0CCL11
35malignant glioma10.0IL13
36coronary heart disease10.0GGT1
37toxic shock syndrome10.0CCL3
38periodontitis10.0IL8
39dementia10.0CCR3
40multiple myeloma10.0CCL3
41meningitis10.0IL8
42bronchiolitis obliterans10.0IL8
43migraine10.0RNASE2
44hypertension10.0GGT1
45common variable immune deficiency10.0IL4
46cholangitis10.0GGT1
47chronic rhinitis10.0RNASE3
48influenza10.0SFTPD, CCL11
49corneal ulcer10.0PRG2, CCL11
50uveitis10.0IL4, CCL11

Graphical network of the top 20 diseases related to Pulmonary Eosinophilia:



Diseases related to pulmonary eosinophilia

Clinical Features for Pulmonary Eosinophilia

Drugs & Therapeutics for Pulmonary Eosinophilia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Pulmonary Eosinophilia

Search NIH Clinical Center for Pulmonary Eosinophilia

Search CenterWatch for Pulmonary Eosinophilia

Genetic Tests for Pulmonary Eosinophilia

Anatomical Context for Pulmonary Eosinophilia

Animal Models for Pulmonary Eosinophilia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Eosinophilia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5CYSLTR1, PRG2, SFTPD, CCL11
2MP:00053976.2PRG2, SFTPD, CCL7, CCR3, CCL3, CCL11
3MP:00053875.5GGT1, CCL11, CCL17, CCL3, CCR3, CCL7

Publications for Pulmonary Eosinophilia

Sources:
51PubMed
See all sources

Articles related to Pulmonary Eosinophilia:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Pulmonary infiltrates and eosinophilia in a 25-year-old traveler. (23785527)
2013
2
Tropical pulmonary eosinophilia misdiagnosed as miliary tuberculosis: a case report and literature review. (22172479)
2012
3
Pulmonary infiltrates with eosinophilia syndrome in ibuprofen overdose. (22932657)
2012
4
FICZ, a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma. (22561122)
2012
5
Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine. (20007928)
2010
6
Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia. (20719375)
2010
7
Daptomycin-induced eosinophilia without pulmonary involvement. (21116001)
2010
8
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. (18094193)
2008
9
Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. (17597386)
2008
10
A critical role for Pin1 in allergic pulmonary eosinophilia in rats. (17720236)
2007
11
C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. (17079327)
2007
12
Pulmonary eosinophilia in mice devoid of interleukin-5. (12050181)
2002
13
Clinical findings, bronchoalveolar lavage fluid cytology and matrix metalloproteinase-2 and -9 in canine pulmonary eosinophilia. (12093192)
2002
14
Tropical pulmonary eosinophilia and filariasis in Pakistan. (11485099)
2001
15
Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. (10030835)
1999
16
Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. (9519215)
1998
17
5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. (9854052)
1998
18
Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. (9802959)
1998
19
Dapsone induced pulmonary eosinophilia without cutaneous allergic manifestations--an unusual encounter--a case report. (9693685)
1998
20
Pulmonary eosinophilia associated with aminoglutethimide. (9847965)
1998
21
Pulmonary eosinophilia and inflammation in allergic mice. (9517892)
1998
22
Tropical pulmonary eosinophilia: a comparative evaluation of plain chest radiography and computed tomography. (8838885)
1996
23
Pulmonary eosinophilia due to Trichomonas tenax. (8711692)
1996
24
Minocycline and pulmonary eosinophilia. (7787604)
1995
25
Increased expression of intercellular adhesion molecule-1 (ICAM-1) in a murine model of pulmonary eosinophilia and high IgE level. (7743671)
1995
26
Chronic pulmonary disorders, including tropical pulmonary eosinophilia, in villages with endemic lymphatic filariasis in Tanga region and in Tanga town, Tanzania. (7570881)
1995
27
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
28
Epidemiology of pulmonary eosinophilia in rural south India--a prospective study, 1981-86. (8120502)
1993
29
Ventilation-perfusion scintiscanning in tropical pulmonary eosinophilia. (8339640)
1993
30
An eosinophilic granuloma containing an adult female Wuchereria bancrofti in a patient with tropical pulmonary eosinophilia. (1475828)
1992
31
Mebendazole with levamisole in tropical pulmonary eosinophilia: an alternative in diethylcarbamazine allergy. (1641900)
1992
32
Pulmonary involvement in the eosinophilia-myalgia syndrome. (1989790)
1991
33
Tropical pulmonary eosinophilia in Boston. (3186345)
1988
34
Tropical pulmonary eosinophilia presenting as pneumonic consolidation. (3428943)
1987
35
Pulmonary eosinophilia associated with naproxen therapy. (3560143)
1987
36
Pulmonary eosinophilia associated with cutaneous larva migrans. (3969661)
1985
37
Tropical pulmonary eosinophilia--a clinico-physiological study in rural central India. (6545252)
1984
38
Tropical pulmonary eosinophilia. A clinical study. (6571581)
1983
39
Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine. (7100019)
1982
40
Epidemiology of bancroftian filariasis in East Godavari district (Andhra Pradesh)--incidence of tropical pulmonary eosinophilia. (7040222)
1981
41
Tropical pulmonary eosinophilia in a Saudi Arabian female. (7339607)
1981
42
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
43
Tropical pulmonary eosinophilia and coal worker's pneumoconiosis among Dhanbad coal miners (new observations). (1176164)
1975
44
Pulmonary eosinophilia (a clinico-pathological study of 60 cases). (4448815)
1974
45
Pulmonary infiltration associated with blood eosinophilia (P.I.E.): a clinical study of Loeffler's syndrome and of periarteritis nodosa with P.I.E. syndrome. (13816968)
1960
46
Tropical pulmonary eosinophilia. (13612472)
1958
47
Tropical pulmonary eosinophilia in relation to filarial infections (Wuchereria spp.) of animals; preliminary note. (13581131)
1958
48
Clinical observations related to pulmonary eosinophilia. (13235631)
1955
49
Myelitis following arsenic therapy in pulmonary eosinophilia. (13017551)
1952
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Genetic Variations for Pulmonary Eosinophilia

Expression for genes affiliated with Pulmonary Eosinophilia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Eosinophilia

Search GEO for disease gene expression data for Pulmonary Eosinophilia.

Pathways for genes affiliated with Pulmonary Eosinophilia

Sources:
52QIAGEN, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 54Reactome
See all sources

Pathways related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL13, IL5, IL4
29.9IL13, IL5, IL4
39.8IL8, IL4, CCL11
4
Hide members
9.8GGT1, CYSLTR1
59.8IL4, IL5, IL3
69.6IL8, IL4, IL5, CCL11
79.6IL8, IL4, IL5, IL13
8
Immune response CCR3 signaling in eosinophils
Hide members
9.6IL8, CCL7, CCR3, CCL11
99.5IL13, IL3, IL5, IL4
10
Hide members
9.5IL8, IL4, IL5, IL3
119.3IL13, IL3, IL5, IL4, IL8
129.2CCL3, SFTPD, PRG2, SERPINA1
139.1CCL11, CCL17, IGHE, IL5, IL4
148.9CCL11, CCL17, CCL3, CCR3, CCL7, IL8
15
Hide members
8.9CCL11, CCL17, CCL3, CCR3, CCL7, IL8
16
Hide members
8.8CCL11, IGHE, IL13, IL3, IL5, IL4
17
Hide members
8.8CCL17, CCL3, CCR3, CCL7, PRG2, IL5
18
Hide members
8.6CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
19
Hide members
8.6IL4, CCL11, PRG2, EPX, RNASE3, IL13
20
Hide members
8.5CCL11, CCL17, CCL3, CCR3, CCL7, PRG2
21
Hide members
8.4CCL11, CCL17, CCL3, CCR3, CCL7, IL13
22
Hide members
8.2CCL11, CCL17, CCL3, CCR3, CCL7, PDE4A
23
Hide members
8.1CCL11, CCL17, CCL3, CCL7, IL13, IL3
24
Hide members
7.9CCL11, IL8, IL4, IL5, IL3, IL13
25
Hide members
7.9IL4, IL5, IL3, IL13, CCL7, CCR3

Compounds for genes affiliated with Pulmonary Eosinophilia

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1rolipram45 60 2912.3EPX, PDE4A
2hydrocortisone45 2 60 1112.9IL8, IGHE
3indomethacin45 60 29 1112.9IL5, GGT1, PRG2
4pge2459.8PDE4A, CCL11, CYSLTR1, EPX
5pranlukast45 29 1111.7CCL11, CYSLTR1, RNASE3, IL5, IL4
6formoterol45 29 1111.6IL13, RNASE3, PDE4A, IL4, IL8
7sodium cromoglycate459.5IGHE, EPX, IL5, RNASE3, CCL11
8mcp 1459.5CCR3, CCL7, IL5, IL8, CCL3
9lte4459.4CCL11, GGT1, IL5, CYSLTR1, RNASE3, EPX
10cetirizine45 29 11 2412.4IGHE, CCL11, IL8, IL5, RNASE3, EPX
11omalizumab45 1110.3IL5, IGHE, IL13, IL4
12mip 1alpha459.3IL3, IL8, IL4, IL13, CCL3
13rantes459.3IL3, IL4, RNASE3, CCL7, CCL3, CCL11
14azelastine45 1110.2RNASE3, IL3, IL5, IL4, IGHE
15nedocromil sodium459.2IL4, IL8, IL5, IL3, RNASE3, IGHE
16ketotifen45 1110.2IL5, RNASE3, EPX, IGHE, CCL11, PDE4A
17h2o2459.2IL13, EPX, IL3, CCL3, PDE4A
18anaphylatoxin459.2CCL7, IL3, IL4, CCL3, IL8, RNASE3
19poly(i-c)459.2IL4, IL8, IL3, CCL3, CCL11, IL5
20unicap459.1IGHE, RNASE3, IL5, CCL11
21fluticasone propionate45 50 60 1112.1IL4, IL13, RNASE3, IL8, CCL11, IGHE
22salmeterol45 50 29 1112.1IL4, IL8, IL5, IL13, RNASE3, CCL11
23ltd4459.1GGT1, IL5, CCR3, CYSLTR1, RNASE3, IL13
24praziquantel45 1110.1IL5, IL4, GGT1, IL13, RNASE3, IGHE
25ccl445 2910.0CCL11, IL13, CCL7, CCR3, CCL3, CCL17
26ccl345 2910.0CCL11, CCL17, CCL3, CCR3, CCL7, IL13
27il 10459.0CCL3, IL4, IL3, IL5, CCL17, IL8
28montelukast45 50 29 1111.9CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
29prednisolone45 29 1110.7IGHE, SFTPD, CCL11, CCL3, EPX, RNASE3
30pgd2458.6IL5, IL13, CCL11, CCR3, PRG2, IGHE
31heparin45 29 11 2411.6RNASE3, PRG2, CCR3, CCL3, CCL11, EPX
32ltc4458.6PRG2, EPX, CYSLTR1, RNASE3, IL13, IL3
33salbutamol45 50 29 11 2412.5CCL11, PDE4A, IGHE, EPX, CYSLTR1, RNASE3
34tacrolimus45 50 1110.5CCL11, CCL17, CCL3, IL4, GGT1, IL5
35methacholine45 119.4IL8, CCL11, CCL3, PRG2, IGHE, RNASE3
36allergens458.4PRG2, IGHE, EPX, RNASE3, IL13, IL5
37budesonide45 50 1110.4CCL11, SFTPD, PDE4A, IGHE, EPX, RNASE3
38tarc458.2CCL11, CCL17, CCL3, CCR3, CCL7, IGHE
39thymidine45 249.1SERPINA1, CCL3, CCR3, SFTPD, CCL11, IL13
40leukotriene b445 60 2410.1CCL3, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
41fmlp458.0CCL11, CCL3, CCL7, PDE4A, PRG2, EPX
42polysaccharide457.9SERPINA1, GGT1, IL3, IGHE, CCL3, SFTPD
43lactate457.8SFTPD, IL8, IGHE, IL3, IL13, RNASE3
44nitric oxide45 11 249.8SFTPD, EPX, PRG2, RNASE3, PDE4A, IL13
45cyclosporin a45 29 609.7IL5, CCL11, CCL17, RNASE3, IGHE, PDE4A
46actinomycin d457.5CCL11, CCL3, CCR3, CCL7, PDE4A, PRG2
47cysteine457.5CCL3, CCR3, SFTPD, PRG2, EPX, IL3
48tyrosine457.3RNASE3, SERPINA1, IL4, PDE4A, IL5, CYSLTR1
49histamine45 29 248.6CCR3, CCL7, SFTPD, PDE4A, PRG2, IGHE
50dexamethasone45 50 29 119.2CCL7, SFTPD, PDE4A, EPX, CYSLTR1, RNASE3

GO Terms for genes affiliated with Pulmonary Eosinophilia

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CCL17, CCL3, CCR3, CCL7, SFTPD, IL13
2extracellular regionGO:0055765.9SERPINA1, CCL11, CCL17, CCL3, CCL7, SFTPD

Biological processes related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCL11, CCR3
2regulation of proton transportGO:01015510.1IL13, IL4
3positive regulation of B cell proliferationGO:03089010.0IL4, IL5, IL13
4positive regulation of natural killer cell chemotaxisGO:20005039.9CCL3, CCL7
5positive regulation of angiogenesisGO:0457669.7CCL11, CCR3, CYSLTR1
6eosinophil chemotaxisGO:0482459.6CCL11, CCL3, CCR3, CCL7
7cellular calcium ion homeostasisGO:0068749.6CCL7, CCL3, CCL11
8cytoskeleton organizationGO:0070109.6CCL7, CCL3, CCL11
9macrophage chemotaxisGO:0482469.6SFTPD, CCL3
10cell-cell signalingGO:0072679.2CCL17, CCL3, CCL7, IL13, IL3
11inflammatory responseGO:0069548.5CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
12chemotaxisGO:0069358.3CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
13immune responseGO:0069558.0IL8, CCL11, CCL17, CCL7, PRG2, IGHE

Molecular functions related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.7CCL7, CCL3
2pancreatic ribonuclease activityGO:0045229.7RNASE2, RNASE3
3cytokine activityGO:0051259.5IL13, IL3, IL5, IL4
4ribonuclease activityGO:0045409.4RNASE2, RNASE3
5chemokine activityGO:0080099.2IL8, CCL7, CCL3, CCL17, CCL11

Products for genes affiliated with Pulmonary Eosinophilia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Eosinophilia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet