MCID: PLM035
MIFTS: 51

Pulmonary Eosinophilia malady

Respiratory diseases category

Summaries for Pulmonary Eosinophilia

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MalaCards: Pulmonary Eosinophilia, also known as asthmatic pulmonary eosinophilia, is related to eosinophilia and asthma. An important gene associated with Pulmonary Eosinophilia is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are OX40 Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone marrow, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Classifications for Pulmonary Eosinophilia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary eosinophilia 8 44
asthmatic pulmonary eosinophilia 60


External Ids:

Disease Ontology8 DOID:9498
MeSH34 D011657
ICD9CM27 518.3
ICD1025 J82

Related Diseases for Pulmonary Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia31.7IL8, IL4, IL5, IL3, IL13, RNASE2
2asthma30.8IL13, CCL11
3filariasis30.5IL5, IL13, IGHE
4allergic asthma30.3IL8, IL4, IL5, IL3, IL13, RNASE3
5pneumonia30.2SERPINA1, IL8, IL5, IL13, EPX, PDE4A
6chronic eosinophilic pneumonia30.1IL5, RNASE3, CCL11
7interstitial lung disease30.1IL8, SFTPD, CCL3, CCL17, CCL11
8tuberculosis30.1SERPINA1, IL4, EPX, SFTPD, CCL7, CCL3
9bronchitis30.1SERPINA1, IL8, IL5, RNASE3, IGHE, CCR3
10folliculitis29.9CCL11
11aspergillosis29.9SFTPD, CCL3
12alpha 1-antitrypsin deficiency29.9SERPINA1
13respiratory failure29.9SERPINA1, SFTPD
14sarcoidosis29.9IL13, SFTPD, CCL3, CCL11
15allergic bronchopulmonary aspergillosis29.9IL4, IL5, IGHE, SFTPD
16hepatitis29.9SERPINA1, GGT1, CCL11
17vasculitis29.9SERPINA1, CYSLTR1, PRG2
18bronchiolitis29.9IL8, IL5, IL13, RNASE3, IGHE, CCL3
19pulmonary fibrosis29.9IL8, IL13, CYSLTR1, PRG2, SFTPD, CCL3
20eosinophilic pneumonia29.9IL5, IL3, IL13, RNASE3, IGHE, CCL17
21carrington syndrome10.2
22pulmonary tuberculosis10.1
23loeffler syndrome10.1
24pneumothorax10.1
25endocarditis10.0EPX
26pleurisy10.0PDE4A
27ischemia10.0EPX
28acquired immunodeficiency syndrome10.0CCR3
29dermatitis herpetiformis10.0CCL11
30malignant glioma10.0IL13
31coronary heart disease10.0GGT1
32toxic shock syndrome10.0CCL3
33periodontitis10.0IL8
34dementia10.0CCR3
35multiple myeloma10.0CCL3
36meningitis10.0IL8
37bronchiolitis obliterans10.0IL8
38migraine10.0RNASE2
39hypertension10.0GGT1
40common variable immune deficiency10.0IL4
41cholangitis10.0GGT1
42chronic rhinitis10.0RNASE3
43influenza10.0SFTPD, CCL11
44corneal ulcer10.0PRG2, CCL11
45uveitis10.0IL4, CCL11
46myocardial infarction10.0CCL3, CCL11
47proctitis10.0RNASE3, EPX
48conjunctivitis10.0RNASE3, IGHE
49synovitis10.0IL8
50proteinuria10.0GGT1

Graphical network of the top 20 diseases related to Pulmonary Eosinophilia:



Diseases related to pulmonary eosinophilia

Clinical Features for Pulmonary Eosinophilia

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Drugs & Therapeutics for Pulmonary Eosinophilia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Pulmonary Eosinophilia

Search NIH Clinical Center for Pulmonary Eosinophilia

Search CenterWatch for Pulmonary Eosinophilia

Genetic Tests for Pulmonary Eosinophilia

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Anatomical Context for Pulmonary Eosinophilia

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Eosinophilia:

32
Lung, T cells, Bone marrow, Bone, Heart, Breast, Testes, B cells

Animal Models for Pulmonary Eosinophilia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Eosinophilia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5CYSLTR1, PRG2, SFTPD, CCL11
2MP:00053976.2PRG2, SFTPD, CCL7, CCR3, CCL3, CCL11
3MP:00053875.5GGT1, CCL11, CCL17, CCL3, CCR3, CCL7

Publications for Pulmonary Eosinophilia

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50PubMed
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Articles related to Pulmonary Eosinophilia:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
A cavitating pulmonary lesion with eosinophilia. (22821685)
2013
2
Systemic vasculitis in a patient with atopic dermatitis, eosinophilia, pulmonary-renal syndrome, and positive myeloperoxidase antibody: a classification conundrum. (22157272)
2012
3
A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent. (21160052)
2011
4
Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study. (21092270)
2010
5
Piperacillin-associated pulmonary infiltrates with eosinophilia: a case report. (20422064)
2010
6
Serum C3d levels in tropical pulmonary eosinophilia. (20424307)
2010
7
Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid. (20637839)
2010
8
Tropical pulmonary eosinophilia: pathogenesis, diagnosis and management. (17940489)
2007
9
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma. (16730379)
2006
10
Parasitic pulmonary eosinophilia. (16612768)
2006
11
The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. (16210640)
2005
12
Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. (12696122)
2003
13
A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. (12750406)
2003
14
Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia. (12595450)
2003
15
Late appearance of t(1;19)(q11;q11) in myelodysplastic syndrome associated with dysplastic eosinophilia and pulmonary alveolar proteinosis. (12547151)
2002
16
Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of mice. (11983224)
2002
17
Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection. (11981825)
2002
18
Suppressive effects of F-1322 on the antigen-induced late asthmatic response and pulmonary eosinophilia in guinea pigs. (11698072)
2001
19
Ovalbumin aerosols induce airway hyperreactivity in naA^ve DO11.10 T cell receptor transgenic mice without pulmonary eosinophilia or OVA-specific antibody. (11310839)
2001
20
Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. (10807686)
2000
21
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
22
Tropical pulmonary eosinophilia presenting as hydro-pneumothorax with broncho-pleural fistula. (10999107)
1999
23
Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to the attachment G protein. (9725246)
1998
24
Tropical pulmonary eosinophilia. (9631810)
1998
25
Pulmonary eosinophilia. (8872069)
1996
26
Tropical pulmonary eosinophilia. (8987291)
1996
27
Pulmonary eosinophilia in sudden infant death syndrome. (8568597)
1995
28
Correlation of lower respiratory tract inflammation with changes in lung function and chest roentgenograms in patients with untreated tropical pulmonary eosinophilia. (1876879)
1991
29
Eosinophilia-myalgia syndrome associated with L-tryptophan. A case report with pulmonary manifestations and review of the literature. (1656679)
1991
30
Theophylline reduces pulmonary eosinophilia after various types of active anaphylactic shock in guinea-pigs. (1687591)
1991
31
Atypical radiological presentation of tropical pulmonary eosinophilia. (1791032)
1991
32
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
33
Rash and pulmonary eosinophilia associated with fenbufen. (2137356)
1990
34
Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132. (2210871)
1990
35
Pulmonary eosinophilia. (2315879)
1990
36
Airway hyperreactivity in tropical pulmonary eosinophilia. (3359833)
1988
37
A case history: Pulmonary eosinophilia and coccidiodal infections. (3677833)
1987
38
Pulmonary eosinophilia presenting with bilateral pleural effusion and consolidation. (6530259)
1984
39
Microfilarial granuloma of the breast in a patient with tropical pulmonary eosinophilia. (869111)
1977
40
Cytophilic antibodies in bronchopulmonary aspergilloma and cryptogenic pulmonary eosinophilia. (63346)
1976
41
Pulmonary eosinophilia after substitution of aerosol for oral corticosteroid therapy. (1103929)
1975
42
Asthma, pulmonary eosinophilia, and allergic alveolitis. (4633728)
1973
43
Bronchitis as a sequel of tropical pulmonary eosinophilia. (5520224)
1970
44
Correlation of diethylcarbamazine (Hetrazan) in blood to therapeutic response in cases of tropical pulmonary eosinophilia. (5655075)
1968
45
PRELIMINARY STUDIES ON THE PRODUCTION OF EXPERIMENTAL PULMONARY EOSINOPHILIA BY TISSUE ANTIGEN ANTIBODY REACTION OF THE HOST. (14235491)
1964
46
Occult filariasis: its relatioship with tropical pulmonary eosinophilia. (13957795)
1962
47
Pulmonary infiltration with eosinophilia. Report of two cases of farmer's lung. (13718470)
1961
48
Metaplastic cells in sputum of patients with pulmonary eosinophilia. (13647655)
1959
49
Diethylcarbamazine (oral and parenteral therapy) in tropical pulmonary eosinophilia. (13654773)
1959
50
Tropical pulmonary eosinophilia. (13374360)
1956

Genetic Variations for Pulmonary Eosinophilia

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Expression for genes affiliated with Pulmonary Eosinophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Eosinophilia

Search GEO for disease gene expression data for Pulmonary Eosinophilia.

Pathways for genes affiliated with Pulmonary Eosinophilia

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Sources:
51QIAGEN, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 53Reactome
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Pathways related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL13, IL5, IL4
29.9IL13, IL5, IL4
39.8IL8, IL4, CCL11
4
Hide members
9.8GGT1, CYSLTR1
59.8IL4, IL5, IL3
69.6IL8, IL4, IL5, CCL11
79.6IL8, IL4, IL5, IL13
8
Immune response CCR3 signaling in eosinophils
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9.6IL8, CCL7, CCR3, CCL11
99.5IL13, IL3, IL5, IL4
10
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9.5IL8, IL4, IL5, IL3
119.3IL13, IL3, IL5, IL4, IL8
129.2CCL3, SFTPD, PRG2, SERPINA1
139.1CCL11, CCL17, IGHE, IL5, IL4
148.9CCL11, CCL17, CCL3, CCR3, CCL7, IL8
15
Hide members
8.9CCL11, CCL17, CCL3, CCR3, CCL7, IL8
16
Hide members
8.8CCL11, IGHE, IL13, IL3, IL5, IL4
17
Hide members
8.8CCL17, CCL3, CCR3, CCL7, PRG2, IL5
18
Hide members
8.6CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
19
Hide members
8.6IL4, CCL11, PRG2, EPX, RNASE3, IL13
20
Hide members
8.5CCL11, CCL17, CCL3, CCR3, CCL7, PRG2
21
Hide members
8.4CCL11, CCL17, CCL3, CCR3, CCL7, IL13
22
Hide members
8.2CCL11, CCL17, CCL3, CCR3, CCL7, PDE4A
23
Hide members
8.1CCL11, CCL17, CCL3, CCL7, IL13, IL3
24
Hide members
7.9CCL11, IL8, IL4, IL5, IL3, IL13
25
Hide members
7.9IL4, IL5, IL3, IL13, CCL7, CCR3

Compounds for genes affiliated with Pulmonary Eosinophilia

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 166)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.3EPX, PDE4A
2hydrocortisone44 2 59 1112.9IL8, IGHE
3indomethacin44 59 28 1112.9IL5, GGT1, PRG2
4pge2449.8PDE4A, CCL11, CYSLTR1, EPX
5pranlukast44 28 1111.7CCL11, CYSLTR1, RNASE3, IL5, IL4
6formoterol44 28 1111.6IL13, RNASE3, PDE4A, IL4, IL8
7sodium cromoglycate449.5IGHE, EPX, IL5, RNASE3, CCL11
8mcp 1449.5CCR3, CCL7, IL5, IL8, CCL3
9lte4449.4CCL11, GGT1, IL5, CYSLTR1, RNASE3, EPX
10cetirizine44 28 11 2412.4IGHE, CCL11, IL8, IL5, RNASE3, EPX
11omalizumab44 1110.3IL5, IGHE, IL13, IL4
12mip 1alpha449.3IL3, IL8, IL4, IL13, CCL3
13rantes449.3IL3, IL4, RNASE3, CCL7, CCL3, CCL11
14azelastine44 1110.2RNASE3, IL3, IL5, IL4, IGHE
15nedocromil sodium449.2IL4, IL8, IL5, IL3, RNASE3, IGHE
16ketotifen44 1110.2IL5, RNASE3, EPX, IGHE, CCL11, PDE4A
17h2o2449.2IL13, EPX, IL3, CCL3, PDE4A
18anaphylatoxin449.2CCL7, IL3, IL4, CCL3, IL8, RNASE3
19poly(i-c)449.2IL4, IL8, IL3, CCL3, CCL11, IL5
20unicap449.1IGHE, RNASE3, IL5, CCL11
21fluticasone propionate44 49 59 1112.1IL4, IL13, RNASE3, IL8, CCL11, IGHE
22salmeterol44 49 28 1112.1IL4, IL8, IL5, IL13, RNASE3, CCL11
23ltd4449.1GGT1, IL5, CCR3, CYSLTR1, RNASE3, IL13
24praziquantel44 1110.1IL5, IL4, GGT1, IL13, RNASE3, IGHE
25ccl444 2810.0CCL11, IL13, CCL7, CCR3, CCL3, CCL17
26ccl344 2810.0CCL11, CCL17, CCL3, CCR3, CCL7, IL13
27il 10449.0CCL3, IL4, IL3, IL5, CCL17, IL8
28montelukast44 49 28 1111.9CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
29prednisolone44 28 1110.7IGHE, SFTPD, CCL11, CCL3, EPX, RNASE3
30pgd2448.6IL5, IL13, CCL11, CCR3, PRG2, IGHE
31heparin44 28 11 2411.6RNASE3, PRG2, CCR3, CCL3, CCL11, EPX
32ltc4448.6PRG2, EPX, CYSLTR1, RNASE3, IL13, IL3
33salbutamol44 49 28 11 2412.5CCL11, PDE4A, IGHE, EPX, CYSLTR1, RNASE3
34tacrolimus44 49 1110.5CCL11, CCL17, CCL3, IL4, GGT1, IL5
35methacholine44 119.4IL8, CCL11, CCL3, PRG2, IGHE, RNASE3
36allergens448.4PRG2, IGHE, EPX, RNASE3, IL13, IL5
37budesonide44 49 1110.4CCL11, SFTPD, PDE4A, IGHE, EPX, RNASE3
38tarc448.2CCL11, CCL17, CCL3, CCR3, CCL7, IGHE
39thymidine44 249.1SERPINA1, CCL3, CCR3, SFTPD, CCL11, IL13
40leukotriene b444 59 2410.1CCL3, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
41fmlp448.0CCL11, CCL3, CCL7, PDE4A, PRG2, EPX
42polysaccharide447.9SERPINA1, GGT1, IL3, IGHE, CCL3, SFTPD
43lactate447.8SFTPD, IL8, IGHE, IL3, IL13, RNASE3
44nitric oxide44 11 249.8SFTPD, EPX, PRG2, RNASE3, PDE4A, IL13
45cyclosporin a44 28 599.7IL5, CCL11, CCL17, RNASE3, IGHE, PDE4A
46actinomycin d447.5CCL11, CCL3, CCR3, CCL7, PDE4A, PRG2
47cysteine447.5CCL3, CCR3, SFTPD, PRG2, EPX, IL3
48tyrosine447.3RNASE3, SERPINA1, IL4, PDE4A, IL5, CYSLTR1
49histamine44 28 248.6CCR3, CCL7, SFTPD, PDE4A, PRG2, IGHE
50dexamethasone44 49 28 119.2CCL7, SFTPD, PDE4A, EPX, CYSLTR1, RNASE3

GO Terms for genes affiliated with Pulmonary Eosinophilia

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16Gene Ontology
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Cellular components related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CCL17, CCL3, CCR3, CCL7, SFTPD, IL13
2extracellular regionGO:0055765.9SERPINA1, CCL11, CCL17, CCL3, CCL7, SFTPD

Biological processes related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCL11, CCR3
2regulation of proton transportGO:01015510.1IL13, IL4
3positive regulation of B cell proliferationGO:03089010.0IL4, IL5, IL13
4positive regulation of natural killer cell chemotaxisGO:20005039.9CCL3, CCL7
5positive regulation of angiogenesisGO:0457669.7CCL11, CCR3, CYSLTR1
6eosinophil chemotaxisGO:0482459.6CCL11, CCL3, CCR3, CCL7
7cellular calcium ion homeostasisGO:0068749.6CCL7, CCL3, CCL11
8cytoskeleton organizationGO:0070109.6CCL7, CCL3, CCL11
9macrophage chemotaxisGO:0482469.6SFTPD, CCL3
10cell-cell signalingGO:0072679.2CCL17, CCL3, CCL7, IL13, IL3
11inflammatory responseGO:0069548.5CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
12chemotaxisGO:0069358.3CCL11, CCL17, CCL3, CCR3, CCL7, CYSLTR1
13immune responseGO:0069558.0IL8, CCL11, CCL17, CCL7, PRG2, IGHE

Molecular functions related to Pulmonary Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.7CCL7, CCL3
2pancreatic ribonuclease activityGO:0045229.7RNASE2, RNASE3
3cytokine activityGO:0051259.5IL13, IL3, IL5, IL4
4ribonuclease activityGO:0045409.4RNASE2, RNASE3
5chemokine activityGO:0080099.2IL8, CCL7, CCL3, CCL17, CCL11

Products for genes affiliated with Pulmonary Eosinophilia

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  • Antibodies
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Sources for Pulmonary Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet