MCID: PLM036
MIFTS: 66

Pulmonary Fibrosis malady

Respiratory diseases category

Summaries for Pulmonary Fibrosis

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. this tissue gets thick and stiff. that makes it hard for you to catch your breath, and your blood may not get enough oxygen. causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective tissue diseases, and interstitial lung disease. interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. in most cases, the cause cannot be found. this is called idiopathic pulmonary fibrosis. symptoms include shortness of breath a dry, hacking cough that doesn't get better fatigue weight loss for no known reason aching muscles and joints clubbing, which is the widening and rounding of the tips of the fingers or toes your doctor may use your medical history, imaging tests, a biopsy, and lung function tests to diagnose pulmonary fibrosis. there is no cure. treatments can help with symptoms and improve your quality of life. they include medicines, oxygen therapy, pulmonary rehabilitation, or a lung transplant. nih: national heart, lung, and blood institute

MalaCards: Pulmonary Fibrosis, also known as post-inflammatory pulmonary fibrosis, is related to idiopathic pulmonary fibrosis and pneumonia. An important gene associated with Pulmonary Fibrosis is SFTPA2 (surfactant protein A2), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The drug oxygen and the compounds calcium and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related mouse phenotypes are immune system and mortality/aging.

Wikipedia:63 Pulmonary fibrosis is the formation or development of excess fibrous connective tissue (fibrosis) in the... more...

Aliases & Classifications for Pulmonary Fibrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary fibrosis 8 10 44 33 30 60
post-inflammatory pulmonary fibrosis 60
postinflammatory pulmonary fibrosis 8
lung: cirrhosis of 8
fibrosis of lung 8


External Ids:

Disease Ontology8 DOID:3770
MeSH34 D011658
NCIt39 C26869

Related Diseases for Pulmonary Fibrosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis Pulmonary Fibrosis, Familial
Terc-Related Familial Pulmonary Fibrosis Tert-Related Familial Pulmonary Fibrosis
Sftpc-Related Familial Pulmonary Fibrosis

Diseases related to Pulmonary Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic pulmonary fibrosis32.0TERC, SFTPA1
2pneumonia31.2ELANE, GRP, SOD3, SFTPD, SFTPC, CCL3
3pulmonary emphysema31.0ELANE, SFTPD
4sarcoidosis31.0CCL3, CCL18, CCR4, GRP, SFTPD, PDGFB
5pulmonary sarcoidosis31.0CCR4, CXCR3, PDGFB, SFTPD, CCL3
6pulmonary fibrosis, familial31.0TERC, TERT
7lung cancer30.9PDGFB, TERT, SFTPC, GRP, TERC, MMP7
8interstitial lung disease30.7CCL17, CCL3, SFTPC, GRP, SFTPD, PDGFB
9arthritis30.5CXCR3, SOD3, CCL3
10rheumatoid arthritis30.4CCL3, SFTPD, SOD3, CXCR3, TERT, CCL18
11pulmonary alveolar proteinosis30.4SFTPC, SFTPD
12eosinophilia30.3CCL17, CCR4
13pulmonary eosinophilia30.3SFTPD, CCL3
14cystic fibrosis30.2SFTPC, CCL22, ELANE, MUC5B, SFTPD, CCL17
15dermatomyositis30.2SFTPD, CCL3
16extrinsic allergic alveolitis30.2SFTPD, CCL3
17asthma30.1MUC5B, CCR4, CCL22, CCL17, CCL3, SFTPC
18influenza30.1SFTPD, CXCR3, CCL18
19hepatitis30.1PDGFB, HGF
20bronchiolitis obliterans30.1PDGFB, CXCR3
21bronchiolitis30.1CCL3
22breast cancer29.9TERC, TERT, CXCR3, HGF, CCL3, GRP
23squamous cell carcinoma29.9MMP7, PDGFB, HGF, TERC, GRP, TERT
24allergic asthma29.9CCR4, CCL17, CCL3, SFTPD
25liver cirrhosis29.9TERC, MMP7, PDGFB, HGF
26vascular disease29.9SOD3, PDGFB, GRP, ELANE
27adult respiratory distress syndrome29.9ELANE, SFTPD, SFTPC
28hepatitis c29.9CXCR3, MMP7
29vasculitis29.9ELANE
30myeloma29.8CCL3, HGF
31respiratory failure29.8SFTPC, SFTPD
32diffuse pulmonary fibrosis10.8
33idiopathic interstitial pneumonia10.7
34pulmonary systemic sclerosis10.7
35hypertension10.6
36hermansky-pudlak syndrome10.5
37nonspecific interstitial pneumonia10.5
38localized pulmonary fibrosis10.4
39acute interstitial pneumonia10.4
40connective tissue disease10.4
41asbestosis10.4
42scleroderma10.3
43postinflammatory pulmonary fibrosis10.2
44collagen disease10.2
45pneumothorax10.2
46combined pulmonary fibrosis-emphysema syndrome10.2
47desquamative interstitial pneumonia10.2
48dyskeratosis congenita10.2
49lymphangioleiomyomatosis10.2
50pneumoconiosis10.2

Graphical network of the top 20 diseases related to Pulmonary Fibrosis:



Diseases related to pulmonary fibrosis

Clinical Features for Pulmonary Fibrosis

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Drugs & Therapeutics for Pulmonary Fibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Fibrosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Fibrosis

Search NIH Clinical Center for Pulmonary Fibrosis

Search CenterWatch for Pulmonary Fibrosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Fibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Fibrosis:
Mesenchymal stem cells for lung fibrosis
Embryonic/Adult Cultured Cells Related to Pulmonary Fibrosis:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 20801416, 17569781, 18625757

Genetic Tests for Pulmonary Fibrosis

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Anatomical Context for Pulmonary Fibrosis

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Fibrosis:

32
Lung, Testes, Heart, Bone, Endothelial, T cells, Bone marrow, Monocytes, Smooth muscle, Colon, B cells, Skin, Liver, Myeloid, Breast, Thyroid, Skeletal muscle, Thymus, Brain, Nk cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pulmonary Fibrosis:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease

Animal Models for Pulmonary Fibrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pulmonary Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8ELANE, CCR4, CCL17, CCL3, SFTPC, SFTPD
2MP:001076811.5SFTPD, SFTPC, CCL3, HGF, SOD3, PDGFB
3MP:000539711.3CCR4, CCL3, SFTPD, PDGFB, TERT, TERC
4MP:000200610.8SFTPC, CXCR3, MMP7, TERT, TERC, ELANE

Publications for Pulmonary Fibrosis

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Sources:
50PubMed
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Articles related to Pulmonary Fibrosis:

(show top 50)    (show all 1501)
idTitleAuthorsYear
1
Clinical trials in idiopathic pulmonary fibrosis: a framework for moving forward. (24293416)
2013
2
Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2. (23656969)
2013
3
Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. (24089408)
2013
4
Effect of antisense TIMP-1 cDNA on the expression of TIMP-1 and MMP-2 in lung tissue with pulmonary fibrosis induced by bleomycin. (23124168)
2013
5
Locally instilled tumor necrosis factor I+ antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary fibrosis via induced CD4(+) CD25(+) Foxp3(+) regulatory T cells. (24339053)
2013
6
Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis. (23576879)
2013
7
Ambrisentan for pulmonary fibrosis. (24043636)
2013
8
Steep barriers to overcome for successful application of stem cell treatment in patients with idiopathic pulmonary fibrosis. (23855695)
2013
9
Targeting platelet-derived growth factor as a therapeutic approach in pulmonary fibrosis. (24190033)
2013
10
Use of a genealogical database demonstrates heritability of pulmonary fibrosis. (23867963)
2013
11
Content validity of CASA-Q cough domains and UCSD-SOBQ for use in patients with Idiopathic Pulmonary Fibrosis. (24171881)
2013
12
In this issue - July 2013: Dingoes and sheep don't mix A^ Septic arthritis after joint injections A^ Equine multinodular pulmonary fibrosis A^ Optimal position for ECG measurements A^ Multiple tumours in a dog A^ Dogs and sea hares don't mix either A^ Buruli ulcers in alpacas. (23782017)
2013
13
An update on idiopathic pulmonary fibrosis. (23676953)
2013
14
Molecular magnetic resonance imaging of pulmonary fibrosis in mice. (23927643)
2013
15
Should we screen for pulmonary hypertension at the initial evaluation of idiopathic pulmonary fibrosis? (23548546)
2013
16
Familial idiopathic pulmonary fibrosis. (23835999)
2013
17
Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation. (24131041)
2013
18
A microRNA processing defect in rapidly progressing idiopathic pulmonary fibrosis; enteral omega-3 fatty acid, I^-linoleic acid, and antioxidant supplementation in ALI; and management of asthma in pregnancy guided by exhaled nitric oxide. (22942345)
2012
19
Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis. (22448327)
2012
20
Incidence and prevalence of idiopathic pulmonary fibrosis: review of the literature. (23204124)
2012
21
A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis. (22561965)
2012
22
The hedgehog system machinery controls transforming growth factor-I^-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. (23031257)
2012
23
The role of proteinase-activated receptor-2 in idiopathic pulmonary fibrosis: is there really novel therapeutic potential here? (22336682)
2012
24
Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. (21193404)
2011
25
Viral infection in acute exacerbation of idiopathic pulmonary fibrosis. (21471095)
2011
26
Pirfenidone for the treatment of Hermansky-Pudlak syndrome pulmonary fibrosis. (21420888)
2011
27
Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis. (21616999)
2011
28
The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. (21373184)
2011
29
Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes. (19404954)
2009
30
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. (18641127)
2008
31
Complex regulation of pulmonary inflammation and fibrosis by CCL18. (17569779)
2007
32
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. (16809784)
2006
33
Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (16085216)
2005
34
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis. (14998687)
2004
35
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
36
A study of the cough reflex in idiopathic pulmonary fibrosis. (12917229)
2003
37
Pulmonary transplantation for cystic fibrosis: pre-transplant recipient characteristics in patients dying of peri-operative sepsis. (12873544)
2003
38
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. (11983918)
2002
39
Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis. (12204879)
2002
40
Direct measurement of IGF-I and IGFBP-3 in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis. (11817709)
2001
41
Granulocyte-colony stimulating factor levels in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis. (10525561)
1999
42
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis. (10543276)
1999
43
Serum level of interleukin 8 is elevated in idiopathic pulmonary fibrosis and indicates disease activity. (9517588)
1998
44
HRCT evident fibrosis in isolated pulmonary emphysema. (9071310)
1997
45
Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. (8325116)
1993
46
Scanning electron microscopic analysis of mineral fiber content of lung tissue in the evaluation of diffuse pulmonary fibrosis. (2052931)
1991
47
Rheumatoid lung disease; granulomas, fibrosis, pulmonary effusion. (1055882)
1975
48
Eosinophilic gastroenteritis with malabsorption, extensive villous atrophy, recurrent hemorrhage and chronic pulmonary fibrosis. (1080012)
1975
49
Diffuse pulmonary fibrosis [abstract]. (20919055)
1968
50
Rheumatoid disease with unusual pulmonary manifestations. Pulmonary hemosiderosis, fibrosis, and concretions. (5835358)
1965

Genetic Variations for Pulmonary Fibrosis

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Expression for genes affiliated with Pulmonary Fibrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Fibrosis

Search GEO for disease gene expression data for Pulmonary Fibrosis.

Pathways for genes affiliated with Pulmonary Fibrosis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3HGF, CCL22, CCR4, CCL18, CCL17, CCL3
2
Hide members
11.3HGF, CXCR3, PDGFB, CCL3, CCL17, CCL18
3
Hide members
11.3PDGFB, CCL3, CCL17, CCL18, CCR4, CCL22
4
Hide members
11.3HGF, CCL22, CCR4, CCL18, CCL17, CCL3
5
Hide members
11.2CCL22, CCR4, CCL18, CCL17, CCL3, CXCR3
6
Hide members
11.1HGF, CCL22, CCL18, CCL17, CCL3, PDGFB
7
Hide members
11.1CCL22, CCR4, CCL17, CCL3, GRP, CXCR3
8
Hide members
11.1CCL22, CCR4, CCL18, CCL17, CCL3, CXCR3
911.0CXCR3, CCL3, CCL17, CCR4, CCL22
1010.9CCL3, SFTPD, SOD3, ELANE
1110.8SFTPA1, SFTPA2, SFTPD
1210.8SFTPD, SFTPA2, SFTPA1
1310.7MMP7, HGF

Compounds for genes affiliated with Pulmonary Fibrosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.4GRP, SFTPA2, CCL18, CCL3, CCL17, CCR4
2vegf4412.0SOD3, CCL3, TERT, MMP7, CCL18, CXCR3
3retinoic acid44 2412.9SFTPC, CCL3, ELANE, TERC, TERT, MMP7
4thymidine44 2412.8TERC, TERT, CXCR3, GRP, PDGFB, SFTPD
5nitric oxide44 11 2413.7TERT, SFTPD, CCL3, CXCR3, SOD3, PDGFB
6lipid4411.7PDGFB, HGF, CCR4, SFTPC, SFTPD, SOD3
7ccl444 2812.7HGF, CXCR3, CCL3, CCL17, CCL18, CCL22
8dexamethasone44 49 28 1114.7CCL17, HGF, CCL18, SFTPC, SFTPD, PDGFB
9oxygen44 2412.7HGF, CCL3, TERT, SOD3, SFTPC, SFTPD
10paraffin4411.6HGF, TERC, MMP7, GRP, PDGFB, TERT
11larc4411.6CCR4, CCL18, CCL17, CCL3, CXCR3, CCL22
12tarc4411.6CCL3, CXCR3, CCL18, CCL22, CCL17, CCR4
13ccl344 2812.6CCL17, CCL18, CCL22, CCR4, CCL3, CXCR3
14cysteine4411.5ELANE, TERT, MMP7, SOD3, SFTPC, CCL3
15tacrolimus44 49 1113.5HGF, CCL17, CCL3, CXCR3, PDGFB, CCL22
16ribonucleic acid4411.5CCR4, CCL3, TERT, SFTPC, MMP7, PDGFB
17histamine44 28 2413.5CXCR3, CCL3, HGF, SFTPD, GRP, CCL22
18cyclosporin a44 28 5913.5PDGFB, HGF, CCL17, CCL3, ELANE, CCL22
19h2o24411.5MMP7, SOD3, CCL3, HGF, ELANE, TERT
20oligonucleotide4411.4CCL22, TERC, SFTPD, PDGFB, MMP7, TERT
21matrigel4411.4HGF, CCL3, MMP7, CXCR3, GRP
22etoposide44 49 59 1114.4HGF, CCL3, GRP, TERC, TERT
23fibrinogen4411.4CCL22, CCL17, SFTPC, MMP7, ELANE
24pd 98,0594411.3PDGFB, HGF, CCL3, CXCR3, TERT
25wortmannin4411.3TERT, HGF, CCL3, GRP, CXCR3
26doxorubicin44 49 1113.3TERT, TERC, MMP7, GRP, HGF
27arginine4411.3GRP, SOD3, TERT, CXCR3, SFTPC, HGF
28serine4411.3SOD3, CCL3, CXCR3, PDGFB
29bleomycin44 1112.3SFTPC, PDGFB, HGF, CCL3
30sodium nitroprusside4411.3ELANE, HGF, SOD3, CXCR3
31phosphatidylinositol4411.3HGF, MMP7, SFTPD, CXCR3, GRP, TERT
32prednisolone44 28 1113.3HGF, SFTPD, CCR4, CCL3
33heparan sulfate44 2412.2HGF, SOD3, CXCR3, CCL3
34lactate4411.1SFTPD, ELANE, CCL3, GRP, HGF
35rantes4411.1CCL3, CXCR3
36hydrocortisone44 2 59 1114.1ELANE, GRP
37sivelestat sodium hydrate4411.0SFTPD, ELANE
38il 104411.0CCL3, CCL17, CXCR3
39curosurf4411.0SFTPC, ELANE
40pge24411.0GRP
41methacholine44 1112.0GRP, CCL3, CCL22
42sivelestat4410.9ELANE, SFTPD
43egcg4410.9ELANE
44survanta4410.9SFTPC, ELANE
45aspirin44 49 28 2413.9HGF, CCL22, GRP, ELANE
46dextran sulfate4410.9HGF, MMP7, ELANE
47endotoxin4410.9CXCR3
485fluorouracil4410.8HGF, CCL3, TERC, TERT
49cerulein4410.7ELANE, GRP
50agar4410.6PDGFB, HGF, GRP, TERC

GO Terms for genes affiliated with Pulmonary Fibrosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.8MMP7, HGF, CCL22, CCL18, CCL17, CCL3
2extracellular regionGO:00557611.5SFTPA1, CCL3, CCL17, CCL22, HGF, SFTPA2
3collagenGO:00558110.8SFTPD, SFTPA2, SFTPA1

Biological processes related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693511.3CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22
2inflammatory responseGO:00695411.3CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22
3respiratory gaseous exchangeGO:00758511.1SFTPA1, SFTPA2, SFTPC, SFTPD
4positive chemotaxisGO:05091810.9HGF, CCL3, PDGFB
5cell-cell signalingGO:00726710.9CCL22, CCL18, CCL17, CCL3
6T cell chemotaxisGO:01081810.8CXCR3, CCL3
7positive regulation of cell migrationGO:03033510.8PDGFB, CCL3, HGF
8positive regulation of DNA biosynthetic processGO:200057310.8PDGFB, HGF
9macrophage chemotaxisGO:04824610.6SFTPD, CCL3
10monocyte chemotaxisGO:00254810.4PDGFB, CCL3

Molecular functions related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.8PDGFB, CCL3, HGF
2chemokine activityGO:00800910.6CCL3, CCL17, CCL18, CCL22

Products for genes affiliated with Pulmonary Fibrosis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Pulmonary Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet