MCID: PLM036
MIFTS: 68

Pulmonary Fibrosis malady

Genetic diseases (common), Respiratory diseases categories

Summaries for Pulmonary Fibrosis

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MedlinePlus:33 Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. this tissue gets thick and stiff. that makes it hard for you to catch your breath, and your blood may not get enough oxygen. causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective tissue diseases, and interstitial lung disease. interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. in most cases, the cause cannot be found. this is called idiopathic pulmonary fibrosis. symptoms include shortness of breath a dry, hacking cough that doesn't get better fatigue weight loss for no known reason aching muscles and joints clubbing, which is the widening and rounding of the tips of the fingers or toes your doctor may use your medical history, imaging tests, a biopsy, and lung function tests to diagnose pulmonary fibrosis. there is no cure. treatments can help with symptoms and improve your quality of life. they include medicines, oxygen therapy, pulmonary rehabilitation, or a lung transplant. nih: national heart, lung, and blood institute

MalaCards based summary: Pulmonary Fibrosis, also known as fibrosis of lung, is related to idiopathic pulmonary fibrosis and interstitial lung disease. An important gene associated with Pulmonary Fibrosis is SFTPA2 (surfactant protein A2), and among its related pathways are FOXA1 transcription factor network and Phagosome. The drug oxygen and the compounds sivelestat sodium hydrate and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related mouse phenotypes are tumorigenesis and growth/size/body.

Wikipedia:64 Pulmonary fibrosis (literally \"scarring of the lungs\") is a respiratory disease in which scars are... more...

Aliases & Classifications for Pulmonary Fibrosis

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Pulmonary Fibrosis, Aliases & Descriptions:

Name: Pulmonary Fibrosis 31 9 11 44 33 61
Fibrosis of Lung 9 61
Post-Inflammatory Pulmonary Fibrosis 61
 
Postinflammatory Pulmonary Fibrosis 9
Lung: Cirrhosis of 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:3770
NCIt39 C26869
MeSH34 D011658

Related Diseases for Pulmonary Fibrosis

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Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis Pulmonary Fibrosis, Familial
Terc-Related Familial Pulmonary Fibrosis Tert-Related Familial Pulmonary Fibrosis
Sftpc-Related Familial Pulmonary Fibrosis

Diseases related to Pulmonary Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic pulmonary fibrosis32.8TERC, MUC5B
2interstitial lung disease31.6SFTPD
3pulmonary fibrosis, familial31.3TERT, TERC
4chronic obstructive pulmonary disease31.1SFTPD, MUC5B
5pulmonary alveolar proteinosis31.0SFTPD, SFTPC
6dyskeratosis congenita30.9TERC, TERT
7bronchitis30.9MUC5B
8lung cancer30.8TERT, TERC, SFTPC, MMP7, PDGFB, GRP
9pulmonary emphysema30.8ELANE, SFTPD
10bronchiolitis30.8CCL3
11extrinsic allergic alveolitis30.7CCL3, SFTPD
12bronchiolitis obliterans30.4CXCR3, PDGFB
13adult respiratory distress syndrome30.3ELANE, SFTPC, SFTPD
14contact dermatitis30.3CXCR3, CCR4
15pulmonary eosinophilia30.3SFTPD, CCL3
16vascular disease30.3SOD3, ELANE
17pneumonia30.3SFTPD, SFTPC, SOD3, ELANE, CCL3, CCL17
18respiratory failure30.2CCL17, ELANE, SFTPD
19systemic scleroderma30.2CTGF
20sarcoidosis30.2SFTPD, CXCR3, CCL3, CCL18, CCR4, PDGFB
21arthritis30.1SOD3, CXCR3, CCL3, CTGF
22pulmonary sarcoidosis30.1SFTPD, CXCR3, CCL3, CCR4, PDGFB
23cystic fibrosis30.0SFTPD, SFTPC, MUC5B, ELANE, CCL17, CCL22
24influenza30.0CCL18, CXCR3, SFTPD
25glomerulonephritis29.9CTGF, PDGFB, ELANE
26allergic asthma29.9SFTPD, CCL3, CCL17, CCR4
27breast cancer29.9GRP, CCL3, MMP7, TERC, TERT
28dermatitis29.8CCL22, CCR4, CCL18, CCL17, CXCR3
29liver cirrhosis29.7CTGF, PDGFB, MMP7, TERC
30rheumatoid arthritis29.0TERT, SFTPD, SOD3, CXCR3, ELANE, CCL3
31asthma28.5SFTPD, SFTPC, MUC5B, CXCR3, ELANE, CCL3
32diffuse pulmonary fibrosis10.8
33hypertension10.6
34pulmonary hypertension10.6
35usual interstitial pneumonia10.6
36hermansky-pudlak syndrome10.6
37nonspecific interstitial pneumonia10.6
38paragonimiasis10.5CCL17
39dyskeratosis congenita autosomal dominant10.5TERC, TERT
40pustulosis palmaris et plantaris10.5ELANE
41connective tissue disease10.5
42microscopic polyangiitis10.4
43acute interstitial pneumonia10.4
44asbestosis10.4
45scleroderma10.4
46pulmonary function10.4
47gastritis10.4TERT, TERC
48endotheliitis10.4
49eosinophilic pneumonia10.3CCL17, CCL22
50adenosquamous carcinoma10.3GRP, SFTPC, SFTPD

Graphical network of the top 20 diseases related to Pulmonary Fibrosis:



Diseases related to pulmonary fibrosis

Symptoms for Pulmonary Fibrosis

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Drugs & Therapeutics for Pulmonary Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Fibrosis

Search NIH Clinical Center for Pulmonary Fibrosis

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Fibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Fibrosis:
Mesenchymal stem cells for lung fibrosis
Embryonic/Adult Cultured Cells Related to Pulmonary Fibrosis:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 20801416, 17569781, 18625757

Genetic Tests for Pulmonary Fibrosis

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Anatomical Context for Pulmonary Fibrosis

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MalaCards organs/tissues related to Pulmonary Fibrosis:

32
Lung, Testes, Heart, Neutrophil, Bone, Bone marrow, Monocytes, Endothelial, T cells, Smooth muscle, B cells, Skin, Thymus, Skeletal muscle, Liver, Thyroid, Breast, Myeloid, Nk cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Pulmonary Fibrosis:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease

Animal Models for Pulmonary Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Fibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6TERT, TERC, SFTPC, MMP7, CXCR3, ELANE
2MP:00053788.0TERC, SFTPD, SFTPC, MMP7, CCL3, PDGFB
3MP:00053887.9TERC, SFTPD, SFTPC, CXCR3, CCR4, PDGFB
4MP:00053767.2TERT, TERC, SFTPD, SOD3, MMP7, CXCR3
5MP:00107687.1SFTPC, SFTPD, TERC, TERT, SOD3, MMP7
6MP:00053977.0MMP7, SFTPD, TERC, TERT, CXCR3, ELANE
7MP:00053876.5PDGFB, TERT, TERC, SFTPD, SFTPC, SOD3

Publications for Pulmonary Fibrosis

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Articles related to Pulmonary Fibrosis:

(show top 50)    (show all 1331)
idTitleAuthorsYear
1
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. (23964118)
2014
2
Landmark approvals in idiopathic pulmonary fibrosis. (25380420)
2014
3
Hypoxia-induced Deoxycytidine Kinase Contributes to Epithelial Proliferation in Pulmonary Fibrosis. (25358054)
2014
4
Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study. (24002055)
2013
5
Echocardiographic and hemodynamic predictors of mortality in idiopathic pulmonary fibrosis. (23450321)
2013
6
Procollagen type III amino terminal propeptide concentrations in dogs with idiopathic pulmonary fibrosis compared with chronic bronchitis and eosinophilic bronchopneumopathy. (22909956)
2013
7
Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-I_B and activator protein-1. (23583295)
2013
8
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. (23315259)
2013
9
Pulmonary fibrosis in dyskeratosis congenita with TINF2 gene mutation. (24072216)
2013
10
Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis. (24268661)
2013
11
Detection of autoantibodies to periplakin and envoplakin in paraneoplastic pemphigus but not idiopathic pulmonary fibrosis using full-length recombinant proteins. (24275244)
2013
12
Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis. (23997916)
2013
13
Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. (23523661)
2013
14
Idiopathic pulmonary fibrosis in 2011: key updates on guidelines and therapeutics. Concluding remarks. (23735046)
2013
15
Oxidative stress and pulmonary fibrosis. (23219955)
2013
16
Pulmonary hypertension as a prognostic factor in idiopathic pulmonary fibrosis. (23485885)
2013
17
Pulmonary fibrosis in sarcoidosis. Clinical features and outcomes. (23952859)
2013
18
Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis. (24286160)
2013
19
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. (22157762)
2012
20
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. (22931326)
2012
21
Expressions of caveolin-1 and extracellular matrix in lung tissues of patients with idiopathic pulmonary fibrosis]. (22883991)
2012
22
Secondary prevention of idiopathic pulmonary fibrosis: catching the horse still in the barn. (22467803)
2012
23
Equine multinodular pulmonary fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report. (23009194)
2012
24
The natural history and diagnosis of idiopathic pulmonary fibrosis: are we all on the same page? (21729885)
2011
25
Safety of postoperative administration of human urinary trypsin inhibitor in lung cancer patients with idiopathic pulmonary fibrosis. (22216165)
2011
26
Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. (21246230)
2011
27
Intedanib, a triple kinase inhibitor of VEGFR, FGFR and PDGFR for the treatment of cancer and idiopathic pulmonary fibrosis. (20432191)
2010
28
Familial interstitial pulmonary fibrosis: a large family with atypical clinical features. (21165348)
2010
29
Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis. (20560296)
2009
30
Serum surfactant protein-A is a strong predictor of early mortality in idiopathic pulmonary fibrosis. (19255294)
2009
31
Increased bronchoalveolar lavage fluid CD1c expressing dendritic cells in idiopathic pulmonary fibrosis. (19556741)
2009
32
Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin. (17702637)
2007
33
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis. (17446530)
2007
34
RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis. (16776827)
2006
35
Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis. (16933466)
2006
36
CD8+ T lymphocytes in lung tissue from patients with idiopathic pulmonary fibrosis. (16042790)
2005
37
CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. (15802346)
2005
38
NOD2/CARD15 gene polymorphisms in idiopathic pulmonary fibrosis. (16315780)
2005
39
Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis. (15531774)
2004
40
Transforming growth factor-beta1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis. (12746254)
2003
41
A study of the cough reflex in idiopathic pulmonary fibrosis. (12917229)
2003
42
Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis. (11991086)
2002
43
Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis. (11790645)
2002
44
Overexpression of matrix metalloproteinase-7 in pulmonary fibrosis. (11893661)
2002
45
Direct measurement of IGF-I and IGFBP-3 in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis. (11817709)
2001
46
Interleukin-8 expression in bronchoalveolar lavage cells in the evaluation of alveolitis in idiopathic pulmonary fibrosis. (9616535)
1998
47
Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. (8325116)
1993
48
Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis. (8362967)
1993
49
TNF in autoimmune diseases, graft-versus-host reactions, and pulmonary fibrosis. (1550870)
1992
50
Diffuse pulmonary fibrosis [abstract]. (20919054)
1968

Variations for Pulmonary Fibrosis

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Expression for genes affiliated with Pulmonary Fibrosis

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LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Fibrosis patients vs. healthy controls: 31 (show all 87)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1BPIFB1BPI fold containing family B, member 1Lung+3.390.013
2KRT17keratin 17Lung+3.200.000
3SPP1secreted phosphoprotein 1Lung+3.150.000
4MMP7matrix metallopeptidase 7 (matrilysin, uterine)Lung+3.010.000
5DEFA1defensin, alpha 1Lung-2.850.000
6ITLN2intelectin 2Lung-2.800.000
7APLNRapelin receptorLung+2.580.000
8DEFA3defensin, alpha 3, neutrophil-specificLung-2.560.001
9SFRP2secreted frizzled-related protein 2Lung+2.550.000
10PLA2G1Bphospholipase A2, group IB (pancreas)Lung-2.530.001
11THY1Thy-1 cell surface antigenLung+2.490.000
12COMPcartilage oligomeric matrix proteinLung+2.430.000
13AGERadvanced glycosylation end product-specific receptorLung-2.410.000
14IL1RL1interleukin 1 receptor-like 1Lung-2.400.002
15KRT5keratin 5Lung+2.310.010
16CRTAC1cartilage acidic protein 1Lung-2.220.001
17CXCL10chemokine (C-X-C motif) ligand 10Lung+2.200.039
18GSTA1glutathione S-transferase alpha 1Lung+2.200.026
19COL1A1collagen, type I, alpha 1Lung+2.160.000
20PROK2prokineticin 2Lung-2.150.003
21PEBP4phosphatidylethanolamine-binding protein 4Lung-2.120.002
22VCAM1vascular cell adhesion molecule 1Lung+2.100.014
23SLNsarcolipinLung+2.070.008
24MMP11matrix metallopeptidase 11 (stromelysin 3)Lung+2.070.004
25RGS1regulator of G-protein signaling 1Lung+2.040.005
26ZNF385Bzinc finger protein 385BLung-2.030.005
27CA4carbonic anhydrase IVLung-2.010.019
28NFE2nuclear factor, erythroid 2Lung-2.000.001
29PROM2prominin 2Lung+1.970.007
30COL17A1collagen, type XVII, alpha 1Lung+1.970.004
31HSD17B6hydroxysteroid (17-beta) dehydrogenase 6Lung-1.970.005
32CCL3L3chemokine (C-C motif) ligand 3-like 3Lung+1.960.007
33FMO5flavin containing monooxygenase 5Lung-1.930.005
34CCL19chemokine (C-C motif) ligand 19Lung+1.930.012
35ALDH3A1aldehyde dehydrogenase 3 family, member A1Lung+1.930.027
36GATA2GATA binding protein 2Lung-1.890.001
37FOLR3folate receptor 3 (gamma)Lung-1.890.032
38PLLPplasmolipinLung-1.880.002
39DNAAF1dynein, axonemal, assembly factor 1Lung+1.860.041
40SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Lung+1.850.021
41COL7A1collagen, type VII, alpha 1Lung+1.850.008
42FAM83Dfamily with sequence similarity 83, member DLung+1.830.008
43CDH3cadherin 3, type 1, P-cadherin (placental)Lung+1.830.003
44FASNfatty acid synthaseLung-1.810.000
45PLCH2phospholipase C, eta 2Lung+1.810.013
46UBDubiquitin DLung+1.790.018
47CHI3L2chitinase 3-like 2Lung-1.720.007
48TP63tumor protein p63Lung+1.710.044
49RNASE2ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)Lung-1.700.023
50ABCA3ATP-binding cassette, sub-family A (ABC1), member 3Lung-1.690.018
51LAMP3lysosomal-associated membrane protein 3Lung-1.680.015
52IL8interleukin 8Lung+1.680.026
53PLA2G4Fphospholipase A2, group IVFLung-1.670.030
54CCL3chemokine (C-C motif) ligand 3Lung+1.660.036
55ACTG2actin, gamma 2, smooth muscle, entericLung+1.650.037
56CCL3L1chemokine (C-C motif) ligand 3-like 1Lung+1.640.021
57DIO2deiodinase, iodothyronine, type IILung+1.630.006
58SMAD6SMAD family member 6Lung-1.610.050
59ZBED2zinc finger, BED-type containing 2Lung-1.610.030
60MDKmidkine (neurite growth-promoting factor 2)Lung+1.600.002
61TMEM97transmembrane protein 97Lung-1.590.002
62LAMP5lysosomal-associated membrane protein family, member 5Lung+1.580.004
63FHL2four and a half LIM domains 2Lung+1.580.018
64CD1ACD1a moleculeLung+1.570.039
65CCL22chemokine (C-C motif) ligand 22Lung+1.570.016
66FNDC1fibronectin type III domain containing 1Lung+1.560.041
67MXRA5matrix-remodelling associated 5Lung+1.560.016
68TNFAIP3tumor necrosis factor, alpha-induced protein 3Lung+1.550.038
69CD24CD24 moleculeLung+1.550.047
70IL13RA2interleukin 13 receptor, alpha 2Lung+1.530.019
71ALDH1A3aldehyde dehydrogenase 1 family, member A3Lung+1.510.048
72COL15A1collagen, type XV, alpha 1Lung+1.510.049
73CTSKcathepsin KLung+1.510.035
74GPRIN2G protein regulated inducer of neurite outgrowth 2Lung-1.510.008
75SFTA2surfactant associated 2Lung-1.500.042
76FAM167Afamily with sequence similarity 167, member ALung-1.480.012
77MYRFmyelin regulatory factorLung-1.470.022
78MFSD2Amajor facilitator superfamily domain containing 2ALung-1.470.015
79CRABP2cellular retinoic acid binding protein 2Lung+1.470.030
80KCTD14potassium channel tetramerization domain containing 14Lung-1.460.022
81PLA2G3phospholipase A2, group IIILung-1.460.024
82CLDN2claudin 2Lung+1.450.013
83LRRC17leucine rich repeat containing 17Lung+1.410.024
84HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)Lung-1.410.030
85TRIB3tribbles pseudokinase 3Lung-1.380.023
86GPX3glutathione peroxidase 3 (plasma)Lung-1.350.042
87FADS1fatty acid desaturase 1Lung-1.320.044

Expression patterns in normal tissues for genes affiliated with Pulmonary Fibrosis

Search GEO for disease gene expression data for Pulmonary Fibrosis.

Pathways for genes affiliated with Pulmonary Fibrosis

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Pathways related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FOXA transcription factor networks37
9.9SFTPA2, SFTPA1, SFTPD
29.9SFTPA2, SFTPA1, SFTPD
39.1SFTPD, SOD3, ELANE, CCL3
4
Show member pathways
8.0CCL3, CCL17, CCL18, CCL22, PDGFB, CTGF
5
Show member pathways
7.7CXCR3, CCL3, CCL17, CCR4, CCL22, GRP
6
Show member pathways
7.6CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22
7
Show member pathways
7.6CCL22, CCR4, CCL18, CCL17, CCL3, CXCR3
8
Show member pathways
7.4MMP7, CXCR3, CCL3, CCL17, CCL18, CCR4
9
Show member pathways
7.3CXCR3, CCL3, CCL17, CCR4, CCL22, PDGFB
10
Show member pathways
7.2CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22
11
Show member pathways
6.8CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22
12
Show member pathways
6.8PDGFB, CCL22, CCR4, CCL18, CCL17, CCL3
13
Show member pathways
6.8CXCR3, CTGF, PDGFB, CCL22, CCR4, CCL18

Compounds for genes affiliated with Pulmonary Fibrosis

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Compounds related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate4410.3ELANE, SFTPD
2curosurf4410.3ELANE, SFTPC
3survanta4410.2ELANE, SFTPC
4sivelestat4410.2SFTPD, ELANE
5lipofectamine4410.1TERT, TERC
6allergens449.8SFTPD, CXCR3, CCL17
7cerulein449.7GRP, ELANE
8il 10449.6CXCR3, CCL3, CCL17
9peroxynitrite449.5SFTPC, SOD3, CCL3
10pioglitazone29 44 50 1212.5SOD3, MMP7, CTGF
11methacholine44 50 1211.5GRP, CCL3, CCL22
12endotoxin449.4CCL3, ELANE, CXCR3, SFTPD
13bleomycin44 1210.3CTGF, PDGFB, CCL3, SFTPC
14agar449.2PDGFB, TERC, CTGF, GRP
15etoposide44 50 60 1212.2CCL3, TERC, TERT, GRP
16fibrinogen449.2CCL17, SFTPC, MMP7, CCL22, CTGF, ELANE
17hydrocortisone44 3 60 1212.1GRP, CCL3, ELANE, CXCR3
18epinephrine44 25 1211.1GRP, ELANE, CCL22, CCL3
19tacrolimus44 50 1211.1CXCR3, PDGFB, CCL22, CCL3, CCL17
20matrigel449.0CCL3, CXCR3, MMP7, GRP
21pd 98,059449.0PDGFB, TERT, CTGF, CXCR3, CCL3
22histamine44 29 2511.0GRP, CCL22, CCL3, CXCR3, SFTPD
23oligonucleotide448.9CTGF, TERT, TERC, SFTPD, MMP7, CCL22
24heparin44 29 25 1211.9SOD3, CTGF, CCL3, ELANE, CXCR3
25phosphatidylinositol448.9CXCR3, GRP, TERT, SFTPD, CTGF, MMP7
26h2o2448.9SOD3, CTGF, ELANE, MMP7, TERT, CCL3
27lactate448.8CTGF, GRP, CCL3, SFTPD, ELANE
28cholesterol44 29 25 1211.7CCL3, CXCR3, SOD3, SFTPC, SFTPD
29cyclosporin a44 29 6010.7CTGF, PDGFB, CCL22, CCL17, ELANE, CCL3
30cycloheximide448.7CTGF, SFTPC, CCL3, PDGFB, GRP
31pge2448.5CXCR3, CTGF, GRP, CCL22, CCL3, ELANE
32paraffin448.4TERC, GRP, PDGFB, CCR4, MMP7, TERT
33cysteine448.4CTGF, TERT, ELANE, MMP7, SOD3, SFTPC
34ribonucleic acid448.1TERT, SFTPC, CTGF, PDGFB, CCR4, CCL3
35larc448.1CCR4, CCL22, CCL18, CCL17, CCL3, CXCR3
36thymidine44 259.1TERT, CCL3, SFTPD, CXCR3, PDGFB, GRP
37lipid448.1TERC, SFTPD, SFTPC, CCR4, PDGFB, CTGF
38tarc448.1CCL22, CCL3, CCR4, CCL18, CXCR3, CCL17
39ccl344 299.1CXCR3, CCR4, CCL3, CCL17, CCL18, CCL22
40ccl444 299.1CCL18, CCL22, CCL17, CCR4, CCL3, CXCR3
41rantes448.0CXCR3, CCL3, CCL17, CCL22, CCL18, CCR4
42nitric oxide44 25 1210.0TERT, CCL17, SFTPD, SOD3, MMP7, CXCR3
43estrogen447.7TERT, CXCR3, MMP7, CTGF, GRP, PDGFB
44oxygen44 258.7ELANE, TERT, SFTPD, SFTPC, SOD3, PDGFB
45retinoic acid44 258.4GRP, CCL3, CCR4, CTGF, MMP7, TERT
46serine447.4CXCR3, GRP, PDGFB, SFTPD, CCL3, TERT
47tyrosine447.2CTGF, CCR4, CXCR3, MMP7, TERT, PDGFB
48vegf447.1MMP7, CCL18, PDGFB, GRP, SOD3, CTGF
49dexamethasone44 50 29 1210.1CCL18, CCL3, GRP, PDGFB, CCL22, CXCR3
50calcium44 50 25 128.9CCL18, CCL22, CCL17, GRP, CXCR3, SFTPA2

GO Terms for genes affiliated with Pulmonary Fibrosis

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Cellular components related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.9SFTPA2, SFTPA1, SFTPD
2extracellular regionGO:0055766.1MUC5B, SOD3, SFTPA2, SFTPA1, SFTPD, MMP7
3extracellular spaceGO:0056156.0CTGF, SFTPD, SFTPA1, SFTPC, SFTPA2, SOD3

Biological processes related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.9SFTPD, SFTPA1, SFTPC, SFTPA2
2positive regulation of chemotaxisGO:0509219.8PDGFB, CXCR3
3T cell chemotaxisGO:0108189.8CCL3, CXCR3
4reactive oxygen species metabolic processGO:0725939.7SFTPD, PDGFB, CTGF
5macrophage chemotaxisGO:0482469.6SFTPD, CCL3
6positive chemotaxisGO:0509189.5PDGFB, CCL3
7monocyte chemotaxisGO:0025489.2PDGFB, CCL3
8positive regulation of ERK1 and ERK2 cascadeGO:0703749.2CCL3, PDGFB, CTGF
9cell chemotaxisGO:0603269.1PDGFB, CCL22, CCL18, CCL17
10cell-cell signalingGO:0072678.9CCL3, CCL17, CCL18, CCL22
11immune responseGO:0069558.5CCL22, CCR4, CCL18, CCL17
12chemotaxisGO:0069357.9CCL22, CCR4, CCL18, CCL17, CCL3, CXCR3
13inflammatory responseGO:0069547.9CXCR3, CCL3, CCL17, CCL18, CCR4, CCL22

Molecular functions related to Pulmonary Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.6SFTPA2, SFTPA1, SFTPD
2chemoattractant activityGO:0420569.5PDGFB, CCL3
3heparin bindingGO:0082019.4SOD3, ELANE, CTGF
4chemokine receptor activityGO:0049509.3CCR4, CXCR3
5chemokine activityGO:0080098.9CCL22, CCL18, CCL17, CCL3

Products for genes affiliated with Pulmonary Fibrosis

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