Pulmonary Fibrosis malady

MedlinePlus: Pulmonary fibrosis harms the tissues deep in your lungs. the air sacs in your lungs and their supporting structures become scarred and make your lungs thick and stiff. that makes it hard for you to catch your breath, and your blood may not get enough oxygen. one cause of pulmonary fibrosis is interstitial lung disease. interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. pulmonary fibrosis is also associated with some connective tissue diseases. it can be a side effect of a medicine. sometimes no one knows the cause of the disease. smoking can boost your risk or make your illness worse²³

MalaCards: Pulmonary Fibrosis, also known as post-inflammatory pulmonary fibrosis, is related to fibrosis and idiopathic pulmonary fibrosis. An important gene associated with Pulmonary Fibrosis is SFTPA1 (surfactant protein A1), and among its related pathways are Akt Signaling and Cytokine-cytokine receptor interaction. The drugs acetylcysteine and sucralfate and the compounds calcium and ribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and smooth muscle, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia: Pulmonary fibrosis is the formation or development of excess fibrous connective tissue (fibrosis) in the...⁴⁴ more...

Aliases & Descriptions:

pulmonary fibrosis 6 7 17 8 32 23 43 post-inflammatory pulmonary fibrosis 43 postinflammatory pulmonary fibrosis 6 fibrosis of lung (disorder) 6

lung: cirrhosis of 6 pneumonia 43 fibrosis 43

Diseases related to pulmonary fibrosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1191)

id	Related Disease	Score	Top Affiliating Genes
1	fibrosis	42.2	NCF1, NCF2, RETNLB, VWF, SFTPA1, SFTPA2
2	idiopathic pulmonary fibrosis	40.9	MPO, MMP1, MMP2, MMP7, FN1, FGF2
3	sarcoidosis	38.1	SFTPD, SELE, VIM, VEGFA, CMA1, CLEC12A
4	klebsiella	38.1	SFTPD, MPO, MMP9, IL1B, IL1R1, IL1RAPL2
5	pneumonia	36.5	SFTPA1, SFTPB, SFTPC, SFTPD, SELE, SETD2
6	hepatitis b	34.9	IL10, IL12B, IL18, IL2RA, CCR5, IFNG
7	eosinophilic pneumonia	34.8	IL13, IL3, IL5, CCL22, CCL11, CCL17
8	insulin resistance	34.5	RETNLB, VWF, SFTPA1, SELE, SETD2, SEPP1
9	emphysema	34.4	SFTPB, SFTPC, SFTPD, SERPINA1, SERPINE1, SERPINB1
10	oral submucous fibrosis	34.3	CD36, MMP1, MMP2, MMP3, MICA, FGF2
11	nephropathy	34.3	VWF, SELE, SERPINA1, SERPINE1, VEGFA, BMP4
12	aspergillosis	34.3	NCF2, SFTPA1, SFTPA2, SFTPD, IL10, IL1A
13	sepsis	34.1	SFTPD, SELE, SERPINE1, MPO, CDKN3, MIF
14	chronic obstructive pulmonary disease	34.1	SFTPB, SFTPD, SERPINA1, SERPINB1, SCGB1A1, MPO
15	acute interstitial pneumonia	33.7	SFTPC, SFTPD, SCGB1A1, S100A1, MMP7, IL13
16	cystic fibrosis lung disease	33.6	SERPINA1, SCGB1A1, MUC5B, MPO, IL10, IL1A
17	pulmonary sarcoidosis	33.6	SFTPD, IL12B, IL18, IL2, IL2RA, IL2RB
18	allergic bronchopulmonary aspergillosis	33.5	SFTPA1, SFTPA2, SFTPD, IL10, IL4, IL5
19	bronchiolitis obliterans	33.2	SFTPA1, SFTPD, BMP6, SCGB1A1, MUC1, MMP7
20	nonalcoholic steatohepatitis	33.2	SERPINE1, BMP6, MPO, IL1B, IL6, IL8
21	influenza	33.1	SFTPA1, SFTPD, SERPINE1, MPO, JUN, CD28
22	interstitial lung disease	33.0	SFTPB, SFTPC, SFTPD, BMP6, GRP, IL1A
23	chronic eosinophilic pneumonia	33.0	IL10, IL5, CCL11, RNASE3, CXCL9, CXCR3
24	asthma	32.8	SERPINE1, SCGB1A1, MPO, IL12B, IL13, IL1B
25	usual interstitial pneumonia	32.8	SFTPC, FGF2, IL13, IL8, CCL7, CCL2
26	fatty liver disease	32.8	SELE, SERPINA1, SERPINE1, BMP6, XBP1, JUN
27	septic shock	32.7	SFTPB, SELE, SERPINE1, MIF, IL10, IL12B
28	bronchiolitis	32.4	NCF2, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
29	haemophilus influenzae	32.3	MPO, FN1, IL10, IL1A, IL1B, IL2RA
30	glomerulonephritis	32.3	VWF, SERPINE1, SERPINB1, VIM, VEGFA, VCAN
31	atherosclerosis	32.2	NCF1, NCF2, VWF, SFTPB, SELE, SETD2
32	nonspecific interstitial pneumonia	32.2	SFTPC, FGF2, IL13, IL18, IL6, IL8
33	pulmonary function	32.2	SFTPB, SERPINA1, MPO, CD36, IL10, IL13
34	biliary atresia	32.0	SELE, SERPINE1, VEGFA, CD36, MMP2, MMP3
35	systemic scleroderma	31.8	VWF, SFTPD, SELE, BMP6, S100A9, CD28
36	myelofibrosis	31.7	VEGFA, BMP6, KDR, MPO, FN1, FGF2
37	idiopathic interstitial pneumonia	31.7	SFTPC, SFTPD, SERPINE1, VEGFA, CMA1, SCGB1A1
38	aldosteronism	31.7	SERPINE1, VEGFA, BMP4, BMP6, CMA1, JUN
39	hermansky-pudlak syndrome	31.6	VWF, SFTPB, BLOC1S3, CD63, AP3B1, CCL2
40	tuberculosis	31.6	IL10, IL12B, IL1B, IL1RN, IL4, CCL2
41	down syndrome	31.5	SERPINE1, VEGFA, BMP6, S100A1, MPO, CD36
42	carcinoma	31.4	NCF2, RETNLB, VWF, SFTPA1, SFTPB, SFTPC
43	viral hepatitis	31.4	SERPINA1, CFLAR, MPO, CDKN2A, CDKN3, FN1
44	polymyositis	31.3	VWF, SFTPD, SELE, VEGFA, S100A9, JUN
45	ankylosing spondylitis	31.3	SERPINA1, MMP3, IL1R1, IL1RAPL2, IL1RN, HLA-B
46	meningitis	31.2	SELE, SERPINA1, VIM, VEGFA, BMP6, MUC1
47	eosinophilia	31.2	SFTPA1, SFTPA2, SFTPD, SERPINA1, MUC1, MPO
48	adult respiratory distress syndrome	31.0	SFTPB, SELE, SERPINA1, IL1R1, IL8, ALOX5
49	hepatic fibrosis renal cysts mental retardation	30.9	SERPINE1, BMP6, CD36, MMP1, MMP2, MMP3
50	liver cirrhosis	30.9	SERPINB3, SERPINA1, SEPP1, MMP3, FOS, IL11

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylcysteine, oxygen, potassium para-aminobenzoate, sparfloxacin, sucralfate

Cell-based therapeutics:

	Placenta-derived mesenchymal stem cells, PMIDs: 20801416, 15891110, 12815096
	Mesenchymal stem cell, PMIDs: 20801416, 15891110, 12815096

MalaCards organs/tissues related to pulmonary fibrosis:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Lung -> Alveoli -> Alveolar Epithelial Type 1 Cells	Potential therapeutic candidate, affected by disease
2	Lung -> Alveoli -> Alveolar Epithelial Type 2 Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to pulmonary fibrosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	VWF, SELE, SEMA7A, SEPP1, SERPINB1, VIM
2	mortality/aging	MP:0010768	INF	RETNLB, VWF, SFTPB, SFTPC, SFTPD, SELE
3	no phenotypic analysis	MP:0003012	INF	SFTPC, VEGFA, MYC, BMP4, MUC1, ATF6
4	hearing/vestibular/ear phenotype	MP:0005377	INF	MYC, BMP4, , BLOC1S6, LAMC2, FZD1
5	limbs/digits/tail phenotype	MP:0005371	INF	SEPP1, VEGFA, VCAN, BMP4, BLMH,
6	homeostasis/metabolism phenotype	MP:0005376	INF	RETNLB, VWF, SFTPB, SFTPD, SELE, SETD2
7	craniofacial phenotype	MP:0005382	INF	BMP4, , ATF4, FZD1, MMP16, MECP2
8	endocrine/exocrine gland phenotype	MP:0005379	11.2	GSN, MECP2, IL2, IL2RB, AQP5, IFNG
9	liver/biliary system phenotype	MP:0005370	11.1	SEPP1, VEGFA, BMP4, XBP1, ATF6, ATF4
10	normal phenotype	MP:0002873	9.8	SELE, VEGFA, VCAN, MYC, MYCL1, BMP4
11	tumorigenesis	MP:0002006	9.4	SFTPC, SERPINE1, MYC, SDC1, SCGB1A1, MUC1
12	adipose tissue phenotype	MP:0005375	9.4	SERPINE1, MYC, ATF4, CD36, MECP2, IL18
13	digestive/alimentary phenotype	MP:0005381	9.4	RETNLB, VWF, VEGFA, MYC, BMP4, LGALS3
14	growth/size phenotype	MP:0005378	9.0	SFTPC, SFTPD, SELE, SETD2, SEPP1, SERPINE1
15	nervous system phenotype	MP:0003631	8.9	VWF, SEMA7A, VCAN, MYC, BMP4, BLOC1S6
16	other phenotype	MP:0005395	8.8	BLOC1S6, KDR, LAMC2, CDKN2A, FN1, IL13
17	embryogenesis phenotype	MP:0005380	8.6	SETD2, VIM, MYC, XBP1, CFLAR, FZD1
18	skeleton phenotype	MP:0005390	8.4	VEGFA, VCAN, MYC, BMP4, BMP6, BLOC1S6
19	hematopoietic system phenotype	MP:0005397	INF	SERPINB1, BMP4, BLOC1S6, LGALS3, XBP1, CFLAR
20	vision/eye phenotype	MP:0005391	INF	SFTPC, SELE, VIM, VEGFA, BMP4,
21	reproductive system phenotype	MP:0005389	INF	SFTPC, SEPP1, VEGFA, ATF4, FZD1, MMP9
22	behavior/neurological phenotype	MP:0005386	INF	SFTPB, SFTPC, SELE, SEPP1, VIM, BMP4
23	respiratory system phenotype	MP:0005388	INF	SFTPC, SFTPD, SERPINB1, BLOC1S6, SCGB1A1, GSN
24	renal/urinary system phenotype	MP:0005367	INF	BMP4, BLOC1S6, SCGB1A1, LAMC2, CD63, GREM1
25	cardiovascular system phenotype	MP:0005385	INF	VWF, SFTPC, SELE, SETD2, SERPINE1, VIM
26	integument phenotype	MP:0010771	INF	MYC, BLMH, , BLOC1S6, SDC1, MUC1
27	immune system phenotype	MP:0005387	INF	RETNLB, VWF, SERPINB1, VIM, BSG, BLMH
28	muscle phenotype	MP:0005369	INF	VIM, VEGFA, MYC, BMP4, BLOC1S6, KDR
29	pigmentation phenotype	MP:0001186	INF	MYC, , BLOC1S6, CDKN2A, ILK,

Articles related to pulmonary fibrosis:

(show top 50)    (show all 399)

id	Title	Authors	Year	Affiliating Genes
1	Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. (21436073)	Parry E.M.... Armanios M.	2011	TERT
2	Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. (21871427)	Yamashita C.M.... Downey G.P.	2011	MMP3
3	Telomere lengths, pulmonary fibrosis and telomerase ( TERT) mutations. (20502709)	Diaz de Leon A.... Garcia C.K.	2010	TERT
4	Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic. (19717811)	Ross B.... Giaid A.	2010	EDN1
5	Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. (19597127)	LeppAoranta O.... MyllAorniemi M.	2010	GATA6
6	Inhibition of PI3K by PX-866 prevents transforming gr owth factor-alpha-induced pulmonary fibrosis. (20042669)	Le Cras T.D.... Hardie W.D.	2010	EGFR, TGFA
7	Surfactant protein-D predicts survival in patients wi th idiopathic pulmonary fibrosis. (20560296)	Barlo N.P.... Grutters J.C.	2009	SFTPD
8	Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. (19060230)	Mercer P.F.... Chambers R.C.	2009	CCL2, F2R
9	Different activity of the biological axis VEGF-Flt-1 (fms-like tyrosine kinase 1) and CXC chemokines between pulmonary sarcoidosis a nd idiopathic pulmonary fibrosis: a bronchoalveolar lavage study. (20169144)	Antoniou K.M.... Siafakas N.M.	2009	FLT1, CXCR4, VEGFA
10	Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis. (19565553)	Fertig N.... Feghali-Bostwick C.A.	2009	SNRNP35
11	WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. (19287097)	KAPnigshoff M.... Eickelberg O.	2009	WISP1
12	Angiotensinogen gene G-6A polymorphism influences Idiopathic Pulmonary Fibrosis disease progression. (18508830)	Molina-Molina M.... Uhal B.D.	2008	AGT
13	Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. (17975199)	Myllarniemi M.... Koli K.	2008	TGFB1, GREM1
14	Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways. (18467708)	Hsu E.... Feghali-Bostwick C.A.	2008	IGF2
15	Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis. (18236067)	Yamada M.... Kasper M.	2008	AQP5
16	Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. (18187693)	McMillan T.R.... Toews G.B.	2008	CCL2
17	A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. (18835860)	Mushiroda T.... Nakamura Y.	2008	TERT
18	Role of galectin-3 in human pulmonary fibrosis. (17259811)	Nishi Y.... Shirai K.	2007	LGALS3
19	Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. (17274978)	Higashiyama H.... Kinoshita M.	2007	TGFBR1, CD36, CTGF
20	Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. (17207287)	Wu Z.... Xu J.	2007	MYH11
21	STAT1 antisense oligonucleotides inhibit secretion of TNF-alpha, IL-8 and NO in alveolar macrophages of rats suffering from interstitial pulmonary fibrosis (16806015)	Fan X.M.... Wang Z.L.	2006	IL8
22	A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. (16415274)	Prasse A.... Zissel G.	2006	CCL18
23	The polymorphism C5507G of complement receptor 1 does not explain idiopathic pulmonary fibrosis among the Finns. (15733500)	Hodgson U.... Laitinen T.	2005	CR1
24	Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (16085216)	Nakayama S.... Kohno S.	2005	CXCR3, CXCL5
25	Cultured alveolar macrophages from patients with idiopathic pulmonary fibrosis (IPF) show dysregulation of lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) inductions. (15809201)	Freeburn R.W.... Millar A.B.	2005	IL10RA
26	Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis. (15170923)	Yanaba K.... Sato S.	2004	SFTPD
27	Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. (15308504)	Kitasato Y.... Aizawa H.	2004	IL18
28	Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)	Lappi-Blanco E.... Paakko P.	2004	LAMC2
29	Transforming growth factor-beta1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis. (12746254)	Xaubet A.... Picado C.	2003	TGFB1
30	Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice. (14575803)	Tomimori Y.... Fukuda Y.	2003	TGFB1, CMA1
31	Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. (13680361)	Selman M.... Floros J.	2003	SFTPD, SFTPA1, SFTPB
32	A dark side of interferon-gamma in the treatment of idiopathic pulmonary fibrosis? (12663333)	Selman M.	2003	IFNG
33	Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis. (12771616)	Azoulay E.... Delclaux C.	2003	MPO, CSF3
34	Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis. (12947024)	Marchand-Adam S.... Crestani B.	2003	HGF, IL6
35	Clinical characterization of interleukin-8 in patients with idiopathic pulmonary fibrosis (12645107)	Totani Y.... Ishizaki T.	2002	IL8
36	Serum surfactant proteins-A and -D as biomarkers in idiopathic pulmonary fibrosis. (11936520)	Greene K.E.... Mason R.J.	2002	SFTPD
37	Role of oxidative stress in pulmonary fibrosis. (12619377)	Mastruzzo C.... Vancheri C.	2002	JUN
38	Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study. (12373774)	Magi B.... Rottoli P.	2002	PRDX1
39	Circulating cytokeratin 8:anti-cytokeratin 8 antibody immune complexes in sera of patients with pulmonary fibrosis. (10940793)	Dobashi N.... Takahara J.	2000	KRT8
40	Levels of cytokeratin 19 fragments in bronchoalveolar lavage fluid correlate to the intensity of neutrophil and eosinophil-alveolitis in patients with idiopathic pulmonary fibrosis. (10714422)	Inage M.... Tomoike H.	2000	KRT19
41	Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary fibrosis. (10871435)	Dobashi N.... Takahara J.	2000	KRT18
42	The number of interleukin 1 receptors on lung fibroblasts in patients with idiopathic pulmonary fibrosis. (10364740)	Takeuchi M.... Izumi T.	1999	IL1R1, IL1RAPL2
43	The role of eosinophils in pulmonary fibrosis (Review ). (9852197)	Gharaee-Kermani M.... Phan S.H.	1998	CCL3, TGIF1
44	The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. (9233641)	Keane M.P.... Strieter R.M.	1997	IL8, CXCL10
45	Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. (7542280)	Miyazaki Y.... Vassalli P.	1995	TNF
46	Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. (8325116)	Kline J.N.... Hunninghake G.W.	1993	IL1B, IL1R1
47	Elevated serum superoxide dismutase levels correlate with disease severity and neutrophil degranulation in idiopathic pulmonary fibrosis. (8403808)	BorzA- R.M.... Facchini A.	1993	SOD1, ELANE
48	TNF in autoimmune diseases, graft-versus-host reactions, and pulmonary fibrosis. (1550870)	Vassalli P.... Piguet P.F.	1992	TNF
49	Administration of alpha 1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters. (1372163)	Nagai A.... Takizawa T.	1992	ELANE
50	Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. (2156165)	Piguet P.F.... Vassalli P.	1990	FGF2

Genes related to pulmonary fibrosis according to GeneCards:

(show top 50)    (show all 288)

id	Symbol	Description	Score	GeneCards Section Context
1	SFTPA1	surfactant protein A1	11.1	Summaries, Publications
2	SFTPA2	surfactant protein A2	11.1	Summaries, Publications
3	ELMOD2	ELMO/CED-12 domain containing 2	11.1	Publications, Summaries
4	TERC	telomerase RNA component	11.0	Publications
5	TERT	telomerase reverse transcriptase	11.0	Publications
6	SFTPC	surfactant protein C	11.0	Publications
7	GRP	gastrin-releasing peptide	11.0	Publications
8	SFTPD	surfactant protein D	11.0	Publications
9	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
10	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
11	SOD3	superoxide dismutase 3, extracellular	11.0	Publications
12	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
13	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications
14	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
15	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
16	CTGF	connective tissue growth factor	11.0	Publications
17	DDR1	discoidin domain receptor tyrosine kinase 1	11.0	Publications
18	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
19	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
20	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
21	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
22	ELANE	elastase, neutrophil expressed	11.0	Publications
23	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
24	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
25	BMP6	bone morphogenetic protein 6	11.0	Publications
26	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
27	EDN1	endothelin 1	11.0	Publications
28	MPO	myeloperoxidase	11.0	Publications
29	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
30	SMAD3	SMAD family member 3	11.0	Publications
31	CAV1	caveolin 1, caveolae protein, 22kDa	11.0	Publications
32	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
33	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
34	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
35	IL13	interleukin 13	11.0	Publications
36	TGFA	transforming growth factor, alpha	11.0	Publications
37	TGFB1	transforming growth factor, beta 1	11.0	Publications
38	PLAU	plasminogen activator, urokinase	11.0	Publications
39	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
40	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
41	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
42	IL1B	interleukin 1, beta	11.0	Publications
43	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
44	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
45	IL8	interleukin 8	11.0	Publications
46	SOD1	superoxide dismutase 1, soluble	11.0	Publications
47	DKK4	dickkopf homolog 4 (Xenopus laevis)	11.0	Publications
48	SRXN1	sulfiredoxin 1	11.0	Publications
49	PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	11.0	Publications
50	LOC152586	glycosyltransferase 54 domain-containing protein	11.0	Publications

Pathways related to pulmonary fibrosis according to GeneDecks:

(show top 50)    (show all 191)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	12.1	BMP4, ATF4, CD28, FGF7, IL10, IL10RA
2	Cytokine-cytokine receptor interaction20	11.3	VEGFA, KDR, FLT1, IL10, IL10RA, IL11
3	p38 Signaling36	11.3	BMP4, BMP6, KDR, CD28, FLT1, FGF2
4	Actin-Based Motility by Rho Family GTPases36	11.3	BMP4, GSN, FGF7, IL2, IGF1, CTGF
5	Glioma Invasiveness36	11.2	BMP4, BMP6, FGF2, FGF7, IL3, F2R
6	Transendothelial Migration of Leukocytes36	11.2	NCF1, NCF2, SDC1, LAMC2, MMP1, MMP2
7	all-trans-Retinoic Acid Signaling in Brain36	11.2	BMP4, BMP6, IL10, IL11, IL12A, IL12B
8	MAPK Family Pathway36	11.2	BMP4, BMP6, KDR, ATF4, JUN, FLT1
9	PAK Pathway36	11.1	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
10	mTOR Pathway36	11.0	BMP4, BMP6, FGF2, FGF7, IL2, IL3
11	ERK Signaling36	11.0	MYC, BMP4, BMP6, LAMC2, ATF4, FN1
12	TGF-Beta Pathway36	11.0	BMP4, BMP6, KDR, JUN, FOS, FLT1
13	Tec Kinases Signaling36	11.0	BMP4, BMP6, CD28, FOS, FGF2, FGF7
14	Influenza A20	11.0	JUN, IL12A, IL12B, IL18, IL1A, IL1B
15	MIF Mediated Glucocorticoid Regulation36	10.9	BMP4, BMP6, MIF, IL10, IL11, IL12A
16	Rac1 Pathway36	10.9	NCF2, BMP4, BMP6, KDR, JUN, FGF2
17	Glucocorticoid Receptor Signaling36	10.9	BMP4, BMP6, ATF4, JUN, FOS, GTF2H2
18	DHA Signaling36	10.9	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
19	NF-KappaB (p50-p65) Pathway36	10.8	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
20	eNOS Signaling36	10.8	BMP6, FGF7, IL2, IL3, AQP5, CCNA2
21	IL-6 Pathway36	10.8	BMP4, BMP6, IL10, IL11, IL12A, IL12B
22	Antioxidant Action of Vitamin-C36	10.7	NCF1, NCF2, BMP4, BMP6, KDR, JUN
23	Nuclear Receptor Activation by Vitamin-A36	10.7	BMP4, BMP6, KDR, ATF4, FLT1, GTF2H2
24	NF-KappaB Family Pathway36	10.7	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
25	14-3-3 Induced Intracellular Signaling36	10.6	BMP4, JUN, FLT1, FGF2, FGF7, IL3
26	Mitochondrial Apoptosis36	10.6	BMP4, BMP6, KDR, CDKN2A, FLT1, FGF2
27	eIF2 Pathway36	10.6	BMP4, BMP6, FGF2, FGF7, IL2, IL2RA
28	MIF Regulation of Innate Immune Cells36	10.5	BMP4, BMP6, JUN, FOS, MIF, IL10
29	CREB Pathway36	10.5	BMP4, BMP6, KDR, ATF4, FGF7, IL2
30	Activation of PKC through GPCR36	10.5	BMP4, BMP6, KDR, ATF4, FLT1, FGF2
31	Pancreatic Adenocarcinoma36	10.5	BMP4, BMP6, KDR, CDKN2A, MMP1, MMP2
32	Jak-STAT signaling pathway20	10.4	MYC, IL10, IL10RA, IL11, IL12A, IL12B
33	MAPK Signaling36	10.4	MYC, BMP4, BMP6, KDR, LAMC2, ATF6
34	p53 Mediated Apoptosis36	10.4	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
35	Chagas disease (American trypanosomiasis)20	10.4	SERPINE1, CFLAR, JUN, FOS, IL10, IL12A
36	Nanog in Mammalian ESC Pluripotency36	10.3	BMP4, BMP6, KDR, FZD1, FLT1, FGF2
37	Endothelin-1 Signaling Pathway36	10.3	MYC, BMP4, BMP6, FLT1, IL10, IL11
38	Estrogen Pathway36	10.3	BMP4, BMP6, KDR, ATF4, JUN, FOS
39	Colorectal Cancer Metastasis36	10.2	MYC, FZD1, MMP1, MMP2, MMP7, MMP9
40	p70S6K Signaling36	10.2	BMP4, BMP6, KDR, FLT1, FGF2, FGF7
41	Phospholipase-C Pathway36	10.2	BMP4, BMP6, KDR, LAMC2, ATF4, FN1
42	NFAT in Immune Response36	10.1	BMP4, BMP6, KDR, JUN, CD28, FOS
43	GPCR Pathway36	10.1	BMP4, BMP6, KDR, ATF4, JUN, FOS
44	Rheumatoid arthritis20	10.0	VEGFA, JUN, CD28, MMP1, MMP3, FOS
45	Leishmaniasis20	9.9	NCF1, NCF2, JUN, FOS, FCGR2A, FCGR3B
46	Molecular Mechanisms of Cancer36	9.9	MYC, BMP4, BMP6, KDR, CFLAR, FZD1
47	Immune response IL-1 signaling pathway10	9.9	SERPINE1, JUN, FOS, FOSL2, IL1A, IL1B
48	Hematopoietic cell lineage20	9.5	CD36, IL11, IL1A, IL1B, IL1R1, IL2RA
49	Pathways in cancer20	9.4	VEGFA, MYC, BMP4, FZD1, JUN, MMP1
50	Telomerase Components in Cell Signaling36	INF	MYC, BMP4, BMP6, KDR, FLT1, FGF2

Compounds related to pulmonary fibrosis according to GeneDecks:

(show top 50)    (show all 432)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	15.3	NCF2, VWF, SFTPA1, SFTPA2, SFTPB, SFTPC
2	ribonucleic acid32	11.9	SFTPB, SFTPC, MYC, BMP4, BMP6, MUC1
3	atorvastatin32 34 9 18 9	15.4	VWF, SELE, VEGFA, BMP6, MMP1, MMP2
4	nifedipine32 9 9	13.4	SELE, SERPINE1, BMP6, MMP9, GRP, IL1A
5	glucose32	11.3	SETD2, SEPP1, LPO, VCAN, CLEC12A, XBP1
6	pge232	11.2	SFTPB, SELE, SETD2, BMP4, MMP1, MMP3
7	nitric oxide32 9 18 9	14.1	NCF2, SFTPB, SFTPD, SELE, SERPINA1, LPO
8	simvastatin32 34 42 9 18 9	16.0	VWF, SELE, SERPINE1, VEGFA, BMP6, KDR
9	lipoteichoic acid32	11.0	SELE, IL10, IL12B, IL18, IL1B, IL1R1
10	retinoic acid32 42 18	13.0	NCF2, VWF, SFTPB, SFTPC, SETD2, SERPINE1
11	rosiglitazone32 9 18 9	14.0	SELE, SERPINE1, JUN, CD36, MMP1, MMP2
12	dihydrotestosterone32 9 18 9	13.9	SETD2, SERPINE1, VIM, BMP6, GSN, FGF2
13	nicotine32 34 9 9	13.9	GRP, ANXA1, CCR7
14	glycosaminoglycan32	10.9	VCAN, CD36, MMP16, FGF2, FGF7, IL1RAPL2
15	latex32	10.8	VWF, SCGB1A1, LGALS3, FN1, GSN, FGF7
16	nadph32 18	11.8	NCF1, LPO, FCGR3B, AKT1, CYCS, NOX4
17	rottlerin32 42	11.7	JUN, CD36, GRP, IL6R, IL8, MAPK8
18	fmlp32	10.7	NCF2, VIM, S100A9, MPO, FN1, GSN
19	tgf beta132	10.7	SETD2, SERPINE1, VCAN, BMP6, KDR, CD36
20	groalpha32	10.7	SELE, IL10, IL13, IL18, IL1A, IL1B
21	infliximab32 9 9	12.7	SELE, VEGFA, MMP1, MMP3, FGF2, IL10
22	matrigel32	10.6	VWF, SELE, SERPINE1, VIM, BSG, VEGFA
23	superoxide32 18	11.6	NCF2, SETD2, SERPINB1, LPO, LGALS3, MPO
24	estradiol32 9 18 9	13.6	SERPINE1, VIM, LPO, MUC1, CFLAR, IL11
25	azathioprine32 34 9 9	13.6	VIM, BMP4, CDKN2A, MMP2, GSN, MECP2
26	thapsigargin32 42	11.6	SERPINE1, XBP1, ATF6, ATF4, CD36, CDKN3
27	c2ceramide32	10.6	JUN, IL1B, MAPK8, MAPK14, AKT1, TNF
28	hydrocortisone32 9 9	12.6	VIM, BMP6, KDR, MUC1, CD36, MMP1
29	rantes32	10.6	SELE, BMP6, JUN, CD63, MMP1, MMP3
30	bleomycin32 9 9	12.5	SFTPB, SFTPC, BLMH, CDKN3, FGF2, FGF7
31	indomethacin32 9 9	12.5	VIM, MYC, BMP6, KDR, MPO, CDKN3
32	budesonide32 42 9 9	13.4	SFTPD, CD36, ANXA1, CCL11, PTGS1, RNASE3
33	estrogen32	10.4	VWF, SETD2, SERPINA1, SERPINE1, BSG, BMP4
34	agar32	10.4	VIM, MUC1, CDKN2A, FN1, FHIT, FGF2
35	paraffin32	10.4	VWF, SFTPB, SERPINA1, VIM, VEGFA, MYC
36	tetracycline32 9 9	12.3	VWF, SFTPC, SCGB1A1, CDKN2A, MMP1, MMP2
37	sodium arsenite32	10.3	MYC, CFLAR, JUN, FGF7, IL1A, IL2RA
38	lipid32	10.3	SFTPB, SFTPC, SFTPD, SELE, SETD2, SERPINA1
39	polyethylene glycol32	10.3	SELE, MUC1, MPO, FN1, IGF2, HMOX1
40	phosphotyrosine32	10.1	KDR, CD28, CDKN3, FOS, FN1, IL2RB
41	ivig32	10.0	VWF, IL1RAPL2, IL3, CCL4, CCR5, CRP
42	lactate32	9.9	VWF, SFTPD, SELE, SETD2, VIM, BSG
43	calcitriol32 42 9 18 9	13.9	MYC, BMP6, S100A9, JUN, CD36, FOS
44	ionomycin32	9.8	SETD2, FOS, GSN, GRP, IL3, IL5
45	carboplatin32 34 9 9	12.8	VEGFA, KDR, IL11, IL1A, IL3, IFNG
46	celecoxib32 42 34 9 18 9	14.7	VEGFA, KDR, ATF4, MMP1, MMP2, MMP3
47	5-aza-2deoxycytidine32	9.7	VIM, MYC, BMP6, CFLAR, CDKN2A, FHIT
48	pd 98,05932	9.7	SETD2, SERPINE1, MYC, BMP4, BMP6, CFLAR
49	butyrate32	9.2	NCF2, SETD2, VIM, MYC, BMP6, LGALS3
50	genistein32 9 18 9	12.0	SELE, SETD2, SERPINE1, VIM, VEGFA, MYC

Cellular components related to pulmonary fibrosis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	NOTCH4, NOS2, NOD2, SMAD3, SMAD2, PPARG
2	cytoplasm	GO:005737	INF	SPINT2, CTNNB1, SMAD2, SMAD3, NOD2, NOS2
3	extracellular space	GO:005615	11.6	TPT1, CCL4, ANXA1, APCS, IL8, IL7
4	external side of plasma membrane	GO:009897	11.2	ECE1, ROBO4, CXCR4, CXCR3, CXCL9, CXCL10
5	platelet alpha granule lumen	GO:031093	11.0	HGF, TGFB1, TIMP1, PDGFB, PDGFA, SPARC
6	proteinaceous extracellular matrix	GO:005578	10.9	ADAMTSL1, VCAN, VEGFA, SERPINA1, VWF, BMP4
7	extracellular region	GO:005576	10.8	TLR9, AGT, AGER, HBEGF, ELANE, EDN1
8	cell surface	GO:009986	10.8	CD36, FZD1, VEGFA, CD63, PDGFB, PDGFA
9	integral to plasma membrane	GO:005887	10.6	NTRK2, SSTR2, CYSLTR1, DDR1, TNFSF12, TNF
10	extracellular matrix	GO:031012	10.1	COL1A1, COL18A1, LTBP1, TIMP3, SOD1, SOD3
11	plasma membrane	GO:005886	9.8	CTNNB1, SMAD3, CR1, PLAU, NOD2, NOTCH4
12	protein complex	GO:043234	9.6	ANXA1, ALB, CAV1, TP53, PTGS2, TOP2A

Biological processes related to pulmonary fibrosis according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:007596	INF	VWF, SERPINA1, SERPINE1, BSG, VEGFA, BLOC1S6
2	cell-cell signaling	GO:007267	11.9	S100A9, FZD1, GREM1, IL10, IL11, IL13
3	signal transduction	GO:007165	11.6	SCGB1A1, S100A9, ATF6, MPP1, FGF2, FGF7
4	immune response	GO:006955	11.5	SEMA7A, BMP6, XBP1, FCGR3B, IL12A, IL13
5	response to lipopolysaccharide	GO:032496	11.5	NCF2, SFTPB, SFTPC, SELE, SERPINA1, S100A9
6	chemotaxis	GO:006935	11.5	S100A9, FGF2, IL4, MAPK14, MAPK1, CCL4
7	inflammatory response	GO:006954	11.4	SELE, SEMA7A, BMP6, S100A9, FOS, MIF
8	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.4	SEMA7A, BMP4, KDR, MIF, FGF2, IL1A
9	response to hypoxia	GO:001666	11.3	SFTPB, SERPINA1, VEGFA, MMP9, FLT1, MECP2
10	respiratory gaseous exchange	GO:007585	11.1	SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, MECP2
11	response to glucocorticoid stimulus	GO:051384	11.1	SFTPB, SFTPC, SERPINE1, IL10, IL1B, IL1RN
12	anti-apoptosis	GO:006916	11.1	MUC1, CFLAR, MPO, IL10, IL1A, IL1B
13	response to organic cyclic compound	GO:014070	11.0	NCF2, SERPINA1, BMP4, JUN, IL1A, IL1RN
14	positive regulation of smooth muscle cell proliferation	GO:048661	11.0	BMP4, JUN, FLT1, IL13, IL6, IL6R
15	positive regulation of mitosis	GO:045840	11.0	CD28, IL1A, IL1B, IGF2, IGF1, TNF
16	response to hyperoxia	GO:055093	10.9	NCF2, SFTPB, SFTPC, SERPINE1, MMP9, IL18
17	positive regulation of angiogenesis	GO:045766	10.9	SERPINE1, VEGFA, KDR, MMP9, FLT1, FGF2
18	positive regulation of inflammatory response	GO:050729	10.9	SERPINE1, IL12B, IL18, IL1RL1, IL2, CCL3
19	positive regulation of MAPK cascade	GO:043410	10.9	KDR, CD36, FLT1, IL11, IL6, IL6R
20	aging	GO:007568	10.8	NCF2, MSRA, JUN, GSN, IL1B, CCL2
21	monocyte chemotaxis	GO:002548	10.8	FLT1, IL6, IL6R, CCL7, CCL2, CCL3
22	platelet degranulation	GO:002576	10.8	VWF, SERPINA1, SERPINE1, VEGFA, CD36, CD63
23	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.7	VEGFA, CD36, MIF, FGF7, IL11, IL3
24	cellular response to organic cyclic compound	GO:071407	10.7	IL18, IL1B, CCL2, CCL3, CCL5, IGFBP5
25	response to wounding	GO:009611	10.7	VWF, FN1, FGF7, F2, F2R, TNC
26	positive regulation of MAP kinase activity	GO:043406	10.6	VEGFA, FLT1, ILK, TNF, NOX4, PDE5A
27	positive regulation of cell migration	GO:030335	10.6	VEGFA, KDR, FLT1, ILK, CCL7, CCL11
28	positive regulation of nitric oxide biosynthetic process	GO:045429	10.6	IL1B, IFNG, ICAM1, AKT1, TNF, PTGS2
29	angiogenesis	GO:001525	10.6	SETD2, SERPINE1, VEGFA, KDR, JUN, MMP2
30	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.6	KDR, FLT1, CCL5, IGF1, F2, F2R
31	positive regulation of protein phosphorylation	GO:001934	10.6	VEGFA, BMP4, FZD1, IL1B, CCND1, IGF2
32	cellular response to mechanical stimulus	GO:071260	10.6	SFTPB, SFTPC, IL13, IL18, IL1B, MAPK8
33	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.5	CD36, MAPK14, F2, TP53, NFE2L2, PDGFB
34	positive regulation of apoptotic process	GO:043065	10.5	BMP4, MMP9, ING4, IL1B, ANXA1, GPLD1
35	cellular response to lipopolysaccharide	GO:071222	10.5	SERPINE1, CD36, ARG1, IL10, IL12B, IL8
36	MAPK cascade	GO:000165	10.4	MYC, IL18, IL1B, MAPK1, CCL2, CCR5
37	apoptotic process	GO:006915	10.4	VIM, CFLAR, ING4, GSN, FGF2, GREM1
38	cell surface receptor signaling pathway	GO:007166	10.4	BSG, CD28, CD36, MIF, IL1R1, IL2RA
39	positive regulation of protein kinase B signaling cascade	GO:051897	10.3	ILK, CCL3, CCL21, CCR7, IGFBP5, IGF2
40	response to cytokine stimulus	GO:034097	10.3	SERPINA1, SERPINE1, JUN, IL4, IL6R, IL6ST
41	innate immune response	GO:045087	10.3	NCF1, NCF2, SFTPD, LGALS3, JUN, FOS
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.2	SERPINE1, VEGFA, MYC, BMP4, BMP6, ATF4
43	positive regulation of endothelial cell proliferation	GO:001938	10.1	VEGFA, BMP4, BMP6, KDR, JUN, ARG1
44	positive regulation of fibroblast proliferation	GO:048146	10.1	MYC, JUN, FOSL2, MIF, IGF1, PDGFA
45	negative regulation of cell proliferation	GO:008285	10.0	BMP4, JUN, CDKN2A, CDKN3, ING4, FGF2
46	negative regulation of apoptotic process	GO:043066	9.8	SERPINE1, VEGFA, MYC, BMP4, KDR, MIF
47	positive regulation of transcription, DNA-dependent	GO:045893	9.5	MYC, BMP4, ATF4, FZD1, JUN, CDKN2A
48	positive regulation of cell proliferation	GO:008284	9.0	VEGFA, MYC, KDR, FLT1, FGF2, FGF7
49	response to drug	GO:042493	INF	NCF2, MYC, , XBP1, FZD1, JUN
50	platelet activation	GO:030168	INF	VWF, SERPINA1, SERPINE1, VEGFA, , CD36

Molecular functions related to pulmonary fibrosis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.2	CXCL9, IL8, CXCL5, CXCL11, CXCL10, CCL5
2	heparin binding	GO:008201	10.4	CCL5, CTGF, ELANE, HBEGF, SOD3, SLIT2
3	cytokine activity	GO:005125	10.4	IL6, BMP6, BMP4, VEGFA, MIF, FGF2
4	chemoattractant activity	GO:042056	10.1	HMGB1, CCL5, CCL3, FGF7, FGF2, MIF
5	growth factor activity	GO:008083	9.6	CSF3, CSF2, CSF1, DKK1, TGFB1, TGFA
6	enzyme binding	GO:019899	9.6	CTNNBL1, PPARG, NOD2, EGFR, TOP2A, TGFB1
7	protein homodimerization activity	GO:042803	8.8	PDGFA, NFKB1, NOS2, CRP, SMAD3, NTRK2
8	protein binding	GO:005515	INF	GATA6, GABPA, EPO, HGF, EHMT2, WNT3A