MCID: PLM044
MIFTS: 27

Pulmonary Fibrosis, Familial malady

Genetic diseases (common), Respiratory diseases categories

Summaries for Pulmonary Fibrosis, Familial

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20GeneReviews, 34MalaCards
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MalaCards: Pulmonary Fibrosis, Familial, also known as adult familial cryptogenic fibrosing alveolitis, is related to pulmonary fibrosis and idiopathic pulmonary fibrosis. An important gene associated with Pulmonary Fibrosis, Familial is TERT (telomerase reverse transcriptase), and among its related pathways are Phagosome and Pertussis. The compounds lipofectamine and tin(2+) have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

GeneReviews summary for pf

Aliases & Classifications for Pulmonary Fibrosis, Familial

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20GeneReviews, 21GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary fibrosis, familial 20 21
adult familial cryptogenic fibrosing alveolitis 20
familial interstitial pneumonia 20


Related Diseases for Pulmonary Fibrosis, Familial

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Pulmonary Fibrosis, Familial:



Diseases related to pulmonary fibrosis, familial

Symptoms for Pulmonary Fibrosis, Familial

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Drugs & Therapeutics for Pulmonary Fibrosis, Familial

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pulmonary Fibrosis, Familial

Drug clinical trials:

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Genetic Tests for Pulmonary Fibrosis, Familial

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21GeneTests
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Genetic tests related to Pulmonary Fibrosis, Familial:

id Genetic test Affiliating Genes
1 Familial Pulmonary Fibrosis21 TERT

Anatomical Context for Pulmonary Fibrosis, Familial

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Animal Models for Pulmonary Fibrosis, Familial or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pulmonary Fibrosis, Familial:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6SFTPC, TERC, TERT

Publications for Pulmonary Fibrosis, Familial

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53PubMed
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Articles related to Pulmonary Fibrosis, Familial:

idTitleAuthorsYear
1
Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. (21613931)
2011
2
Pulmonary Fibrosis, Familial (20301408)
1993

Variations for Pulmonary Fibrosis, Familial

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Expression for genes affiliated with Pulmonary Fibrosis, Familial

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Fibrosis, Familial

Search GEO for disease gene expression data for Pulmonary Fibrosis, Familial.

Pathways for genes affiliated with Pulmonary Fibrosis, Familial

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SFTPA2, SFTPA1
29.5SFTPA2, SFTPA1
3
Show member pathways
FOXA transcription factor networks39
9.5SFTPA2, SFTPA1

Compounds for genes affiliated with Pulmonary Fibrosis, Familial

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipofectamine469.6TERC, TERT
2tin(2+)469.6TERC, TERT
3zidovudine46 52 1211.6TERT, TERC
4adpribose469.5TERC, TERT
55fluorouracil469.4TERC, TERT
6adriamycin469.3TERC, TERT
7retinoic acid46 259.3SFTPC, TERC, TERT
8calcium46 52 25 1211.3TERT, SFTPA1, SFTPC, SFTPA2

GO Terms for genes affiliated with Pulmonary Fibrosis, Familial

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Sources:
17Gene Ontology
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Cellular components related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.2SFTPA2, SFTPA1
2extracellular spaceGO:0056158.7SFTPA2, SFTPC, SFTPA1

Biological processes related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075858.7SFTPA2, SFTPC, SFTPA1

Molecular functions related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.5SFTPA2, SFTPA1

Products for genes affiliated with Pulmonary Fibrosis, Familial

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Fibrosis, Familial

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet