MCID: PLM044
MIFTS: 27

Pulmonary Fibrosis, Familial malady

Genetic diseases (common), Respiratory diseases categories
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Summaries for Pulmonary Fibrosis, Familial

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MalaCards based summary: Pulmonary Fibrosis, Familial, also known as adult familial cryptogenic fibrosing alveolitis, is related to pulmonary fibrosis and idiopathic pulmonary fibrosis. An important gene associated with Pulmonary Fibrosis, Familial is TERT (telomerase reverse transcriptase), and among its related pathways are Phagosome and Pertussis. The compounds lipofectamine and tin(2+) have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

GeneReviews summary for pf

Aliases & Classifications for Pulmonary Fibrosis, Familial

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Pulmonary Fibrosis, Familial, Aliases & Descriptions:

Name: Pulmonary Fibrosis, Familial 19 20
Adult Familial Cryptogenic Fibrosing Alveolitis 19
 
Familial Interstitial Pneumonia 19


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Related Diseases for Pulmonary Fibrosis, Familial

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Graphical network of the top 20 diseases related to Pulmonary Fibrosis, Familial:



Diseases related to pulmonary fibrosis, familial

Symptoms for Pulmonary Fibrosis, Familial

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Drugs & Therapeutics for Pulmonary Fibrosis, Familial

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Fibrosis, Familial

Search NIH Clinical Center for Pulmonary Fibrosis, Familial

Genetic Tests for Pulmonary Fibrosis, Familial

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Genetic tests related to Pulmonary Fibrosis, Familial:

id Genetic test Affiliating Genes
1 Familial Pulmonary Fibrosis20 TERT

Anatomical Context for Pulmonary Fibrosis, Familial

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Animal Models for Pulmonary Fibrosis, Familial or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Fibrosis, Familial:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6SFTPC, TERC, TERT

Publications for Pulmonary Fibrosis, Familial

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Articles related to Pulmonary Fibrosis, Familial:

idTitleAuthorsYear
1
Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. (21613931)
2011
2
Pulmonary Fibrosis, Familial (20301408)
1993

Variations for Pulmonary Fibrosis, Familial

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Expression for genes affiliated with Pulmonary Fibrosis, Familial

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Expression patterns in normal tissues for genes affiliated with Pulmonary Fibrosis, Familial

Search GEO for disease gene expression data for Pulmonary Fibrosis, Familial.

Pathways for genes affiliated with Pulmonary Fibrosis, Familial

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Pathways related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SFTPA2, SFTPA1
29.5SFTPA2, SFTPA1
3
Show member pathways
FOXA transcription factor networks37
9.5SFTPA2, SFTPA1

Compounds for genes affiliated with Pulmonary Fibrosis, Familial

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipofectamine449.6TERC, TERT
2tin(2+)449.6TERC, TERT
3zidovudine44 50 1111.6TERT, TERC
4adpribose449.5TERC, TERT
55fluorouracil449.4TERC, TERT
6adriamycin449.3TERC, TERT
7retinoic acid44 249.3SFTPC, TERC, TERT
8calcium44 50 24 1111.3TERT, SFTPA1, SFTPC, SFTPA2

GO Terms for genes affiliated with Pulmonary Fibrosis, Familial

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Cellular components related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.2SFTPA2, SFTPA1
2extracellular spaceGO:0056158.7SFTPA2, SFTPC, SFTPA1

Biological processes related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075858.7SFTPA2, SFTPC, SFTPA1

Molecular functions related to Pulmonary Fibrosis, Familial according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.5SFTPA2, SFTPA1

Products for genes affiliated with Pulmonary Fibrosis, Familial

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  • Antibodies
  • Proteins
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Sources for Pulmonary Fibrosis, Familial

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet