Pulmonary Hypertension malady

MedlinePlus: Pulmonary hypertension is high blood pressure in the arteries to your lungs. it is a serious condition for which there are treatments but no cure. if you have it, the blood vessels that carry oxygen-poor blood from your heart to your lungs become hard and narrow. your heart has to work harder to pump the blood through. over time, your heart weakens and cannot do its job and you can develop heart failure. there are two main kinds of pulmonary hypertension. one runs in families or appears for no known reason. the other kind is related to another condition, usually heart or lung disease. treating pulmonary hypertension involves treating the heart or lung disease, medicines, oxygen and sometimes lung transplantation. nih: national heart, lung, and blood institute²³

MalaCards: Pulmonary Hypertension, also known as pulmonary hypertension (disorder), is related to primary pulmonary hypertension and hypertension. An important gene associated with Pulmonary Hypertension is BMPR2 (bone morphogenetic protein receptor, type II (serine/threonine kinase)), and among its related pathways are Akt Signaling and JNK Pathway. The drugs bendroflumethiazide and diltiazem and the compounds nitric oxide and thromboxane have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and immune system.

CDC: Symptoms of pulmonary hypertension include—²

Wikipedia: In medicine, pulmonary hypertension (PH) is an increase of blood pressure in the pulmonary artery,...⁴⁴ more...

Aliases & Descriptions:

pulmonary hypertension 6 7 17 8 23 43 pulmonary hypertension (disorder) 6 hypertension pulmonary 32

hypertensive disease 43

Diseases related to pulmonary hypertension by text searches and GeneDecks gene sharing:

(show top 50)    (show all 964)

id	Related Disease	Score	Top Affiliating Genes
1	primary pulmonary hypertension	44.9	PDE4A, VWF, BZW1, SELP, SERPINE1, BMP2
2	hypertension	41.6	REN, NOS2, NOS3, ACE, AGT, AGTR1
3	thromboembolism	36.6	VWF, SELP, SERPINC1, SERPINE1, MTR, FGA
4	connective tissue disease	33.6	BMP6, BMPR2, CD36, FBN1, APOH, CTGF
5	thrombosis	33.3	FGB, F8, F5, F2, CTEPH1
6	cor pulmonale	33.0	REN, VWF, SERPINC1, FGF2, CAT, EDN1
7	chronic obstructive pulmonary disease	32.7	PDE4A, XDH, MMP9, FGFR1, IL6, IL8
8	congestive heart failure	32.4	PIK3C2A, PDE3B, REN, UTS2, XDH, FN1
9	eisenmenger syndrome	32.0	VWF, BMPR2, EDN1, ACE, THBD, TGFB1
10	interstitial lung disease	31.7	SFTPC, BMP6, GRP, IL1A, IL1R1, IL8
11	systemic lupus erythematosus	31.2	VWF, VIP, CD40LG, FGA, IL10, IL1R1
12	respiratory failure	31.1	PDE4A, CMA1, CCL11, CCL5, ALOX5, CAT
13	sickle cell disease	31.0	PDE3A, VWF, SELP, SERPINE1, VEGFA, BMP4
14	gaucher's disease	30.9	BMP4, CD36, IL1R1, IL6, CCL2, F5
15	congenital diaphragmatic hernia	30.3	SFTPC, ZFPM2, KDR, FGF2, HMOX1, TNF
16	pulmonary embolism	30.2	PIK3C2A, SERPINC1, SERPINE1, FGA, FGB, APOH
17	priapism	30.1	PDE4A, F5, F13A1, HP, NOS2, NOS3
18	hereditary hemorrhagic telangiectasia	30.1	BMP6, BMPR2, ENG, ACVRL1, TGFB1
19	mixed connective tissue disease	30.0	PIK3C2A, BMPR2, CD40LG, IL6, FBN1, APOH
20	hepatopulmonary syndrome	29.7	VWF, RBPJ, SERPINE1, VEGFA, BMPR1A, BMPR2
21	polycythemia	29.5	VWF, SELP, SERPINC1, SERPINE1, VEGFA, BCL2L1
22	malignant hypertension	29.3	REN, VWF, APOH, EDN1, ACE, AGT
23	myelofibrosis	29.2	BMP6, JAK2, FGF2, THPO, EPO
24	thrombophilia	29.1	VWF, SELP, SERPINC1, SERPINE1, JAK2, FGA
25	deep vein thrombosis	29.0	VWF, SELP, SERPINC1, SERPINE1, MTR, FGA
26	hypoxia	29.0	PIK3C2A, PDE4A, REN, RETNLB, VWF, SFTPC
27	hemolytic anemia	28.9	VWF, APOH, F3, HP, G6PD, HBB
28	renovascular hypertension	28.9	REN, ACE, AGTR1, NPPA, ADM
29	patent foramen ovale	28.9	SERPINC1, FGA, APOH, F5, F2, F13A1
30	portal hypertension	28.8	BMPR2, UTS2, HTR2A, F2, ALB, SST
31	high blood pressure	28.7	REN, ALB, NOS3, EDN1, ACE, AGT
32	vascular disease	28.6	SGCB, VWF, SELP, SERPINC1, SERPINE1, VEGFA
33	hernia	28.6	PIK3C2A, ZFPM2, KDR, CD36, MMP9, FGF2
34	poems syndrome	28.3	VEGFA, CD36, IL1B, IL5, IL6, CCL11
35	renal hypertension	28.3	REN, ALB, EDN1, ACE, EPO
36	systemic lupus erythematosus, association with	28.1	SERPINE1, CD40LG, IL10, IL1A, IL6, APOH
37	pre-eclampsia	28.1	REN, VWF, SELP, SERPINC1, SERPINE1, VEGFA
38	pulmonary emphysema	27.8	PCNA, VEGFA, BAX, MMP9, GRP, IL8
39	pulmonary disease	27.8	PDE4A, REN, VWF, SFTPC, PCNA, SELP
40	thrombocytosis	27.8	VWF, SELP, SERPINC1, VEGFA, JAK2, CD40LG
41	emphysema	27.7	SFTPC, PCNA, SERPINE1, VEGFA, BMP6, KDR
42	takayasu's arteritis	27.6	SELP, SERPINC1, CD40LG, MMP9, IL6, APOA1
43	thrombocytopenia	27.4	PIK3C2A, VWF, SELP, SERPINC1, SERPINE1, BMP6
44	copd	27.3	PIK3C2A, PDE4A, VWF, SELP, SERPINE1, VIP
45	pulmonary function	27.3	CD36, IL10, IL5, IL6, IL8, F5
46	hyperuricemia	26.9	PIK3C2A, REN, SELP, SERPINE1, SARS, SARS2
47	primary biliary cirrhosis	26.7	PIK3C2A, PCNA, BMP6, B2M, CD36, CD40LG
48	polymyositis	26.5	PIK3C2A, VWF, VEGFA, IL1A, CCL2, CCL3
49	ventricular septal defect	26.2	VEGFA, ZFPM2, CITED2, NPPA, NPPB, SLC6A4
50	amyloidosis	26.2	VWF, SERPINC1, B2M, CD40LG, MMP9, FGA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [cv490] antihypertensives,other, acebutolol, acebutolol hydrochloride, alprostadil, amiloride, amiloride hydrochloride, amlodipine, amlodipine besylate, atenolol, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bepridil, bepridil hydrochloride, betaxolol, betaxolol hydrochloride, bisoprolol, bisoprolol fumarate, bosentan, bumetanide, candesartan, candesartan cilexetil, carteolol, carteolol hydrochloride, carvedilol, carvedilol phosphate, chlorothiazide, chlorothiazide sodium, chlorthalidone, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, coenzyme q10, cyclothiazide, deserpidine, diltiazem, diltiazem hcl, diltiazem hydrochloride, diltiazem maleate, ditiaz, dong quai, doxazosin, doxazosin mesylate, eplerenone, epoprostenol, epoprostenol sodium, eprosartan, eprosartan mesylate, esmolol, esmolol hydrochloride, ethacrynate sodium, ethacrynic acid, felodipine, fish oil, fosinopril, fosinopril sodium, furosemide, garlic oil, guanabenz, guanabenz acetate, guanadrel, guanadrel sulfate, guanethidine, guanethidine monosulfate, guanfacine, guanfacine hydrochloride, hydralazine, hydralazine hydrochloride, hydrochlorothiazide, hydroflumethiazide, indapamide, irbesartan, isradipine, lisinopril, losartan, losartan potassium, methyclothiazide, methyldopa, methyldopate hydrochloride, metolazone, metoprolol, metoprolol succinate, metoprolol tartrate, mibefradil, mibefradil dihydrochloride, moexipril, moexipril hydrochloride, nadolol, nicardipine, nicardipine hydrochloride, nifedipine, nisoldipine, nitroglycerin, olmesartan, olmesartan medoxomil, penbutolol, penbutolol sulfate, perindopril, perindopril erbumine, pindolol, polythiazide, prazosin, prazosin hydrochloride, propranolol, propranolol hydrochloride, quinapril, quinapril hydrochloride, quinethazone, ramipril, reserpine, spironolactone, spironolactone pwdr [va product], telmisartan, terazosin, terazosin hydrochloride, timolol, timolol hemihydrate, timolol maleate, torsemide, trandolapril, treprostinil, triamterene, trichlormethiazide, valsartan, verapamil, verapamil hydrochloride

Cell-based therapeutics:

Endothelial progenitor cells, PMIDs: 17418297, 21653527

MalaCards organs/tissues related to pulmonary hypertension:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Lung -> Pulmonary Capillary Plexus	Affected by disease

MGI Mouse Phenotypes related to pulmonary hypertension:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	INF	RBPJ, VIPR1, MYBL1, BMPR1A, BMPR1B,
2	immune system phenotype	MP:0005387	INF	PDE4A, REN, RETNLB, SGCB, VWF, RBPJ
3	cardiovascular system phenotype	MP:0005385	INF	KLF6, PDE4A, REN, SGCB, VWF, SFTPC
4	growth/size phenotype	MP:0005378	INF	PIK3C2A, KLF6, PDE3B, REN, SGCB, SFTPC
5	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PDE3B, REN, RETNLB, VWF, RBPJ
6	nervous system phenotype	MP:0003631	INF	PDE4A, REN, VWF, RBPJ, SELP, SERPINC1
7	muscle phenotype	MP:0005369	INF	REN, SGCB, RBPJ, VEGFA, BMP4, BMPR1A
8	cellular phenotype	MP:0005384	INF	KLF6, VWF, PCNA, RBPJ, SELP, VIPR1
9	reproductive system phenotype	MP:0005389	INF	KLF6, PDE3A, REN, SFTPC, VIP, VEGFA
10	normal phenotype	MP:0002873	INF	PDE3A, REN, VIP, VEGFA, MYBL1, BMP2
11	vision/eye phenotype	MP:0005391	INF	SFTPC, SELP, SERPINC1, VEGFA, VEGFB, BMP4
12	embryogenesis phenotype	MP:0005380	INF	KLF6, RBPJ, SERPINC1, BMPR1B, BMPR2, RAC1
13	liver/biliary system phenotype	MP:0005370	INF	KLF6, SERPINC1, VEGFA, BMP4, , CD36
14	craniofacial phenotype	MP:0005382	INF	BMP4, BMPR1A, BMPR1B, , SATB2, ARNT
15	pigmentation phenotype	MP:0001186	9.8	PDE3B, RBPJ, SERPINC1, BMP7, BMPR1A, BMPR1B
16	hearing/vestibular/ear phenotype	MP:0005377	9.8	BMP2, BMP4, BMP7, BMPR1A, BAX, ASS1
17	behavior/neurological phenotype	MP:0005386	9.6	REN, SFTPC, RBPJ, SELP, VIP, VIPR1
18	other phenotype	MP:0005395	9.2	KDR, JAK2, CD40LG, FN1, FBN1, APOE
19	adipose tissue phenotype	MP:0005375	9.1	PIK3C2A, PDE3B, SERPINE1, MTOR, XDH, CD36
20	skeleton phenotype	MP:0005390	8.9	VEGFA, BMP2, BMP4, BMP6, BMP7, BMPR1A
21	tumorigenesis	MP:0002006	7.5	SFTPC, RBPJ, SERPINE1, BMPR1A, BCL2L1, B2M
22	digestive/alimentary phenotype	MP:0005381	INF	RETNLB, VWF, RBPJ, VIPR1, VEGFA, BMP2
23	hematopoietic system phenotype	MP:0005397	INF	KLF6, PCNA, RBPJ, MYBL1, BMP4, BMPR1A
24	integument phenotype	MP:0010771	INF	KLF6, PDE3B, RBPJ, SELP, MYBL1, RAC1
25	limbs/digits/tail phenotype	MP:0005371	INF	VEGFA, BMP2, BMP4, BMP7, BMPR1A, BMPR1B
26	mortality/aging	MP:0010768	INF	PIK3C2A, KLF6, REN, RETNLB, VWF, SFTPC
27	no phenotypic analysis	MP:0003012	INF	SFTPC, PCNA, VEGFA, BMP4, , FGFR1
28	renal/urinary system phenotype	MP:0005367	INF	REN, RBPJ, SELP, BMP4, BMP7,
29	respiratory system phenotype	MP:0005388	INF	SFTPC, RBPJ, SELP, BMPR1A, BMPR2,

Articles related to pulmonary hypertension:

(show top 50)    (show all 536)

id	Title	Authors	Year	Affiliating Genes
1	Autophagic protein LC3B confers resistance against hy poxia-induced pulmonary hypertension. (20889906)	Lee S.J.... Choi A.M.	2011	MAP1LC3B
2	Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades an d pulmonary hypertension. (20174619)	Shovlin C.L.... Mauri F.A.	2010	F8
3	Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. (19818875)	Sharma S.... Black S.M.	2009	ASS1, ASL
4	Pulmonary hypertension in peritoneal dialysis patients: prevalence and risk factors. (19293357)	Unal A.... Utas C.	2009	ALB
5	Expression of vasoactive intestinal peptide and relat ed receptors in overcirculation-induced pulmonary hypertension in piglets. (19581838)	Vuckovic A.... Naeije R.	2009	VIPR1, VIP, ADCYAP1
6	High plasma brain natriuretic peptide levels in stable COPD without pulmonary hypertension or Cor pulmonale. (19336951)	Inoue Y.... Aizawa H.	2009	NPPB
7	HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (19165231)	Kominami S.... Kimura A.	2009	HLA-A, HLA-DRB1, HLA-B
8	Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension. (19237250)	Tofovic S.P.... Rafikova O.	2009	ADA
9	Caveolin-1: a critical regulator of pulmonary vascular architecture and nitric oxide bioavailability in pulmonary hypertension. (18296499)	Ryter S.W.... Choi A.M.	2008	CAV1
10	Pulmonary hypertension in interstitial lung disease. (18515559)	Behr J.... Ryu J.H.	2008	NPPB
11	The role of bone morphogenetic protein-2 in the pathogenesis of hypoxic pulmonary hypertension (18070548)	Yang Y.... Chen W.B.	2007	BMP2
12	Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. (17641401)	Black S.M.... Fineman J.R.	2007	EDN1
13	Oxidative stress in patients with COPD and pulmonary hypertension. (17671825)	Joppa P.... TkA!covA! R.	2007	SOD1, CAT
14	Hemodynamic and clinical correlates of endothelin-1 in chronic thromboembolic pulmonary hypertension. (16864942)	Reesink H.J.... Bresser P.	2006	EDN1
15	Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung. (15761249)	Lee Y.S.... Kim D.K.	2005	CTGF
16	Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. (16027259)	Song Y.... Zhang Y.Y.	2005	ALOX5
17	BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension. (15965979)	Sankelo M.... Laitinen T.	2005	BMPR2
18	Bone morphogenetic protein 4 promotes vascular remodeling in hypoxic pulmonary hypertension. (16373851)	Frank D.... de Caestecker M.	2005	BMP4
19	Study on the effect of adrenomedulin and urotensin-II on pulmonary hypertension of patients with congenital heart disease (16324296)	Wang T.... Wu S.M.	2005	UTS2
20	Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. (15775752)	Cogan J.D.... Loyd J.E.	2005	BMPR2
21	Brain-type natriuretic peptide in the diagnosis and management of persistent pulmonary hypertension of the newborn. (15805406)	Baptista M.J.... Areias J.C.	2005	NPPB
22	Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats. (14966819)	Dai Z.K.... Wu J.R.	2004	NOS3, EDN1
23	Brain natriuretic peptide: is it helpful in detecting pulmonary hypertension in fibrotic lung disease? (15302622)	Hill N.S.	2004	NPPB
24	Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. (15192043)	Takeda M.... Makino H.	2004	BMPR1B
25	Signaling molecules in nonfamilial pulmonary hypertension. (12571257)	Du L.... Thistlethwaite P.A.	2003	TEK, BMPR1A, BMPR2
26	Intermittent epoprostenol infusions in systemic lupus erythematosus associated pulmonary hypertension--a series of three cases. (12625109)	Kong K.O.... Chng H.H.	2003	TIMP1
27	Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. (14684682)	Harrison R.E.... Trembath R.C.	2003	BMPR2, ACVRL1, BMP6
28	The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn piglets. (12788984)	Navarrete C.T.... Suguihara C.	2003	EDN1
29	High prevalence of elevated clotting factor VIII in chronic thromboembolic pulmonary hypertension. (12958604)	Bonderman D.... Lang I.M.	2003	F8
30	Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension? (12024106)	Eddahibi S.... Adnot S.	2002	SLC6A4
31	Characterization of high-altitude pulmonary hypertension in the Kyrgyz: association with angiotensin-converting enzyme genotype. (12406857)	Aldashev A.A.... Morrell N.W.	2002	ACE
32	Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. (12019369)	Suhara H.... Matsuda H.	2002	EDN1, PTGIS
33	HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. (11238043)	Golpon H.A.... Voelkel N.F.	2001	HOXA5, HOXB2, HOXB6
34	Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. (11133493)	Fujita M.... Mason R.J.	2001	TNF
35	Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. (11602621)	Eddahibi S.... Adnot S.	2001	SLC6A4
36	Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension. (11536448)	Asikainen T.M.... Raivio K.O.	2001	SOD2
37	Recombinant human superoxide dismutase enhances the e ffect of inhaled nitric oxide in persistent pulmonary hypertension. (11549542)	Steinhorn R.H.... Davis J.M.	2001	SOD1
38	Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. (11713135)	Rubens C.... Hoeffken G.	2001	EDN1
39	Cellular pathophysiology and therapy of pulmonary hypertension. (11753283)	Olschewski H.... Seeger W.	2001	BMPR2
40	Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. (11104729)	Partovian C.... Eddahibi S.	2000	EDN1
41	Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF- beta family. (11015450)	Thomson J.R.... Nichols W.C.	2000	BMPR2
42	Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension? (10444023)	MacLean M.R.	1999	EDN1
43	Factor V Leiden is not common in patients diagnosed w ith primary pulmonary hypertension. (9864017)	Elliott C.G.... Pietra G.G.	1998	F5
44	Altered hemostasis in pulmonary hypertension. (9622208)	Hassell K.L.	1998	THBD
45	Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. (9032045)	Roberts J.D.... Zapol W.M.	1997	HBG2
46	Mechanism of plasma endothelin-1 level elevation and its relation with pulmonary hypertension in chronic cor pulmonale (9275630)	Zhang J.... Wang C.	1996	EDN1
47	EndothelinB receptor-mediated contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on endothelin responses in the rat. (8587353)	McCulloch K.M.... MacLean M.R.	1995	EDN1
48	Familial pulmonary hypertension in association with an abnormal hemoglobin. Insights into the pathogenesis of primary pulmonary hypertension. (1708327)	Rich S.... Hart K.	1991	FGA
49	Pulmonary peptides, norepinephrine and endocrine cells in monocrotaline pulmonary hypertension. (1832315)	O'Neill D.... Heath D.	1991	NTS
50	Atrial natriuretic peptide in primary pulmonary hypertension. (2149841)	Morice A.H.... Higenbottam T.W.	1990	NPPA

Genes related to pulmonary hypertension according to GeneCards:

(show top 50)    (show all 236)

id	Symbol	Description	Score	GeneCards Section Context
1	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	11.1	Aliases & Descriptions, Summaries, Publications
2	BMPR1B	bone morphogenetic protein receptor, type IB	11.1	Publications, Summaries
3	CPS1	carbamoyl-phosphate synthase 1, mitochondrial	11.1	Summaries, Publications
4	CTEPH1	Pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to	11.1	Aliases & Descriptions
5	PPH2	primary pulmonary hypertension 2	11.1	Aliases & Descriptions, Publications
6	NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	11.0	Summaries
7	ADM	adrenomedullin	11.0	Publications
8	EDN1	endothelin 1	11.0	Publications
9	PDE5A	phosphodiesterase 5A, cGMP-specific	11.0	Publications
10	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
11	BMP2	bone morphogenetic protein 2	11.0	Publications
12	ACVRL1	activin A receptor type II-like 1	11.0	Publications
13	NPPB	natriuretic peptide B	11.0	Publications
14	FGA	fibrinogen alpha chain	11.0	Publications
15	NPPA	natriuretic peptide A	11.0	Publications
16	THBD	thrombomodulin	11.0	Publications
17	SMAD9	SMAD family member 9	11.0
18	FBN1	fibrillin 1	11.0	Publications
19	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
20	VWF	von Willebrand factor	11.0	Publications
21	BMP6	bone morphogenetic protein 6	11.0	Publications
22	DYNLT1	dynein, light chain, Tctex-type 1	11.0	Publications
23	HMGN2	high mobility group nucleosomal binding domain 2	11.0	Publications
24	HOXA5	homeobox A5	11.0	Publications
25	HOXB2	homeobox B2	11.0	Publications
26	HOXB6	homeobox B6	11.0	Publications
27	SARS2	seryl-tRNA synthetase 2, mitochondrial	11.0	Publications
28	PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	11.0	Publications
29	PTGIS	prostaglandin I2 (prostacyclin) synthase	11.0	Publications
30	HBG2	hemoglobin, gamma G	11.0	Publications
31	TRAK2	trafficking protein, kinesin binding 2	11.0	Publications
32	AIRE	autoimmune regulator	11.0	Publications
33	ICOS	inducible T-cell co-stimulator	11.0	Publications
34	WNT2	wingless-type MMTV integration site family member 2	11.0	Publications
35	BMP4	bone morphogenetic protein 4	11.0	Publications
36	BZW1	basic leucine zipper and W2 domains 1	11.0	Publications
37	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0	Publications
38	PF4	platelet factor 4	11.0	Publications
39	ABI2	abl-interactor 2	11.0	Publications
40	SMAD1	SMAD family member 1	11.0
41	ACVR2A	activin A receptor, type IIA	11.0	Publications
42	TRIM21	tripartite motif containing 21	11.0	Publications
43	SATB2	SATB homeobox 2	11.0	Publications
44	BMP7	bone morphogenetic protein 7	11.0	Publications
45	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
46	ACVR1	activin A receptor, type I	11.0	Publications
47	TGFBR3	transforming growth factor, beta receptor III	11.0	Publications
48	APOC3	apolipoprotein C-III	11.0	Publications
49	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
50	SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	11.0	Publications

Pathways related to pulmonary hypertension according to GeneDecks:

(show top 50)    (show all 127)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	10.3	PDE3B, VEGFB, BMP2, BMP4, BMP7, BMPR1A
2	JNK Pathway36	10.3	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
3	TGF-beta signaling pathway20	10.2	BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B
4	Telomerase Components in Cell Signaling36	10.2	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
5	Rac1 Pathway36	10.1	VEGFB, BMP4, BMP6, BMP7, RAC1, UTS2
6	Apoptotic Pathways in Synovial Fibroblasts36	10.1	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
7	p53 Mediated Apoptosis36	10.0	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
8	Mitochondrial Apoptosis36	9.8	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
9	Activation of PKC through GPCR36	9.7	PDE3A, PDE3B, VEGFB, BMP2, BMP4, BMP6
10	p70S6K Signaling36	9.7	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
11	PGC1Alpha Pathway36	9.5	BMP2, BMP4, BMP6, BMP7, BAX, IL1A
12	Cellular Apoptosis Pathway36	9.5	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
13	Intracellular Calcium Signaling36	9.5	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
14	DHA Signaling36	9.5	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
15	NF-KappaB (p50-p65) Pathway36	9.4	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
16	NF-KappaB Family Pathway36	9.4	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
17	PPAR Pathway36	9.4	VEGFB, BMP2, BMP4, UTS2, FLT1, FGF2
18	Angiogenesis3	9.3	REN, VEGFB, KDR, MMP9, FLT1, ARNT
19	Renin-Angiotensin Pathway36	9.2	REN, VEGFB, BMP2, BMP4, BMP6, BMP7
20	GPCR Pathway36	9.1	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
21	Nanog in Mammalian ESC Pluripotency36	9.1	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
22	all-trans-Retinoic Acid Signaling in Brain36	9.0	BMP2, BMP4, BMP6, BMP7, BAX, IL10
23	Molecular Mechanisms of Cancer36	8.7	BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B
24	ERK Signaling36	8.6	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
25	Endothelin-1 Signaling Pathway36	8.6	BMP2, BMP4, BMP6, BMP7, FLT1, IL10
26	STAT3 Pathway36	8.5	BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B
27	Rho Family GTPases36	8.3	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
28	Cytokine-cytokine receptor interaction20	8.3	VEGFA, VEGFB, BMP2, BMP7, BMPR1A, BMPR1B
29	MAPK Signaling36	8.3	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
30	PEDF Induced Signaling36	8.3	BMP2, BMP4, BMP6, BMP7, BCL2L1, BAX
31	MIF Mediated Glucocorticoid Regulation36	8.3	BMP2, BMP4, BMP6, BMP7, BAX, IL10
32	MIF Regulation of Innate Immune Cells36	8.3	BMP2, BMP4, BMP6, BMP7, BAX, IL10
33	TGF-Beta Pathway36	8.2	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
34	Rheumatoid arthritis20	8.1	VEGFA, VEGFB, FLT1, IL1A, IL1B, IL6
35	p38 Signaling36	8.1	VEGFB, BMP2, BMP4, BMP6, BMP7, BMPR1A
36	MAPK Family Pathway36	7.9	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
37	Pathways in cancer20	7.9	VEGFA, VEGFB, BMP2, BMP4, RAC1, BCL2L1
38	Pancreatic Adenocarcinoma36	7.7	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
39	JAK-STAT Pathway36	7.6	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
40	Paxillin Interactions36	INF	VEGFB, BMP2, BMP4, RAC1, UTS2, KDR
41	Tec Kinases Signaling36	INF	VEGFB, BMP2, BMP4, BMP6, BMP7, BMPR1A
42	PTEN Pathway36	INF	VEGFB, BMP2, BMP4, BMP7, RAC1, UTS2
43	Ras Pathway36	INF	VEGFB, BMP2, BMP4, BMP7, UTS2, KDR
44	Antioxidant Action of Vitamin-C36	INF	VEGFB, BMP2, BMP4, BMP6, BMP7, BMPR1A
45	Actin-Based Motility by Rho Family GTPases36	INF	BMP4, BMP7, UTS2, CTGF, , ACTG1
46	PAK Pathway36	INF	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
47	NFAT in Immune Response36	INF	VEGFB, BMP2, BMP4, BMP6, BMP7, UTS2
48	ILK Signaling36	INF	VEGFB, BMP2, BMP4, BMP7, RAC1, UTS2
49	Epithelial Adherens Junctions36	INF	VEGFB, BMP2, BMP4, BMP6, BMP7, RAC1
50	eNOS Signaling36	INF	BMP2, BMP6, BMP7, UTS2, FGFR1, ALK

Compounds related to pulmonary hypertension according to GeneDecks:

(show top 50)    (show all 515)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	INF	KLF6, PDE3A, PDE3B, PDE4A, REN, SGCB
2	thromboxane32 18	12.4	PIK3C2A, PDE4A, VWF, SELP, FGA, APOH
3	lysine32	11.3	SFTPC, YY1, ARNT, ARG1, FBN1, CCL3
4	phosphoramidon32 9 9	13.0	VIP, GRP, NTS, EDN1, EDN2, EDN3
5	glucose32	10.9	PDE4A, GCH1, VIPR1, BMP7, ARNT, FGFR1
6	guanylate32	10.9	PDE3B, SGCB, VIP, FLT1, ANGPT1, HMOX1
7	heparan sulfate32 18	11.7	SERPINC1, SERPINE1, BMP2, BMP4, BMP6, KDR
8	nicotine32 34 9 9	13.6	BMP2, GRP, PTHLH
9	warfarin32 34 9 18 9	14.4	PIK3C2A, VWF, SELP, SERPINC1, FGA, FGF2
10	aprotinin32 9 9	12.3	VWF, SELP, SERPINC1, VIP, MMP9, FN1
11	homocysteine32 18	11.2	PIK3C2A, VWF, SELP, SERPINC1, SERPINE1, MTR
12	histamine32 18	11.0	PDE3B, PDE4A, SGCB, VWF, PCNA, SELP
13	polyethylene glycol32	10.0	SERPINC1, VIP, BMP2, FN1, APOA1, APOE
14	calcitriol32 42 9 18 9	13.9	REN, BMP2, BMP6, BMP7, B2M, CD36
15	arginine32	9.9	PIK3C2A, PDE4A, REN, SGCB, VWF, SFTPC
16	protamine32	9.9	SELP, SERPINC1, SERPINE1, FGA, FGF2, IL6
17	enalapril32 9 9	11.8	REN, SERPINE1, VIP, BMP6, BMP7, IL10
18	oxygen32 18	10.8	PIK3C2A, SGCB, SFTPC, GCH1, VEGFB, BMP2
19	aspirin32 34 18	11.7	PDE4A, VWF, PCNA, SELP, SERPINC1, SERPINE1
20	theophylline32 9 18 9	12.7	PDE3A, PDE3B, PDE4A, SELP, XDH, B2M
21	tgf beta132	9.6	SERPINE1, BMP6, BMP7, KDR, CD36, FN1
22	uric acid32 18	10.6	PIK3C2A, SERPINE1, XDH, B2M, IL1R1, APOA1
23	ang ii32	9.5	REN, VEGFA, JAK2, CD36, MAPK1, CCL2
24	n acetylcysteine32	9.0	SGCB, VWF, PCNA, SELP, SERPINC1, UTS2
25	atp32	9.0	PIK3C2A, PDE3B, PDE4A, SGCB, RAC1, USO1
26	tacrolimus32 34 9 9	11.7	REN, PCNA, SERPINE1, BMP2, BMP6, YY1
27	suramin32 9 9	10.7	PCNA, VIP, VEGFA, BMP6, KDR, FGF2
28	5fluorouracil32	8.7	PCNA, VEGFA, KDR, BCL2L1, BAX, MTOR
29	adp32 18	9.6	PIK3C2A, KLF6, VWF, SELP, SERPINC1, BMPR1A
30	adenylate32	8.6	KLF6, PDE3A, PDE3B, PDE4A, SGCB, VWF
31	tetracycline32 9 9	10.6	VWF, SFTPC, BMP2, RAC1, CD40LG, MMP9
32	atorvastatin32 34 9 18 9	12.5	PIK3C2A, VWF, SELP, SERPINE1, VEGFA, BMP2
33	neopterin32	8.4	GCH1, B2M, CD40LG, IL10, IL1A, IL1B
34	cyclosporin a32 42	9.3	PIK3C2A, PDE4A, VWF, SELP, VIP, BMP2
35	alpha tocopherol32	8.0	XDH, CD36, MMP9, APOA1, APOE, ALB
36	sb 20358032 42	8.9	VEGFA, BMP2, BMP4, BMP6, RAC1, BCL2L1
37	mg 13232 42	8.9	PCNA, KDR, BCL2L1, BAX, JAK2, IL1A
38	simvastatin32 34 42 9 18 9	12.8	PIK3C2A, VWF, SELP, SERPINE1, VEGFA, BMP2
39	celecoxib32 42 34 9 18 9	12.2	REN, PCNA, VEGFA, KDR, BAX, MMP9
40	cisplatin32 34 9 9	10.2	PIK3C2A, PCNA, VEGFA, BMP6, RAC1, KDR
41	troglitazone32 42 9 9	10.2	SERPINE1, BMP6, BAX, CD36, MMP9, FN1
42	methotrexate32 34 42 9 9	10.8	PIK3C2A, PCNA, SERPINE1, BMP6, MTR, MMP9
43	dexamethasone32 42 34 9 9	9.4	PDE4A, REN, VWF, SFTPC, PCNA, SELP
44	forskolin32 42 9 9	INF	PDE3A, PDE3B, PDE4A, REN, SGCB, VIP
45	cytochalasin d32 42	INF	VWF, RAC1, JAK2, CD36, CDC42, MMP9
46	calcium32 9 18 9	INF	PIK3C2A, PDE3B, PDE4A, REN, SGCB, VWF
47	cyclic amp32 18	INF	KLF6, PDE3A, PDE3B, PDE4A, SGCB, SFTPC
48	matrigel32	INF	VWF, SERPINE1, VEGFA, BMP2, BMP6, RAC1
49	doxorubicin32 34 9 9	INF	PIK3C2A, BMP6, KDR, BCL2L1, MTOR, B2M
50	cysteine32	INF	PDE3A, RETNLB, SGCB, SFTPC, PCNA, SELP

Cellular components related to pulmonary hypertension according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PDE4A, PIK3C2A, PDE3A, PDE3B, ACTG1, ACTG2
2	extracellular matrix	GO:031012	10.8	SOD3, SOD1, PLAT, TNC, F3, APOH
3	cell surface	GO:009986	10.1	TNF, TEK, PLAT, ACVR2A, ACVRL1, ELANE
4	platelet alpha granule lumen	GO:031093	10.1	HGF, FGB, F8, F5, ALB, F13A1
5	external side of plasma membrane	GO:009897	9.8	HLA-DRB1, TNF, CTLA4, ACE, TGFBR2, TGFBR3
6	caveola	GO:005901	9.7	TRPC4, PTGIS, PTGS2, NOS3, TGFBR2, HMOX1
7	neuronal cell body	GO:043025	9.6	SST, ACVRL1, TGFB1, SOD1, RTN4, ADCY10
8	integral to plasma membrane	GO:005887	9.2	CTLA4, TBXA2R, PTGIR, TEK, TNF, TPO
9	plasma membrane	GO:005886	8.0	WNT2, TNF, TEK, PTGER4, PTGIR, PTGS1
10	extracellular space	GO:005615	6.6	SST, CTGF, CRP, PLAT, PF4, EDN1
11	extracellular region	GO:005576	INF	EPO, TEK, PTHLH, SST, CTGF, NTS
12	cytoplasm	GO:005737	INF	PTGS1, PTHLH, PTK2, SUMO1, CTH, SMAD1

Biological processes related to pulmonary hypertension according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:007596	INF	F13A1, THBD, THPO, TGFB1, TF, PRKG1
2	BMP signaling pathway	GO:030509	INF	ACVR1, ACVR2A, SMAD9, SMAD4, SMAD1, ACVRL1
3	heart development	GO:007507	INF	TEK, ADM, EDNRA, ECE1, EDN1, PCNA
4	positive regulation of transcription, DNA-dependent	GO:045893	INF	EPO, AIRE, , KLF6, PPARG, TNF
5	vasculogenesis	GO:001570	INF	ADM, VEGFA, , KDR, ,
6	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	11.6	BMP4, BMP6, BMP7, BMPR1A, BMPR2, INHBA
7	positive regulation of bone mineralization	GO:030501	11.3	ACVR2A, BMPR2, BMPR1B, BMPR1A, BMP7, BMP6
8	positive regulation of osteoblast differentiation	GO:045669	11.2	NPPC, BMPR2, FGF2, BMP4, SMAD1, IL6
9	vasoconstriction	GO:042310	11.1	HTR2B, CAV1, EDN1, EDN2, EDN3, EDNRA
10	negative regulation of cell growth	GO:030308	11.1	AGT, TGFB1, SMAD4, PPARG, ACVRL1, CTH
11	positive regulation of vasodilation	GO:045909	11.1	NPPC, CPS1, ADM, EPHX2, AGTR2, NOS3
12	positive regulation of endothelial cell proliferation	GO:001938	11.0	VEGFA, VEGFB, BMP4, BMP6, BMPR2, KDR
13	regulation of vasoconstriction	GO:019229	10.9	EDN1, EDN2, EDN3, ACE, AGT, NPPC
14	blood vessel remodeling	GO:001974	10.7	EPAS1, AGTR2, AGT, ELN, ACVRL1, NOS3
15	aging	GO:007568	10.4	NOS3, EDNRA, PTGS1, HTR2A, F3, CCL5
16	response to amino acid stimulus	GO:043200	10.4	MTOR, ARG1, CCL2, SST, NOS3, EDN1
17	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.3	KDR, JAK2, FLT1, FGFR1, ANGPT1, CCL5
18	positive regulation of MAP kinase activity	GO:043406	10.1	TGFB1, EGFR, EDN3, EDN1, PDE5A, HTR2A
19	response to lipopolysaccharide	GO:032496	10.1	EPO, ADM, CPS1, THPO, THBD, ELANE
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	IL1A, KDR, BMP4, BMP2, F2RL1, CCL3
21	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	HIF1A, ELANE, EDN1, PTGS2, TNF, HMOX1
22	angiogenesis	GO:001525	9.9	SERPINE1, HIF1A, TGFA, EPAS1, PGF, PDE3B
23	positive regulation of protein phosphorylation	GO:001934	9.9	BMP2, BMP4, MTOR, IL1B, TGFB1, F2
24	platelet degranulation	GO:002576	9.8	VWF, SELP, SERPINE1, VEGFA, VEGFB, CD36
25	positive regulation of protein kinase B signaling cascade	GO:051897	9.8	VEGFB, MTOR, ANGPT1, F3, TNF, TEK
26	cellular response to hypoxia	GO:071456	9.7	MTOR, VEGFA, BMP7, ARNT, HMOX1, EPO
27	positive regulation of cell division	GO:051781	9.6	VEGFB, TGFB1, TGFA, CAT, HTR2B, IL1B
28	response to hyperoxia	GO:055093	9.5	MMP9, NOS3, CAT, ALOX5, EPO, SFTPC
29	positive regulation of nitric oxide biosynthetic process	GO:045429	9.4	DDAH1, AGTR2, HBB, EGFR, EDN1, DDAH2
30	G-protein coupled receptor signaling pathway	GO:007186	9.3	CCL2, SST, JAK2, TBXA2R, APOC3, APOE
31	response to glucocorticoid stimulus	GO:051384	9.3	SERPINE1, SFTPC, ADM, PLAT, IL10, IL6
32	negative regulation of cell proliferation	GO:008285	9.2	CTH, SST, PTHLH, INHBA, PTGS2, TNF
33	MAPK cascade	GO:000165	9.0	IL1B, MAPK1, CCL2, CCL3, FGFR1, CCL5
34	positive regulation of apoptotic process	GO:043065	8.9	SOD1, JAK2, BMP4, TNF, ADCY10, BAX
35	inflammatory response	GO:006954	8.8	TBXA2R, PTGS2, TNF, CCL5, CCL3, CCL11
36	platelet activation	GO:030168	8.8	VWF, SELP, SERPINE1, VEGFA, VEGFB, RAC1
37	positive regulation of cell migration	GO:030335	INF	FLT1, CCL3, CCL5, F3, F2RL1, PTK2
38	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	AIRE, HOXA5, F2RL1, CCNC, ENG, IL6
39	positive regulation of angiogenesis	GO:045766	INF	, ADM, TEK, HMOX1, F3, PTGIS
40	transforming growth factor beta receptor signaling pathway	GO:007179	INF	TGFBR3, ACVR1, SMAD1, CCL2, CCNC, ENG
41	response to drug	GO:042493	INF	, SST, TBXA2R, PTGS2, TNF, CAV1
42	negative regulation of apoptotic process	GO:043066	INF	BMP4, KDR, BCL2L1, FGFR1, IL6, ANGPT1
43	cell-cell signaling	GO:007267	INF	PTHLH, BMP2, INHBA, GREM1, EDN3, PGF
44	response to hypoxia	GO:001666	INF	PLAT, ADA, EPAS1, ADM, ECE1, PGF
45	negative regulation of inflammatory response	GO:050728	INF	ELANE, GBA, SERPINC1, , APOA1, APOE
46	in utero embryonic development	GO:001701	INF	BMP2, , , TGFBR2, ACVRL1, ACVR1
47	positive regulation of cell proliferation	GO:008284	INF	VIP, VIPR1, VEGFA, KDR, BCL2L1, JAK2
48	anti-apoptosis	GO:006916	INF	HMOX1, IL1A, IL1B, APOE, ANXA5, ANGPT1
49	regulation of blood pressure	GO:008217	INF	REN, GCH1, UTS2, HMOX1, PTGS2, PTGS1
50	cellular response to organic cyclic compound	GO:071407	INF	BMP2, TGFB1, , IL1B, CCL2, CCL5

Molecular functions related to pulmonary hypertension according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta-activated receptor activity	GO:005024	11.0	TGFBR3, TGFBR2, ACVRL1, ACVR2A, ENG, BMPR2
2	hormone activity	GO:005179	11.0	EPO, UTS2D, UTS2, VIP, RETNLB, INHBA
3	transmembrane receptor protein serine/threonine kinase activity	GO:004675	10.9	TGFBR2, ACVRL1, ACVR1, ACVR2A, BMPR1B, BMPR1A
4	receptor binding	GO:005102	10.9	GBA, EPHX2, ADCYAP1, ADM, NPPC, NPPB
5	transforming growth factor beta binding	GO:050431	10.7	TGFBR3, TGFBR2, ACVRL1, ACVR1, ENG, CD36
6	peptide hormone receptor binding	GO:051428	10.5	ADCYAP1, NPPC, NPPB, NPPA, PTHLH, JAK2
7	eukaryotic cell surface binding	GO:043499	10.4	EPO, TGFB1, ANXA5, APOH, FGB, FGA
8	heparin binding	GO:008201	10.2	CCL2, CCL5, CTGF, PF4, ELANE, TGFBR3
9	chemoattractant activity	GO:042056	9.9	CCL5, CCL3, FGF2, BMP4, VEGFB, VEGFA
10	growth factor activity	GO:008083	9.5	IL6, F2, CTGF, AGT, THPO, TGFA
11	enzyme binding	GO:019899	9.5	TOP2A, HIF1A, EGFR, NOTCH3, PPARG, PTGS2
12	cytokine activity	GO:005125	9.1	IL1A, IL1B, IL5, IL6, TNF, EDN1
13	identical protein binding	GO:042802	9.0	AIRE, TNF, DYNLT1, SMAD1, SMAD4, NOL3
14	protein homodimerization activity	GO:042803	INF	SOD1, CCL5, ENG, APOE, FGFR1, XDH
15	protein binding	GO:005515	INF	TF, TGFBR3, TGFBR2, TGFB1, TGFA, THBD
16	protein heterodimerization activity	GO:046982	INF	HIF1A, AGTR1, TOP2A, TGFB1, , PGF
17	SMAD binding	GO:046332	INF	TGFBR3, TGFBR2, ACVRL1, ACVR1, SMAD2,