MCID: PLM038
MIFTS: 44

Pulmonary Large Cell Neuroendocrine Carcinoma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

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33MalaCards
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MalaCards: Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell neuroendocrine carcinoma, is related to neuroendocrine carcinoma and large cell carcinoma. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are TP53 network and Signaling mediated by p38-alpha and p38-beta. The compounds griseofulvin and diethyl dithiocarbamate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pulmonary large cell neuroendocrine carcinoma 8 10
large cell neuroendocrine carcinoma 62


External Ids:

Disease Ontology8 DOID:6658
SNOMED-CT58 128628002
NCIt40 C6875

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.2TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
2large cell carcinoma30.7KRT7, NKX2-1, TP63
3neuroendocrine tumor30.5NKX2-1, KRT8, KRT19
4lung cancer30.4TP63, NKX2-1, KRT8, KRT18, KRT19, CDKN2A
5large cell neuroendocrine carcinoma11.0
6small cell carcinoma10.3
7prostatitis10.3
8lambert syndrome10.3
9nephrogenic adenoma10.1KRT7
10leukoplakia10.1KRT8
11sex cord-gonadal stromal tumor10.1KRT7, NKX2-1
12bronchiolo-alveolar adenocarcinoma10.1NKX2-1, KRT7
13actinic keratosis10.1TP63
14teratoma10.1KRT7, NKX2-1
15bile duct adenoma10.1KRT7, KRT19
16follicular thyroid carcinoma10.1NKX2-1, KRT19
17bowen syndrome10.1KRT19, KRT7
18barrett's esophagus10.1CDKN2A, KRT7
19merkel cell carcinoma10.0KRT8, NKX2-1
20follicular adenoma10.0KRT19, NKX2-1
21epithelioid sarcoma10.0KRT7, KRT8
22pancreatic ductal carcinoma10.0KRT7, KRT8
23gallbladder cancer10.0KRT8, KRT7
24cirrhosis, noncryptogenic10.0KRT8, KRT18
25cervical intraepithelial neoplasia10.0CDKN2A, KRT8
26alcoholic hepatitis10.0KRT8, KRT18
27hepatoblastoma10.0KRT18, KRT7
28angiosarcoma10.0KRT8, KRT18
29intraocular melanoma10.0CDKN2A, KRT8
30autoimmune hepatitis10.0KRT8, KRT18
31tubular adenocarcinoma10.0KRT7, TP63
32primary biliary cirrhosis10.0KRT19, KRT7
33mucoepidermoid carcinoma10.0TP63, KRT7
34viral hepatitis10.0KRT8, KRT18
35abrikosov's tumor10.0NKX2-1, KRT8, KRT7
36hepatitis10.0KRT8, KRT18
37thymoma10.0NKX2-1, TP63
38cork-handlers' disease10.0KRT19, KRT18, NKX2-1
39pleomorphic adenoma10.0TP63, KRT18
40cervical adenocarcinoma10.0KRT8, KRT7, CDKN2A
41breast fibroadenoma10.0TP63, KRT8
42oral cancer10.0CDKN2A, KRT19
43autoimmune thyroiditis10.0KRT19, TP63
44synovial sarcoma10.0KRT8, KRT7, KRT19
45papilloma10.0TP63, CDKN2A
46pancreatitis, chronic10.0KRT8, KRT18
47leiomyosarcoma10.0KRT8, TP63
48thyroid cancer10.0KRT19, NKX2-1
49benign mesothelioma10.0CDKN2A, KRT19, KRT7, NKX2-1
50papillary thyroid carcinoma10.0KRT19, NKX2-1, TP63

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to pulmonary large cell neuroendocrine carcinoma

Symptoms for Pulmonary Large Cell Neuroendocrine Carcinoma

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Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Large Cell Neuroendocrine Carcinoma

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

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Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

33
Lung, Brain, Prostate

Animal Models for Pulmonary Large Cell Neuroendocrine Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5TP63, NKX2-1, KRT8, KRT19, CDKN2A
2MP:00020068.5NKX2-1, KRT19, CDKN2A, TP63
3MP:00053798.3VGF, CDKN2A, KRT19, NKX2-1, TP63
4MP:00053808.3KRT18, TP63, CDKN2A, KRT19, KRT8
5MP:00053898.1CDKN2A, KRT19, KRT8, NKX2-1, TP63, VGF
6MP:00053848.0NKX2-1, TP63, KRT7, KRT19, CDKN2A
7MP:00053787.7VGF, TP63, KRT8, KRT18, CDKN2A, NKX2-1
8MP:00107687.6CDKN2A, KRT19, KRT18, KRT8, NKX2-1, TP63

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

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52PubMed
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Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 25)
idTitleAuthorsYear
1
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
2
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. (24023298)
2013
3
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
4
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
5
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. (22359531)
2012
6
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
7
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. (21918393)
2011
8
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. (22977617)
2011
9
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (20398190)
2010
10
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. (19619794)
2009
11
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. (20082272)
2009
12
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
13
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
14
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
15
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. (16862075)
2006
16
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
17
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. (15538626)
2005
18
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
19
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
20
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. (15172230)
2004
21
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. (14719055)
2004
22
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
23
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. (11391577)
2001
24
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. (11505281)
2001
25
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

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Expression for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 60Thomson Reuters
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Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TP63, CDKN2A
29.5KRT8, KRT19
38.9KRT8, KRT7, KRT18
48.3KRT7, KRT18, KRT19, KRT8
58.3KRT19, KRT8, KRT7, KRT18

Compounds for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1griseofulvin45 1111.1KRT18, KRT8
2diethyl dithiocarbamate459.8KRT8, KRT18
3doxycycline45 1110.8CDKN2A, KRT18
4gold459.7KRT8, KRT18, CDKN2A
5agar459.6KRT8, KRT18, CDKN2A
6fitc459.6KRT8, KRT18, KRT19
7p005459.6TP63, KRT19
8adriamycin459.5KRT19, KRT8, CDKN2A
9sucrose45 24 1111.5KRT8, KRT19, KRT18
10urea45 24 1111.4KRT18, LCN1, KRT8
11paclitaxel45 51 1111.4KRT8, KRT19, CDKN2A
12actinomycin d459.3KRT18, CDKN2A, KRT8
13oligonucleotide459.3KRT8, NKX2-1, KRT18, CDKN2A
14mucicarmine459.3TP63, KRT7, NKX2-1
15doxorubicin45 51 1111.3KRT18, CDKN2A, TP63, KRT8
16threonine459.2KRT18, CDKN2A, KRT8, NKX2-1
17n-acetylglucosamine459.2KRT18, KRT8, KRT7
18forskolin45 51 1111.2VGF, KRT8, KRT18, NKX2-1
19butyrate459.2CDKN2A, KRT19, KRT18, KRT8
20methanol45 2410.2KRT7, CDKN2A
21chloride459.2LCN1, KRT19, KRT8
22bromodeoxyuridine459.1KRT19, TP63, KRT8, KRT18
23cisplatin45 51 61 1112.1KRT19, CDKN2A, TP63, KRT8
24thymidine45 2410.0VGF, TP63, KRT18, KRT19
25aspartate458.9CDKN2A, LCN1, KRT18, KRT19
26atp45 299.9KRT8, KRT18, CDKN2A, KRT19
27lactate458.9KRT19, KRT18, LCN1, KRT8
28formaldehyde45 249.8KRT19, KRT7, NKX2-1, KRT18
29oxygen45 249.8LCN1, KRT18, KRT19, CDKN2A
30serine458.8CDKN2A, KRT19, KRT18, KRT8, NKX2-1
31retinoid458.7KRT8, KRT7, KRT18, KRT19
32glycogen45 249.7KRT7, KRT8, KRT18, KRT19
33creatinine458.6KRT19, CDKN2A, KRT18, KRT8, LCN1
34steroid458.5CDKN2A, NKX2-1, TP63, KRT8, KRT18, KRT19
35b 723458.4NKX2-1, KRT8, KRT7, KRT19, TP63
36matrigel458.3KRT19, TP63, KRT7, KRT8, KRT18
37lipid458.2LCN1, KRT18, KRT8, KRT7, CDKN2A
38testosterone45 61 24 1111.0KRT19, KRT18, TP63, CDKN2A, KRT8, KRT7
39calcium45 51 24 1110.8LCN1, TP63, CDKN2A, KRT8, KRT19
40iron45 248.8KRT7, CDKN2A, LCN1, KRT8, KRT18, KRT19
41glucose457.8CDKN2A, KRT19, KRT18, KRT8, LCN1, KRT7
42hematoxylin457.7KRT7, NKX2-1, KRT8, KRT18, KRT19, CDKN2A
43paraffin457.7TP63, KRT18, KRT19, CDKN2A, KRT8, KRT7
44progesterone45 29 61 24 1111.7KRT18, KRT7, KRT8, NKX2-1, TP63, CDKN2A
45estrogen457.7TP63, KRT19, CDKN2A, KRT18, KRT8, NKX2-1
46retinoic acid45 248.7CDKN2A, KRT19, KRT18, KRT7, KRT8, NKX2-1
47tyrosine457.5KRT18, VGF, TP63, NKX2-1, KRT8, KRT19
48vegf457.5KRT7, VGF, TP63, KRT8, KRT18, KRT19

GO Terms for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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16Gene Ontology
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Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dystrophin-associated glycoprotein complexGO:0160109.5KRT8, KRT19
2sarcolemmaGO:0423839.5KRT19, KRT8
3costamereGO:0430349.4KRT19, KRT8
4keratin filamentGO:0450958.9KRT8, KRT7, KRT18
5nucleoplasmGO:0056548.6TP63, NKX2-1, KRT8, CDKN2A
6intermediate filamentGO:0058828.5KRT19, KRT18, KRT7, KRT8

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:0972849.8KRT18, KRT8
2cell differentiation involved in embryonic placenta developmentGO:0607069.7KRT19, KRT8
3tumor necrosis factor-mediated signaling pathwayGO:0332099.6KRT18, KRT8
4sarcomere organizationGO:0452149.5KRT8, KRT19
5extrinsic apoptotic signaling pathwayGO:0971919.4KRT18, KRT8
6positive regulation of transcription, DNA-templatedGO:0458939.4CDKN2A, NKX2-1, TP63
7viral processGO:0160328.4KRT19, KRT18, KRT7, KRT8

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.7TP63, CDKN2A
2scaffold protein bindingGO:0971109.6KRT8, KRT18
3structural molecule activityGO:0051988.9KRT18, KRT7, KRT8
4protein bindingGO:0055156.9TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19

Products for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet