MCID: PLM038
MIFTS: 44

Pulmonary Large Cell Neuroendocrine Carcinoma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

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MalaCards based summary: Pulmonary Large Cell Neuroendocrine Carcinoma is related to large cell carcinoma and neuroendocrine tumor. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are TP53 network and Signaling mediated by p38-alpha and p38-beta. The compounds griseofulvin and diethyl dithiocarbamate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

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Pulmonary Large Cell Neuroendocrine Carcinoma, Aliases & Descriptions:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:6658
SNOMED-CT57 128628002
NCIt39 C6875

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

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Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma30.7NKX2-1, TP63, KRT7
2neuroendocrine tumor30.5KRT19, NKX2-1, KRT8
3neuroendocrine carcinoma30.5KRT8, KRT19, NKX2-1, TP63, KRT7, KRT18
4lung cancer29.6KRT19, KRT18, TP63, NKX2-1, KRT8, CDKN2A
5large cell neuroendocrine carcinoma11.0
6nephrogenic adenoma10.5KRT7
7leukoplakia10.4KRT8
8small cell carcinoma10.3
9prostatitis10.3
10lambert syndrome10.3
11sex cord-gonadal stromal tumor10.3KRT7, NKX2-1
12bronchiolo-alveolar adenocarcinoma10.3NKX2-1, KRT7
13actinic keratosis10.3TP63
14teratoma10.3NKX2-1, KRT7
15bile duct adenoma10.3KRT19, KRT7
16follicular thyroid carcinoma10.3NKX2-1, KRT19
17bowen syndrome10.2KRT19, KRT7
18barrett's esophagus10.2CDKN2A, KRT7
19merkel cell carcinoma10.2KRT8, NKX2-1
20follicular adenoma10.2KRT19, NKX2-1
21epithelioid sarcoma10.2KRT8, KRT7
22pancreatic ductal carcinoma10.2KRT8, KRT7
23gallbladder cancer10.2KRT8, KRT7
24cirrhosis, noncryptogenic10.2KRT18, KRT8
25cervical intraepithelial neoplasia10.1KRT8, CDKN2A
26alcoholic hepatitis10.1KRT8, KRT18
27hepatoblastoma10.1KRT18, KRT7
28breast ductal carcinoma10.1KRT8, KRT19
29angiosarcoma10.1KRT18, KRT8
30uveal melanoma10.1CDKN2A, KRT8
31autoimmune hepatitis10.1KRT8, KRT18
32tubular adenocarcinoma10.1KRT7, TP63
33primary biliary cirrhosis10.1KRT19, KRT7
34mucoepidermoid carcinoma10.1TP63, KRT7
35viral hepatitis10.1KRT8, KRT18
36abrikosov's tumor10.1NKX2-1, KRT8, KRT7
37hepatitis10.1KRT8, KRT18
38thymoma10.1TP63, NKX2-1
39cork-handlers' disease10.0KRT18, KRT19, NKX2-1
40pleomorphic adenoma10.0TP63, KRT18
41cervical adenocarcinoma10.0KRT8, KRT7, CDKN2A
42breast fibroadenoma10.0KRT8, TP63
43oral cancer10.0KRT19, CDKN2A
44autoimmune thyroiditis10.0TP63, KRT19
45synovial sarcoma10.0KRT19, KRT7, KRT8
46papilloma10.0CDKN2A, TP63
47pancreatitis, chronic10.0KRT18, KRT8
48leiomyosarcoma10.0TP63, KRT8
49thyroid hurthle cell carcinoma10.0KRT19, NKX2-1
50malignant mesothelioma9.9KRT7, CDKN2A, KRT19, NKX2-1

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to pulmonary large cell neuroendocrine carcinoma

Symptoms for Pulmonary Large Cell Neuroendocrine Carcinoma

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Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Large Cell Neuroendocrine Carcinoma

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

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Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

32
Lung, Brain, Prostate, Bronchial epithelium

Animal Models for Pulmonary Large Cell Neuroendocrine Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5TP63, NKX2-1, KRT8, KRT19, CDKN2A
2MP:00020068.5TP63, NKX2-1, KRT19, CDKN2A
3MP:00053798.3VGF, TP63, NKX2-1, KRT19, CDKN2A
4MP:00053808.3TP63, KRT8, KRT18, KRT19, CDKN2A
5MP:00053898.1CDKN2A, KRT19, KRT8, NKX2-1, TP63, VGF
6MP:00053848.0CDKN2A, KRT19, KRT7, NKX2-1, TP63
7MP:00053787.7VGF, TP63, NKX2-1, KRT8, KRT18, KRT19
8MP:00107687.6VGF, TP63, NKX2-1, KRT8, KRT18, KRT19

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

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Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 27)
idTitleAuthorsYear
1
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. (24966991)
2014
2
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. (25364438)
2014
3
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
4
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. (24649189)
2013
5
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. (24023298)
2013
6
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
7
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
8
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. (22359531)
2012
9
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
10
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. (21918393)
2011
11
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. (22977617)
2011
12
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (20398190)
2010
13
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. (20082272)
2009
14
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
15
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
16
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
17
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. (16862075)
2006
18
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
19
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. (15538626)
2005
20
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
21
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
22
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. (15172230)
2004
23
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. (14719055)
2004
24
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
25
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. (11391577)
2001
26
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. (11505281)
2001
27
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

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Expression for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Expression patterns in normal tissues for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TP63, CDKN2A
29.5KRT8, KRT19
38.9KRT8, KRT7, KRT18
48.3KRT7, KRT18, KRT19, KRT8
58.3KRT19, KRT8, KRT7, KRT18

Compounds for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Compounds related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1111.1KRT18, KRT8
2diethyl dithiocarbamate449.8KRT18, KRT8
3doxycycline44 1110.8CDKN2A, KRT18
4gold449.7KRT8, KRT18, CDKN2A
5agar449.6CDKN2A, KRT18, KRT8
6fitc449.6KRT19, KRT18, KRT8
7p005449.6KRT19, TP63
8adriamycin449.5CDKN2A, KRT19, KRT8
9sucrose44 24 1111.5KRT8, KRT18, KRT19
10urea44 24 1111.4LCN1, KRT8, KRT18
11paclitaxel44 50 1111.4KRT8, KRT19, CDKN2A
12actinomycin d449.3KRT8, KRT18, CDKN2A
13oligonucleotide449.3CDKN2A, KRT18, KRT8, NKX2-1
14mucicarmine449.3KRT7, NKX2-1, TP63
15doxorubicin44 50 1111.3TP63, KRT8, KRT18, CDKN2A
16threonine449.2NKX2-1, KRT8, KRT18, CDKN2A
17n-acetylglucosamine449.2KRT8, KRT7, KRT18
18forskolin44 50 1111.2KRT18, KRT8, NKX2-1, VGF
19butyrate449.2CDKN2A, KRT19, KRT18, KRT8
20methanol44 2410.2CDKN2A, KRT7
21chloride449.2KRT19, KRT8, LCN1
22bromodeoxyuridine449.1KRT19, KRT18, KRT8, TP63
23cisplatin44 50 61 1112.1TP63, KRT8, KRT19, CDKN2A
24thymidine44 2410.0KRT19, KRT18, TP63, VGF
25aspartate448.9LCN1, KRT18, KRT19, CDKN2A
26atp44 289.9KRT8, KRT18, KRT19, CDKN2A
27lactate448.9LCN1, KRT8, KRT18, KRT19
28formaldehyde44 249.8NKX2-1, KRT7, KRT18, KRT19
29oxygen44 249.8LCN1, KRT18, KRT19, CDKN2A
30serine448.8NKX2-1, KRT8, KRT18, KRT19, CDKN2A
31retinoid448.7KRT8, KRT7, KRT18, KRT19
32glycogen44 249.7KRT8, KRT7, KRT18, KRT19
33creatinine448.6LCN1, KRT8, KRT18, KRT19, CDKN2A
34steroid448.5TP63, NKX2-1, KRT8, KRT18, KRT19, CDKN2A
35b 723448.4TP63, NKX2-1, KRT8, KRT7, KRT19
36matrigel448.3TP63, KRT8, KRT7, KRT18, KRT19
37lipid448.2LCN1, KRT8, KRT7, KRT18, CDKN2A
38testosterone44 61 24 1111.0TP63, KRT8, KRT7, KRT18, KRT19, CDKN2A
39calcium44 50 24 1110.8TP63, LCN1, KRT8, KRT19, CDKN2A
40iron44 248.8LCN1, KRT8, KRT7, KRT18, KRT19, CDKN2A
41glucose447.8LCN1, KRT8, KRT7, KRT18, KRT19, CDKN2A
42hematoxylin447.7CDKN2A, KRT19, KRT18, KRT7, KRT8, NKX2-1
43paraffin447.7TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
44progesterone44 28 61 24 1111.7TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
45estrogen447.7TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
46retinoic acid44 248.7TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
47tyrosine447.5VGF, TP63, NKX2-1, KRT8, KRT7, KRT18
48vegf447.5VGF, TP63, KRT8, KRT7, KRT18, KRT19

GO Terms for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dystrophin-associated glycoprotein complexGO:0160109.5KRT8, KRT19
2sarcolemmaGO:0423839.5KRT19, KRT8
3costamereGO:0430349.4KRT19, KRT8
4keratin filamentGO:0450958.9KRT18, KRT7, KRT8
5nucleoplasmGO:0056548.6CDKN2A, KRT8, NKX2-1, TP63
6intermediate filamentGO:0058828.5KRT19, KRT18, KRT7, KRT8

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:0972849.8KRT18, KRT8
2cell differentiation involved in embryonic placenta developmentGO:0607069.7KRT19, KRT8
3tumor necrosis factor-mediated signaling pathwayGO:0332099.6KRT18, KRT8
4sarcomere organizationGO:0452149.5KRT8, KRT19
5extrinsic apoptotic signaling pathwayGO:0971919.4KRT18, KRT8
6positive regulation of transcription, DNA-templatedGO:0458939.4CDKN2A, NKX2-1, TP63
7viral processGO:0160328.4KRT19, KRT18, KRT7, KRT8

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.7CDKN2A, TP63
2scaffold protein bindingGO:0971109.6KRT18, KRT8
3structural molecule activityGO:0051988.9KRT18, KRT7, KRT8
4protein bindingGO:0055156.9TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19

Products for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet