MCID: PLM038
MIFTS: 32

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 14
Large Cell Lung Neuroendocrine Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 47 C5672 C6875
SNOMED-CT 64 128628002

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and malignant ovarian mixed epithelial neoplasm, and has symptoms including coughing, dyspnea and fever. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Carboplatin and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate.

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 10.6
2 malignant ovarian mixed epithelial neoplasm 10.4 CHGA SYP
3 ampulla of vater small cell carcinoma 10.4 CHGA SYP
4 spinal cord ependymoma 10.4 CHGA SYP
5 ludwig's angina 10.4 CHGA SYP
6 signet ring cell intrahepatic cholangiocarcinoma 10.4 CHGA SYP
7 childhood choriocarcinoma of the ovary 10.4 CHGA SYP
8 osteoblastoma 10.4 CHGA SYP
9 esophagus adenocarcinoma 10.4 CHGA SYP
10 basophilic carcinoma 10.4 CHGA SYP
11 cystitis cystica 10.4 CHGA SYP
12 small intestine cancer, childhood 10.4 CHGA SYP
13 neurogenic thoracic outlet syndrome 10.4 CHGA SYP
14 aicardi-goutieres syndrome 10.4 CHGA SYP
15 congenital granular cell tumor 10.4 CHGA SYP
16 reticular pattern testicular yolk sac tumor 10.4 CHGA SYP
17 mast cell neoplasm 10.4 CHGA SYP
18 diffuse lipomatosis 10.4 CHGA SYP
19 pleomorphic xanthoastrocytoma 10.4 CHGA SYP
20 thyroid sarcoma 10.4 CHGA SYP
21 sudden sensorineural hearing loss 10.4 CHGA SYP
22 central nervous system hematologic cancer 10.4 CHGA SYP
23 pituitary dwarfism with large sella turcica 10.4 CHGA SYP
24 pneumonia 10.4 CHGA SYP
25 rete ovarii cystadenofibroma 10.4 CHGA SYP
26 pancreatic agenesis 10.4 CHGA SYP
27 nose disease 10.4 CHGA SYP
28 congenital mesoblastic nephroma 10.4 CHGA SYP
29 perianal skin paget's disease 10.4 CHGA SYP
30 cowden syndrome 3 10.4 CHGA SYP
31 hepatorenal syndrome 10.3 CHGA SYP
32 tricuspid valve insufficiency 10.3 CHGA SYP
33 brain stem ependymoma 10.3 CHGA SYP
34 pediatric ependymoma 10.3 CHGA SYP
35 gliofibroma 10.3 CHGA SYP
36 group b strep disease in newborns 10.3 CHGA SYP
37 human t-cell leukemia virus type 1 10.3 CHGA SYP
38 central nervous system melanocytic neoplasm 10.3 CHGA SYP
39 calcific tendinitis 10.3 CHGA SYP
40 bladder cancer, childhood 10.3 CHGA SYP
41 carcinoma of unknown primary site, childhood 10.3 CHGA SYP
42 internal auditory canal lipoma 10.3 CHGA SYP
43 anal canal adenocarcinoma 10.3 CHGA SYP
44 middle ear squamous cell carcinoma 10.3 CHGA SYP
45 large intestine lipoma 10.3 CHGA SYP
46 volkmann contracture 10.3 CHGA SYP
47 caroli disease 10.3 CHGA SYP
48 fallopian tube papillary adenocarcinoma 10.2 CHGA SYP
49 struma ovarii 10.2 CHGA SYP
50 sternum cancer 10.2 CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


coughing, dyspnea, fever, hemoptysis

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 2 41575-94-4 10339178 498142 38904
2
Everolimus Approved Phase 4 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Paclitaxel Approved, Vet_approved Phase 4,Phase 2 33069-62-4 36314
5
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
6 Albumin-Bound Paclitaxel Phase 4,Phase 2
7 Anti-Bacterial Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9 Antifungal Agents Phase 4
10 Anti-Infective Agents Phase 4
11 Antimitotic Agents Phase 4,Phase 1,Phase 2
12 Antineoplastic Agents, Phytogenic Phase 4,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 4
14
Somatostatin Approved Phase 1, Phase 2 38916-34-6, 51110-01-1 53481605
15
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
16
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
17
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
18 Hormone Antagonists Phase 1, Phase 2
19 Hormones Phase 1, Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
21 Dermatologic Agents Phase 1, Phase 2
22 Etoposide phosphate Phase 1, Phase 2
23 Keratolytic Agents Phase 1, Phase 2
24 Podophyllotoxin Phase 1, Phase 2 518-28-5
25 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
26 Topoisomerase Inhibitors Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation Completed NCT01317615 Phase 4 RAD001;Paclitaxel;Carboplatin
2 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
3 uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Recruiting NCT02755675 Phase 2
4 Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer or Metastatic Large Cell Neuroendocrine Non-small Cell Lung Cancer Active, not recruiting NCT01642251 Phase 1, Phase 2 Cisplatin;Etoposide;Veliparib
5 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Not yet recruiting NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
6 Phase I/II Trial of Rhenium 188-P2045 in Small Cell Lung Cancer and Other Advanced Neuroendocrine Carcinomas Withdrawn NCT02030184 Phase 1, Phase 2 Rhenium Re 188-P2045
7 SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma Recruiting NCT02500914 Phase 1 SC-002
8 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

39
Lung, Brain, Prostate, Bronchial Epithelium

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 38)
id Title Authors Year
1
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2017
2
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
3
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
4
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )
2016
5
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
6
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )
2016
7
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )
2016
8
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )
2015
9
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )
2015
10
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )
2015
11
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )
2014
12
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )
2014
13
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )
2013
14
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )
2013
15
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )
2013
16
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )
2013
17
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )
2012
18
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )
2012
19
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )
2012
20
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )
2011
21
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )
2011
22
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. ( 20398190 )
2010
23
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )
2009
24
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )
2009
25
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )
2007
26
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )
2007
27
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )
2006
28
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )
2006
29
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )
2005
30
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )
2005
31
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )
2005
32
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )
2004
33
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )
2004
34
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )
2004
35
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )
2003
36
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )
2001
37
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )
2001
38
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.33 CHGA SYP VGF
2 transport vesicle GO:0030133 8.96 CHGA VGF
3 terminal bouton GO:0043195 8.62 NTRK2 SYP

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuron migration GO:0001764 8.62 CHL1 NTRK2

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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