MCID: PLM038
MIFTS: 33

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 14
Large Cell Lung Neuroendocrine Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 46 C5672 C6875
SNOMED-CT 64 128628002

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and small cell carcinoma, and has symptoms including hemoptysis, fever and dyspnea. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate.

Wikipedia : 72 Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 30.5 CHGA ENO2 SYP
2 small cell carcinoma 29.5 CHGA ENO2 SYP
3 neuroendocrine tumor 29.3 CHGA ENO2 SYP
4 small cell cancer of the lung 29.3 CHGA ENO2 SYP
5 large cell carcinoma 28.2 CHGA ENO2 ROS1 STK11 SYP
6 lung cancer 28.1 CHGA ENO2 ROS1 STK11 SYP
7 ureter small cell carcinoma 10.3 CHGA SYP
8 esophageal neuroendocrine tumor 10.3 CHGA SYP
9 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA SYP
10 adenoma of the pancreas 10.3 CHGA SYP
11 acinar cell cystadenocarcinoma 10.3 CHGA SYP
12 peritoneal serous adenocarcinoma 10.3 CHGA SYP
13 cellular ependymoma 10.3 CHGA SYP
14 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
15 gastrointestinal neuroendocrine tumor 10.3 CHGA SYP
16 chordoid meningioma 10.3 CHGA SYP
17 pancreatic serous cystadenoma 10.3 CHGA SYP
18 conventional angiosarcoma 10.3 CHGA SYP
19 pulmonary sclerosing hemangioma 10.2 CHGA SYP
20 pancreatoblastoma 10.2 CHGA SYP
21 pulmonary blastoma 10.2 CHGA SYP
22 pleomorphic xanthoastrocytoma 10.2 CHGA SYP
23 ureter, cancer of 10.2 CHGA SYP
24 tanycytic ependymoma 10.2 CHGA SYP
25 non-functioning pancreatic endocrine tumor 10.2 CHGA SYP
26 pancreatic cystadenocarcinoma 10.2 CHGA SYP
27 binswanger's disease 10.2 CHGA SYP
28 vaginal benign neoplasm 10.2 CHGA STK11
29 vaginal adenoma 10.2 CHGA STK11
30 vaginal tubulovillous adenoma 10.2 CHGA STK11
31 gastric tubular adenocarcinoma 10.2 CHGA SYP
32 pancreatic gastrinoma 10.2 CHGA SYP
33 breast papillary carcinoma 10.2 CHGA SYP
34 cystadenoma 10.1 CHGA SYP
35 primary pigmented nodular adrenocortical disease 10.1 CHGA SYP
36 cell type benign neoplasm 10.1 CHGA SYP
37 malignant sertoli cell tumor 10.1 ENO2 SYP
38 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
39 cutaneous ganglioneuroma 10.1 ENO2 SYP
40 sensory organ benign neoplasm 10.1 ENO2 SYP
41 middle ear adenoma 10.1 ENO2 SYP
42 pancreatic somatostatinoma 10.1 ENO2 SYP
43 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
44 papillary tumor of the pineal region 10.1 ENO2 SYP
45 orbital cancer 10.0 ENO2 SYP
46 ovarian carcinosarcoma 10.0 ENO2 SYP
47 central nervous system primitive neuroectodermal neoplasm 10.0 ENO2 SYP
48 cerebellum cancer 10.0 ENO2 SYP
49 subependymal glioma 10.0 ENO2 SYP
50 cerebral neuroblastoma 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


hemoptysis, fever, dyspnea, coughing

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
4 Albumin-Bound Paclitaxel Phase 2
5 Topoisomerase Inhibitors Phase 2
6 Etoposide phosphate Phase 2
7 Antimitotic Agents Phase 2
8 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Not yet recruiting NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

38
Lung, Brain, Prostate, Bronchial Epithelium

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 41)
# Title Authors Year
1
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
2
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
3
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
4
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
5
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2017
6
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
7
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )
2016
8
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
9
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )
2016
10
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )
2016
11
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )
2015
12
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )
2015
13
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )
2015
14
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )
2014
15
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )
2014
16
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )
2013
17
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )
2013
18
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )
2013
19
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )
2013
20
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )
2012
21
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )
2012
22
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )
2012
23
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )
2011
24
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )
2011
25
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. ( 20398190 )
2010
26
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )
2009
27
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )
2009
28
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )
2007
29
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )
2007
30
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )
2006
31
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )
2006
32
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )
2005
33
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )
2005
34
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )
2005
35
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )
2004
36
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )
2004
37
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )
2004
38
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )
2003
39
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )
2001
40
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )
2001
41
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell growth GO:0001558 8.62 ROS1 STK11

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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