MCID: PLM038
MIFTS: 43

Pulmonary Large Cell Neuroendocrine Carcinoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell neuroendocrine carcinoma, is related to large cell carcinoma and neuroendocrine carcinoma. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are TP53 network and Signaling mediated by p38-alpha and p38-beta. The compounds griseofulvin and diethyl dithiocarbamate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related mouse phenotypes are reproductive system and digestive/alimentary.

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pulmonary large cell neuroendocrine carcinoma 8 10
large cell neuroendocrine carcinoma 8 60


External Ids:

Disease Ontology8 DOID:6658
SNOMED-CT56 128628002
NCIt39 C6875

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma31.4NKX2-1, KRT7, TP63
2neuroendocrine carcinoma31.4KRT8, KRT7, KRT18, NKX2-1, TP63, KRT19
3adenocarcinoma31.1TP63, KRT7, KRT18, CDKN2A, KRT8, NKX2-1
4bladder carcinoma31.0KRT8, CDKN2A, KRT19, KRT18, TP63
5neuroendocrine tumor30.8NKX2-1, KRT19, KRT8
6lung small cell carcinoma30.7CDKN2A, NKX2-1, KRT19, KRT18, KRT7, KRT8
7lung cancer30.6CDKN2A, NKX2-1, KRT19, KRT18, KRT8, TP63
8lung adenocarcinoma30.5KRT8, TP63, KRT7, KRT19, KRT18, CDKN2A
9squamous cell carcinoma30.5KRT18, KRT19, NKX2-1, CDKN2A, KRT7, KRT8
10adenoma30.4KRT7, KRT19, CDKN2A, KRT18, KRT8, TP63
11non-small cell lung carcinoma30.3KRT18, NKX2-1, TP63, KRT8, KRT19, CDKN2A
12pleomorphic adenoma30.2TP63, KRT18
13papilloma30.2TP63, CDKN2A
14prostate cancer30.2TP63, KRT18, KRT8
15cervical squamous cell carcinoma30.2KRT8, TP63, CDKN2A
16cervical cancer30.2TP63, KRT8, KRT18, CDKN2A
17papillary carcinoma30.2KRT19, TP63, KRT18, KRT7, NKX2-1
18adenosquamous carcinoma30.2KRT8, TP63, KRT7, KRT19, NKX2-1
19lung combined large cell neuroendocrine carcinoma10.6
20small cell carcinoma10.6
21lung large cell carcinoma10.6
22pulmonary neuroendocrine tumor10.6
23breast large cell neuroendocrine carcinoma10.6
24ovarian large-cell neuroendocrine carcinoma10.6
25cervical large cell neuroendocrine carcinoma10.5
26thymus large cell carcinoma10.5
27mucinous adenocarcinoma10.4
28basaloid lung carcinoma10.3
29cervix small cell carcinoma10.3
30spindle cell carcinoma10.3
31lung giant cell carcinoma10.3
32ampulla of vater adenocarcinoma10.3
33bile duct carcinoma10.3
34cervicitis10.3
35colon adenocarcinoma10.3
36gallbladder adenocarcinoma10.3
37thymic carcinoma10.3
38prostatitis10.3
39pleomorphic adenoma carcinoma10.2
40trigonitis10.2
41cushing's syndrome10.2
42pleomorphic carcinoma10.2
43ovarian mucinous adenocarcinoma10.2
44ampulla of vater squamous cell carcinoma10.2
45uterine carcinosarcoma10.2
46ectopic thymus10.2
47gallbladder mucinous carcinoma10.2
48diverticulitis of colon10.2
49adenocarcinoma in situ10.2
50adenosquamous cell lung carcinoma10.2

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to pulmonary large cell neuroendocrine carcinoma

Clinical Features for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Large Cell Neuroendocrine Carcinoma

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

32
Lung, Brain, Prostate

Animal Models for Pulmonary Large Cell Neuroendocrine Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.9KRT19, VGF, CDKN2A
2MP:00053818.2NKX2-1, CDKN2A, KRT19, KRT8, TP63
3MP:00053808.2TP63, KRT8, KRT18, KRT19, CDKN2A
4MP:00053798.0NKX2-1, CDKN2A, VGF, KRT19, TP63
5MP:00053787.5NKX2-1, CDKN2A, VGF, KRT19, KRT18, KRT8
6MP:00107687.1NKX2-1, CDKN2A, VGF, KRT19, KRT18, KRT8

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 30)
idTitleAuthorsYear
1
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
2
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. (24023298)
2013
3
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
4
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
5
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. (22359531)
2012
6
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
7
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. (21918393)
2011
8
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. (22977617)
2011
9
Evaluation of somatostatin receptors in large cell pulmonary neuroendocrine carcinoma with 99mTc-EDDA/HYNIC-TOC scintigraphy. (21383640)
2011
10
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (20398190)
2010
11
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. (19619794)
2009
12
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. (20082272)
2009
13
Small large-cell neuroendocrine carcinoma in a patient with pulmonary emphysema. (19533442)
2009
14
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
15
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
16
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
17
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. (16862075)
2006
18
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
19
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. (15538626)
2005
20
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
21
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
22
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. (15172230)
2004
23
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. (14719055)
2004
24
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
25
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. (11391577)
2001
26
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. (11505281)
2001
27
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994
28
Large cell carcinoma of the lung with neuroendocrine differentiation. A comparison with large cell "undifferentiated" pulmonary tumors. (1317668)
1992
29
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases. (1331003)
1992
30
A pulmonary large cell carcinoma cell line expressing neuroendocrine cell markers and human chorionic gonadotropin alpha-subunit. (1705538)
1991

Genetic Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Expression for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TP63, CDKN2A
29.3KRT8, KRT19
39.3KRT8, KRT7, KRT18
48.5KRT8, KRT7, KRT18, KRT19
58.5KRT19, KRT18, KRT7, KRT8

Compounds for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1111.1KRT8, KRT18
2diethyl dithiocarbamate449.7KRT18, KRT8
3gold449.7KRT8, KRT18, CDKN2A
4mucicarmine449.6NKX2-1, KRT7, TP63
5n-acetylglucosamine449.6KRT8, KRT7, KRT18
6urea44 11 2411.6LCN1, KRT18, KRT8
7agar449.5KRT8, KRT18, CDKN2A
8forskolin44 49 1111.4NKX2-1, VGF, KRT18, KRT8
9fitc449.4KRT19, KRT18, KRT8
10doxorubicin44 49 1111.3CDKN2A, KRT18, KRT8, TP63
11adriamycin449.2KRT8, KRT19, CDKN2A
12oligonucleotide449.1KRT8, KRT18, CDKN2A, NKX2-1
13sucrose44 11 2411.1KRT8, KRT18, KRT19
14bromodeoxyuridine449.0TP63, KRT8, KRT18, KRT19
15chloride448.9LCN1, KRT19, KRT8
16formaldehyde44 249.9NKX2-1, KRT19, KRT18, KRT7
17threonine448.8KRT8, KRT18, CDKN2A, NKX2-1
18retinoid448.8KRT19, KRT18, KRT7, KRT8
19creatinine448.8KRT18, KRT19, CDKN2A, LCN1
20cisplatin44 49 59 1111.8CDKN2A, KRT19, KRT8, TP63
21glycogen44 249.8KRT8, KRT7, KRT18, KRT19
22lactate448.8LCN1, KRT19, KRT18, KRT8
23thymidine44 249.7VGF, KRT19, KRT18, TP63
24aspartate448.6LCN1, CDKN2A, KRT19, KRT18
25lipid448.6LCN1, CDKN2A, KRT18, KRT7, KRT8
26b 723448.5NKX2-1, KRT19, KRT7, KRT8, TP63
27matrigel448.5KRT19, KRT18, KRT7, KRT8, TP63
28glucose448.4CDKN2A, KRT19, KRT18, KRT7, KRT8
29serine448.3CDKN2A, KRT19, KRT18, KRT8, NKX2-1
30steroid448.3NKX2-1, CDKN2A, KRT19, KRT18, KRT8, TP63
31testosterone44 59 11 2411.1CDKN2A, KRT19, KRT18, KRT7, KRT8, TP63
32iron44 249.0LCN1, CDKN2A, KRT19, KRT18, KRT7, KRT8
33hematoxylin447.8TP63, KRT8, KRT7, KRT18, KRT19, CDKN2A
34paraffin447.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
35progesterone44 59 28 11 2411.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
36retinoic acid44 248.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
37tyrosine447.7NKX2-1, VGF, KRT19, KRT18, KRT7, KRT8
38vegf447.6CDKN2A, VGF, KRT19, KRT18, KRT7, KRT8

GO Terms for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.4KRT8, KRT7, KRT18
2dystrophin-associated glycoprotein complexGO:0160109.2KRT8, KRT19
3costamereGO:0430349.0KRT19, KRT8
4intermediate filamentGO:0058828.6KRT8, KRT7, KRT18, KRT19
5nucleoplasmGO:0056548.4NKX2-1, CDKN2A, TTF1, KRT8, TP63
6nucleolusGO:0057308.2TP63, KRT7, KRT18, TTF1, CDKN2A

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-mediated signaling pathwayGO:0332099.8KRT8, KRT18
2cell differentiation involved in embryonic placenta developmentGO:0607069.3KRT8, KRT19
3sarcomere organizationGO:0452149.0KRT8, KRT19
4modulation by virus of host morphology or physiologyGO:0190488.4KRT19, KRT18, KRT7, KRT8

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8KRT8, KRT18
2structural molecule activityGO:0051989.0KRT8, KRT7, KRT18

Products for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet