MCID: PLM038
MIFTS: 36

Pulmonary Large Cell Neuroendocrine Carcinoma malady

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

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33MalaCards
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MalaCards: Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell neuroendocrine carcinoma, is related to large cell carcinoma and neuroendocrine carcinoma. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are TP53 network and Signaling mediated by p38-alpha and p38-beta. The compounds griseofulvin and diethyl dithiocarbamate have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and digestive/alimentary.

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

pulmonary large cell neuroendocrine carcinoma 8 10
large cell neuroendocrine carcinoma 8 61


External Ids:

Disease Ontology8 DOID:6658
SNOMED-CT57 128628002
NCIt40 C6875

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma31.4NKX2-1, KRT7, TP63
2neuroendocrine carcinoma31.4NKX2-1, KRT19, KRT18, KRT7, KRT8, TP63
3adenocarcinoma31.1NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
4bladder carcinoma31.1CDKN2A, KRT19, KRT18, KRT8, TP63
5squamous cell carcinoma30.6NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
6teratoma30.5KRT7, NKX2-1
7thymic carcinoma30.5TP63, KRT7, KRT18, NKX2-1
8basal cell carcinoma30.5TP63, KRT8, KRT7, KRT19
9adenoma30.4NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
10pleomorphic adenoma30.2KRT18, TP63
11papillary carcinoma30.2NKX2-1, KRT19, KRT18, KRT7, TP63
12adenosquamous carcinoma30.2NKX2-1, KRT19, KRT7, KRT8, TP63
13lung combined large cell neuroendocrine carcinoma10.6
14small cell carcinoma10.6
15breast large cell neuroendocrine carcinoma10.6
16ovarian large-cell neuroendocrine carcinoma10.6
17cervical large cell neuroendocrine carcinoma10.5
18thymus large cell carcinoma10.5
19mucinous adenocarcinoma10.4
20basaloid lung carcinoma10.3
21cervix small cell carcinoma10.3
22spindle cell carcinoma10.3
23lung giant cell carcinoma10.3
24bile duct carcinoma10.3
25thymic neuroendocrine carcinoma10.3
26lambert-eaton myasthenic syndrome10.3
27n syndrome10.3
28lambert syndrome10.3
29pleomorphic adenoma carcinoma10.2
30cushing's syndrome10.2
31pleomorphic carcinoma10.2
32ovarian mucinous adenocarcinoma10.2
33uterine carcinosarcoma10.2
34ectopic thymus10.2
35gallbladder mucinous carcinoma10.2
36adenosquamous cell lung carcinoma10.2
37bile duct adenocarcinoma10.2
38uterine disease10.2
39basal cell carcinoma 310.2
40cutaneous neuroendocrine carcinoma10.2
41hemangioma10.0NKX2-1
42leukoplakia10.0KRT8
43hepatitis c10.0KRT18
44pulmonary fibrosis10.0KRT8
45gastritis10.0KRT18
46pulmonary blastoma10.0NKX2-1
47craniopharyngioma10.0KRT8
48ovarian small cell carcinoma10.0TTF1
49actinic keratosis10.0TP63
50benign mesothelioma10.0NKX2-1

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to pulmonary large cell neuroendocrine carcinoma

Clinical Features for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Large Cell Neuroendocrine Carcinoma

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

Animal Models for Pulmonary Large Cell Neuroendocrine Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.9KRT19, VGF, CDKN2A
2MP:00053818.2NKX2-1, CDKN2A, KRT19, KRT8, TP63
3MP:00053808.2TP63, KRT8, KRT18, KRT19, CDKN2A
4MP:00053798.0NKX2-1, CDKN2A, VGF, KRT19, TP63
5MP:00053787.5NKX2-1, CDKN2A, VGF, KRT19, KRT18, KRT8
6MP:00107687.1NKX2-1, CDKN2A, VGF, KRT19, KRT18, KRT8

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
51PubMed
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Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 30)
idTitleAuthorsYear
1
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
2
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. (24023298)
2013
3
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
4
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
5
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. (22359531)
2012
6
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
7
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. (21918393)
2011
8
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. (22977617)
2011
9
Evaluation of somatostatin receptors in large cell pulmonary neuroendocrine carcinoma with 99mTc-EDDA/HYNIC-TOC scintigraphy. (21383640)
2011
10
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (20398190)
2010
11
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. (19619794)
2009
12
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. (20082272)
2009
13
Small large-cell neuroendocrine carcinoma in a patient with pulmonary emphysema. (19533442)
2009
14
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
15
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
16
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
17
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. (16862075)
2006
18
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
19
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. (15538626)
2005
20
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
21
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
22
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. (15172230)
2004
23
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. (14719055)
2004
24
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
25
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. (11391577)
2001
26
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. (11505281)
2001
27
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994
28
Large cell carcinoma of the lung with neuroendocrine differentiation. A comparison with large cell "undifferentiated" pulmonary tumors. (1317668)
1992
29
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases. (1331003)
1992
30
A pulmonary large cell carcinoma cell line expressing neuroendocrine cell markers and human chorionic gonadotropin alpha-subunit. (1705538)
1991

Genetic Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TP63, CDKN2A
29.3KRT8, KRT19
39.3KRT8, KRT7, KRT18
48.5KRT8, KRT7, KRT18, KRT19
58.5KRT19, KRT18, KRT7, KRT8

Compounds for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1griseofulvin45 1111.1KRT8, KRT18
2diethyl dithiocarbamate459.7KRT18, KRT8
3gold459.7KRT8, KRT18, CDKN2A
4mucicarmine459.6NKX2-1, KRT7, TP63
5n-acetylglucosamine459.6KRT8, KRT7, KRT18
6urea45 11 2411.6LCN1, KRT18, KRT8
7agar459.5KRT8, KRT18, CDKN2A
8forskolin45 50 1111.4NKX2-1, VGF, KRT18, KRT8
9fitc459.4KRT19, KRT18, KRT8
10doxorubicin45 50 1111.3CDKN2A, KRT18, KRT8, TP63
11adriamycin459.2KRT8, KRT19, CDKN2A
12oligonucleotide459.1KRT8, KRT18, CDKN2A, NKX2-1
13sucrose45 11 2411.1KRT8, KRT18, KRT19
14bromodeoxyuridine459.0TP63, KRT8, KRT18, KRT19
15chloride458.9LCN1, KRT19, KRT8
16formaldehyde45 249.9NKX2-1, KRT19, KRT18, KRT7
17threonine458.8KRT8, KRT18, CDKN2A, NKX2-1
18retinoid458.8KRT19, KRT18, KRT7, KRT8
19creatinine458.8KRT18, KRT19, CDKN2A, LCN1
20cisplatin45 50 60 1111.8CDKN2A, KRT19, KRT8, TP63
21glycogen45 249.8KRT8, KRT7, KRT18, KRT19
22lactate458.8LCN1, KRT19, KRT18, KRT8
23thymidine45 249.7VGF, KRT19, KRT18, TP63
24aspartate458.6LCN1, CDKN2A, KRT19, KRT18
25lipid458.6LCN1, CDKN2A, KRT18, KRT7, KRT8
26b 723458.5NKX2-1, KRT19, KRT7, KRT8, TP63
27matrigel458.5KRT19, KRT18, KRT7, KRT8, TP63
28glucose458.4CDKN2A, KRT19, KRT18, KRT7, KRT8
29serine458.3CDKN2A, KRT19, KRT18, KRT8, NKX2-1
30steroid458.3NKX2-1, CDKN2A, KRT19, KRT18, KRT8, TP63
31testosterone45 60 11 2411.1CDKN2A, KRT19, KRT18, KRT7, KRT8, TP63
32iron45 249.0LCN1, CDKN2A, KRT19, KRT18, KRT7, KRT8
33hematoxylin457.8TP63, KRT8, KRT7, KRT18, KRT19, CDKN2A
34paraffin457.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
35progesterone45 60 29 11 2411.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
36retinoic acid45 248.8NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
37tyrosine457.7NKX2-1, VGF, KRT19, KRT18, KRT7, KRT8
38vegf457.6CDKN2A, VGF, KRT19, KRT18, KRT7, KRT8

GO Terms for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.4KRT7, KRT8, KRT18
2dystrophin-associated glycoprotein complexGO:0160109.2KRT19, KRT8
3costamereGO:0430349.0KRT8, KRT19
4intermediate filamentGO:0058828.6KRT8, KRT19, KRT18, KRT7
5nucleoplasmGO:0056548.4TP63, KRT8, TTF1, NKX2-1, CDKN2A
6nucleolusGO:0057308.2TP63, KRT7, CDKN2A, TTF1, KRT18

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-mediated signaling pathwayGO:0332099.8KRT8, KRT18
2cell differentiation involved in embryonic placenta developmentGO:0607069.3KRT19, KRT8
3sarcomere organizationGO:0452149.0KRT8, KRT19
4modulation by virus of host morphology or physiologyGO:0190488.4KRT8, KRT19, KRT18, KRT7

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8KRT8, KRT18
2structural molecule activityGO:0051989.0KRT8, KRT7, KRT18

Products for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

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Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet