MCID: PLM038
MIFTS: 44

Pulmonary Large Cell Neuroendocrine Carcinoma malady

Cancer diseases, Neuronal diseases categories

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell neuroendocrine carcinoma, is related to neuroendocrine carcinoma and large cell carcinoma. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are TP53 network and Signaling mediated by p38-alpha and p38-beta. The compounds griseofulvin and diethyl dithiocarbamate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pulmonary large cell neuroendocrine carcinoma 9 11
large cell neuroendocrine carcinoma 63


External Ids:

Disease Ontology9 DOID:6658
SNOMED-CT59 128628002
NCIt41 C6875

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.2TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19
2large cell carcinoma30.7KRT7, NKX2-1, TP63
3neuroendocrine tumor30.5NKX2-1, KRT8, KRT19
4lung cancer30.4TP63, NKX2-1, KRT8, KRT18, KRT19, CDKN2A
5large cell neuroendocrine carcinoma11.0
6small cell carcinoma10.3
7prostatitis10.3
8lambert syndrome10.3
9nephrogenic adenoma10.1KRT7
10leukoplakia10.1KRT8
11sex cord-gonadal stromal tumor10.1KRT7, NKX2-1
12bronchiolo-alveolar adenocarcinoma10.1NKX2-1, KRT7
13actinic keratosis10.1TP63
14teratoma10.1KRT7, NKX2-1
15bile duct adenoma10.1KRT7, KRT19
16follicular thyroid carcinoma10.1NKX2-1, KRT19
17bowen syndrome10.1KRT19, KRT7
18barrett's esophagus10.1CDKN2A, KRT7
19merkel cell carcinoma10.0KRT8, NKX2-1
20follicular adenoma10.0KRT19, NKX2-1
21epithelioid sarcoma10.0KRT7, KRT8
22pancreatic ductal carcinoma10.0KRT7, KRT8
23gallbladder cancer10.0KRT8, KRT7
24cirrhosis, noncryptogenic10.0KRT8, KRT18
25cervical intraepithelial neoplasia10.0CDKN2A, KRT8
26alcoholic hepatitis10.0KRT8, KRT18
27hepatoblastoma10.0KRT18, KRT7
28angiosarcoma10.0KRT8, KRT18
29intraocular melanoma10.0CDKN2A, KRT8
30autoimmune hepatitis10.0KRT8, KRT18
31tubular adenocarcinoma10.0KRT7, TP63
32primary biliary cirrhosis10.0KRT19, KRT7
33mucoepidermoid carcinoma10.0TP63, KRT7
34viral hepatitis10.0KRT8, KRT18
35abrikosov's tumor10.0NKX2-1, KRT8, KRT7
36hepatitis10.0KRT8, KRT18
37thymoma10.0NKX2-1, TP63
38cork-handlers' disease10.0KRT19, KRT18, NKX2-1
39pleomorphic adenoma10.0TP63, KRT18
40cervical adenocarcinoma10.0KRT8, KRT7, CDKN2A
41breast fibroadenoma10.0TP63, KRT8
42oral cancer10.0CDKN2A, KRT19
43autoimmune thyroiditis10.0KRT19, TP63
44synovial sarcoma10.0KRT8, KRT7, KRT19
45papilloma10.0TP63, CDKN2A
46pancreatitis, chronic10.0KRT8, KRT18
47leiomyosarcoma10.0KRT8, TP63
48thyroid cancer10.0KRT19, NKX2-1
49benign mesothelioma10.0CDKN2A, KRT19, KRT7, NKX2-1
50papillary thyroid carcinoma10.0KRT19, NKX2-1, TP63

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to pulmonary large cell neuroendocrine carcinoma

Symptoms for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Large Cell Neuroendocrine Carcinoma

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Search CenterWatch for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

34
Lung, Brain, Prostate

Animal Models for Pulmonary Large Cell Neuroendocrine Carcinoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5TP63, NKX2-1, KRT8, KRT19, CDKN2A
2MP:00020068.5NKX2-1, KRT19, CDKN2A, TP63
3MP:00053798.3VGF, CDKN2A, KRT19, NKX2-1, TP63
4MP:00053808.3KRT18, TP63, CDKN2A, KRT19, KRT8
5MP:00053898.1CDKN2A, KRT19, KRT8, NKX2-1, TP63, VGF
6MP:00053848.0NKX2-1, TP63, KRT7, KRT19, CDKN2A
7MP:00053787.7VGF, TP63, KRT8, KRT18, CDKN2A, NKX2-1
8MP:00107687.6CDKN2A, KRT19, KRT18, KRT8, NKX2-1, TP63

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
53PubMed
See all sources

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 25)
idTitleAuthorsYear
1
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
2
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. (24023298)
2013
3
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
4
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
5
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. (22359531)
2012
6
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
7
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. (21918393)
2011
8
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. (22977617)
2011
9
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (20398190)
2010
10
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. (19619794)
2009
11
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. (20082272)
2009
12
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
13
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
14
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
15
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. (16862075)
2006
16
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
17
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. (15538626)
2005
18
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
19
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
20
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. (15172230)
2004
21
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. (14719055)
2004
22
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
23
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. (11391577)
2001
24
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. (11505281)
2001
25
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section

Expression for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 61Thomson Reuters
See all sources

Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TP63, CDKN2A
29.5KRT8, KRT19
38.9KRT8, KRT7, KRT18
48.3KRT7, KRT18, KRT19, KRT8
58.3KRT19, KRT8, KRT7, KRT18

Compounds for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
See all sources

Compounds related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1griseofulvin46 1211.1KRT18, KRT8
2diethyl dithiocarbamate469.8KRT8, KRT18
3doxycycline46 1210.8CDKN2A, KRT18
4gold469.7KRT8, KRT18, CDKN2A
5agar469.6KRT8, KRT18, CDKN2A
6fitc469.6KRT8, KRT18, KRT19
7p005469.6TP63, KRT19
8adriamycin469.5KRT19, KRT8, CDKN2A
9sucrose46 25 1211.5KRT8, KRT19, KRT18
10urea46 25 1211.4KRT18, LCN1, KRT8
11paclitaxel46 52 1211.4KRT8, KRT19, CDKN2A
12actinomycin d469.3KRT18, CDKN2A, KRT8
13oligonucleotide469.3KRT8, NKX2-1, KRT18, CDKN2A
14mucicarmine469.3TP63, KRT7, NKX2-1
15doxorubicin46 52 1211.3KRT18, CDKN2A, TP63, KRT8
16threonine469.2KRT18, CDKN2A, KRT8, NKX2-1
17n-acetylglucosamine469.2KRT18, KRT8, KRT7
18forskolin46 52 1211.2VGF, KRT8, KRT18, NKX2-1
19butyrate469.2CDKN2A, KRT19, KRT18, KRT8
20methanol46 2510.2KRT7, CDKN2A
21chloride469.2LCN1, KRT19, KRT8
22bromodeoxyuridine469.1KRT19, TP63, KRT8, KRT18
23cisplatin46 52 62 1212.1KRT19, CDKN2A, TP63, KRT8
24thymidine46 2510.0VGF, TP63, KRT18, KRT19
25aspartate468.9CDKN2A, LCN1, KRT18, KRT19
26atp46 309.9KRT8, KRT18, CDKN2A, KRT19
27lactate468.9KRT19, KRT18, LCN1, KRT8
28formaldehyde46 259.8KRT19, KRT7, NKX2-1, KRT18
29oxygen46 259.8LCN1, KRT18, KRT19, CDKN2A
30serine468.8CDKN2A, KRT19, KRT18, KRT8, NKX2-1
31retinoid468.7KRT8, KRT7, KRT18, KRT19
32glycogen46 259.7KRT7, KRT8, KRT18, KRT19
33creatinine468.6KRT19, CDKN2A, KRT18, KRT8, LCN1
34steroid468.5CDKN2A, NKX2-1, TP63, KRT8, KRT18, KRT19
35b 723468.4NKX2-1, KRT8, KRT7, KRT19, TP63
36matrigel468.3KRT19, TP63, KRT7, KRT8, KRT18
37lipid468.2LCN1, KRT18, KRT8, KRT7, CDKN2A
38testosterone46 62 25 1211.0KRT19, KRT18, TP63, CDKN2A, KRT8, KRT7
39calcium46 52 25 1210.8LCN1, TP63, CDKN2A, KRT8, KRT19
40iron46 258.8KRT7, CDKN2A, LCN1, KRT8, KRT18, KRT19
41glucose467.8CDKN2A, KRT19, KRT18, KRT8, LCN1, KRT7
42hematoxylin467.7KRT7, NKX2-1, KRT8, KRT18, KRT19, CDKN2A
43paraffin467.7TP63, KRT18, KRT19, CDKN2A, KRT8, KRT7
44progesterone46 30 62 25 1211.7KRT18, KRT7, KRT8, NKX2-1, TP63, CDKN2A
45estrogen467.7TP63, KRT19, CDKN2A, KRT18, KRT8, NKX2-1
46retinoic acid46 258.7CDKN2A, KRT19, KRT18, KRT7, KRT8, NKX2-1
47tyrosine467.5KRT18, VGF, TP63, NKX2-1, KRT8, KRT19
48vegf467.5KRT7, VGF, TP63, KRT8, KRT18, KRT19

GO Terms for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dystrophin-associated glycoprotein complexGO:0160109.5KRT8, KRT19
2sarcolemmaGO:0423839.5KRT19, KRT8
3costamereGO:0430349.4KRT19, KRT8
4keratin filamentGO:0450958.9KRT8, KRT7, KRT18
5nucleoplasmGO:0056548.6TP63, NKX2-1, KRT8, CDKN2A
6intermediate filamentGO:0058828.5KRT19, KRT18, KRT7, KRT8

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:0972849.8KRT18, KRT8
2cell differentiation involved in embryonic placenta developmentGO:0607069.7KRT19, KRT8
3tumor necrosis factor-mediated signaling pathwayGO:0332099.6KRT18, KRT8
4sarcomere organizationGO:0452149.5KRT8, KRT19
5extrinsic apoptotic signaling pathwayGO:0971919.4KRT18, KRT8
6positive regulation of transcription, DNA-templatedGO:0458939.4CDKN2A, NKX2-1, TP63
7viral processGO:0160328.4KRT19, KRT18, KRT7, KRT8

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.7TP63, CDKN2A
2scaffold protein bindingGO:0971109.6KRT8, KRT18
3structural molecule activityGO:0051988.9KRT18, KRT7, KRT8
4protein bindingGO:0055156.9TP63, NKX2-1, KRT8, KRT7, KRT18, KRT19

Products for genes affiliated with Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet