MCID: PLM039
MIFTS: 33

Pulmonary Neuroendocrine Tumor malady

Cancer diseases, Neuronal diseases categories
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Summaries for Pulmonary Neuroendocrine Tumor

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

MalaCards: Pulmonary Neuroendocrine Tumor is related to neuroendocrine tumor and cushing's syndrome. An important gene associated with Pulmonary Neuroendocrine Tumor is ASCL1 (achaete-scute family bHLH transcription factor 1). The compounds lithium chloride and peptidylglycine have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and thyroid, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

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8Disease Ontology, 40NCIt, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pulmonary neuroendocrine tumor 8


External Ids:

Disease Ontology8 DOID:5410
NCIt40 C5670

Related Diseases for Pulmonary Neuroendocrine Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to pulmonary neuroendocrine tumor

Symptoms for Pulmonary Neuroendocrine Tumor

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Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Neuroendocrine Tumor

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

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Anatomical Context for Pulmonary Neuroendocrine Tumor

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

33
Lung, Lymph node, Thyroid

Animal Models for Pulmonary Neuroendocrine Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1NKX2-1, ASCL1, CHGA, CPE

Publications for Pulmonary Neuroendocrine Tumor

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52PubMed
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Articles related to Pulmonary Neuroendocrine Tumor:

(show all 21)
idTitleAuthorsYear
1
Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study. (23416030)
2013
2
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. (23446117)
2013
3
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. (22391733)
2012
4
Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors. (22924844)
2012
5
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. (21750865)
2011
6
Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors. (21785870)
2011
7
Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]. (20677557)
2010
8
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. (20195926)
2010
9
Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. (19424611)
2009
10
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. (18281538)
2008
11
Immunohistochemical expression of estrogen and progesterone receptors in primary pulmonary neuroendocrine tumors. (19061285)
2008
12
Telomere length, telomerase activity, and expressions of human telomerase mRNA component (hTERC) and human telomerase reverse transcriptase (hTERT) mRNA in pulmonary neuroendocrine tumors. (17060405)
2007
13
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? (16699304)
2006
14
Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. (15712207)
2005
15
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. (15492986)
2004
16
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia as a precursor to pulmonary neuroendocrine tumors. (15136447)
2004
17
hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. (14657947)
2004
18
Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. (15154011)
2004
19
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. (9950155)
1999
20
Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome. (8623922)
1996
21
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. (2866833)
1986

Variations for Pulmonary Neuroendocrine Tumor

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Expression for genes affiliated with Pulmonary Neuroendocrine Tumor

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for genes affiliated with Pulmonary Neuroendocrine Tumor

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Compounds for genes affiliated with Pulmonary Neuroendocrine Tumor

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Pulmonary Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1lithium chloride459.5CHGA, ASCL1
2peptidylglycine459.4CPE, CHGA
3proglucagon459.4CHGA, CPE
4octreotide45 61 29 1112.4GGH, CHGA
5c-peptide459.3CHGA, CPE
6b 723459.3NKX2-1, CHGA
7amide459.2CPE, CHGA
8hematoxylin459.2CHGA, NKX2-1
9dopamine45 29 24 1111.9CHGA, CPE, ASCL1
10formaldehyde45 249.9CHGA, NKX2-1
11forskolin45 51 1110.7NKX2-1, CHGA, CPE
12glutamate458.7GGH, CPE, CHGA
13glucose458.7GGH, CPE, CHGA
14zinc45 249.6CPE, NKX2-1, CHGA
15retinoic acid45 249.3ASCL1, CHGA, NKX2-1

GO Terms for genes affiliated with Pulmonary Neuroendocrine Tumor

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16Gene Ontology
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Cellular components related to Pulmonary Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transport vesicle membraneGO:0306589.1CHGA, CPE

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.4NKX2-1, ASCL1
2cerebral cortex GABAergic interneuron differentiationGO:0218929.1NKX2-1, ASCL1

Products for genes affiliated with Pulmonary Neuroendocrine Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Neuroendocrine Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet