MCID: PLM039
MIFTS: 36

Pulmonary Neuroendocrine Tumor

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

MalaCards integrated aliases for Pulmonary Neuroendocrine Tumor:

Name: Pulmonary Neuroendocrine Tumor 12 14
Neuroendocrine Neoplasm of Lung 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5410
NCIt 46 C5670
SNOMED-CT 64 707594002
UMLS 69 C1334452

Summaries for Pulmonary Neuroendocrine Tumor

MalaCards based summary : Pulmonary Neuroendocrine Tumor, also known as neuroendocrine neoplasm of lung, is related to neuroendocrine tumor and leukemia. An important gene associated with Pulmonary Neuroendocrine Tumor is DLL3 (Delta Like Canonical Notch Ligand 3), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

Related Diseases for Pulmonary Neuroendocrine Tumor

Diseases related to Pulmonary Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.4
2 leukemia 9.7
3 conn's syndrome 9.7
4 acromegaly 9.7
5 thyroiditis 9.7
6 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 9.7

Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to Pulmonary Neuroendocrine Tumor

Symptoms & Phenotypes for Pulmonary Neuroendocrine Tumor

GenomeRNAi Phenotypes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.32 NFIB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 NFIB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.32 BCOR NFIB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.32 BCOR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.32 BCOR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.32 BCOR NFIB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.32 NFIB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.32 BCOR

MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 DLL3 NEUROD1 NFIB ASCL1 BCOR
2 mortality/aging MP:0010768 9.55 DLL3 NEUROD1 NFIB ASCL1 BCOR
3 nervous system MP:0003631 9.35 DLL3 NEUROD1 NFIB ASCL1 BCOR
4 vision/eye MP:0005391 8.92 DLL3 NEUROD1 NFIB ASCL1

Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

Drugs for Pulmonary Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
4
Gemcitabine Approved Phase 2 95058-81-4 60750
5
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
6
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
7
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
8
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
9
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
10
Fluorouracil Approved Phase 2 51-21-8 3385
11
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
12
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
14
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Anti-Infective Agents Phase 1, Phase 2
17 Antifungal Agents Phase 1, Phase 2
18 Immunosuppressive Agents Phase 1, Phase 2
19 Antibiotics, Antitubercular Phase 1, Phase 2
20 Alkylating Agents Phase 2
21 Micronutrients Phase 2
22 Trace Elements Phase 2
23 Hematinics Phase 2
24 Vitamin B Complex Phase 2
25 Vitamins Phase 2
26 Antidotes Phase 2
27 Antimetabolites Phase 2
28 Antimetabolites, Antineoplastic Phase 2
29 Protective Agents Phase 2
30 Antiviral Agents Phase 2
31 Folate Nutraceutical Phase 2
32 Vitamin B9 Nutraceutical Phase 2
33
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
34 Hormone Antagonists Phase 1
35 Hormones Phase 1
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Tolerability Profile of RAD001 Daily in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Unknown status NCT01175096 Phase 1, Phase 2 RAD001 (everolimus, Afinitor®)
2 O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents and Interest of Oxaliplatin in Patients With Unmethylated MGMT NET. Not yet recruiting NCT03217097 Phase 2 Oxaliplatin-based chemotherapy;Alkylating-based chemotherapy
3 Safety and Efficacy of RAD001 in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Completed NCT01324492 Phase 1 RAD001
4 Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs Completed NCT01263353 Phase 1 Pasireotide LAR followed by Pasireotide LAR + Everolimus;Everolimus followed by Pasireotide LAR + Everolimus
5 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

Anatomical Context for Pulmonary Neuroendocrine Tumor

MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

38
Lung, Fetal Lung, Thyroid, Lymph Node

Publications for Pulmonary Neuroendocrine Tumor

Articles related to Pulmonary Neuroendocrine Tumor:

(show all 28)
# Title Authors Year
1
Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus). ( 28190820 )
2017
2
Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors. ( 28621224 )
2017
3
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature. ( 27349224 )
2016
4
Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors. ( 25722034 )
2015
5
Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. ( 26798346 )
2015
6
Carbonic anhydrase II mediates malignant behavior of pulmonary neuroendocrine tumors. ( 25019941 )
2015
7
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. ( 26311731 )
2015
8
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. ( 23446117 )
2013
9
Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study. ( 23416030 )
2013
10
Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors. ( 22924844 )
2012
11
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. ( 22391733 )
2012
12
Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors. ( 21785870 )
2011
13
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. ( 21750865 )
2011
14
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. ( 20195926 )
2010
15
[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]. ( 20677557 )
2010
16
Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. ( 19424611 )
2009
17
Immunohistochemical expression of estrogen and progesterone receptors in primary pulmonary neuroendocrine tumors. ( 19061285 )
2008
18
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. ( 18281538 )
2008
19
Telomere length, telomerase activity, and expressions of human telomerase mRNA component (hTERC) and human telomerase reverse transcriptase (hTERT) mRNA in pulmonary neuroendocrine tumors. ( 17060405 )
2007
20
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? ( 16699304 )
2006
21
Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. ( 15712207 )
2005
22
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia as a precursor to pulmonary neuroendocrine tumors. ( 15136447 )
2004
23
Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. ( 15154011 )
2004
24
hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. ( 14657947 )
2004
25
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. ( 15492986 )
2004
26
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. ( 9950155 )
1999
27
Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome. ( 8623922 )
1996
28
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. ( 2866833 )
1986

Variations for Pulmonary Neuroendocrine Tumor

Expression for Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for Pulmonary Neuroendocrine Tumor

GO Terms for Pulmonary Neuroendocrine Tumor

Cellular components related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.62 ASCL1 NEUROD1

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.76 ASCL1 BCOR NEUROD1 NFIB
2 transcription, DNA-templated GO:0006351 9.71 ASCL1 BCOR NEUROD1 NFIB
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 ASCL1 NEUROD1 NFIB
4 cell differentiation GO:0030154 9.61 ASCL1 DLL3 NEUROD1
5 Notch signaling pathway GO:0007219 9.37 ASCL1 DLL3
6 positive regulation of neuron differentiation GO:0045666 9.32 ASCL1 NEUROD1
7 neuron development GO:0048666 9.26 ASCL1 NEUROD1
8 neurogenesis GO:0022008 9.16 ASCL1 NEUROD1
9 hindbrain development GO:0030902 8.96 NEUROD1 NFIB
10 glial cell differentiation GO:0010001 8.62 ASCL1 NFIB

Molecular functions related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.33 ASCL1 NEUROD1 NFIB
2 protein dimerization activity GO:0046983 9.26 ASCL1 NEUROD1
3 E-box binding GO:0070888 8.96 ASCL1 NEUROD1
4 double-stranded DNA binding GO:0003690 8.8 ASCL1 NEUROD1 NFIB

Sources for Pulmonary Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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