MCID: PLM012
MIFTS: 53

Pulmonary Sarcoidosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sarcoidosis

MalaCards integrated aliases for Pulmonary Sarcoidosis:

Name: Pulmonary Sarcoidosis 38 12 14
Sarcoidosis, Pulmonary 42 69
Sarcoidosis Pulmonary 52
Lung Sarcoidosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13406
ICD10 33 D86.0 D86.2
MeSH 42 D017565
NCIt 47 C34997
SNOMED-CT 64 187230004 24369008
UMLS 69 C0036205

Summaries for Pulmonary Sarcoidosis

MalaCards based summary : Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to pneumoconiosis and pulmonary tuberculosis. An important gene associated with Pulmonary Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iloprost and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Related Diseases for Pulmonary Sarcoidosis

Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
id Related Disease Score Top Affiliating Genes
1 pneumoconiosis 29.9 CCL2 CCL5 IFNG
2 pulmonary tuberculosis 29.8 CCL2 CCL5 IFNG TNF
3 membranoproliferative glomerulonephritis 29.1 ACE IFNG IL2 TNF
4 dysphagia 29.1 CCL5 ICAM1 IFNG IL2RA TNF
5 lymphoma 29.1 ACE IFNG IL2 TNF
6 hemolytic anemia 28.6 CSF2 IL2 IL2RA
7 systemic lupus erythematosus 26.5 CCL2 CCL5 CXCR3 ICAM1 IFNG IL18
8 rheumatoid arthritis 25.9 CCL2 CCL5 CSF2 CXCL5 ICAM1 IFNG
9 sternal cleft 10.8 IFNG TNF
10 smarca4-deficient sarcoma of thorax 10.8 CCL5 TNF
11 mosaic trisomy 1 10.7 IFNG TNF
12 eye accommodation disease 10.7 IFNG IL2RA
13 cytomegalovirus retinitis 10.7 CCL2 ICAM1
14 indian tick typhus 10.7 CCL5 IFNG
15 benign infantile focal epilepsy with midline spikes and wave during sleep 10.7 CCL5 CCR5
16 pneumoconiosis due to talc 10.6 CCL2 TNF
17 crohn's colitis 10.6 IL2RA TNF
18 burn scar 10.6 CXCR3 IFNG TNF
19 spindle cell hemangioma 10.6 ICAM1 IFNG TNF
20 conduct disorder 10.6 ICAM1 IFNG TNF
21 autoimmune retinopathy 10.6 IL2RA TNF
22 antigen-peptide-transporter 2 deficiency 10.6 CCL2 TNF
23 hypervitaminosis d 10.6 CCR5 IFNG TNF
24 diffuse glomerulonephritis 10.6 CCL2 CXCR3 IFNG
25 psychologic dyspareunia 10.6 CCL5 IFNG TNF
26 uveitis 10.5 CCL2 ICAM1 TNF
27 cryptogenic late-onset epileptic spasms 10.5 ACE TNF
28 vulva fibroepithelial polyp 10.5 CCL2 IFNG TNF
29 pulmonary embolism 10.5 CCL2 IFNG TNF
30 cardiac sarcoidosis 10.5 ACE TNF
31 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 10.5 ICAM1 IL2RA
32 scirrhous adenocarcinoma 10.5 IL2 TNF
33 inner ear disease 10.5 CCL5 IFNG TNF
34 cannabis abuse 10.5 CCL5 CXCR3 ICAM1
35 viljoen kallis voges syndrome 10.5 CCL5 CXCR3 ICAM1
36 macroglobulinemia, waldenstrom 1 10.5 CCR5 IFNG TNF
37 alopecia 10.5 CCL2 ICAM1 TNF
38 benign secondary hypertension 10.5 CCL2 CCR5 ICAM1
39 laryngeal papillomatosis 10.5 CSF2 IL2RA
40 liver leiomyoma 10.5 CCR5 TNF
41 ovarian mucinous adenofibroma 10.5 CCL2 CCL5 TNF
42 respiratory system disease 10.5 IFNG IL2RA TNF
43 dermatitis herpetiformis, familial 10.5 CCL2 CCL5 IFNG
44 urethral intrinsic sphincter deficiency 10.5 CCL2 TNF
45 myofascial pain syndrome 10.5 CCL2 CCL5 CXCR3
46 primary systemic mycosis 10.5 CSF2 IFNG TNF
47 cataract 10.5 CSF2 TNF
48 neuromuscular disease 10.5 ACE TNF
49 pasteurellosis 10.5 CSF2 IFNG TNF
50 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.4 CCL2 IL2RA TNF

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to Pulmonary Sarcoidosis

Symptoms & Phenotypes for Pulmonary Sarcoidosis

GenomeRNAi Phenotypes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 IL18 IL2 IL2RA TNF ACE ICAM1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 IL2 IL2RA TNF ACE ICAM1 IL18

MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 CXCR3 ICAM1 IFNG IL18 IL2 IL2RA
2 immune system MP:0005387 10.13 ACE CCL2 CCL5 CCR5 CSF2 CXCR3
3 cardiovascular system MP:0005385 10.11 ACE CCR5 CSF2 CXCR3 ICAM1 IFNG
4 homeostasis/metabolism MP:0005376 10.11 CXCR3 ICAM1 IFNG IL18 IL2 IL2RA
5 mortality/aging MP:0010768 10 IL18 IL2 IL2RA SFTPD TNF ACE
6 digestive/alimentary MP:0005381 9.98 CCR5 ICAM1 IFNG IL18 IL2 IL2RA
7 neoplasm MP:0002006 9.76 ACE CCR5 CSF2 CXCR3 ICAM1 IFNG
8 respiratory system MP:0005388 9.5 IL2 IL2RA SFTPD TNF CSF2 CXCR3
9 vision/eye MP:0005391 9.17 CCR5 ICAM1 IFNG IL18 IL2 IL2RA

Drugs & Therapeutics for Pulmonary Sarcoidosis

Drugs for Pulmonary Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Azathioprine Approved Phase 4 446-86-6 2265
8
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
9
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 942 89594
10
Acetylcholine Approved Phase 4 51-84-3 187
11
Pirfenidone Investigational Phase 4 53179-13-8 40632
12 Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Hormones Phase 4,Phase 3,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
15 Antiemetics Phase 4,Phase 3
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
18 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3
20 glucocorticoids Phase 4,Phase 3,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Platelet Aggregation Inhibitors Phase 4,Phase 2
23 Vasodilator Agents Phase 4,Phase 2,Phase 3
24 Central Nervous System Stimulants Phase 4,Phase 2,Phase 3,Phase 1
25 Dexmethylphenidate Hydrochloride Phase 4
26 Dopamine Agents Phase 4
27 Dopamine Uptake Inhibitors Phase 4
28 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
29 Neurotransmitter Uptake Inhibitors Phase 4
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Methylprednisolone acetate Phase 4
32 Methylprednisolone Hemisuccinate Phase 4
33 Neuroprotective Agents Phase 4
34 Prednisolone acetate Phase 4
35 Prednisolone hemisuccinate Phase 4
36 Prednisolone phosphate Phase 4
37 Protective Agents Phase 4,Phase 2
38 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Adrenocorticotropic Hormone Phase 4
40 beta-endorphin Phase 4
41 Melanocyte-Stimulating Hormones Phase 4
42 Analgesics Phase 4
43 Analgesics, Non-Narcotic Phase 4
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Cholinergic Agents Phase 4,Phase 1,Phase 2
46 Nicotinic Agonists Phase 4,Phase 1,Phase 2
47
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
48
Hydroxychloroquine Approved Phase 3 118-42-3 3652
49
Tadalafil Approved, Investigational Phase 2, Phase 3 171596-29-5 110635
50
Bosentan Approved, Investigational Phase 2, Phase 3 147536-97-8 104865

Interventional clinical trials:

(show top 50) (show all 91)

id Name Status NCT ID Phase Drugs
1 Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension Completed NCT00403650 Phase 4 Iloprost
2 Use of Focalin for Fatigue in Sarcoidosis Completed NCT00361387 Phase 4 d-methylphenidate
3 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Recruiting NCT02188017 Phase 4 Acthar gel
4 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
5 Riociguat for Sarcoidosis Associated Pulmonary Hypertension Recruiting NCT02625558 Phase 4 Riociguat;Placebo
6 Pirfenidone for Progressive Fibrotic Sarcoidosis Recruiting NCT03260556 Phase 4 Pirfenidone;Placebos
7 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Active, not recruiting NCT01830959 Phase 4 Roflumilast;Placebo
8 Study of Nicotine Patches in Patients With Sarcoidosis Suspended NCT00701207 Phase 4 nicotine patch
9 Low-dose Dexamethasone in Newly Diagnosed Pulmonary Sarcoidosis Unknown status NCT01920919 Phase 3 Dexamethasone;Placebo
10 Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension Unknown status NCT00851929 Phase 2, Phase 3 Ambrisentan
11 Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS). Completed NCT02200146 Phase 3 Prednisone;Hydroxychloroquine + Prednisone
12 Antibody Response to Influenza Vaccine in Patients With Sarcoidosis Completed NCT00828828 Phase 3
13 Trial for the Diagnosis of Sarcoidosis Completed NCT00872612 Phase 3
14 Tadalafil for Sarcoidosis Associated Pulmonary Hypertension Completed NCT01324999 Phase 2, Phase 3 Tadalafil
15 Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary Hypertension Completed NCT00581607 Phase 2, Phase 3 Bosentan;Placebo;Bosentan;Placebo
16 A Study of Infliximab in Patients With Sarcoidosis Completed NCT00073437 Phase 3 Infliximab
17 Efficacy and Safety of Influenza Vaccine During Sarcoidosis Completed NCT01687517 Phase 3 Seasonal influenza vaccine available for the 2012-2013 vaccine campaign
18 Use of Armodafinil for Fatigue in Sarcoidosis Completed NCT00555347 Phase 2, Phase 3 Armodafinil;Placebo
19 SARCOTHAL. Thalidomide in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
20 Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Recruiting NCT02824419 Phase 2, Phase 3 Methionine;DOTANOC
21 Mycophenolate for Pulmonary Sarcoidosis Terminated NCT00262132 Phase 3 Mycophenolate
22 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed NCT00001877 Phase 2 Pentoxifylline
23 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2 Atorvastatin
24 Rituximab for Pulmonary Sarcoidosis Completed NCT00855205 Phase 2 Rituximab
25 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
26 Diffuse Fibrotic Lung Disease Completed NCT00000596 Phase 2 prednisone;cyclophosphamide;dapsone
27 Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis Recruiting NCT02024555 Phase 2 Levofloxacin;Ethambutol;Azithromycin;Rifampin;Placebo
28 Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis Recruiting NCT02888080 Phase 2 ACZ885;Placebo
29 Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study Recruiting NCT02265874 Phase 1, Phase 2 Habitrol;Placebo to Habitrol
30 Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Recruiting NCT02036970 Phase 2 Bardoxolone methyl;Placebo
31 SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma Active, not recruiting NCT01362790 Phase 1, Phase 2 Pentostatin;Cyclophosphamide
32 Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability Suspended NCT01615484 Phase 2
33 A Phase 2, Safety, Tolerability, and Efficacy Study of PD 0360324 in Chronic Pulmonary Sarcoidosis Terminated NCT01732211 Phase 2
34 Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis Terminated NCT00926627 Phase 2 bosentan;placebo
35 Safety Study of Abatacept to Treat Refractory Sarcoidosis Terminated NCT00739960 Phase 2 Abatacept
36 Trial of Adalimumab in Progressive Sarcoidosis Terminated NCT00311246 Phase 2 Adalimumab
37 Evaluation of the Diagnostic Utility of INS316 in Patients With Interstitial Lung Diseases (01-701) Terminated NCT01381666 Phase 2 INS316 solution for inhalation;hypertonic saline 3% sodium chloride solution
38 Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis Completed NCT01169038 Phase 1 levaquin; ethambutol; rifampin and azithromycin.
39 A Phase I Trial of SS1 (dsFv) PE38 With Paclitaxel, Carboplatin, and Bevacizumab in Subjects With Unresectable Non-Small Cell Lung Adenocarcinoma Completed NCT01051934 Phase 1 SS1 (dsFv) PE38;Paclitaxel;Carboplatin;Bevacizumab
40 Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis Terminated NCT01440192 Phase 1
41 Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study Unknown status NCT01384123
42 A Trial to Compare Two Methods of Obtaining Tissue for Diagnosis of Sarcoidosis Namely the Conventional Method or the Ultrasound Guided Method Unknown status NCT02472808
43 Validation of a Non-invasive Diagnostic Method for Sarcoidosis Using Exhaled Breath Unknown status NCT02361281
44 Pulmonary Rehabilitation in Interstitial Lung Disease Unknown status NCT00168285
45 Database of Interstitial Lung Diseases Unknown status NCT00267800
46 The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis Unknown status NCT01714934
47 The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis Completed NCT01587001 Placebo
48 Sarcoidosis-associated Pulmonary Hypertension Completed NCT01139710
49 The Occurence of Inflammation and Oxidative Stress in Lung Diseases Completed NCT00512967
50 Pathogen Specific Immunity in Patients With Sarcoidosis Completed NCT00217789

Search NIH Clinical Center for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived cells PMIDs: 22469567

Cochrane evidence based reviews: sarcoidosis, pulmonary

Genetic Tests for Pulmonary Sarcoidosis

Anatomical Context for Pulmonary Sarcoidosis

MalaCards organs/tissues related to Pulmonary Sarcoidosis:

39
Lung, T Cells, Lymph Node, Testes, Monocytes, Skin, Eye

Publications for Pulmonary Sarcoidosis

Articles related to Pulmonary Sarcoidosis:

(show top 50) (show all 616)
id Title Authors Year
1
Pulmonary sarcoidosis mimicking tuberculosis: Importance of the galaxy sign on thoracic computed tomography. ( 28863878 )
2017
2
Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review. ( 28671172 )
2017
3
Pulmonary Sarcoidosis. ( 28750459 )
2017
4
Pulmonary Sarcoidosis That Developed During the Treatment of a Patient With Crohn Disease by Using Infliximab. ( 28503520 )
2017
5
Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ( 27826889 )
2017
6
Living Kidney Donation From a Donor With Pulmonary Sarcoidosis: AA Case Report and Review of the Literature. ( 28583552 )
2017
7
Pulmonary Sarcoidosis Presenting with Thin-walled Small Cysts. ( 28420852 )
2017
8
Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept. ( 28124746 )
2017
9
Repository corticotropin for Chronic Pulmonary Sarcoidosis. ( 28353116 )
2017
10
Resolution rate of pulmonary sarcoidosis and its related factors in a Japanese population. ( 28712145 )
2017
11
Ulcerating Nodules within Tattoos Revealing Pulmonary Sarcoidosis. ( 28881429 )
2017
12
Clinical Features of Pulmonary Sarcoidosis Complicated by Lung Cancer. ( 28768963 )
2017
13
Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ( 28229082 )
2017
14
Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis. ( 27682024 )
2017
15
Predictors of Mortality in Pulmonary Sarcoidosis. ( 28728933 )
2017
16
Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma. ( 28737580 )
2017
17
[Analysis of an association of TNF -308G>A polymorphism with a risk for pulmonary sarcoidosis in the Russian population of the Republic of Karelia]. ( 28378732 )
2017
18
Strategies for identifying pulmonary sarcoidosis patients at risk for severe or chronic disease. ( 28076979 )
2017
19
Pulmonary sarcoidosis: an update. ( 27766929 )
2017
20
99mTc-anti-TNF-I+ antibody for the imaging of disease activity in pulmonary sarcoidosis. ( 26797030 )
2016
21
Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis. ( 27575817 )
2016
22
Pulmonary metastases from low grade sarcoma in a patient with pulmonary sarcoidosis. Sarcoidosis or sarcoid-like reaction? ( 27537721 )
2016
23
Refractory pulmonary sarcoidosis - proposal of a definition and recommendations for the diagnostic and therapeutic approach. ( 26973429 )
2016
24
Altered miRNA expression in pulmonary sarcoidosis. ( 26768132 )
2016
25
Pulmonary hypertension complicating pulmonary sarcoidosis. ( 27194118 )
2016
26
Nephrology: Instructive case haemorrhagic cystitis due to BK virus in an adult with cardiac & pulmonary sarcoidosis. ( 27546780 )
2016
27
Effects of radiological extent on neutrophil/lymphocyte ratio in pulmonary sarcoidosis. ( 26957274 )
2016
28
Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review. ( 27067783 )
2016
29
Clinical Features of Ocular Sarcoidosis in Patients with Biopsy-proven Pulmonary Sarcoidosis in Serbia. ( 27191355 )
2016
30
The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis. ( 26831541 )
2016
31
Clinical significance of the "galaxy sign" in patients with pulmonary sarcoidosis in a Japanese single-center cohort. ( 27758990 )
2016
32
Pulmonary sarcoidosis induced by the anti-PD-1 monoclonal antibody pembrolizumab or post-immunotherapy granulomatous reaction: which is more appropriate terminology? ( 27143637 )
2016
33
CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis. ( 27701118 )
2016
34
Functional TLR9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. ( 27390897 )
2016
35
Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ( 27401080 )
2016
36
Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. ( 27055833 )
2016
37
Spontaneous resolution of a tumor like pulmonary sarcoidosis. ( 27758997 )
2016
38
The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without LAPfgren's Syndrome. ( 28050119 )
2016
39
Pulmonary sarcoidosis or post-immunotherapy granulomatous reaction induced by the anti-PD-1 monoclonal antibody pembrolizumab: the terminology is not the key point. ( 27551050 )
2016
40
T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis. ( 26585430 )
2016
41
Fatigue and health-related quality of life in patients with pulmonary sarcoidosis treated by oral Corticosteroids. ( 27537714 )
2016
42
Dementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis. ( 28127435 )
2016
43
Treatment indications for pulmonary sarcoidosis. ( 27055843 )
2016
44
Clinical and radiological features of extra-pulmonary sarcoidosis: a pictorial essay. ( 27222055 )
2016
45
Clinical management of pulmonary sarcoidosis. ( 26959110 )
2016
46
Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules. ( 27566455 )
2016
47
Pulmonary sarcoidosis: calcification within the galaxy sign. ( 27979849 )
2016
48
Exhaled nitric oxide is not increased in pulmonary sarcoidosis. ( 27055834 )
2016
49
Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis. ( 27688795 )
2016
50
Assessment of right ventricular systolic and diastolic parameters in pulmonary sarcoidosis. ( 26912008 )
2016

Variations for Pulmonary Sarcoidosis

Expression for Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for Pulmonary Sarcoidosis

Pathways related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
2
Show member pathways
13.84 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
3
Show member pathways
13.6 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
4
Show member pathways
13.53 CCL2 CCL5 ICAM1 IFNG IL18 IL2
5
Show member pathways
13.36 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
6
Show member pathways
13.29 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
7
Show member pathways
13.17 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
8
Show member pathways
12.9 ACE CCL2 CCL5 IFNG IL2 SFTPD
9
Show member pathways
12.86 CCL2 CCL5 CCR5 CXCL5 CXCR3
10
Show member pathways
12.85 ICAM1 IFNG IL2 IL2RA TNF
11
Show member pathways
12.75 CCL2 CCL5 ICAM1 IFNG IL18 IL2
12
Show member pathways
12.65 IFNG IL18 IL2 IL2RA TNF
13
Show member pathways
12.63 IFNG IL18 IL2 IL2RA TNF
14
Show member pathways
12.62 CCL2 IFNG IL18 IL2 TNF
15 12.59 CCL2 CCL5 IFNG IL2 IL2RA TNF
16
Show member pathways
12.55 CSF2 ICAM1 IFNG IL2 TNF
17
Show member pathways
12.47 CCR5 CSF2 IFNG IL2 TNF
18 12.46 CSF2 ICAM1 IL2 IL2RA TNF
19
Show member pathways
12.38 CCL2 CSF2 CXCL5 IFNG TNF
20
Show member pathways
12.24 CSF2 IFNG IL2 IL2RA
21
Show member pathways
12.19 IFNG IL18 IL2 TNF
22 12.13 CCL2 ICAM1 IFNG TNF
23 12.09 CCL2 ICAM1 IFNG IL2 TNF
24
Show member pathways
12.09 CCL2 CCL5 CCR5 CXCL5 CXCR3
25 12.06 CSF2 IFNG IL2 IL2RA TNF
26
Show member pathways
12.04 CCR5 IFNG IL18 IL2 IL2RA
27
Show member pathways
12.03 IFNG IL2 IL2RA
28 12.02 CCL2 ICAM1 IL18 TNF
29
Show member pathways
11.99 IFNG IL18 IL2 TNF
30 11.94 CCR5 IFNG IL2 IL2RA
31 11.9 CCL2 ICAM1 TNF
32 11.88 CSF2 IL2RA TNF
33 11.88 CSF2 IFNG TNF
34 11.88 CCL2 CCL5 CSF2 CXCL5 ICAM1 TNF
35 11.87 CSF2 ICAM1 IFNG IL2
36 11.83 CSF2 IFNG IL18
37 11.82 CSF2 IFNG IL2 TNF
38
Show member pathways
11.82 CSF2 IFNG IL2 IL2RA TNF
39 11.73 ICAM1 IL2RA TNF
40 11.73 CCL2 CCL5 CSF2 TNF
41
Show member pathways
11.71 IFNG IL2 IL2RA TNF
42
Show member pathways
11.69 CSF2 ICAM1 IFNG IL2 TNF
43 11.6 CCL2 IFNG IL18 TNF
44 11.59 IFNG IL2 TNF
45 11.56 IFNG IL2 TNF
46 11.55 IFNG IL2 IL2RA
47 11.54 CXCR3 IFNG IL18 IL2 IL2RA TNF
48 11.52 CCL2 ICAM1 IFNG IL18 TNF
49 11.43 ICAM1 IFNG IL18 TNF
50 11.38 IFNG IL2 IL2RA

GO Terms for Pulmonary Sarcoidosis

Cellular components related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ACE CCL2 CCL5 CSF2 CXCL5 IFNG
2 extracellular space GO:0005615 9.7 ACE CCL2 CCL5 CSF2 CXCL5 ICAM1
3 cell surface GO:0009986 9.65 CCR5 CXCR3 ICAM1 IL2RA TNF
4 external side of plasma membrane GO:0009897 9.17 ACE CCR5 CXCR3 ICAM1 IFNG IL2RA

Biological processes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.96 CCL5 CCR5 CXCL5 IL18 IL2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL2 CCL5 ICAM1 TNF
3 cell surface receptor signaling pathway GO:0007166 9.92 CCL2 CCR5 CXCR3 IFNG IL2RA
4 positive regulation of gene expression GO:0010628 9.89 CSF2 IFNG TNF
5 cellular response to tumor necrosis factor GO:0071356 9.89 CCL2 CCL5 ICAM1
6 response to ethanol GO:0045471 9.88 CCL2 ICAM1 IL2
7 response to virus GO:0009615 9.87 CCL5 IFNG TNF
8 cellular response to interleukin-1 GO:0071347 9.85 CCL2 CCL5 ICAM1
9 chemotaxis GO:0006935 9.85 CCL2 CCL5 CCR5 CXCL5 CXCR3
10 cell chemotaxis GO:0060326 9.84 CCL2 CCL5 CXCL5
11 regulation of insulin secretion GO:0050796 9.84 CCL5 IFNG TNF
12 neutrophil chemotaxis GO:0030593 9.83 CCL2 CCL5 IFNG
13 cellular response to interferon-gamma GO:0071346 9.83 CCL2 CCL5 ICAM1
14 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 CCL5 IL18 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 CCL5 IL18 TNF
16 humoral immune response GO:0006959 9.8 CCL2 IFNG TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 ICAM1 IFNG TNF
18 positive regulation of T cell proliferation GO:0042102 9.78 CCL5 IFNG IL2 IL2RA
19 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL2 TNF
20 chemokine-mediated signaling pathway GO:0070098 9.77 CCL2 CCL5 CCR5 CXCL5 CXCR3
21 inflammatory response GO:0006954 9.76 CCL2 CCL5 CCR5 CXCL5 CXCR3 IL18
22 protein kinase B signaling GO:0043491 9.75 CCL2 CCL5 TNF
23 positive regulation of activated T cell proliferation GO:0042104 9.74 IL18 IL2 IL2RA
24 positive regulation of cell adhesion GO:0045785 9.73 CCL2 CCL5 IFNG TNF
25 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CCR5 CSF2 ICAM1 IFNG TNF
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.72 IL18 TNF
27 positive regulation of osteoclast differentiation GO:0045672 9.72 IFNG TNF
28 positive regulation of T cell differentiation GO:0045582 9.72 IL2 IL2RA
29 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CCL5 CSF2 IFNG IL18 IL2
30 positive regulation of monocyte chemotaxis GO:0090026 9.71 CCL2 CCL5
31 cellular response to interleukin-6 GO:0071354 9.71 CCL2 ICAM1
32 dendritic cell chemotaxis GO:0002407 9.71 CCL5 CCR5
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 CCL5 IL18 TNF
34 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.7 CSF2 IL18
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IFNG TNF
36 negative regulation of growth of symbiont in host GO:0044130 9.7 IFNG TNF
37 positive regulation of macrophage chemotaxis GO:0010759 9.69 CCL2 CCL5
38 positive regulation of interleukin-17 production GO:0032740 9.69 IL18 IL2
39 positive regulation of podosome assembly GO:0071803 9.68 CSF2 TNF
40 positive regulation of isotype switching to IgG isotypes GO:0048304 9.68 IFNG IL2
41 neutrophil mediated immunity GO:0002446 9.68 ACE CXCL5
42 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IFNG TNF
43 macrophage chemotaxis GO:0048246 9.67 CCL2 CCL5 SFTPD
44 receptor-mediated virion attachment to host cell GO:0046813 9.65 ACE ICAM1
45 positive regulation of cellular extravasation GO:0002693 9.65 CCL2 ICAM1
46 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 ICAM1 TNF
47 negative regulation of lymphocyte proliferation GO:0050672 9.64 IL2 IL2RA
48 positive regulation of tissue remodeling GO:0034105 9.63 IL18 IL2
49 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IFNG
50 regulation of T cell homeostatic proliferation GO:0046013 9.59 IL2 IL2RA

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 CSF2 IL2 IL2RA
2 chemokine receptor activity GO:0004950 9.26 CCR5 CXCR3
3 cytokine activity GO:0005125 9.23 CCL2 CCL5 CSF2 CXCL5 IFNG IL18
4 chemokine activity GO:0008009 9.13 CCL2 CCL5 CXCL5

Sources for Pulmonary Sarcoidosis

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10 dbSNP
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16 ExPASy
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