MCID: PLM012
MIFTS: 55

Pulmonary Sarcoidosis malady

Immune diseases, Respiratory diseases categories

Summaries for Pulmonary Sarcoidosis

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MalaCards: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to sarcoidosis and pulmonary fibrosis. An important gene associated with Pulmonary Sarcoidosis is IFNA10 (interferon, alpha 10), and among its related pathways are Cytokine Network and Allograft rejection. The compounds endotoxin and tarc have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Pulmonary Sarcoidosis

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8Disease Ontology, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Respiratory diseases


Aliases & Descriptions:

pulmonary sarcoidosis 8 30
sarcoidosis, pulmonary 60
sarcoidosis pulmonary 44
lung sarcoidosis 8


External Ids:

Disease Ontology8 DOID:13406
NCIt39 C34997
SNOMED-CT56 187230004, 24369008
MeSH34 D017565
ICD1025 D86.0, D86.2

Related Diseases for Pulmonary Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.9IL9, CCL3, CXCL9, CXCR6, CXCL5, CXCR3
2pulmonary fibrosis30.7CXCR3, SFTPD, CCL3
3tuberculosis30.6CCL3, SFTPD, CD69, CXCR3, CXCL9
4idiopathic pulmonary fibrosis30.6CCL3, SFTPD, SCGB1A1, CXCR3, CXCL5, CXCL9
5pneumonia30.4CCL3, SFTPD, SCGB1A1, CXCL5, MMP12
6systemic lupus erythematosus30.4CCL3, CD69, CD27, CXCR3
7lung cancer30.4SFTPD, SCGB1A1, CXCR3, IL9, MMP12
8arthritis30.3CCL3, CD69, CXCR3, CXCL5, CXCL9, MMP12
9glomerulonephritis30.3CXCL9, SCGB1A1
10cystic fibrosis30.1IL9, SCGB1A1, SFTPD
11rheumatoid arthritis30.1CCL3, SFTPD, GZMA, CD69, CD27, CXCR3
12multiple sclerosis30.1CCL3, SCGB1A1, CD69, CD27, CXCR3, CXCL9
13breast cancer30.1CCL3, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
14bronchiolitis29.9CCL3
15interstitial lung disease29.9SFTPD
16psoriasis29.9CD69, CXCR3, CXCL9
17extrinsic allergic alveolitis29.9CCL3, SFTPD, CXCR3
18influenza29.9CXCL9, CXCR3, CD27, CD69, SFTPD
19leukemia29.9CCL3, GZMA, SCGB1A1, CD27, CXCR3, IL9
20pulmonary emphysema29.9MMP12, SFTPD
21adenocarcinoma29.9MMP12, SCGB1A1, SFTPD
22bronchiolitis obliterans29.9CXCR3, SCGB1A1
23pulmonary tuberculosis10.4
24cardiac sarcoidosis10.3
25lupus erythematosus10.3
26ankylosing spondylitis10.2
27spondylitis10.2
28focal segmental glomerulosclerosis10.1
29membranoproliferative glomerulonephritis10.1
30skin sarcoidosis10.1
31focal glomerulosclerosis10.1
32amyloidosis10.1
33hypertension10.1
34mediastinitis10.1
35hepatitis b10.0IFNA17
36hepatitis c10.0IFNA17, CXCR3, CXCR6
37dermatitis10.0CXCL9, CXCR3
38inflammatory bowel disease10.0CCL25
39endometriosis10.0CXCL5, CD69
40eosinophilia10.0CD69, IL9
41uveitis10.0CD69, CXCR3, CXCL9, IL9
42multiple myeloma10.0CCL3
43graves' disease10.0CXCR3, CD69
44nephritis10.0CXCR3, SCGB1A1
45pulmonary disease, chronic obstructive10.0CCL3, SFTPD, SCGB1A1, CXCR3, IL9, MMP12
46atherosclerosis10.0CCL15, CXCR3, CXCR6, CXCL9, MMP12
47allergic asthma10.0CCL3, SFTPD, SCGB1A1, CD69, IL9
48myeloma10.0CCL3, CD27
49melanoma10.0CCL3, GZMA, CD27, CXCR3, CXCL5, CXCL9
50osteoarthritis10.0CCL3, GZMA, CXCR3, CXCL5, MMP12

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Clinical Features for Pulmonary Sarcoidosis

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Drugs & Therapeutics for Pulmonary Sarcoidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Search CenterWatch for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

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Anatomical Context for Pulmonary Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Sarcoidosis:

32
Lung, T cells, Testes, Lymph node, Monocytes, Skin, Breast, Myeloid, Endothelial, Heart, Spleen, Eye, Liver, Bone, Nk cells

Animal Models for Pulmonary Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.3CCL3, SFTPD, GZMA, CD69, CD27, IL9
2MP:000538710.0MMP12, CCL25, CCL3, SFTPD, GZMA, SCGB1A1

Publications for Pulmonary Sarcoidosis

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50PubMed
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Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Elevated pulmonary arterial systolic pressure in patients with sarcoidosis: prevalence and risk factors. (23229755)
2013
2
Inflammatory markers and pulmonary granuloma infiltration in sarcoidosis. (24372709)
2013
3
Predictive value of serum markers for pulmonary involvement in ocular sarcoidosis. (23910667)
2013
4
Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. (23940611)
2013
5
Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis. (23857158)
2013
6
Severity of pulmonary involvement and (18)F-FDG PET activity in sarcoidosis. (23261309)
2013
7
Pulmonary sarcoidosis mimicking multiple pulmonary metastases. (22662647)
2012
8
Pulmonary hyalinizing granuloma with associated elevation in serum and tissue IgG4 occurring in a patient with a history of sarcoidosis. (22498827)
2012
9
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
10
Pulmonary sarcoidosis: the 'Great Pretender'. (20599067)
2010
11
Impaired left ventricular systolic and diastolic functions in patients with early grade pulmonary sarcoidosis. (20513700)
2010
12
The role of atopy in the clinical course of pulmonary sarcoidosis in the Japanese population. (20615325)
2010
13
Pulmonary sarcoidosis in an HIV/human T-cell lymphotrophic viruses I/II coinfected patient. (21287908)
2010
14
Chitotriosidase activity in sarcoidosis and some other pulmonary diseases. (19347743)
2009
15
Pulmonary sarcoidosis with pulmonary hypertension, fossa ovalis aneurysm and interatrial shunt. (17567843)
2008
16
Cutaneous and pulmonary sarcoidosis in a patient with HIV after highly active antiretroviral therapy. (17214725)
2007
17
Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma). (17937104)
2006
18
Progressive pulmonary sarcoidosis--a fibroproliferative process potentially triggered by EGR-1 and IL-6. (16933469)
2006
19
Pulmonary sarcoidosis associated with psoriasis vulgaris: coincidental occurrence or causal association? Case report. (17166281)
2006
20
Pulmonary sarcoidosis: comparison of findings of inspiratory and expiratory high-resolution CT and pulmonary function tests between smokers and nonsmokers. (16037502)
2005
21
Membrane and capillary blood components of diffusion capacity of the lung for carbon monoxide in pulmonary sarcoidosis: relation to exercise gas exchange. (15189922)
2004
22
Pulmonary sarcoidosis. (15331189)
2004
23
Human leukocyte antigen-DR alleles influence the clinical course of pulmonary sarcoidosis in Asian Indians. (12600814)
2003
24
CC chemokine receptor 5 (CCR5) mRNA expression in pulmonary sarcoidosis. (11803051)
2002
25
Increased production of matrix metalloproteinase-2 in alveolar macrophages and regulation by interleukin-10 in patients with acute pulmonary sarcoidosis. (11792075)
2002
26
Immune restoration syndrome manifested by pulmonary sarcoidosis. (11717100)
2001
27
KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (11694811)
2001
28
Ace gene I/D polymorphism and sarcoidosis pulmonary disease severity. (11463587)
2001
29
The prognosis of pulmonary sarcoidosis in Finland and Hokkaido, Japan. A comparative five-year study of biopsy-proven cases. (10957764)
2000
30
Increased levels of interleukin-18 in patients with pulmonary sarcoidosis. (11069843)
2000
31
Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis. (10712327)
2000
32
Pulmonary sarcoidosis: presentation as bilateral spontaneous hydropneumothorax and pulmonary infiltrates. (10832948)
2000
33
Pulmonary sarcoidosis in a south Indian hospital: clinical and lung function profile. (10534939)
1999
34
Malignant neoplasms in pulmonary sarcoidosis. (9797771)
1998
35
Expression of insulin-like growth factor binding proteins in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. (9698597)
1998
36
Clinical findings in 715 patients with newly detected pulmonary sarcoidosis--results of a cooperative study in former West Germany and Switzerland. WATL Study Group. Wissenschaftliche Arbeitsgemeinschaft fA1r die Therapie von Lungenkrankheitan. (9789897)
1998
37
Glucocorticosteroids and pulmonary sarcoidosis. (8779121)
1996
38
Pulmonary sarcoidosis coexisting with systemic lupus erythematosus. (8614766)
1996
39
Pulmonary sarcoidosis: population differences and pathophysiology. (7481954)
1995
40
Cytokines in the bronchoalveolar lavage fluid of patients with active pulmonary sarcoidosis. (7599865)
1995
41
Association of histologically proven rheumatoid arthritis with pulmonary sarcoidosis. (7789498)
1995
42
Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. (8118632)
1994
43
A case of pulmonary sarcoidosis associated with severe hypercalcemia]. (7958099)
1994
44
Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis. (1731582)
1992
45
Lavage versus serum measurements of lysozyme, angiotensin converting enzyme and other inflammatory markers in pulmonary sarcoidosis. (1965306)
1990
46
Immunological features of lung lavage cells from patients with primary biliary cirrhosis may reflect those seen in pulmonary sarcoidosis. (2311980)
1990
47
Pulmonary sarcoidosis: evaluation with high-resolution CT. (2748828)
1989
48
Relationship between inflammatory processes and gas exchanges in pulmonary sarcoidosis. (2670466)
1989
49
Pulmonary sarcoidosis: do cellular and immunochemical lung parameters exist that would separate subgroups of patients for prognosis? (2657919)
1989
50
Mycetoma formation in cavitary pulmonary sarcoidosis. (5439429)
1970

Genetic Variations for Pulmonary Sarcoidosis

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Expression for genes affiliated with Pulmonary Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IFNA10, IFNA17, IL9
2
Hide members
10.4IL9, IFNA17, IFNA10, CCL25
3
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10.4CXCL9, IFNA17, IFNA10, CCL3
4
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10.4CCL25, CCL15, CCL23, CCL3, IFNA10, IFNA17
510.4CCL25, CCL3, CXCR3, CXCL5, CXCR6, CXCL9
6
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10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
7
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10.3CCL25, IL9, CXCL9, CXCR6, CXCL5, CXCR3
8
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10.3CXCL9, CXCR6, CXCL5, CXCR3, CCL3, CCL23
9
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
10
Hide members
10.3CCL25, CCL23, CCL3, GZMA, CXCR3, CXCL5
11
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
12
Hide members
10.3IL9, CCL25, CCL15, CCL23, CCL3, IFNA10

Compounds for genes affiliated with Pulmonary Sarcoidosis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.8SCGB1A1, CXCR3, CXCL5
2tarc4410.8CCL3, CXCR3, CXCL5, CXCL9, IL9
3rantes4410.8IL9, CXCR6, CXCL5, CXCR3, GZMA, CCL3
4ccl444 2811.7CCL15, CCL3, CXCR3, CXCL5, CXCL9
5ccl344 2811.7CCL15, CCL23, CCL3, CXCR3, CXCL5, CXCL9
6dexamethasone44 49 28 1113.7MMP12, CXCL9, GREM1, SFTPD
7allergens4410.7IL9, CXCR3, CD69, SFTPD
8groalpha4410.7CCL3, CXCR3, CXCL5, CXCL9
9ena 784410.7CXCL5, CXCL9
10histamine44 28 2412.7CCL3, SFTPD, CXCR3, CXCL9, IL9
11nitric oxide44 11 2412.7CCL3, SFTPD, SCGB1A1, CD69, CXCR3, CXCL5
12ionomycin4410.7CCL3, GZMA, CD69, CXCR6, CXCL9, IL9
13oxygen44 2411.7MMP12, SCGB1A1, GZMA, SFTPD, CCL3
14fmlp4410.6CXCL5, CXCR3, CD69, CCL3
15il 104410.6CXCL9, CXCR3, CCL3
16serine4410.6CCL3, CD69, CXCR3, IL9, MMP12
17calcium44 49 11 2413.6GZMA, SFTPD, CCL3, CCL23, CCL15, CCL25
18phosphatidylinositol4410.6SFTPD, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
19thymidine44 2411.5CCL3, SFTPD, CD69, CXCR3, IL9
20tyrosine4410.5GZMA, GREM1, CD69, CXCR3, CXCL5, CXCL9
21larc4410.4CXCR3, CCL3
22cysteine4410.4CD27, GREM1, GZMA, SFTPD, CCL3, CCL15
23isopentenyl diphosphate44 2811.4CCL3, CD69
24teck4410.3CCL3, CCL25
25mcp 14410.1CXCR3, CCL3

GO Terms for genes affiliated with Pulmonary Sarcoidosis

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16Gene Ontology
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Cellular components related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4CXCL9, CXCR3, CD27, CD69
2extracellular spaceGO:00561510.2IL9, CCL25, CCL15, CCL23, CCL3, SFTPD
3extracellular regionGO:00557610.0IFNA10, SFTPD, CCL3, CCL23, CCL25, IFNA17

Biological processes related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.6CXCL9, CCL25, CCL15, CCL23, CCL3, CXCR3
2T cell chemotaxisGO:01081810.6CXCR3, CCL3
3inflammatory responseGO:00695410.5CCL25, CCL23, CCL3, CXCR3, CXCR6, CXCL9
4immune responseGO:00695510.5CCL25, CCL15, CCL23, GZMA, CXCL5, CXCR6
5cell-cell signalingGO:00726710.5CCL15, CCL23, CCL3, GREM1, CXCL5, CXCL9
6cellular calcium ion homeostasisGO:00687410.5CCL15, CCL23, CCL3
7macrophage chemotaxisGO:04824610.4SFTPD, CCL3
8negative regulation of bone mineralizationGO:03050210.4GREM1, CCL3
9G-protein coupled receptor signaling pathwayGO:00718610.3CCL25, CCL23, CXCR6, CXCL9
10monocyte chemotaxisGO:00254810.1CCL3, CCL23

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.4CCL3, CCL15
2chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3, CCL23, CCL15, CCL25
3cytokine activityGO:00512510.4IFNA10, IFNA17, GREM1, CXCL9, IL9
4CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL23
5C-X-C chemokine receptor activityGO:01649410.2CXCR6, CXCR3

Products for genes affiliated with Pulmonary Sarcoidosis

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Sources for Pulmonary Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet