MCID: PLM012
MIFTS: 53

Pulmonary Sarcoidosis malady

Immune diseases, Respiratory diseases categories
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Summaries for Pulmonary Sarcoidosis

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33MalaCards
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MalaCards: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to sarcoidosis and pulmonary fibrosis. An important gene associated with Pulmonary Sarcoidosis is IFNA17 (interferon, alpha 17), and among its related pathways are Immune response IFN alpha beta signaling pathway and Interferon Pathway. The compounds ccl19 and groalpha have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Pulmonary Sarcoidosis

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8Disease Ontology, 31LifeMap Discoveryâ„¢, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Respiratory diseases


Aliases & Descriptions:

pulmonary sarcoidosis 8 31
sarcoidosis, pulmonary 62
sarcoidosis pulmonary 45
lung sarcoidosis 8


External Ids:

Disease Ontology8 DOID:13406
MeSH35 D017565
SNOMED-CT58 187230004, 24369008
NCIt40 C34997
ICD1025 D86.0, D86.2

Related Diseases for Pulmonary Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.7CD27, BTNL2, IL9, CXCL5, CXCR3, SFTPD
2pulmonary fibrosis30.6CXCR3, SFTPD
3idiopathic pulmonary fibrosis30.6IL9, CXCL5, CXCR3, SFTPD
4pneumonia30.5SFTPD, MMP12, CXCL5
5lung cancer30.3SFTPD, MMP12, CXCR3, IL9
6arthritis30.3CXCL5, CXCR3, MMP12
7interstitial lung disease30.1SFTPD
8multiple sclerosis30.1MMP12, CXCR3, IL9, CD27
9extrinsic allergic alveolitis30.0CXCR3, SFTPD
10atopy30.0CXCR3, IL9
11rheumatoid arthritis30.0CD27, CXCL5, CXCR3, MMP12, SFTPD
12influenza29.9CD27, CXCR3, SFTPD
13tuberculosis10.4
14pulmonary function10.3
15systemic lupus erythematosus10.3
16lupus erythematosus10.3
17blindness10.3
18ankylosing spondylitis10.2
19glomerulonephritis10.2
20spondylitis10.2
21cystic fibrosis10.1
22pulmonary tuberculosis10.1
23membranoproliferative glomerulonephritis10.1
24focal segmental glomerulosclerosis10.1
25amyloidosis10.1
26breast cancer10.1
27glomerulosclerosis10.1
28hypertension10.1
29mediastinitis10.1
30human immunodeficiency virus infectious disease10.1CD27
31reticulosarcoma10.0IL9, CXCR3
32anaplastic large cell lymphoma10.0CXCR3, IL9
33uveitis10.0IL9, CXCR3
34pulmonary emphysema10.0MMP12, SFTPD
35pulmonary disease, chronic obstructive10.0SFTPD, MMP12
36gastritis10.0SFTPD, CXCL5
37b-cell chronic lymphocytic leukemia10.0CD27, CXCR3
38allergic rhinitis10.0IL9, CXCR3
39encephalomyelitis10.0CXCR3, MMP12
40osteoarthritis10.0CXCL5, CXCR3, MMP12
41polycythemia vera10.0
42bronchiolitis10.0
43antiphospholipid syndrome10.0
44bronchiolitis obliterans10.0
45bronchiectasis10.0
46nocardiosis10.0
47autoimmune hemolytic anemia10.0
48ulcerative colitis10.0
49chronic myeloid leukemia10.0
50hypercalcemia10.0

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Symptoms for Pulmonary Sarcoidosis

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Drugs & Therapeutics for Pulmonary Sarcoidosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discoveryâ„¢, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

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Anatomical Context for Pulmonary Sarcoidosis

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Sarcoidosis:

33
Lung, T cells, Lymph node, Monocytes, Testes, Breast, Skin, Myeloid, Nk cells, Eye, Liver, Spleen, Bone, Endothelial

Animal Models for Pulmonary Sarcoidosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3MMP12, CXCR3, ACKR4, IL9, CD27, SFTPD
2MP:00053977.0CD27, IL9, ACKR4, CXCR3, MMP12, SFTPD

Publications for Pulmonary Sarcoidosis

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52PubMed
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Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Granuloma Formation in Pulmonary Sarcoidosis. (24339826)
2013
2
Typical and atypical pattern of pulmonary sarcoidosis at high-resolution CT: relation to clinical evolution and therapeutic procedures. (24297591)
2013
3
Hemophagocytic syndrome due to pulmonary sarcoidosis. (23147060)
2012
4
Differential expression of microRNA and predicted targets in pulmonary sarcoidosis. (22209793)
2012
5
Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis. (21463523)
2011
6
Small cell lung cancer complicated by pulmonary sarcoidosis. (20847506)
2010
7
Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis. (21092305)
2010
8
The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis. (20070603)
2010
9
Clinical challenges and images in GI. Early peripancreatic and pulmonary sarcoidosis. (19013164)
2008
10
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
11
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
12
Practical issues and challenges in the diagnosis and treatment of pulmonary sarcoidosis. (17209662)
2007
13
Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma). (17937104)
2006
14
Progressive pulmonary sarcoidosis--a fibroproliferative process potentially triggered by EGR-1 and IL-6. (16933469)
2006
15
Pulmonary sarcoidosis with usual interstitial pneumonia distributed predominantly in the lower lung fields. (16617185)
2006
16
Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis. (16954298)
2006
17
Tuberculin skin test among pulmonary sarcoidosis patients with and without tuberculosis: its utility for the screening of the two conditions in tuberculosis-endemic regions. (17937109)
2006
18
Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. (16507843)
2006
19
Granzymes A and B in pulmonary sarcoidosis (experimental study)]. (15947857)
2005
20
Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? (15763444)
2005
21
Corticosteroids for pulmonary sarcoidosis. (15846612)
2005
22
Trends and occupational associations in incidence of hospitalized pulmonary sarcoidosis and other lung diseases in Navy personnel: a 27-year historical prospective study, 1975-2001. (15539709)
2004
23
Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis. (14641797)
2003
24
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
25
Pulmonary sarcoidosis and the acute respiratory distress syndrome (ARDS). (12096212)
2002
26
CC chemokine receptor 5 (CCR5) mRNA expression in pulmonary sarcoidosis. (11803051)
2002
27
Ultrastructural study of expression of adhesion molecules between blood monocytes and alveolar macrophages from patients with pulmonary sarcoidosis. (11989775)
2001
28
Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis. (10957763)
2000
29
The prognosis of pulmonary sarcoidosis in Finland and Hokkaido, Japan. A comparative five-year study of biopsy-proven cases. (10957764)
2000
30
Hyperbaric chamber-related decompression illness in a patient with asymptomatic pulmonary sarcoidosis. (10373052)
1999
31
Microsatellite DNA instability and loss of heterozygosity in pulmonary sarcoidosis. (10556148)
1999
32
Lung transplantation for end-stage pulmonary sarcoidosis. (10207947)
1999
33
Medium term results of lung transplantation for end stage pulmonary sarcoidosis. (9741371)
1998
34
Malignant neoplasms in pulmonary sarcoidosis. (9797771)
1998
35
Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? (9305302)
1997
36
A simple radiographic scoring method for monitoring pulmonary sarcoidosis: relations between radiographic scores, dyspnoea grade and respiratory function in the British Thoracic Society Study of Long-Term Corticosteroid Treatment. (9186989)
1997
37
Hydroxychloroquine therapy of diffuse pulmonary sarcoidosis in two Australian male children. (9424408)
1997
38
Glucocorticosteroids and pulmonary sarcoidosis. (8779121)
1996
39
Limited heterogeneity of biased T-cell receptor V beta gene usage in lung but not blood T cells in active pulmonary sarcoidosis. (8881751)
1996
40
Why perform high resolution computed tomography in pulmonary sarcoidosis? (8140309)
1993
41
Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis. (8396372)
1993
42
Standardized quantitative 67Ga scintigraphy in relation to carbon monoxide diffusion capacity in pulmonary sarcoidosis. (8134713)
1993
43
Clonal expansion of lung V delta 1+ T cells in pulmonary sarcoidosis. (8423227)
1993
44
Preferential usage of the T-cell antigen receptor beta-chain constant region C beta 1 element by lung T-lymphocytes of patients with pulmonary sarcoidosis. (1848052)
1991
45
Glucose, K+, and albumin concentrations in the alveolar milieu of normal humans and pulmonary sarcoidosis patients. (2024821)
1991
46
Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis. (1680610)
1991
47
Changes in interleukin-2 receptor levels in active and inactive pulmonary sarcoidosis]. (1870863)
1991
48
Lavage versus serum measurements of lysozyme, angiotensin converting enzyme and other inflammatory markers in pulmonary sarcoidosis. (1965306)
1990
49
Fibroblast growth-stimulating activity in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. (2101407)
1990
50
Diagnosis and management of pulmonary sarcoidosis. (2691190)
1989

Variations for Pulmonary Sarcoidosis

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Expression for genes affiliated with Pulmonary Sarcoidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

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Sources:
50PathCards, 60Thomson Reuters, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems
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Pathways related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9IFNA17, IFNA10
29.9IFNA10, IFNA17
3
Show member pathways
9.9IFNA17, IFNA10
49.9IFNA17, IFNA10
59.9IFNA17, IFNA10
6
Show member pathways
9.5IFNA10, IFNA17, IL9
79.5IFNA10, IFNA17, IL9
8
Show member pathways
Type III interferon signaling38
9.5IL9, IFNA17, IFNA10
9
Show member pathways
9.2ACKR4, CXCL5, CXCR3
10
Show member pathways
8.9CXCL5, CXCR3, MMP12
11
Show member pathways
8.1CD27, IL9, IFNA17, IFNA10, CXCL5, CXCR3

Compounds for genes affiliated with Pulmonary Sarcoidosis

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29IUPHAR, 45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank
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Compounds related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ccl19299.8ACKR4, CXCR3
2groalpha459.8CXCL5, CXCR3
3tarc459.7IL9, CXCL5, CXCR3
4ccl345 2910.6CXCL5, CXCR3
5allergens459.5IL9, CXCR3, SFTPD
6endotoxin459.5CXCL5, CXCR3, SFTPD
7rantes459.5IL9, CXCL5, CXCR3
8ccl445 2910.4CXCR3, CXCL5
9histamine45 29 2411.3SFTPD, CXCR3, IL9
10etanercept45 51 1111.2CXCR3, MMP12
11thymidine45 2410.2IL9, CXCR3, SFTPD
12oligonucleotide458.7SFTPD, MMP12, CXCL5, IL9
13dexamethasone45 51 29 1111.6SFTPD, MMP12, CXCR3, CXCL5
14nitric oxide45 24 1110.3SFTPD, MMP12, CXCR3, CXCL5, IL9
15serine458.0SFTPD, MMP12, CXCR3, IL9, CD27
16calcium45 51 24 1110.6SFTPD, MMP12, CXCR3, CXCL5, ACKR4, CD27

GO Terms for genes affiliated with Pulmonary Sarcoidosis

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16Gene Ontology
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Cellular components related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7IL9, IFNA17, IFNA10, CXCL5, SFTPD
2extracellular regionGO:0055767.3CD27, SFTPD, MMP12, CXCL5, IFNA10, IFNA17

Biological processes related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1natural killer cell activation involved in immune responseGO:00232310.1IFNA17, IFNA10
2regulation of MHC class I biosynthetic processGO:04534310.1IFNA17, IFNA10
3positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.1IFNA10, IFNA17
4T cell activation involved in immune responseGO:00228610.1IFNA17, IFNA10
5regulation of type I interferon-mediated signaling pathwayGO:06033810.1IFNA17, IFNA10
6B cell proliferationGO:04210010.0IFNA17, IFNA10
7response to exogenous dsRNAGO:04333010.0IFNA10, IFNA17
8adaptive immune responseGO:00225010.0IFNA17, IFNA10
9humoral immune responseGO:0069599.9IFNA10, IFNA17
10B cell differentiationGO:0301839.8IFNA17, IFNA10
11type I interferon signaling pathwayGO:0603379.6IFNA17, IFNA10
12chemotaxisGO:0069359.5ACKR4, CXCL5, CXCR3
13positive regulation of cell proliferationGO:0082849.3IL9, CXCL5, CXCR3
14immune responseGO:0069559.3IL9, ACKR4, CXCL5

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon receptor bindingGO:0051329.8IFNA17, IFNA10
2chemokine bindingGO:0199569.5ACKR4, CXCR3
3chemokine receptor activityGO:0049509.5ACKR4, CXCR3
4cytokine activityGO:0051259.2IL9, IFNA17, IFNA10

Products for genes affiliated with Pulmonary Sarcoidosis

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  • Antibodies
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  • Antibodies

Sources for Pulmonary Sarcoidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet