MCID: PLM012
MIFTS: 45

Pulmonary Sarcoidosis malady

Immune diseases, Respiratory diseases categories

Aliases & Classifications for Pulmonary Sarcoidosis

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Pulmonary Sarcoidosis, Aliases & Descriptions:

Name: Pulmonary Sarcoidosis 30 9
Sarcoidosis, Pulmonary 60
 
Sarcoidosis Pulmonary 43
Lung Sarcoidosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Respiratory diseases


External Ids:

Disease Ontology9 DOID:13406
NCIt38 C34997
SNOMED-CT55 24369008, 187230004
MeSH33 D017565
ICD1025 D86.0, D86.2

Summaries for Pulmonary Sarcoidosis

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MalaCards based summary: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to pulmonary fibrosis and pneumonia. An important gene associated with Pulmonary Sarcoidosis is IFNA17 (interferon, alpha 17), and among its related pathways are Immune response IFN alpha beta signaling pathway and Interferon Pathway. The compounds ccl19 and groalpha have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Related Diseases for Pulmonary Sarcoidosis

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Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary fibrosis30.7CXCR3, SFTPD
2pneumonia30.6SFTPD, MMP12, CXCL5
3interstitial lung disease30.5SFTPD
4arthritis30.3CXCL5, CXCR3, MMP12
5lung cancer30.3CXCL5, MMP12, SFTPD
6extrinsic allergic alveolitis30.3CXCR3, SFTPD
7atopy30.2CXCR3, IL9
8influenza29.7CD27, CXCR3, SFTPD
9rheumatoid arthritis29.4CD27, CXCL5, CXCR3, MMP12, SFTPD
10sarcoidosis 128.9CD27, BTNL2, IL9, CXCL5, CXCR3, SFTPD
11tuberculosis10.5
12blindness10.4
13pulmonary function10.4
14systemic lupus erythematosus10.3
15lupus erythematosus10.3
16breast cancer10.2
17amyloidosis10.2
18spondylitis10.2
19human immunodeficiency virus infectious disease10.2CD27
20reticulosarcoma10.2IL9, CXCR3
21anaplastic large cell lymphoma10.2CXCR3, IL9
22cystic fibrosis10.2
23pulmonary hypertension10.2
24focal segmental glomerulosclerosis10.2
25glomerulonephritis10.2
26pulmonary tuberculosis10.2
27glomerulosclerosis10.2
28mediastinitis10.2
29psoriasis10.2
30pulmonary emphysema10.1MMP12, SFTPD
31uveitis10.1IL9, CXCR3
32pulmonary disease, chronic obstructive10.1SFTPD, MMP12
33gastritis10.1SFTPD, CXCL5
34squamous cell carcinoma, head and neck10.1CD27, CXCR3
35pulmonary alveolar microlithiasis10.0
36polycythemia vera10.0
37pancreatic cancer10.0
38moyamoya disease10.0
39lipoma10.0
40psoriatic arthritis10.0
41bronchiolitis obliterans10.0
42cutaneous leishmaniasis10.0
43hemolytic anemia10.0
44leukemia10.0
45primary biliary cirrhosis10.0
46ulcerative colitis10.0
47bronchiolitis10.0
48antiphospholipid syndrome10.0
49membranoproliferative glomerulonephritis10.0
50bronchiectasis10.0

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Symptoms for Pulmonary Sarcoidosis

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Drugs & Therapeutics for Pulmonary Sarcoidosis

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

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Anatomical Context for Pulmonary Sarcoidosis

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MalaCards organs/tissues related to Pulmonary Sarcoidosis:

31
Lung, T cells, Lymph node, Testes, Monocytes, Breast, Neutrophil, Skin, Myeloid, Eye, Bone, Spleen, Liver, Nk cells, Endothelial

Animal Models for Pulmonary Sarcoidosis or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3MMP12, CXCR3, ACKR4, IL9, CD27, SFTPD
2MP:00053977.0CD27, IL9, ACKR4, CXCR3, MMP12, SFTPD

Publications for Pulmonary Sarcoidosis

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Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Granuloma Formation in Pulmonary Sarcoidosis. (24339826)
2013
2
Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis. (23668840)
2013
3
Typical and atypical pattern of pulmonary sarcoidosis at high-resolution CT: relation to clinical evolution and therapeutic procedures. (24297591)
2013
4
Hemophagocytic syndrome due to pulmonary sarcoidosis. (23147060)
2012
5
Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis. (21463523)
2011
6
Small cell lung cancer complicated by pulmonary sarcoidosis. (20847506)
2010
7
Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis. (21092305)
2010
8
The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis. (20070603)
2010
9
Clinical challenges and images in GI. Early peripancreatic and pulmonary sarcoidosis. (19013164)
2008
10
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
11
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
12
Practical issues and challenges in the diagnosis and treatment of pulmonary sarcoidosis. (17209662)
2007
13
Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma). (17937104)
2006
14
Progressive pulmonary sarcoidosis--a fibroproliferative process potentially triggered by EGR-1 and IL-6. (16933469)
2006
15
Pulmonary sarcoidosis with usual interstitial pneumonia distributed predominantly in the lower lung fields. (16617185)
2006
16
Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis. (16954298)
2006
17
Tuberculin skin test among pulmonary sarcoidosis patients with and without tuberculosis: its utility for the screening of the two conditions in tuberculosis-endemic regions. (17937109)
2006
18
Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. (16507843)
2006
19
Granzymes A and B in pulmonary sarcoidosis (experimental study)]. (15947857)
2005
20
Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? (15763444)
2005
21
Corticosteroids for pulmonary sarcoidosis. (15846612)
2005
22
Trends and occupational associations in incidence of hospitalized pulmonary sarcoidosis and other lung diseases in Navy personnel: a 27-year historical prospective study, 1975-2001. (15539709)
2004
23
Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis. (14641797)
2003
24
Fluorodeoxyglucose PET scan in pulmonary sarcoidosis during treatment with inhaled and oral corticosteroids. (14512678)
2003
25
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
26
Pulmonary sarcoidosis and the acute respiratory distress syndrome (ARDS). (12096212)
2002
27
CC chemokine receptor 5 (CCR5) mRNA expression in pulmonary sarcoidosis. (11803051)
2002
28
Ultrastructural study of expression of adhesion molecules between blood monocytes and alveolar macrophages from patients with pulmonary sarcoidosis. (11989775)
2001
29
Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis. (10957763)
2000
30
The prognosis of pulmonary sarcoidosis in Finland and Hokkaido, Japan. A comparative five-year study of biopsy-proven cases. (10957764)
2000
31
Hyperbaric chamber-related decompression illness in a patient with asymptomatic pulmonary sarcoidosis. (10373052)
1999
32
Microsatellite DNA instability and loss of heterozygosity in pulmonary sarcoidosis. (10556148)
1999
33
Lung transplantation for end-stage pulmonary sarcoidosis. (10207947)
1999
34
Medium term results of lung transplantation for end stage pulmonary sarcoidosis. (9741371)
1998
35
Malignant neoplasms in pulmonary sarcoidosis. (9797771)
1998
36
Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? (9305302)
1997
37
A simple radiographic scoring method for monitoring pulmonary sarcoidosis: relations between radiographic scores, dyspnoea grade and respiratory function in the British Thoracic Society Study of Long-Term Corticosteroid Treatment. (9186989)
1997
38
Hydroxychloroquine therapy of diffuse pulmonary sarcoidosis in two Australian male children. (9424408)
1997
39
Glucocorticosteroids and pulmonary sarcoidosis. (8779121)
1996
40
Limited heterogeneity of biased T-cell receptor V beta gene usage in lung but not blood T cells in active pulmonary sarcoidosis. (8881751)
1996
41
Why perform high resolution computed tomography in pulmonary sarcoidosis? (8140309)
1993
42
Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis. (8396372)
1993
43
Standardized quantitative 67Ga scintigraphy in relation to carbon monoxide diffusion capacity in pulmonary sarcoidosis. (8134713)
1993
44
Preferential usage of the T-cell antigen receptor beta-chain constant region C beta 1 element by lung T-lymphocytes of patients with pulmonary sarcoidosis. (1848052)
1991
45
Glucose, K+, and albumin concentrations in the alveolar milieu of normal humans and pulmonary sarcoidosis patients. (2024821)
1991
46
Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis. (1680610)
1991
47
Changes in interleukin-2 receptor levels in active and inactive pulmonary sarcoidosis]. (1870863)
1991
48
Lavage versus serum measurements of lysozyme, angiotensin converting enzyme and other inflammatory markers in pulmonary sarcoidosis. (1965306)
1990
49
Fibroblast growth-stimulating activity in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. (2101407)
1990
50
Diagnosis and management of pulmonary sarcoidosis. (2691190)
1989

Variations for Pulmonary Sarcoidosis

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Expression for genes affiliated with Pulmonary Sarcoidosis

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Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

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Pathways related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9IFNA17, IFNA10
29.9IFNA10, IFNA17
3
Show member pathways
9.9IFNA17, IFNA10
49.9IFNA17, IFNA10
59.9IFNA17, IFNA10
6
Show member pathways
9.5IFNA10, IFNA17, IL9
79.5IFNA10, IFNA17, IL9
8
Show member pathways
Type III interferon signaling36
9.5IL9, IFNA17, IFNA10
9
Show member pathways
9.2ACKR4, CXCL5, CXCR3
10
Show member pathways
8.9CXCL5, CXCR3, MMP12
11
Show member pathways
8.1CD27, IL9, IFNA17, IFNA10, CXCL5, CXCR3

Compounds for genes affiliated with Pulmonary Sarcoidosis

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Sources:
28IUPHAR, 43Novoseek, 24HMDB, 49PharmGKB, 12DrugBank
See all sources

Compounds related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ccl19289.8ACKR4, CXCR3
2groalpha439.8CXCL5, CXCR3
3tarc439.7IL9, CXCL5, CXCR3
4ccl343 2810.6CXCL5, CXCR3
5allergens439.5IL9, CXCR3, SFTPD
6endotoxin439.5CXCL5, CXCR3, SFTPD
7rantes439.5IL9, CXCL5, CXCR3
8ccl443 2810.4CXCR3, CXCL5
9histamine43 28 2411.3SFTPD, CXCR3, IL9
10etanercept43 49 1211.2CXCR3, MMP12
11thymidine43 2410.2IL9, CXCR3, SFTPD
12oligonucleotide438.7SFTPD, MMP12, CXCL5, IL9
13dexamethasone43 49 28 1211.6SFTPD, MMP12, CXCR3, CXCL5
14nitric oxide43 24 1210.3SFTPD, MMP12, CXCR3, CXCL5, IL9
15serine438.0SFTPD, MMP12, CXCR3, IL9, CD27
16calcium43 49 24 1210.6SFTPD, MMP12, CXCR3, CXCL5, ACKR4, CD27

GO Terms for genes affiliated with Pulmonary Sarcoidosis

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Cellular components related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7IL9, IFNA17, IFNA10, CXCL5, SFTPD
2extracellular regionGO:00055767.3CD27, SFTPD, MMP12, CXCL5, IFNA10, IFNA17

Biological processes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1natural killer cell activation involved in immune responseGO:000232310.1IFNA17, IFNA10
2regulation of MHC class I biosynthetic processGO:004534310.1IFNA17, IFNA10
3positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:003314110.1IFNA10, IFNA17
4T cell activation involved in immune responseGO:000228610.1IFNA17, IFNA10
5regulation of type I interferon-mediated signaling pathwayGO:006033810.1IFNA17, IFNA10
6B cell proliferationGO:004210010.0IFNA17, IFNA10
7response to exogenous dsRNAGO:004333010.0IFNA10, IFNA17
8adaptive immune responseGO:000225010.0IFNA17, IFNA10
9humoral immune responseGO:00069599.9IFNA10, IFNA17
10B cell differentiationGO:00301839.8IFNA17, IFNA10
11type I interferon signaling pathwayGO:00603379.6IFNA17, IFNA10
12chemotaxisGO:00069359.5ACKR4, CXCL5, CXCR3
13positive regulation of cell proliferationGO:00082849.3IL9, CXCL5, CXCR3
14immune responseGO:00069559.3IL9, ACKR4, CXCL5

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I interferon receptor bindingGO:00051329.8IFNA17, IFNA10
2chemokine bindingGO:00199569.5ACKR4, CXCR3
3chemokine receptor activityGO:00049509.5ACKR4, CXCR3
4cytokine activityGO:00051259.2IL9, IFNA17, IFNA10

Products for genes affiliated with Pulmonary Sarcoidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pulmonary Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet