MCID: PLM012
MIFTS: 58

Pulmonary Sarcoidosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sarcoidosis

MalaCards integrated aliases for Pulmonary Sarcoidosis:

Name: Pulmonary Sarcoidosis 37 12 14
Sarcoidosis, Pulmonary 72 41 69
Sarcoidosis Pulmonary 51
Lung Sarcoidosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13406
ICD10 32 D86.0 D86.2
MeSH 41 D017565
NCIt 46 C34997
SNOMED-CT 64 187230004 24369008
UMLS 69 C0036205

Summaries for Pulmonary Sarcoidosis

MalaCards based summary : Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to chronic beryllium disease and bronchiolitis obliterans. An important gene associated with Pulmonary Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azathioprine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as... more...

Related Diseases for Pulmonary Sarcoidosis

Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 chronic beryllium disease 30.1 IFNG TNF
2 bronchiolitis obliterans 29.9 CXCR3 IFNG TNF
3 mycobacterium tuberculosis 1 29.8 CXCR3 IFNG IL18 TNF
4 bronchiolitis 29.8 CCL5 IFNG TNF
5 pneumonia 29.8 CCL2 CCL5 SFTPD TNF
6 lymphopenia 29.3 IFNG IL2 IL2RA
7 respiratory failure 29.2 ACE SFTPD TNF
8 ulcerative colitis 29.1 IFNG IL2 TNF
9 interstitial lung disease 29.0 CCL2 CCL5 IFNG SFTPD TNF
10 lung disease 28.9 CCL2 CCL5 CSF2 SFTPD TNF
11 pleurisy 28.9 CCL2 ICAM1 IFNG IL2 TNF
12 pulmonary tuberculosis 28.9 IFNG IL18 IL2 TNF
13 arthritis 28.8 CCL2 CSF2 IFNG IL18 TNF
14 extrinsic allergic alveolitis 28.8 CCL2 CCL5 CXCR3 IL2RA SFTPD
15 renal cell carcinoma, nonpapillary 28.3 CSF2 CXCR3 ICAM1 IFNG IL2 IL2RA
16 pulmonary fibrosis, idiopathic 28.0 CCL2 CCL5 CXCL5 CXCR3 IFNG IL18
17 multiple sclerosis 27.8 CCL2 CCL5 CCR5 CXCR3 ICAM1 IFNG
18 psoriasis 27.1 CCL2 CCL5 CXCR3 ICAM1 IFNG IL18
19 systemic lupus erythematosus 27.0 CCL2 CCL5 CCR5 CXCR3 ICAM1 IFNG
20 asthma 26.9 CCL2 CCL5 CSF2 CXCL5 ICAM1 IFNG
21 rheumatoid arthritis 26.9 CCL2 CCL5 CSF2 CXCL5 ICAM1 IFNG
22 sarcoidosis 1 26.0 ACE CCL2 CCL5 CXCL5 CXCR3 ICAM1
23 staphylococcal toxic shock syndrome 10.5 IFNG TNF
24 scorpion envenomation 10.5 CCL5 TNF
25 hyperlucent lung 10.5 IFNG IL2RA
26 herpes simplex virus keratitis 10.4 CCL2 ICAM1
27 african tick-bite fever 10.4 CCL5 IFNG
28 whiplash 10.4 CCL5 CCR5
29 anthracosis 10.4 CCL2 TNF
30 ileocolitis 10.4 IL2RA TNF
31 poliomyelitis 10.4 ICAM1 IFNG TNF
32 plasmodium vivax malaria 10.4 ICAM1 IFNG TNF
33 toxoplasmosis 10.4 CCR5 IFNG TNF
34 proliferative glomerulonephritis 10.4 CCL2 CXCR3 IFNG
35 spotted fever 10.4 CCL5 IFNG TNF
36 subacute cutaneous lupus erythematosus 10.3 ACE TNF
37 autoimmune enteropathy 10.3 ICAM1 IL2RA
38 helicobacter pylori infection 10.3 CCL5 IFNG TNF
39 mucocutaneous leishmaniasis 10.3 CCR5 TNF
40 skin sarcoidosis 10.3 ACE TNF
41 meningitis 10.3 CCL2 IFNG TNF
42 oral tuberculosis 10.3 IL2 TNF
43 periodontitis 10.3 CCL2 IFNG TNF
44 chronic eosinophilic pneumonia 10.3 CCL5 CXCR3 ICAM1
45 scleritis 10.3 CCL2 TNF
46 vernal keratoconjunctivitis 10.3 CCL5 CXCR3 ICAM1
47 wegener granulomatosis 10.3 CCR5 IFNG TNF
48 alcoholic hepatitis 10.3 CCL2 ICAM1 TNF
49 viral meningitis 10.3 CCL2 CCL5 IFNG
50 crescentic glomerulonephritis 10.3 CCL2 CCR5 ICAM1

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to Pulmonary Sarcoidosis

Symptoms & Phenotypes for Pulmonary Sarcoidosis

GenomeRNAi Phenotypes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE ICAM1 IL18 IL2 IL2RA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 TNF ACE ICAM1 IL18 IL2 IL2RA

MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 IL2 IL2RA SFTPD TNF CXCR3 ACE
2 immune system MP:0005387 10.13 IL2RA SFTPD TNF CXCR3 IL2 ACE
3 cardiovascular system MP:0005385 10.11 TNF IL2 CXCR3 ACE ICAM1 CCR5
4 homeostasis/metabolism MP:0005376 10.11 TNF IL2 IL2RA SFTPD CXCR3 ACE
5 mortality/aging MP:0010768 10 TNF IL2 IL2RA SFTPD CSF2 IL18
6 digestive/alimentary MP:0005381 9.98 TNF IL2 IL2RA IL18 ICAM1 CCR5
7 neoplasm MP:0002006 9.76 IL2 TNF CXCR3 ACE ICAM1 CCR5
8 respiratory system MP:0005388 9.5 TNF IL2 IL2RA SFTPD CXCR3 IFNG
9 vision/eye MP:0005391 9.17 TNF IL2 IL2RA IL18 ICAM1 CCR5

Drugs & Therapeutics for Pulmonary Sarcoidosis

Drugs for Pulmonary Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 1 53-03-2 5865
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
6
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
7
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 89594 942
8
Acetylcholine Approved Phase 4 51-84-3 187
9 Adrenocorticotropic Hormone Phase 4
10 beta-endorphin Phase 4
11 Hormone Antagonists Phase 4,Phase 3,Phase 1
12 Hormones Phase 4,Phase 3,Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1
14 Melanocyte-Stimulating Hormones Phase 4
15 Antiemetics Phase 4,Phase 3,Phase 1
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 1
18 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
20 glucocorticoids Phase 4,Phase 3,Phase 1
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Protective Agents Phase 4,Phase 2,Phase 1
23 Antirheumatic Agents Phase 4,Phase 3,Phase 2
24 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
25 Immunosuppressive Agents Phase 4,Phase 2
26 Methylprednisolone acetate Phase 4,Phase 1
27 Methylprednisolone Hemisuccinate Phase 4,Phase 1
28 Neuroprotective Agents Phase 4,Phase 1
29 Prednisolone acetate Phase 4,Phase 1
30 Prednisolone hemisuccinate Phase 4,Phase 1
31 Prednisolone phosphate Phase 4,Phase 1
32 Analgesics Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4
35 Central Nervous System Stimulants Phase 4,Phase 1,Phase 2
36 Cholinergic Agents Phase 4,Phase 1,Phase 2
37 Nicotinic Agonists Phase 4,Phase 1,Phase 2
38
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
39
Hydroxychloroquine Approved Phase 3 118-42-3 3652
40
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
41
Mycophenolic acid Approved Phase 3 24280-93-1 446541
42 BB 1101 Phase 3
43 Dexamethasone acetate Phase 3 1177-87-3
44 HIV Protease Inhibitors Phase 3
45
protease inhibitors Phase 3
46 Anti-Infective Agents Phase 3,Phase 2,Phase 1
47 Antimalarials Phase 3
48 Antiparasitic Agents Phase 3
49 Antiprotozoal Agents Phase 3
50 Antibodies Phase 3,Phase 2

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Unknown status NCT02188017 Phase 4 Acthar gel
2 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Unknown status NCT01830959 Phase 4 Roflumilast;Placebo
3 Pilot Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in Subjects With Pulmonary Sarcoidosis Recruiting NCT03320070 Phase 4 repository corticotropin injection;Placebo
4 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
5 Pirfenidone for Progressive Fibrotic Sarcoidosis Recruiting NCT03260556 Phase 4 Pirfenidone;Placebos
6 Study of Nicotine Patches in Patients With Sarcoidosis Suspended NCT00701207 Phase 4 nicotine patch
7 Low-dose Dexamethasone in Newly Diagnosed Pulmonary Sarcoidosis Unknown status NCT01920919 Phase 3 Dexamethasone;Placebo
8 Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS). Completed NCT02200146 Phase 3 Prednisone;Hydroxychloroquine + Prednisone
9 Antibody Response to Influenza Vaccine in Patients With Sarcoidosis Completed NCT00828828 Phase 3
10 Trial for the Diagnosis of Sarcoidosis Completed NCT00872612 Phase 3
11 Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Recruiting NCT02824419 Phase 2, Phase 3 Methionine;DOTANOC
12 Mycophenolate for Pulmonary Sarcoidosis Terminated NCT00262132 Phase 3 Mycophenolate
13 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed NCT00001877 Phase 2 Pentoxifylline
14 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2 Atorvastatin
15 Rituximab for Pulmonary Sarcoidosis Completed NCT00855205 Phase 2 Rituximab
16 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
17 Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis Recruiting NCT02888080 Phase 2 ACZ885;Placebo
18 Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis Recruiting NCT02024555 Phase 2 Levofloxacin;Ethambutol;Azithromycin;Rifampin;Placebo
19 Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study Recruiting NCT02265874 Phase 1, Phase 2 Habitrol;Placebo to Habitrol
20 A Phase 2, Safety, Tolerability, and Efficacy Study of PD 0360324 in Chronic Pulmonary Sarcoidosis Terminated NCT01732211 Phase 2
21 Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis Terminated NCT00926627 Phase 2 bosentan;placebo
22 Safety Study of Abatacept to Treat Refractory Sarcoidosis Terminated NCT00739960 Phase 2 Abatacept
23 Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis Completed NCT01169038 Phase 1 levaquin; ethambutol; rifampin and azithromycin.
24 A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis Not yet recruiting NCT03324503 Phase 1 Glucocorticoid (prednisone or prednisolone)
25 Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis Terminated NCT01440192 Phase 1
26 Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study Unknown status NCT01384123
27 The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis Completed NCT01587001 Placebo
28 Sarcoidosis-associated Pulmonary Hypertension Completed NCT01139710
29 The Occurence of Inflammation and Oxidative Stress in Lung Diseases Completed NCT00512967
30 Pathogen Specific Immunity in Patients With Sarcoidosis Completed NCT00217789
31 A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma Completed NCT01097954
32 Eye and Immunogenetic Features of Sarcoidosis Completed NCT00379275
33 The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis Recruiting NCT03336736
34 Pulmonary Rehabilitation in Patients With Sarcoidosis Recruiting NCT02044939
35 SARCOLOWDOSE : Ultra-low Dose CT Scan and MRI in Thoracic Sarcoidosis Recruiting NCT03140644 Not Applicable
36 Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis Recruiting NCT03145922
37 Validation of the Analysis Methodology Behind the Use of Quantitative 18F-FDG PET/CT to Assess Lung Inflammation Not yet recruiting NCT03312712
38 Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease Not yet recruiting NCT03455686 Not Applicable
39 Stromal Gene Expression During Pulmonary Sarcoidosis Terminated NCT00837668

Search NIH Clinical Center for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived cells PMIDs: 22469567

Cochrane evidence based reviews: sarcoidosis, pulmonary

Genetic Tests for Pulmonary Sarcoidosis

Anatomical Context for Pulmonary Sarcoidosis

MalaCards organs/tissues related to Pulmonary Sarcoidosis:

38
Lung, T Cells, Lymph Node, Eye, Skin, Liver, Heart

Publications for Pulmonary Sarcoidosis

Articles related to Pulmonary Sarcoidosis:

(show top 50) (show all 629)
# Title Authors Year
1
Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity. ( 29107084 )
2018
2
Daily home spirometry to detect early steroid treatment effects in newly treated pulmonary sarcoidosis. ( 29348185 )
2018
3
Right ventricular involvement and the extent of left ventricular enhancement with magnetic resonance predict adverse outcome in pulmonary sarcoidosis. ( 28967698 )
2018
4
Atypical HRCT manifestations of pulmonary sarcoidosis. ( 29124658 )
2018
5
Th17-lineage cells in pulmonary sarcoidosis and LAPfgren's syndrome: Friend or foe? ( 29310925 )
2018
6
Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ( 27826889 )
2017
7
Pulmonary Sarcoidosis That Developed During the Treatment of a Patient With Crohn Disease by Using Infliximab. ( 28503520 )
2017
8
[Analysis of an association of TNF -308G>A polymorphism with a risk for pulmonary sarcoidosis in the Russian population of the Republic of Karelia]. ( 28378732 )
2017
9
Immunology repertoire study of pulmonary sarcoidosis T cells in CD4+, CD8+ PBMC and tissue. ( 29163767 )
2017
10
Strategies for identifying pulmonary sarcoidosis patients at risk for severe or chronic disease. ( 28076979 )
2017
11
Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis. ( 29104468 )
2017
12
Living Kidney Donation From a Donor With Pulmonary Sarcoidosis: AA Case Report and Review of the Literature. ( 28583552 )
2017
13
Pulmonary Sarcoidosis in a patient with Multiple Sclerosis on daclizumab monotherapy. ( 29276998 )
2017
14
Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review. ( 28671172 )
2017
15
Resolution rate of pulmonary sarcoidosis and its related factors in a Japanese population. ( 28712145 )
2017
16
Pulmonary Sarcoidosis Presenting with Thin-walled Small Cysts. ( 28420852 )
2017
17
Pulmonary Sarcoidosis. ( 28750459 )
2017
18
Title: Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis. ( 29237089 )
2017
19
Local and Systemic CD4<sup>+</sup>T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. ( 29234685 )
2017
20
Predictors of Mortality in Pulmonary Sarcoidosis. ( 28728933 )
2017
21
Clinical Features of Pulmonary Sarcoidosis Complicated by Lung Cancer. ( 28768963 )
2017
22
Pulmonary sarcoidosis mimicking tuberculosis: Importance of the galaxy sign on thoracic computed tomography. ( 28863878 )
2017
23
Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis. ( 27682024 )
2017
24
No evidence found for an association between prednisone dose and FVC change in newly-treated pulmonary sarcoidosis. ( 29137908 )
2017
25
Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma. ( 28737580 )
2017
26
Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ( 28229082 )
2017
27
Repository corticotropin for Chronic Pulmonary Sarcoidosis. ( 28353116 )
2017
28
Ulcerating Nodules within Tattoos Revealing Pulmonary Sarcoidosis. ( 28881429 )
2017
29
Pulmonary sarcoidosis: an update. ( 27766929 )
2017
30
The Pathogenesis of Pulmonary Sarcoidosis and Implications for Treatment. ( 29224832 )
2017
31
Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept. ( 28124746 )
2017
32
Pulmonary sarcoidosis induced by the anti-PD-1 monoclonal antibody pembrolizumab or post-immunotherapy granulomatous reaction: which is more appropriate terminology? ( 27143637 )
2016
33
T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis. ( 26585430 )
2016
34
Dementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis. ( 28127435 )
2016
35
Predictors of objective cough frequency in pulmonary sarcoidosis. ( 26846840 )
2016
36
Clinical and radiological features of extra-pulmonary sarcoidosis: a pictorial essay. ( 27222055 )
2016
37
Pulmonary metastases from low grade sarcoma in a patient with pulmonary sarcoidosis. Sarcoidosis or sarcoid-like reaction? ( 27537721 )
2016
38
The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without LAPfgren's Syndrome. ( 28050119 )
2016
39
Nephrology: Instructive case haemorrhagic cystitis due to BK virus in an adult with cardiac & pulmonary sarcoidosis. ( 27546780 )
2016
40
The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis. ( 26831541 )
2016
41
Pulmonary Sarcoidosis: Diagnosis and Treatment. ( 27378039 )
2016
42
Functional TLR9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. ( 27390897 )
2016
43
Altered miRNA expression in pulmonary sarcoidosis. ( 26768132 )
2016
44
Clinical significance of the "galaxy sign" in patients with pulmonary sarcoidosis in a Japanese single-center cohort. ( 27758990 )
2016
45
CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis. ( 27701118 )
2016
46
Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ( 27645544 )
2016
47
Treatment indications for pulmonary sarcoidosis. ( 27055843 )
2016
48
Exhaled nitric oxide is not increased in pulmonary sarcoidosis. ( 27055834 )
2016
49
Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. ( 27055833 )
2016
50
Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules. ( 27566455 )
2016

Variations for Pulmonary Sarcoidosis

Expression for Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for Pulmonary Sarcoidosis

Pathways related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
2
Show member pathways
13.81 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
3
Show member pathways
13.6 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
4
Show member pathways
13.54 CCL2 CCL5 ICAM1 IFNG IL18 IL2
5
Show member pathways
13.36 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
6
Show member pathways
13.29 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
7
Show member pathways
13.17 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
8
Show member pathways
12.87 CCL2 CCL5 CCR5 CXCL5 CXCR3
9
Show member pathways
12.86 ICAM1 IFNG IL2 IL2RA TNF
10
Show member pathways
12.75 CCL2 CCL5 ICAM1 IFNG IL18 IL2
11
Show member pathways
12.66 IFNG IL18 IL2 IL2RA TNF
12
Show member pathways
12.63 IFNG IL18 IL2 IL2RA TNF
13
Show member pathways
12.62 CCL2 IFNG IL18 IL2 TNF
14 12.62 CCL2 CCL5 IFNG IL2 IL2RA TNF
15
Show member pathways
12.59 ACE CCL2 CCL5 IFNG IL2 TNF
16
Show member pathways
12.56 CSF2 ICAM1 IFNG IL2 TNF
17
Show member pathways
12.55 CCR5 CSF2 ICAM1 TNF
18
Show member pathways
12.48 CCR5 CSF2 IFNG IL2 TNF
19 12.47 CSF2 ICAM1 IL2 IL2RA TNF
20
Show member pathways
12.39 CSF2 IFNG IL2 IL2RA
21
Show member pathways
12.39 CCL2 CSF2 CXCL5 IFNG TNF
22
Show member pathways
12.37 CCL2 CCL5 ICAM1 IFNG IL2 TNF
23
Show member pathways
12.25 CCL2 CCL5 CCR5 CXCL5 CXCR3 ICAM1
24
Show member pathways
12.2 IFNG IL18 IL2 TNF
25 12.14 CCL2 ICAM1 IFNG TNF
26 12.09 CCL2 ICAM1 IFNG IL2 TNF
27
Show member pathways
12.07 CCL2 CCL5 CCR5 CXCL5 CXCR3
28 12.06 CSF2 IFNG IL2 IL2RA TNF
29
Show member pathways
12.04 IFNG IL2 IL2RA
30 12.04 CCL2 ICAM1 IL18 TNF
31
Show member pathways
12.04 CCR5 IFNG IL18 IL2 IL2RA
32
Show member pathways
11.99 IFNG IL18 IL2 TNF
33 11.91 CCR5 IFNG IL2 IL2RA
34 11.9 CCL2 ICAM1 TNF
35 11.89 CSF2 IL2RA TNF
36 11.88 CSF2 IFNG TNF
37 11.88 CSF2 ICAM1 IFNG IL2
38 11.88 CCL2 CCL5 CSF2 CXCL5 ICAM1 TNF
39 11.83 CSF2 IFNG IL18
40 11.82 CSF2 IFNG IL2 TNF
41
Show member pathways
11.82 CSF2 IFNG IL2 IL2RA TNF
42 11.74 CCL2 CCL5 CSF2 TNF
43
Show member pathways
11.72 IFNG IL2 IL2RA TNF
44 11.71 ICAM1 IL2RA TNF
45
Show member pathways
11.69 CSF2 ICAM1 IFNG IL2 TNF
46 11.61 CCL2 IFNG IL18 TNF
47 11.6 IFNG IL2 TNF
48 11.57 IFNG IL2 TNF
49 11.55 IFNG IL2 IL2RA
50 11.54 CXCR3 IFNG IL18 IL2 IL2RA TNF

GO Terms for Pulmonary Sarcoidosis

Cellular components related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ACE CCL2 CCL5 CSF2 CXCL5 IFNG
2 cell surface GO:0009986 9.65 CCR5 CXCR3 ICAM1 IL2RA TNF
3 external side of plasma membrane GO:0009897 9.43 ACE CCR5 CXCR3 ICAM1 IL2RA TNF
4 extracellular space GO:0005615 9.36 ACE CCL2 CCL5 CSF2 CXCL5 ICAM1

Biological processes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.96 CCL5 CCR5 CXCL5 IL18 IL2
2 cell surface receptor signaling pathway GO:0007166 9.92 CCL2 CCR5 CXCR3 IFNG IL2RA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 CCL5 ICAM1 TNF
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 CCR5 CXCR3 IL2
5 cellular response to tumor necrosis factor GO:0071356 9.87 CCL2 CCL5 ICAM1
6 response to virus GO:0009615 9.86 CCL5 IFNG TNF
7 regulation of receptor activity GO:0010469 9.86 CCL2 CCL5 CSF2 CXCL5 IFNG IL18
8 chemotaxis GO:0006935 9.85 CCL2 CCL5 CCR5 CXCL5 CXCR3
9 cellular response to interferon-gamma GO:0071346 9.84 CCL2 CCL5 ICAM1
10 cellular response to interleukin-1 GO:0071347 9.83 CCL2 CCL5 ICAM1
11 cell chemotaxis GO:0060326 9.83 CCL2 CCL5 CXCL5
12 regulation of insulin secretion GO:0050796 9.83 CCL5 IFNG TNF
13 cellular response to lipopolysaccharide GO:0071222 9.83 CCL2 CCR5 CSF2 ICAM1 TNF
14 positive regulation of T cell proliferation GO:0042102 9.82 CCL5 IL2 IL2RA
15 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 CCL5 IL18 TNF
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 CCL5 IL18 TNF
17 humoral immune response GO:0006959 9.79 CCL2 IFNG TNF
18 protein kinase B signaling GO:0043491 9.77 CCL2 CCL5 TNF
19 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL2 TNF
20 chemokine-mediated signaling pathway GO:0070098 9.77 CCL2 CCL5 CCR5 CXCL5 CXCR3
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 ICAM1 IFNG TNF
22 inflammatory response GO:0006954 9.76 CCL2 CCL5 CCR5 CXCL5 CXCR3 IL18
23 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CCL5 CSF2 IFNG IL18 IL2
24 positive regulation of activated T cell proliferation GO:0042104 9.71 IL18 IL2 IL2RA
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 CCL5 IL18 TNF
26 positive regulation of osteoclast differentiation GO:0045672 9.7 IFNG TNF
27 positive regulation of T cell differentiation GO:0045582 9.69 IL2 IL2RA
28 dendritic cell chemotaxis GO:0002407 9.69 CCL5 CCR5
29 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 CSF2 IL18
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IFNG TNF
31 positive regulation of interleukin-17 production GO:0032740 9.68 IL18 IL2
32 positive regulation of podosome assembly GO:0071803 9.67 CSF2 TNF
33 neutrophil activation GO:0042119 9.67 CCL5 IL18
34 regulation of regulatory T cell differentiation GO:0045589 9.67 IFNG IL2 IL2RA
35 neutrophil mediated immunity GO:0002446 9.66 ACE CXCL5
36 macrophage chemotaxis GO:0048246 9.65 CCL2 CCL5 SFTPD
37 negative regulation of macrophage apoptotic process GO:2000110 9.64 CCL5 CCR5
38 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 ICAM1 TNF
39 negative regulation of lymphocyte proliferation GO:0050672 9.63 IL2 IL2RA
40 positive regulation of tissue remodeling GO:0034105 9.63 IL18 IL2
41 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IFNG
42 regulation of T cell homeostatic proliferation GO:0046013 9.58 IL2 IL2RA
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IFNG TNF
44 MAPK cascade GO:0000165 9.56 CCL2 CCL5 CCR5 CSF2 IL18 IL2
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.55 IFNG TNF
46 immune response GO:0006955 9.32 CCL2 CCL5 CCR5 CSF2 CXCL5 IFNG
47 G-protein coupled receptor signaling pathway GO:0007186 10.16 CCL2 CCL5 CCR5 CXCL5 CXCR3 IL2
48 positive regulation of gene expression GO:0010628 10 CSF2 IFNG IL18 TNF

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 CSF2 IL2 IL2RA
2 cytokine activity GO:0005125 9.23 CCL2 CCL5 CSF2 CXCL5 IFNG IL18
3 chemokine activity GO:0008009 9.13 CCL2 CCL5 CXCL5

Sources for Pulmonary Sarcoidosis

3 CDC
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10 dbSNP
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16 ExPASy
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