MCID: PLM012
MIFTS: 55

Pulmonary Sarcoidosis malady

Immune diseases, Respiratory diseases categories

Summaries for Pulmonary Sarcoidosis

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MalaCards: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to sarcoidosis and pulmonary fibrosis. An important gene associated with Pulmonary Sarcoidosis is IFNA10 (interferon, alpha 10), and among its related pathways are Cytokine Network and Allograft rejection. The compounds endotoxin and tarc have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Pulmonary Sarcoidosis

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8Disease Ontology, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Respiratory diseases


Aliases & Descriptions:

pulmonary sarcoidosis 8 30
sarcoidosis, pulmonary 60
sarcoidosis pulmonary 44
lung sarcoidosis 8


External Ids:

Disease Ontology8 DOID:13406
NCIt39 C34997
SNOMED-CT56 187230004, 24369008
MeSH34 D017565
ICD1025 D86.0, D86.2

Related Diseases for Pulmonary Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.9IL9, CCL3, CXCL9, CXCR6, CXCL5, CXCR3
2pulmonary fibrosis30.7CXCR3, SFTPD, CCL3
3tuberculosis30.6CCL3, SFTPD, CD69, CXCR3, CXCL9
4idiopathic pulmonary fibrosis30.6CCL3, SFTPD, SCGB1A1, CXCR3, CXCL5, CXCL9
5pneumonia30.4CCL3, SFTPD, SCGB1A1, CXCL5, MMP12
6systemic lupus erythematosus30.4CCL3, CD69, CD27, CXCR3
7lung cancer30.4SFTPD, SCGB1A1, CXCR3, IL9, MMP12
8arthritis30.3CCL3, CD69, CXCR3, CXCL5, CXCL9, MMP12
9glomerulonephritis30.3CXCL9, SCGB1A1
10cystic fibrosis30.1IL9, SCGB1A1, SFTPD
11rheumatoid arthritis30.1CCL3, SFTPD, GZMA, CD69, CD27, CXCR3
12multiple sclerosis30.1CCL3, SCGB1A1, CD69, CD27, CXCR3, CXCL9
13breast cancer30.1CCL3, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
14bronchiolitis29.9CCL3
15interstitial lung disease29.9SFTPD
16psoriasis29.9CD69, CXCR3, CXCL9
17extrinsic allergic alveolitis29.9CCL3, SFTPD, CXCR3
18influenza29.9CXCL9, CXCR3, CD27, CD69, SFTPD
19leukemia29.9CCL3, GZMA, SCGB1A1, CD27, CXCR3, IL9
20pulmonary emphysema29.9MMP12, SFTPD
21adenocarcinoma29.9MMP12, SCGB1A1, SFTPD
22bronchiolitis obliterans29.9CXCR3, SCGB1A1
23pulmonary tuberculosis10.4
24cardiac sarcoidosis10.3
25lupus erythematosus10.3
26ankylosing spondylitis10.2
27spondylitis10.2
28focal segmental glomerulosclerosis10.1
29membranoproliferative glomerulonephritis10.1
30skin sarcoidosis10.1
31focal glomerulosclerosis10.1
32amyloidosis10.1
33hypertension10.1
34mediastinitis10.1
35hepatitis b10.0IFNA17
36hepatitis c10.0IFNA17, CXCR3, CXCR6
37dermatitis10.0CXCL9, CXCR3
38inflammatory bowel disease10.0CCL25
39endometriosis10.0CXCL5, CD69
40eosinophilia10.0CD69, IL9
41uveitis10.0CD69, CXCR3, CXCL9, IL9
42multiple myeloma10.0CCL3
43graves' disease10.0CXCR3, CD69
44nephritis10.0CXCR3, SCGB1A1
45pulmonary disease, chronic obstructive10.0CCL3, SFTPD, SCGB1A1, CXCR3, IL9, MMP12
46atherosclerosis10.0CCL15, CXCR3, CXCR6, CXCL9, MMP12
47allergic asthma10.0CCL3, SFTPD, SCGB1A1, CD69, IL9
48myeloma10.0CCL3, CD27
49melanoma10.0CCL3, GZMA, CD27, CXCR3, CXCL5, CXCL9
50osteoarthritis10.0CCL3, GZMA, CXCR3, CXCL5, MMP12

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Clinical Features for Pulmonary Sarcoidosis

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Drugs & Therapeutics for Pulmonary Sarcoidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Search CenterWatch for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

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Anatomical Context for Pulmonary Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Sarcoidosis:

32
Lung, T cells, Lymph node, Testes, Monocytes, Breast, Skin, Myeloid, Nk cells, Eye, Liver, Heart, Spleen, Bone, Endothelial

Animal Models for Pulmonary Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.3CCL3, SFTPD, GZMA, CD69, CD27, IL9
2MP:000538710.0MMP12, CCL25, CCL3, SFTPD, GZMA, SCGB1A1

Publications for Pulmonary Sarcoidosis

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Sources:
50PubMed
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Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Accuracy of Individual Variables in the Monitoring of Long-term Change in Pulmonary Sarcoidosis as Judged by Serial High-Resolution CT Scan Data. (24051950)
2014
2
Pulmonary fibrosis in sarcoidosis. Clinical features and outcomes. (23952859)
2013
3
Correction: Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers. (24349580)
2013
4
Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests. (24339447)
2013
5
Sarcoidosis following sputum positive pulmonary tuberculosis: a rare entity. (22470222)
2012
6
CT features of primary systemic pulmonary amyloidosis mimicking pulmonary sarcoidosis. (21795014)
2012
7
Pulmonary sarcoidosis developing fatal interstitial pneumonia-like lesions: a case report and literature review. (21191822)
2011
8
A rare case of pulmonary tuberculosis with simultaneous pulmonary and skin sarcoidosis: a case report. (20205764)
2010
9
Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyping as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek patients. (20722470)
2010
10
Optic neuropathy, renal failure and pulmonary sarcoidosis in a 50-year-old man: where is the link? (21931581)
2009
11
The clinical and radiologic features of nodular pulmonary sarcoidosis. (18843518)
2009
12
Tumor-like pulmonary sarcoidosis diagnosed by CT-guided transthoracic lung biopsy. (19829830)
2009
13
Histological findings of the computed tomography halo in pulmonary sarcoidosis. (19567613)
2009
14
Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. (19218675)
2008
15
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
16
Guidelines for the use of corticosteroids in the treatment of pulmonary sarcoidosis. (17521216)
2007
17
Perforin down-regulation and adhesion molecules activation in pulmonary sarcoidosis: an induced sputum and BAL study. (16778280)
2006
18
Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. (16315781)
2005
19
Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses. (14528880)
2003
20
Angiotensin-converting enzyme gene polymorphisms in patients with pulmonary sarcoidosis: impact on disease severity. (12930157)
2003
21
Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis. (14665489)
2003
22
Extended genetic alterations in a patient with pulmonary sarcoidosis, a benign disease. (11587105)
2001
23
Right upper quadrant pain and fever in a patient with pulmonary sarcoidosis. (11436579)
2001
24
Corticosteroids for pulmonary sarcoidosis. (11034698)
2000
25
Correlation of CD4:CD8 ratio and tumour necrosis factor (TNF)alpha levels in induced sputum with bronchoalveolar lavage fluid in pulmonary sarcoidosis. (10899249)
2000
26
Microsatellite DNA instability and loss of heterozygosity in pulmonary sarcoidosis. (10556148)
1999
27
Lung transplantation for end-stage pulmonary sarcoidosis. (10207947)
1999
28
Immunohistochemical localization of B7 costimulating molecules and major histocompatibility complex class II antigen in pulmonary sarcoidosis. (10461083)
1999
29
An approach to the treatment of pulmonary sarcoidosis with corticosteroids: the six phases of treatment. (10208222)
1999
30
Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (10092696)
1999
31
Efficacy of azathioprine as second-line treatment in pulmonary sarcoidosis. (10207946)
1999
32
Medium term results of lung transplantation for end stage pulmonary sarcoidosis. (9741371)
1998
33
Membranoproliferative glomerulonephritis associated pulmonary sarcoidosis. (9481751)
1998
34
Pulmonary sarcoidosis mimicking cryptogenic fibrosing alveolitis on CT. (8937326)
1996
35
Bullous emphysema occurring in pulmonary sarcoidosis. (8560098)
1995
36
Treatment of cutaneous and pulmonary sarcoidosis with thalidomide. (7722046)
1995
37
Aspecific bronchial hyperreactivity in pulmonary sarcoidosis. (7809495)
1994
38
Accumulation of multiple T cell clonotypes in lungs of healthy individuals and patients with pulmonary sarcoidosis. (8120402)
1994
39
TCR expression of activated T cell clones in the lungs of patients with pulmonary sarcoidosis. (7930629)
1994
40
Standardized quantitative 67Ga scintigraphy in relation to carbon monoxide diffusion capacity in pulmonary sarcoidosis. (8134713)
1993
41
Role of high-resolution CT in the diagnosis and evaluation of pulmonary sarcoidosis. (8140324)
1993
42
Pulmonary sarcoidosis in children: serial evaluation of bronchoalveolar lavage cells during corticosteroid treatment. (8414740)
1993
43
Oxygen radical formation in pulmonary sarcoidosis. The signs of early macrophage activation]. (1597116)
1992
44
Influences of the cellular and humoral immune system in bronchoalveolar lavage on lung function in pulmonary sarcoidosis. (1620987)
1992
45
Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis. (1680610)
1991
46
Inhaled corticosteroid therapy in pulmonary sarcoidosis. (1669984)
1991
47
Pulmonary vascular involvement in sarcoidosis: granulomatous angiitis and microangiopathy in transbronchial lung biopsies. (1850897)
1991
48
Leukocyte integrins and their ligands: their possible role in the pathogenesis of pulmonary sarcoidosis. (1669987)
1991
49
Glucocorticoid receptor mRNA expression in pulmonary alveolar macrophages in sarcoidosis. (2036813)
1991
50
Comparison of alveolar macrophage and blood monocyte oxidative burst response in pulmonary sarcoidosis. (2162680)
1990

Genetic Variations for Pulmonary Sarcoidosis

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Expression for genes affiliated with Pulmonary Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IFNA10, IFNA17, IL9
2
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10.4IL9, IFNA17, IFNA10, CCL25
3
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10.4CXCL9, IFNA17, IFNA10, CCL3
4
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10.4CCL25, CCL15, CCL23, CCL3, IFNA10, IFNA17
510.4CCL25, CCL3, CXCR3, CXCL5, CXCR6, CXCL9
6
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10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
7
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10.3CCL25, IL9, CXCL9, CXCR6, CXCL5, CXCR3
8
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10.3CXCL9, CXCR6, CXCL5, CXCR3, CCL3, CCL23
9
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10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
10
Hide members
10.3CCL25, CCL23, CCL3, GZMA, CXCR3, CXCL5
11
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
12
Hide members
10.3IL9, CCL25, CCL15, CCL23, CCL3, IFNA10

Compounds for genes affiliated with Pulmonary Sarcoidosis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.8SCGB1A1, CXCR3, CXCL5
2tarc4410.8CCL3, CXCR3, CXCL5, CXCL9, IL9
3rantes4410.8IL9, CXCR6, CXCL5, CXCR3, GZMA, CCL3
4ccl444 2811.7CCL15, CCL3, CXCR3, CXCL5, CXCL9
5ccl344 2811.7CCL15, CCL23, CCL3, CXCR3, CXCL5, CXCL9
6dexamethasone44 49 28 1113.7MMP12, CXCL9, GREM1, SFTPD
7allergens4410.7IL9, CXCR3, CD69, SFTPD
8groalpha4410.7CCL3, CXCR3, CXCL5, CXCL9
9ena 784410.7CXCL5, CXCL9
10histamine44 28 2412.7CCL3, SFTPD, CXCR3, CXCL9, IL9
11nitric oxide44 11 2412.7CCL3, SFTPD, SCGB1A1, CD69, CXCR3, CXCL5
12ionomycin4410.7CCL3, GZMA, CD69, CXCR6, CXCL9, IL9
13oxygen44 2411.7MMP12, SCGB1A1, GZMA, SFTPD, CCL3
14fmlp4410.6CXCL5, CXCR3, CD69, CCL3
15il 104410.6CXCL9, CXCR3, CCL3
16serine4410.6CCL3, CD69, CXCR3, IL9, MMP12
17calcium44 49 11 2413.6GZMA, SFTPD, CCL3, CCL23, CCL15, CCL25
18phosphatidylinositol4410.6SFTPD, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
19thymidine44 2411.5CCL3, SFTPD, CD69, CXCR3, IL9
20tyrosine4410.5GZMA, GREM1, CD69, CXCR3, CXCL5, CXCL9
21larc4410.4CXCR3, CCL3
22cysteine4410.4CD27, GREM1, GZMA, SFTPD, CCL3, CCL15
23isopentenyl diphosphate44 2811.4CCL3, CD69
24teck4410.3CCL3, CCL25
25mcp 14410.1CXCR3, CCL3

GO Terms for genes affiliated with Pulmonary Sarcoidosis

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16Gene Ontology
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Cellular components related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4CXCL9, CXCR3, CD27, CD69
2extracellular spaceGO:00561510.2IL9, CCL25, CCL15, CCL23, CCL3, SFTPD
3extracellular regionGO:00557610.0IFNA10, SFTPD, CCL3, CCL23, CCL25, IFNA17

Biological processes related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.6CXCL9, CCL25, CCL15, CCL23, CCL3, CXCR3
2T cell chemotaxisGO:01081810.6CXCR3, CCL3
3inflammatory responseGO:00695410.5CCL25, CCL23, CCL3, CXCR3, CXCR6, CXCL9
4immune responseGO:00695510.5CCL25, CCL15, CCL23, GZMA, CXCL5, CXCR6
5cell-cell signalingGO:00726710.5CCL15, CCL23, CCL3, GREM1, CXCL5, CXCL9
6cellular calcium ion homeostasisGO:00687410.5CCL15, CCL23, CCL3
7macrophage chemotaxisGO:04824610.4SFTPD, CCL3
8negative regulation of bone mineralizationGO:03050210.4GREM1, CCL3
9G-protein coupled receptor signaling pathwayGO:00718610.3CCL25, CCL23, CXCR6, CXCL9
10monocyte chemotaxisGO:00254810.1CCL3, CCL23

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.4CCL3, CCL15
2chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3, CCL23, CCL15, CCL25
3cytokine activityGO:00512510.4IFNA10, IFNA17, GREM1, CXCL9, IL9
4CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL23
5C-X-C chemokine receptor activityGO:01649410.2CXCR6, CXCR3

Products for genes affiliated with Pulmonary Sarcoidosis

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Sources for Pulmonary Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet