MCID: PLM012
MIFTS: 52

Pulmonary Sarcoidosis malady

Immune, Respiratory categories

Summaries for Pulmonary Sarcoidosis

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33MalaCards
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MalaCards: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to tuberculosis and idiopathic pulmonary fibrosis. An important gene associated with Pulmonary Sarcoidosis is IFNA10 (interferon, alpha 10), and among its related pathways are Cytokine Network and Allograft rejection. The compounds endotoxin and tarc have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Pulmonary Sarcoidosis

Sources:
8Disease Ontology, 31LifeMap Discovery™, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Respiratory


Aliases & Descriptions:

pulmonary sarcoidosis 8 31
sarcoidosis, pulmonary 61
sarcoidosis pulmonary 45
lung sarcoidosis 8


External Ids:

Disease Ontology8 DOID:13406
NCIt40 C34997
SNOMED-CT57 187230004, 24369008
MeSH35 D017565
ICD1025 D86.0, D86.2

Related Diseases for Pulmonary Sarcoidosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.6CCL3, SFTPD, CD69, CXCR3, CXCL9
2idiopathic pulmonary fibrosis30.6CCL3, SFTPD, SCGB1A1, CXCR3, CXCL5, CXCL9
3systemic lupus erythematosus30.4CCL3, CD69, CD27, CXCR3
4arthritis30.3CCL3, CD69, CXCR3, CXCL5, CXCL9, MMP12
5cystic fibrosis30.2IL9, SCGB1A1, SFTPD
6bronchiolitis29.9CCL3
7atopy29.9SCGB1A1, CXCR3, IL9
8adenocarcinoma29.9MMP12, SCGB1A1, SFTPD
9bronchiolitis obliterans29.9CXCR3, SCGB1A1
10pulmonary function10.6
11pulmonary tuberculosis10.4
12sarcoidosis 110.4
13cardiac sarcoidosis10.3
14ankylosing spondylitis10.2
15spondylitis10.2
16focal segmental glomerulosclerosis10.1
17membranoproliferative glomerulonephritis10.1
18skin sarcoidosis10.1
19focal glomerulosclerosis10.1
20amyloidosis10.1
21sarcoidosis 210.1
22hepatitis b10.0IFNA17
23interstitial lung disease10.0SFTPD
24hepatitis c10.0IFNA17, CXCR3, CXCR6
25pulmonary fibrosis10.0CXCR3, SFTPD, CCL3
26dermatitis10.0CXCL9, CXCR3
27inflammatory bowel disease10.0CCL25
28endometriosis10.0CXCL5, CD69
29eosinophilia10.0CD69, IL9
30uveitis10.0CD69, CXCR3, CXCL9, IL9
31multiple myeloma10.0CCL3
32psoriasis10.0CD69, CXCR3, CXCL9
33graves' disease10.0CXCR3, CD69
34extrinsic allergic alveolitis10.0CCL3, SFTPD, CXCR3
35nephritis10.0CXCR3, SCGB1A1
36pulmonary disease, chronic obstructive10.0CCL3, SFTPD, SCGB1A1, CXCR3, IL9, MMP12
37adenoma10.0
38influenza10.0CXCL9, CXCR3, CD27, CD69, SFTPD
39atherosclerosis10.0CCL15, CXCR3, CXCR6, CXCL9, MMP12
40pneumonia10.0CCL3, SFTPD, SCGB1A1, CXCL5, MMP12
41allergic asthma10.0CCL3, SFTPD, SCGB1A1, CD69, IL9
42myeloma10.0CCL3, CD27
43melanoma10.0CCL3, GZMA, CD27, CXCR3, CXCL5, CXCL9
44osteoarthritis10.0CCL3, GZMA, CXCR3, CXCL5, MMP12
45inclusion body myositis10.0CXCL9, CXCR3
46glomerulonephritis10.0CXCL9, SCGB1A1
47leukemia10.0CCL3, GZMA, SCGB1A1, CD27, CXCR3, IL9
48sepsis10.0CCL3, SFTPD, GZMA, CD69, CXCL5, CXCL9
49atopic dermatitis10.0IL9, CXCL9, CXCR3, CD69
50hepatocellular carcinoma10.0CCL15, CXCL9, MMP12

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Clinical Features for Pulmonary Sarcoidosis

Drugs & Therapeutics for Pulmonary Sarcoidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Search CenterWatch for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

Anatomical Context for Pulmonary Sarcoidosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Sarcoidosis:

33
Skin, Liver, Lymph node, Lung, Spleen, Heart, Small intestine, Breast, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Pulmonary Sarcoidosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.3CCL3, SFTPD, GZMA, CD69, CD27, IL9
2MP:000538710.0MMP12, CCL25, CCL3, SFTPD, GZMA, SCGB1A1

Publications for Pulmonary Sarcoidosis

Sources:
51PubMed
See all sources

Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Peroxisome proliferator-activated receptor gamma as modulator of inflammation in pulmonary sarcoidosis. (24364239)
2013
2
Combined pulmonary involvement in hereditary lysozyme amyloidosis with associated pulmonary sarcoidosis: a case report. (24351625)
2013
3
Use of discriminant analysis in assessing pulmonary function worsening in patients with sarcoidosis by a panel of inflammatory biomarkers. (23262919)
2013
4
Nodular pulmonary sarcoidosis. (22808628)
2012
5
Prognostic value of dual-time-point 18F-fluorodeoxyglucose positron emission tomography in patients with pulmonary sarcoidosis. (21382131)
2011
6
Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? (21834618)
2011
7
18F-FDG PET as a predictor of pulmonary function in sarcoidosis. (22117503)
2011
8
Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. (19218196)
2009
9
Pulmonary sarcoidosis simulating metastatic breast cancer. (18923207)
2008
10
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
11
The pathology of pulmonary sarcoidosis: update. (17882899)
2007
12
Pulmonary sarcoidosis with usual interstitial pneumonia distributed predominantly in the lower lung fields. (16617185)
2006
13
Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. (16507843)
2006
14
Pulmonary sarcoidosis and antiphospholipid syndrome. (16771926)
2006
15
Lung transplantation for end-stage pulmonary sarcoidosis: outcome in a series of seven consecutive patients. (16315786)
2005
16
Cardiac involvement in patients with pulmonary sarcoidosis assessed at two university medical centers in the Netherlands. (16002912)
2005
17
Severe pulmonary sarcoidosis is strongly associated with the haplotype HLA-DQB1*0602-DRB1*150101. (16112030)
2005
18
Long-term follow-up CT scan evaluation in patients with pulmonary sarcoidosis. (15653982)
2005
19
Trends and occupational associations in incidence of hospitalized pulmonary sarcoidosis and other lung diseases in Navy personnel: a 27-year historical prospective study, 1975-2001. (15539709)
2004
20
Long-term use of corticosteroid eye drops delays the spontaneous remission of pulmonary sarcoidosis. (15109125)
2004
21
Diagnostic relevance of Langerin detection in cells from bronchoalveolar lavage of patients with pulmonary Langerhans cell histiocytosis, sarcoidosis and idiopathic pulmonary fibrosis. (14722767)
2004
22
Increased spontaneous interleukin-10 release from alveolar macrophages in active pulmonary sarcoidosis. (12746045)
2003
23
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
24
CC and C chemokine expression in pulmonary sarcoidosis. (12449175)
2002
25
Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. (11828047)
2002
26
Radiology quiz case. Nasal sarcoidosis, in association with pulmonary sarcoidosis. (12162783)
2002
27
Ultrastructural study of expression of adhesion molecules between blood monocytes and alveolar macrophages from patients with pulmonary sarcoidosis. (11989775)
2001
28
Biopsy diagnosis of disease recurrence after transplantation (TX) for pulmonary sarcoidosis: a multicentre study. (11250219)
2001
29
Recurrent pulmonary sarcoidosis in HIV-infected patients receiving highly active antiretroviral therapy. (11243991)
2001
30
Inhaled corticosteroids for maintenance treatment in childhood pulmonary sarcoidosis. (11529550)
2001
31
Clinical aspects of pulmonary sarcoidosis. (10670174)
2000
32
HLA-A, B, C antigens in pulmonary sarcoidosis in Polish population. (11729830)
1999
33
Oral prednisolone followed by inhaled budesonide in newly diagnosed pulmonary sarcoidosis: a double-blind, placebo-controlled multicenter study. Finnish Pulmonary Sarcoidosis Study Group. (10453872)
1999
34
Sarcoidosis: correlation of HRCT findings with results of pulmonary function tests and serum angiotensin-converting enzyme assay. (9787595)
1998
35
A simple radiographic scoring method for monitoring pulmonary sarcoidosis: relations between radiographic scores, dyspnoea grade and respiratory function in the British Thoracic Society Study of Long-Term Corticosteroid Treatment. (9186989)
1997
36
HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis. (9372682)
1997
37
Effectiveness of Tc-99m sestamibi compared to Ga-67 in patients with pulmonary sarcoidosis. (9363381)
1997
38
Th1/Th2 cell distribution in pulmonary sarcoidosis. (9032124)
1997
39
Pulmonary sarcoidosis: patterns of cytokine release in vitro. (8834333)
1996
40
Endothelin-1 excretion in urine in active pulmonary sarcoidosis and in other interstitial lung diseases. (8532958)
1995
41
Single lung transplantation involving a donor with documented pulmonary sarcoidosis. (7947890)
1994
42
Absolute quantitation of gallium-67 citrate accumulation in the lungs and its importance for the evaluation of disease activity in pulmonary sarcoidosis. (1334468)
1992
43
Tumour-like presentation of pulmonary sarcoidosis. (1486978)
1992
44
Evaluation of cellular immunity in pulmonary sarcoidosis and primary lung cancer]. (1327551)
1992
45
Endometrial and pulmonary sarcoidosis. (1506159)
1992
46
Preferential usage of the T-cell antigen receptor beta-chain constant region C beta 1 element by lung T-lymphocytes of patients with pulmonary sarcoidosis. (1848052)
1991
47
In pulmonary sarcoidosis ciliated bronchial epithelial cells show increased HLA-DR antigens expression which is not associated with antigen presenting ability in the mixed leukocyte reaction. (1669988)
1991
48
Lung mechanics and gas exchange in steroid treated pulmonary sarcoidosis. A seven year follow-up. (1669974)
1991
49
Lymphocytic hypophysitis and pulmonary sarcoidosis. Report of a case. (2014777)
1991
50
Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis. (2110187)
1990

Genetic Variations for Pulmonary Sarcoidosis

Expression for genes affiliated with Pulmonary Sarcoidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IFNA10, IFNA17, IL9
2
Hide members
10.4IL9, IFNA17, IFNA10, CCL25
3
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10.4CXCL9, IFNA17, IFNA10, CCL3
4
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10.4CCL25, CCL15, CCL23, CCL3, IFNA10, IFNA17
510.4CCL25, CCL3, CXCR3, CXCL5, CXCR6, CXCL9
6
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
7
Hide members
10.3CCL25, IL9, CXCL9, CXCR6, CXCL5, CXCR3
8
Hide members
10.3CXCL9, CXCR6, CXCL5, CXCR3, CCL3, CCL23
9
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
10
Hide members
10.3CCL25, CCL23, CCL3, GZMA, CXCR3, CXCL5
11
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
12
Hide members
10.3IL9, CCL25, CCL15, CCL23, CCL3, IFNA10

Compounds for genes affiliated with Pulmonary Sarcoidosis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.8SCGB1A1, CXCR3, CXCL5
2tarc4510.8CCL3, CXCR3, CXCL5, CXCL9, IL9
3rantes4510.8IL9, CXCR6, CXCL5, CXCR3, GZMA, CCL3
4ccl445 2911.7CCL15, CCL3, CXCR3, CXCL5, CXCL9
5ccl345 2911.7CCL15, CCL23, CCL3, CXCR3, CXCL5, CXCL9
6dexamethasone45 50 29 1113.7MMP12, CXCL9, GREM1, SFTPD
7allergens4510.7IL9, CXCR3, CD69, SFTPD
8groalpha4510.7CCL3, CXCR3, CXCL5, CXCL9
9ena 784510.7CXCL5, CXCL9
10histamine45 29 2412.7CCL3, SFTPD, CXCR3, CXCL9, IL9
11nitric oxide45 11 2412.7CCL3, SFTPD, SCGB1A1, CD69, CXCR3, CXCL5
12ionomycin4510.7CCL3, GZMA, CD69, CXCR6, CXCL9, IL9
13oxygen45 2411.7MMP12, SCGB1A1, GZMA, SFTPD, CCL3
14fmlp4510.6CXCL5, CXCR3, CD69, CCL3
15il 104510.6CXCL9, CXCR3, CCL3
16serine4510.6CCL3, CD69, CXCR3, IL9, MMP12
17calcium45 50 11 2413.6GZMA, SFTPD, CCL3, CCL23, CCL15, CCL25
18phosphatidylinositol4510.6SFTPD, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
19thymidine45 2411.5CCL3, SFTPD, CD69, CXCR3, IL9
20tyrosine4510.5GZMA, GREM1, CD69, CXCR3, CXCL5, CXCL9
21larc4510.4CXCR3, CCL3
22cysteine4510.4CD27, GREM1, GZMA, SFTPD, CCL3, CCL15
23isopentenyl diphosphate45 2911.4CCL3, CD69
24teck4510.3CCL3, CCL25
25mcp 14510.1CXCR3, CCL3

GO Terms for genes affiliated with Pulmonary Sarcoidosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4CXCL9, CXCR3, CD27, CD69
2extracellular spaceGO:00561510.2CXCL5, CXCL9, GREM1, SCGB1A1, IFNA17, IFNA10
3extracellular regionGO:00557610.0ADAMDEC1, CCL25, MMP12, CXCL9, CXCL5, CD27

Biological processes related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.6CXCL9, CCL25, CCL15, CCL23, CCL3, CXCR3
2T cell chemotaxisGO:01081810.6CXCR3, CCL3
3inflammatory responseGO:00695410.5CCL25, CCL23, CCL3, CXCR3, CXCR6, CXCL9
4immune responseGO:00695510.5CCL25, CCL15, CCL23, GZMA, CXCL5, CXCR6
5cell-cell signalingGO:00726710.5CCL15, CCL23, CCL3, GREM1, CXCL5, CXCL9
6cellular calcium ion homeostasisGO:00687410.5CCL15, CCL23, CCL3
7macrophage chemotaxisGO:04824610.4SFTPD, CCL3
8negative regulation of bone mineralizationGO:03050210.4GREM1, CCL3
9G-protein coupled receptor signaling pathwayGO:00718610.3CCL25, CCL23, CXCR6, CXCL9
10monocyte chemotaxisGO:00254810.1CCL3, CCL23

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.4CCL3, CCL15
2chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3, CCL23, CCL15, CCL25
3cytokine activityGO:00512510.4IFNA10, IFNA17, GREM1, CXCL9, IL9
4CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL23
5C-X-C chemokine receptor activityGO:01649410.2CXCR6, CXCR3

Products for genes affiliated with Pulmonary Sarcoidosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Sarcoidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet