MCID: PLM012
MIFTS: 55

Pulmonary Sarcoidosis malady

Immune diseases, Respiratory diseases categories

Summaries for Pulmonary Sarcoidosis

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32MalaCards
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MalaCards: Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to sarcoidosis and pulmonary fibrosis. An important gene associated with Pulmonary Sarcoidosis is IFNA10 (interferon, alpha 10), and among its related pathways are Cytokine Network and Allograft rejection. The compounds endotoxin and tarc have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Pulmonary Sarcoidosis

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Respiratory diseases


Aliases & Descriptions:

pulmonary sarcoidosis 8 30
sarcoidosis, pulmonary 60
sarcoidosis pulmonary 44
lung sarcoidosis 8


External Ids:

Disease Ontology8 DOID:13406
NCIt39 C34997
SNOMED-CT56 187230004, 24369008
MeSH34 D017565
ICD1025 D86.0, D86.2

Related Diseases for Pulmonary Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.9IL9, CCL3, CXCL9, CXCR6, CXCL5, CXCR3
2pulmonary fibrosis30.7CXCR3, SFTPD, CCL3
3tuberculosis30.6CCL3, SFTPD, CD69, CXCR3, CXCL9
4idiopathic pulmonary fibrosis30.6CCL3, SFTPD, SCGB1A1, CXCR3, CXCL5, CXCL9
5pneumonia30.4CCL3, SFTPD, SCGB1A1, CXCL5, MMP12
6systemic lupus erythematosus30.4CCL3, CD69, CD27, CXCR3
7lung cancer30.4SFTPD, SCGB1A1, CXCR3, IL9, MMP12
8arthritis30.3CCL3, CD69, CXCR3, CXCL5, CXCL9, MMP12
9glomerulonephritis30.3CXCL9, SCGB1A1
10cystic fibrosis30.1IL9, SCGB1A1, SFTPD
11rheumatoid arthritis30.1CCL3, SFTPD, GZMA, CD69, CD27, CXCR3
12multiple sclerosis30.1CCL3, SCGB1A1, CD69, CD27, CXCR3, CXCL9
13breast cancer30.1CCL3, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
14bronchiolitis29.9CCL3
15interstitial lung disease29.9SFTPD
16psoriasis29.9CD69, CXCR3, CXCL9
17extrinsic allergic alveolitis29.9CCL3, SFTPD, CXCR3
18influenza29.9CXCL9, CXCR3, CD27, CD69, SFTPD
19leukemia29.9CCL3, GZMA, SCGB1A1, CD27, CXCR3, IL9
20pulmonary emphysema29.9MMP12, SFTPD
21adenocarcinoma29.9MMP12, SCGB1A1, SFTPD
22bronchiolitis obliterans29.9CXCR3, SCGB1A1
23pulmonary tuberculosis10.4
24cardiac sarcoidosis10.3
25lupus erythematosus10.3
26ankylosing spondylitis10.2
27spondylitis10.2
28focal segmental glomerulosclerosis10.1
29membranoproliferative glomerulonephritis10.1
30skin sarcoidosis10.1
31focal glomerulosclerosis10.1
32amyloidosis10.1
33hypertension10.1
34mediastinitis10.1
35hepatitis b10.0IFNA17
36hepatitis c10.0IFNA17, CXCR3, CXCR6
37dermatitis10.0CXCL9, CXCR3
38inflammatory bowel disease10.0CCL25
39endometriosis10.0CXCL5, CD69
40eosinophilia10.0CD69, IL9
41uveitis10.0CD69, CXCR3, CXCL9, IL9
42multiple myeloma10.0CCL3
43graves' disease10.0CXCR3, CD69
44nephritis10.0CXCR3, SCGB1A1
45pulmonary disease, chronic obstructive10.0CCL3, SFTPD, SCGB1A1, CXCR3, IL9, MMP12
46atherosclerosis10.0CCL15, CXCR3, CXCR6, CXCL9, MMP12
47allergic asthma10.0CCL3, SFTPD, SCGB1A1, CD69, IL9
48myeloma10.0CCL3, CD27
49melanoma10.0CCL3, GZMA, CD27, CXCR3, CXCL5, CXCL9
50osteoarthritis10.0CCL3, GZMA, CXCR3, CXCL5, MMP12

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to pulmonary sarcoidosis

Clinical Features for Pulmonary Sarcoidosis

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Drugs & Therapeutics for Pulmonary Sarcoidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Sarcoidosis

Search NIH Clinical Center for Pulmonary Sarcoidosis

Search CenterWatch for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for treatment of pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived stem cells, PMID: 22469567

Genetic Tests for Pulmonary Sarcoidosis

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Anatomical Context for Pulmonary Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Sarcoidosis:

32
Lung, T cells, Lymph node, Testes, Monocytes, Breast, Skin, Myeloid, Nk cells, Eye, Liver, Heart, Spleen, Bone, Endothelial

Animal Models for Pulmonary Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.3CCL3, SFTPD, GZMA, CD69, CD27, IL9
2MP:000538710.0MMP12, CCL25, CCL3, SFTPD, GZMA, SCGB1A1

Publications for Pulmonary Sarcoidosis

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50PubMed
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Articles related to Pulmonary Sarcoidosis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
sTREM-1 in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis, effect of smoking and inflammation. (24329508)
2013
2
Clinical characteristics, haemodynamics and treatment of pulmonary hypertension in sarcoidosis in a single centre, and meta-analysis of the published data. (23290599)
2013
3
Sarcoidosis-associated pulmonary hypertension. (23912192)
2013
4
Opposite behavior of plasma levels surfactant protein type B and receptor for advanced glycation end products in pulmonary sarcoidosis. (23948664)
2013
5
A case of pulmonary sarcoidosis with endobronchial nodular involvement. (23814600)
2013
6
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
7
Differential expression of microRNA and predicted targets in pulmonary sarcoidosis. (22209793)
2012
8
A case of pulmonary sarcoidosis preceding polycythemia vera with literature review. (20229031)
2012
9
Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids. (22494798)
2012
10
The treatment of pulmonary sarcoidosis. (22495110)
2012
11
T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis. (21540308)
2011
12
Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis. (20151281)
2010
13
Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression. (21059230)
2010
14
Pharmacotherapy for pulmonary sarcoidosis: a Delphi consensus study. (20089389)
2010
15
Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis]. (20979817)
2010
16
The six-minute walk test in patients with pulmonary sarcoidosis. (19561926)
2009
17
Management strategies for pulmonary sarcoidosis. (19707274)
2009
18
Phenotyping sarcoidosis from a pulmonary perspective. (17975200)
2008
19
The galaxy sign in pulmonary sarcoidosis. (18447132)
2008
20
Retraction: involvement of discoidin domain receptor 1 in the deterioration of pulmonary sarcoidosis. (18695263)
2008
21
Practical issues and challenges in the diagnosis and treatment of pulmonary sarcoidosis. (17209662)
2007
22
Non-invasive detection of latent cardiac conduction abnormalities in patients with pulmonary sarcoidosis. (17384456)
2007
23
The effect of thalidomide on corticosteroid-dependent pulmonary sarcoidosis. (16933470)
2006
24
Expression of CCX CKR in pulmonary sarcoidosis. (17109071)
2006
25
The additional value of gadolinium-enhanced MRI to standard assessment for cardiac involvement in patients with pulmonary sarcoidosis. (16162768)
2005
26
An increase in exhaled nitric oxide is not associated with activity in pulmonary sarcoidosis. (15459140)
2004
27
Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis. (14748748)
2003
28
Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis. (12917971)
2003
29
Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis. (12626344)
2003
30
Pulmonary sarcoidosis in children: a follow-up study. (11401056)
2001
31
Pulmonary sarcoidosis in a patient with essential thrombocythemia treated with interferon alpha: a short case report. (11208342)
2000
32
Nitric oxide levels in exhaled air and inducible nitric oxide synthase immunolocalization in pulmonary sarcoidosis. (10573228)
1999
33
Pulmonary sarcoidosis: calcified micronodular pattern simulating pulmonary alveolar microlithiasis. (10404510)
1999
34
Pulmonary sarcoidosis: comparison of patients at a university and a municipal hospital. (10388256)
1999
35
Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. (10572066)
1999
36
Pulmonary sarcoidosis and focal segmental glomerulosclerosis: case report and renal transplant follow-up. (9509472)
1998
37
Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? (9305302)
1997
38
Propeptide levels of type III and type I procollagen in the serum and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. (9493651)
1997
39
Fallopian tube and pulmonary sarcoidosis. A case report. (9284018)
1997
40
Limited heterogeneity of biased T-cell receptor V beta gene usage in lung but not blood T cells in active pulmonary sarcoidosis. (8881751)
1996
41
Shared amino acid motifs in T-cell receptor beta junctional regions of bronchoalveolar T cells in patients with pulmonary sarcoidosis. (8680698)
1996
42
Pulmonary sarcoidosis presenting as a granulomatous tattoo reaction. (8204477)
1994
43
Why perform high resolution computed tomography in pulmonary sarcoidosis? (8140309)
1993
44
Successful treatment of life-threatening steroid-resistant pulmonary sarcoidosis with cyclosporin in a patient with systemic lupus erythematosus. (2371427)
1990
45
Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with pulmonary sarcoidosis. (2341565)
1990
46
Fibrebronchoscopy in pulmonary sarcoidosis--an Indian experience. (2134230)
1990
47
Urinary neopterin in pulmonary sarcoidosis. Relationship to clinical and biologic assessment of the disease. (2543248)
1989
48
Systemic lupus erythematosus developing in a patient with longstanding pulmonary sarcoidosis. (2685296)
1989
49
Lung mechanics and their relationship to lung volumes in pulmonary sarcoidosis. (2776871)
1989
50
Membranoproliferative glomerulonephritis associated with pulmonary sarcoidosis. (3826138)
1986

Genetic Variations for Pulmonary Sarcoidosis

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Expression for genes affiliated with Pulmonary Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for genes affiliated with Pulmonary Sarcoidosis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IFNA10, IFNA17, IL9
2
Hide members
10.4IL9, IFNA17, IFNA10, CCL25
3
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10.4CXCL9, IFNA17, IFNA10, CCL3
4
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10.4CCL25, CCL15, CCL23, CCL3, IFNA10, IFNA17
510.4CCL25, CCL3, CXCR3, CXCL5, CXCR6, CXCL9
6
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10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
7
Hide members
10.3CCL25, IL9, CXCL9, CXCR6, CXCL5, CXCR3
8
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10.3CXCL9, CXCR6, CXCL5, CXCR3, CCL3, CCL23
9
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10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
10
Hide members
10.3CCL25, CCL23, CCL3, GZMA, CXCR3, CXCL5
11
Hide members
10.3CCL25, CCL15, CCL23, CCL3, CXCR3, CXCL5
12
Hide members
10.3IL9, CCL25, CCL15, CCL23, CCL3, IFNA10

Compounds for genes affiliated with Pulmonary Sarcoidosis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.8SCGB1A1, CXCR3, CXCL5
2tarc4410.8CCL3, CXCR3, CXCL5, CXCL9, IL9
3rantes4410.8IL9, CXCR6, CXCL5, CXCR3, GZMA, CCL3
4ccl444 2811.7CCL15, CCL3, CXCR3, CXCL5, CXCL9
5ccl344 2811.7CCL15, CCL23, CCL3, CXCR3, CXCL5, CXCL9
6dexamethasone44 49 28 1113.7MMP12, CXCL9, GREM1, SFTPD
7allergens4410.7IL9, CXCR3, CD69, SFTPD
8groalpha4410.7CCL3, CXCR3, CXCL5, CXCL9
9ena 784410.7CXCL5, CXCL9
10histamine44 28 2412.7CCL3, SFTPD, CXCR3, CXCL9, IL9
11nitric oxide44 11 2412.7CCL3, SFTPD, SCGB1A1, CD69, CXCR3, CXCL5
12ionomycin4410.7CCL3, GZMA, CD69, CXCR6, CXCL9, IL9
13oxygen44 2411.7MMP12, SCGB1A1, GZMA, SFTPD, CCL3
14fmlp4410.6CXCL5, CXCR3, CD69, CCL3
15il 104410.6CXCL9, CXCR3, CCL3
16serine4410.6CCL3, CD69, CXCR3, IL9, MMP12
17calcium44 49 11 2413.6GZMA, SFTPD, CCL3, CCL23, CCL15, CCL25
18phosphatidylinositol4410.6SFTPD, SCGB1A1, CD69, CXCR3, CXCL9, MMP12
19thymidine44 2411.5CCL3, SFTPD, CD69, CXCR3, IL9
20tyrosine4410.5GZMA, GREM1, CD69, CXCR3, CXCL5, CXCL9
21larc4410.4CXCR3, CCL3
22cysteine4410.4CD27, GREM1, GZMA, SFTPD, CCL3, CCL15
23isopentenyl diphosphate44 2811.4CCL3, CD69
24teck4410.3CCL3, CCL25
25mcp 14410.1CXCR3, CCL3

GO Terms for genes affiliated with Pulmonary Sarcoidosis

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16Gene Ontology
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Cellular components related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4CXCL9, CXCR3, CD27, CD69
2extracellular spaceGO:00561510.2IL9, CCL25, CCL15, CCL23, CCL3, SFTPD
3extracellular regionGO:00557610.0IFNA10, SFTPD, CCL3, CCL23, CCL25, IFNA17

Biological processes related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.6CXCL9, CCL25, CCL15, CCL23, CCL3, CXCR3
2T cell chemotaxisGO:01081810.6CXCR3, CCL3
3inflammatory responseGO:00695410.5CCL25, CCL23, CCL3, CXCR3, CXCR6, CXCL9
4immune responseGO:00695510.5CCL25, CCL15, CCL23, GZMA, CXCL5, CXCR6
5cell-cell signalingGO:00726710.5CCL15, CCL23, CCL3, GREM1, CXCL5, CXCL9
6cellular calcium ion homeostasisGO:00687410.5CCL15, CCL23, CCL3
7macrophage chemotaxisGO:04824610.4SFTPD, CCL3
8negative regulation of bone mineralizationGO:03050210.4GREM1, CCL3
9G-protein coupled receptor signaling pathwayGO:00718610.3CCL25, CCL23, CXCR6, CXCL9
10monocyte chemotaxisGO:00254810.1CCL3, CCL23

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.4CCL3, CCL15
2chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3, CCL23, CCL15, CCL25
3cytokine activityGO:00512510.4IFNA10, IFNA17, GREM1, CXCL9, IL9
4CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL23
5C-X-C chemokine receptor activityGO:01649410.2CXCR6, CXCR3

Products for genes affiliated with Pulmonary Sarcoidosis

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Sources for Pulmonary Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet