MCID: PLM018
MIFTS: 39

Pulmonary Sclerosing Hemangioma malady

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

Aliases & Descriptions for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 42 14 69
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 42 D047868
NCIt 47 C5656
SNOMED-CT 64 707365008
UMLS 69 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to hemangioma and sclerosing hemangioma, and has symptoms including chest pain, coughing and hemoptysis. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Coregulation of Androgen receptor activity and Arf6 trafficking events. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and lymph node, and related phenotypes are endocrine/exocrine gland and neoplasm

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 hemangioma 10.6
2 sclerosing hemangioma 10.6
3 kidney disease 10.2 NKX2-1 SYP
4 bone deterioration disease 10.2 NKX2-1 SYP
5 duodenal obstruction 10.2 NKX2-1 SYP
6 peroneal nerve paralysis 10.2 CHGA SYP
7 thymus small cell carcinoma 10.2 CHGA SYP
8 brain stem ependymoma 10.2 CHGA SYP
9 non specific chronic endometritis 10.2 CHGA SYP
10 extrahepatic biliary papillomatosis 10.2 CHGA SYP
11 prolactin producing pituitary tumor 10.2 CHGA SYP
12 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA SYP
13 gastrointestinal system benign neoplasm 10.2 CHGA NKX2-1
14 cartilage cancer 10.2 CHGA SYP
15 congenital muscular dystrophy with hyperlaxity 10.2 NKX2-1 SYP
16 jejunal neuroendocrine tumor 10.2 CHGA SYP
17 renal pelvis adenocarcinoma 10.2 CHGA SYP
18 barre-lieou syndrome 10.2 CHGA SYP
19 microinvasive cervical squamous cell carcinoma 10.2 CHGA SYP
20 perineural angioma 10.2 CHGA SYP
21 gastric duplication cysts 10.2 CHGA SYP
22 diffuse cutaneous mastocytosis 10.2 CHGA SYP
23 main bronchus cancer 10.2 CHGA SYP
24 gliofibroma 10.2 CHGA SYP
25 adult botryoid rhabdomyosarcoma 10.2 CHGA SYP
26 superior vena cava syndrome 10.2 CHGA SYP
27 agenesis and aplasia of uterine body 10.2 NKX2-1 SFTPB
28 fragile x-associated tremor/ataxia syndrome 10.2 CHGA SYP
29 hepatorenal syndrome 10.2 CHGA SYP
30 acalculous cholecystitis 10.2 CHGA SYP
31 piussan lenaerts mathieu syndrome 10.2 CHGA SYP
32 brain stem astrocytic neoplasm 10.2 CHGA SYP
33 anal squamous cell carcinoma 10.2 CHGA SYP
34 uterine corpus myxoid leiomyosarcoma 10.2 CHGA SYP
35 calcific tendinitis 10.2 CHGA SYP
36 pacinian tumor 10.2 NKX2-1 SYP
37 dysgerminoma of ovary 10.2 CHGA SYP
38 pediculus humanus corporis infestation 10.2 CHGA SYP
39 acinar cell cystadenocarcinoma 10.2 CHGA SYP
40 osteochondritis dissecans 10.2 NKX2-1 SFTPB
41 cowden syndrome 3 10.2 CHGA SYP
42 ampulla of vater mucinous adenocarcinoma 10.2 CHGA SYP
43 thymus squamous cell carcinoma 10.2 CHGA SYP
44 growth retardation hydrocephaly lung hypoplasia 10.2 CHGA SYP
45 testicular trophoblastic tumor 10.2 CHGA SYP
46 bone dysplasia azouz type 10.2 CHGA SYP
47 cardioauditory syndrome of sanchez cascos 10.2 CHGA SYP
48 proliferative glomerulonephritis 10.1 CTNNB1 SYP
49 eccrine papillary adenocarcinoma 10.1 CHGA SYP
50 vaginal villous adenoma 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


chest pain, coughing, hemoptysis

MGI Mouse Phenotypes related to Pulmonary Sclerosing Hemangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 AR CHGA CTNNB1 CTNND1 NKX2-1
2 neoplasm MP:0002006 8.92 AR CTNNB1 CTNND1 NKX2-1

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Lenograstim Approved Phase 3 135968-09-1
4
Doxil Approved June 1999 Phase 3 31703
5 Alkylating Agents Phase 3
6 Topoisomerase Inhibitors Phase 3
7 Anti-Bacterial Agents Phase 3
8 Isophosphamide mustard Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Antineoplastic Agents, Alkylating Phase 3
11
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
12
Indinavir Approved Phase 2 150378-17-9 5362440
13
protease inhibitors Phase 2
14 HIV Protease Inhibitors Phase 2
15 Cytochrome P-450 CYP3A Inhibitors Phase 2
16 Cytochrome P-450 Enzyme Inhibitors Phase 2
17 Anti-HIV Agents Phase 2
18 Anti-Infective Agents Phase 2
19 Liver Extracts Phase 2
20 Anti-Retroviral Agents Phase 2
21 Antiviral Agents Phase 2
22 Cola Nutraceutical Phase 2,Phase 1
23
Fluorouracil Approved Phase 1 51-21-8 3385
24
Belinostat Approved, Investigational Phase 1 866323-14-0
25 Interleukin-2 Phase 1
26 Analgesics Phase 1
27 Analgesics, Non-Narcotic Phase 1
28 Histone Deacetylase Inhibitors Phase 1
29 Androgens Phase 1
30 Vaccines Phase 1
31 Peripheral Nervous System Agents Phase 1
32 Immunosuppressive Agents Phase 1
33 Antimetabolites Phase 1
34 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3
2 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2
3 Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
4 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Recruiting NCT02601209 Phase 1, Phase 2
5 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1
6 Vaccine Therapy in Treating Patients With Metastatic Cancer Completed NCT00020267 Phase 1

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

39
Lung, Thyroid, Lymph Node, Bone, Kidney, Breast, Fetal Lung

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 60)
id Title Authors Year
1
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
2
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. ( 27812454 )
2016
3
Bone metastasis in pulmonary sclerosing hemangioma. ( 26552471 )
2015
4
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. ( 24944657 )
2014
5
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). ( 23290153 )
2013
6
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. ( 22291338 )
2013
7
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. ( 23838116 )
2013
8
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. ( 24887810 )
2013
9
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). ( 23587094 )
2013
10
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. ( 23910931 )
2013
11
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. ( 23227905 )
2012
12
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. ( 22740968 )
2012
13
Pulmonary sclerosing hemangioma: report of two cases. ( 22943472 )
2012
14
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. ( 22614067 )
2012
15
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. ( 21264765 )
2011
16
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. ( 21645337 )
2011
17
F-18 FDG PET/CT in evaluation of pulmonary sclerosing hemangioma. ( 21467848 )
2011
18
Pulmonary sclerosing hemangioma: pitfalls in management. ( 21471259 )
2011
19
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection. ( 22263122 )
2011
20
Coexistence of pulmonary sclerosing hemangioma and primary adenocarcinoma in the same nodule of lung. ( 21599956 )
2011
21
A case of pulmonary sclerosing hemangioma surrounded by giant cystic change on high-resolution computed tomography. ( 20634757 )
2011
22
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. ( 20422318 )
2011
23
Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. ( 21649526 )
2011
24
Large masses with diffuse calcification: pulmonary sclerosing hemangioma. ( 20732478 )
2010
25
Cytogenetic study of a pulmonary sclerosing hemangioma. ( 19837274 )
2009
26
Recurrence of pulmonary sclerosing hemangioma. ( 18278694 )
2008
27
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. ( 17383052 )
2007
28
Pulmonary sclerosing hemangioma manifesting as a nodule with irregular air clefts on high-resolution CT. ( 17579131 )
2007
29
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. ( 17914564 )
2007
30
Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma. ( 17873892 )
2007
31
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. ( 17473941 )
2007
32
Pulmonary sclerosing hemangioma with pulmonary metastasis. ( 16902885 )
2006
33
Pulmonary sclerosing hemangioma presenting as solitary pulmonary nodule: dynamic CT findings and histopathologic comparisons. ( 16861548 )
2006
34
Proteomic analysis of pulmonary sclerosing hemangioma. ( 16892484 )
2006
35
[Study of androgen receptor and phosphoglycerate kinase gene polymorphism in major cellular components of the so-called pulmonary sclerosing hemangioma]. ( 16776996 )
2006
36
Expression patterns of markers for type II pneumocytes in pulmonary sclerosing hemangiomas and fetal lung tissues. ( 15974816 )
2005
37
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. ( 16305908 )
2005
38
Expression of the estrogen receptor beta in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non-small cell lung carcinomas. ( 16226111 )
2005
39
Bilateral multiple pulmonary sclerosing hemangioma. ( 15828298 )
2005
40
Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. ( 15116333 )
2004
41
Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. ( 15188145 )
2004
42
Clinicopathological analysis of pulmonary sclerosing hemangioma. ( 15561002 )
2004
43
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. ( 15138814 )
2004
44
[Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]. ( 14720435 )
2003
45
Pulmonary sclerosing hemangioma with lymph node metastases. ( 14571291 )
2003
46
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. ( 12653576 )
2003
47
[The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. ( 11955335 )
2002
48
Cytopathologic diagnosis of pulmonary sclerosing hemangioma. ( 11892021 )
2002
49
Imprint cytologic features of pulmonary sclerosing hemangioma: comparison with well-differentiated papillary adenocarcinoma. ( 12115302 )
2002
50
A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. ( 10716159 )
2000

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 AR CTNNB1 NKX2-1
2 negative regulation of neuron death GO:1901215 9.46 CHGA CTNNB1
3 androgen receptor signaling pathway GO:0030521 9.43 AR CTNNB1
4 adherens junction organization GO:0034332 9.4 CTNNB1 CTNND1
5 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 CTNNB1 NKX2-1
6 cellular process GO:0009987 9.32 AR CTNNB1
7 entry of bacterium into host cell GO:0035635 9.26 CTNNB1 CTNND1
8 Leydig cell differentiation GO:0033327 9.16 AR NKX2-1
9 epithelial cell differentiation involved in prostate gland development GO:0060742 8.96 AR CTNNB1
10 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 8.62 AR CTNNB1

Molecular functions related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 AR CTNNB1 NKX2-1
2 RNA polymerase II transcription factor binding GO:0001085 8.96 AR CTNNB1
3 transcription regulatory region DNA binding GO:0044212 8.8 AR CTNNB1 NKX2-1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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