MCID: PLM018
MIFTS: 48

Pulmonary Sclerosing Hemangioma malady

Summaries for Pulmonary Sclerosing Hemangioma

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MalaCards: Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to sclerosing hemangioma and hemangioma. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Adherens junction and Glioma. The compounds cycloheximide and guanine have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and lymph node, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

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8Disease Ontology, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

pulmonary sclerosing hemangioma 8 60
pneumocytoma 8


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Disease Ontology8 DOID:5766
MeSH34 D047868
NCIt39 C5656

Related Diseases for Pulmonary Sclerosing Hemangioma

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1sclerosing hemangioma31.5SFTPB
2hemangioma31.5ACTC1, NKX2-1, SFTPB
3hemangioma of lung30.8SFTPB
4adenocarcinoma30.5AR, CTNNB1, CTNND1, FOXM1, SFTPB, TUBA1B
5familial adenomatous polyposis30.4CTNND1, CTNNB1, MYC, CDH1, AXIN1
6papillary adenocarcinoma30.2NKX2-1, MUC1
7non-small cell lung carcinoma30.2SFTPB, NKX2-1, SYP, CHGA, MYC, ENO2
8lung small cell carcinoma30.2NKX2-1, SYP, CHGA, MYC, MUC1, ENO2
9breast cancer30.2CTNND1, CTNNB1, AR, MYC, CDH1, ESR2
10colorectal cancer30.2CTNND1, CTNNB1, NKX2-1, MYC, CDH1, MMP9
11lung adenocarcinoma30.2SFTPB, FOXM1, CTNNB1, NKX2-1, MUC1, CDH1
12thyroiditis10.5
13spindle cell hemangioma10.2
14giant hemangioma10.2
15small cell carcinoma10.2
16breast hemangioma10.2
17mediastinitis10.2
18mesenchymoma10.0
19thymoma10.0NKX2-1
20angiomyolipoma10.0ACTC1
21pulmonary blastoma10.0NKX2-1
22lobular neoplasia10.0CTNND1
23papilloma10.0ACTC1
24gastritis10.0CHGA
25cerebral primitive neuroectodermal tumor10.0ENO2
26somatostatinoma10.0CHGA
27hepatitis b10.0FOXM1
28fasciitis10.0ACTC1
29chordoma10.0MUC1
30multiple endocrine neoplasia10.0CHGA
31cystadenocarcinoma10.0MUC1
32sertoli-leydig cell tumor10.0MUC1
33parathyroid adenoma10.0CHGA
34melanotic neuroectodermal tumor10.0SYP
35thyroid cancer10.0CHGA, NKX2-1
36huntington's disease10.0AR
37phaeochromocytoma10.0CHGA
38newborn respiratory distress syndrome10.0SFTPA1
39gynecomastia10.0AR
40glomus tumor10.0SYP, ACTC1
41gastrointestinal stromal tumor10.0ENO2, ACTC1
42alopecia10.0AR
43pulmonary fibrosis10.0MMP9
44meningioma10.0SYP, MUC1
45rhabdomyosarcoma10.0ENO2, ACTC1
46pulmonary alveolar proteinosis10.0SFTPB, MUC1
47leiomyoma10.0ESR2, ACTC1
48pancreatic islet cell tumors10.0SYP, CHGA
49hypertension10.0MMP9
50endometriosis10.0ESR2, ACTC1

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to pulmonary sclerosing hemangioma

Clinical Features for Pulmonary Sclerosing Hemangioma

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Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

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Genetic Tests for Pulmonary Sclerosing Hemangioma

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Anatomical Context for Pulmonary Sclerosing Hemangioma

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

32
Lung, Thyroid, Lymph node, Kidney, Breast, Fetal lung

Animal Models for Pulmonary Sclerosing Hemangioma or affiliated genes

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36MGI
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Publications for Pulmonary Sclerosing Hemangioma

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50PubMed
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Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. (23910931)
2013
2
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). (23290153)
2013
3
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). (23587094)
2013
4
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. (22291338)
2013
5
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. (23838116)
2013
6
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. (22740968)
2012
7
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. (23227905)
2012
8
Pulmonary sclerosing hemangioma: report of two cases. (22943472)
2012
9
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. (22614067)
2012
10
Pulmonary sclerosing hemangioma: pitfalls in management. (21471259)
2011
11
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. (21645337)
2011
12
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. (20422318)
2011
13
F-18 FDG PET/CT in evaluation of pulmonary sclerosing hemangioma. (21467848)
2011
14
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. (21264765)
2011
15
Multiple FDG-avid sclerosing hemangiomas mimicking pulmonary metastases in a case of soft tissue sarcoma. (20675249)
2010
16
Large masses with diffuse calcification: pulmonary sclerosing hemangioma. (20732478)
2010
17
Cytogenetic study of a pulmonary sclerosing hemangioma. (19837274)
2009
18
Recurrence of pulmonary sclerosing hemangioma. (18278694)
2008
19
Pulmonary sclerosing hemangioma manifesting as a nodule with irregular air clefts on high-resolution CT. (17579131)
2007
20
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. (17383052)
2007
21
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. (17473941)
2007
22
Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma. (17873892)
2007
23
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. (17914564)
2007
24
Study of androgen receptor and phosphoglycerate kinase gene polymorphism in major cellular components of the so-called pulmonary sclerosing hemangioma]. (16776996)
2006
25
Pulmonary sclerosing hemangioma with pulmonary metastasis. (16902885)
2006
26
Pulmonary sclerosing hemangioma presenting as solitary pulmonary nodule: dynamic CT findings and histopathologic comparisons. (16861548)
2006
27
Proteomic analysis of pulmonary sclerosing hemangioma. (16892484)
2006
28
Bilateral multiple pulmonary sclerosing hemangioma. (15828298)
2005
29
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. (16305908)
2005
30
Expression patterns of markers for type II pneumocytes in pulmonary sclerosing hemangiomas and fetal lung tissues. (15974816)
2005
31
Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. (15116333)
2004
32
Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. (15188145)
2004
33
Clinicopathological analysis of pulmonary sclerosing hemangioma. (15561002)
2004
34
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. (12653576)
2003
35
Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]. (14720435)
2003
36
Pulmonary sclerosing hemangioma with lymph node metastases. (14571291)
2003
37
The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. (11955335)
2002
38
Cytopathologic diagnosis of pulmonary sclerosing hemangioma. (11892021)
2002
39
A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. (10716159)
2000
40
Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): a new clue to its histogenesis. (11075855)
2000
41
A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. (10895813)
2000
42
Pulmonary sclerosing hemangioma: report of a case with emphasis on dynamic MR imaging findings. (9192438)
1997
43
Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney. (8702253)
1996
44
Positive expression of c-myc and p53 products in two cases of pulmonary sclerosing hemangioma]. (8821986)
1995
45
Fine needle aspiration cytodiagnosis of pulmonary sclerosing hemangioma. (7762366)
1995
46
Pulmonary sclerosing hemangioma: unusual cause of a solitary pulmonary nodule. (2257512)
1990
47
Pulmonary sclerosing hemangioma of the lung. A type II pneumocytoma by immunohistochemical and immunoelectron microscopic studies. (2548701)
1989
48
The intravascular bronchioloalveolar tumor and the sclerosing hemangioma of the lung: misnomers of pulmonary neoplasia. (3039630)
1985
49
Pulmonary sclerosing hemangioma: sometimes a form of pulmonary hamartoma. (7089615)
1982
50
Non-neoplastic sclerotic pulmonary lesion (sclerosing hemangioma). Report of a case. (4331028)
1971

Genetic Variations for Pulmonary Sclerosing Hemangioma

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Expression for genes affiliated with Pulmonary Sclerosing Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for genes affiliated with Pulmonary Sclerosing Hemangioma

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 52R&D Systems, 55SinoBiological, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Pulmonary Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CTNND1
2
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9.8AR, MYC
39.8CDH1, CTNND1
49.6CDH1, CTNNB1
59.6CTNNB1, CDH1
69.6CTNND1, CTNNB1, AXIN1
79.6AR, MYC, AXIN1
89.5AXIN1, MYC, CTNNB1
99.5AXIN1, MYC, CTNNB1
109.5ESR2, MYC, AR
119.4CTNND1, CTNNB1, CDH1
129.4CTNND1, CTNNB1, CDH1
139.4CTNND1, CDH1, MMP9
149.4CTNNB1, MUC1, CDH1
159.3CTNNB1, MYC, CDH1
16
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9.3CTNND1, CTNNB1, MYC, AXIN1
17
Hide members
9.2CDH1, CTNNB1, CTNND1, SFTPA1
189.2ACTC1, CDH1, CTNNB1, CTNND1
19
Cell adhesion Gap junctions
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9.2ACTC1, TUBA1A, TUBA1B
209.1ESR2, MYC, AR, CTNNB1
219.1CDH1, MUC1, CTNNB1, CTNND1
22
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9.1AXIN1, CDH1, MYC, CTNNB1
23
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9.1AXIN1, CDH1, MYC, CTNNB1
249.1AXIN1, CDH1, MYC, CTNNB1
259.1CTNNB1, MYC, CDH1, AXIN1
269.1CTNNB1, MYC, CDH1, AXIN1
279.0CTNNB1, AR, MYC, CDH1
289.0FOXM1, CTNNB1, AR, ESR2
29
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8.9ESR2, AXIN1, CDH1, MYC, CTNND1
30
Cytoskeleton remodeling Reverse signaling by ephrin B
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8.8TUBA1B, TUBA1A, CTNNB1, AXIN1
318.6TUBA1B, NKX2-1, SYP, ENO2
32
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8.6CTNNB1, MYC, MUC1, CDH1, MMP9
338.6MMP9, CDH1, MYC, AR, CTNNB1
348.5ACTC1, CDH1, CTNND1, TUBA1A, TUBA1B
35
Development Slit-Robo signaling
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8.3TUBA1B, TUBA1A, CTNNB1, CDH1, ACTC1
368.3MMP9, AXIN1, CDH1, MYC, AR, CTNNB1

Compounds for genes affiliated with Pulmonary Sclerosing Hemangioma

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Pulmonary Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6SFTPB
2guanine44 11 2412.5AR
3dihydrotestosterone44 28 11 2413.4ESR2
4mucicarmine4410.0NKX2-1, SYP, MUC1, ACTC1
5butyrate4410.0TUBA1B
6glutamate449.7TUBA1B, AR
7smcc449.7ENO2, CHGA, SYP
82,4-dinitrophenol449.7SFTPB, AR, NKX2-1
9bicalutamide44 59 1111.5CTNNB1, AR, CHGA, ESR2
10cyclopamine44 5910.5CTNNB1, MYC, CDH1
11s 100449.3SYP, CHGA, MUC1, ACTC1, ENO2
12b 723449.3NKX2-1, SYP, CHGA, MUC1, CDH1, ACTC1
13creatinine449.2SYP, CHGA, CDH1, MMP9, ACTC1
14estramustine44 1110.1TUBA1B, AR, CHGA, ESR2
15vitamin a44 11 2411.1SFTPB, CTNNB1, MYC, MMP9
16forskolin44 49 1110.9TUBA1B, NKX2-1, ENO2
17retinoid448.8SFTPB, CTNNB1, AR, MYC, CDH1, ESR2
185-aza-2deoxycytidine448.8ESR2, CDH1, MYC, AR, CTNNB1
19actinomycin d448.8SFTPB, AR, MYC, MUC1, MMP9, ESR2
20curcumin448.7CTNNB1, AR, MYC, CDH1, MMP9
21etoposide44 49 59 1111.7TUBA1B, AR, CHGA, CDH1, ESR2
22sucrose44 11 2410.7CTNNB1, SYP, CHGA, CDH1, SFTPB
23dmso448.7ESR2, ENO2, MUC1, MYC, CHGA
24hyaluronic acid44 249.6MYC, MUC1, CDH1, MMP9, ENO2
25steroid448.6TUBA1B, FOXM1, AR, NKX2-1, SYP, ACTC1
26matrigel448.6CTNNB1, AR, CHGA, MUC1, CDH1, MMP9
27agar448.5FOXM1, CTNNB1, AR, MYC, MUC1, CDH1
28tamoxifen44 49 28 1111.5CTNNB1, AR, CHGA, MYC, MUC1, CDH1
29paclitaxel44 49 1110.5TUBA1B, CTNNB1, CHGA, MYC, CDH1
30silver448.5TUBA1B, SYP, CHGA, CDH1, ENO2
31genistein44 28 59 2 11 2413.4CTNNB1, AR, SYP, MYC, CDH1, MMP9
3212-o-tetradecanoylphorbol 13-acetate448.4SFTPB, FOXM1, CHGA, MYC, MUC1, CDH1
33hematoxylin448.3NKX2-1, SYP, CHGA, MUC1, CDH1, MMP9
34formaldehyde44 249.3NKX2-1, SYP, CHGA, MUC1, CDH1, MMP9
35chloramphenicol44 2 1110.2SFTPB, FOXM1, AR, CHGA, MYC, MUC1
36ribonucleic acid448.1SFTPB, NKX2-1, CHGA, MYC, MUC1, MMP9
37serine448.1TUBA1B, SFTPB, CTNND1, NKX2-1, SYP, CDH1
38doxorubicin44 49 1110.1TUBA1B, CTNNB1, AR, MYC, CDH1, ESR2
39docetaxel44 49 59 1111.1TUBA1B, TUBA1A, AR, MYC, CDH1, ENO2
40cysteine447.5TUBA1B, SFTPB, CTNNB1, SYP, CHGA, MUC1
41cisplatin44 49 59 1110.5TUBA1B, CTNNB1, SYP, CHGA, MYC, MUC1
42progesterone44 59 28 11 2411.5SFTPB, CTNNB1, AR, NKX2-1, SYP, CHGA
43testosterone44 59 11 2410.4CTNNB1, AR, SYP, CHGA, MUC1, CDH1
44glycogen44 248.3TUBA1B, CTNNB1, SYP, CHGA, MYC, MUC1
45dexamethasone44 49 28 1110.2SFTPB, CTNNB1, AR, NKX2-1, MYC, CDH1
46calcium44 49 11 249.8TUBA1B, SFTPA1, SFTPB, CTNND1, SYP, CHGA
47paraffin446.7SFTPB, ESR2, ENO2, CTNNB1, AR, NKX2-1
48tyrosine446.3TUBA1B, SFTPB, CTNND1, CTNNB1, NKX2-1, SYP
49vegf445.8TUBA1B, SFTPB, CTNND1, CTNNB1, AR, SYP
50retinoic acid44 246.4AR, NKX2-1, SYP, CHGA, MYC, MUC1

GO Terms for genes affiliated with Pulmonary Sclerosing Hemangioma

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16Gene Ontology
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Cellular components related to Pulmonary Sclerosing Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:0308779.9AXIN1, CTNNB1
2cell-cell adherens junctionGO:0059139.5CDH1, CTNNB1, CTNND1
3lateral plasma membraneGO:0163289.4AXIN1, CDH1, CTNNB1
4catenin complexGO:0163429.3CDH1, CTNNB1
5cytoplasmic microtubuleGO:0058819.1TUBA1B, TUBA1A, AXIN1

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiation involved in prostate gland developmentGO:06074210.0AR, CTNNB1
2prostate gland epithelium morphogenesisGO:06074010.0ESR2, AR
3dorsal/ventral axis specificationGO:0099509.9AXIN1, CTNNB1
4epithelial tube branching involved in lung morphogenesisGO:0604419.9NKX2-1, CTNNB1
5regulation of protein localization to cell surfaceGO:20000089.9CTNNB1, CDH1
6cellular response to indole-3-methanolGO:0716819.9CTNNB1, CDH1
7negative regulation of stress-activated MAPK cascadeGO:0328739.8MYC, FOXM1
8canonical Wnt receptor signaling pathwayGO:0600709.6CTNNB1, MYC, AXIN1
9cytoskeleton-dependent intracellular transportGO:0307059.6TUBA1A, TUBA1B
10cell-cell adhesionGO:0163379.3CTNND1, CTNNB1, CDH1
11response to drugGO:0424938.8ACTC1, CDH1, MYC, CTNNB1
12negative regulation of transcription from RNA polymerase II promoterGO:0001228.8ESR2, MYC, NKX2-1, CTNNB1, FOXM1
13positive regulation of transcription, DNA-dependentGO:0458938.3AXIN1, FOXM1, CTNNB1, AR, NKX2-1, MYC

Molecular functions related to Pulmonary Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1beta-catenin bindingGO:0080139.6AR, CDH1, AXIN1
2I-SMAD bindingGO:0704119.6AXIN1, CTNNB1
3protein phosphatase bindingGO:0199039.6CDH1, CTNNB1, CTNND1
4enzyme bindingGO:0198999.3ESR2, AXIN1, AR, CTNNB1
5transcription regulatory region DNA bindingGO:0442129.3FOXM1, CTNNB1, AR, NKX2-1
6structural constituent of cytoskeletonGO:0052009.2SYNM, TUBA1A, TUBA1B
7transcription factor bindingGO:0081348.8FOXM1, CTNNB1, AR, MYC
8sequence-specific DNA binding transcription factor activityGO:0037008.4FOXM1, CTNNB1, AR, NKX2-1, MYC, ESR2
9protein bindingGO:0055155.7ESR2, TUBA1B, TUBA1A, FOXM1, CTNND1, CTNNB1

Products for genes affiliated with Pulmonary Sclerosing Hemangioma

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Sources for Pulmonary Sclerosing Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet