MCID: PLM018
MIFTS: 38

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 42 14 69
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 42 D047868
NCIt 47 C5656
SNOMED-CT 64 707365008
UMLS 69 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to hemangioma and sclerosing hemangioma, and has symptoms including chest pain, coughing and hemoptysis. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Adherens junction and Coregulation of Androgen receptor activity. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and brain, and related phenotypes are endocrine/exocrine gland and neoplasm

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 hemangioma 10.6
2 sclerosing hemangioma 10.6
3 skin papilloma 10.6 NKX2-1 SYP
4 pleural empyema 10.5 NKX2-1 SYP
5 mature teratoma 10.5 NKX2-1 SYP
6 spondyloepimetaphyseal dysplasia, isidor type 10.5 NKX2-1 SYP
7 superior mesenteric artery syndrome 10.5 NKX2-1 SYP
8 malignant ovarian mixed epithelial neoplasm 10.5 CHGA SYP
9 ampulla of vater small cell carcinoma 10.5 CHGA SYP
10 spinal cord ependymoma 10.5 CHGA SYP
11 bladder benign neoplasm 10.5 CHGA NKX2-1
12 ludwig's angina 10.5 CHGA SYP
13 signet ring cell intrahepatic cholangiocarcinoma 10.5 CHGA SYP
14 childhood choriocarcinoma of the ovary 10.5 CHGA SYP
15 osteoblastoma 10.5 CHGA SYP
16 basophilic carcinoma 10.5 CHGA SYP
17 cystitis cystica 10.5 CHGA SYP
18 neurogenic thoracic outlet syndrome 10.5 CHGA SYP
19 aicardi-goutieres syndrome 10.5 CHGA SYP
20 diffuse infiltrative lymphocytosis syndrome 10.5 CHGA SYP
21 congenital granular cell tumor 10.5 CHGA SYP
22 reticular pattern testicular yolk sac tumor 10.5 CHGA SYP
23 mast cell neoplasm 10.5 CHGA SYP
24 bone development disease 10.5 NKX2-1 SYP
25 diffuse lipomatosis 10.5 CHGA SYP
26 pleomorphic xanthoastrocytoma 10.5 CHGA SYP
27 pacinian tumor 10.5 NKX2-1 SYP
28 thyroid sarcoma 10.5 CHGA SYP
29 sudden sensorineural hearing loss 10.4 CHGA SYP
30 pituitary dwarfism with large sella turcica 10.4 CHGA SYP
31 pneumonia 10.4 CHGA SYP
32 ethmoid sinus schneiderian papilloma 10.4 CHGA SYP
33 rete ovarii cystadenofibroma 10.4 CHGA SYP
34 pancreatic agenesis 10.4 CHGA SYP
35 nose disease 10.4 CHGA SYP
36 perianal skin paget's disease 10.4 CHGA SYP
37 hepatorenal syndrome 10.4 CHGA SYP
38 tricuspid valve insufficiency 10.4 CHGA SYP
39 brain stem ependymoma 10.4 CHGA SYP
40 pediatric ependymoma 10.4 CHGA SYP
41 gliofibroma 10.4 CHGA SYP
42 group b strep disease in newborns 10.4 CHGA SYP
43 calcific tendinitis 10.4 CHGA SYP
44 osteoarthritis 10.4 NKX2-1 SFTPB
45 bladder cancer, childhood 10.4 CHGA SYP
46 carcinoma of unknown primary site, childhood 10.4 CHGA SYP
47 internal auditory canal lipoma 10.4 CHGA SYP
48 anal canal adenocarcinoma 10.4 CHGA SYP
49 middle ear squamous cell carcinoma 10.4 CHGA SYP
50 periosteal osteogenic sarcoma 10.4 CTNNB1 NKX2-1

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


chest pain, coughing, hemoptysis

MGI Mouse Phenotypes related to Pulmonary Sclerosing Hemangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 NKX2-1 AR CHGA CTNNB1 CTNND1
2 neoplasm MP:0002006 8.92 AR CTNNB1 CTNND1 NKX2-1

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Lenograstim Approved Phase 3 135968-09-1
4
Doxil Approved June 1999 Phase 3 31703
5 Alkylating Agents Phase 3
6 Anti-Bacterial Agents Phase 3
7 Antibiotics, Antitubercular Phase 3
8 Isophosphamide mustard Phase 3
9 Topoisomerase Inhibitors Phase 3
10
Indinavir Approved Phase 2 150378-17-9 5362440
11
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
12 Anti-HIV Agents Phase 2
13 Anti-Infective Agents Phase 2
14 Anti-Retroviral Agents Phase 2
15 Antiviral Agents Phase 2
16 Cytochrome P-450 CYP3A Inhibitors Phase 2
17 Cytochrome P-450 Enzyme Inhibitors Phase 2
18 HIV Protease Inhibitors Phase 2
19 Liver Extracts Phase 2
20
protease inhibitors Phase 2
21 Cola Nutraceutical Phase 2,Phase 1
22
Belinostat Approved, Investigational Phase 1 866323-14-0
23
Fluorouracil Approved Phase 1 51-21-8 3385
24 Androgens Phase 1
25 Antimetabolites Phase 1
26 Antimetabolites, Antineoplastic Phase 1
27 Histone Deacetylase Inhibitors Phase 1
28 Immunosuppressive Agents Phase 1
29 Analgesics Phase 1
30 Analgesics, Non-Narcotic Phase 1
31 Interleukin-2 Phase 1
32 Peripheral Nervous System Agents Phase 1
33 Vaccines Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
2 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
3 Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
4 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
5 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
6 Vaccine Therapy in Treating Patients With Metastatic Cancer Completed NCT00020267 Phase 1 interleukin-2;MAGE-12 peptide vaccine;Montanide ISA-51

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

39
Lung, Bone, Brain, Liver, Thyroid, Lymph Node, Fetal Lung

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 61)
id Title Authors Year
1
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. ( 28357098 )
2017
2
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. ( 27812454 )
2016
3
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
4
Bone metastasis in pulmonary sclerosing hemangioma. ( 26552471 )
2015
5
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. ( 24944657 )
2014
6
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. ( 23910931 )
2013
7
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). ( 23587094 )
2013
8
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). ( 23290153 )
2013
9
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. ( 23838116 )
2013
10
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. ( 24887810 )
2013
11
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. ( 22291338 )
2013
12
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. ( 22740968 )
2012
13
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. ( 22614067 )
2012
14
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. ( 23227905 )
2012
15
Pulmonary sclerosing hemangioma: report of two cases. ( 22943472 )
2012
16
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. ( 21264765 )
2011
17
Pulmonary sclerosing hemangioma: pitfalls in management. ( 21471259 )
2011
18
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. ( 21645337 )
2011
19
A case of pulmonary sclerosing hemangioma surrounded by giant cystic change on high-resolution computed tomography. ( 20634757 )
2011
20
F-18 FDG PET/CT in evaluation of pulmonary sclerosing hemangioma. ( 21467848 )
2011
21
Coexistence of pulmonary sclerosing hemangioma and primary adenocarcinoma in the same nodule of lung. ( 21599956 )
2011
22
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. ( 20422318 )
2011
23
Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. ( 21649526 )
2011
24
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection. ( 22263122 )
2011
25
Large masses with diffuse calcification: pulmonary sclerosing hemangioma. ( 20732478 )
2010
26
Cytogenetic study of a pulmonary sclerosing hemangioma. ( 19837274 )
2009
27
Recurrence of pulmonary sclerosing hemangioma. ( 18278694 )
2008
28
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. ( 17914564 )
2007
29
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. ( 17383052 )
2007
30
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. ( 17473941 )
2007
31
Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma. ( 17873892 )
2007
32
Pulmonary sclerosing hemangioma manifesting as a nodule with irregular air clefts on high-resolution CT. ( 17579131 )
2007
33
Pulmonary sclerosing hemangioma with pulmonary metastasis. ( 16902885 )
2006
34
Proteomic analysis of pulmonary sclerosing hemangioma. ( 16892484 )
2006
35
Pulmonary sclerosing hemangioma presenting as solitary pulmonary nodule: dynamic CT findings and histopathologic comparisons. ( 16861548 )
2006
36
[Study of androgen receptor and phosphoglycerate kinase gene polymorphism in major cellular components of the so-called pulmonary sclerosing hemangioma]. ( 16776996 )
2006
37
Expression of the estrogen receptor beta in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non-small cell lung carcinomas. ( 16226111 )
2005
38
Expression patterns of markers for type II pneumocytes in pulmonary sclerosing hemangiomas and fetal lung tissues. ( 15974816 )
2005
39
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. ( 16305908 )
2005
40
Bilateral multiple pulmonary sclerosing hemangioma. ( 15828298 )
2005
41
Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. ( 15116333 )
2004
42
Clinicopathological analysis of pulmonary sclerosing hemangioma. ( 15561002 )
2004
43
Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. ( 15188145 )
2004
44
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. ( 15138814 )
2004
45
Pulmonary sclerosing hemangioma with lymph node metastases. ( 14571291 )
2003
46
[Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]. ( 14720435 )
2003
47
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. ( 12653576 )
2003
48
Imprint cytologic features of pulmonary sclerosing hemangioma: comparison with well-differentiated papillary adenocarcinoma. ( 12115302 )
2002
49
Cytopathologic diagnosis of pulmonary sclerosing hemangioma. ( 11892021 )
2002
50
[The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. ( 11955335 )
2002

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 AR CTNNB1 NKX2-1
2 forebrain development GO:0030900 9.49 CTNNB1 NKX2-1
3 negative regulation of neuron death GO:1901215 9.46 CHGA CTNNB1
4 androgen receptor signaling pathway GO:0030521 9.43 AR CTNNB1
5 adherens junction organization GO:0034332 9.4 CTNNB1 CTNND1
6 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 CTNNB1 NKX2-1
7 cellular process GO:0009987 9.32 AR CTNNB1
8 entry of bacterium into host cell GO:0035635 9.26 CTNNB1 CTNND1
9 Leydig cell differentiation GO:0033327 9.16 AR NKX2-1
10 epithelial cell differentiation involved in prostate gland development GO:0060742 8.96 AR CTNNB1
11 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 8.62 AR CTNNB1

Molecular functions related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 AR CTNNB1 NKX2-1
2 RNA polymerase II transcription factor binding GO:0001085 8.96 AR CTNNB1
3 transcription regulatory region DNA binding GO:0044212 8.8 AR CTNNB1 NKX2-1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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