MCID: PLM064
MIFTS: 26

Pulmonary Sequestration

Categories: Rare diseases, Respiratory diseases, Fetal diseases

Aliases & Classifications for Pulmonary Sequestration

MalaCards integrated aliases for Pulmonary Sequestration:

Name: Pulmonary Sequestration 50

Classifications:



Summaries for Pulmonary Sequestration

NIH Rare Diseases : 50 pulmonary sequestration is a rare congenital (present from birth) malformation where non-functioning lung tissue is separated from the rest of the lung and supplied with blood from an unusual source, often an artery from systemic circulation. pulmonary sequestrations may be defined as intralobular or extralobular, depending on their location. symptoms may include a chronic  or recurrent cough, respiratory distress or lung infection. treatment depends on the location and may involve surgery. last updated: 8/12/2016

MalaCards based summary : Pulmonary Sequestration is related to congenital pulmonary sequestration and intralobar congenital pulmonary sequestration. An important gene associated with Pulmonary Sequestration is DICER1 (Dicer 1, Ribonuclease III). The drugs Protein C and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and neutrophil.

Wikipedia : 72 A pulmonary sequestration (bronchopulmonary sequestration or cystic lung lesion), is a medical condition... more...

Related Diseases for Pulmonary Sequestration

Diseases in the Pulmonary Sequestration family:

Congenital Pulmonary Sequestration

Diseases related to Pulmonary Sequestration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 congenital pulmonary sequestration 12.1
2 intralobar congenital pulmonary sequestration 11.9
3 extralobar congenital pulmonary sequestration 11.9
4 aneurysm 10.1
5 bronchogenic cyst 10.0
6 congenital diaphragmatic hernia 9.9
7 mediastinitis 9.9
8 hydrops fetalis 9.9
9 lung cancer 9.9
10 aspergillosis 9.9
11 diaphragmatic eventration 9.9
12 esophagitis 9.9
13 tuberculosis 9.9
14 adenocarcinoma 9.8
15 neuroblastoma 9.7
16 congestive heart failure 9.7
17 patent ductus arteriosus 9.7
18 ventricular septal defect 9.7
19 aortic aneurysm 9.7
20 pancreatitis 9.7
21 pneumonia 9.7
22 vasculitis 9.7
23 cardiomyopathy 9.7
24 pheochromocytoma 9.6
25 asthma 9.6
26 breast cancer 9.6
27 tetralogy of fallot 9.6
28 aicardi syndrome 9.6
29 laryngomalacia 9.6
30 duodenal atresia 9.6
31 pulmonary atresia with intact ventricular septum 9.6
32 pulmonary atresia with ventricular septal defect 9.6
33 atherosclerosis 9.6
34 cerebral palsy 9.6
35 chronic granulomatous disease 9.6
36 dilated cardiomyopathy 9.6
37 leukemia 9.6
38 primary ciliary dyskinesia 9.6
39 fibroma 9.6
40 lymphoma 9.6
41 sarcoma 9.6
42 arteriovenous malformation 9.6
43 mitral valve insufficiency 9.6
44 blastomycosis 9.6
45 vacterl association 9.6
46 cystic nephroma 9.6
47 lung sarcoma 9.6
48 ischemia 9.6
49 thymoma 9.6
50 cerebritis 9.6

Graphical network of the top 20 diseases related to Pulmonary Sequestration:



Diseases related to Pulmonary Sequestration

Symptoms & Phenotypes for Pulmonary Sequestration

Drugs & Therapeutics for Pulmonary Sequestration

Drugs for Pulmonary Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Protein C Approved Phase 2
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
4 Alpha 1-Antitrypsin Phase 2
5 HIV Protease Inhibitors Phase 2
6
protease inhibitors Phase 2
7 Protein C Inhibitor Phase 2
8 Serine Proteinase Inhibitors Phase 2
9 Trypsin Inhibitors Phase 2
10 Albumin-Bound Paclitaxel Phase 2
11 Anti-Infective Agents Phase 2
12 Antimetabolites Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Antimitotic Agents Phase 2
15 Antineoplastic Agents, Phytogenic Phase 2
16 Antiviral Agents Phase 2
17 Immunosuppressive Agents Phase 2
18 serine Nutraceutical Phase 2
19
Iron Approved 7439-89-6 23925
20 Micronutrients
21 Trace Elements
22 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients Unknown status NCT01394835 Phase 2 Alpha -1 Antitrypsin;Alpha-1 Antitrypsin;AAT
2 Nab-pacliatxel Plus Gemcitabine in Korean Patients With Metastatic Pancreatic Ductal Adenocarcinoma Recruiting NCT02426281 Phase 2 nab-paclitaxel;gemcitabine
3 Cardiopulmonary Circuits in the Pediatric Population Completed NCT00208728
4 Iron Absorption and Utilization During Tuberculosis and After Treatment Completed NCT02176772
5 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769
6 Goal-directed Fluid Resuscitation in Acute Pancreatitis Terminated NCT00853515

Search NIH Clinical Center for Pulmonary Sequestration

Genetic Tests for Pulmonary Sequestration

Anatomical Context for Pulmonary Sequestration

MalaCards organs/tissues related to Pulmonary Sequestration:

39
Lung, Heart, Neutrophil, Bone Marrow, Liver, Bone, Myeloid

Publications for Pulmonary Sequestration

Articles related to Pulmonary Sequestration:

(show top 50) (show all 603)
id Title Authors Year
1
Anomalous systemic arterial supply of pulmonary sequestration in adult patients. ( 28197222 )
2017
2
Transcatheter embolization of a large aberrant systemic artery to an intralobar pulmonary sequestration using an Amplatzer vascular plug in an adolescent. ( 28275570 )
2017
3
Image Diagnosis: Carcinoid Tumorlets and Pulmonary Sequestration in a Patient With Chronic Cough Without a History of Malignancy. ( 28678694 )
2017
4
Extension of a Stanford type A aortic dissection into the feeding vessel of a pulmonary sequestration. ( 28329296 )
2017
5
Percutaneous laser ablation of the feeding vessel in pulmonary sequestration or hybrid lesions. ( 28573774 )
2017
6
Atypical pulmonary sequestration causing respiratory distress in a 2-month-old male infant. ( 28243740 )
2017
7
Transarterial embolization of intralobar pulmonary sequestration in a young adult with hemoptysis. ( 28449501 )
2017
8
Anatomical Segmentectomy with a Hybrid VATS Approach in a Patient with Intralobar Pulmonary Sequestration after Severe Pneumonia: A Case Report. ( 28680790 )
2017
9
Pulmonary sequestration mimicking a pancreas herniation in a case of recurrent Bochdalek hernia. ( 28203431 )
2017
10
Bronchopulmonary foregut malformation presenting as extralobar pulmonary sequestration associated with a bronchogenic cyst: an unusual clinical and radiological feature in an adolescent patient. ( 28840031 )
2017
11
Atherosclerosis of aberrant arteries from the left gastric artery into the right intralobar pulmonary sequestration complicated by mycobacterial epithelioid cell granuloma. ( 27776258 )
2017
12
Intralobar pulmonary sequestration displayed as localized emphysema on computed tomography image. ( 28886716 )
2017
13
Extralobar pulmonary sequestration in two pinniped species. ( 28924092 )
2017
14
Concurrent pulmonary sequestration and pulmonary hydatid cyst in a child: A case report. ( 28440965 )
2017
15
Complete resolution of hydrops by placement of double basket catheter in a case of macrocystic type multilocular pulmonary sequestration. ( 28600060 )
2017
16
Clinical benefits, echocardiographic and MRI assessment after pulmonary sequestration treatment. ( 28495248 )
2017
17
Clinical presentation and characteristics of 25 adult cases of pulmonary sequestration. ( 28449484 )
2017
18
Mass Effect of Pulmonary Sequestration: Multiloculated-Multiseptated Pneumomediastinum. ( 27123402 )
2016
19
Pulmonary Sequestration: An Unusual Cause of Elevated CA 19-9. ( 27151113 )
2016
20
Robot-assisted segmental resection for intralobar pulmonary sequestration. ( 27061483 )
2016
21
Anomalous systemic arterial supply to the left lower lobe without evidence of pulmonary sequestration. ( 26923779 )
2016
22
Hemoptysis caused by pulmonary sequestration in perforated appendicitis: A rare case report. ( 28074452 )
2016
23
Undiagnosed pulmonary sequestration results in an unexplained hemorrhagic shock in thoracoscopic pulmonary lobectomy. ( 27871579 )
2016
24
An Aneurysmal Abdominal Aortic Branch Supplying an Intralobar Pulmonary Sequestration. ( 27000616 )
2016
25
Extralobar pulmonary sequestration as a cause of recurrent pulmonary hemorrhage in a neonate. ( 26914085 )
2016
26
Unusual Form of Pulmonary Sequestration: Emphysematous Sequestration. ( 27645986 )
2016
27
Isolated metastasis of testicular seminoma to extralobar pulmonary sequestration. ( 26744493 )
2016
28
Bilateral Intralobar Pulmonary Sequestration in a Young Adult. A Case Report. ( 27818027 )
2016
29
Coil occlusion of aberrant arteries to pulmonary sequestration in a case with pulmonary atresia with intact ventricular septum: successful treatment of repetitive myocardial ischaemic attacks. ( 27702416 )
2016
30
Congenital diaphragmatic hernia with recurrent gastric volvulus and pulmonary sequestration: A "chance" combination. ( 26862295 )
2016
31
Endovascular embolization prior to surgical resection of symptomatic intralobar pulmonary sequestration in an adult. ( 27069973 )
2016
32
EP10.19: Subdiaphragmatic extralobar pulmonary sequestration: report of two cases. ( 27644474 )
2016
33
Bronchial and Systemic Artery Embolization of Hemorrhagic Adenocarcinoma Arising from a Pulmonary Sequestration. ( 26723930 )
2016
34
Extralobar Pulmonary Sequestration with Accompanying Ipsilateral Diaphragmatic Eventration. ( 27670535 )
2016
35
Type II congenital pulmonary airway malformation associated with intralobar pulmonary sequestration: report of a case and review of classification criteria. ( 28195247 )
2016
36
Heart Failure in a Preterm Infant. Case Report and Echocardiographic Clues for the Diagnostic Approach to Pulmonary Sequestration. ( 27250095 )
2016
37
Pulmonary sequestration associated with significant elevation of serum carbohydrate antigen 19-9: report of two cases. ( 27826576 )
2016
38
Extralobar pulmonary sequestration in the middle mediastinum. ( 27915420 )
2016
39
Short-term outcome of percutaneous treatment of pulmonary sequestration in a pediatric hospital in the Andes: A case series. ( 27470707 )
2016
40
Necrotizing arteritis occurring in an intralobar pulmonary sequestration of a patient without systemic vasculitis syndrome. ( 26874730 )
2016
41
Isolated subdiaphragmatic extralobar pulmonary sequestration: masquerading as suprarenal mass with spontaneous resolution. ( 27328516 )
2016
42
Use of Amplatzer Vascular Plugs for the treatment of combined extralobar and intralobar pulmonary sequestration in a 5-year-old child. ( 27322920 )
2016
43
Intralobar Pulmonary Sequestration With Aneurysmal Feeding Vessel: Use of Hybrid Surgical Management. ( 27847074 )
2016
44
Extralobar Aneurysm of Intralobar Pulmonary Sequestration Artery Originating From Aorta Arch. ( 27000615 )
2016
45
Uniportal thoracoscopic lobectomy for intralobar pulmonary sequestration. ( 26868145 )
2016
46
Rare presentation of intralobar pulmonary sequestration associated with repeated episodes of ventricular tachycardia. ( 27468336 )
2016
47
Intralobar pulmonary sequestration in elderly woman: a rare case report with emphasis on imaging findings. ( 27594937 )
2016
48
Extralobar pulmonary sequestration in neonates: The natural course and predictive factors associated with spontaneous regression. ( 27659701 )
2016
49
Bilateral Intralobar Pulmonary Sequestration With a Bridging Isthmus in a Young Adult. ( 27549558 )
2016
50
Evaluation of pulmonary sequestration with multidetector computed tomography angiography in a select cohort of patients: A retrospective study. ( 27464296 )
2016

Variations for Pulmonary Sequestration

Expression for Pulmonary Sequestration

Search GEO for disease gene expression data for Pulmonary Sequestration.

Pathways for Pulmonary Sequestration

GO Terms for Pulmonary Sequestration

Sources for Pulmonary Sequestration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....