MCID: PLM071
MIFTS: 25

Pulmonary Surfactant Metabolism Dysfunction malady

Respiratory, Metabolic categories

Summaries for Pulmonary Surfactant Metabolism Dysfunction

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MalaCards: Pulmonary Surfactant Metabolism Dysfunction, also known as pulmonary alveolar proteinosis, is related to pulmonary alveolar proteinosis and idiopathic pulmonary fibrosis. An important gene associated with Pulmonary Surfactant Metabolism Dysfunction is SFTPC (surfactant protein C). The compounds infasurf and dppg have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotype respiratory system.

Aliases & Classifications for Pulmonary Surfactant Metabolism Dysfunction

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61UMLS, 20GeneTests, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Metabolic


Aliases & Descriptions:

pulmonary surfactant metabolism dysfunction 20 22
pulmonary alveolar proteinosis 61
lung diseases, interstitial 61


Related Diseases for Pulmonary Surfactant Metabolism Dysfunction

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17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Surfactant Metabolism Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary alveolar proteinosis32.3SFTPC, SFTPB, CSF2RA
2idiopathic pulmonary fibrosis30.5SFTPB, SFTPC
3congenital pulmonary alveolar proteinosis10.8
4pulmonary alveolar proteinosis acquired10.7
5pulmonary tuberculosis10.6
6tuberculosis10.6
7pulmonary function10.6
8acute leukemia10.5
9lysinuric protein intolerance10.5
10protein s deficiency10.5
11lipoid proteinosis10.5
12abca3-related pulmonary surfactant metabolism dysfunction10.4
13sftpb-related pulmonary surfactant metabolism dysfunction10.4
14sftpc-related pulmonary surfactant metabolism dysfunction10.4
15csf2ra-related pulmonary surfactant metabolism dysfunction10.4
16surfactant metabolism dysfunction, pulmonary, 110.4
17desquamative interstitial pneumonia10.4
18cryptococcosis10.4
19protein c deficiency10.4
20amyloidosis10.4
21arthritis10.4
22squamous cell carcinoma10.4
23al amyloidosis10.4
24protein r deficiency10.4
25rheumatoid lung disease10.4
26surfactant dysfunction10.3
27surfactant metabolism dysfunction, pulmonary, 210.3
28surfactant metabolism dysfunction, pulmonary, 310.3
29surfactant metabolism dysfunction, pulmonary, 510.3
30surfactant metabolism dysfunction, pulmonary, 410.3
31idiopathic pulmonary alveolar proteinosis10.3
32deficiency anemia10.2
33lymphoid leukemia10.2
34protein-deficiency anemia10.2
35niemann-pick disease10.2
36congenital dyserythropoietic anemia10.2
37pulmonary aspergilloma10.2
38fanconi's anemia10.2
39lipid pneumonia10.2
40lymphangioleiomyomatosis10.2
41acute myeloid leukemia10.2
42systemic lupus erythematosus10.2
43acute t cell leukemia10.2
44common variable immunodeficiency10.2
45pulmonary alveolar microlithiasis10.2
46nocardiosis10.2
47bronchiectasis10.2
48acquired immunodeficiency syndrome10.2
49silicosis10.2
50chronic myeloid leukemia10.2

Graphical network of the top 20 diseases related to Pulmonary Surfactant Metabolism Dysfunction:



Diseases related to pulmonary surfactant metabolism dysfunction

Clinical Features for Pulmonary Surfactant Metabolism Dysfunction

Drugs & Therapeutics for Pulmonary Surfactant Metabolism Dysfunction

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Surfactant Metabolism Dysfunction

Search NIH Clinical Center for Pulmonary Surfactant Metabolism Dysfunction

Search CenterWatch for Pulmonary Surfactant Metabolism Dysfunction

Genetic Tests for Pulmonary Surfactant Metabolism Dysfunction

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20GeneTests, 22GTR
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Genetic tests related to Pulmonary Surfactant Metabolism Dysfunction:

id Genetic test Affiliating Genes
1 Pulmonary Surfactant Metabolism Dysfunction20 22 SFTPC

Anatomical Context for Pulmonary Surfactant Metabolism Dysfunction

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Surfactant Metabolism Dysfunction:

33
Lung

Animal Models for Pulmonary Surfactant Metabolism Dysfunction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pulmonary Surfactant Metabolism Dysfunction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8ABCA3, SFTPB, SFTPC

Publications for Pulmonary Surfactant Metabolism Dysfunction

Genetic Variations for Pulmonary Surfactant Metabolism Dysfunction

Expression for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Search GEO for disease gene expression data for Pulmonary Surfactant Metabolism Dysfunction.

Pathways for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Compounds for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1infasurf459.7SFTPB, SFTPC
2dppg459.7SFTPC, SFTPB
3popg459.7SFTPC, SFTPB
41,2-dipalmitoyl-sn-glycero-3-phosphocholine459.7SFTPC, SFTPB
5curosurf459.7SFTPB, SFTPC
6dopc459.6SFTPC, SFTPB
7survanta459.6SFTPC, SFTPB
8dppc459.6SFTPB, SFTPC
9butanol459.6SFTPC, SFTPB
10p-opc459.6SFTPC, SFTPB
11chloroform459.6SFTPB, SFTPC
12methanol45 2410.6SFTPC, SFTPB
13isoleucine459.6SFTPB, SFTPC
14doxycycline45 1110.5SFTPB, SFTPC
15peroxynitrite459.5SFTPC, SFTPB
16bleomycin45 1110.5SFTPB, SFTPC
17palmitate459.4SFTPB, SFTPC
18ibmx45 29 6011.4SFTPC, SFTPB
19phosphatidylcholine459.3SFTPB, SFTPC
20ribonucleic acid459.3SFTPB, SFTPC
21chloramphenicol45 2 1111.0SFTPB, SFTPC
22lipid458.7SFTPC, SFTPB, ABCA3

GO Terms for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Sources:
16Gene Ontology
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Cellular components related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alveolar lamellar bodyGO:0972089.4ABCA3, SFTPC

Biological processes related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.3SFTPB, SFTPC

Products for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Surfactant Metabolism Dysfunction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet