MCID: PLM071
MIFTS: 31

Pulmonary Surfactant Metabolism Dysfunction malady

Genetic diseases, Respiratory diseases, Rare diseases categories
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Summaries for Pulmonary Surfactant Metabolism Dysfunction

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33MalaCards
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MalaCards: Pulmonary Surfactant Metabolism Dysfunction, also known as pulmonary alveolar proteinosis, is related to abca3-related pulmonary surfactant metabolism dysfunction and sftpb-related pulmonary surfactant metabolism dysfunction. An important gene associated with Pulmonary Surfactant Metabolism Dysfunction is SFTPC (surfactant protein C). The compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotype respiratory system.

Aliases & Classifications for Pulmonary Surfactant Metabolism Dysfunction

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62UMLS, 20GeneTests, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary surfactant metabolism dysfunction 20 22
pulmonary alveolar proteinosis 62
lung diseases, interstitial 62


Related Diseases for Pulmonary Surfactant Metabolism Dysfunction

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17GeneCards, 18GeneDecks
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Diseases in the Surfactant Metabolism Dysfunction, Pulmonary, 1 family:

pulmonary surfactant metabolism dysfunction Abca3-Related Pulmonary Surfactant Metabolism Dysfunction
Sftpb-Related Pulmonary Surfactant Metabolism Dysfunction Sftpc-Related Pulmonary Surfactant Metabolism Dysfunction
Csf2ra-Related Pulmonary Surfactant Metabolism Dysfunction Surfactant Metabolism Dysfunction, Pulmonary, 2
Surfactant Metabolism Dysfunction, Pulmonary, 3 Surfactant Metabolism Dysfunction, Pulmonary, 5
Surfactant Metabolism Dysfunction, Pulmonary, 4

Diseases related to Pulmonary Surfactant Metabolism Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1abca3-related pulmonary surfactant metabolism dysfunction10.4
2sftpb-related pulmonary surfactant metabolism dysfunction10.4
3sftpc-related pulmonary surfactant metabolism dysfunction10.4
4csf2ra-related pulmonary surfactant metabolism dysfunction10.4
5surfactant metabolism dysfunction, pulmonary, 110.4
6surfactant dysfunction10.3
7surfactant metabolism dysfunction, pulmonary, 210.3
8surfactant metabolism dysfunction, pulmonary, 310.3
9surfactant metabolism dysfunction, pulmonary, 510.3
10surfactant metabolism dysfunction, pulmonary, 410.3
11idiopathic pulmonary alveolar proteinosis10.3
12large cell carcinoma10.0SFTPC, SFTPB
13interstitial lung disease10.0SFTPC, SFTPB
14adult respiratory distress syndrome10.0SFTPC, SFTPB
15newborn respiratory distress syndrome10.0SFTPC, SFTPB
16primary pulmonary hypertension10.0SFTPB, SFTPC
17idiopathic pulmonary fibrosis10.0SFTPB, SFTPC
18non-small cell lung carcinoma10.0SFTPC, SFTPB
19lung benign neoplasm10.0SFTPB, SFTPC
20pneumonia10.0SFTPC, SFTPB
21lung cancer10.0SFTPB, SFTPC
22lung adenocarcinoma10.0SFTPC, SFTPB
23respiratory failure10.0ABCA3, SFTPB, SFTPC
24cork-handlers' disease10.0ABCA3, SFTPC, SFTPB
25cystic fibrosis10.0SFTPB, SFTPC
26pulmonary alveolar proteinosis9.9CSF2RA, SFTPC, SFTPB

Graphical network of the top 20 diseases related to Pulmonary Surfactant Metabolism Dysfunction:



Diseases related to pulmonary surfactant metabolism dysfunction

Symptoms for Pulmonary Surfactant Metabolism Dysfunction

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Drugs & Therapeutics for Pulmonary Surfactant Metabolism Dysfunction

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Surfactant Metabolism Dysfunction

Search NIH Clinical Center for Pulmonary Surfactant Metabolism Dysfunction

Genetic Tests for Pulmonary Surfactant Metabolism Dysfunction

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20GeneTests, 22GTR
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Genetic tests related to Pulmonary Surfactant Metabolism Dysfunction:

id Genetic test Affiliating Genes
1 Pulmonary Surfactant Metabolism Dysfunction20 22 SFTPC

Anatomical Context for Pulmonary Surfactant Metabolism Dysfunction

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Surfactant Metabolism Dysfunction:

33
Lung

Animal Models for Pulmonary Surfactant Metabolism Dysfunction or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Surfactant Metabolism Dysfunction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8SFTPC, SFTPB, ABCA3

Publications for Pulmonary Surfactant Metabolism Dysfunction

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Variations for Pulmonary Surfactant Metabolism Dysfunction

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Expression for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Search GEO for disease gene expression data for Pulmonary Surfactant Metabolism Dysfunction.

Pathways for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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Compounds for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 51PharmGKB
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Compounds related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1infasurf459.7SFTPC, SFTPB
2popg459.7SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine459.7SFTPB, SFTPC
4dppg459.7SFTPB, SFTPC
5curosurf459.7SFTPC, SFTPB
6survanta459.7SFTPB, SFTPC
7dopc459.7SFTPB, SFTPC
8dppc459.7SFTPC, SFTPB
9p-opc459.7SFTPB, SFTPC
10butanol459.7SFTPB, SFTPC
11chloroform459.6SFTPC, SFTPB
12methanol45 2410.6SFTPC, SFTPB
13isoleucine459.6SFTPC, SFTPB
14doxycycline45 1110.6SFTPB, SFTPC
15peroxynitrite459.6SFTPC, SFTPB
16bleomycin45 1110.6SFTPC, SFTPB
17palmitate459.6SFTPC, SFTPB
18ibmx45 61 2911.6SFTPB, SFTPC
19phosphatidylcholine459.5SFTPC, SFTPB
20chloramphenicol45 3 51 1112.5SFTPB, SFTPC
21ribonucleic acid459.4SFTPC, SFTPB
22fibrinogen459.4SFTPC, SFTPB
23phospholipid459.3SFTPB, SFTPC
24fatty acid459.3SFTPC, SFTPB
25actinomycin d459.2SFTPC, SFTPB
26hydrogen45 2410.0SFTPC, SFTPB
27lipid459.0SFTPC, SFTPB, ABCA3

GO Terms for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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16Gene Ontology
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Cellular components related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alveolar lamellar bodyGO:0972089.1SFTPC, ABCA3
2extracellular spaceGO:0056158.8SFTPC, SFTPB, ABCA3

Biological processes related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:0513849.4SFTPC, ABCA3
2respiratory gaseous exchangeGO:0075859.0SFTPC, SFTPB

Products for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Surfactant Metabolism Dysfunction

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet