MCID: PLM071
MIFTS: 31

Pulmonary Surfactant Metabolism Dysfunction malady

Genetic diseases, Respiratory diseases, Rare diseases categories

Summaries for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Pulmonary Surfactant Metabolism Dysfunction, also known as pulmonary alveolar proteinosis, is related to abca3-related pulmonary surfactant metabolism dysfunction and sftpb-related pulmonary surfactant metabolism dysfunction. An important gene associated with Pulmonary Surfactant Metabolism Dysfunction is SFTPC (surfactant protein C). The compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotype respiratory system.

Aliases & Classifications for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
63UMLS, 21GeneTests, 23GTR
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary surfactant metabolism dysfunction 21 23
pulmonary alveolar proteinosis 63
lung diseases, interstitial 63


Related Diseases for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Surfactant Metabolism Dysfunction, Pulmonary, 1 family:

pulmonary surfactant metabolism dysfunction Abca3-Related Pulmonary Surfactant Metabolism Dysfunction
Sftpb-Related Pulmonary Surfactant Metabolism Dysfunction Sftpc-Related Pulmonary Surfactant Metabolism Dysfunction
Csf2ra-Related Pulmonary Surfactant Metabolism Dysfunction Surfactant Metabolism Dysfunction, Pulmonary, 2
Surfactant Metabolism Dysfunction, Pulmonary, 3 Surfactant Metabolism Dysfunction, Pulmonary, 5
Surfactant Metabolism Dysfunction, Pulmonary, 4

Diseases related to Pulmonary Surfactant Metabolism Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1abca3-related pulmonary surfactant metabolism dysfunction10.4
2sftpb-related pulmonary surfactant metabolism dysfunction10.4
3sftpc-related pulmonary surfactant metabolism dysfunction10.4
4csf2ra-related pulmonary surfactant metabolism dysfunction10.4
5surfactant metabolism dysfunction, pulmonary, 110.4
6surfactant dysfunction10.3
7surfactant metabolism dysfunction, pulmonary, 210.3
8surfactant metabolism dysfunction, pulmonary, 310.3
9surfactant metabolism dysfunction, pulmonary, 510.3
10surfactant metabolism dysfunction, pulmonary, 410.3
11idiopathic pulmonary alveolar proteinosis10.3
12large cell carcinoma10.0SFTPC, SFTPB
13interstitial lung disease10.0SFTPC, SFTPB
14adult respiratory distress syndrome10.0SFTPC, SFTPB
15newborn respiratory distress syndrome10.0SFTPC, SFTPB
16primary pulmonary hypertension10.0SFTPB, SFTPC
17idiopathic pulmonary fibrosis10.0SFTPB, SFTPC
18non-small cell lung carcinoma10.0SFTPC, SFTPB
19lung benign neoplasm10.0SFTPB, SFTPC
20pneumonia10.0SFTPC, SFTPB
21lung cancer10.0SFTPB, SFTPC
22lung adenocarcinoma10.0SFTPC, SFTPB
23respiratory failure10.0ABCA3, SFTPB, SFTPC
24cork-handlers' disease10.0ABCA3, SFTPC, SFTPB
25cystic fibrosis10.0SFTPB, SFTPC
26pulmonary alveolar proteinosis9.9CSF2RA, SFTPC, SFTPB

Graphical network of the top 20 diseases related to Pulmonary Surfactant Metabolism Dysfunction:



Diseases related to pulmonary surfactant metabolism dysfunction

Symptoms for Pulmonary Surfactant Metabolism Dysfunction

About this section

Drugs & Therapeutics for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Surfactant Metabolism Dysfunction

Drug clinical trials:

Search ClinicalTrials for Pulmonary Surfactant Metabolism Dysfunction

Search NIH Clinical Center for Pulmonary Surfactant Metabolism Dysfunction

Search CenterWatch for Pulmonary Surfactant Metabolism Dysfunction

Genetic Tests for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
21GeneTests, 23GTR
See all sources

Genetic tests related to Pulmonary Surfactant Metabolism Dysfunction:

id Genetic test Affiliating Genes
1 Pulmonary Surfactant Metabolism Dysfunction21 23 SFTPC

Anatomical Context for Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pulmonary Surfactant Metabolism Dysfunction:

34
Lung

Animal Models for Pulmonary Surfactant Metabolism Dysfunction or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pulmonary Surfactant Metabolism Dysfunction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8SFTPC, SFTPB, ABCA3

Publications for Pulmonary Surfactant Metabolism Dysfunction

About this section

Variations for Pulmonary Surfactant Metabolism Dysfunction

About this section

Expression for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Search GEO for disease gene expression data for Pulmonary Surfactant Metabolism Dysfunction.

Pathways for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section

Compounds for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 52PharmGKB
See all sources

Compounds related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1infasurf469.7SFTPC, SFTPB
2popg469.7SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine469.7SFTPB, SFTPC
4dppg469.7SFTPB, SFTPC
5curosurf469.7SFTPC, SFTPB
6survanta469.7SFTPB, SFTPC
7dopc469.7SFTPB, SFTPC
8dppc469.7SFTPC, SFTPB
9p-opc469.7SFTPB, SFTPC
10butanol469.7SFTPB, SFTPC
11chloroform469.6SFTPC, SFTPB
12methanol46 2510.6SFTPC, SFTPB
13isoleucine469.6SFTPC, SFTPB
14doxycycline46 1210.6SFTPB, SFTPC
15peroxynitrite469.6SFTPC, SFTPB
16bleomycin46 1210.6SFTPC, SFTPB
17palmitate469.6SFTPC, SFTPB
18ibmx46 62 3011.6SFTPB, SFTPC
19phosphatidylcholine469.5SFTPC, SFTPB
20chloramphenicol46 3 52 1212.5SFTPB, SFTPC
21ribonucleic acid469.4SFTPC, SFTPB
22fibrinogen469.4SFTPC, SFTPB
23phospholipid469.3SFTPB, SFTPC
24fatty acid469.3SFTPC, SFTPB
25actinomycin d469.2SFTPC, SFTPB
26hydrogen46 2510.0SFTPC, SFTPB
27lipid469.0SFTPC, SFTPB, ABCA3

GO Terms for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alveolar lamellar bodyGO:0972089.1SFTPC, ABCA3
2extracellular spaceGO:0056158.8SFTPC, SFTPB, ABCA3

Biological processes related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:0513849.4SFTPC, ABCA3
2respiratory gaseous exchangeGO:0075859.0SFTPC, SFTPB

Products for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Surfactant Metabolism Dysfunction

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet