MCID: PLM071
MIFTS: 28

Pulmonary Surfactant Metabolism Dysfunction malady

Genetic diseases (common), Respiratory diseases, Metabolic diseases categories

Aliases & Classifications for Pulmonary Surfactant Metabolism Dysfunction

About this section

Aliases & Descriptions for Pulmonary Surfactant Metabolism Dysfunction:

Name: Pulmonary Surfactant Metabolism Dysfunction 22 24
Pulmonary Alveolar Proteinosis 22
 
Interstitial Lung Disease 22
Surfactant Dysfunction 65


Classifications:



Summaries for Pulmonary Surfactant Metabolism Dysfunction

About this section
MalaCards based summary: Pulmonary Surfactant Metabolism Dysfunction, also known as pulmonary alveolar proteinosis, is related to pneumothorax and pulmonary fibrosis, idiopathic. An important gene associated with Pulmonary Surfactant Metabolism Dysfunction is SFTPC (Surfactant Protein C), and among its related pathways are Phagosome and FOXA1 transcription factor network. Affiliated tissues include lung, and related mouse phenotype respiratory system.

Related Diseases for Pulmonary Surfactant Metabolism Dysfunction

About this section

Diseases in the Pulmonary Surfactant Metabolism Dysfunction family:

Surfactant Metabolism Dysfunction, Pulmonary, 1 Surfactant Metabolism Dysfunction, Pulmonary, 2
Surfactant Metabolism Dysfunction, Pulmonary, 3 Surfactant Metabolism Dysfunction, Pulmonary, 5
Surfactant Metabolism Dysfunction, Pulmonary, 4 Abca3-Related Pulmonary Surfactant Metabolism Dysfunction
Csf2ra-Related Pulmonary Surfactant Metabolism Dysfunction Sftpb-Related Pulmonary Surfactant Metabolism Dysfunction
Sftpc-Related Pulmonary Surfactant Metabolism Dysfunction

Diseases related to Pulmonary Surfactant Metabolism Dysfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax30.7SFTPB, SFTPC, SFTPD
2pulmonary fibrosis, idiopathic30.6SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD
3lung squamous cell carcinoma30.5SFTPA1, SFTPA2
4pulmonary sarcoidosis30.4SFTPA1, SFTPA2, SFTPC, SFTPD
5diarrhea30.2SFTPB, SFTPC
6aspergillosis30.0SFTPA1, SFTPA2, SFTPD
7acute interstitial pneumonia30.0ABCA3, SFTPA1, SFTPB, SFTPC
8niemann-pick disease29.8ABCA3, NKX2-1, SFTPA1, SFTPA2, SFTPB, SFTPC
9pulmonary alveolar proteinosis11.6
10interstitial lung disease11.5
11dermatomyositis11.0
12connective tissue disease10.9
13secondary pulmonary alveolar proteinosis10.9
14congenital pulmonary alveolar proteinosis10.9
15cork-handlers' disease10.9
16respiratory system disease10.9
17arthritis10.8
18polymyositis10.8
19rheumatoid arthritis10.8
20pulmonary fibrosis10.8
21myelodysplastic syndrome10.8
22leukemia10.8
23hereditary pulmonary alveolar proteinosis10.8
24lung cancer10.8
25scleroderma10.8
26pneumonia10.8
27pulmonary alveolar proteinosis acquired10.8
28amyopathic dermatomyositis10.8
29pulmonary hypertension10.8
30bronchiolitis10.7
31children's interstitial lung disease10.7
32antisynthetase syndrome10.7
33usual interstitial pneumonia10.7
34idiopathic interstitial pneumonia10.6
35myopathy10.6
36interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.5
37diffuse scleroderma10.5
38myositis10.5
39vascular disease10.5
40frontotemporal lobar degeneration with ubiquitin-positive inclusions10.5
41myeloid leukemia10.5
42early-onset pulmonary alveolar proteinosis due to mars deficiency10.5
43surfactant metabolism dysfunction, pulmonary, 110.5
44surfactant metabolism dysfunction, pulmonary, 210.5
45surfactant metabolism dysfunction, pulmonary, 310.5
46surfactant metabolism dysfunction, pulmonary, 510.5
47surfactant metabolism dysfunction, pulmonary, 410.5
48abca3-related pulmonary surfactant metabolism dysfunction10.5
49csf2ra-related pulmonary surfactant metabolism dysfunction10.5
50sftpb-related pulmonary surfactant metabolism dysfunction10.5

Graphical network of the top 20 diseases related to Pulmonary Surfactant Metabolism Dysfunction:



Diseases related to pulmonary surfactant metabolism dysfunction

Symptoms for Pulmonary Surfactant Metabolism Dysfunction

About this section

Drugs & Therapeutics for Pulmonary Surfactant Metabolism Dysfunction

About this section

Drugs for Pulmonary Surfactant Metabolism Dysfunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nitric OxideapprovedPhase 354010102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
2CalfactantPhase 310
3Pulmonary SurfactantsPhase 399
4vitamin d1463

Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric OxideActive, not recruitingNCT00569530Phase 3
2Trial of Late Surfactant for Prevention of Bronchopulmonary DysplasiaActive, not recruitingNCT01022580Phase 3
3The Effect of Maternal and Neonatal Vitamin D Levels on Respiratory Distress Syndrome in Preterm InfantsCompletedNCT02024490

Search NIH Clinical Center for Pulmonary Surfactant Metabolism Dysfunction

Genetic Tests for Pulmonary Surfactant Metabolism Dysfunction

About this section

Genetic tests related to Pulmonary Surfactant Metabolism Dysfunction:

id Genetic test Affiliating Genes
1 Pulmonary Surfactant Metabolism Dysfunction22 24 SFTPC

Anatomical Context for Pulmonary Surfactant Metabolism Dysfunction

About this section

MalaCards organs/tissues related to Pulmonary Surfactant Metabolism Dysfunction:

33
Lung

Animal Models for Pulmonary Surfactant Metabolism Dysfunction or affiliated genes

About this section

MGI Mouse Phenotypes related to Pulmonary Surfactant Metabolism Dysfunction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3ABCA3, CSF2RB, NKX2-1, SFTPB, SFTPC, SFTPD

Publications for Pulmonary Surfactant Metabolism Dysfunction

About this section

Variations for Pulmonary Surfactant Metabolism Dysfunction

About this section

Expression for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section
Search GEO for disease gene expression data for Pulmonary Surfactant Metabolism Dysfunction.

Pathways for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section

Pathways related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2SFTPA1, SFTPA2, SFTPD
2
Show member pathways
9.2SFTPA1, SFTPA2, SFTPD
3
Show member pathways
7.4CSF2RA, CSF2RB, SFTA3, SFTPA1, SFTPA2, SFTPB
4
Show member pathways
5.5CCDC59, CSF2RA, CSF2RB, NKX2-1, SFTA3, SFTPA1
5
Show member pathways
5.5CCDC59, CSF2RA, CSF2RB, NKX2-1, SFTA3, SFTPA1
6
Show member pathways
5.2ABCA3, CCDC59, CSF2RA, CSF2RB, NKX2-1, SFTA3
7
Show member pathways
5.2ABCA3, CCDC59, CSF2RA, CSF2RB, NKX2-1, SFTA3

GO Terms for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

About this section

Cellular components related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1multivesicular body lumenGO:009748610.6SFTPB, SFTPC
2multivesicular bodyGO:000577110.5SFTPB, SFTPC
3alveolar lamellar bodyGO:009720810.3ABCA3, SFTPB, SFTPC
4collagen trimerGO:00055819.1SFTPA1, SFTPA2, SFTPD
5lamellar bodyGO:00425999.0SFTA3, SFTPA1, SFTPA2, SFTPB, SFTPC
6clathrin-coated endocytic vesicleGO:00453348.7SFTA3, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD
7extracellular spaceGO:00056158.4ABCA3, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD
8endoplasmic reticulum membraneGO:00057898.3SFTA3, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD
9extracellular regionGO:00055767.5CSF2RA, SFTA3, SFTPA1, SFTPA2, SFTPB, SFTPC

Biological processes related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:00075858.6CSF2RB, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD
2cellular protein metabolic processGO:00442675.7ABCA3, CCDC59, CSF2RA, CSF2RB, SFTA3, SFTPA1

Molecular functions related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00048969.8CSF2RA, CSF2RB
2carbohydrate bindingGO:00302468.9SFTPA1, SFTPA2, SFTPD

Sources for Pulmonary Surfactant Metabolism Dysfunction

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet