MCID: PLM071
MIFTS: 28

Pulmonary Surfactant Metabolism Dysfunction malady

Respiratory diseases, Metabolic diseases categories

Summaries for Pulmonary Surfactant Metabolism Dysfunction

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MalaCards: Pulmonary Surfactant Metabolism Dysfunction, also known as pulmonary alveolar proteinosis, is related to pulmonary alveolar proteinosis and interstitial lung disease. An important gene associated with Pulmonary Surfactant Metabolism Dysfunction is SFTPC (surfactant protein C). The compounds infasurf and dppg have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotype respiratory system.

Aliases & Classifications for Pulmonary Surfactant Metabolism Dysfunction

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60UMLS, 20GeneTests, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary surfactant metabolism dysfunction 20 22
pulmonary alveolar proteinosis 60
lung diseases, interstitial 60


Related Diseases for Pulmonary Surfactant Metabolism Dysfunction

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17GeneCards, 18GeneDecks
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Diseases in the Surfactant Metabolism Dysfunction, Pulmonary, 1 family:

pulmonary surfactant metabolism dysfunction Abca3-Related Pulmonary Surfactant Metabolism Dysfunction
Sftpb-Related Pulmonary Surfactant Metabolism Dysfunction Sftpc-Related Pulmonary Surfactant Metabolism Dysfunction
Csf2ra-Related Pulmonary Surfactant Metabolism Dysfunction Surfactant Metabolism Dysfunction, Pulmonary, 2
Surfactant Metabolism Dysfunction, Pulmonary, 3 Surfactant Metabolism Dysfunction, Pulmonary, 5
Surfactant Metabolism Dysfunction, Pulmonary, 4

Diseases related to Pulmonary Surfactant Metabolism Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary alveolar proteinosis32.3SFTPC, SFTPB, CSF2RA
2interstitial lung disease31.2SFTPC, SFTPB
3pneumonia31.0SFTPC, SFTPB
4pulmonary fibrosis30.8SFTPC
5lung cancer30.7SFTPB, SFTPC
6respiratory failure30.6SFTPC, ABCA3, SFTPB
7idiopathic pulmonary fibrosis30.5SFTPB, SFTPC
8leukemia10.7
9congenital pulmonary alveolar proteinosis10.7
10pulmonary tuberculosis10.5
11tuberculosis10.5
12acute leukemia10.5
13lysinuric protein intolerance10.5
14pulmonary alveolar proteinosis acquired10.5
15lipoid proteinosis10.4
16abca3-related pulmonary surfactant metabolism dysfunction10.4
17sftpb-related pulmonary surfactant metabolism dysfunction10.4
18sftpc-related pulmonary surfactant metabolism dysfunction10.4
19csf2ra-related pulmonary surfactant metabolism dysfunction10.4
20surfactant metabolism dysfunction, pulmonary, 110.4
21desquamative interstitial pneumonia10.3
22fanconi's anemia10.3
23cryptococcosis10.3
24amyloidosis10.3
25arthritis10.3
26lung squamous cell carcinoma10.3
27mediastinitis10.3
28myeloid leukemia10.3
29pneumothorax10.3
30psoriasis10.3
31squamous cell carcinoma10.3
32rheumatoid lung disease10.3
33surfactant dysfunction10.2
34surfactant metabolism dysfunction, pulmonary, 210.2
35surfactant metabolism dysfunction, pulmonary, 310.2
36surfactant metabolism dysfunction, pulmonary, 510.2
37surfactant metabolism dysfunction, pulmonary, 410.2
38idiopathic pulmonary alveolar proteinosis10.2
39deficiency anemia10.2
40lymphoid leukemia10.2
41niemann-pick disease10.2
42congenital dyserythropoietic anemia10.2
43pulmonary aspergilloma10.2
44lipid pneumonia10.2
45lymphangioleiomyomatosis10.2
46cerebritis10.2
47acute myeloid leukemia10.2
48systemic lupus erythematosus10.2
49common variable immunodeficiency10.2
50pulmonary alveolar microlithiasis10.2

Graphical network of the top 20 diseases related to Pulmonary Surfactant Metabolism Dysfunction:



Diseases related to pulmonary surfactant metabolism dysfunction

Clinical Features for Pulmonary Surfactant Metabolism Dysfunction

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Drugs & Therapeutics for Pulmonary Surfactant Metabolism Dysfunction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Surfactant Metabolism Dysfunction

Search NIH Clinical Center for Pulmonary Surfactant Metabolism Dysfunction

Search CenterWatch for Pulmonary Surfactant Metabolism Dysfunction

Genetic Tests for Pulmonary Surfactant Metabolism Dysfunction

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20GeneTests, 22GTR
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Genetic tests related to Pulmonary Surfactant Metabolism Dysfunction:

id Genetic test Affiliating Genes
1 Pulmonary Surfactant Metabolism Dysfunction20 22 SFTPC

Anatomical Context for Pulmonary Surfactant Metabolism Dysfunction

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Surfactant Metabolism Dysfunction:

32
Lung

Animal Models for Pulmonary Surfactant Metabolism Dysfunction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Surfactant Metabolism Dysfunction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8ABCA3, SFTPB, SFTPC

Publications for Pulmonary Surfactant Metabolism Dysfunction

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Genetic Variations for Pulmonary Surfactant Metabolism Dysfunction

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Expression for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

Search GEO for disease gene expression data for Pulmonary Surfactant Metabolism Dysfunction.

Pathways for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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Compounds for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1infasurf449.7SFTPB, SFTPC
2dppg449.7SFTPC, SFTPB
3popg449.7SFTPC, SFTPB
41,2-dipalmitoyl-sn-glycero-3-phosphocholine449.7SFTPC, SFTPB
5curosurf449.7SFTPB, SFTPC
6dopc449.6SFTPC, SFTPB
7survanta449.6SFTPC, SFTPB
8dppc449.6SFTPB, SFTPC
9butanol449.6SFTPC, SFTPB
10p-opc449.6SFTPC, SFTPB
11chloroform449.6SFTPB, SFTPC
12methanol44 2410.6SFTPC, SFTPB
13isoleucine449.6SFTPB, SFTPC
14doxycycline44 1110.5SFTPB, SFTPC
15peroxynitrite449.5SFTPC, SFTPB
16bleomycin44 1110.5SFTPB, SFTPC
17palmitate449.4SFTPB, SFTPC
18ibmx44 28 5911.4SFTPC, SFTPB
19phosphatidylcholine449.3SFTPB, SFTPC
20ribonucleic acid449.3SFTPB, SFTPC
21chloramphenicol44 2 1111.0SFTPB, SFTPC
22lipid448.7SFTPC, SFTPB, ABCA3

GO Terms for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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16Gene Ontology
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Cellular components related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alveolar lamellar bodyGO:0972089.4ABCA3, SFTPC

Biological processes related to Pulmonary Surfactant Metabolism Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.3SFTPB, SFTPC

Products for genes affiliated with Pulmonary Surfactant Metabolism Dysfunction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Surfactant Metabolism Dysfunction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet