PTB
MCID: PLM001
MIFTS: 63

Pulmonary Tuberculosis (PTB) malady

Summaries for Pulmonary Tuberculosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A tuberculosis that is a contagious disease located in lungs. the infection has symptom fever, has symptom cough, has symptom difficulty in breathing, has symptom inflammatory infiltrations, has symptom formation of tubercles, has symptom caseation, has symptom pleural effusion, and has symptom fibrosis.

MalaCards: Pulmonary Tuberculosis, also known as tuberculosis, pulmonary, is related to tuberculosis and diabetes mellitus, and has symptoms including cough, difficulty in breathing and inflammatory infiltrations. An important gene associated with Pulmonary Tuberculosis is HP (haptoglobin), and among its related pathways are Toll-like receptor signaling pathway and Immune System. The compounds neopterin and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and t cells, and related mouse phenotypes are immune system and tumorigenesis.

Aliases & Classifications for Pulmonary Tuberculosis

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Sources:
8Disease Ontology, 44Novoseek, 38NCBI Bookshelf, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

pulmonary tuberculosis 8
tuberculosis, pulmonary 60
tuberculosis pulmonary 44
ptb 38


External Ids:

Disease Ontology8 DOID:2957
ICD9CM27 011.90, 011, 011.9
MeSH34 D014397
NCIt39 C26899

Related Diseases for Pulmonary Tuberculosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis32.2TLR1, IFNG, IFNGR1, MBL2, HP, CXCL10
2diabetes mellitus30.7HP
3pneumonia30.7MBL2, CXCL10, IL10
4aspergillosis30.6MBL2, IFNG
5sarcoidosis30.6IFNG, IFNGR1, HLA-S, CXCL10, IL2RA, IL12B
6pulmonary sarcoidosis30.6IFNG, IL2RA, IL12B
7hepatitis30.5HP, CXCL10
8leprosy30.5SLC11A1
9rheumatoid arthritis30.2IFNG, MBL2, HP, ADA, SLC11A1, IL12B
10arthritis30.2CXCL10, IL10, SLC11A1, HP, IFNG
11tuberculoid leprosy30.2IFNG, IL2RA, IL10
12extrapulmonary tuberculosis30.2ADA
13paracoccidioidomycosis30.2IL10, CXCL10
14glomerulonephritis30.2MBL2
15lepromatous leprosy30.2IL10, IFNG
16meningitis30.1MBL2, CXCL10, ADA
17pleural tuberculosis30.1IFNG, IL2RA, ADA
18pleurisy30.1ADA, IL2RA
19adenocarcinoma30.1ADA, CXCL10
20peritonitis30.1ADA
21vasculitis30.1MBL2
22aplastic anemia30.1IFNG
23systemic lupus erythematosus29.9IFNG, IFNGR1, MBL2, CXCL10, IL2RA, IL10
24asthma29.9TLR1, IFNG, MBL2, CXCL10, IL2RA, IL10
25hepatitis c29.9IFNG, IFN1@, HP, CXCL10, IL10, IL12B
26leishmaniasis29.9SLC11A1, IL10, IFNGR1, IFNG
27lymphopenia29.9IFNG, IL2RA, IL10, ADA
28allergic asthma29.9IFNG, IFNGR1, IL2RA, IL10
29allergic rhinitis29.9IL10, MBL2, IFNG
30schistosomiasis29.9IL10, IFNGR1, IFNG
31eosinophilia29.9IL10, IL2RA, MBL2, IFNG
32severe acute respiratory syndrome29.9CXCL10
33bronchiolitis obliterans29.9CXCL10
34anaplastic large cell lymphoma29.9IL2RA
35breast cancer29.9ADA, CXCL10, IFNGR1
36cutaneous leishmaniasis29.9IL10, IFNG
37multidrug-resistant tuberculosis10.6
38lung cancer10.5
39laryngeal tuberculosis10.4
40laryngitis10.4
41intestinal tuberculosis10.4
42allergic bronchopulmonary aspergillosis10.4
43hepatic tuberculosis10.4
44silicosis10.4
45anthracosis10.3
46bronchogenic carcinoma10.2
47lymph node tuberculosis10.2
48retinitis10.2
49oral tuberculosis10.2
50nocardiosis10.2

Graphical network of the top 20 diseases related to Pulmonary Tuberculosis:



Diseases related to pulmonary tuberculosis

Clinical Features for Pulmonary Tuberculosis

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8Disease Ontology
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Symptoms:

8 (show all 8)
  • cough
  • difficulty in breathing
  • inflammatory infiltrations
  • formation of tubercles
  • caseation
  • pleural effusion
  • fibrosis
  • fever

Drugs & Therapeutics for Pulmonary Tuberculosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Tuberculosis

Search NIH Clinical Center for Pulmonary Tuberculosis

Search CenterWatch for Pulmonary Tuberculosis

Genetic Tests for Pulmonary Tuberculosis

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Anatomical Context for Pulmonary Tuberculosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Pulmonary Tuberculosis:

32
Lung, T cells, Testes, Monocytes, Lymph node, Skin, Whole blood, Kidney, Heart, Bone, Bone marrow, Liver, Breast, Nk cells, Tongue, Adrenal cortex, Spinal cord, Cortex, Brain

FMA organs/tissues related to Pulmonary Tuberculosis:

14
Lungs

Animal Models for Pulmonary Tuberculosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Tuberculosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0ADA, TLR1, IFNG, IFNGR1, MBL2, HP
2MP:000200610.8IFNGR1, HP, IL10, IL12B, SLC11A1, IFNG
3MP:000539710.7HP, MBL2, IFNGR1, IFNG, CXCL10, IL2RA

Publications for Pulmonary Tuberculosis

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Sources:
50PubMed
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Articles related to Pulmonary Tuberculosis:

(show top 50)    (show all 1202)
idTitleAuthorsYear
1
Treatment outcome monitoring of pulmonary tuberculosis cases notified in France in 2009. (23557945)
2013
2
Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the GeneXpert MTB/RIF assay. (24108610)
2013
3
The role of induced sputum in the diagnosis of pulmonary tuberculosis. (24049254)
2013
4
Nosocomial pulmonary tuberculosis contact investigation in a neonatal intensive care unit. (23739083)
2013
5
Factors associated with health-related quality of life among pulmonary tuberculosis patients in Manila, the Philippines. (24264802)
2013
6
Capreomycin supergenerics for pulmonary tuberculosis treatment: preparation, in vitro, and in vivo characterization. (23220041)
2013
7
Congenital tuberculosis because of misdiagnosed maternal pulmonary tuberculosis during pregnancy. (23883846)
2013
8
Study on Serum Glucose Level among Smear Positive Pulmonary Tuberculosis Patients in Bangladesh. (24292294)
2013
9
Health system delay in pulmonary tuberculosis treatment in a country with an intermediate burden of tuberculosis: a cross-sectional study. (23517315)
2013
10
Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. (23415668)
2013
11
Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality. (24205052)
2013
12
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and 6 h post dose in patients with pulmonary tuberculosis. (24200276)
2013
13
Species and genotypic diversity of non-tuberculous mycobacteria isolated from children investigated for pulmonary tuberculosis in rural Uganda. (23413873)
2013
14
Primary and acquired pyrazinamide resistance in patients with pulmonary tuberculosis treated at a referral hospital in the city of Recife, Brazil. (23288119)
2012
15
An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques: A Prospective Cohort Study among Adolescent TB-Suspects in Uganda. (23304491)
2012
16
Perfusing chemotherapy by percutaneous lung puncture in the treatment of extensive drug resistant pulmonary tuberculosis. (23205288)
2012
17
The relationship between 25-hydroxyvitamin D levels and treatment course of pulmonary tuberculosis. (22749249)
2012
18
Failure to recognize nontuberculous mycobacteria leads to misdiagnosis of chronic pulmonary tuberculosis. (22615839)
2012
19
Diagnostic yield of post-bronchoscopy sputum smear in pulmonary tuberculosis. (22497518)
2012
20
Expression of beta defensin 2 in experimental pulmonary tuberculosis: tentative approach for vaccine development. (22705089)
2012
21
The roles of glutathione, glutathione peroxidase, glutathione reductase and the carbonyl protein in pulmonary and extra pulmonary tuberculosis. (23285430)
2012
22
Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians. (22771610)
2012
23
Morbidity and mortality at five years after initiating Category I treatment among patients with new sputum smear positive pulmonary tuberculosis. (22838205)
2012
24
Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis. (22485222)
2011
25
Lack of association between rs1024611 (-2581 A/G) polymorphism in CC-chemokine Ligand 2 and susceptibility to pulmonary Tuberculosis in Zahedan, Southeast Iran. (22142522)
2011
26
Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects. (21112816)
2011
27
MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa. (18940815)
2009
28
Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis. (18400971)
2008
29
Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. (18931463)
2008
30
Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis. (17396999)
2007
31
Clinical study of deoxyribonucleotidum for adjuvant treatment of pulmonary tuberculosis with hepatic lesion]. (16864110)
2006
32
Pulmonary arteriovenous malformation in a patient with tuberculosis--an association? (16829099)
2006
33
Role of HLA-B51 and HLA-B52 in susceptibility to pulmonary tuberculosis. (16563877)
2006
34
A promotor polymorphism in monocyte chemoattractant is associated with increased susceptibility to pulmonary tuberculosis]. (16828028)
2006
35
Hypercalcemia and multiple osteolytic lesions in a child with disseminated paracoccidioidomycosis and pulmonary tuberculosis]. (16106322)
2005
36
In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis. (15901609)
2005
37
A study on the correlation between HLA-DR genes and susceptibility to pulmonary tuberculosis in a population of Han nationality from southern China]. (15256088)
2004
38
The assessment of IFN-gamma and its regulatory cytokines in the plasma and bronchoalveolar lavage fluid of patients with active pulmonary tuberculosis. (14552571)
2003
39
Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis. (11985512)
2002
40
Diagnostic and prognostic significance of adenosine deaminase in acutely progressive pulmonary tuberculosis]. (11767393)
2001
41
Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice. (10971741)
2000
42
Changes in the production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-2 in relation to the immunity in patients with pulmonary tuberculosis]. (10479931)
1999
43
Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis: molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients. (10027443)
1999
44
Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol. (9167461)
1997
45
Pulmonary infections caused by Mycobacterium malmoense and Mycobacterium tuberculosis: comparison of radiographic features. (8372747)
1993
46
Bronchoalveolar T-lymphocytes and subsets in pulmonary tuberculosis and bronchogenic carcinoma. (2345320)
1990
47
Serodiagnosis of pulmonary & extrapulmonary tuberculosis by enzyme linked immunosorbent assay of IgG antibodies using BCG 'pressate' antigen. (3305327)
1987
48
T4 lymphopenia in patients with active pulmonary tuberculosis. (3874015)
1985
49
Chronic purulent tuberculous empyema and pulmonary tuberculosis treated by decortications and resections. (14481538)
1962
50
A case of neurofibromatosis with elephantiasis neuromatosa, bone changes, and coincident pulmonary tuberculosis. (13253126)
1955

Genetic Variations for Pulmonary Tuberculosis

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Expression for genes affiliated with Pulmonary Tuberculosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Tuberculosis

Search GEO for disease gene expression data for Pulmonary Tuberculosis.

Pathways for genes affiliated with Pulmonary Tuberculosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
See all sources

Pathways related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8TLR1, IFNG, IFNGR1, CXCL10, IL10, IL12B
2
Hide members
10.8TLR1, IFNG, IFNGR1, MBL2, DEFA3, IL2RA
310.8TLR1, IFNG, IFNGR1, IL10, IL12B
4
Hide members
10.8IL12B, IL10, IFNGR1, IFNG, TLR1
5
Hide members
10.8IFNG, IFNGR1, CXCL10, IL2RA, IL12B
6
Hide members
10.7IFNG, IFNGR1, IL2RA, IL10, IL12B
710.7IFNG, IFNGR1, IL2RA, IL10, IL12B
8
Hide members
10.7TLR1, CXCL10, IL2RA, IL10, IL12B
9
Hide members
10.7TLR1, IFNG, IFNGR1, IL2RA
10
Hide members
10.7IFNG, IFNGR1, IL10, IL12B
11
Hide members
10.7KIR2DS1, KIR2DS3, IFNGR1, IFNG
12
Immune response Bacterial infections in normal airways
10.6IFNGR1, IFNG, TLR1
1310.6IFNG, IL2RA, IL12B
14
Hide members
10.6IFNG, IL2RA, IL12B
1510.6IFNG, IFNGR1, CXCL10
1610.6IL12B, IL10, IFNG
1710.6IL12B, IL10, IFNG
1810.6IL12B, IL10, IFNG
19
Hide members
10.6IL2RA, CXCL10, IFNGR1
20
Hide members
10.6IL10, IL2RA, IFNG
2110.6IFNGR1, IFNG
22
Hide members
10.6IL12B, IL2RA
2310.5IL12B
24
Hide members
10.5TLR1

Compounds for genes affiliated with Pulmonary Tuberculosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1neopterin4411.3IL10, IL2RA, CXCL10, ADA, HP, IFNG
2vitamin d4411.3MBL2, HP, CXCL10, IL10, IL12B, SLC11A1
3tuberculin4411.3IL2RA, HP, ADA, IFNG, IL10, MBL2
4vegf4411.3ADA, IL2RA, IL10, CXCL10, HP, MBL2
5ribavirin44 49 1113.3MBL2, ADA, IL10, IFNG, CXCL10, HP
6nitric oxide44 11 2413.3SLC11A1, CXCL10, MBL2, HP, IFNG, IL10
7cyclosporin a44 28 5913.2HP, IFNG, HLA-S, IL2RA, ADA, IL10
8con a4411.2HP, MBL2, IFNG, IL10, IL2RA
92,5-oligoadenylate4411.2IL10, IL2RA, CXCL10, IFNG, ADA
10il 104411.2CXCL10, IFNG, IL10, IL2RA, IL12B
11imiquimod44 28 59 1114.1IFNG, IL12B, IL10, TLR1
12rantes4411.1IFNG, IL12B, IL2RA, MBL2
13lipoteichoic acid4411.1IL12B, MBL2, IL10, TLR1
14polyinosinic-polycytidylic acid4411.1IL12B, CXCL10, IFNG, IL10
15infliximab44 49 1113.1IFNG, CXCL10, IL10, IL2RA
16histamine44 28 2413.1CXCL10, IL2RA, IL10, ADA, IFNG
17peptidoglycan44 2812.1IL12B, TLR1, MBL2, IL10
18ifn-alpha4411.1IFNG, IL2RA, IL10, CXCL10
19chloroquine44 2 49 28 1115.1IL10, IL2RA, CXCL10, HP
20natalizumab44 1112.0IL2RA, IL10, IFNG
21aspartate4411.0MBL2, SLC11A1, ADA
225 aminosalicylic acid4411.0IL12B, IL10, IL2RA
23il-124411.0IFNG, IL12B, IL10
24polymyxin b4411.0MBL2, IL10, IFNG
25tacrolimus44 49 1113.0IL10, IL2RA, CXCL10, IFNG
26okt34411.0IFNG, IL2RA, IL10
27sulfasalazine44 28 49 1114.0HP, IL12B, IL2RA
28poly(i-c)4411.0IL12B, IFNG, CXCL10
29pentoxifylline44 1112.0IL12B
30mycophenolate mofetil44 49 1113.0IL10, IL2RA, IFNG
31prednisolone44 28 1113.0IL2RA, MBL2
32creatinine4411.0IL2RA, CXCL10, MBL2, HP, ADA
33dexamethasone44 49 28 1113.9ADA
34anti-fungal4410.9MBL2, DEFA3, IFNG
35methotrexate44 49 1112.9ADA, IL2RA, IL10, HLA-S
36cyclophosphamide44 49 1112.9IL2RA, MBL2
37tarc4410.9IL10, IFNG, CXCL10
38ivig4410.9IFNG, IL10, IL2RA
39lactose44 1111.9IL2RA, MBL2, HP
40betaseron4410.9IFNG, IL10
41rolipram44 59 2812.9ADA
42ccl344 2811.9IFNG, CXCL10, IL10
43interferon gamma4410.8IFNG, IL10
44rituximab44 49 1112.8HP, IL2RA, IL10
45sodium stibogluconate44 1111.7IFNG, ADA
46allergens4410.7IL10, CXCL10, IFNG
47theophylline44 28 11 2413.6ADA, IL10, IL2RA
48thalidomide44 49 59 1113.6IL10, IL2RA, IFNG
49pentostatin44 59 28 1113.5ADA, IL2RA
50alpha-galactosylceramide4410.3IL10, IFNG

GO Terms for genes affiliated with Pulmonary Tuberculosis

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Sources:
16Gene Ontology
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Cellular components related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7ADA, IL2RA, CXCL10, IFNG
2extracellular spaceGO:00561510.6ADA, IFNG, MBL2, DEFA3, HP, CXCL10

Biological processes related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274211.1SLC11A1, IFNG, MBL2, DEFA3, HP, IL10
2immune responseGO:00695511.0TLR1, CXCL10, IL2RA, KIR3DS1, KIR2DS1
3negative regulation of growth of symbiont in hostGO:04413011.0IL12B, IL10, MBL2, IFNG
4defense response to virusGO:05160711.0IL12B, CXCL10, DEFA3, IFNG
5defense response to protozoanGO:04283210.9IFNG, IL12B, SLC11A1
6cellular response to lipopolysaccharideGO:07122210.9IL12B, IL10, IFNG
7positive regulation of interleukin-6 biosynthetic processGO:04541010.9TLR1, IFNG
8positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
9positive regulation of smooth muscle cell apoptotic processGO:03439310.8IFNG, IL12B
10macrophage activationGO:04211610.8TLR1, SLC11A1
11negative regulation of interleukin-17 productionGO:03270010.8IFNG, IL12B
12inflammatory responseGO:00695410.8TLR1, CXCL10, IL10, SLC11A1
13innate immune responseGO:04508710.7TLR1, MBL2, DEFA3, KIR3DS1, KIR2DS1
14positive regulation of T-helper 1 type immune responseGO:00282710.7SLC11A1, IL12B
15T-helper 1 type immune responseGO:04208810.7IL12B, TLR1
16regulation of interferon-gamma-mediated signaling pathwayGO:06033410.6IFNGR1, IFNG
17natural killer cell activationGO:03010110.5KIR3DS1, IL12B
18positive regulation of osteoclast differentiationGO:04567210.3IL12B, IFNG

Products for genes affiliated with Pulmonary Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet