PTB
MCID: PLM001
MIFTS: 60

Pulmonary Tuberculosis (PTB) malady

Infectious diseases, Respiratory diseases categories

Summaries for Pulmonary Tuberculosis

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A tuberculosis that is a contagious disease located in lungs. the infection has symptom fever, has symptom cough, has symptom difficulty in breathing, has symptom inflammatory infiltrations, has symptom formation of tubercles, has symptom caseation, has symptom pleural effusion, and has symptom fibrosis.

MalaCards: Pulmonary Tuberculosis, also known as tuberculosis, pulmonary, is related to tuberculosis and leprosy, and has symptoms including fever, difficulty in breathing and inflammatory infiltrations. An important gene associated with Pulmonary Tuberculosis is SLC11A1 (solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1), and among its related pathways are Cellular Transformation by HTLV1 and Type II interferon signaling (IFNG). The compounds cellulose acetate and deferoxamine have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and t cells, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Pulmonary Tuberculosis

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Sources:
9Disease Ontology, 46Novoseek, 40NCBI Bookshelf, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

pulmonary tuberculosis 9
tuberculosis, pulmonary 63
tuberculosis pulmonary 46
ptb 40


External Ids:

Disease Ontology9 DOID:2957
NCIt41 C26899
MeSH36 D014397
ICD9CM28 011, 011.90, 011.9

Related Diseases for Pulmonary Tuberculosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pulmonary Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.9SLC11A1, SP110, TLR1, IRGM, ADA, IFNGR1
2leprosy30.8SLC11A1
3aspergillosis30.7IFNG, SFTPA2
4sarcoidosis30.5HLA-S, ADA, IFNGR1, IFNG, IL12B, SLC11A1
5pleurisy30.3ADA
6arthritis30.3IFNG, HP, SLC11A1
7rheumatoid arthritis30.2ADA, IFNG, IL12B, HP, SLC11A1
8pulmonary sarcoidosis30.2IL12B, IFNG
9crohn's disease30.1IRGM
10pleural tuberculosis30.1IFNG, ADA
11schistosomiasis30.0IFNGR1, IFNG
12leishmaniasis30.0SLC11A1, IFNG, IFNGR1
13lymphopenia30.0IFNG, ADA
14atopy30.0SLC11A1, IL12B, IFNG
15hepatitis c30.0IFNG, IL12B, HP
16systemic lupus erythematosus29.9ADA, IFNGR1, IFNG, IL12B
17asthma29.9TLR1, IFNG, IL12B, SLC11A1
18diabetes mellitus10.5
19pneumonia10.5
20lung cancer10.5
21laryngitis10.4
22intestinal tuberculosis10.4
23silicosis10.4
24allergic bronchopulmonary aspergillosis10.4
25hepatitis10.4
26cor pulmonale10.4
27miliary tuberculosis10.3
28anthracosis10.3
29bronchogenic carcinoma10.3
30retinitis10.3
31tuberculoid leprosy10.2
32lepromatous leprosy10.2
33nocardiosis10.2
34paracoccidioidomycosis10.2
35hypercalcemia10.2
36lymph node tuberculosis10.2
37bronchial disease10.2
38glomerulonephritis10.2
39mediastinitis10.2
40type 2 diabetes mellitus10.2
41mycobacterium kansasii10.2
42t-lymphocytopenia10.2
43aneurysm10.2
44hiv-110.2
45neuromyelitis optica10.1
46multidrug-resistant tuberculosis10.1
47laryngeal tuberculosis10.1
48pharyngitis10.1
49melioidosis10.1
50aortitis10.1

Graphical network of the top 20 diseases related to Pulmonary Tuberculosis:



Diseases related to pulmonary tuberculosis

Symptoms for Pulmonary Tuberculosis

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Sources:
9Disease Ontology
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Symptoms:

9 (show all 8)
  • fever
  • difficulty in breathing
  • inflammatory infiltrations
  • formation of tubercles
  • caseation
  • pleural effusion
  • fibrosis
  • cough

Drugs & Therapeutics for Pulmonary Tuberculosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Tuberculosis

Search NIH Clinical Center for Pulmonary Tuberculosis

Search CenterWatch for Pulmonary Tuberculosis

Genetic Tests for Pulmonary Tuberculosis

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Anatomical Context for Pulmonary Tuberculosis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Pulmonary Tuberculosis:

34
Lung, T cells, Testes, Monocytes, Skin, Lymph node, Heart, Whole blood, Kidney, Breast, Nk cells, Bone, Tongue, Spinal cord, Brain, Liver

FMA organs/tissues related to Pulmonary Tuberculosis:

15
Lungs

Animal Models for Pulmonary Tuberculosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Pulmonary Tuberculosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7IFNGR1, IFNG, IL12B, HP, SLC11A1
2MP:00053978.3SLC11A1, HP, IL12B, IFNG, IFNGR1, ADA
3MP:00053877.9SLC11A1, TLR1, IRGM, ADA, IFNGR1, IFNG

Publications for Pulmonary Tuberculosis

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Sources:
53PubMed
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Articles related to Pulmonary Tuberculosis:

(show top 50)    (show all 1034)
idTitleAuthorsYear
1
Pulmonary hemorrhage complicating Goodpasture's disease in the course of pulmonary tuberculosis. (22826144)
2013
2
Diagnostic Utility of QuantiFERON-TB Gold In-Tube in active pulmonary tuberculosis in Nigeria. (24122682)
2013
3
Active Case Finding of Pulmonary Tuberculosis through Screening of Respiratory Symptomatics Using Sputum Microscopy: Is It Time to Change the Paradigm? (23533747)
2013
4
Nitric oxide, carbonyl protein, lipid peroxidation and correlation between antioxidant vitamins in different categories of pulmonary and extra pulmonary tuberculosis. (23613657)
2013
5
Active pulmonary tuberculosis and latent tuberculosis infection among homeless people in Seoul, South Korea: a cross-sectional study. (23914947)
2013
6
Target prioritization and strategy selection for active case-finding of pulmonary tuberculosis: a tool to support country-level project planning. (23374118)
2013
7
Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population. (24176007)
2013
8
Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India. (24339482)
2013
9
A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults. (23652030)
2013
10
Efficacy and safety of recombinant Mycobacterium tuberculosis ESAT-6 protein for diagnosis of pulmonary tuberculosis: a phase II trial. (24217560)
2013
11
Epidemiology of extra-pulmonary tuberculosis in Israel, 1999-2010. (23317959)
2013
12
A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis treated at home in China. (23337789)
2012
13
Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis. (22866301)
2012
14
Pulmonary tuberculosis mimicking metastasis in a patient with osteosarcoma. (22935666)
2012
15
Multidrug-resistant pulmonary tuberculosis: surgical challenges. (22789592)
2012
16
Primary and acquired pyrazinamide resistance in patients with pulmonary tuberculosis treated at a referral hospital in the city of Recife, Brazil. (23288119)
2012
17
Rapid molecular diagnosis of pulmonary tuberculosis in children using nasopharyngeal specimens. (22752518)
2012
18
Independent association of younger age with hemoptysis in adults with pulmonary tuberculosis. (22583746)
2012
19
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
20
Relationship between single nucleotide polymorphism of interleukin-18 and susceptibility to pulmonary tuberculosis in the Chinese Han population. (21395662)
2011
21
Prevalence of multidrug-resistant tuberculosis among newly diagnosed cases of sputum-positive pulmonary tuberculosis. (21441685)
2011
22
Differential combination of cytokine and interferon- I^ +874 T/A polymorphisms determines disease severity in pulmonary tuberculosis. (22140472)
2011
23
Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis. (21655745)
2011
24
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (19771452)
2010
25
FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia. (20739773)
2010
26
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
27
Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (19799150)
2009
28
NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. (19575238)
2009
29
Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. (19199550)
2009
30
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
31
Simultaneous occurrence of pulmonary tuberculosis and carcinomatous lymphangitis. (17486260)
2007
32
Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients. (17449323)
2007
33
Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. (15525561)
2004
34
Monocyte cytokine secretion in patients with pulmonary tuberculosis differs from that of healthy infected subjects and correlates with clinical manifestations. (14738890)
2004
35
Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis. (12507823)
2003
36
Prediction of the effectiveness of preoperative preparation of patients with fibro-cavernous pulmonary tuberculosis]. (12774420)
2003
37
Circulating levels of stromal cell-derived factor 1alpha and interleukin 7 in HIV type 1 infection and pulmonary tuberculosis are reciprocally related to CXCR4 expression on peripheral blood leukocytes. (12882655)
2003
38
Serum adenosine deaminase activity in pulmonary tuberculosis]. (15143406)
2003
39
Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. (12069029)
2002
40
HLA-DR2 subtypes & immune responses in pulmonary tuberculosis. (11558319)
2001
41
Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis]. (10900981)
2000
42
Changes in the production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-2 in relation to the immunity in patients with pulmonary tuberculosis]. (10479931)
1999
43
In vivo platelet and T-lymphocyte activities during pulmonary tuberculosis. (9877494)
1998
44
Cytokine gene expression profile of circulating CD4+ T cells in active pulmonary tuberculosis. (9118695)
1997
45
Increased production of hydrogen peroxide and expression of CD11b/CD18 on alveolar macrophages in patients with active pulmonary tuberculosis. (8959153)
1996
46
Pulmonary tuberculosis with anthracosis: an unusual diagnosis by fine needle aspiration cytology. (8328256)
1993
47
Rapidly progressive glomerulonephritis and pulmonary tuberculosis. (2020362)
1991
48
Nocardiosis mimicking pulmonary tuberculosis in Ugandan AIDS patients. (1889302)
1991
49
Pulmonary hypertrophic osteoarthropathy (periostitis); its absence in pulmonary tuberculosis. (13552924)
1958
50
Pellagra occurring in Africans under treatment for pulmonary tuberculosis. (13548066)
1958

Variations for Pulmonary Tuberculosis

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Expression for genes affiliated with Pulmonary Tuberculosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Tuberculosis

Search GEO for disease gene expression data for Pulmonary Tuberculosis.

Pathways for genes affiliated with Pulmonary Tuberculosis

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 55R&D Systems
See all sources

Pathways related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9IFNG, IFNGR1
29.9IFNGR1, IFNG
39.7IFNG, IL12B
49.7IL12B, IFNG
59.7IL12B, IFNG
69.7IFNG, IL12B
79.7IL12B, IFNG
8
Show member pathways
Immune response CD16 signaling in NK cells61
9.6KIR2DS3, IFNG, IFNGR1
9
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5IFNG, IFNGR1, TLR1
10
Show member pathways
9.5IFNG, IFNGR1, TLR1
119.5TLR1, IFNGR1, IFNG
12
Show member pathways
Type III interferon signaling39
9.5IL12B, IFNG, IFNGR1
13
Show member pathways
9.5IL12B, IFNG, IFNGR1
14
Show member pathways
9.3TLR1, IFNG, IL12B
15
Show member pathways
9.2IRGM, IFNGR1, IFNG, IL12B
16
Show member pathways
9.2IFNGR1, IFNG, IL12B, KIR2DS3
17
Show member pathways
IL27-mediated signaling events39
9.1IL12B, IFNG, IFNGR1, TLR1
18
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1IL12B, IFNG, IFNGR1, TLR1
199.1IL12B, IFNG, IFNGR1, TLR1

Compounds for genes affiliated with Pulmonary Tuberculosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1cellulose acetate4610.2ADA, HP
2deferoxamine46 1211.2HP, IFNGR1
3con a4610.1HP, IFNG
4sodium stibogluconate46 1211.1IFNG, ADA
5amphotericin b4610.1IFNG, ADA
6sulfasalazine30 46 52 1213.1IL12B, HP
7niacin46 1211.1ADA, HP
8il-124610.0IL12B, IFNG
92,5-oligoadenylate4610.0ADA, IFNG
10lipoteichoic acid469.9TLR1, IL12B
11tuberculin469.9HP, IFNG, ADA
12ribavirin46 52 1211.9ADA, IFNG, HP
13neopterin469.9ADA, IFNG, HP
14polyinosinic-polycytidylic acid469.8IFNG, IL12B
15pentoxifylline46 1210.8HP, IL12B, IFNG
16endotoxin469.8IFNG, IL12B, HP
17il 10469.7IL12B, IFNG
18rolipram46 62 3011.7IFNG, ADA
19imiquimod46 62 30 1212.7IL12B, IFNG, TLR1
20vitamin d469.6IL12B, HP, SLC11A1
21poly(i-c)469.4IL12B, IFNG
22cyclosporin a46 30 6211.3HP, IFNG, ADA, HLA-S
23nitric oxide46 25 1211.3SLC11A1, HP, IL12B, IFNG

GO Terms for genes affiliated with Pulmonary Tuberculosis

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Sources:
17Gene Ontology
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Cellular components related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.5SLC11A1, IRGM, TLR1
2integral component of plasma membraneGO:0058878.8SLC11A1, KIR3DS1, KIR2DS3, IFNGR1, TLR1
3extracellular spaceGO:0056158.3SFTPA2, ADA, IFNG, IL12B, HP

Biological processes related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1macrophage activationGO:04211610.2SLC11A1, TLR1
2regulation of interferon-gamma-mediated signaling pathwayGO:06033410.1IFNG, IFNGR1
3positive regulation of T-helper 1 type immune responseGO:00282710.1IL12B, SLC11A1
4protein import into nucleus, translocationGO:00006010.1SLC11A1, IFNG
5positive regulation of interleukin-6 biosynthetic processGO:04541010.1TLR1, IFNG
6positive regulation of smooth muscle cell apoptotic processGO:03439310.1IFNG, IL12B
7negative regulation of interleukin-17 productionGO:03270010.0IL12B, IFNG
8defense response to Gram-negative bacteriumGO:05082910.0SLC11A1, IL12B
9negative regulation of growth of symbiont in hostGO:04413010.0IFNG, IL12B
10positive regulation of osteoclast differentiationGO:04567210.0IFNG, IL12B
11defense response to bacteriumGO:0427429.9SLC11A1, HP, IFNG
12positive regulation of interleukin-12 productionGO:0327359.9IFNG, IL12B
13negative regulation of smooth muscle cell proliferationGO:0486629.9IL12B, IFNG
14natural killer cell activationGO:0301019.9KIR3DS1, IL12B
15positive regulation of cell adhesionGO:0457859.8IFNG, IL12B
16positive regulation of interferon-gamma productionGO:0327299.8SLC11A1, IL12B
17defense response to protozoanGO:0428329.8SLC11A1, IL12B, IFNG
18response to hydrogen peroxideGO:0425429.8ADA, HP
19positive regulation of tumor necrosis factor productionGO:0327609.8IFNG, IL12B
20inflammatory responseGO:0069549.6SLC11A1, IRGM, TLR1
21positive regulation of T cell proliferationGO:0421029.4IL12B, IFNG

Products for genes affiliated with Pulmonary Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Tuberculosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet