PTB
MCID: PLM001
MIFTS: 62

Pulmonary Tuberculosis (PTB) malady

Summaries for Pulmonary Tuberculosis

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A tuberculosis that is a contagious disease located in lungs. the infection has symptom fever, has symptom cough, has symptom difficulty in breathing, has symptom inflammatory infiltrations, has symptom formation of tubercles, has symptom caseation, has symptom pleural effusion, and has symptom fibrosis.

MalaCards: Pulmonary Tuberculosis, also known as tuberculosis, pulmonary, is related to tuberculosis and aspergillosis, and has symptoms including cough, fever and difficulty in breathing. An important gene associated with Pulmonary Tuberculosis is HP (haptoglobin), and among its related pathways are Toll-like receptor signaling pathway and Immune System. The compounds neopterin and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include lungs, skin and liver, and related mouse phenotypes are immune system and tumorigenesis.

Aliases & Classifications for Pulmonary Tuberculosis

Sources:
8Disease Ontology, 45Novoseek, 39NCBI Bookshelf, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

pulmonary tuberculosis 8
tuberculosis, pulmonary 61
tuberculosis pulmonary 45
ptb 39


External Ids:

Disease Ontology8 DOID:2957
ICD9CM27 011.90, 011, 011.9
MeSH35 D014397
NCIt40 C26899

Related Diseases for Pulmonary Tuberculosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis32.2ADA, SP110, SLC11A1, IL12B, IL10, IL2RA
2aspergillosis30.6IFNG, MBL2
3pulmonary sarcoidosis30.6IFNG, IL2RA, IL12B
4arthritis30.3IFNG, HP, CXCL10, IL10, SLC11A1
5tuberculoid leprosy30.3IFNG, IL2RA, IL10
6paracoccidioidomycosis30.3IL10, CXCL10
7lepromatous leprosy30.3IFNG, IL10
8pleural tuberculosis30.1IFNG, IL2RA, ADA
9adenocarcinoma30.1ADA, CXCL10
10vasculitis30.1MBL2
11aplastic anemia30.1IFNG
12hepatitis b30.0IFN1@, IFNG, CXCL10, MBL2
13systemic lupus erythematosus29.9MBL2, ADA, IL12B, CXCL10, IL2RA, IL10
14asthma29.9SLC11A1, TLR1, IFNG, MBL2, IL2RA, IL12B
15hepatitis c29.9IFNG, IL12B, IL10, CXCL10, HP, IFN1@
16atopy29.9IL12B, IFNG, IL10, SLC11A1
17allergic asthma29.9IFNG, IFNGR1, IL2RA, IL10
18allergic rhinitis29.9IFNG, MBL2, IL10
19severe acute respiratory syndrome29.9CXCL10
20bronchiolitis obliterans29.9CXCL10
21anaplastic large cell lymphoma29.9IL2RA
22cutaneous leishmaniasis29.9IL10, IFNG
23pulmonary function10.6
24multidrug-resistant tuberculosis10.5
25intestinal tuberculosis10.4
26allergic bronchopulmonary aspergillosis10.4
27silicosis10.4
28anthracosis10.3
29bronchogenic carcinoma10.3
30lymph node tuberculosis10.3
31hepatic tuberculosis10.2
32oral tuberculosis10.2
33nocardiosis10.2
34miliary tuberculosis10.2
35hypercalcemia10.2
36hepatitis a10.2
37t-lymphocytopenia10.2
38mycobacterium kansasii10.2
39marfan syndrome10.1
40laryngeal tuberculosis10.1
41neuromyelitis optica10.1
42pulmonary aspergilloma10.1
43interstitial emphysema10.1
44rapidly progressive glomerulonephritis10.1
45tuberculous peritonitis10.1
46aortitis10.1
47melioidosis10.1
48paragonimiasis10.1
49actinomycosis10.1
50asbestosis10.1

Graphical network of the top 20 diseases related to Pulmonary Tuberculosis:



Diseases related to pulmonary tuberculosis

Clinical Features for Pulmonary Tuberculosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 8)
  • cough
  • fever
  • difficulty in breathing
  • inflammatory infiltrations
  • formation of tubercles
  • caseation
  • pleural effusion
  • fibrosis

Drugs & Therapeutics for Pulmonary Tuberculosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Tuberculosis

Search NIH Clinical Center for Pulmonary Tuberculosis

Search CenterWatch for Pulmonary Tuberculosis

Genetic Tests for Pulmonary Tuberculosis

Anatomical Context for Pulmonary Tuberculosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Pulmonary Tuberculosis:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Cortex, Heart, Small intestine, Breast, Monocytes, Nk cells, T cells, B cells, Fetal brain, Fetal liver, Fetal lung, Adrenal cortex

FMA organs/tissues related to Pulmonary Tuberculosis:

14
Lungs

Animal Models for Pulmonary Tuberculosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Tuberculosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0ADA, TLR1, IFNG, IFNGR1, MBL2, HP
2MP:000200610.8IFNGR1, HP, IL10, IL12B, SLC11A1, IFNG
3MP:000539710.7HP, MBL2, IFNGR1, IFNG, CXCL10, IL2RA

Publications for Pulmonary Tuberculosis

Sources:
51PubMed
See all sources

Articles related to Pulmonary Tuberculosis:

(show top 50)    (show all 1202)
idTitleAuthorsYear
1
Particulate air pollution and susceptibility to the development of pulmonary tuberculosis disease in North Carolina: an ecological study. (24387197)
2014
2
Levels of tuberculosis treatment adherence among sputum smear positive pulmonary tuberculosis patients attending care at Zomba Central hospital, southern Malawi, 2007-2008. (23723972)
2013
3
Spontaneous pneumopericardium an unusual complication in a patient of HIV and pulmonary tuberculosis. (23741097)
2013
4
Distribution of HLA-A, B and DRB1 alleles in Sahariya tribe of North Central India: An association with pulmonary tuberculosis. (23994122)
2013
5
Increased risk of pulmonary tuberculosis in patients with previous non-tuberculous mycobacterial disease. (23743312)
2013
6
Hepatitis C Virus Co-Infection Increases the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity among Patients with Pulmonary Tuberculosis. (24367617)
2013
7
The role of video-assisted thoracoscopic surgery in therapeutic lung resection for pulmonary tuberculosis. (23200234)
2013
8
Incremental value of T-SPOT.TB for diagnosis of active pulmonary tuberculosis in children in a high-burden setting: a multivariable analysis. (23674550)
2013
9
Circulating biomarkers of pulmonary and extrapulmonary tuberculosis in children. (23486418)
2013
10
Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS. (24339194)
2013
11
Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon I^-producing T cells from apoptosis in patients with pulmonary tuberculosis. (23661793)
2013
12
Non-adherence of new pulmonary tuberculosis patients to anti-tuberculosis treatment. (23634333)
2013
13
Testicular tuberculosis in multidrug-resistant pulmonary tuberculosis. (23111433)
2013
14
Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis. (23527127)
2013
15
A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis treated at home in China. (23337789)
2012
16
A molecular approach to identification and profiling of first-line-drug-resistant mycobacteria from sputum of pulmonary tuberculosis patients. (22461679)
2012
17
Prevalence of pulmonary tuberculosis among HIV infected persons in Pokhara, Nepal. (22929634)
2012
18
Pattern of drug-resistance and treatment outcome in multidrug-resistant pulmonary tuberculosis. (22779119)
2012
19
Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis. (22719887)
2012
20
Survival among patients with HIV infection and smear-negative pulmonary tuberculosis - United States, 1993-2006. (23110113)
2012
21
An unusual presentation of pulmonary cryptococcosis with co-existing disseminated tuberculosis in an AIDS patient. (22290112)
2012
22
Cavitating pulmonary tuberculosis: a global challenge. (22783790)
2012
23
Pulmonary langerhans cell histiocytosis masquerading as tuberculosis in an infant. (22041471)
2011
24
Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis. (20145387)
2010
25
Role of surgery in pulmonary multidrug-resistant tuberculosis. (17468453)
2007
26
Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva]. (17722288)
2007
27
CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. (18008256)
2007
28
The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis. (17705850)
2007
29
Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. (17347558)
2007
30
The value of serum interferon-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis. (16615013)
2006
31
VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study. (15141734)
2004
32
Six-month therapy with aerosolized interferon-gamma for refractory multidrug-resistant pulmonary tuberculosis. (15082886)
2004
33
Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. (15295697)
2004
34
Circulating levels of stromal cell-derived factor 1alpha and interleukin 7 in HIV type 1 infection and pulmonary tuberculosis are reciprocally related to CXCR4 expression on peripheral blood leukocytes. (12882655)
2003
35
Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis. (12702550)
2003
36
Dynamics of cytokine generation in patients with active pulmonary tuberculosis. (12821809)
2003
37
Changes of plasma interleukin-1 receptor antagonist, interleukin-8 and other serologic markers during chemotherapy in patients with active pulmonary tuberculosis. (14619382)
2003
38
Evaluation of an in-house-developed radioassay kit for antibody detection in cases of pulmonary tuberculosis and tuberculous meningitis. (12204948)
2002
39
Paradoxical emergence of humerus osteomyelitis during treatment of pulmonary and lymph-node tuberculosis. (11234988)
2001
40
Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis: essential role of IL-1 from infected monocytes in a NF-kappa B-dependent network. (10490995)
1999
41
Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis. (10391871)
1999
42
Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis. (8564135)
1996
43
Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis. (8521296)
1995
44
ELISA method for evaluation of anti-A60 IgG in patients with pulmonary and extrapulmonary tuberculosis. (8127228)
1994
45
Pulmonary function and immunologic abnormalities in miliary tuberculosis. (1586062)
1992
46
Expression of functional interleukin 2 receptors by peripheral blood monocytes from patients with active pulmonary tuberculosis. (2347912)
1990
47
Management of pulmonary aspergilloma in the presence of active tuberculosis. (6390774)
1984
48
Pulmonary tuberculosis following successful treatment of pulmonary infection with Mycobacterium kansasii. (1001062)
1976
49
Abdominal tuberculosis. I. pulmonary findings of the abdominal tuberculous patients who have received laparotomy. (14825561)
1950
50
One half gram of streptomycin in the treatment of pulmonary and extrapulmonary tuberculosis; report of 120 cases. (18114651)
1949

Genetic Variations for Pulmonary Tuberculosis

Expression for genes affiliated with Pulmonary Tuberculosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Tuberculosis

Search GEO for disease gene expression data for Pulmonary Tuberculosis.

Pathways for genes affiliated with Pulmonary Tuberculosis

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 53R&D Systems, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8TLR1, IFNG, IFNGR1, CXCL10, IL10, IL12B
2
Hide members
10.8TLR1, IFNG, IFNGR1, MBL2, DEFA3, IL2RA
310.8TLR1, IFNG, IFNGR1, IL10, IL12B
4
Hide members
10.8IL12B, IL10, IFNGR1, IFNG, TLR1
5
Hide members
10.8IFNG, IFNGR1, CXCL10, IL2RA, IL12B
6
Hide members
10.7IFNG, IFNGR1, IL2RA, IL10, IL12B
710.7IFNG, IFNGR1, IL2RA, IL10, IL12B
8
Hide members
10.7TLR1, CXCL10, IL2RA, IL10, IL12B
9
Hide members
10.7TLR1, IFNG, IFNGR1, IL2RA
10
Hide members
10.7IFNG, IFNGR1, IL10, IL12B
11
Hide members
10.7KIR2DS1, KIR2DS3, IFNGR1, IFNG
12
Immune response Bacterial infections in normal airways
10.6IFNGR1, IFNG, TLR1
1310.6IFNG, IL2RA, IL12B
14
Hide members
10.6IFNG, IL2RA, IL12B
1510.6IFNG, IFNGR1, CXCL10
1610.6IL12B, IL10, IFNG
1710.6IL12B, IL10, IFNG
1810.6IL12B, IL10, IFNG
19
Hide members
10.6IL2RA, CXCL10, IFNGR1
20
Hide members
10.6IL10, IL2RA, IFNG
2110.6IFNGR1, IFNG
22
Hide members
10.6IL12B, IL2RA
2310.5IL12B
24
Hide members
10.5TLR1

Compounds for genes affiliated with Pulmonary Tuberculosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1neopterin4511.3IFNG, MBL2, HP, CXCL10, IL2RA, IL10
2vitamin d4511.3MBL2, HP, CXCL10, IL2RA, IL10, IL12B
3tuberculin4511.3ADA, IL10, IL2RA, HP, MBL2, IFNG
4vegf4511.3IFNG, MBL2, HP, CXCL10, IL2RA, IL10
5ribavirin45 50 1113.3IFNG, MBL2, HP, CXCL10, IL10, ADA
6nitric oxide45 11 2413.3IFNG, MBL2, HP, CXCL10, IL10, IL12B
7cyclosporin a45 29 6013.2IFNG, HLA-S, HP, IL2RA, IL10, ADA
8con a4511.2IFNG, MBL2, HP, IL2RA, IL10
92,5-oligoadenylate4511.2IFNG, CXCL10, IL2RA, IL10, ADA
10il 104511.2IFNG, CXCL10, IL2RA, IL10, IL12B
11imiquimod45 29 60 1114.1TLR1, IFNG, IL10, IL12B
12rantes4511.1IFNG, MBL2, IL2RA, IL12B
13lipoteichoic acid4511.1IL12B, IL10, MBL2, TLR1
14polyinosinic-polycytidylic acid4511.1IFNG, CXCL10, IL10, IL12B
15infliximab45 50 1113.1IFNG, CXCL10, IL2RA, IL10
16histamine45 29 2413.1IFNG, CXCL10, IL2RA, IL10, ADA
17peptidoglycan45 2912.1IL12B, IL10, MBL2, TLR1
18ifn-alpha4511.1IFNG, CXCL10, IL2RA, IL10
19chloroquine45 2 50 29 1115.1HP, CXCL10, IL2RA, IL10
20natalizumab45 1112.0IFNG, IL2RA, IL10
21aspartate4511.0ADA, SLC11A1, MBL2
22il-124511.0IFNG, IL10, IL12B
235 aminosalicylic acid4511.0IL2RA, IL10, IL12B
24polymyxin b4511.0IFNG, MBL2, IL10
25tacrolimus45 50 1113.0IL10, IL2RA, CXCL10, IFNG
26okt34511.0IL10, IL2RA, IFNG
27sulfasalazine45 29 50 1114.0HP, IL2RA, IL12B
28poly(i-c)4511.0IFNG, CXCL10, IL12B
29pentoxifylline45 1112.0IL12B
30mycophenolate mofetil45 50 1113.0IFNG, IL2RA, IL10
31prednisolone45 29 1113.0IL2RA, MBL2
32creatinine4511.0MBL2, HP, CXCL10, IL2RA, ADA
33dexamethasone45 50 29 1113.9ADA
34anti-fungal4510.9IFNG, MBL2, DEFA3
35methotrexate45 50 1112.9ADA, IL10, IL2RA, HLA-S
36cyclophosphamide45 50 1112.9IL2RA, MBL2
37tarc4510.9IFNG, CXCL10, IL10
38ivig4510.9IL10, IL2RA, IFNG
39lactose45 1111.9MBL2, HP, IL2RA
40betaseron4510.9IL10, IFNG
41rolipram45 60 2912.9ADA
42ccl345 2911.9IFNG, CXCL10, IL10
43interferon gamma4510.8IFNG, IL10
44rituximab45 50 1112.8IL10, IL2RA, HP
45sodium stibogluconate45 1111.7IFNG, ADA
46allergens4510.7IFNG, CXCL10, IL10
47theophylline45 29 11 2413.6ADA, IL10, IL2RA
48thalidomide45 50 60 1113.6IL10, IL2RA, IFNG
49pentostatin45 60 29 1113.5IL2RA, ADA
50alpha-galactosylceramide4510.3IL10, IFNG

GO Terms for genes affiliated with Pulmonary Tuberculosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7ADA, IL2RA, CXCL10, IFNG
2extracellular spaceGO:00561510.6ADA, IFNG, MBL2, DEFA3, HP, CXCL10

Biological processes related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274211.1SLC11A1, IFNG, MBL2, DEFA3, HP, IL10
2immune responseGO:00695511.0TLR1, CXCL10, IL2RA, KIR3DS1, KIR2DS1
3negative regulation of growth of symbiont in hostGO:04413011.0IL12B, IL10, MBL2, IFNG
4defense response to virusGO:05160711.0IL12B, CXCL10, DEFA3, IFNG
5defense response to protozoanGO:04283210.9IFNG, IL12B, SLC11A1
6cellular response to lipopolysaccharideGO:07122210.9IL12B, IL10, IFNG
7positive regulation of interleukin-6 biosynthetic processGO:04541010.9TLR1, IFNG
8positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
9positive regulation of smooth muscle cell apoptotic processGO:03439310.8IFNG, IL12B
10macrophage activationGO:04211610.8TLR1, SLC11A1
11negative regulation of interleukin-17 productionGO:03270010.8IFNG, IL12B
12inflammatory responseGO:00695410.8TLR1, CXCL10, IL10, SLC11A1
13innate immune responseGO:04508710.7TLR1, MBL2, DEFA3, KIR3DS1, KIR2DS1
14positive regulation of T-helper 1 type immune responseGO:00282710.7SLC11A1, IL12B
15T-helper 1 type immune responseGO:04208810.7IL12B, TLR1
16regulation of interferon-gamma-mediated signaling pathwayGO:06033410.6IFNGR1, IFNG
17natural killer cell activationGO:03010110.5KIR3DS1, IL12B
18positive regulation of osteoclast differentiationGO:04567210.3IL12B, IFNG

Products for genes affiliated with Pulmonary Tuberculosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Tuberculosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet