PTB
MCID: PLM001
MIFTS: 63

Pulmonary Tuberculosis (PTB) malady

Summaries for Pulmonary Tuberculosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A tuberculosis that is a contagious disease located in lungs. the infection has symptom fever, has symptom cough, has symptom difficulty in breathing, has symptom inflammatory infiltrations, has symptom formation of tubercles, has symptom caseation, has symptom pleural effusion, and has symptom fibrosis.

MalaCards: Pulmonary Tuberculosis, also known as tuberculosis, pulmonary, is related to tuberculosis and diabetes mellitus, and has symptoms including cough, difficulty in breathing and inflammatory infiltrations. An important gene associated with Pulmonary Tuberculosis is HP (haptoglobin), and among its related pathways are Toll-like receptor signaling pathway and Immune System. The compounds neopterin and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and t cells, and related mouse phenotypes are immune system and tumorigenesis.

Aliases & Classifications for Pulmonary Tuberculosis

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8Disease Ontology, 44Novoseek, 38NCBI Bookshelf, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

pulmonary tuberculosis 8
tuberculosis, pulmonary 60
tuberculosis pulmonary 44
ptb 38


External Ids:

Disease Ontology8 DOID:2957
ICD9CM27 011.90, 011, 011.9
MeSH34 D014397
NCIt39 C26899

Related Diseases for Pulmonary Tuberculosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis32.2TLR1, IFNG, IFNGR1, MBL2, HP, CXCL10
2diabetes mellitus30.7HP
3pneumonia30.7MBL2, CXCL10, IL10
4aspergillosis30.6MBL2, IFNG
5sarcoidosis30.6IFNG, IFNGR1, HLA-S, CXCL10, IL2RA, IL12B
6pulmonary sarcoidosis30.6IFNG, IL2RA, IL12B
7hepatitis30.5HP, CXCL10
8leprosy30.5SLC11A1
9rheumatoid arthritis30.2IFNG, MBL2, HP, ADA, SLC11A1, IL12B
10arthritis30.2CXCL10, IL10, SLC11A1, HP, IFNG
11tuberculoid leprosy30.2IFNG, IL2RA, IL10
12extrapulmonary tuberculosis30.2ADA
13paracoccidioidomycosis30.2IL10, CXCL10
14glomerulonephritis30.2MBL2
15lepromatous leprosy30.2IL10, IFNG
16meningitis30.1MBL2, CXCL10, ADA
17pleural tuberculosis30.1IFNG, IL2RA, ADA
18pleurisy30.1ADA, IL2RA
19adenocarcinoma30.1ADA, CXCL10
20peritonitis30.1ADA
21vasculitis30.1MBL2
22aplastic anemia30.1IFNG
23systemic lupus erythematosus29.9IFNG, IFNGR1, MBL2, CXCL10, IL2RA, IL10
24asthma29.9TLR1, IFNG, MBL2, CXCL10, IL2RA, IL10
25hepatitis c29.9IFNG, IFN1@, HP, CXCL10, IL10, IL12B
26leishmaniasis29.9SLC11A1, IL10, IFNGR1, IFNG
27lymphopenia29.9IFNG, IL2RA, IL10, ADA
28allergic asthma29.9IFNG, IFNGR1, IL2RA, IL10
29allergic rhinitis29.9IL10, MBL2, IFNG
30schistosomiasis29.9IL10, IFNGR1, IFNG
31eosinophilia29.9IL10, IL2RA, MBL2, IFNG
32severe acute respiratory syndrome29.9CXCL10
33bronchiolitis obliterans29.9CXCL10
34anaplastic large cell lymphoma29.9IL2RA
35breast cancer29.9ADA, CXCL10, IFNGR1
36cutaneous leishmaniasis29.9IL10, IFNG
37multidrug-resistant tuberculosis10.6
38lung cancer10.5
39laryngeal tuberculosis10.4
40laryngitis10.4
41intestinal tuberculosis10.4
42allergic bronchopulmonary aspergillosis10.4
43hepatic tuberculosis10.4
44silicosis10.4
45anthracosis10.3
46bronchogenic carcinoma10.2
47lymph node tuberculosis10.2
48retinitis10.2
49oral tuberculosis10.2
50nocardiosis10.2

Graphical network of the top 20 diseases related to Pulmonary Tuberculosis:



Diseases related to pulmonary tuberculosis

Clinical Features for Pulmonary Tuberculosis

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8Disease Ontology
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Symptoms:

8 (show all 8)
  • cough
  • difficulty in breathing
  • inflammatory infiltrations
  • formation of tubercles
  • caseation
  • pleural effusion
  • fibrosis
  • fever

Drugs & Therapeutics for Pulmonary Tuberculosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Tuberculosis

Search NIH Clinical Center for Pulmonary Tuberculosis

Search CenterWatch for Pulmonary Tuberculosis

Genetic Tests for Pulmonary Tuberculosis

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Anatomical Context for Pulmonary Tuberculosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pulmonary Tuberculosis:

32
Lung, T cells, Testes, Monocytes, Lymph node, Skin, Whole blood, Kidney, Heart, Bone, Bone marrow, Liver, Breast, Nk cells, Tongue, Adrenal cortex, Spinal cord, Cortex, Brain

FMA organs/tissues related to Pulmonary Tuberculosis:

14
Lungs

Animal Models for Pulmonary Tuberculosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Tuberculosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0ADA, TLR1, IFNG, IFNGR1, MBL2, HP
2MP:000200610.8IFNGR1, HP, IL10, IL12B, SLC11A1, IFNG
3MP:000539710.7HP, MBL2, IFNGR1, IFNG, CXCL10, IL2RA

Publications for Pulmonary Tuberculosis

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Sources:
50PubMed
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Articles related to Pulmonary Tuberculosis:

(show top 50)    (show all 1202)
idTitleAuthorsYear
1
Active Case Finding of Pulmonary Tuberculosis through Screening of Respiratory Symptomatics Using Sputum Microscopy: Is It Time to Change the Paradigm? (23533747)
2013
2
Paving-stone CT finding in a pulmonary tuberculosis patient. (24273747)
2013
3
Impact and costs of algorithms for the diagnosis of adults with pulmonary tuberculosis in South Africa. (23946950)
2013
4
Scoring systems using chest radiographic features for the diagnosis of pulmonary tuberculosis in adults: a systematic review. (23222871)
2013
5
XpertAr MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. (23440842)
2013
6
Infection rate and tissue localization of murine IL-12p40-producing monocyte-derived CD103(+) lung dendritic cells during pulmonary tuberculosis. (23861965)
2013
7
Prevalence of multidrug resistance in Mycobacterium tuberculosis isolates from HIV seropositive and seronegative patients with pulmonary tuberculosis in north India. (23497169)
2013
8
Randomized clinical trial of thrice-weekly 4-month moxifloxacin or gatifloxacin containing regimens in the treatment of new sputum positive pulmonary tuberculosis patients. (23843980)
2013
9
Frequency of regulatory T-cells in the peripheral blood of patients with pulmonary tuberculosis from shanxi province, china. (23755239)
2013
10
Are we ready to shorten the treatment duration for non-cavitary pulmonary tuberculosis? (23676152)
2013
11
Double-positive Goodpasture's syndrome with concomitant active pulmonary tuberculosis. (23816731)
2013
12
Diagnostic accuracy of XpertAr MTB/RIF on bronchoscopy specimens in patients with suspected pulmonary tuberculosis. (23621953)
2013
13
Assessment of health-related quality of life in patients with pulmonary tuberculosis under programme conditions. (23743314)
2013
14
Statistical Evaluation of Two Microbiological Diagnostic Methods of Pulmonary Tuberculosis After Implementation of a Directly Observed Treatment Short-course Program. (24159529)
2013
15
Drug susceptibility pattern of Mycobacterium tuberculosis isolates from patients of category-II failure of pulmonary tuberculosis under directly observed treatment short-course from north India. (22890158)
2012
16
Performance of frontloading for smear microscopy in the diagnosis of pulmonary tuberculosis: a cross-sectional study at a referral hospital in Uganda. (23144768)
2012
17
Genetic dissection of pulmonary tuberculosis: implications for drug and vaccine development. (22586941)
2012
18
Pulmonary tuberculosis with neuromyelitis optica: an uncommon association of a common disease. (22868021)
2012
19
Altered microRNA signatures in sputum of patients with active pulmonary tuberculosis. (22900099)
2012
20
Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru. (22742941)
2012
21
Variability of infectious aerosols produced during coughing by patients with pulmonary tuberculosis. (22798319)
2012
22
MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms. (22384203)
2012
23
Use of bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative pulmonary tuberculosis. (23131267)
2012
24
The Poor Survival among Pulmonary Tuberculosis Patients in Chiapas, Mexico: The Case of Los Altos Region. (22701170)
2012
25
Altered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection. (23272999)
2012
26
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (19771452)
2010
27
Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts. (20113509)
2010
28
Vitamin D receptor homozygote mutant tt and bb are associated with susceptibility to pulmonary tuberculosis in the Iranian population. (19482503)
2010
29
Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. (18650110)
2009
30
Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis. (19615945)
2009
31
Middle aged male with pulmonary tuberculosis and refractory hypercalcemia at a tertiary care centre in South East Asia: a case report. (19829785)
2009
32
Regulatory role of promoter and 3' UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. (18231846)
2008
33
Reduced erythrocyte CR1 levels in patients with pulmonary tuberculosis is an acquired phenomenon. (18434253)
2008
34
Thoracic actinomycosis in an adolescent mimicking chest wall tumor or pulmonary tuberculosis. (18408935)
2008
35
Rifampin levels, interferon-gamma release and outcome in complicated pulmonary tuberculosis. (17890156)
2007
36
Concurrent pulmonary zygomycosis and Mycobacterium tuberculosis infection: a case report. (17477864)
2007
37
Cytokine profile of t lymphocytes from peripheral blood and bronchoalveolar lavage fluid in patients with active pulmonary tuberculosis. (17309780)
2007
38
Efficiency of chemotherapy of destructive pulmonary tuberculosis, based on the results of rapid detection of drug sensitivity to isoniazid and rifampicin with the "TB-Biochip" test system]. (17002052)
2006
39
Increased specific T cell cytokine responses in patients with active pulmonary tuberculosis from Central Africa. (15908253)
2005
40
Mononeuropathy multiplex and chylothorax as earlier manifestations of pulmonary tuberculosis. (15910561)
2005
41
Interferon-gamma and IgG antibodies to M. tuberculosis in the serum of patients with active pulmonary tuberculosis]. (15751711)
2004
42
Blood protein phenotypes and effectiveness of the treatment of patients with pulmonary tuberculosis]. (10765730)
2000
43
Risk of pulmonary tuberculosis relative to silicosis and exposure to silica dust in South African gold miners. (9816385)
1998
44
Detection of pulmonary and extrapulmonary tuberculosis patients with the 38-kilodalton antigen from Mycobacterium tuberculosis in a rapid membrane-based assay. (8705680)
1996
45
Pulmonary miliary tuberculosis and T-cell abnormalities in a severe combined immunodeficient patient reconstituted with haploidentical bone marrow transplantation. (8086624)
1994
46
Tuberculin-triggered panuveitis in a patient recently treated for active pulmonary tuberculosis. (8250087)
1993
47
Adrenocortical insufficiency in smear positive pulmonary tuberculosis. (1302221)
1992
48
Nocardiosis mimicking pulmonary tuberculosis in Ugandan AIDS patients. (1889302)
1991
49
Ocular toxoplasmosis, trigeminal herpes zoster and pulmonary tuberculosis in a patient with Hodgkin's disease. (1079591)
1975
50
Frozen-shoulder syndrome in patients with pulmonary tuberculosis. (13664720)
1959

Genetic Variations for Pulmonary Tuberculosis

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Expression for genes affiliated with Pulmonary Tuberculosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Tuberculosis

Search GEO for disease gene expression data for Pulmonary Tuberculosis.

Pathways for genes affiliated with Pulmonary Tuberculosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
See all sources

Pathways related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8TLR1, IFNG, IFNGR1, CXCL10, IL10, IL12B
2
Hide members
10.8TLR1, IFNG, IFNGR1, MBL2, DEFA3, IL2RA
310.8TLR1, IFNG, IFNGR1, IL10, IL12B
4
Hide members
10.8IL12B, IL10, IFNGR1, IFNG, TLR1
5
Hide members
10.8IFNG, IFNGR1, CXCL10, IL2RA, IL12B
6
Hide members
10.7IFNG, IFNGR1, IL2RA, IL10, IL12B
710.7IFNG, IFNGR1, IL2RA, IL10, IL12B
8
Hide members
10.7TLR1, CXCL10, IL2RA, IL10, IL12B
9
Hide members
10.7TLR1, IFNG, IFNGR1, IL2RA
10
Hide members
10.7IFNG, IFNGR1, IL10, IL12B
11
Hide members
10.7KIR2DS1, KIR2DS3, IFNGR1, IFNG
12
Immune response Bacterial infections in normal airways
10.6IFNGR1, IFNG, TLR1
1310.6IFNG, IL2RA, IL12B
14
Hide members
10.6IFNG, IL2RA, IL12B
1510.6IFNG, IFNGR1, CXCL10
1610.6IL12B, IL10, IFNG
1710.6IL12B, IL10, IFNG
1810.6IL12B, IL10, IFNG
19
Hide members
10.6IL2RA, CXCL10, IFNGR1
20
Hide members
10.6IL10, IL2RA, IFNG
2110.6IFNGR1, IFNG
22
Hide members
10.6IL12B, IL2RA
2310.5IL12B
24
Hide members
10.5TLR1

Compounds for genes affiliated with Pulmonary Tuberculosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1neopterin4411.3IFNG, MBL2, HP, CXCL10, IL2RA, IL10
2vitamin d4411.3MBL2, HP, CXCL10, IL2RA, IL10, IL12B
3tuberculin4411.3ADA, IL10, IL2RA, HP, MBL2, IFNG
4vegf4411.3IFNG, MBL2, HP, CXCL10, IL2RA, IL10
5ribavirin44 49 1113.3IFNG, MBL2, HP, CXCL10, IL10, ADA
6nitric oxide44 11 2413.3IFNG, MBL2, HP, CXCL10, IL10, IL12B
7cyclosporin a44 28 5913.2IFNG, HLA-S, HP, IL2RA, IL10, ADA
8con a4411.2IFNG, MBL2, HP, IL2RA, IL10
92,5-oligoadenylate4411.2IFNG, CXCL10, IL2RA, IL10, ADA
10il 104411.2IFNG, CXCL10, IL2RA, IL10, IL12B
11imiquimod44 28 59 1114.1TLR1, IFNG, IL10, IL12B
12rantes4411.1IFNG, MBL2, IL2RA, IL12B
13lipoteichoic acid4411.1IL12B, IL10, MBL2, TLR1
14polyinosinic-polycytidylic acid4411.1IFNG, CXCL10, IL10, IL12B
15infliximab44 49 1113.1IFNG, CXCL10, IL2RA, IL10
16histamine44 28 2413.1IFNG, CXCL10, IL2RA, IL10, ADA
17peptidoglycan44 2812.1IL12B, IL10, MBL2, TLR1
18ifn-alpha4411.1IFNG, CXCL10, IL2RA, IL10
19chloroquine44 2 49 28 1115.1HP, CXCL10, IL2RA, IL10
20natalizumab44 1112.0IFNG, IL2RA, IL10
21aspartate4411.0ADA, SLC11A1, MBL2
22il-124411.0IFNG, IL10, IL12B
235 aminosalicylic acid4411.0IL2RA, IL10, IL12B
24polymyxin b4411.0IFNG, MBL2, IL10
25tacrolimus44 49 1113.0IL10, IL2RA, CXCL10, IFNG
26okt34411.0IL10, IL2RA, IFNG
27sulfasalazine44 28 49 1114.0HP, IL2RA, IL12B
28poly(i-c)4411.0IFNG, CXCL10, IL12B
29pentoxifylline44 1112.0IL12B
30mycophenolate mofetil44 49 1113.0IFNG, IL2RA, IL10
31prednisolone44 28 1113.0IL2RA, MBL2
32creatinine4411.0MBL2, HP, CXCL10, IL2RA, ADA
33dexamethasone44 49 28 1113.9ADA
34anti-fungal4410.9IFNG, MBL2, DEFA3
35methotrexate44 49 1112.9ADA, IL10, IL2RA, HLA-S
36cyclophosphamide44 49 1112.9IL2RA, MBL2
37tarc4410.9IFNG, CXCL10, IL10
38ivig4410.9IL10, IL2RA, IFNG
39lactose44 1111.9MBL2, HP, IL2RA
40betaseron4410.9IL10, IFNG
41rolipram44 59 2812.9ADA
42ccl344 2811.9IFNG, CXCL10, IL10
43interferon gamma4410.8IFNG, IL10
44rituximab44 49 1112.8IL10, IL2RA, HP
45sodium stibogluconate44 1111.7IFNG, ADA
46allergens4410.7IFNG, CXCL10, IL10
47theophylline44 28 11 2413.6ADA, IL10, IL2RA
48thalidomide44 49 59 1113.6IL10, IL2RA, IFNG
49pentostatin44 59 28 1113.5IL2RA, ADA
50alpha-galactosylceramide4410.3IL10, IFNG

GO Terms for genes affiliated with Pulmonary Tuberculosis

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16Gene Ontology
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Cellular components related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7ADA, IL2RA, CXCL10, IFNG
2extracellular spaceGO:00561510.6ADA, IFNG, MBL2, DEFA3, HP, CXCL10

Biological processes related to Pulmonary Tuberculosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274211.1MBL2, DEFA3, HP, IL10, SLC11A1, IFNG
2immune responseGO:00695511.0KIR2DS1, TLR1, CXCL10, IL2RA, KIR3DS1
3negative regulation of growth of symbiont in hostGO:04413011.0MBL2, IL10, IL12B, IFNG
4defense response to virusGO:05160711.0IFNG, CXCL10, DEFA3, IL12B
5defense response to protozoanGO:04283210.9IFNG, IL12B, SLC11A1
6cellular response to lipopolysaccharideGO:07122210.9IFNG, IL10, IL12B
7positive regulation of interleukin-6 biosynthetic processGO:04541010.9TLR1, IFNG
8positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
9positive regulation of smooth muscle cell apoptotic processGO:03439310.8IFNG, IL12B
10macrophage activationGO:04211610.8TLR1, SLC11A1
11negative regulation of interleukin-17 productionGO:03270010.8IL12B, IFNG
12inflammatory responseGO:00695410.8SLC11A1, IL10, TLR1, CXCL10
13innate immune responseGO:04508710.7KIR3DS1, DEFA3, TLR1, KIR2DS1, MBL2
14positive regulation of T-helper 1 type immune responseGO:00282710.7SLC11A1, IL12B
15T-helper 1 type immune responseGO:04208810.7TLR1, IL12B
16natural killer cell activationGO:03010110.6IL12B, KIR3DS1
17regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5IFNG, IFNGR1
18positive regulation of osteoclast differentiationGO:04567210.3IFNG, IL12B

Products for genes affiliated with Pulmonary Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet