MCID: PLM022
MIFTS: 37

Pulmonary Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Pulmonary Valve Insufficiency

MalaCards integrated aliases for Pulmonary Valve Insufficiency:

Name: Pulmonary Valve Insufficiency 12 42 14 69
Pulmonary Regurgitation 12 52
Pulmonary Insufficiency Following Trauma and Surgery 12
Pulmonary Incompetence, Non-Rheumatic 12
Pulmonic Valve Regurgitation 12
Pulmonic Insufficiency Nos 12
Pulmonary Incompetence 12
Pulmonary Regurg. 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14265
MeSH 42 D011665
SNOMED-CT 64 91434003
ICD10 33 I37.1
UMLS 69 C0034088

Summaries for Pulmonary Valve Insufficiency

Disease Ontology : 12 A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur.

MalaCards based summary : Pulmonary Valve Insufficiency, also known as pulmonary regurgitation, is related to rheumatic pulmonary valve disease and pleomorphic liposarcoma. An important gene associated with Pulmonary Valve Insufficiency is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Signaling by NODAL and Benzodiazepine Pathway, Pharmacodynamics. The drugs Zinc and Beractant have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes.

Related Diseases for Pulmonary Valve Insufficiency

Diseases in the Pulmonary Valve Disease family:

Pulmonary Valve Insufficiency

Diseases related to Pulmonary Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
id Related Disease Score Top Affiliating Genes
1 rheumatic pulmonary valve disease 10.9
2 pleomorphic liposarcoma 10.4 NKX2-6 NPPB
3 cervical serous adenocarcinoma 10.3 NKX2-6 SLC6A11
4 trophoblastic neoplasm 10.3 NKX2-6 SLC6A11
5 ichthyosis lamellar 2 10.3 NKX2-6 NPPB
6 takayasu arteritis 10.2 GDF1 NKX2-6
7 adams-oliver syndrome 5 10.2 NKX2-6 NPPB
8 optic nerve disease 10.2 GDF1 NKX2-6
9 craniosynostosis 7 10.1 NKX2-6 NPPB
10 ichthyosis 10.1 GDF1 NKX2-6
11 pulmonary valve agenesis-ventricular septal defect-persistent ductus arteriosus syndrome 10.1
12 pulmonary valve agenesis-tetralogy of fallot-absence of ductus arteriosus syndrome 10.1
13 fetal alcohol syndrome 10.1 GDF1 NKX2-6
14 macroglossia 9.9 GDF1 NKX2-6 NPPB
15 artery disease 9.9 GDF1 NKX2-6 NPPB
16 tricho odonto onycho dermal syndrome 9.9 GDF1 NKX2-6 NPPB
17 malignant pineal area germ cell neoplasm 9.9 GDF1 NKX2-6 NPPB
18 tetralogy of fallot 9.9
19 hypothyroidism, congenital nongoitrous, 5 9.9 GDF1 NKX2-6 NPPB
20 surfactant metabolism dysfunction, pulmonary, 2 9.9 GDF1 NKX2-6
21 aneurysm 9.8
22 patent ductus arteriosus 9.7
23 xanthogranulomatous pyelonephritis 9.6 GDF1 NKX2-6 NPPB
24 x-linked sideroblastic anemia with ataxia 9.6 GDF1 LEFTY2
25 congenital diarrhea 7 with exudative enteropathy 9.5 GDF1 LEFTY2 NKX2-6 NPPB
26 ascending cholangitis 7.1 BLVRA GDF1 KIAA0753 LEFTY2 NKX2-6 NPPB

Graphical network of the top 20 diseases related to Pulmonary Valve Insufficiency:



Diseases related to Pulmonary Valve Insufficiency

Symptoms & Phenotypes for Pulmonary Valve Insufficiency

Drugs & Therapeutics for Pulmonary Valve Insufficiency

Drugs for Pulmonary Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 350)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
2 Beractant Approved Phase 4,Phase 3 108778-82-1
3 Poractant alfa Approved Phase 4 129069-19-8
4
Riluzole Approved, Investigational Phase 4,Phase 2,Phase 3 1744-22-5 5070
5
Dexlansoprazole Approved Phase 4 138530-94-6, 103577-45-3 9578005
6
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
7
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
8
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
9
Diclofenac Approved, Vet_approved Phase 4,Early Phase 1 15307-86-5 3033
10
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Acetaminophen Approved Phase 4,Phase 3,Early Phase 1 103-90-2 1983
13
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
14
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
15
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 2078-54-8 4943
16
Menthol Approved Phase 4,Phase 1 2216-51-5 16666
17
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
18
Remifentanil Approved Phase 4,Phase 1 132875-61-7 60815
19
Ropivacaine Approved Phase 4,Early Phase 1 84057-95-4 71273 175805
20
Adenosine Approved, Investigational Phase 4 58-61-7 60961
21
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
22
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
23
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
24
Orphenadrine Approved Phase 4 83-98-7 4601
25
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
26
Ephedrine Approved Phase 4 299-42-3 9294
27
Oxymetazoline Approved Phase 4,Phase 2 1491-59-4 4636
28
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
29
Pseudoephedrine Approved Phase 4 90-82-4 7028
30
Cetirizine Approved Phase 4,Phase 3 83881-51-0 2678
31
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
32
Levocetirizine Approved Phase 4,Phase 3 130018-77-8
33
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
34
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
35
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
36
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
37
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
38
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
39
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
41 Hypoglycemic Agents Phase 4,Phase 3
42 insulin Phase 4,Phase 3
43 Insulin, Globin Zinc Phase 4,Phase 3
44 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
45 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Antacids Phase 4,Phase 2
47 Anti-Ulcer Agents Phase 4,Phase 2
48 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
49 mometasone furoate Phase 4,Phase 3 83919-23-7
50
Proton pump inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 938)

id Name Status NCT ID Phase Drugs
1 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
2 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
3 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
4 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
5 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
6 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
7 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
8 Inspiratory Muscle Training in Hypercapnic COPD Unknown status NCT00291460 Phase 4
9 A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
10 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
11 Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Unknown status NCT00560287 Phase 4
12 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
13 Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation Completed NCT00453726 Phase 4
14 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
15 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
16 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
17 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
18 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
19 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo
20 Supplemental Oxygen and Complications After Abdominal Surgery (The PROXI-trial) Completed NCT00364741 Phase 4 Oxygen
21 Ambulatory Adaptation to Non-Invasive Mechanical Ventilation Completed NCT00698958 Phase 4
22 Effect of Interscalene Block on Ventilatory Function Completed NCT01740453 Phase 4 ropivacaine 2 mg/ml
23 Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients Completed NCT01472302 Phase 4
24 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
25 Non-invasive Ventilation in Terminally Ill Cancer Patients Completed NCT00533143 Phase 4
26 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
27 Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics Completed NCT02363920 Phase 4
28 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4
29 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
30 Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
31 Inhaled Nitric Oxide by Oxygen Hood in Neonates Completed NCT00732537 Phase 4 inhaled Nitric Oxide;Oxygen (>90% by hood) - standard therapy
32 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
33 Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain Completed NCT02445599 Phase 4 Diclofenac;Midazolam;Atropine;bucain + fentanyl;Nalbuphine;Diclofenac;Metamizole-sodium;Tramadol
34 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
35 Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
36 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients Completed NCT00355732 Phase 4
37 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
38 Helmet Ventilation in Acute Hypercapnic Respiratory Failure Completed NCT01645358 Phase 4
39 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4
40 Treatment of High Altitude Polycythemia by Acetazolamide Completed NCT00424970 Phase 4 acetazolamide
41 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
42 Effectiveness of Oxymetazoline Added on Nasal Steroid in Rhinitis With Persistent Nasal Obstruction Completed NCT01847131 Phase 4 oxymetazoline;Placebo nasal spray
43 Effects of Slow Breathing on Blood Pressure and Autonomic Function Completed NCT01390727 Phase 4
44 The Effect of Packing in Post Operative Management of FESS Completed NCT00793117 Phase 4
45 Levocetirizine in the Treatment of Nasal Obstruction Due to Perennial Allergic Rhinitis Completed NCT00439712 Phase 4 Levocetirizine;Placebo
46 Sugammadex vs. Placebo to Prevent Residual Neuromuscular Block in the Post--‐Anesthesia Care Unit Recruiting NCT02822001 Phase 4 Sugammadex;Placebo
47 TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia Recruiting NCT03282669 Phase 4 Intrathecal Morphine;Intravenous hydromorphone
48 Handling Oxygenation Targets in the Intensive Care Unit Recruiting NCT03174002 Phase 4 Oxygen;Oxygen
49 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine
50 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4

Search NIH Clinical Center for Pulmonary Valve Insufficiency

Cochrane evidence based reviews: pulmonary valve insufficiency

Genetic Tests for Pulmonary Valve Insufficiency

Anatomical Context for Pulmonary Valve Insufficiency

MalaCards organs/tissues related to Pulmonary Valve Insufficiency:

39
Lung, Heart, Testes, Brain, Liver, Spinal Cord, Bone

Publications for Pulmonary Valve Insufficiency

Articles related to Pulmonary Valve Insufficiency:

(show all 12)
id Title Authors Year
1
Pulmonary Valve Repair for Patients With Acquired Pulmonary Valve Insufficiency. ( 27083251 )
2016
2
Case 2/2009: eight-year-old child with pulmonary valve insufficiency and left pulmonary artery stenosis, as residual defects after tetralogy of fallot repair. ( 19360250 )
2009
3
Relief of branch pulmonary artery stenosis reduces pulmonary valve insufficiency in a swine model. ( 19619782 )
2009
4
Chronic pulmonary valve insufficiency after repaired tetralogy of Fallot: diagnostics, reoperations and reconstruction possibilities. ( 17338667 )
2007
5
Massive pulmonary valve insufficiency associated with double pulmonary artery and ascending aorta aneurysm. ( 16480029 )
2006
6
Idiopathic right pulmonary artery aneurysm with pulmonary valve insufficiency. ( 8808073 )
1996
7
Pulmonary valve insufficiency: malignant or benign? ( 1607521 )
1992
8
Repair of pulmonary valve insufficiency using an autologous monocusp. ( 3778011 )
1986
9
Diagnosis of tricuspid and pulmonary valve insufficiency by cinecardioangiography. ( 5055594 )
1972
10
Pulmonary valve insufficiency in a case of tetralogy of Fallot after Brock's operation: correction by heterologous aortic graft. ( 5166614 )
1971
11
Patent ductus arteriosus and pulmonary valve insufficiency; unusual clinical manifestations. ( 5509638 )
1970
12
Clinical recognition of congenital pulmonary valve insufficiency. ( 6058370 )
1967

Variations for Pulmonary Valve Insufficiency

Expression for Pulmonary Valve Insufficiency

Search GEO for disease gene expression data for Pulmonary Valve Insufficiency.

Pathways for Pulmonary Valve Insufficiency

Pathways related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.65 GDF1 LEFTY2
2
Show member pathways
9.88 SLC6A1 SLC6A11

GO Terms for Pulmonary Valve Insufficiency

Biological processes related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.43 GDF1 LEFTY2
2 SMAD protein signal transduction GO:0060395 9.37 GDF1 LEFTY2
3 cell development GO:0048468 9.32 GDF1 LEFTY2
4 regulation of MAPK cascade GO:0043408 9.26 GDF1 LEFTY2
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.16 GDF1 LEFTY2
6 response to calcium ion GO:0051592 9.1 SLC6A1
7 neurotransmitter transport GO:0006836 8.96 SLC6A1 SLC6A11
8 gamma-aminobutyric acid transport GO:0015812 8.62 SLC6A1 SLC6A11

Molecular functions related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.16 GDF1 LEFTY2
2 neurotransmitter:sodium symporter activity GO:0005328 8.96 SLC6A1 SLC6A11
3 gamma-aminobutyric acid:sodium symporter activity GO:0005332 8.62 SLC6A1 SLC6A11

Sources for Pulmonary Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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