MCID: PLM041
MIFTS: 43

Pulmonary Valve Stenosis malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Pulmonary Valve Stenosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pulmonary valve stenosis is a heart valve disorder in which outflow of blood from the right ventricle of... more...

MalaCards: Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to aortic valve stenosis and ventricular septal defect. An important gene associated with Pulmonary Valve Stenosis is JAG1 (jagged 1), and among its related pathways are TSLP Signaling Pathway and Signaling events regulated by Ret tyrosine kinase. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are craniofacial and integument.

Aliases & Classifications for Pulmonary Valve Stenosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pulmonary valve stenosis 8 42 10 44 60
valvular pulmonary stenosis 42 48
pulmonary stenosis, cause unspecified 8
heart valve pulmonary stenosis 42
valvate pulmonary stenosis 42
valvar pulmonary stenosis 42
pulmonic valve stenosis 8
pulmonary stenosis nos 8
pulmonic stenosis nos 8


External Ids:

Disease Ontology8 DOID:6420
MeSH34 D011666
MESH via Orphanet35 D011666
ICD10 via Orphanet26 Q22.1
SNOMED-CT56 56786000
SNOMED-CT via Orphanet57 56786000
UMLS via Orphanet61 C0034089
ICD1025 I37.0, I37.2

Related Diseases for Pulmonary Valve Stenosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pulmonary Valve Stenosis family:

Congenital Pulmonary Valve Stenosis

Diseases related to Pulmonary Valve Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1aortic valve stenosis30.9PDLIM1, ELN
2ventricular septal defect30.6SLC35B2, CLTCL1
3tetralogy of fallot30.6CLTCL1, HIRA, JAG1
4hypertrophic cardiomyopathy30.3PTPN11
5congenital heart defect30.1PTPN11, JAG1
6noonan syndrome30.1PTPN11, MAP2K2, SOS1
7congenital pulmonary valve stenosis10.5
8coronary stenosis10.4
9double outlet right ventricle10.3
10mitral valve stenosis10.3
11tricuspid valve stenosis10.3
12hypoplastic left heart syndrome10.3
13endocarditis10.3
14infective endocarditis10.2
15patent foramen ovale10.1
16pulmonary edema10.1
17ataxia telangiectasia10.1
18cerebritis10.1
19tricuspid valve insufficiency10.1
20malignant hyperthermia10.1
21pulmonary valve insufficiency10.1
22patent ductus arteriosus10.1
23congestive heart failure10.1
24muscular dystrophy10.1
25pulmonary embolism10.1
26pulmonary valve disease10.1
27sarcoma10.1
2818p deletion syndrome10.1
29hemophilia10.1
30williams syndrome10.1
31pulmonary supravalvular stenosis10.1
32pulmonic stenosis10.1
33myeloid leukemia10.0PTPN11
34glioblastoma multiforme10.0PTPN11
35leukemia10.0PTPN11
36cardiofaciocutaneous syndrome10.0MAP2K2
37mitral valve prolapse10.0PDLIM1
38velocardiofacial syndrome10.0HIRA
39juvenile myelomonocytic leukemia10.0PTPN11
40leopard syndrome10.0SOS1, PTPN11
41adenocarcinoma10.0ELN
42supravalvular aortic stenosis10.0ELN, PDLIM1
43short stature10.0SOS1, MAP2K2, PTPN11
44developmental disabilities10.0JAG1, HIRA, PTPN11, ELN
45costello syndrome10.0SOS1, MAP2K2, PTPN11, ELN

Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to pulmonary valve stenosis

Clinical Features for Pulmonary Valve Stenosis

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Drugs & Therapeutics for Pulmonary Valve Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Valve Stenosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Valve Stenosis

Search NIH Clinical Center for Pulmonary Valve Stenosis

Search CenterWatch for Pulmonary Valve Stenosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pulmonary Valve Stenosis

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Anatomical Context for Pulmonary Valve Stenosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pulmonary Valve Stenosis:

32
Heart, Lung

Animal Models for Pulmonary Valve Stenosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5SOS1, JAG1, MAP2K2, HIRA, PTPN11
2MP:00107718.3PTPN11, MAP2K2, JAG1, SOS1, COL5A3
3MP:00053697.9COL5A3, SOS1, JAG1, PTPN11, ELN
4MP:00053767.0ELN, COL5A3, PVR, SOS1, JAG1, MAP2K2

Publications for Pulmonary Valve Stenosis

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Sources:
50PubMed
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Articles related to Pulmonary Valve Stenosis:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Assessment of the vortex flow in the post-stenotic dilatation above the pulmonary valve stenosis in an infant using echocardiography vector flow mapping. (24135837)
2013
2
Congenital heart defects in recurrent reciprocal 1q21.1 deletion and duplication syndromes: rare association with pulmonary valve stenosis. (23270675)
2013
3
The Comparison between the Echocardiographic Data to the Cardiac Catheterization Data on the Diagnosis, Treatment, and Follow-Up in Patients Diagnosed as Pulmonary Valve Stenosis. (23560138)
2013
4
Immediate, short, intermediate and long-term results of balloon valvuloplasty in congenital pulmonary valve stenosis. (23737317)
2013
5
Severe aortic or pulmonary valve stenosis in premature infants. (22464565)
2012
6
Successful pulmonary valvuloplasty in combined pulmonary valve stenosis and selective left pulmonary artery ectasia. (22037711)
2011
7
Case 4/2011 - 49-year-old man with pulmonary valve stenosis and atrial septal defect as residual lesions after correction of tetralogy of Fallot, which occurred 30 years ago. (21894391)
2011
8
Combined pulmonary and aortic valve stenosis--prenatal diagnosis and postnatal interventional therapy. (19439992)
2009
9
Histological study of right ventricle-pulmonary artery valved conduit implantation (RPVC) in dogs with pulmonic stenosis. (19420842)
2009
10
Cardiovascular effects of right ventricle-pulmonary artery valved conduit implantation in experimental pulmonic stenosis. (19420852)
2009
11
Patent ductus arteriosus and pulmonary valve stenosis in a patient with 18p deletion syndrome. (18581602)
2008
12
Successful percutaneous balloon valvuloplasty in a preterm infant weighing 1500 g with critical pulmonary valve stenosis. (18711615)
2008
13
Response to: "Echocardiographic assessment of isolated pulmonary valve stenosis: which outpatient doppler gradient has the most clinical validity?". (16500506)
2006
14
Total percutaneous correction of a tetralogy of Fallot variant with dominant pulmonary valve stenosis. (15710716)
2005
15
Echocardiographic assessment of isolated pulmonary valve stenosis: which outpatient Doppler gradient has the most clinical validity? (16275521)
2005
16
Significant aortic and pulmonary valve stenosis in the prenatal period: diagnosis, treatment and outcome. A two-centre study. (15139701)
2004
17
Short- and intermediate-term follow-up results of percutaneous transluminal balloon valvuloplasty in adolescents and young adults with congenital pulmonary valve stenosis. (12947206)
2003
18
Nonsyndromic pulmonary valve stenosis and the PTPN11 gene. (12522798)
2003
19
Severe pulmonary hypertension in patients with severe aortic valve stenosis: clinical profile and prognostic implications. (12204512)
2002
20
Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis. (9732908)
1998
21
Use of a cerebral angiographic catheter facilitates crossing the pulmonary valve in neonates with critical or severe pulmonary valve stenosis. (9359566)
1997
22
Natural course of isolated pulmonary valve stenosis in infants and children utilizing Doppler echocardiography. (9036756)
1997
23
Balloon pulmonary valvuloplasty for pulmonary valve stenosis with atrial septal defect. (9070577)
1997
24
Effects of balloon pulmonary valvuloplasty on atrial shunting--a patient with pulmonary valve stenosis and a large secundum atrial septal defect. (9070976)
1997
25
Concurrent balloon dilatation of coexisting congenital pulmonary and aortic valve stenosis. (8682561)
1996
26
Partial anomalous pulmonary venous drainage associated with intact atrial septum and pulmonary valve stenosis. (9000813)
1996
27
Acute effects of balloon valvuloplasty and pacing on left ventricular performance in children with moderate pulmonary valve stenosis, analysed by systolic and diastolic pressure-volume relationships. (8174588)
1994
28
Critical pulmonary valve stenosis in the neonate: a technique to facilitate balloon dilation. (8296766)
1994
29
Comparison of risks and short- and long-term results of balloon dilatation versus surgical treatment for pulmonary and aortic valve stenosis and restenosis and coarctation and recoarctation of the aorta. (8287086)
1993
30
Percutaneous closure of a secundum atrial septal defect and double balloon valvotomies of a severe mitral and aortic valve stenosis in a patient with Lutembacher's syndrome and severe pulmonary hypertension. (1373992)
1992
31
Success determining factors in percutaneous transluminal balloon valvuloplasty of pulmonary valve stenosis. (2009887)
1991
32
Percutaneous balloon pulmonic valvuloplasty following treated endocarditis in a patient with congenital pulmonary valve stenosis. (2276195)
1990
33
Variability of the Doppler gradient in pulmonary valve stenosis before and after balloon dilatation. (2789913)
1989
34
Percutaneous transluminal balloon valvuloplasty of congenital pulmonary valve stenosis, with a special report on infants and neonates. (3351148)
1988
35
Percutaneous balloon valvuloplasty for pulmonary valve stenosis using single or double balloon technique. (3249009)
1988
36
Percutaneous transluminal balloon valvuloplasty in congenital pulmonary valve stenosis. (15227347)
1986
37
Premature closure of the foramen ovale and congenital pulmonary cystic lymphangiectasis in aortic valve atresia or in severe aortic valve stenosis. (3953463)
1986
38
Cyanosis after surgical correction of pulmonary valve stenosis: an old problem revisited. (15227016)
1985
39
Percutaneous balloon valvuloplasty for pulmonary valve stenosis in infants and children. (2932133)
1985
40
Relief of pulmonary valve stenosis in first week of life by percutaneous balloon valvuloplasty. (6143008)
1984
41
Surgical approach to critical pulmonary valve stenosis in infants less than six months of age. (6827845)
1983
42
Myxoma of the pulmonary valve causing severe pulmonic stenosis in infancy. (7087523)
1982
43
"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency. (519671)
1979
44
Lung hypoplasia in congenital pulmonary valve stenosis. (902390)
1977
45
'Isolated' pulmonary valve stenosis as part of more widespread cardiovascular disease. (944584)
1976
46
Selection of patients for surgical correction of ventricular septal defect, congenital aortic valve stenosis, and pulmonary valve stenosis. (4415708)
1974
47
Congenital pulmonary valve stenosis with intact ventricular septum and interatrial communication. (4649870)
1972
48
Pulmonary valve stenosis. (5448660)
1970
49
Combined mitral and pulmonary valve stenosis. (5904222)
1966
50
Pure pulmonary valve stenosis. (14434567)
1959

Genetic Variations for Pulmonary Valve Stenosis

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Expression for genes affiliated with Pulmonary Valve Stenosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Valve Stenosis

Search GEO for disease gene expression data for Pulmonary Valve Stenosis.

Pathways for genes affiliated with Pulmonary Valve Stenosis

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PTPN11, MAP2K2
29.8PTPN11, SOS1
3
Hide members
9.8PTPN11, SOS1
49.8PTPN11, SOS1
59.8SOS1, PTPN11
6
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.8SOS1, PTPN11
79.8SOS1, PTPN11
89.8SOS1, PTPN11
99.8SOS1, PTPN11
109.8SOS1, PTPN11
119.8PTPN11, SOS1
12
Hide members
9.7SOS1, MAP2K2
13
Hide members
9.7SOS1, MAP2K2
14
Hide members
9.7MAP2K2, SOS1
15
Hide members
9.7MAP2K2, SOS1
16
Hide members
9.7MAP2K2, SOS1
17
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.4SOS1, MAP2K2, PTPN11
189.4SOS1, MAP2K2, PTPN11
199.4SOS1, MAP2K2, PTPN11
20
Development Prolactin receptor signaling
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9.4SOS1, MAP2K2, PTPN11
21
Development FGF-family signaling
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9.4SOS1, MAP2K2, PTPN11
229.4SOS1, MAP2K2, PTPN11
23
Hide members
9.4SOS1, MAP2K2, PTPN11
24
Hide members
9.4SOS1, MAP2K2, PTPN11
259.4PTPN11, MAP2K2, SOS1
26
Hide members
9.4PTPN11, MAP2K2, SOS1
27
Translation Insulin regulation of translation
Hide members
9.4PTPN11, MAP2K2, SOS1
289.4PTPN11, MAP2K2, SOS1
299.4PTPN11, MAP2K2, SOS1
309.4PTPN11, MAP2K2, SOS1
31
Hide members
9.4PTPN11, MAP2K2, SOS1
329.4PTPN11, MAP2K2, SOS1
33
Hide members
9.4PTPN11, MAP2K2, SOS1
34
Hide members
9.4PTPN11, MAP2K2, SOS1
35
Immune response IL-2 activation and signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
36
Development EPO-induced Jak-STAT pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
37
Hide members
9.4PTPN11, MAP2K2, SOS1
38
Hide members
9.4PTPN11, MAP2K2, SOS1
39
Immune response IL-6 signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
40
Hide members
9.4PTPN11, MAP2K2, SOS1
41
Hide members
9.4PTPN11, MAP2K2, SOS1
42
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.4PTPN11, MAP2K2, SOS1
43
Hide members
9.4PTPN11, MAP2K2, SOS1
449.4PTPN11, MAP2K2, SOS1
459.0JAG1, MAP2K2, SLC35B2, PTPN11
46
Hide members
8.9COL5A3, SOS1, MAP2K2
47
Hide members
8.9COL5A3, SOS1, MAP2K2
48
Hide members
8.9COL5A3, SOS1, MAP2K2
49
Hide members
8.6COL5A3, SOS1, MAP2K2, PTPN11
50
Hide members
8.4ELN, MAP2K2, SOS1, COL5A3

Compounds for genes affiliated with Pulmonary Valve Stenosis

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GO Terms for genes affiliated with Pulmonary Valve Stenosis

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16Gene Ontology
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Biological processes related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:0082869.5PTPN11, MAP2K2, SOS1
2fibroblast growth factor receptor signaling pathwayGO:0085439.4SOS1, MAP2K2, PTPN11
3neurotrophin TRK receptor signaling pathwayGO:0480119.4PTPN11, MAP2K2, SOS1
4Fc-epsilon receptor signaling pathwayGO:0380959.3PTPN11, MAP2K2, SOS1
5epidermal growth factor receptor signaling pathwayGO:0071739.1SOS1, MAP2K2, PTPN11
6axon guidanceGO:0074118.7PTPN11, MAP2K2, SOS1, COL5A3

Products for genes affiliated with Pulmonary Valve Stenosis

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  • Antibodies
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Sources for Pulmonary Valve Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet