MCID: PLM041
MIFTS: 37

Pulmonary Valve Stenosis malady

Cardiovascular, Fetal categories

Summaries for Pulmonary Valve Stenosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pulmonary valve stenosis is a heart valve disorder in which outflow of blood from the right ventricle of... more...

MalaCards: Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to aortic valve stenosis and ventricular septal defect. An important gene associated with Pulmonary Valve Stenosis is JAG1 (jagged 1), and among its related pathways are TSLP Signaling Pathway and Signaling events regulated by Ret tyrosine kinase. The drug alprostadil has been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and integument.

Aliases & Classifications for Pulmonary Valve Stenosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Cardiovascular


Aliases & Descriptions:

pulmonary valve stenosis 8 43 10 45 61
valvular pulmonary stenosis 43 49
pulmonary stenosis, cause unspecified 8
heart valve pulmonary stenosis 43
valvate pulmonary stenosis 43
valvar pulmonary stenosis 43
pulmonic valve stenosis 8
pulmonary stenosis nos 8
pulmonic stenosis nos 8


External Ids:

Disease Ontology8 DOID:6420
MeSH35 D011666
MESH via Orphanet36 D011666
ICD10 via Orphanet26 Q22.1
SNOMED-CT57 56786000
SNOMED-CT via Orphanet58 56786000
UMLS via Orphanet62 C0034089
ICD1025 I37.0, I37.2

Related Diseases for Pulmonary Valve Stenosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pulmonary Valve Stenosis family:

congenital pulmonary valve stenosis

Diseases related to Pulmonary Valve Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1aortic valve stenosis30.9PDLIM1, ELN
2ventricular septal defect30.7SLC35B2, CLTCL1
3hypertrophic cardiomyopathy30.4PTPN11
4noonan syndrome30.1PTPN11, MAP2K2, SOS1
5congenital pulmonary valve stenosis10.8
6mitral valve stenosis10.3
7tricuspid valve stenosis10.3
8hypoplastic left heart syndrome10.3
9n syndrome10.3
10pulmonic stenosis10.3
11patent foramen ovale10.1
12pulmonary edema10.1
13ataxia telangiectasia10.1
14tricuspid valve insufficiency10.1
15malignant hyperthermia10.1
16pulmonary valve insufficiency10.1
17patent ductus arteriosus10.1
18hemophilia10.1
19williams syndrome10.1
20prune belly syndrome10.1
21aortic arch interruption10.1
22aortic coarctation10.1
23tricuspid atresia10.1
24pulmonary vein stenosis10.1
251q21.1 deletion10.1
26ataxia10.1
27pulmonary function10.1
28atrial septal defect 210.1
29congenital tricuspid stenosis10.1
30coronary sinus stenosis10.1
31myeloid leukemia10.0PTPN11
32glioblastoma multiforme10.0PTPN11
33leukemia10.0PTPN11
34cardiofaciocutaneous syndrome10.0MAP2K2
35congenital heart defect10.0PTPN11, JAG1
36mitral valve prolapse10.0PDLIM1
37velocardiofacial syndrome10.0HIRA
38juvenile myelomonocytic leukemia10.0PTPN11
39leopard syndrome10.0SOS1, PTPN11
40adenocarcinoma10.0ELN
41tetralogy of fallot10.0CLTCL1, HIRA, JAG1
42supravalvular aortic stenosis10.0ELN, PDLIM1
43short stature10.0SOS1, MAP2K2, PTPN11
44developmental disabilities10.0JAG1, HIRA, PTPN11, ELN
45costello syndrome10.0SOS1, MAP2K2, PTPN11, ELN

Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to pulmonary valve stenosis

Clinical Features for Pulmonary Valve Stenosis

Drugs & Therapeutics for Pulmonary Valve Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Valve Stenosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Valve Stenosis

Search NIH Clinical Center for Pulmonary Valve Stenosis

Search CenterWatch for Pulmonary Valve Stenosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pulmonary Valve Stenosis

Anatomical Context for Pulmonary Valve Stenosis

Animal Models for Pulmonary Valve Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5PTPN11, SOS1, JAG1, MAP2K2, HIRA
2MP:00107718.3COL5A3, JAG1, MAP2K2, PTPN11, SOS1
3MP:00053697.9SOS1, JAG1, PTPN11, ELN, COL5A3
4MP:00053767.0PVR, COL5A3, SOS1, JAG1, ELN, PTPN11

Publications for Pulmonary Valve Stenosis

Sources:
51PubMed
See all sources

Articles related to Pulmonary Valve Stenosis:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Percutaneous transluminal pulmonary valvuloplasty in a child with tricuspid atresia, ventricular septal defect, and severe pulmonary valve stenosis: Usefulness of the Femoral Artery Approach. (24030841)
2013
2
Long-term Results of Balloon Pulmonary Valvuloplasty in Children with Congenital Pulmonary Valve Stenosis. (23550107)
2013
3
Transjugular Balloon Pulmonary Valvuloplasty Through a Bidirectional Glenn Shunt for Dysplastic Pulmonary Valve Stenosis in an 8.7-Year-Old Boy with Inaccessible Femoral Veins. (24103403)
2013
4
Impact of pulmonary hypertension on mortality after operation for isolated aortic valve stenosis. (23714589)
2013
5
Immediate, short, intermediate and long-term results of balloon valvuloplasty in congenital pulmonary valve stenosis. (23737317)
2013
6
Pulmonary valve stenosis causing massive pulmonary artery aneurysm: a conservative approach. (20442668)
2012
7
"Vanishing" pulmonary valve stenosis. (22529602)
2012
8
Percutaneous balloon valvuloplasty inpatients with pulmonary valve stenosis: a single center experiment. (22768462)
2012
9
Long-term outcome after treatment of isolated pulmonary valve stenosis. (21078529)
2012
10
Impact of pulmonary hypertension on outcomes after aortic valve replacement for aortic valve stenosis. (21596173)
2011
11
Acute pulmonary reperfusion hemorrhage: a rare complication after oversized percutaneous balloon valvuloplasty for pulmonary valve stenosis. (19948440)
2009
12
Histological study of right ventricle-pulmonary artery valved conduit implantation (RPVC) in dogs with pulmonic stenosis. (19420842)
2009
13
Effects of balloon valvuloplasty on coronary blood flow in neonates with critical pulmonary valve stenosis assessed with transthoracic Doppler echocardiography. (19101111)
2009
14
Cardiovascular effects of right ventricle-pulmonary artery valved conduit implantation in experimental pulmonic stenosis. (19420852)
2009
15
'Parachute' accessory mitral leaflet and pulmonary valve stenosis in an asymptomatic 85-year-old man. (17827197)
2008
16
Aortic valve replacement improves survival in severe aortic stenosis associated with severe pulmonary hypertension. (17588389)
2007
17
Long-term follow-up of patients after surgical treatment for isolated pulmonary valve stenosis. (16007892)
2005
18
Total percutaneous correction of a tetralogy of Fallot variant with dominant pulmonary valve stenosis. (15710716)
2005
19
Short- and intermediate-term follow-up results of percutaneous transluminal balloon valvuloplasty in adolescents and young adults with congenital pulmonary valve stenosis. (12947206)
2003
20
Initial and late results after catheter intervention for neonatal critical pulmonary valve stenosis and atresia with intact ventricular septum: a technique in continual evolution. (12112896)
2002
21
Balloon valvuloplasty for critical pulmonary valve stenosis in a premature infant. (11894160)
2001
22
Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis: diagnosis by polymerase chain reaction. (11112222)
2000
23
Balloon valvuloplasty of critical pulmonary valve stenosis in a premature neonate. (9986894)
1999
24
Right ventricular myocardial sinusoidal-coronary artery connections in critical pulmonary valve stenosis. (9568230)
1998
25
Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis. (9732908)
1998
26
Effectiveness of an umbilical artery "snare assisted" approach for critical pulmonary valve stenosis or atresia in the neonate. (9399736)
1997
27
Partial anomalous pulmonary venous drainage associated with intact atrial septum and pulmonary valve stenosis. (9000813)
1996
28
Percutaneous transluminal balloon pulmonary valvuloplasty using domestic balloon catheter for congenital pulmonary valve stenosis in children. (9206063)
1996
29
Syndrome of combined aortic and pulmonary valve stenosis: successful treatment with balloon dilatation. (8197996)
1994
30
Comparison of risks and short- and long-term results of balloon dilatation versus surgical treatment for pulmonary and aortic valve stenosis and restenosis and coarctation and recoarctation of the aorta. (8287086)
1993
31
Intermediate-term results of balloon valvuloplasty for isolated and complicated pulmonary valve stenosis. (1625356)
1992
32
Success determining factors in percutaneous transluminal balloon valvuloplasty of pulmonary valve stenosis. (2009887)
1991
33
Balloon valvotomy of calcified pulmonary valve stenosis. (2354477)
1990
34
Percutaneous transluminal balloon valvuloplasty of congenital pulmonary valve stenosis, with a special report on infants and neonates. (3351148)
1988
35
Results of balloon valvuloplasty in typical and dysplastic pulmonary valve stenosis: Doppler echocardiographic follow-up. (3392342)
1988
36
Regression of pulmonary valve stenosis due to a dysplastic valve presenting in the neonatal period. (3229433)
1988
37
Pulmonary valve stenosis associated with hypertrophic cardiomyopathy. (3432109)
1987
38
Negative right ventricular diastolic pressure after operation for pulmonary valve stenosis: the phenomenon and its relation to volume load and conal contraction. (3947487)
1986
39
Coarctation of the aorta associated with pulmonary valve stenosis. (3957471)
1986
40
Noninvasive assessment of pulmonary valve stenosis, aortic valve stenosis and coarctation of the aorta in critically ill neonates. (3946241)
1986
41
Pulmonary valve stenosis and hemophilia A. Report of three cases and discussion of a possible genetic linkage. (3778055)
1986
42
Familial pulmonary valve stenosis, atrial septal defect, and unique electrocardiogram abnormalities. (4045962)
1985
43
Relief of pulmonary valve stenosis in first week of life by percutaneous balloon valvuloplasty. (6143008)
1984
44
Severe congestive heart failure in mild pulmonic stenosis due to dysplastic pulmonary valve associated with cardiomyopathy. (6224694)
1983
45
Critical pulmonary valve stenosis with intact ventricular septum. (462464)
1979
46
'Isolated' pulmonary valve stenosis as part of more widespread cardiovascular disease. (944584)
1976
47
Congenital pulmonary valve stenosis with intact ventricular septum and interatrial communication. (4649870)
1972
48
Isolated pulmonary valve stenosis. A follow-up study. (5113786)
1971
49
Combined mitral and pulmonary valve stenosis. (5904222)
1966
50
Pulmonary valve stenosis without ventricular septal defect: results of surgery. (5935844)
1966

Genetic Variations for Pulmonary Valve Stenosis

Expression for genes affiliated with Pulmonary Valve Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Valve Stenosis

Search GEO for disease gene expression data for Pulmonary Valve Stenosis.

Pathways for genes affiliated with Pulmonary Valve Stenosis

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PTPN11, MAP2K2
29.8PTPN11, SOS1
3
Hide members
9.8PTPN11, SOS1
49.8PTPN11, SOS1
59.8SOS1, PTPN11
6
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.8SOS1, PTPN11
79.8SOS1, PTPN11
89.8SOS1, PTPN11
99.8SOS1, PTPN11
109.8SOS1, PTPN11
119.8PTPN11, SOS1
12
Hide members
9.7SOS1, MAP2K2
13
Hide members
9.7SOS1, MAP2K2
14
Hide members
9.7MAP2K2, SOS1
15
Hide members
9.7MAP2K2, SOS1
16
Hide members
9.7MAP2K2, SOS1
17
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.4SOS1, MAP2K2, PTPN11
189.4SOS1, MAP2K2, PTPN11
199.4SOS1, MAP2K2, PTPN11
20
Development Prolactin receptor signaling
Hide members
9.4SOS1, MAP2K2, PTPN11
21
Development FGF-family signaling
Hide members
9.4SOS1, MAP2K2, PTPN11
229.4SOS1, MAP2K2, PTPN11
23
Hide members
9.4SOS1, MAP2K2, PTPN11
24
Hide members
9.4SOS1, MAP2K2, PTPN11
259.4PTPN11, MAP2K2, SOS1
26
Hide members
9.4PTPN11, MAP2K2, SOS1
27
Translation Insulin regulation of translation
Hide members
9.4PTPN11, MAP2K2, SOS1
289.4PTPN11, MAP2K2, SOS1
299.4PTPN11, MAP2K2, SOS1
309.4PTPN11, MAP2K2, SOS1
31
Hide members
9.4PTPN11, MAP2K2, SOS1
329.4PTPN11, MAP2K2, SOS1
33
Hide members
9.4PTPN11, MAP2K2, SOS1
34
Hide members
9.4PTPN11, MAP2K2, SOS1
35
Immune response IL-2 activation and signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
36
Development EPO-induced Jak-STAT pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
37
Hide members
9.4PTPN11, MAP2K2, SOS1
38
Hide members
9.4PTPN11, MAP2K2, SOS1
39
Immune response IL-6 signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
40
Hide members
9.4PTPN11, MAP2K2, SOS1
41
Hide members
9.4PTPN11, MAP2K2, SOS1
42
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.4PTPN11, MAP2K2, SOS1
43
Hide members
9.4PTPN11, MAP2K2, SOS1
449.4PTPN11, MAP2K2, SOS1
459.0JAG1, MAP2K2, SLC35B2, PTPN11
46
Hide members
8.9COL5A3, SOS1, MAP2K2
47
Hide members
8.9COL5A3, SOS1, MAP2K2
48
Hide members
8.9COL5A3, SOS1, MAP2K2
49
Hide members
8.6COL5A3, SOS1, MAP2K2, PTPN11
50
Hide members
8.4ELN, MAP2K2, SOS1, COL5A3

Compounds for genes affiliated with Pulmonary Valve Stenosis

GO Terms for genes affiliated with Pulmonary Valve Stenosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:0082869.5MAP2K2, PTPN11, SOS1
2fibroblast growth factor receptor signaling pathwayGO:0085439.4PTPN11, MAP2K2, SOS1
3neurotrophin TRK receptor signaling pathwayGO:0480119.4PTPN11, MAP2K2, SOS1
4Fc-epsilon receptor signaling pathwayGO:0380959.3MAP2K2, SOS1, PTPN11
5epidermal growth factor receptor signaling pathwayGO:0071739.1PTPN11, SOS1, MAP2K2
6axon guidanceGO:0074118.7COL5A3, PTPN11, MAP2K2, SOS1

Products for genes affiliated with Pulmonary Valve Stenosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Valve Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet