MCID: PLM041
MIFTS: 47

Pulmonary Valve Stenosis malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Pulmonary Valve Stenosis

Aliases & Descriptions for Pulmonary Valve Stenosis:

Name: Pulmonary Valve Stenosis 12 50 29 52 42 14 69
Valvular Pulmonary Stenosis 50 56
Heart Valve Pulmonary Stenosis 50
Valvate Pulmonary Stenosis 50
Valvar Pulmonary Stenosis 50
Pulmonary Stenosis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6420
MeSH 42 D011666
SNOMED-CT 64 56786000
Orphanet 56 ORPHA99054
MESH via Orphanet 43 D011666
ICD10 via Orphanet 34 Q22.1
UMLS via Orphanet 70 C0034089
ICD10 33 I37.0 I37.2
UMLS 69 C0034089

Summaries for Pulmonary Valve Stenosis

MalaCards based summary : Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to pulmonic stenosis and noonan syndrome 1. An important gene associated with Pulmonary Valve Stenosis is PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11), and among its related pathways/superpathways are Negative regulation of FGFR1 signaling and Signaling by FGFR2. The drugs Tadalafil and Dobutamine have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related phenotypes are cardiovascular system and embryo

Wikipedia : 71 Pulmonary valve stenosis (PVS) is a heart valve disorder in which outflow of blood from the right... more...

Related Diseases for Pulmonary Valve Stenosis

Diseases related to Pulmonary Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 pulmonic stenosis 11.5
2 noonan syndrome 1 11.0
3 pseudomonas stutzeri infections 10.1 PTPN11 SOS1
4 rdh12-related leber congenital amaurosis 10.1 PTPN11 SOS1
5 syndactyly-polydactyly-earlobe syndrome 10.1 JAG1 PTPN11
6 thyroid hormone metabolism, abnormal 10.1 JAG1 PTPN11
7 nephrolithiasis 10.1 PTPN11 SPRED1
8 right inferior vena cava connecting to left-sided atrium 10.0 CRELD1 GATA4
9 ventricular septal defect 10.0
10 left superior vena cava persisting to left-sided atrium 10.0 CRELD1 GATA4
11 persistent eustachian valve 10.0 CRELD1 GATA4
12 congenital benign spinal muscular atrophy dominant 10.0 CRELD1 GATA4
13 pauciarticular chronic arthritis 10.0 CRELD1 GATA4
14 third-degree atrioventricular block 10.0 GATA4 TBX5
15 chromosome 15q11-q13 duplication syndrome 10.0 PTPN11 SOS1 SPRED1
16 cardiomyopathy, dilated, 1r 10.0 PTPN11 SPRED1
17 leopard syndrome 3 10.0 PTPN11 SOS1 SPRED1
18 tetralogy of fallot 9.9
19 metachondromatosis 9.9 PTPN11 SOS1 SPRED1
20 hyperproinsulinemia 9.9 PTPN11 SOS1
21 paget disease, extramammary 9.9 CRELD1 NKX2-6
22 huriez syndrome 9.9 CRELD1 NKX2-6
23 dentine erosion 9.9 GATA4 NKX2-6 TBX5
24 endocarditis 9.9
25 pericardium disease 9.9 CRELD1 NKX2-6
26 macroglossia 9.8 CRELD1 GATA4 NKX2-6
27 trichodental syndrome 9.8 CRELD1 GATA4 NKX2-6
28 hypogonadotropic hypogonadism 12 with or without anosmia 9.8 CRELD1 GATA4 NKX2-6
29 testicular germ cell tumor non-seminomatous 9.8 CRELD1 JAG1 NKX2-6
30 congestive heart failure 9.8
31 hypoplastic left heart syndrome 9.8
32 cardiomyopathy 9.8
33 malignant pineal area germ cell neoplasm 9.8 GATA4 JAG1 NKX2-6 TBX5
34 xanthogranulomatous pyelonephritis 9.8 GATA4 NKX2-6 PTPN11 TBX5
35 prune belly syndrome 9.6
36 ataxia-telangiectasia 9.6
37 hemophilia a 9.6
38 tricuspid atresia 9.6
39 pulmonary atresia with intact ventricular septum 9.6
40 infective endocarditis 9.6
41 sarcoma 9.6
42 pulmonary edema 9.6
43 patent foramen ovale 9.6
44 patent ductus arteriosus 9.6
45 purpura 9.6
46 cerebritis 9.6
47 tricuspid valve insufficiency 9.6
48 malignant hyperthermia 9.6
49 pulmonary embolism 9.6
50 muscular dystrophy 9.6

Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to Pulmonary Valve Stenosis

Symptoms & Phenotypes for Pulmonary Valve Stenosis

MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 GATA4 JAG1 NKX2-6 PTPN11 SOS1 TBX5
2 embryo MP:0005380 9.8 GATA4 JAG1 NKX2-6 PTPN11 SOS1 TBX5
3 growth/size/body region MP:0005378 9.8 GATA4 JAG1 NKX2-6 PTPN11 SOS1 SPRED1
4 limbs/digits/tail MP:0005371 9.46 GATA4 PTPN11 SPRED1 TBX5
5 muscle MP:0005369 9.35 GATA4 JAG1 PTPN11 SOS1 TBX5
6 normal MP:0002873 9.02 GATA4 JAG1 NKX2-6 PTPN11 TBX5

Drugs & Therapeutics for Pulmonary Valve Stenosis

Drugs for Pulmonary Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
2
Dobutamine Approved Phase 4 34368-04-2 36811
3 Phosphodiesterase 5 Inhibitors Phase 4
4 Phosphodiesterase Inhibitors Phase 4
5 Sildenafil Citrate Phase 4 171599-83-0
6 Vasodilator Agents Phase 4,Phase 2,Phase 3
7 Peripheral Nervous System Agents Phase 4,Phase 2
8 Anti-Arrhythmia Agents Phase 4
9 Adrenergic Agents Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic beta-Agonists Phase 4
12 Autonomic Agents Phase 4
13 Neurotransmitter Agents Phase 4
14 Protective Agents Phase 4
15 Simendan Phase 4
16 Citrate Nutraceutical Phase 4
17
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
18
Diltiazem Approved Phase 2, Phase 3 42399-41-7 39186
19
Apixaban Approved Phase 3 503612-47-3 10182969
20 Antihypertensive Agents Phase 2, Phase 3,Phase 1
21 calcium channel blockers Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Anticoagulants Phase 3
24 HIV Protease Inhibitors Phase 3
25
protease inhibitors Phase 3
26 Antithrombin III Phase 3
27 Antithrombins Phase 3
28 Factor Xa Inhibitors Phase 3
29 Serine Proteinase Inhibitors Phase 3
30 serine Nutraceutical Phase 3
31
Bosentan Approved, Investigational Phase 1, Phase 2 147536-97-8 104865
32
Minoxidil Approved Phase 2 38304-91-5 4201
33
Ethanol Approved Phase 2 64-17-5 702
34
Cyclosporine Approved, Investigational, Vet_approved Phase 2 79217-60-0, 59865-13-3 5284373 6435893
35
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
36
Dipyridamole Approved Phase 2 58-32-2 3108
37
Everolimus Approved Phase 2 159351-69-6 6442177
38
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
39
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
40
Pirfenidone Investigational Phase 2 53179-13-8 40632
41 Endothelin Receptor Antagonists Phase 1, Phase 2
42 Anti-Infective Agents Phase 2
43 Anti-Infective Agents, Local Phase 2
44 Central Nervous System Depressants Phase 2
45 Analgesics Phase 2
46 Analgesics, Non-Narcotic Phase 2
47 Anti-Inflammatory Agents Phase 2
48 Anti-Inflammatory Agents, Non-Steroidal Phase 2
49 Antirheumatic Agents Phase 2
50 Antifungal Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 103)
id Name Status NCT ID Phase
1 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed NCT01060020 Phase 4
2 Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study Recruiting NCT01275339 Phase 4
3 COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction Not yet recruiting NCT02987387 Phase 4
4 The Effects of Dobutamine on Postoperative Cardiac Function in Aortic Valve Replacement Suspended NCT01375335 Phase 4
5 Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study Terminated NCT01272388 Phase 4
6 Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy Terminated NCT01188369 Phase 4
7 Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation Unknown status NCT02071654 Phase 3
8 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
9 Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem Completed NCT00319982 Phase 2, Phase 3
10 COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction Recruiting NCT02744677 Phase 3
11 Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis Recruiting NCT02664649 Phase 3
12 Bosentan for Severe Mitral Valve Dysfunction Unknown status NCT01270750 Phase 1, Phase 2
13 Efficacy of Minoxidil in Children With Williams-Beuren Syndrome Completed NCT00876200 Phase 2
14 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
15 Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle Completed NCT00001960 Phase 2
16 Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study Completed NCT00035386 Phase 2
17 Pirfenidone to Treat Hypertrophic Cardiomyopathy Completed NCT00011076 Phase 2
18 Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM) Completed NCT00001965 Phase 2
19 A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy Completed NCT00001894 Phase 2
20 Study of Blood Flow in Heart Muscle Completed NCT00001631 Phase 2
21 Systemic Rapamycin (Sirolimus) to Prevent In-Stent Restenosis Following Pulmonary Artery Stent Placement Recruiting NCT02365415 Phase 2
22 Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM Recruiting NCT01912534 Phase 2
23 NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation Not yet recruiting NCT03015194 Phase 2
24 Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop... Completed NCT00001396 Phase 1
25 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery Recruiting NCT02374229 Phase 1
26 Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access Enrolling by invitation NCT02280824 Phase 1
27 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
28 Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease Unknown status NCT00830726
29 Identification of Parameters in rapId-proGression Subgroup Patients With Moderate Aortic Stenosis Unknown status NCT01575249
30 Stroke Volume Analysis During Aortic Valve Replacement Trial Unknown status NCT02156856
31 Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study Unknown status NCT02424994
32 Refining Information Technology Support for Genetics in Medicine Unknown status NCT01225978
33 Pulmonary Arteriopathy-Diagnostics and Therapy Completed NCT00266175
34 Follow Up on Freestyle Valves in Children Completed NCT00385112
35 Retrospective Pulmonary Valve Replacement Imaging Completed NCT00446108
36 CryoValve SG Pulmonary Human Heart Valve Post Clearance Study Completed NCT01092442
37 Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects Completed NCT00004361
38 Early Re-intervention in Infants and Small Children After Correction of Tetralogy of Fallot Completed NCT00536432
39 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
40 The Effect of Transaortic Valve Replacement on the Endothelial Integrity and Function Completed NCT01993485
41 Electrophysiologic HV-interval as a Predicor for Permanent Pacemaker Implantation After TAVI Completed NCT01801098
42 Cerebral Oxymetry at Elective Coronary and Valve Surgery. Completed NCT01940874
43 X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development Completed NCT00965679
44 Inflammatory Response to Aortic Valve Replacement Completed NCT03074838
45 Balloon Valvuloplasty Registry Completed NCT00005199
46 The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery Completed NCT00348920
47 Logical Analysis of Data and Cardiac Surgery Risk Completed NCT00081666
48 Filling Pressures of the Left Ventricle in Patients With Significant Aortic Stenosis Completed NCT01727310
49 The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy Completed NCT00074880
50 Screening for Inherited Heart Disease Completed NCT00001746

Search NIH Clinical Center for Pulmonary Valve Stenosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pulmonary valve stenosis

Genetic Tests for Pulmonary Valve Stenosis

Genetic tests related to Pulmonary Valve Stenosis:

id Genetic test Affiliating Genes
1 Pulmonary Valve Stenosis (rare) 29

Anatomical Context for Pulmonary Valve Stenosis

MalaCards organs/tissues related to Pulmonary Valve Stenosis:

39
Heart, Lung

Publications for Pulmonary Valve Stenosis

Articles related to Pulmonary Valve Stenosis:

(show top 50) (show all 166)
id Title Authors Year
1
EP08.08: Critical pulmonary valve stenosis in dichorionic and diamniotic twins: prenatal diagnosis, pregnancy outcomes and postnatal development. ( 27646419 )
2016
2
Percutaneous balloon valvuloplasty in carcinoid pulmonary valve stenosis. ( 27976548 )
2016
3
Case 4/2016: 32-Year-Old Female, with Critical Pulmonary Valve Stenosis. Operated at 4 Months of Age, in Normal Healing Evolution. ( 27409129 )
2016
4
Dual-Source Computed Tomography Evaluation of Children with Congenital Pulmonary Valve Stenosis. ( 27703660 )
2016
5
Long-Term Outcomes of Balloon Valvuloplasty for Isolated Pulmonary Valve Stenosis. ( 27826708 )
2016
6
Balloon valvuloplasty in dysplastic pulmonary valve stenosis: immediate and intermediate outcomes. ( 25604363 )
2015
7
Restrictive right ventricular performance assessed by cardiac magnetic resonance after balloon valvuloplasty of critical pulmonary valve stenosis. ( 26095337 )
2015
8
Henoch-SchAPnlein purpura secondary to infective endocarditis in a patient with pulmonary valve stenosis and a ventricular septal defect. ( 25995673 )
2015
9
Right juxtaposition and a tunnel between the atrial appendages in a patient with atrial septal defect and pulmonary valve stenosis. ( 25548354 )
2015
10
Prosthetic Pulmonary Valve Stenosis: A Different Way to Solve the Problem. ( 26354643 )
2015
11
Percutaneous Pulmonary Balloon Valvuloplasty Provides Good Long-Term Outcomes in Adults With Pulmonary Valve Stenosis. ( 26301562 )
2015
12
Interventional Treatment of Pulmonary Valve Stenosis: A Single Center Experience. ( 27275259 )
2015
13
Rebuttal: Percutaneous balloon dilation of severe pulmonary valve stenosis in patients with cyanosis and congestive heart failure. ( 24554586 )
2014
14
A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis. ( 24498650 )
2014
15
Comparison of medium-term results of transcatheter correction versus surgical treatment for secundum type atrial septal defect combined with pulmonary valve stenosis. ( 24898601 )
2014
16
Immediate- and medium-term effects of simultaneous percutaneous corrections of secundum type atrial septal defect combined with pulmonary valve stenosis in local anesthesia and without transesophageal echocardiography guidance. ( 24842233 )
2014
17
Functional and haemodynamic assessment of mild-to-moderate pulmonary valve stenosis at rest and during exercise. ( 24780907 )
2014
18
Utility of live/real time three-dimensional transesophageal echocardiography in the assessment and percutaneous intervention of bioprosthetic pulmonary valve stenosis. ( 24646027 )
2014
19
Stenting of the right ventricular outflow tract in 2 dogs for palliation of dysplastic pulmonary valve stenosis and right-to-left intracardiac shunting defects. ( 25087648 )
2014
20
Staged pulmonary valve balloon dilatation in patients with severe pulmonary valve stenosis and heart failure. ( 24677571 )
2014
21
Alpha blocker and angiotensin-converting enzyme inhibitor in the management of severe pulmonary valve stenosis: from bench to bedside. ( 25543957 )
2014
22
Long-term results of percutaneous balloon valvuloplasty in pulmonary valve stenosis in the pediatric population. ( 24774730 )
2014
23
Pulmonary valve regurgitation following balloon valvuloplasty for pulmonary valve stenosis: Single center experience. ( 24688230 )
2013
24
Long-term Results of Balloon Pulmonary Valvuloplasty in Children with Congenital Pulmonary Valve Stenosis. ( 23550107 )
2013
25
Immediate, short, intermediate and long-term results of balloon valvuloplasty in congenital pulmonary valve stenosis. ( 23737317 )
2013
26
Transjugular Balloon Pulmonary Valvuloplasty Through a Bidirectional Glenn Shunt for Dysplastic Pulmonary Valve Stenosis in an 8.7-Year-Old Boy with Inaccessible Femoral Veins. ( 24103403 )
2013
27
Delayed Success of Balloon Dilation for Coexisting Pulmonary Valve Stenosis and Sinotubular Narrowing. ( 23803015 )
2013
28
A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis. ( 24513334 )
2013
29
Single left coronary ostium and an anomalous prepulmonic right coronary artery in 2 dogs with congenital pulmonary valve stenosis. ( 23660401 )
2013
30
The Comparison between the Echocardiographic Data to the Cardiac Catheterization Data on the Diagnosis, Treatment, and Follow-Up in Patients Diagnosed as Pulmonary Valve Stenosis. ( 23560138 )
2013
31
Percutaneous balloon dilation of severe pulmonary valve stenosis in patients with cyanosis and congestive heart failure. ( 24327397 )
2013
32
Percutaneous transluminal pulmonary valvuloplasty in a child with tricuspid atresia, ventricular septal defect, and severe pulmonary valve stenosis: Usefulness of the Femoral Artery Approach. ( 24030841 )
2013
33
Assessment of the vortex flow in the post-stenotic dilatation above the pulmonary valve stenosis in an infant using echocardiography vector flow mapping. ( 24135837 )
2013
34
Congenital heart defects in recurrent reciprocal 1q21.1 deletion and duplication syndromes: rare association with pulmonary valve stenosis. ( 23270675 )
2013
35
Endocarditis after balloon dilation of congenital pulmonary valve stenosis. ( 22695764 )
2012
36
Angiotensin converting enzyme inhibitor as an additive treatment after successful balloon dilation of a critical pulmonary valve stenosis. ( 23960668 )
2012
37
Long-term outcome after treatment of isolated pulmonary valve stenosis. ( 21078529 )
2012
38
Critical pulmonary valve stenosis and pulmonary atresia/intact ventricular septum: to lump or split? Examining procedural success and risk for reintervention. ( 22344996 )
2012
39
Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination. ( 21984265 )
2012
40
Severe aortic or pulmonary valve stenosis in premature infants. ( 22464565 )
2012
41
Pulmonary valve stenosis causing massive pulmonary artery aneurysm: a conservative approach. ( 20442668 )
2012
42
Percutaneous balloon valvuloplasty inpatients with pulmonary valve stenosis: a single center experiment. ( 22768462 )
2012
43
"Vanishing" pulmonary valve stenosis. ( 22529602 )
2012
44
Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot. ( 22871643 )
2012
45
Case 4/2011 - 49-year-old man with pulmonary valve stenosis and atrial septal defect as residual lesions after correction of tetralogy of Fallot, which occurred 30 years ago. ( 21894391 )
2011
46
Successful pulmonary valvuloplasty in combined pulmonary valve stenosis and selective left pulmonary artery ectasia. ( 22037711 )
2011
47
Prenatal diagnosis of a rare case of hypoplastic left heart syndrome associated with pulmonary valve stenosis. ( 20204348 )
2010
48
Role of high-pressure balloon valvotomy for resistant pulmonary valve stenosis. ( 20412485 )
2010
49
Primary pulmonary artery sarcoma: surgical management and differential diagnosis with pulmonary embolism and pulmonary valve stenosis. ( 19549039 )
2009
50
Percutaneous balloon valvuloplasty for the treatment of pulmonary valve stenosis in children - a single centre experience. ( 19492249 )
2009

Variations for Pulmonary Valve Stenosis

Expression for Pulmonary Valve Stenosis

Search GEO for disease gene expression data for Pulmonary Valve Stenosis.

Pathways for Pulmonary Valve Stenosis

Pathways related to Pulmonary Valve Stenosis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 PTPN11 SOS1 SPRED1
2
Show member pathways
11.72 PTPN11 SOS1 SPRED1
3
Show member pathways
11.54 PTPN11 SOS1 SPRED1
4
Show member pathways
11.5 PTPN11 SOS1
5
Show member pathways
11.41 PTPN11 SOS1
6
Show member pathways
11.36 PTPN11 SOS1
7 11.29 PTPN11 SOS1
8 11.27 GATA4 TBX5
9
Show member pathways
11.26 PTPN11 SOS1 SPRED1
10 11.24 PTPN11 SOS1
11 11.2 PTPN11 SOS1
12 11.15 PTPN11 SOS1
13 11.13 PTPN11 SOS1
14 11.04 PTPN11 SOS1
15 10.95 PTPN11 SOS1
16
Show member pathways
10.88 PTPN11 SOS1
17 10.82 PTPN11 SOS1
18 10.72 PTPN11 SOS1
19 10.46 GATA4 PTPN11 TBX5

GO Terms for Pulmonary Valve Stenosis

Biological processes related to Pulmonary Valve Stenosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.63 NKX2-6 PTPN11 TBX5
2 epidermal growth factor receptor signaling pathway GO:0007173 9.49 PTPN11 SOS1
3 inner ear development GO:0048839 9.48 JAG1 PTPN11
4 cardiac muscle cell differentiation GO:0055007 9.43 GATA4 TBX5
5 ventricular septum development GO:0003281 9.4 GATA4 TBX5
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.37 PTPN11 SOS1
7 atrial septum morphogenesis GO:0060413 9.32 GATA4 TBX5
8 cardiac right ventricle morphogenesis GO:0003215 9.26 GATA4 JAG1
9 pericardium development GO:0060039 9.16 NKX2-6 TBX5
10 positive regulation of cardioblast differentiation GO:0051891 8.96 GATA4 TBX5
11 endocardial cushion development GO:0003197 8.8 CRELD1 GATA4 TBX5

Sources for Pulmonary Valve Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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