MCID: PLM041
MIFTS: 43

Pulmonary Valve Stenosis malady

Rare diseases, Cardiovascular diseases, Fetal diseases categories
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Summaries for Pulmonary Valve Stenosis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Pulmonary valve stenosis is a heart valve disorder in which outflow of blood from the right ventricle of... more...

MalaCards: Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to noonan syndrome and congenital pulmonary valve stenosis. An important gene associated with Pulmonary Valve Stenosis is JAG1 (jagged 1), and among its related pathways are Protein digestion and absorption and G protein signaling Ras family GTPases in kinase cascades scheme . The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are cardiovascular system and skeleton.

Aliases & Classifications for Pulmonary Valve Stenosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pulmonary valve stenosis 8 43 10 45 62
valvular pulmonary stenosis 43 49
pulmonary stenosis, cause unspecified 8
heart valve pulmonary stenosis 43
valvate pulmonary stenosis 43
valvar pulmonary stenosis 43
pulmonic valve stenosis 8
pulmonary stenosis nos 8
pulmonic stenosis nos 8


External Ids:

Disease Ontology8 DOID:6420
MeSH35 D011666
MESH via Orphanet36 D011666
ICD10 via Orphanet26 Q22.1
SNOMED-CT58 56786000
SNOMED-CT via Orphanet59 56786000
UMLS via Orphanet63 C0034089
ICD1025 I37.0, I37.2

Related Diseases for Pulmonary Valve Stenosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to pulmonary valve stenosis

Symptoms for Pulmonary Valve Stenosis

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Drugs & Therapeutics for Pulmonary Valve Stenosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pulmonary Valve Stenosis

Search NIH Clinical Center for Pulmonary Valve Stenosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pulmonary Valve Stenosis

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Anatomical Context for Pulmonary Valve Stenosis

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33MalaCards
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MalaCards organs/tissues related to Pulmonary Valve Stenosis:

33
Heart, Lung

Animal Models for Pulmonary Valve Stenosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5ELN, JAG1, SOS1, PTPN11
2MP:00053908.4ELN, SOS1, PTPN11, JAG1
3MP:00107718.2SOS1, JAG1, COL5A3, PTPN11
4MP:00053698.0COL5A3, PTPN11, SOS1, JAG1, ELN
5MP:00053767.9ELN, COL5A3, PTPN11, SOS1, JAG1

Publications for Pulmonary Valve Stenosis

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52PubMed
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Articles related to Pulmonary Valve Stenosis:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Percutaneous transluminal pulmonary valvuloplasty in a child with tricuspid atresia, ventricular septal defect, and severe pulmonary valve stenosis: Usefulness of the Femoral Artery Approach. (24030841)
2013
2
Assessment of the vortex flow in the post-stenotic dilatation above the pulmonary valve stenosis in an infant using echocardiography vector flow mapping. (24135837)
2013
3
Long-term Results of Balloon Pulmonary Valvuloplasty in Children with Congenital Pulmonary Valve Stenosis. (23550107)
2013
4
Transjugular Balloon Pulmonary Valvuloplasty Through a Bidirectional Glenn Shunt for Dysplastic Pulmonary Valve Stenosis in an 8.7-Year-Old Boy with Inaccessible Femoral Veins. (24103403)
2013
5
Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot. (22871643)
2012
6
Pulmonary valve stenosis causing massive pulmonary artery aneurysm: a conservative approach. (20442668)
2012
7
Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination. (21984265)
2012
8
"Vanishing" pulmonary valve stenosis. (22529602)
2012
9
Severe aortic or pulmonary valve stenosis in premature infants. (22464565)
2012
10
Endocarditis after balloon dilation of congenital pulmonary valve stenosis. (22695764)
2012
11
Successful pulmonary valvuloplasty in combined pulmonary valve stenosis and selective left pulmonary artery ectasia. (22037711)
2011
12
Acute pulmonary reperfusion hemorrhage: a rare complication after oversized percutaneous balloon valvuloplasty for pulmonary valve stenosis. (19948440)
2009
13
Primary pulmonary artery sarcoma: surgical management and differential diagnosis with pulmonary embolism and pulmonary valve stenosis. (19549039)
2009
14
Percutaneous balloon valvuloplasty for the treatment of pulmonary valve stenosis in children - a single centre experience. (19492249)
2009
15
Late presentation of pulmonary valve stenosis confirmed by cardiovascular magnetic resonance. (18557887)
2008
16
General anesthesia for dental treatment in a Williams syndrome patient with severe aortic and pulmonary valve stenosis: suspected episode of postoperatively malignant hyperthermia. (17683962)
2007
17
Case 6/2007: a ten-year-old child with mild pulmonary valve stenosis. (18066455)
2007
18
Response to: "Echocardiographic assessment of isolated pulmonary valve stenosis: which outpatient doppler gradient has the most clinical validity?". (16500506)
2006
19
Comparative long-term results of surgery versus balloon valvuloplasty for pulmonary valve stenosis in infants and children. (14529989)
2003
20
Right ventricular myocardial sinusoidal-coronary artery connections in critical pulmonary valve stenosis. (9568230)
1998
21
Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis. (9732908)
1998
22
Use of a cerebral angiographic catheter facilitates crossing the pulmonary valve in neonates with critical or severe pulmonary valve stenosis. (9359566)
1997
23
Echocardiographic determinants of clinical course in infants with critical and severe pulmonary valve stenosis. (9120165)
1997
24
Natural course of isolated pulmonary valve stenosis in infants and children utilizing Doppler echocardiography. (9036756)
1997
25
Pulmonary valve stenosis in a patient with ataxia telangiectasia. (8781844)
1996
26
Interruption of aortic arch associated with pulmonary valve stenosis. (7607770)
1995
27
Acute effects of balloon valvuloplasty and pacing on left ventricular performance in children with moderate pulmonary valve stenosis, analysed by systolic and diastolic pressure-volume relationships. (8174588)
1994
28
Right ventricular conduction disturbance after balloon valvuloplasty in congenital pulmonary valve stenosis. (1682725)
1991
29
Success determining factors in percutaneous transluminal balloon valvuloplasty of pulmonary valve stenosis. (2009887)
1991
30
Balloon valvotomy of calcified pulmonary valve stenosis. (2354477)
1990
31
Neonatal cardiology casebook. Emergency pulmonary balloon valvuloplasty of congenital pulmonary valve stenosis. (2138215)
1990
32
Severe acidosis in a neonate with pulmonary valve stenosis: a possible stress inducer of a fatal syndrome of fructose-1, 6-biphosphatase and aldolase deficiency. (2596290)
1989
33
Percutaneous transluminal balloon valvuloplasty of congenital pulmonary valve stenosis, with a special report on infants and neonates. (3351148)
1988
34
Percutaneous balloon valvuloplasty for pulmonary valve stenosis using single or double balloon technique. (3249009)
1988
35
Long-term outcome of patients undergoing surgical repair of isolated pulmonary valve stenosis. Follow-up at 20-30 years. (3180374)
1988
36
Percutaneous transluminal balloon pulmonary valvuloplasty for the relief of pulmonary valve stenosis with special reference to double-balloon technique. (2942026)
1986
37
Negative right ventricular diastolic pressure after operation for pulmonary valve stenosis: the phenomenon and its relation to volume load and conal contraction. (3947487)
1986
38
Coarctation of the aorta associated with pulmonary valve stenosis. (3957471)
1986
39
Noninvasive assessment of pulmonary valve stenosis, aortic valve stenosis and coarctation of the aorta in critically ill neonates. (3946241)
1986
40
Cyanosis after surgical correction of pulmonary valve stenosis: an old problem revisited. (15227016)
1985
41
Relief of pulmonary valve stenosis in first week of life by percutaneous balloon valvuloplasty. (6143008)
1984
42
Percutaneous transluminal balloon valvuloplasty for pulmonary valve stenosis. (6229366)
1984
43
"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency. (519671)
1979
44
'Isolated' pulmonary valve stenosis as part of more widespread cardiovascular disease. (944584)
1976
45
Selection of patients for surgical correction of ventricular septal defect, congenital aortic valve stenosis, and pulmonary valve stenosis. (4415708)
1974
46
Pulmonary valve stenosis. (5415102)
1970
47
Severe pulmonary valve stenosis and atresia. (4881398)
1968
48
Combined mitral and pulmonary valve stenosis. (5904222)
1966
49
THE ELECTROCARDIOGRAM IN PULMONARY VALVE STENOSIS WITH INTACT VENTRICULAR SEPTUM. (14196130)
1964
50
The operative management of pulmonary valvotomy for pulmonary valve stenosis with normal aortic root. (14380814)
1955

Variations for Pulmonary Valve Stenosis

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Expression for genes affiliated with Pulmonary Valve Stenosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Valve Stenosis

Search GEO for disease gene expression data for Pulmonary Valve Stenosis.

Pathways for genes affiliated with Pulmonary Valve Stenosis

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 54R&D Systems, 53QIAGEN, 61Tocris Bioscience
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Pathways related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4COL5A3, ELN
2
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.4PTPN11, SOS1
39.4SOS1, PTPN11
4
Show member pathways
9.4SOS1, PTPN11
59.4PTPN11, SOS1
6
Show member pathways
9.4PTPN11, SOS1
7
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.4SOS1, PTPN11
8
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.4SOS1, PTPN11
9
Show member pathways
Development Flt3 signaling60
9.4SOS1, PTPN11
10
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.4PTPN11, SOS1
119.4PTPN11, SOS1
12
Show member pathways
9.4SOS1, PTPN11
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.4PTPN11, SOS1
149.4PTPN11, SOS1
15
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.4SOS1, PTPN11
169.4SOS1, PTPN11
17
Show member pathways
Type III interferon signaling38
9.4SOS1, PTPN11
18
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.4PTPN11, SOS1
19
Show member pathways
9.4PTPN11, SOS1
20
Show member pathways
9.4SOS1, PTPN11
21
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4SOS1, PTPN11
229.4SOS1, PTPN11
23
Show member pathways
TCR signaling in naive CD8+ T cells38
9.4PTPN11, SOS1
249.4PTPN11, SOS1
25
Show member pathways
Insulin Pathway38
9.4SOS1, PTPN11
269.4SOS1, PTPN11
279.4PTPN11, SOS1
28
Show member pathways
9.4SOS1, PTPN11
299.4SOS1, PTPN11
309.4SOS1, PTPN11
31
Show member pathways
9.4PTPN11, SOS1
329.4PTPN11, SOS1
339.4SOS1, PTPN11
34
Show member pathways
IL2 signaling events mediated by STAT538
9.4SOS1, PTPN11
359.4PTPN11, SOS1
36
Show member pathways
9.4PTPN11, SOS1
37
Show member pathways
VEGFR1 specific signals38
9.4PTPN11, SOS1
389.4SOS1, PTPN11
39
Show member pathways
IL-2 Signaling pathway38
9.4SOS1, PTPN11
409.4SOS1, PTPN11
41
Show member pathways
9.4SOS1, PTPN11
42
Show member pathways
EPO Receptor Signaling38
EPO signaling pathway38
9.4PTPN11, SOS1
43
Show member pathways
8.8COL5A3, ELN, SOS1
44
Show member pathways
8.8SOS1, ELN, COL5A3
458.2PTPN11, SOS1, JAG1, SLC35B2

Compounds for genes affiliated with Pulmonary Valve Stenosis

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GO Terms for genes affiliated with Pulmonary Valve Stenosis

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16Gene Ontology
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Biological processes related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.4ELN, COL5A3
2fibroblast growth factor receptor signaling pathwayGO:0085439.4PTPN11, SOS1
3leukocyte migrationGO:0509009.3SOS1, PTPN11
4insulin receptor signaling pathwayGO:0082869.1PTPN11, SOS1
5axon guidanceGO:0074118.9COL5A3, SOS1, PTPN11

Molecular functions related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.4COL5A3, ELN

Products for genes affiliated with Pulmonary Valve Stenosis

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  • Antibodies
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Sources for Pulmonary Valve Stenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet