MCID: PLM041
MIFTS: 43

Pulmonary Valve Stenosis malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Pulmonary Valve Stenosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pulmonary valve stenosis is a heart valve disorder in which outflow of blood from the right ventricle of... more...

MalaCards: Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to aortic valve stenosis and ventricular septal defect. An important gene associated with Pulmonary Valve Stenosis is JAG1 (jagged 1), and among its related pathways are TSLP Signaling Pathway and Signaling events regulated by Ret tyrosine kinase. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are craniofacial and integument.

Aliases & Classifications for Pulmonary Valve Stenosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pulmonary valve stenosis 8 42 10 44 60
valvular pulmonary stenosis 42 48
pulmonary stenosis, cause unspecified 8
heart valve pulmonary stenosis 42
valvate pulmonary stenosis 42
valvar pulmonary stenosis 42
pulmonic valve stenosis 8
pulmonary stenosis nos 8
pulmonic stenosis nos 8


External Ids:

Disease Ontology8 DOID:6420
MeSH34 D011666
MESH via Orphanet35 D011666
ICD10 via Orphanet26 Q22.1
SNOMED-CT56 56786000
SNOMED-CT via Orphanet57 56786000
UMLS via Orphanet61 C0034089
ICD1025 I37.0, I37.2

Related Diseases for Pulmonary Valve Stenosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pulmonary Valve Stenosis family:

Congenital Pulmonary Valve Stenosis

Diseases related to Pulmonary Valve Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1aortic valve stenosis30.9PDLIM1, ELN
2ventricular septal defect30.6SLC35B2, CLTCL1
3tetralogy of fallot30.6CLTCL1, HIRA, JAG1
4hypertrophic cardiomyopathy30.3PTPN11
5congenital heart defect30.1PTPN11, JAG1
6noonan syndrome30.1PTPN11, MAP2K2, SOS1
7congenital pulmonary valve stenosis10.5
8coronary stenosis10.4
9double outlet right ventricle10.3
10mitral valve stenosis10.3
11tricuspid valve stenosis10.3
12hypoplastic left heart syndrome10.3
13endocarditis10.3
14infective endocarditis10.2
15patent foramen ovale10.1
16pulmonary edema10.1
17ataxia telangiectasia10.1
18cerebritis10.1
19tricuspid valve insufficiency10.1
20malignant hyperthermia10.1
21pulmonary valve insufficiency10.1
22patent ductus arteriosus10.1
23congestive heart failure10.1
24muscular dystrophy10.1
25pulmonary embolism10.1
26pulmonary valve disease10.1
27sarcoma10.1
2818p deletion syndrome10.1
29hemophilia10.1
30williams syndrome10.1
31pulmonary supravalvular stenosis10.1
32pulmonic stenosis10.1
33myeloid leukemia10.0PTPN11
34glioblastoma multiforme10.0PTPN11
35leukemia10.0PTPN11
36cardiofaciocutaneous syndrome10.0MAP2K2
37mitral valve prolapse10.0PDLIM1
38velocardiofacial syndrome10.0HIRA
39juvenile myelomonocytic leukemia10.0PTPN11
40leopard syndrome10.0SOS1, PTPN11
41adenocarcinoma10.0ELN
42supravalvular aortic stenosis10.0ELN, PDLIM1
43short stature10.0SOS1, MAP2K2, PTPN11
44developmental disabilities10.0JAG1, HIRA, PTPN11, ELN
45costello syndrome10.0SOS1, MAP2K2, PTPN11, ELN

Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to pulmonary valve stenosis

Clinical Features for Pulmonary Valve Stenosis

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Drugs & Therapeutics for Pulmonary Valve Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Valve Stenosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Valve Stenosis

Search NIH Clinical Center for Pulmonary Valve Stenosis

Search CenterWatch for Pulmonary Valve Stenosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pulmonary Valve Stenosis

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Anatomical Context for Pulmonary Valve Stenosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pulmonary Valve Stenosis:

32
Heart, Lung

Animal Models for Pulmonary Valve Stenosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5SOS1, JAG1, MAP2K2, HIRA, PTPN11
2MP:00107718.3PTPN11, MAP2K2, JAG1, SOS1, COL5A3
3MP:00053697.9COL5A3, SOS1, JAG1, PTPN11, ELN
4MP:00053767.0ELN, COL5A3, PVR, SOS1, JAG1, MAP2K2

Publications for Pulmonary Valve Stenosis

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Sources:
50PubMed
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Articles related to Pulmonary Valve Stenosis:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Unusual association of aortic valve stenosis with ventricular septal defect and pulmonary atresia: Differentiation from truncus arteriosus with truncal valve stenosis. (23626446)
2013
2
Percutaneous transluminal pulmonary valvuloplasty in a child with tricuspid atresia, ventricular septal defect, and severe pulmonary valve stenosis: Usefulness of the Femoral Artery Approach. (24030841)
2013
3
Long-term Results of Balloon Pulmonary Valvuloplasty in Children with Congenital Pulmonary Valve Stenosis. (23550107)
2013
4
Mini-Konno procedure using a 10 mm handmade valve for pulmonary atresia with intact ventricular septum and severe aortic stenosis. (24336795)
2013
5
Single left coronary ostium and an anomalous prepulmonic right coronary artery in 2 dogs with congenital pulmonary valve stenosis. (23660401)
2013
6
Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination. (21984265)
2012
7
"Vanishing" pulmonary valve stenosis. (22529602)
2012
8
Critical pulmonary valve stenosis and pulmonary atresia/intact ventricular septum: to lump or split? Examining procedural success and risk for reintervention. (22344996)
2012
9
Angiotensin converting enzyme inhibitor as an additive treatment after successful balloon dilation of a critical pulmonary valve stenosis. (23960668)
2012
10
Frequency, determinants and outcome of pulmonary hypertension in patients with aortic valve stenosis. (21946829)
2012
11
Prognostic value of mild-to-moderate pulmonary hypertension in patients with severe aortic valve stenosis undergoing aortic valve replacement. (21969256)
2012
12
Impact of pulmonary hypertension on outcomes after aortic valve replacement for aortic valve stenosis. (21596173)
2011
13
Relief of branch pulmonary artery stenosis reduces pulmonary valve insufficiency in a swine model. (19619782)
2009
14
Acute pulmonary reperfusion hemorrhage: a rare complication after oversized percutaneous balloon valvuloplasty for pulmonary valve stenosis. (19948440)
2009
15
Percutaneous pulmonary valve implantation for treatment of a severe bovine pulmonary stenosis in a child with isolated dextrocardia, ccTGA after double switch repair. (19205778)
2009
16
Effects of balloon valvuloplasty on coronary blood flow in neonates with critical pulmonary valve stenosis assessed with transthoracic Doppler echocardiography. (19101111)
2009
17
Case 2/2009: eight-year-old child with pulmonary valve insufficiency and left pulmonary artery stenosis, as residual defects after tetralogy of fallot repair. (19360250)
2009
18
Balloon dilation of pulmonary valve stenosis in infants less than 3 kg: a 20-year experience. (19496127)
2009
19
Alpha(2)-blocker helps to avoid systemic to pulmonary shunt in a prostaglandin dependent infant with critical pulmonary valve stenosis. (17125639)
2006
20
Anomalous origin of the right coronary artery from the pulmonary artery combined with aortic valve stenosis. (15620981)
2005
21
Triple-balloon pulmonary valvuloplasty: an advantageous technique for percutaneous repair of pulmonary valve stenosis in the large pediatric and adult patients. (16216023)
2005
22
Initial and late results after catheter intervention for neonatal critical pulmonary valve stenosis and atresia with intact ventricular septum: a technique in continual evolution. (12112896)
2002
23
Absent pulmonary valve with tricuspid atresia or severe tricuspid stenosis: report of three cases and review of the literature. (10890251)
2000
24
Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis: diagnosis by polymerase chain reaction. (11112222)
2000
25
Balloon valvuloplasty of critical pulmonary valve stenosis in a premature neonate. (9986894)
1999
26
Lecompte operation with preservation of the pulmonary valve for anomalies of ventriculoarterial connection with ventricular septal defect and subpulmonary stenosis. (8855434)
1996
27
Treatment of critical pulmonary valve stenosis by balloon dilatation in the neonate. (8615288)
1996
28
Percutaneous transluminal balloon valvuloplasty for pulmonary valve stenosis: report on six cases. (8062769)
1994
29
Syndrome of combined aortic and pulmonary valve stenosis: successful treatment with balloon dilatation. (8197996)
1994
30
Right ventricular conduction disturbance after balloon valvuloplasty in congenital pulmonary valve stenosis. (1682725)
1991
31
Balloon valvotomy of calcified pulmonary valve stenosis. (2354477)
1990
32
Neonatal cardiology casebook. Emergency pulmonary balloon valvuloplasty of congenital pulmonary valve stenosis. (2138215)
1990
33
Tetralogy of Fallot, pulmonary valve stenosis, ventricular septal defect, and hypertrophic cardiomyopathy in WKY/NCrj rats. (2140601)
1990
34
Intraoperative balloon valvuloplasty in pulmonary valve stenosis. (2513116)
1989
35
Long-term outcome of patients undergoing surgical repair of isolated pulmonary valve stenosis. Follow-up at 20-30 years. (3180374)
1988
36
Percutaneous transluminal balloon pulmonary valvuloplasty for the relief of pulmonary valve stenosis with special reference to double-balloon technique. (2942026)
1986
37
Negative right ventricular diastolic pressure after operation for pulmonary valve stenosis: the phenomenon and its relation to volume load and conal contraction. (3947487)
1986
38
Coarctation of the aorta associated with pulmonary valve stenosis. (3957471)
1986
39
Balloon angioplasty in the treatment of pulmonary valve stenosis and coarctation of the aorta. (15227346)
1986
40
Echocardiographic demonstration of pulmonary valve vegetation in a child with infundibular pulmonic stenosis and closed VSD. (3552961)
1986
41
Familial pulmonary valve stenosis, atrial septal defect, and unique electrocardiogram abnormalities. (4045962)
1985
42
A rare case of an adult with mitral, pulmonary and tricuspid valve stenosis with an interatrial communication and acquired cyanosis. (6500622)
1984
43
Pulmonary valve agenesis and supravalvular pulmonary stenosis. Report of a case and review of literature. (6519391)
1984
44
Non-invasive assessment of pulmonary valve stenosis with a multigate pulsed Doppler system. (6652003)
1983
45
Critical pulmonary valve stenosis with intact ventricular septum. (462464)
1979
46
Proceedings: 'Isolated' pulmonary valve stenosis: a possible misnomer. (1259863)
1976
47
Long-term results of surgical treatment for pulmonary valve stenosis. (942233)
1976
48
A family with congenital pulmonary valve stenosis. (4847731)
1974
49
Blood cysts of the pulmonary valve producing pulmonic stenosis. A successful surgical treatment. (5701802)
1968
50
The operative management of pulmonary valvotomy for pulmonary valve stenosis with normal aortic root. (14380814)
1955

Genetic Variations for Pulmonary Valve Stenosis

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Expression for genes affiliated with Pulmonary Valve Stenosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Valve Stenosis

Search GEO for disease gene expression data for Pulmonary Valve Stenosis.

Pathways for genes affiliated with Pulmonary Valve Stenosis

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PTPN11, MAP2K2
29.8PTPN11, SOS1
3
Hide members
9.8PTPN11, SOS1
49.8PTPN11, SOS1
59.8SOS1, PTPN11
6
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.8SOS1, PTPN11
79.8SOS1, PTPN11
89.8SOS1, PTPN11
99.8SOS1, PTPN11
109.8SOS1, PTPN11
119.8PTPN11, SOS1
12
Hide members
9.7SOS1, MAP2K2
13
Hide members
9.7SOS1, MAP2K2
14
Hide members
9.7MAP2K2, SOS1
15
Hide members
9.7MAP2K2, SOS1
16
Hide members
9.7MAP2K2, SOS1
17
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.4SOS1, MAP2K2, PTPN11
189.4SOS1, MAP2K2, PTPN11
199.4SOS1, MAP2K2, PTPN11
20
Development Prolactin receptor signaling
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9.4SOS1, MAP2K2, PTPN11
21
Development FGF-family signaling
Hide members
9.4SOS1, MAP2K2, PTPN11
229.4SOS1, MAP2K2, PTPN11
23
Hide members
9.4SOS1, MAP2K2, PTPN11
24
Hide members
9.4SOS1, MAP2K2, PTPN11
259.4PTPN11, MAP2K2, SOS1
26
Hide members
9.4PTPN11, MAP2K2, SOS1
27
Translation Insulin regulation of translation
Hide members
9.4PTPN11, MAP2K2, SOS1
289.4PTPN11, MAP2K2, SOS1
299.4PTPN11, MAP2K2, SOS1
309.4PTPN11, MAP2K2, SOS1
31
Hide members
9.4PTPN11, MAP2K2, SOS1
329.4PTPN11, MAP2K2, SOS1
33
Hide members
9.4PTPN11, MAP2K2, SOS1
34
Hide members
9.4PTPN11, MAP2K2, SOS1
35
Immune response IL-2 activation and signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
36
Development EPO-induced Jak-STAT pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
37
Hide members
9.4PTPN11, MAP2K2, SOS1
38
Hide members
9.4PTPN11, MAP2K2, SOS1
39
Immune response IL-6 signaling pathway
Hide members
9.4PTPN11, MAP2K2, SOS1
40
Hide members
9.4PTPN11, MAP2K2, SOS1
41
Hide members
9.4PTPN11, MAP2K2, SOS1
42
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.4PTPN11, MAP2K2, SOS1
43
Hide members
9.4PTPN11, MAP2K2, SOS1
449.4PTPN11, MAP2K2, SOS1
459.0JAG1, MAP2K2, SLC35B2, PTPN11
46
Hide members
8.9COL5A3, SOS1, MAP2K2
47
Hide members
8.9COL5A3, SOS1, MAP2K2
48
Hide members
8.9COL5A3, SOS1, MAP2K2
49
Hide members
8.6COL5A3, SOS1, MAP2K2, PTPN11
50
Hide members
8.4ELN, MAP2K2, SOS1, COL5A3

Compounds for genes affiliated with Pulmonary Valve Stenosis

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GO Terms for genes affiliated with Pulmonary Valve Stenosis

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16Gene Ontology
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Biological processes related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:0082869.5PTPN11, MAP2K2, SOS1
2fibroblast growth factor receptor signaling pathwayGO:0085439.4SOS1, MAP2K2, PTPN11
3neurotrophin TRK receptor signaling pathwayGO:0480119.4PTPN11, MAP2K2, SOS1
4Fc-epsilon receptor signaling pathwayGO:0380959.3PTPN11, MAP2K2, SOS1
5epidermal growth factor receptor signaling pathwayGO:0071739.1SOS1, MAP2K2, PTPN11
6axon guidanceGO:0074118.7PTPN11, MAP2K2, SOS1, COL5A3

Products for genes affiliated with Pulmonary Valve Stenosis

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  • Antibodies
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Sources for Pulmonary Valve Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet