MCID: PLM041
MIFTS: 43

Pulmonary Valve Stenosis malady

Rare diseases, Cardiovascular diseases, Fetal diseases categories
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Summaries for Pulmonary Valve Stenosis

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Wikipedia:65 Pulmonary valve stenosis is a heart valve disorder in which outflow of blood from the right ventricle of... more...

MalaCards based summary: Pulmonary Valve Stenosis, also known as valvular pulmonary stenosis, is related to noonan syndrome and congenital pulmonary valve stenosis. An important gene associated with Pulmonary Valve Stenosis is JAG1 (jagged 1), and among its related pathways are Protein digestion and absorption and G protein signaling Ras family GTPases in kinase cascades scheme . The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are cardiovascular system and skeleton.

Aliases & Classifications for Pulmonary Valve Stenosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Pulmonary Valve Stenosis, Aliases & Descriptions:

Name: Pulmonary Valve Stenosis 8 42 10 44 62
Valvular Pulmonary Stenosis 42 48
Pulmonary Stenosis, Cause Unspecified 8
Heart Valve Pulmonary Stenosis 42
Valvate Pulmonary Stenosis 42
 
Valvar Pulmonary Stenosis 42
Pulmonic Valve Stenosis 8
Pulmonary Stenosis Nos 8
Pulmonic Stenosis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:6420
MeSH34 D011666
MESH via Orphanet35 D011666
SNOMED-CT57 56786000
ICD10 via Orphanet26 Q22.1
UMLS via Orphanet63 C0034089
ICD1025 I37.0, I37.2

Related Diseases for Pulmonary Valve Stenosis

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Graphical network of the top 20 diseases related to Pulmonary Valve Stenosis:



Diseases related to pulmonary valve stenosis

Symptoms for Pulmonary Valve Stenosis

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Drugs & Therapeutics for Pulmonary Valve Stenosis

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Drug clinical trials:

Search ClinicalTrials for Pulmonary Valve Stenosis

Search NIH Clinical Center for Pulmonary Valve Stenosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pulmonary Valve Stenosis

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Anatomical Context for Pulmonary Valve Stenosis

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MalaCards organs/tissues related to Pulmonary Valve Stenosis:

32
Heart, Lung

Animal Models for Pulmonary Valve Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Pulmonary Valve Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5ELN, JAG1, SOS1, PTPN11
2MP:00053908.4PTPN11, SOS1, JAG1, ELN
3MP:00107718.2PTPN11, SOS1, JAG1, COL5A3
4MP:00053698.0COL5A3, ELN, JAG1, SOS1, PTPN11
5MP:00053767.9PTPN11, SOS1, JAG1, ELN, COL5A3

Publications for Pulmonary Valve Stenosis

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Articles related to Pulmonary Valve Stenosis:

(show top 50)    (show all 153)
idTitleAuthorsYear
1
Asymptomatic adults with mild/moderate isolated native pulmonary valve stenosis are in need of treatmenta8 (24968883)
but not the
2
Comparison of medium-term results of transcatheter correction versus surgical treatment for secundum type atrial septal defect combined with pulmonary valve stenosis. (24898601)
2014
3
Staged pulmonary valve balloon dilatation in patients with severe pulmonary valve stenosis and heart failure. (24677571)
2014
4
Long-term results of percutaneous balloon valvuloplasty in pulmonary valve stenosis in the pediatric population. (24774730)
2014
5
Utility of live/real time three-dimensional transesophageal echocardiography in the assessment and percutaneous intervention of bioprosthetic pulmonary valve stenosis. (24646027)
2014
6
Immediate- and medium-term effects of simultaneous percutaneous corrections of secundum type atrial septal defect combined with pulmonary valve stenosis in local anesthesia and without transesophageal echocardiography guidance. (24842233)
2014
7
Percutaneous transluminal pulmonary valvuloplasty in a child with tricuspid atresia, ventricular septal defect, and severe pulmonary valve stenosis: Usefulness of the Femoral Artery Approach. (24030841)
2013
8
Assessment of the vortex flow in the post-stenotic dilatation above the pulmonary valve stenosis in an infant using echocardiography vector flow mapping. (24135837)
2013
9
A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis. (24513334)
2013
10
Long-term Results of Balloon Pulmonary Valvuloplasty in Children with Congenital Pulmonary Valve Stenosis. (23550107)
2013
11
Pulmonary valve regurgitation following balloon valvuloplasty for pulmonary valve stenosis: Single center experience. (24688230)
2013
12
Transjugular Balloon Pulmonary Valvuloplasty Through a Bidirectional Glenn Shunt for Dysplastic Pulmonary Valve Stenosis in an 8.7-Year-Old Boy with Inaccessible Femoral Veins. (24103403)
2013
13
Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot. (22871643)
2012
14
Pulmonary valve stenosis causing massive pulmonary artery aneurysm: a conservative approach. (20442668)
2012
15
Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination. (21984265)
2012
16
"Vanishing" pulmonary valve stenosis. (22529602)
2012
17
Successful pulmonary valvuloplasty in combined pulmonary valve stenosis and selective left pulmonary artery ectasia. (22037711)
2011
18
Acute pulmonary reperfusion hemorrhage: a rare complication after oversized percutaneous balloon valvuloplasty for pulmonary valve stenosis. (19948440)
2009
19
Late presentation of pulmonary valve stenosis confirmed by cardiovascular magnetic resonance. (18557887)
2008
20
General anesthesia for dental treatment in a Williams syndrome patient with severe aortic and pulmonary valve stenosis: suspected episode of postoperatively malignant hyperthermia. (17683962)
2007
21
Response to: "Echocardiographic assessment of isolated pulmonary valve stenosis: which outpatient doppler gradient has the most clinical validity?". (16500506)
2006
22
Comparative long-term results of surgery versus balloon valvuloplasty for pulmonary valve stenosis in infants and children. (14529989)
2003
23
Right ventricular myocardial sinusoidal-coronary artery connections in critical pulmonary valve stenosis. (9568230)
1998
24
Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis. (9732908)
1998
25
Use of a cerebral angiographic catheter facilitates crossing the pulmonary valve in neonates with critical or severe pulmonary valve stenosis. (9359566)
1997
26
Echocardiographic determinants of clinical course in infants with critical and severe pulmonary valve stenosis. (9120165)
1997
27
Pulmonary valve stenosis in a patient with ataxia telangiectasia. (8781844)
1996
28
Interruption of aortic arch associated with pulmonary valve stenosis. (7607770)
1995
29
Acute effects of balloon valvuloplasty and pacing on left ventricular performance in children with moderate pulmonary valve stenosis, analysed by systolic and diastolic pressure-volume relationships. (8174588)
1994
30
Right ventricular conduction disturbance after balloon valvuloplasty in congenital pulmonary valve stenosis. (1682725)
1991
31
Success determining factors in percutaneous transluminal balloon valvuloplasty of pulmonary valve stenosis. (2009887)
1991
32
Balloon valvotomy of calcified pulmonary valve stenosis. (2354477)
1990
33
Neonatal cardiology casebook. Emergency pulmonary balloon valvuloplasty of congenital pulmonary valve stenosis. (2138215)
1990
34
Severe acidosis in a neonate with pulmonary valve stenosis: a possible stress inducer of a fatal syndrome of fructose-1, 6-biphosphatase and aldolase deficiency. (2596290)
1989
35
Percutaneous transluminal balloon valvuloplasty of congenital pulmonary valve stenosis, with a special report on infants and neonates. (3351148)
1988
36
Percutaneous balloon valvuloplasty for pulmonary valve stenosis using single or double balloon technique. (3249009)
1988
37
Long-term outcome of patients undergoing surgical repair of isolated pulmonary valve stenosis. Follow-up at 20-30 years. (3180374)
1988
38
Percutaneous transluminal balloon pulmonary valvuloplasty for the relief of pulmonary valve stenosis with special reference to double-balloon technique. (2942026)
1986
39
Negative right ventricular diastolic pressure after operation for pulmonary valve stenosis: the phenomenon and its relation to volume load and conal contraction. (3947487)
1986
40
Coarctation of the aorta associated with pulmonary valve stenosis. (3957471)
1986
41
Noninvasive assessment of pulmonary valve stenosis, aortic valve stenosis and coarctation of the aorta in critically ill neonates. (3946241)
1986
42
Relief of pulmonary valve stenosis in first week of life by percutaneous balloon valvuloplasty. (6143008)
1984
43
Percutaneous transluminal balloon valvuloplasty for pulmonary valve stenosis. (6229366)
1984
44
'Isolated' pulmonary valve stenosis as part of more widespread cardiovascular disease. (944584)
1976
45
Selection of patients for surgical correction of ventricular septal defect, congenital aortic valve stenosis, and pulmonary valve stenosis. (4415708)
1974
46
Pulmonary valve stenosis. (5415102)
1970
47
Severe pulmonary valve stenosis and atresia. (4881398)
1968
48
Combined mitral and pulmonary valve stenosis. (5904222)
1966
49
THE ELECTROCARDIOGRAM IN PULMONARY VALVE STENOSIS WITH INTACT VENTRICULAR SEPTUM. (14196130)
1964
50
The operative management of pulmonary valvotomy for pulmonary valve stenosis with normal aortic root. (14380814)
1955

Variations for Pulmonary Valve Stenosis

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Expression for genes affiliated with Pulmonary Valve Stenosis

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Expression patterns in normal tissues for genes affiliated with Pulmonary Valve Stenosis

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Pathways for genes affiliated with Pulmonary Valve Stenosis

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Pathways related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4COL5A3, ELN
2
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.4PTPN11, SOS1
39.4SOS1, PTPN11
4
Show member pathways
9.4SOS1, PTPN11
59.4PTPN11, SOS1
6
Show member pathways
9.4PTPN11, SOS1
7
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.4SOS1, PTPN11
8
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.4SOS1, PTPN11
9
Show member pathways
Development Flt3 signaling60
9.4SOS1, PTPN11
10
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
9.4PTPN11, SOS1
119.4PTPN11, SOS1
12
Show member pathways
9.4SOS1, PTPN11
13
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.4PTPN11, SOS1
149.4PTPN11, SOS1
15
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.4SOS1, PTPN11
169.4SOS1, PTPN11
17
Show member pathways
Type III interferon signaling37
9.4SOS1, PTPN11
18
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.4PTPN11, SOS1
19
Show member pathways
9.4PTPN11, SOS1
20
Show member pathways
9.4SOS1, PTPN11
21
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4SOS1, PTPN11
229.4SOS1, PTPN11
23
Show member pathways
TCR signaling in naive CD8+ T cells37
9.4PTPN11, SOS1
249.4PTPN11, SOS1
25
Show member pathways
Insulin Pathway37
9.4SOS1, PTPN11
269.4SOS1, PTPN11
279.4PTPN11, SOS1
28
Show member pathways
9.4SOS1, PTPN11
299.4SOS1, PTPN11
309.4SOS1, PTPN11
31
Show member pathways
9.4PTPN11, SOS1
329.4PTPN11, SOS1
339.4SOS1, PTPN11
34
Show member pathways
IL2 signaling events mediated by STAT537
9.4SOS1, PTPN11
359.4PTPN11, SOS1
36
Show member pathways
9.4PTPN11, SOS1
37
Show member pathways
VEGFR1 specific signals37
9.4PTPN11, SOS1
389.4SOS1, PTPN11
39
Show member pathways
IL-2 Signaling pathway37
9.4SOS1, PTPN11
409.4SOS1, PTPN11
41
Show member pathways
9.4SOS1, PTPN11
42
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
9.4PTPN11, SOS1
43
Show member pathways
8.8COL5A3, ELN, SOS1
44
Show member pathways
8.8SOS1, ELN, COL5A3
458.2PTPN11, SOS1, JAG1, SLC35B2

Compounds for genes affiliated with Pulmonary Valve Stenosis

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GO Terms for genes affiliated with Pulmonary Valve Stenosis

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Biological processes related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.4COL5A3, ELN
2fibroblast growth factor receptor signaling pathwayGO:0085439.4SOS1, PTPN11
3leukocyte migrationGO:0509009.3PTPN11, SOS1
4insulin receptor signaling pathwayGO:0082869.1SOS1, PTPN11
5axon guidanceGO:0074118.9COL5A3, SOS1, PTPN11

Molecular functions related to Pulmonary Valve Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.4COL5A3, ELN

Products for genes affiliated with Pulmonary Valve Stenosis

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Sources for Pulmonary Valve Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet