MCID: PLM070
MIFTS: 48

Pulmonic Stenosis malady

Summaries for Pulmonic Stenosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pulmonic stenosis, also known as Pulmonary stenosis, is a dynamic or fixed obstruction of flow from the... more...

MalaCards: Pulmonic Stenosis, also known as valvular pulmonic stenosis, is related to mental retardation and noonan syndrome. An important gene associated with Pulmonic Stenosis is ZIC3 (Zic family member 3), and among its related pathways are Nongenotropic Androgen signaling and FGFR2c ligand binding and activation. The compounds estrogen and gppnhp have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Pulmonic Stenosis

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

pulmonic stenosis 43
valvular pulmonic stenosis 43
pulmonary stenosis 61


Related Diseases for Pulmonic Stenosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonic Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.3NF1, HRAS, PTPN11, ELN, BRAF
2noonan syndrome30.2PTPN11, KRAS, RAF1, HRAS, MAP2K1, MAP2K2
3leopard syndrome30.1PTPN11, RAF1, HRAS
4cardiofaciocutaneous syndrome30.1KRAS, MAP2K1, MAP2K2, BRAF
5neurofibromatosis29.8PTPN11, HRAS, NF1, KRAS
6ventricular septal defect10.7
7pulmonary supravalvular stenosis10.5
8patent ductus arteriosus10.4
9pulmonary subvalvular stenosis10.4
10subvalvular aortic stenosis10.4
11watson syndrome10.4
12retinal arterial macroaneurysm with supravalvular pulmonic stenosis10.4
13ebstein anomaly10.3
14patent foramen ovale10.3
15n syndrome10.3
16double outlet left ventricle10.3
17atrioventricular septal defect10.2
18heart tumor10.2
19keutel syndrome10.2
20pulmonary function10.2
21hypoplastic left heart syndrome10.2
22williams syndrome10.2
23complete atrioventricular canal10.2
24tricuspid atresia10.2
25marfan syndrome10.1
26pulmonary tuberculosis10.1
27intrahepatic cholestasis10.1
28supravalvular aortic stenosis10.1
29pulmonary edema10.1
30hemosiderosis10.1
31tricuspid valve stenosis10.1
32dextrocardia10.1
33portal hypertension10.1
34alagille syndrome10.1
35situs inversus10.1
36azoospermia10.1
37aortic aneurysm10.1
38atrial heart septal defect10.1
39tuberculosis10.1
40prune belly syndrome10.1
41aortic coarctation10.1
42kartagener syndrome10.1
43x-linked visceral heterotaxy 110.1
44noonan syndrome 110.1
45subpulmonary stenosis10.1
46congenital heart disease, atrial septal defect10.1
47leopard syndrome 110.1
48teratoma10.1
49congenital tricuspid stenosis10.1
50atrial septal aneurysm10.1

Graphical network of the top 20 diseases related to Pulmonic Stenosis:



Diseases related to pulmonic stenosis

Clinical Features for Pulmonic Stenosis

Drugs & Therapeutics for Pulmonic Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pulmonic Stenosis

Drug clinical trials:

Search ClinicalTrials for Pulmonic Stenosis

Search NIH Clinical Center for Pulmonic Stenosis

Search CenterWatch for Pulmonic Stenosis

Genetic Tests for Pulmonic Stenosis

Anatomical Context for Pulmonic Stenosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pulmonic Stenosis:

33
Heart, Liver, Lung, B cells, Fetal liver, Fetal lung

Animal Models for Pulmonic Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pulmonic Stenosis:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.5ZIC3
2MP:000536710.2JAG1
3MP:00011869.4NF1
4MP:00053719.3DTNA, ZIC3, PTPN11
5MP:00053919.2ZIC3, JAG1, MAP2K2, MAP2K1, RAF1
6MP:00053908.8DTNA, ZIC3, NF1, HRAS
7MP:00107718.5JAG1, MAP2K2, MAP2K1, HRAS, RAF1, KRAS
8MP:00053798.3NF1, MAP2K1, HRAS, KRAS, PTPN11
9MP:00053778.2ZIC3, JAG1, NF1, MAP2K2, MAP2K1, PTPN11
10MP:00053768.2JAG1, NF1, MAP2K2, MAP2K1, PTPN11, ELN
11MP:00053888.0ZIC3, NF1, RAF1, KRAS, PTPN11, ELN
12MP:00053817.9ZIC3, BRAF, JAG1, MAP2K2, MAP2K1, KRAS
13MP:00036317.6DTNA, ZIC3, NF1, MAP2K1, HRAS, RAF1
14MP:00053707.3ZIC3, BRAF, JAG1, NF1, RAF1, KRAS
15MP:00053977.0ZIC3, BRAF, JAG1, NF1, RAF1, KRAS
16MP:00053827.0ZIC3, BRAF, JAG1, NF1, MAP2K2, MAP2K1
17MP:00020067.0BRAF, NF1, MAP2K2, MAP2K1, HRAS, RAF1
18MP:00053696.9DTNA, BRAF, JAG1, NF1, RAF1, KRAS
19MP:00053866.8DTNA, ZIC3, BRAF, JAG1, NF1, HRAS
20MP:00053846.8BRAF, JAG1, NF1, MAP2K2, MAP2K1, RAF1
21MP:00028736.5ZIC3, BRAF, JAG1, NF1, MAP2K2, MAP2K1
22MP:00053856.0ELN, DTNA, ZIC3, BRAF, JAG1, NF1
23MP:00053785.9DTNA, ZIC3, BRAF, JAG1, NF1, MAP2K2
24MP:00107685.6DTNA, ZIC3, BRAF, JAG1, NF1, MAP2K2

Publications for Pulmonic Stenosis

Sources:
51PubMed
See all sources

Articles related to Pulmonic Stenosis:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Transcatheter intravascular stent placement to relieve supravalvular pulmonic stenosis. (19083348)
2006
2
Balloon valvuloplasty of valvular pulmonic stenosis in the dog. (16180401)
2005
3
Balloon valvuloplasty in a cat with pulmonic stenosis. (14658733)
2003
4
Successful combined orthotopic liver transplant and transcatheter management of atrial septal defect, patent ductus arteriosus, and peripheral pulmonic stenosis in a small infant with Alagille syndrome. (12530500)
2002
5
Congenital Pulmonic Stenosis a Retrospective study of 24 cases seen between 1990-1999. (19081338)
2001
6
Pre-natal echocardiographic diagnosis and neonatal balloon dilatation of severe valvar pulmonic stenosis. (10798141)
1999
7
Pulmonic stenosis in adolescents and adults. (8965871)
1996
8
Comparison of occurrence of genetic syndromes in ventricular septal defect with pulmonic stenosis (classic tetralogy of Fallot) versus ventricular septal defect with pulmonic atresia. (8677886)
1996
9
Use of a modified open patch-graft technique and valvulectomy for correction of severe pulmonic stenosis in dogs: eight consecutive cases. (8368965)
1993
10
Physiologic peripheral pulmonic stenosis in infancy. (2251995)
1990
11
An open patch-graft technique for correction of pulmonic stenosis in the dog. (2333687)
1990
12
A case of pulmonic stenosis with single coronary artery in a dog. (2739227)
1989
13
Detection by Doppler echocardiography of acquired pulmonic stenosis due to extrinsic tumor compression. (6720600)
1984
14
Severe congestive heart failure in mild pulmonic stenosis due to dysplastic pulmonary valve associated with cardiomyopathy. (6224694)
1983
15
Acquired extrinsic pulmonic stenosis caused by mediastinal tumors. (7059957)
1982
16
Frequency and direction of interatrial shunting in valvular pulmonic stenosis with intact ventricular septum and without left ventricular inflow or outflow obstruction. An analysis of 127 patients treated by valvulotomy. (7352396)
1980
17
Double outlet right ventricle, non-committed ventricular septal defect and pulmonic stenosis. Anatomical and surgical considerations. (6161439)
1980
18
Acquired pulmonic stenosis due to a mediastinal seminoma. (7418471)
1980
19
Use of an extracardiac conduit in the repair of supravalvular pulmonic stenosis in a dog. (148444)
1978
20
Combined tricuspid and pulmonic stenosis. Clinical, echocardiographic, hemodynamic, surgical, and pathological features. (559886)
1977
21
Total anomalous pulmonary venous connection and severe pulmonic stenosis in a 52-year-old man. (830210)
1977
22
Echocardiographic, angiocardiographic, and surgical correlations in right ventricular myxoma simulating valvar pulmonic stenosis. (837505)
1977
23
Giant blood cyst and congenital pulmonic stenosis. Report of a case. (1190181)
1975
24
Experimental infundibular pulmonic stenosis. Effects of positive inotropic agents. (4823305)
1974
25
Pulmonic stenosis in the adult. Long-term follow-up results. (5082217)
1972
26
Pulmonary pseudofibrosis in cyanotic heart disease. A clinical syndrome mimicking tuberculosis in patients with extreme pulmonic stenosis. (5082035)
1972
27
Ventricular septal defects and pulmonic stenosis with and without dextroposition. Anatomic features and embryologic implications. (5571470)
1971
28
Patent ductus arteriosus, aorto-pulmonary artery fenestration, coarctation of the aorta and pulmonic stenosis. (5138242)
1971
29
Chronic fibrous mediastinitis simulating pulmonic stenosis, associated with inflammatory pseudotumor of the orbit. (4230512)
1968
30
Atrial flutter associated with isolated pulmonic stenosis. (4952667)
1967
31
Blind technique valvulotomy for isolated pulmonic stenosis. (4225507)
1967
32
SEVERE PULMONIC STENOSIS WITH INTACT VENTRICULAR SEPTUM AND RIGHT AORTIC ARCH. (14314480)
1965
33
CONGENITAL PULMONIC STENOSIS COMPLICATING EBSTEIN'S ANOMALY OF THE TRICUSPID VALVE. (14222416)
1964
34
COMBINED SUPRAVALVULAR AORTIC AND PULMONIC STENOSIS. (14068767)
1963
35
Use of isoproterenol in the evaluation of aortic and pulmonic stenosis. (13936196)
1963
36
A typical clinical findings in a dog with pulmonic stenosis. (13952359)
1963
37
Combined aortic and pulmonic stenosis. (14477792)
1962
38
Physiologic changes during chronic congestive heart failure in dogs with tricuspid insufficiency and pulmonic stenosis. (13846448)
1959
39
Pulmonic stenosis with intact ventricular septum. (13598316)
1958
40
Regression after open valvotomy of infundibular stenosis accompanying severe valvular pulmonic stenosis. (13537273)
1958
41
Functional changes during high output failure produced by daily hemorrhage in dogs with pulmonic stenosis. (13447182)
1957
42
Pulmonic stenosis: posteroanterior roentogenographic appearance in 15 patients more than 34 years of age. (13485166)
1957
43
Pulmonic stenosis; its surgical treatment. (13279358)
1956
44
Experience in the surgical management of atrial septal defect and pulmonic stenosis under hypothermia. (13381898)
1956
45
Fallot's tetralogy; its differentiation from pulmonic stenosis with intact ventricular septum and an inter-auricular communication (Fallot's trilogy). (12995093)
1952
46
Surgical treatment of pulmonic stenosis with intact ventricular septum. (15420554)
1950
47
Valvular pulmonic stenosis with intact ventricular septum and patent foramen ovale; report of illustrative cases and analysis of clinical syndrome. (14772975)
1950
48
Surgical treatment of pulmonic stenosis. (18880726)
1948
49
Surgical procedures employed and anatomical variations encountered in the treatment of congenital pulmonic stenosis. (18119793)
1948
50
The surgical treatment of congenital pulmonic stenosis. (21000853)
1946

Genetic Variations for Pulmonic Stenosis

Expression for genes affiliated with Pulmonic Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonic Stenosis

Search GEO for disease gene expression data for Pulmonic Stenosis.

Pathways for genes affiliated with Pulmonic Stenosis

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 56SinoBiological, 50PharmGKB, 52QIAGEN, 60Tocris Bioscience, 30KEGG, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Pulmonic Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0MAP2K1, HRAS, RAF1, MAP2K2
2
Hide members
8.7PTPN11, RAF1, KRAS, HRAS
3
Immune response IL-6 signaling pathway
Hide members
8.6PTPN11, RAF1, HRAS, MAP2K1, MAP2K2
4
Immune response IL-2 activation and signaling pathway
Hide members
8.6RAF1, MAP2K2, MAP2K1, HRAS, PTPN11
58.6HRAS, PTPN11, RAF1, MAP2K1, MAP2K2
6
Hide members
8.6MAP2K2, PTPN11, RAF1, HRAS, MAP2K1
7
Development EPO-induced Jak-STAT pathway
Hide members
8.6RAF1, MAP2K1, MAP2K2, HRAS, PTPN11
8
Hide members
8.6MAP2K2, MAP2K1, HRAS, PTPN11, RAF1
98.6MAP2K2, RAF1, HRAS, MAP2K1, PTPN11
108.5KRAS, HRAS, MAP2K1, MAP2K2, RAF1
11
Hide members
8.5RAF1, KRAS, MAP2K2, MAP2K1, HRAS
12
Hide members
8.5KRAS, RAF1, HRAS, MAP2K1, MAP2K2
138.5MAP2K2, MAP2K1, HRAS, RAF1, KRAS
14
Hide members
8.5MAP2K2, MAP2K1, HRAS, RAF1, KRAS
158.4PTPN11, MAP2K2, KRAS, RAF1, HRAS
16
Hide members
8.4HRAS, MAP2K1, MAP2K2, BRAF, RAF1
17
Hide members
8.4RAF1, MAP2K2, HRAS, MAP2K1, BRAF
188.3HRAS, MAP2K1, BRAF, KRAS, MAP2K2
198.2RAF1, KRAS, BRAF, MAP2K2, MAP2K1
20
Hide members
8.1MAP2K2, KRAS, RAF1, HRAS, MAP2K1, PTPN11
21
Hide members
8.1HRAS, RAF1, KRAS, PTPN11, MAP2K2, MAP2K1
22
Hide members
8.1KRAS, PTPN11, HRAS, MAP2K1, RAF1, MAP2K2
23
Hide members
8.1RAF1, HRAS, MAP2K1, MAP2K2, KRAS, PTPN11
24
Hide members
8.1MAP2K2, MAP2K1, KRAS, HRAS, PTPN11, RAF1
258.1KRAS, PTPN11, MAP2K2, MAP2K1, HRAS, RAF1
26
Development Prolactin receptor signaling
Hide members
8.1RAF1, HRAS, MAP2K1, MAP2K2, KRAS, PTPN11
27
Hide members
7.9BRAF, RAF1, NF1, MAP2K2, MAP2K1
28
Hide members
7.9KRAS, HRAS, MAP2K1, MAP2K2, BRAF, RAF1
29
Hide members
7.9HRAS, KRAS, MAP2K1, RAF1, BRAF, MAP2K2
30
Hide members
7.9MAP2K1, RAF1, KRAS, MAP2K2, BRAF, HRAS
31
Hide members
7.9KRAS, BRAF, RAF1, HRAS, MAP2K1, MAP2K2
327.9MAP2K1, MAP2K2, RAF1, KRAS, BRAF, HRAS
33
Hide members
7.9KRAS, MAP2K1, BRAF, MAP2K2, HRAS, RAF1
34
Hide members
7.9BRAF, MAP2K2, HRAS, MAP2K1, RAF1, KRAS
35
Hide members
7.9KRAS, BRAF, MAP2K2, HRAS, RAF1, MAP2K1
36
Hide members
7.9BRAF, MAP2K1, KRAS, RAF1, HRAS, MAP2K2
37
Hide members
7.9BRAF, MAP2K2, HRAS, RAF1, KRAS, MAP2K1
387.8MAP2K2, MAP2K1, RAF1, KRAS, PTPN11, BRAF
397.6NF1, BRAF, MAP2K2, MAP2K1, HRAS, RAF1
40
Hide members
7.4PTPN11, KRAS, MAP2K2, BRAF, HRAS, MAP2K1
417.4HRAS, MAP2K1, MAP2K2, BRAF, PTPN11, KRAS
42
Translation Insulin regulation of translation
Hide members
7.4KRAS, RAF1, PTPN11, HRAS, BRAF, MAP2K2
43
Hide members
7.4KRAS, HRAS, MAP2K2, PTPN11, BRAF, RAF1
44
Hide members
7.4HRAS, MAP2K1, BRAF, MAP2K2, RAF1, KRAS
45
Hide members
7.4MAP2K2, KRAS, RAF1, HRAS, MAP2K1, PTPN11
46
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
7.4RAF1, HRAS, MAP2K1, PTPN11, KRAS, MAP2K2
47
Hide members
7.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
48
Hide members
7.0MAP2K2, NF1, BRAF, KRAS, MAP2K1, HRAS
49
Hide members
7.0BRAF, NF1, MAP2K2, HRAS, MAP2K1, KRAS
50
Hide members
6.6RAF1, KRAS, HRAS, MAP2K1, MAP2K2, BRAF

Compounds for genes affiliated with Pulmonic Stenosis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Pulmonic Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen459.8ELN, NF1
2gppnhp459.7RAF1, HRAS
3gdc 0879609.7BRAF, RAF1
4sb 590885609.7RAF1, BRAF
5l-779,450609.7BRAF, RAF1
6gw 5074609.7BRAF, RAF1
7manumycin459.7RAF1, HRAS, MAP2K1
8gw-5074459.7BRAF, RAF1
9zm 33637245 6010.7BRAF, RAF1
10panitumumab45 50 1111.6KRAS, BRAF
11pd-184352459.5RAF1, MAP2K1, KRAS
12depsipeptide459.4BRAF, ELN, RAF1
13Dabrafenib119.4BRAF, RAF1
1417-(allylamino)-17-demethoxygeldanamycin459.4MAP2K1, RAF1, BRAF
15crcs459.3KRAS, HRAS, BRAF
16ag 1478459.3MAP2K1, PTPN11, RAF1
17herbimycin a45 6010.3PTPN11, HRAS, MAP2K1, RAF1
18gp 130459.2MAP2K1, HRAS, PTPN11
19phosphotyrosine459.1HRAS, MAP2K1, RAF1, PTPN11
20guanosine45 11 2411.1NF1, MAP2K1, HRAS
21lovastatin45 50 60 29 1113.0RAF1, MAP2K1, HRAS
2212-o-tetradecanoylphorbol 13-acetate458.9BRAF, RAF1, HRAS, MAP2K1
23pd 98,059458.8MAP2K2, HRAS, RAF1, MAP2K1, BRAF
24nitric oxide45 11 2410.8HRAS, MAP2K1, MAP2K2, JAG1, PTPN11
25sb 20358045 609.8RAF1, MAP2K1, BRAF, PTPN11
26valine458.7HRAS, BRAF, RAF1, KRAS, ELN
27paclitaxel45 50 1110.6KRAS, RAF1, HRAS, MAP2K1, BRAF
28imatinib45 50 1110.5KRAS, BRAF, MAP2K1, PTPN11, RAF1
29h2o2458.5HRAS, KRAS, PTPN11, RAF1, ELN, MAP2K1
30threonine458.3MAP2K1, BRAF, MAP2K2, HRAS, RAF1, PTPN11
31lysine458.3ELN, PTPN11, MAP2K1, NF1, BRAF
32paraffin458.3BRAF, NF1, KRAS, ELN, HRAS
33forskolin45 50 1110.2NF1, MAP2K1, PTPN11, RAF1, BRAF
34ly294002458.2PTPN11, KRAS, RAF1, BRAF, HRAS, MAP2K1
35cisplatin45 50 60 1111.2PTPN11, RAF1, HRAS, MAP2K1, BRAF, KRAS
36cyclic amp45 249.1MAP2K1, RAF1, NF1, HRAS, BRAF
37agar458.1ELN, BRAF, IGFBP7, MAP2K1, HRAS, RAF1
38gtp45 299.1KRAS, NF1, BRAF, RAF1, HRAS
39cysteine458.1MAP2K1, PTPN11, ELN, NF1, RAF1, HRAS
40arginine458.0ELN, MAP2K1, HRAS, NF1, BRAF, PTPN11
41wortmannin457.9PTPN11, HRAS, MAP2K2, MAP2K1, RAF1, KRAS
42phosphoinositide457.9RAF1, MAP2K2, MAP2K1, BRAF, PTPN11, HRAS
43alanine457.9RAF1, NF1, BRAF, PTPN11, ELN, MAP2K1
44oligonucleotide457.7RAF1, HRAS, KRAS, PTPN11, NF1, BRAF
45vegf457.6HRAS, PTPN11, MAP2K1, ELN, IGFBP7, KRAS
46retinoic acid45 248.2BRAF, ELN, KRAS, NF1, IGFBP7, MAP2K1
47rapamycin457.1KRAS, PTPN11, ELN, RAF1, MAP2K1, BRAF
48phosphatidylinositol457.1BRAF, NF1, MAP2K2, MAP2K1, HRAS, RAF1
49tyrosine457.0RAF1, BRAF, KRAS, NF1, PTPN11, MAP2K2
50serine456.5MAP2K2, BRAF, ELN, PTPN11, KRAS, NF1

GO Terms for genes affiliated with Pulmonic Stenosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Pulmonic Stenosis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1regulation of early endosome to late endosome transportGO:200064110.1MAP2K2, MAP2K1
2regulation of Golgi inheritanceGO:09017010.1MAP2K2, MAP2K1
3regulation of stress-activated MAPK cascadeGO:03287210.1MAP2K1, MAP2K2
4positive regulation of protein serine/threonine kinase activityGO:0719029.9MAP2K1, MAP2K2
5positive regulation of Rac protein signal transductionGO:0350229.9HRAS, KRAS
6striated muscle cell differentiationGO:0511469.9KRAS, HRAS
7cellular senescenceGO:0903989.8HRAS, MAP2K1
8activation of MAPK activityGO:0001879.7PTPN11, MAP2K1, MAP2K2
9organ morphogenesisGO:0098879.5BRAF, HRAS, ELN
10leukocyte migrationGO:0509009.4HRAS, KRAS, PTPN11
11RNA modificationGO:0094519.3IGFBP7, NF1
12cell proliferationGO:0082839.3MAP2K1, HRAS, RAF1, ELN
13negative regulation of cell proliferationGO:0082859.2RAF1, HRAS, MAP2K1, IGFBP7
14regulation of synaptic transmission, GABAergicGO:0322289.1NF1, HRAS, KRAS
15regulation of long-term neuronal synaptic plasticityGO:0481699.1KRAS, HRAS, NF1
16visual learningGO:0085429.1KRAS, HRAS, NF1
17positive regulation of Ras GTPase activityGO:0323209.0MAP2K1, NF1
18actin cytoskeleton organizationGO:0300368.9NF1, HRAS, KRAS
19heart developmentGO:0075078.9NF1, RAF1, PTPN11
20synaptic transmissionGO:0072688.7RAF1, HRAS, BRAF, DTNA
21blood coagulationGO:0075968.6HRAS, RAF1, KRAS, PTPN11
22insulin receptor signaling pathwayGO:0082868.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
23Fc-epsilon receptor signaling pathwayGO:0380958.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
24epidermal growth factor receptor signaling pathwayGO:0071738.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
25axon guidanceGO:0074118.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
26innate immune responseGO:0450878.4MAP2K2, MAP2K1, HRAS, RAF1, KRAS, PTPN11
27activation of MAPKK activityGO:0001868.3KRAS, RAF1, HRAS, MAP2K1, MAP2K2, BRAF
28small GTPase mediated signal transductionGO:0072648.2BRAF, MAP2K2, MAP2K1, HRAS, RAF1, KRAS
29MAPK cascadeGO:0001658.1NF1, MAP2K2, MAP2K1, HRAS, RAF1, KRAS
30Ras protein signal transductionGO:0072658.0NF1, MAP2K2, MAP2K1, HRAS, RAF1, KRAS
31fibroblast growth factor receptor signaling pathwayGO:0085437.8BRAF, MAP2K2, MAP2K1, HRAS, RAF1, KRAS
32neurotrophin TRK receptor signaling pathwayGO:0480117.8BRAF, MAP2K2, MAP2K1, HRAS, RAF1, KRAS

Molecular functions related to Pulmonic Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine kinase activator activityGO:0435399.9MAP2K2, MAP2K1
2protein serine/threonine/tyrosine kinase activityGO:0047129.8MAP2K1, MAP2K2
3Ras GTPase bindingGO:0170169.5MAP2K1, RAF1
4MAP kinase kinase activityGO:0047089.5MAP2K1, MAP2K2
5protein serine/threonine kinase activityGO:0046748.7RAF1, MAP2K1, MAP2K2, BRAF
6protein bindingGO:0055155.4ELN, DTNA, ZIC3, BRAF, NF1, IGFBP7

Products for genes affiliated with Pulmonic Stenosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonic Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet