Aliases & Classifications for Pulmonic Stenosis

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Aliases & Descriptions for Pulmonic Stenosis:

Name: Pulmonic Stenosis 42
Valvular Pulmonic Stenosis 42
 
Pulmonary Valve Stenosis 61
Pulmonary Stenosis 61


Classifications:



Summaries for Pulmonic Stenosis

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Wikipedia:64 Pulmonic stenosis, also known as pulmonary stenosis, is a dynamic or fixed obstruction of flow from the... more...

MalaCards based summary: Pulmonic Stenosis, also known as valvular pulmonic stenosis, is related to leopard syndrome 1 and noonan syndrome 1, and has symptoms including pulmonic stenosis An important gene associated with Pulmonic Stenosis is IGFBP7 (insulin-like growth factor binding protein 7), and among its related pathways are Development Leptin signaling via JAK STAT and MAPK cascades and Development FGFR signaling pathway. The drug alprostadil and the compounds trifluoroethanol and gppnhp have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Related Diseases for Pulmonic Stenosis

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Diseases related to Pulmonic Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1leopard syndrome 130.9PTPN11
2noonan syndrome 130.9PTPN11
3congenital heart disease30.7JAG1, PTPN11
4pulmonary valve stenosis30.4ELN, JAG1, PTPN11
5cardiofaciocutaneous syndrome30.0HRAS, BRAF, PTPN11
6leopard syndrome30.0RAF1, HRAS, PTPN11
7sarcoma29.8BRAF, RAF1, HRAS
8mental retardation29.7HRAS, ELN, BRAF, PTPN11
9costello syndrome29.5HRAS, ELN, BRAF, PTPN11
10ventricular septal defect10.7
11tetralogy of fallot10.6
12retinal arterial macroaneurysm with supravalvular pulmonic stenosis10.5
13mediastinitis10.5
14aneurysm10.5
15pulmonary hypertension10.4
16patent ductus arteriosus10.4
17watson syndrome10.4
18keutel syndrome10.3
19congestive heart failure10.3
20pulmonary subvalvular stenosis10.3
21patent foramen ovale10.3
22heterotaxy, visceral, 1, x-linked10.2
23leukemia, juvenile myelomonocytic10.1HRAS, PTPN11
24noonan syndrome 610.1
25noonan syndrome 810.1
26peters anomaly10.1
27noonan syndrome 410.1
28pitt-hopkins-like syndrome 210.1
29mowat-wilson syndrome10.1
30adams-oliver syndrome 110.1
31trichohepatoenteric syndrome 110.1
32williams-beuren syndrome10.1
33charge syndrome10.1
34noonan syndrome 710.1
35ventricular septal defect 110.1
36mungan syndrome10.1
37chondrosarcoma10.1
38ritscher-schinzel syndrome10.1
39nephronophthisis 1610.1
40muscular dystrophy-dystroglycanopathy , type a, 410.1
41adams-oliver syndrome 510.1
42hypermethioninemia due to adenosine kinase deficiency10.1
43spondyloepiphyseal dysplasia with congenital joint dislocations10.1
44noonan syndrome 310.1
45marfan syndrome10.1
46microphthalmia, syndromic 910.1
47neurofibromatosis-noonan syndrome10.1
48koolen-de vries syndrome10.1
49right atrial isomerism10.1
50hypercalcemia, infantile10.1

Graphical network of the top 20 diseases related to Pulmonic Stenosis:



Diseases related to pulmonic stenosis

Symptoms for Pulmonic Stenosis

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HPO human phenotypes related to Pulmonic Stenosis:

id Description Frequency HPO Source Accession
1 pulmonic stenosis HP:0001642

Drugs & Therapeutics for Pulmonic Stenosis

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Drug clinical trials:

Search ClinicalTrials for Pulmonic Stenosis

Search NIH Clinical Center for Pulmonic Stenosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Pulmonic Stenosis

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Anatomical Context for Pulmonic Stenosis

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MalaCards organs/tissues related to Pulmonic Stenosis:

31
Heart, Liver, Lung, B cells

Animal Models for Pulmonic Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Pulmonic Stenosis:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.3JAG1, PTPN11, IGFBP7, HRAS, RAF1
2MP:00053708.0RAF1, JAG1, PTPN11, BRAF
3MP:00020068.0HRAS, RAF1, PTPN11, BRAF
4MP:00053697.8RAF1, PTPN11, ELN, BRAF, JAG1
5MP:00053827.8HRAS, RAF1, BRAF, JAG1, PTPN11
6MP:00053917.8RAF1, JAG1, BRAF, PTPN11
7MP:00107717.8RAF1, PTPN11, BRAF, JAG1, HRAS
8MP:00053887.8HRAS, RAF1, PTPN11, ELN, BRAF
9MP:00028737.7RAF1, BRAF, PTPN11, JAG1, HRAS
10MP:00036317.6PTPN11, BRAF, JAG1, HRAS, RAF1
11MP:00053907.4HRAS, PTPN11, BRAF, JAG1, ELN, RAF1
12MP:00053857.4BRAF, ELN, JAG1, PTPN11, HRAS, RAF1
13MP:00053767.2RAF1, ELN, JAG1, BRAF, HRAS, PTPN11
14MP:00107687.2ELN, BRAF, PTPN11, HRAS, RAF1, JAG1

Publications for Pulmonic Stenosis

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Articles related to Pulmonic Stenosis:

(show top 50)    (show all 329)
idTitleAuthorsYear
1
Prevalence of patent foramen ovale with right-to-left shunting in dogs with pulmonic stenosis. (22151278)
2012
2
Massive dilatation of the pulmonary artery in association with pulmonic stenosis and pulmonary hypertension. (22837867)
2012
3
The relevance of echocardiography heart measures for breeding against the risk of subaortic and pulmonic stenosis in Boxer dogs. (21908643)
2012
4
Addition of color Doppler to the routine obstetric sonographic survey aids in the detection of pulmonic stenosis. (20720393)
2010
5
Partial anomalous pulmonary venous return presenting as pseudo-pulmonic stenosis. (19083893)
2007
6
Balloon valvuloplasty of valvular pulmonic stenosis in the dog. (16180401)
2005
7
ECG of the month. Pulmonic stenosis. (15154725)
2004
8
Pulmonic stenosis in dogs: balloon dilation improves clinical outcome. (15515581)
2004
9
Branchio-oculo-facial syndrome with valvular pulmonic stenosis. (15591681)
2004
10
Pathogenesis of single right coronary artery and pulmonic stenosis in English Bulldogs. (11300591)
2001
11
Pulmonic stenosis caused by single coronary artery in dogs: four cases (1965-1984). (2295544)
1990
12
Management of neonatal critical pulmonic stenosis in the balloon valvotomy era. (2306149)
1990
13
Pannus formation in a Hancock-valved conduit resulting in proximal intraconduit obstruction: late complication of Rastelli procedure for complete transposition of the great vessels with ventricular septal defect and pulmonic stenosis. (7234666)
1981
14
Congenital subvalvular pulmonic stenosis in a cat. (7190749)
1980
15
Frequency and direction of interatrial shunting in valvular pulmonic stenosis with intact ventricular septum and without left ventricular inflow or outflow obstruction. An analysis of 127 patients treated by valvulotomy. (7352396)
1980
16
Double-outlet right ventricle (S,D,D), VSD related to pulmonary artery, and pulmonic stenosis absent. Correction with an intraventricular conduit in infancy. (875443)
1977
17
Combined tricuspid and pulmonic stenosis. Clinical, echocardiographic, hemodynamic, surgical, and pathological features. (559886)
1977
18
USE OF AN EXTRACARDIAC CONDUIT IN THE REPAIR OF l-TRANSPOSITION WITH l-LOOPING ASSOCIATED WITH SEVERE SUBVALVULAR PULMONIC STENOSIS AND A VENTRICULAR SEPTAL DEFECT. (15216089)
1977
19
A patch-graft technique for correction of pulmonic stenosis in dogs. (789311)
1976
20
Giant blood cyst and congenital pulmonic stenosis. Report of a case. (1190181)
1975
21
Hypercyanotic spells (cyanotic crisis) in an infant with valvar pulmonic stenosis. (4768120)
1973
22
Pulmonic stenosis in the adult. Long-term follow-up results. (5082217)
1972
23
Myocardial infarction and pulmonic stenosis in a dog. (5105715)
1971
24
Pulmonary regurgitation with ventricular septal defect and pulmonic stenosis--tetralogy of Fallot variant. (5769310)
1969
25
Dilatation of the aorta and pulmonary artery with aortic and pulmonary insufficiency in the presence of a ventricular septal defect and infundibular pulmonic stenosis. Report of a case of forme fruste of the Marfan syndrome. (5923672)
1966
26
EFFECT OF CHRONICALLY INCREASED VENTRICULAR PRESSURE ON ELECTRICAL FORCES OF THE HEART. A CORRELATION BETWEEN HEMODYNAMIC AND VECTROCARDIOGRAPHIC DATA (FRANK SYSTEM) IN 90 PATIENTS WITH AORTIC OR PULMONIC STENOSIS. (14211813)
1964
27
THE FATE OF THE PATIENT WITH PULMONIC STENOSIS. (14211817)
1964
28
CONGENITAL PULMONIC STENOSIS COMPLICATING EBSTEIN'S ANOMALY OF THE TRICUSPID VALVE. (14222416)
1964
29
LEFT SUPERIOR VENA CAVA WITH ANOMALOUS INFERIOR VENA CAVA. REPORT OF A CASE WITH ASSOCIATED ATRIAL SEPTAL DEFECT AND PULMONIC STENOSIS, SUCCESSFULLY CORRECTED. (14056243)
1963
30
Calcific pulmonic stenosis. (13938996)
1963
31
Combined aortic and pulmonic stenosis. (14477792)
1962
32
Acquired pulmonic stenosis. Report of a case caused by mediastinal neoplasm. (13965836)
1962
33
An electrographic study of right ventricular hypertrophy in pulmonic stenosis. (13606054)
1959
34
Valvular pulmonic stenosis: ausculatory and phonocardiographic characteristics. (13594834)
1958
35
Dynamics of valvular pulmonic stenosis studied by needle puncture of pulmonary artery and right ventricle on the operating table. (13525307)
1958
36
Relative pulmonic stenosis. (13402715)
1957
37
Functional changes during high output failure produced by daily hemorrhage in dogs with pulmonic stenosis. (13447182)
1957
38
Experience in the surgical management of atrial septal defect and pulmonic stenosis under hypothermia. (13403184)
1957
39
Experiences in the surgical alleviation of congenital pulmonic stenosis. (14380099)
1955
40
Clinical and hemodynamic studies of congenital pulmonic stenosis with intact ventricular septum. (13171388)
1954
41
Hemodynamic effects of valvulotomy in pulmonic stenosis. (13082668)
1953
42
The problem of isolated valvular versus infundibular pulmonic stenosis with particular reference to cardiac catheterization data and records obtained at the time of operation. (13014127)
1953
43
The surgical treatment of pure pulmonic stenosis; a description of and expansible valvulotomy. (14855226)
1951
44
Aortic vascular rings encountered in the surgical treatment of congenital pulmonic stenosis. (15410299)
1950
45
Roentgenographic changes in pulmonic stenosis; a report of 9 cases. (15419338)
1950
46
The surgical treatment of congenital pulmonic stenosis. (20342447)
1947
47
The technique of creation of an artificial ductus arteriosus in the treatment of pulmonic stenosis. (20242212)
1947
48
The Blalock operation for congenital pulmonic stenosis; report of two successful cases. (20284738)
1947
49
The surgical treatment of congenital pulmonic stenosis. (21000853)
1946
50
Anesthesia in the surgical treatment of congenital pulmonic stenosis. (20996692)
1946

Variations for Pulmonic Stenosis

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Expression for genes affiliated with Pulmonic Stenosis

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Search GEO for disease gene expression data for Pulmonic Stenosis.

Pathways for genes affiliated with Pulmonic Stenosis

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Pathways related to Pulmonic Stenosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.8RAF1, PTPN11, HRAS
2
Show member pathways
Development Flt3 signaling59
8.8HRAS, PTPN11, RAF1
38.8HRAS, RAF1, PTPN11
4
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
8.8RAF1, HRAS, PTPN11
5
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
8.8HRAS, RAF1, PTPN11
6
Show member pathways
Immune response IL 3 activation and signaling pathway59
8.8PTPN11, HRAS, RAF1
78.8HRAS, RAF1, PTPN11
88.8PTPN11, HRAS, RAF1
98.8RAF1, HRAS, PTPN11
10
Show member pathways
8.8HRAS, PTPN11, RAF1
11
Show member pathways
8.8HRAS, RAF1, PTPN11
128.8PTPN11, RAF1, HRAS
13
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.8PTPN11, RAF1, HRAS
148.8PTPN11, RAF1, HRAS
158.8PTPN11, RAF1, HRAS
168.8PTPN11, RAF1, HRAS
17
Show member pathways
IL-2 Signaling pathway36
8.8PTPN11, RAF1, HRAS
18
Show member pathways
8.6BRAF, HRAS, RAF1
19
Show member pathways
8.6BRAF, RAF1, HRAS
20
Show member pathways
Signal transduction PTEN pathway59
8.6HRAS, RAF1, BRAF
218.6BRAF, RAF1, HRAS
22
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.6RAF1, BRAF, HRAS
238.6HRAS, RAF1, BRAF
24
Show member pathways
8.6RAF1, HRAS, BRAF
25
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.6HRAS, BRAF, RAF1
26
Show member pathways
8.6BRAF, HRAS, RAF1
27
Show member pathways
Development Beta adrenergic receptors regulation of ERK59
G protein signaling G Protein alpha s signaling cascades59
G protein signaling G Protein beta gamma signaling cascades59
8.6HRAS, RAF1, BRAF
28
Show member pathways
RAC1 signaling pathway36
8.6HRAS, RAF1, BRAF
29
Show member pathways
8.6BRAF, RAF1, HRAS
308.6BRAF, HRAS, RAF1
31
Show member pathways
8.6BRAF, HRAS, RAF1
328.6BRAF, RAF1, HRAS
338.6BRAF, RAF1, HRAS
34
Show member pathways
8.5BRAF, RAF1, PTPN11
358.2HRAS, IGFBP7, RAF1, BRAF
36
Show member pathways
8.2BRAF, ELN, RAF1, HRAS
37
Show member pathways
8.2RAF1, HRAS, ELN, BRAF
38
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
8.0BRAF, RAF1, HRAS, PTPN11
398.0HRAS, RAF1, BRAF, PTPN11
40
Show member pathways
8.0HRAS, BRAF, PTPN11, RAF1
41
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway36
8.0BRAF, RAF1, HRAS, PTPN11
42
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
8.0HRAS, RAF1, BRAF, PTPN11
43
Show member pathways
8.0PTPN11, BRAF, RAF1, HRAS
44
Show member pathways
8.0RAF1, BRAF, HRAS, PTPN11
45
Show member pathways
8.0PTPN11, BRAF, HRAS, RAF1
46
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.0BRAF, RAF1, PTPN11, HRAS
478.0HRAS, PTPN11, RAF1, BRAF
48
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.0BRAF, PTPN11, RAF1, HRAS
49
Show member pathways
Immune response CD16 signaling in NK cells59
8.0HRAS, PTPN11, RAF1, BRAF
507.6RAF1, HRAS, PTPN11, JAG1, BRAF

Compounds for genes affiliated with Pulmonic Stenosis

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Compounds related to Pulmonic Stenosis according to GeneCards Suite gene sharing:

(show all 50)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol44 1110.8ELN, HRAS
2gppnhp449.8HRAS, RAF1
3phosphorothioate449.8RAF1, HRAS
4manumycin449.7RAF1, HRAS
5l-779,450609.6BRAF, RAF1
6gdc 0879609.6RAF1, BRAF
7sb 590885609.6RAF1, BRAF
8gw 5074609.6RAF1, BRAF
9gw-5074449.5BRAF, RAF1
10zm 33637260 4410.5BRAF, RAF1
11dabrafenib50 1110.5BRAF, RAF1
12regorafenib50 1110.4BRAF, RAF1
13sodium orthovanadate44 6010.4RAF1, PTPN11
14crcs449.3BRAF, HRAS
1517-(allylamino)-17-demethoxygeldanamycin449.3RAF1, BRAF
16herbimycin a44 6010.2PTPN11, RAF1, HRAS
17phosphotyrosine449.1RAF1, HRAS, PTPN11
18sorafenib44 50 1111.1RAF1, BRAF
19depsipeptide449.1RAF1, BRAF, ELN
20genistein44 28 60 1 24 1114.0ELN, HRAS, RAF1
2112-o-tetradecanoylphorbol 13-acetate448.9HRAS, RAF1, BRAF
22imatinib44 50 1110.9RAF1, BRAF, PTPN11
23phenylalanine448.9PTPN11, BRAF, HRAS
24paclitaxel44 50 1110.8BRAF, HRAS, RAF1
25pd 98,059448.8HRAS, RAF1, BRAF
26paraffin448.8HRAS, BRAF, ELN
27sb 20358044 609.8PTPN11, BRAF, RAF1
28h2o2448.7PTPN11, ELN, RAF1, HRAS
29cysteine448.6HRAS, PTPN11, ELN, RAF1
30forskolin44 50 1110.6RAF1, BRAF, PTPN11
31valine448.6RAF1, BRAF, ELN, HRAS
32aspartate448.6ELN, RAF1, HRAS, BRAF
33gtp44 289.5BRAF, RAF1, HRAS
34arginine448.4PTPN11, HRAS, BRAF, ELN
35ly294002448.4BRAF, RAF1, PTPN11, HRAS
36wortmannin448.4RAF1, HRAS, BRAF, PTPN11
37alanine448.4BRAF, ELN, RAF1, PTPN11
38phosphoinositide448.4BRAF, RAF1, HRAS, PTPN11
39glucose448.4PTPN11, HRAS, IGFBP7, BRAF
40cisplatin44 50 60 1111.4RAF1, HRAS, PTPN11, BRAF
41oligonucleotide448.4RAF1, PTPN11, BRAF, HRAS
42phosphatidylinositol448.3PTPN11, BRAF, RAF1, HRAS
43threonine448.3PTPN11, BRAF, RAF1, HRAS
44lysine448.3PTPN11, BRAF, ELN
45estrogen448.2HRAS, RAF1, BRAF, IGFBP7, ELN
46retinoic acid44 249.2BRAF, IGFBP7, HRAS, RAF1, ELN
47rapamycin448.0BRAF, ELN, RAF1, HRAS, PTPN11
48agar447.6IGFBP7, ELN, HRAS, RAF1, BRAF, PTPN11
49vegf447.6IGFBP7, HRAS, RAF1, PTPN11, ELN, BRAF
50serine447.6RAF1, HRAS, PTPN11, ELN, IGFBP7, BRAF

GO Terms for genes affiliated with Pulmonic Stenosis

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Biological processes related to Pulmonic Stenosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1inner ear developmentGO:00488399.5IGFBP7, PTPN11
2positive regulation of peptidyl-serine phosphorylationGO:00331389.1RAF1, BRAF
3cell proliferationGO:00082839.0HRAS, RAF1, ELN
4insulin receptor signaling pathwayGO:00082869.0PTPN11, RAF1, HRAS
5Fc-epsilon receptor signaling pathwayGO:00380959.0HRAS, RAF1, PTPN11
6epidermal growth factor receptor signaling pathwayGO:00071739.0PTPN11, RAF1, HRAS
7negative regulation of cell proliferationGO:00082859.0HRAS, RAF1, IGFBP7
8axon guidanceGO:00074118.9PTPN11, RAF1, HRAS
9organ morphogenesisGO:00098878.9HRAS, ELN, BRAF
10activation of MAPKK activityGO:00001868.9BRAF, RAF1, HRAS
11small GTPase mediated signal transductionGO:00072648.8HRAS, RAF1, BRAF
12synaptic transmissionGO:00072688.3HRAS, RAF1, BRAF
13fibroblast growth factor receptor signaling pathwayGO:00085438.3HRAS, RAF1, BRAF, PTPN11
14neurotrophin TRK receptor signaling pathwayGO:00480118.3HRAS, RAF1, BRAF, PTPN11

Molecular functions related to Pulmonic Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:00047099.1RAF1, BRAF
2small GTPase bindingGO:00312679.0RAF1, BRAF
3mitogen-activated protein kinase kinase bindingGO:00314348.8RAF1, BRAF
4protein bindingGO:00055156.7HRAS, IGFBP7, PTPN11, BRAF, JAG1, ELN

Sources for Pulmonic Stenosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet