MCID: PLP001
MIFTS: 50

Pulpitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

MalaCards integrated aliases for Pulpitis:

Name: Pulpitis 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD10 32 K04.0
ICD9CM 34 522.0
MeSH 41 D011671
NCIt 46 C52595
UMLS 69 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and gingivitis. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and trigeminal ganglion, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 periapical periodontitis 32.0 DSPP IL1B
2 gingivitis 29.9 CXCL8 IL1B IL6 TNF
3 contact dermatitis 29.7 CXCL8 IL1B IL6 TNF
4 periodontitis 29.6 CXCL8 IL1B IL6 MMP1 TNF
5 bone inflammation disease 28.5 CXCL8 IL1B IL6 MMP1 TNF TRPV1
6 episodic pain syndrome, familial, 1 10.6
7 polyposis, gastric 10.5 IL1B TNF
8 peptic esophagitis 10.5 CXCL8 IL1B
9 tungiasis 10.5 CXCL8 TNF
10 staphylococcal toxic shock syndrome 10.5 IL1B TNF
11 acute transverse myelitis 10.4 CXCL8 IL6
12 vulvar vestibulitis syndrome 10.4 IL1B TNF
13 burns 10.4 IL1B TNF
14 opisthorchiasis 10.4 CXCL8 IL1B
15 scorpion envenomation 10.4 IL6 TNF
16 denture stomatitis 10.4 CXCL8 IL6
17 papillary conjunctivitis 10.4 CXCL8 IL6
18 trichuriasis 10.4 CXCL8 TNF
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
20 critical limb ischemia 10.4 IL6 TNF
21 cerebral artery occlusion 10.4 IL1B TNF
22 null-cell leukemia 10.4 IL6 TNF
23 euthyroid sick syndrome 10.4 IL1B IL6
24 retinitis pigmentosa 55 10.4 IL6 TNF
25 clonorchiasis 10.4 CXCL8 TNF
26 retinitis pigmentosa 60 10.4 IL1B TNF
27 glossitis 10.3 IL6 TNF
28 ascaris lumbricoides infection 10.3 IL1B IL6
29 sapho syndrome 10.3 CXCL8 IL18
30 acute monoblastic leukemia 10.3 CXCL8 IL6
31 schnitzler syndrome 10.3 IL18 IL1B
32 actinic prurigo 10.3 IL1B TNF
33 anterior uveitis 10.3 IL6 TNF
34 haemophilus influenzae 10.3 CXCL8 IL1B TNF
35 crohn's colitis 10.3 CXCL8 IL1B TNF
36 irritant dermatitis 10.3 IL1B TNF
37 aseptic meningitis 10.3 CXCL8 IL1B TNF
38 recurrent corneal erosion 10.3 CXCL8 IL1B IL6
39 bagassosis 10.3 CXCL8 IL1B IL6
40 middle ear disease 10.3 CXCL8 IL1B TNF
41 funisitis 10.3 CXCL8 IL1B IL6
42 capillary leak syndrome 10.3 CXCL8 IL6
43 vaginitis 10.3 CXCL8 IL1B IL6
44 peptic ulcer disease 10.3 CXCL8 IL1B TNF
45 silicosis 10.3 CXCL8 IL1B TNF
46 posterior urethral valves 10.3 IL6 TNF
47 pulmonary edema 10.3 CXCL8 IL1B TNF
48 atrophic gastritis 10.3 CXCL8 IL1B TNF
49 allergic contact dermatitis 10.3 CXCL8 IL1B TNF
50 duodenal ulcer 10.3 CXCL8 IL1B TNF

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

MGI Mouse Phenotypes related to Pulpitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 IL6 SCN8A TNF TRPV1 ASH1L IL18
2 growth/size/body region MP:0005378 9.76 IL6 KNG1 SCN8A TNF TRPV1 ASH1L
3 adipose tissue MP:0005375 9.72 IL6 TNF TRPV1 ASH1L IL18
4 integument MP:0010771 9.43 IL6 TNF TRPV1 ASH1L IL18 IL1B
5 neoplasm MP:0002006 9.02 IL6 MMP1 TNF TRPV1 IL1B

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
4
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
5
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
8
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
9
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
10
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
11
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282242 5282241
12
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Early Phase 1 50-02-2 5743
14
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
15
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
16
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
17
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 105143 16682734
18 Anesthetics Phase 4,Phase 2,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
20 Epinephryl borate Phase 4,Phase 3,Phase 2
21 Anti-Infective Agents Phase 4,Phase 2
22 Adrenergic Agents Phase 4,Phase 3,Phase 2
23 Adrenergic Agonists Phase 4,Phase 3,Phase 2
24 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
25 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
26 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
27 Analgesics, Opioid Phase 4,Phase 2,Phase 1
28 Anesthetics, Local Phase 4,Phase 3,Phase 2
29 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Bronchodilator Agents Phase 4,Phase 3,Phase 2
32 Mydriatics Phase 4,Phase 3,Phase 2
33 Narcotics Phase 4,Phase 2,Phase 1
34 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
35 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Respiratory System Agents Phase 4,Phase 3,Phase 2
37 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
38 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
39 Carticaine Phase 4,Phase 3,Phase 2
40 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
41 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
42 Antiemetics Phase 4,Phase 3,Early Phase 1
43 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
44 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Early Phase 1
45 Gastrointestinal Agents Phase 4,Phase 3,Early Phase 1
46 glucocorticoids Phase 4,Phase 3,Early Phase 1
47 Hormone Antagonists Phase 4,Phase 3,Early Phase 1
48 Hormones Phase 4,Phase 3,Early Phase 1
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Early Phase 1
50 Methylprednisolone acetate Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 89)

# Name Status NCT ID Phase Drugs
1 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
4 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
5 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
6 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
7 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
8 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
9 Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block Completed NCT01546090 Phase 4 Alprazolam;placebo
10 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
11 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
12 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
13 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
14 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
15 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
16 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block Completed NCT02726737 Phase 3 sodium bicarbonate;Lidocaine;sterile distilled water
17 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
18 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
19 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
20 Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain Recruiting NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
21 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
22 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques Recruiting NCT02601833 Phase 3
23 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
24 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
25 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
26 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
27 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
28 Reduction of Post-operative Endodontic Pain Completed NCT01480752 Phase 2 Lornoxicam;normal saline;no injection
29 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
30 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
31 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
32 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block Completed NCT02536430 Phase 2 Ketorolac Tromethamine;Placebo
33 Efficacy of Two Injection Techniques on Success Rate of Inferior Alveolar Nerve Anesthesia Completed NCT02543619 Phase 2
34 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
35 Effect of High-dose Naloxone Following Third Molar Extraction Recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
36 Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block Active, not recruiting NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
37 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
38 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
39 Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain Not yet recruiting NCT03410212 Phase 2 Ketorolac Tromethamine
40 Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques Unknown status NCT01329874
41 Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars Unknown status NCT00972556 Gray Mineral Trioxide Aggregate (GMTA);Diluted (20%) Formocresol (DFC)
42 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Unknown status NCT02681276
43 Anesthetic Efficacy of X-tip Intraosseous Injection Unknown status NCT01214369
44 Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis Completed NCT02422823 Articaine;Articaine;Epinephrine
45 Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis Completed NCT01561183
46 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280
47 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo Completed NCT03116672 one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
48 Effect of Buffered Numbing Solution on Patients With Toothaches Completed NCT01868776 buffered lidocaine;nonbuffered lidocaine
49 Study of Pain Following Removal of Wisdom Teeth With Acute Pulpitis Completed NCT01153152
50 Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation Completed NCT02169102

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

38
Bone, Testes, Trigeminal Ganglion, Monocytes

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 322)
# Title Authors Year
1
Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis. ( 29397003 )
2018
2
Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal anaesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial. ( 29374995 )
2018
3
Effect of chronic stress on capsaicin-induced dental nociception in a model of pulpitis in rats. ( 29073563 )
2018
4
The Effect of Photobiomodulation on the Depth of Anesthesia During Endodontic Treatment of Teeth With Symptomatic Irreversible Pulpitis (Double Blind Randomized Clinical Trial). ( 29399304 )
2018
5
Effect of a Combination of Intranasal Ketorolac and Nitrous Oxide on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study. ( 29153730 )
2018
6
Efficacy of Articaine versus Lidocaine in Supplemental Infiltration for Mandibular First versus Second Molars with Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 29397214 )
2018
7
In Patients With Symptomatic Irreversible Pulpitis, Articaine is 3.6 Times More Efficacious Than Lidocaine in Achieving Anesthetic Success When Used for Supplementary Infiltration After Mandibular Block Anesthesia. ( 28501071 )
2017
8
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. ( 28279187 )
2017
9
Anesthetic Efficacy of Gow-Gates Nerve Block, Inferior Alveolar Nerve Block, and Their Combination in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Clinical Trial. ( 29273494 )
2017
10
Pulpotomy, partial pulpectomy, and total pulpectomy reduced pain and thermal and chewing sensitivity in patients with molars with irreversible pulpitis. ( 29054279 )
2017
11
2% mepivacaine seems to do better than 2%A lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis. ( 28215443 )
2017
12
Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: A systematic review of the literature and meta-analysis. ( 27834417 )
2017
13
Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 28437508 )
2017
14
Supplementary techniques for pain control during root canal treatment of lower posterior teeth with irreversible pulpitis: A systematic review and meta-analysis. ( 28736921 )
2017
15
Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. ( 27837343 )
2017
16
Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: A multi-center randomized controlled trial. ( 29178761 )
2017
17
Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. ( 28449751 )
2017
18
Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial. ( 28857203 )
2017
19
Comparison of Acupuncture with Ibuprofen for Pain Management in Patients with Symptomatic Irreversible Pulpitis: A Randomized Double-Blind Clinical Trial. ( 29275795 )
2017
20
Trigeminocardiac reflex during non-surgical root canal treatment of teeth with irreversible pulpitis. ( 28728750 )
2017
21
The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. ( 28560802 )
2017
22
Partial Pulpotomy in Mature Permanent Teeth with Clinical Signs Indicative of Irreversible Pulpitis: A Randomized Clinical Trial. ( 28673494 )
2017
23
Effect of different dental burs for experimental induction of pulpitis in mice. ( 28829993 )
2017
24
Up-regulation of TLR2 and TLR4 in high mobility group Box1-stimulated macrophages in pulpitis patients. ( 28293399 )
2017
25
Successful pulpal anesthesia for symptomatic irreversible pulpitis. ( 28190451 )
2017
26
Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. ( 29269717 )
2017
27
Efficacy of orally administered prednisolone versus partial endodontic treatment on pain reduction in emergency care of acute irreversible pulpitis of mandibular molars: study protocol for a randomized controlled trial. ( 28351379 )
2017
28
Treatment Outcomes of Full Pulpotomy as an Alternative to Tooth Extraction in Molars with Hyperplastic/Irreversible Pulpitis: A Case Report. ( 28512498 )
2017
29
Anesthetic Efficacy of Articaine and Ketamine for Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis: A Prospective Randomized Double-Blind Study. ( 29225640 )
2017
30
Combination Analgesics Reduce Postoperative Pain in Teeth With a Pulpal Diagnosis of Irreversible Pulpitis. ( 28259322 )
2017
31
The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double-blind placebo-controlled clinical trial. ( 28214370 )
2017
32
Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. ( 28776717 )
2017
33
Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis. ( 28694714 )
2017
34
Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis. ( 29042940 )
2017
35
Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis. ( 28416306 )
2017
36
MTA pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study. ( 26841969 )
2016
37
Comparative evaluation of effect of preoperative alprazolam and diclofenac potassium on the success of inferior alveolar, Vazirani-Akinosi, and Gow-Gates techniques for teeth with irreversible pulpitis: Randomized controlled trial. ( 27656053 )
2016
38
Gene expression profile of pulpitis. ( 27052691 )
2016
39
Effect of Dexamethasone Intraligamentary Injection on Post-Endodontic Pain in Patients with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial. ( 27790253 )
2016
40
A randomized placebo-blind study of the effect of low power laser on pain caused by irreversible pulpitis. ( 27696017 )
2016
41
Antibiotic use for irreversible pulpitis. ( 26886473 )
2016
42
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells. ( 26775677 )
2016
43
Irreversible pulpitis and achieving profound anesthesia: Complexities and managements. ( 26957681 )
2016
44
Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block inA Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study. ( 27507627 )
2016
45
Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. ( 26952243 )
2016
46
Effect of Oral Premedication on the Efficacy of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. ( 27042580 )
2016
47
Efficacy of Ketorolac Buccal Infiltrations and Inferior Alveolar Nerve Blocks in Patients with Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial. ( 26964901 )
2016
48
Anesthetic Success of an Inferior Alveolar Nerve Block and Supplemental Articaine Buccal Infiltration for Molars and Premolars in Patients with Symptomatic Irreversible Pulpitis. ( 26831048 )
2016
49
How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis? ( 27663614 )
2016
50
Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial. ( 27994420 )
2016

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 CXCL8 IL18 IL1B IL6 MMP1 TNF
2
Show member pathways
12.9 CXCL8 IL18 IL1B IL6 TNF
3
Show member pathways
12.76 CXCL8 IL1B IL6 TNF
4
Show member pathways
12.75 CXCL8 IL18 IL1B IL6 TNF
5
Show member pathways
12.67 CXCL8 IL18 IL1B IL6 TNF
6
Show member pathways
12.54 IL18 IL1B IL6 TNF
7
Show member pathways
12.53 IL18 IL1B IL6 TNF
8
Show member pathways
12.48 CXCL8 IL1B IL6 TNF
9
Show member pathways
12.24 CXCL8 IL1B IL6 MMP1 TNF
10
Show member pathways
12.23 CXCL8 IL1B IL6 TNF
11 12.2 IL18 IL1B IL6 TNF
12
Show member pathways
12.17 CXCL8 IL6 TNF
13
Show member pathways
12.15 CXCL8 IL1B IL6 TNF
14 12.14 CXCL8 IL1B IL6 TNF
15 12.11 IL6 MMP1 TNF
16
Show member pathways
12.06 CXCL8 IL18 IL1B IL6 TNF
17 11.97 CXCL8 IL1B IL6 TNF
18 11.91 IL1B IL6 TNF
19 11.9 CXCL8 IL1B IL6
20
Show member pathways
11.89 IL18 IL1B IL6 TNF
21 11.86 IL1B IL6 TNF
22 11.86 CXCL8 IL1B IL6 TNF
23 11.84 CXCL8 IL1B TNF
24 11.84 CXCL8 IL1B IL6 TNF
25 11.77 CXCL8 IL6 MMP1
26 11.77 CXCL8 IL18 IL1B IL6
27 11.75 IL18 IL1B TNF
28 11.72 IL1B IL6 TNF
29 11.71 CXCL8 IL1B IL6 TNF
30 11.6 CXCL8 IL1B IL6 TNF
31
Show member pathways
11.57 CXCL8 IL1B IL6 MMP1 TNF
32 11.55 CXCL8 IL6 MMP1
33 11.51 IL6 KNG1 TNF
34 11.51 IL18 IL1B TNF
35 11.49 CXCL8 IL18 IL1B IL6 MMP1 TNF
36 11.48 IL1B IL6 TNF
37 11.46 CXCL8 IL18 IL1B IL6 TNF
38 11.34 IL1B IL6 TNF
39 11.34 CXCL8 IL18 IL1B IL6 TNF
40 11.32 CXCL8 IL6 MMP1
41 11.28 IL18 IL1B IL6 TNF
42 11.27 IL1B IL6 TNF
43 11.25 IL1B IL6 TNF
44 11.24 CXCL8 IL18 IL1B IL6 TNF
45 11.21 IL18 IL1B IL6 TNF
46 11.11 IL18 IL1B
47 11.11 CXCL8 IL18 IL1B IL6 TNF
48 11.1 IL18 IL1B TNF
49 11.09 CXCL8 TNF
50 11.05 IL6 TNF

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CXCL8 IL18 IL1B IL6 KNG1 TNF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP IL18 IL1B IL6 KNG1

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 IL18 IL1B IL6 TNF
2 positive regulation of apoptotic process GO:0043065 9.91 IL6 KNG1 TNF TRPV1
3 immune response GO:0006955 9.89 CXCL8 IL18 IL1B IL6 TNF
4 regulation of receptor activity GO:0010469 9.83 CXCL8 IL18 IL1B IL6 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B IL6 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL6 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.79 IL1B IL6 TNF
8 cellular response to organic cyclic compound GO:0071407 9.73 IL18 IL1B TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 IL18 IL6 TNF
10 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
11 negative regulation of myoblast differentiation GO:0045662 9.65 IL18 TNF
12 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
13 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
14 negative regulation of lipid catabolic process GO:0050995 9.64 IL1B TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF
16 positive regulation of interleukin-6 production GO:0032755 9.63 IL1B IL6 TNF
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 IL1B TNF
19 neutrophil activation GO:0042119 9.59 CXCL8 IL18
20 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.58 IL18 IL1B
21 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
22 positive regulation of interferon-gamma production GO:0032729 9.58 IL18 IL1B TNF
23 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.55 IL1B TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IL1B TNF TRPV1
26 fever generation GO:0001660 9.52 IL1B TRPV1
27 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
28 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
29 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 IL18 IL1B TNF
30 positive regulation of NF-kappaB import into nucleus GO:0042346 9.33 IL18 IL1B TNF
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
32 inflammatory response GO:0006954 9.17 CXCL8 IL18 IL1B IL6 KNG1 TNF
33 interleukin-6 production GO:0032635 9.13 ASH1L IL18 IL1B
34 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 ASH1L IL18 IL1B IL6 TNF

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL18 IL1B IL6 TNF

Sources for Pulpitis

3 CDC
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10 dbSNP
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16 ExPASy
18 FMA
27 GO
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65 SNOMED-CT via HPO
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70 UMLS via Orphanet
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