MCID: PLP001
MIFTS: 47

Pulpitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

Aliases & Descriptions for Pulpitis:

Name: Pulpitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD10 33 K04.0
ICD9CM 35 522.0
MeSH 42 D011671
NCIt 47 C52595
UMLS 69 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and intussusception. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, trigeminal ganglion and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

Wikipedia : 71 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
id Related Disease Score Top Affiliating Genes
1 periapical periodontitis 11.2
2 intussusception 10.3 IL1B TNF
3 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
4 stocco dos santos syndrome 10.3 IL1B TNF
5 conidiobolomycosis 10.3 CXCL8 TNF
6 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.3 IL1B TNF
7 dyslexia 5 10.3 IL6 TNF
8 aortic atherosclerosis 10.3 IL6 TNF
9 degenerative disc disease 10.3 IL6 TNF
10 twin-to-twin transfusion syndrome 10.3 IL1B TNF
11 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL6
12 psychotic disorder 10.2 CXCL8 IL6
13 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
14 swine influenza 10.2 IL6 TNF
15 parkinson disease 11 10.2 CXCL8 IL1B TNF
16 oculomotor nerve paralysis 10.2 CXCL8 IL1B IL6
17 common peroneal nerve lesion 10.2 CXCL8 IL1B IL6
18 senile reticular retinal degeneration 10.2 CXCL8 IL1B TNF
19 warthin tumor 10.2 IL1B TNF
20 childhood electroclinical syndrome 10.2 CXCL8 IL1B IL6
21 carbuncle 10.2 CXCL8 IL1B IL6
22 ovarian cystic teratoma 10.2 CXCL8 IL1B TNF
23 drug dependence 10.2 IL6 TNF
24 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6 TNF
25 nasal cavity cancer 10.2 CXCL8 IL1B TNF
26 schwannoma of ureter 10.2 CXCL8 IL6
27 esophagus lymphoma 10.2 CXCL8 IL6 TNF
28 childhood central nervous system mixed germ cell tumor 10.2 CXCL8 IL1B TNF
29 skin conditions 10.2 CXCL8 IL1B TNF
30 trichomalacia 10.2 CXCL8 IL6 TNF
31 cicatricial lagophthalmos 10.2 CXCL8 IL6 TNF
32 periodontitis 10.2
33 gastric dilatation 10.2 CXCL8 IL6 TNF
34 anal paget's disease 10.2 IL1B IL6 TNF
35 bipolar i disorder 10.2 IL1B IL6 TNF
36 human immunodeficiency virus infectious disease 10.2 IL1B IL6 TNF
37 measles 10.2 IL1B IL6 TNF
38 balkan nephropathy 10.2 CXCL8 IL1B TNF
39 retinal vascular occlusion 10.2 CXCL8 IL1B TNF
40 dextrocardia 10.2 IL1B IL6 TNF
41 erb-duchenne and dejerine-klumpke palsies 10.2 CXCL8 IL6 TNF
42 unilateral hypoactive labyrinth 10.2 CXCL8 IL1B TNF
43 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B IL6 TNF
44 mikulicz disease 10.2 IL1B IL6 TNF
45 spinal multifocal clear cell meningioma 10.2 CXCL8 IL1B IL6
46 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL1B IL6 TNF
47 gonococcal endophthalmia 10.2 IL1B IL6 TNF
48 breast apocrine carcinoma in situ 10.2 CXCL8 IL1B IL6
49 mineral metabolism disease 10.2 IL1B IL6 TNF
50 migraine with aura 10.2 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

GenomeRNAi Phenotypes related to Pulpitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CXCL8 IL18 IL1B NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CXCL8 IL18 IL1B NOS2 TNF

MGI Mouse Phenotypes related to Pulpitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 IL18 IL1B IL6 NOS2 SCN8A TNF
2 adipose tissue MP:0005375 9.65 IL18 IL6 NOS2 TNF TRPV1
3 integument MP:0010771 9.43 IL18 IL1B IL6 NOS2 TNF TRPV1
4 neoplasm MP:0002006 9.1 IL1B IL6 MMP1 NOS2 TNF TRPV1

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
3
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
4
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
7
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
8
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
9
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
10
Ceftibuten Approved Phase 4 97519-39-6 5282241 5282242
11
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
13
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
14
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
15
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
16 Anesthetics Phase 4,Phase 3,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
18 Epinephryl borate Phase 4,Phase 3,Phase 2
19 Racepinephrine Phase 4,Phase 3,Phase 2
20 Anti-Infective Agents Phase 4,Phase 2
21 Adrenergic Agents Phase 4,Phase 3,Phase 2
22 Adrenergic Agonists Phase 4,Phase 3,Phase 2
23 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
24 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
25 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
26 Analgesics, Opioid Phase 4,Phase 2,Phase 1
27 Anesthetics, Local Phase 4,Phase 3,Phase 2
28 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
29 Autonomic Agents Phase 4,Phase 3,Phase 2
30 Bronchodilator Agents Phase 4,Phase 3,Phase 2
31 Mydriatics Phase 4,Phase 3,Phase 2
32 Narcotics Phase 4,Phase 2,Phase 1
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Respiratory System Agents Phase 4,Phase 3,Phase 2
36 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
37 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
38 Carticaine Phase 4,Phase 3
39 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
40 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
41 Antiemetics Phase 4,Phase 3
42 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Antineoplastic Agents, Hormonal Phase 4,Phase 3
44 Gastrointestinal Agents Phase 4,Phase 3
45 glucocorticoids Phase 4,Phase 3
46 Hormone Antagonists Phase 4,Phase 3
47 Hormones Phase 4,Phase 3
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
49 Methylprednisolone acetate Phase 4,Phase 3
50 Methylprednisolone Hemisuccinate Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 75)
id Name Status NCT ID Phase
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4
2 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4
3 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4
4 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4
5 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4
6 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4
7 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4
8 Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block Completed NCT01546090 Phase 4
9 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4
10 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
11 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Enrolling by invitation NCT02702505 Phase 4
12 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3
13 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3
14 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
15 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block Completed NCT02726737 Phase 3
16 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3
17 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3
18 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques Recruiting NCT02601833 Phase 3
19 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03146481 Phase 2, Phase 3
20 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3
21 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
22 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Not yet recruiting NCT02629042 Phase 3
23 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
24 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2
25 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2
26 Reduction of Post-operative Endodontic Pain Completed NCT01480752 Phase 2
27 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2
28 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2
29 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2
30 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block Completed NCT02536430 Phase 2
31 Efficacy of Two Injection Techniques on Success Rate of Inferior Alveolar Nerve Anesthesia Completed NCT02543619 Phase 2
32 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2
33 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2
34 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2
35 Effect of High-dose Naloxone Following Third Molar Extraction Not yet recruiting NCT02976337 Phase 2
36 Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques Unknown status NCT01329874
37 Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars Unknown status NCT00972556
38 Anesthetic Efficacy of X-tip Intraosseous Injection Unknown status NCT01214369
39 European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth Unknown status NCT01797458
40 Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis Completed NCT02422823
41 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280
42 Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis Completed NCT01561183
43 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo Completed NCT03116672
44 Effect of Buffered Numbing Solution on Patients With Toothaches Completed NCT01868776
45 Study of Pain Following Removal of Wisdom Teeth With Acute Pulpitis Completed NCT01153152
46 Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation Completed NCT02169102
47 Effect of Glass Ionomer Cement as an Interim Restoration in Diagnosis of Pulpal Status Completed NCT03168620
48 Success of Inferior Alveolar Nerve Block in Women Taking Selective Serotonin Reuptake Inhibitors Completed NCT02884596
49 Postoperative Pain Intensity After Using Different Instrumentation Techniques: a Randomized Clinical Study Completed NCT02566486
50 Occlusal Reduction and Postoperative Pain Completed NCT03117062

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

39
Testes, Trigeminal Ganglion, Monocytes, Bone

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 290)
id Title Authors Year
1
Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: A systematic review of the literature and meta-analysis. ( 27834417 )
2017
2
Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. ( 27837343 )
2017
3
A randomized placebo-blind study of the effect of low power laser on pain caused by irreversible pulpitis. ( 27696017 )
2016
4
Efficacy of Ketorolac Buccal Infiltrations and Inferior Alveolar Nerve Blocks in Patients with Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial. ( 26964901 )
2016
5
Anesthetic Success of an Inferior Alveolar Nerve Block and Supplemental Articaine Buccal Infiltration for Molars and Premolars in Patients with Symptomatic Irreversible Pulpitis. ( 26831048 )
2016
6
Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial. ( 27994420 )
2016
7
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells. ( 26775677 )
2016
8
Relationship between post-extraction pain and acute pulpitis: a randomised trial using third molars. ( 27424879 )
2016
9
Comparison of Manual and Rotary Instrumentation on Postoperative Pain in Teeth with Asymptomatic Irreversible Pulpitis: A Randomized Clinical Trial. ( 27790255 )
2016
10
Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block inA Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study. ( 27507627 )
2016
11
Comparative evaluation of effect of preoperative alprazolam and diclofenac potassium on the success of inferior alveolar, Vazirani-Akinosi, and Gow-Gates techniques for teeth with irreversible pulpitis: Randomized controlled trial. ( 27656053 )
2016
12
Efficacy of Articaine and Lidocaine for Buccal Infiltration of First Maxillary Molars with Symptomatic Irreversible Pulpitis: A Randomized Double-blinded Clinical Trial. ( 27141212 )
2016
13
ASH1L Suppresses Matrix Metalloproteinase through Mitogen-activated Protein Kinase Signaling Pathway in Pulpitis. ( 28041684 )
2016
14
Antibiotics are not useful to reduce pain associated with irreversible pulpitis. ( 27767119 )
2016
15
Comparison of the Anesthetic Efficacy ofA Mepivacaine and Lidocaine in Patients withA Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( 27475099 )
2016
16
Anesthetic Efficacy in Irreversible Pulpitis: A Randomized Clinical Trial. ( 27652697 )
2016
17
Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis. ( 27176631 )
2016
18
Antibiotic use for irreversible pulpitis. ( 26886473 )
2016
19
MTA pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study. ( 26841969 )
2016
20
Effect of Dexamethasone Intraligamentary Injection on Post-Endodontic Pain in Patients with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial. ( 27790253 )
2016
21
Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. ( 26952243 )
2016
22
Irreversible pulpitis and achieving profound anesthesia: Complexities and managements. ( 26957681 )
2016
23
Management of Chronic Hyperplastic Pulpitis in Mandibular Molars of Middle Aged Adults- A Multidisciplinary Approach. ( 26894192 )
2016
24
Gene expression profile of pulpitis. ( 27052691 )
2016
25
Efficacy of preoperative ibuprofen and meloxicam on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis. ( 27933616 )
2016
26
Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( 27769675 )
2016
27
Calcium-Enriched Mixture Pulpotomy of Primary Molar Teeth with Irreversible Pulpitis. A Clinical Study. ( 27326265 )
2016
28
Anaesthetic efficacy of intraligamentary injection techniques on mandibular molars diagnosed with asymptomatic irreversible pulpitis: A retrospective study. ( 27558847 )
2016
29
Microbiome of Deep Dentinal Caries Lesions in Teeth with Symptomatic Irreversible Pulpitis. ( 27135405 )
2016
30
Efficacy and safety of articaine versus lidocaine for irreversible pulpitis treatment: A systematic review and meta-analysis of randomised controlled trials. ( 27062318 )
2016
31
How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis? ( 27663614 )
2016
32
Effect of Oral Premedication on the Efficacy of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. ( 27042580 )
2016
33
Buffered Lidocaine With Sodium Bicarbonate did not Increase Inferior Alveolar Nerve Block Success Rate in Patients Having Symptomatic Irreversible Pulpitis. ( 27132560 )
2016
34
Randomized Clinical Trial of Intraosseous Methylprednisolone Injection for Acute Pulpitis Pain. ( 26603771 )
2016
35
Vital Pulp Therapy of a Mature Molar with Concurrent Hyperplastic Pulpitis, Internal Root Resorption and Periradicular Periodontitis: A Case Report. ( 26523145 )
2015
36
Anesthetic success of supplemental infiltration in mandibular molars with irreversible pulpitis: A systematic review. ( 26069400 )
2015
37
Comparison of Anesthetic Efficacy between Lidocaine withA and without Magnesium Sulfate USP 50% for Inferior Alveolar Nerve Blocks in Patients with Symptomatic Irreversible Pulpitis. ( 25742794 )
2015
38
Conditional TNF-I+ Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis. ( 26503912 )
2015
39
Comparison of Preoperative Oral Ketorolac on Anesthetic Efficacy of Inferior Alveolar Nerve Block and Buccal and Lingual Infiltration with Articaine and Lidocaine in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. ( 26410153 )
2015
40
Incidence of missed inferior alveolar nerve blocks in vital asymptomatic subjects and in patients with symptomatic irreversible pulpitis. ( 25770038 )
2015
41
Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to nociception induced by acute pulpitis in rats. ( 26224622 )
2015
42
Isolation and Characterization of Human Dental Pulp Stem Cells from Cryopreserved Pulp Tissues Obtained from Teeth with Irreversible Pulpitis. ( 26577871 )
2015
43
Anaesthetic Efficacy of Topical Benzocaine Gel Combined with Hyaluronidase for Supplemental Intrapulpal Injection in Teeth with Irreversible Pulpitis- A Double Blinded Clinical Trial. ( 26436058 )
2015
44
Immune Cells and Molecular Networks in Experimentally Induced Pulpitis. ( 26472753 )
2015
45
Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. ( 25944414 )
2015
46
A Comparison of Different Volumes of Articaine for Inferior Alveolar Nerve Block for Molar Teeth with Symptomatic Irreversible Pulpitis. ( 26149210 )
2015
47
A Combination of Acetaminophen/Hydrocodone may not Affect Cold Pulpal Testing in Patients With Symptomatic Irreversible Pulpitis. ( 25987386 )
2015
48
Does Articaine Provide an Advantage over Lidocaine in Patients with Symptomatic Irreversible Pulpitis? A Systematic Review and Meta-analysis. ( 26293174 )
2015
49
Three Incomplete Caries Removal Techniques Compared Over Two Years in Primary Molars with Asymptomatic Deep Caries or Reversible Pulpitis. ( 26531075 )
2015
50
Dynamic Regulation of Delta-Opioid Receptor in Rat Trigeminal Ganglion Neurons by Lipopolysaccharide-induced Acute Pulpitis. ( 26515439 )
2015

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CXCL8 IL18 IL1B IL6 MMP1 NOS2
2
Show member pathways
12.94 CXCL8 IL18 IL1B IL6 NOS2 TNF
3
Show member pathways
12.86 CXCL8 IL1B IL6 NOS2 TNF
4
Show member pathways
12.77 CXCL8 IL18 IL1B IL6 TNF
5
Show member pathways
12.76 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.71 CXCL8 IL18 IL1B IL6 TNF
7 12.61 CXCL8 IL6 MMP1 NOS2
8
Show member pathways
12.56 IL18 IL1B IL6 NOS2 TNF
9
Show member pathways
12.54 IL18 IL1B IL6 TNF
10
Show member pathways
12.33 CXCL8 IL1B IL6 MMP1 TNF
11
Show member pathways
12.26 CXCL8 IL1B IL6 NOS2 TNF
12 12.23 IL18 IL1B IL6 NOS2 TNF
13 12.18 IL6 MMP1 NOS2 TNF
14 12.17 CXCL8 IL1B IL6 TNF
15
Show member pathways
12.17 CXCL8 IL1B IL6 NOS2 TNF
16
Show member pathways
12.13 CXCL8 IL18 IL1B IL6 TNF
17 11.97 CXCL8 IL1B IL6 NOS2 TNF
18
Show member pathways
11.95 IL18 IL1B IL6 TNF
19
Show member pathways
11.94 IL18 IL1B NOS2
20 11.92 IL1B IL6 TNF
21 11.91 CXCL8 IL1B IL6
22 11.91 CXCL8 IL1B IL6 TNF
23 11.86 IL1B IL6 TNF
24 11.85 CXCL8 IL1B TNF
25 11.84 CXCL8 IL1B IL6 NOS2 TNF
26 11.79 CXCL8 IL6 MMP1
27 11.77 IL18 IL1B TNF
28 11.77 CXCL8 IL18 IL1B IL6 NOS2
29 11.75 IL1B IL6 TNF
30 11.7 IL6 NOS2 TNF
31 11.69 CXCL8 IL1B IL6 TNF
32 11.68 CXCL8 IL1B IL6 NOS2 TNF
33 11.6 CXCL8 IL6 NOS2
34 11.59 CXCL8 IL18 IL1B IL6 MMP1 TNF
35 11.56 CXCL8 IL6 MMP1 NOS2
36 11.53 IL6 KNG1 TNF
37 11.52 IL18 IL1B NOS2 TNF
38 11.51 CXCL8 IL18 IL1B IL6 TNF
39 11.5 IL1B IL6 TNF
40 11.41 CXCL8 IL18 IL1B IL6 TNF
41 11.37 IL1B IL6 TNF
42 11.36 CXCL8 IL6 MMP1
43 11.36 IL18 IL1B IL6 TNF
44 11.34 CXCL8 IL18 IL1B IL6 TNF
45 11.31 IL1B IL6 TNF
46 11.29 IL1B IL6 TNF
47 11.28 IL18 IL1B IL6 TNF
48
Show member pathways
11.23 CXCL8 IL1B IL6 MMP1 NOS2 TNF
49 11.22 CXCL8 IL18 IL1B IL6 MMP1 NOS2
50 11.21 CXCL8 IL18 IL1B IL6 TNF

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CXCL8 IL18 IL1B IL6 KNG1 TNF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP IL18 IL1B IL6 KNG1

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.91 IL6 KNG1 TNF TRPV1
2 immune response GO:0006955 9.89 CXCL8 IL18 IL1B IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
4 cellular response to tumor necrosis factor GO:0071356 9.8 CXCL8 IL6 TRPV1
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
6 positive regulation of protein kinase B signaling GO:0051897 9.76 IL18 IL6 TNF
7 cellular response to organic cyclic compound GO:0071407 9.74 IL18 IL1B TNF
8 regulation of insulin secretion GO:0050796 9.72 IL1B NOS2 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 IL18 IL6 TNF
10 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
11 negative regulation of myoblast differentiation GO:0045662 9.66 IL18 TNF
12 embryonic digestive tract development GO:0048566 9.65 CXCL8 TNF
13 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
14 positive regulation of chemokine production GO:0032722 9.64 IL6 TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.63 IL1B TNF
17 positive regulation of interferon-gamma production GO:0032729 9.63 IL18 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
19 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
20 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TNF
21 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.6 IL18 IL1B
22 negative regulation of lipid storage GO:0010888 9.59 IL6 TNF
23 positive regulation of T-helper 2 cell differentiation GO:0045630 9.58 IL18 IL6
24 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNF
25 cellular response to lipopolysaccharide GO:0071222 9.56 CXCL8 IL6 NOS2 TNF
26 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.54 IL6 TNF
27 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 IL18 IL1B TNF
29 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
31 fever generation GO:0001660 9.37 IL1B TRPV1
32 positive regulation of NF-kappaB import into nucleus GO:0042346 9.33 IL18 IL1B TNF
33 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 IL1B IL6 TNF TRPV1
34 inflammatory response GO:0006954 9.17 CXCL8 IL18 IL1B IL6 KNG1 TNF

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL18 IL1B IL6 TNF

Sources for Pulpitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....