MCID: PLP001
MIFTS: 45

Pulpitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

MalaCards integrated aliases for Pulpitis:

Name: Pulpitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD10 33 K04.0
ICD9CM 35 522.0
MeSH 42 D011671
NCIt 47 C52595
UMLS 69 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and tabatznik syndrome. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and trigeminal ganglion, and related phenotypes are cardiovascular system and neoplasm

Wikipedia : 72 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
id Related Disease Score Top Affiliating Genes
1 periapical periodontitis 11.2
2 tabatznik syndrome 10.7 IL1B TNF
3 basidiobolomycosis 10.7 CXCL8 TNF
4 sternal cleft 10.7 IL1B TNF
5 lacrimal apparatus disease 10.7 CXCL8 IL1B
6 smarca4-deficient sarcoma of thorax 10.7 IL6 TNF
7 drug rash with eosinophilia and systemic symptoms 10.7 CXCL8 IL6
8 walker dyson syndrome 10.7 IL1B TNF
9 aortic arch interruption 10.7 IL6 TNF
10 cataract 10.7 IL1B TNF
11 cutaneous leishmaniasis 10.7 IL6 TNF
12 schwannoma of ureter 10.7 CXCL8 IL6
13 psychotic disorder 10.7 CXCL8 IL6
14 tarsal tunnel syndrome 10.7 CXCL8 TNF
15 chancroid 10.6 CXCL8 IL1B
16 halal setton wang syndrome 10.6 CXCL8 TNF
17 toxoplasmosis 10.6 IL6 TNF
18 dyslexia 5 10.6 IL6 TNF
19 epstein-barr virus hepatitis 10.6 IL6 TNF
20 x-linked dominant intellectual disability-epilepsy syndrome 10.6 IL1B IL6
21 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.6 IL1B TNF
22 anencephaly and spina bifida x-linked 10.6 IL6 TNF
23 plantar wart 10.6 CXCL8 TNF
24 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
25 papilledema 10.6 IL6 TNF
26 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
27 low compliance bladder 10.6 NOS2 TNF
28 congenital nonspherocytic hemolytic anemia 10.6 IL1B IL6
29 acute myeloblastic leukemia without maturation 10.6 CXCL8 IL6
30 moved to 244450 10.6 IL1B TNF
31 lung sarcoma 10.6 IL1B TNF
32 spondylocostal dysostosis 4 10.5 CD163 TNF
33 idiopathic dilatation of the pulmonary artery 10.5 NOS2 TNF
34 potato nose 10.5 IL6 TNF
35 labyrinthine bilateral reactive loss 10.5 CXCL8 IL6
36 senile reticular retinal degeneration 10.5 CXCL8 IL1B TNF
37 oculomotor nerve paralysis 10.5 CXCL8 IL1B IL6
38 common peroneal nerve lesion 10.5 CXCL8 IL1B IL6
39 testicular infarct 10.5 CXCL8 IL1B TNF
40 mycobacterium kansasii 10.5 CXCL8 TNF
41 infancy electroclinical syndrome 10.5 CXCL8 IL1B IL6
42 tibialis tendinitis 10.5 CXCL8 IL1B TNF
43 carbuncle 10.5 CXCL8 IL1B IL6
44 extrahepatic bile duct papillary adenoma 10.5 CXCL8 IL1B TNF
45 spirillary rat-bite fever 10.5 CXCL8 IL6 TNF
46 sinusitis 10.5 CXCL8 IL1B TNF
47 pyelonephritis 10.5 CXCL8 IL1B TNF
48 pasteurellosis 10.5 CXCL8 IL6 TNF
49 plantar fascial fibromatosis 10.5 CXCL8 IL1B TNF
50 churg-strauss syndrome 10.5 CXCL8 IL1B TNF

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

MGI Mouse Phenotypes related to Pulpitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CD163 IL1B IL6 NOS2 SCN8A TNF
2 neoplasm MP:0002006 9.1 IL1B IL6 MMP1 NOS2 TNF TRPV1

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
4
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
5
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
8
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
9
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
10
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
11
Ceftibuten Approved Phase 4 97519-39-6 5282241 5282242
12
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Early Phase 1 50-02-2 5743
14
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
15
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
16
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
17 Anesthetics Phase 4,Phase 3,Phase 2
18 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
19 Epinephryl borate Phase 4,Phase 3,Phase 2
20 Anti-Infective Agents Phase 4,Phase 2
21 Adrenergic Agents Phase 4,Phase 3,Phase 2
22 Adrenergic Agonists Phase 4,Phase 3,Phase 2
23 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
24 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
25 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
26 Analgesics, Opioid Phase 4,Phase 2,Phase 1
27 Anesthetics, Local Phase 4,Phase 3,Phase 2
28 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
29 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
30 Bronchodilator Agents Phase 4,Phase 3,Phase 2
31 Mydriatics Phase 4,Phase 3,Phase 2
32 Narcotics Phase 4,Phase 2,Phase 1
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Respiratory System Agents Phase 4,Phase 3,Phase 2
36 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
37 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
38 Carticaine Phase 4,Phase 3,Phase 2
39 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
40 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
41 Antiemetics Phase 4,Phase 3,Early Phase 1
42 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Early Phase 1
44 Gastrointestinal Agents Phase 4,Phase 3,Early Phase 1
45 glucocorticoids Phase 4,Phase 3,Early Phase 1
46 Hormone Antagonists Phase 4,Phase 3,Early Phase 1
47 Hormones Phase 4,Phase 3,Early Phase 1
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Early Phase 1
49 Methylprednisolone acetate Phase 4,Phase 3
50 Methylprednisolone Hemisuccinate Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 82)

id Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
3 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
4 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
5 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
6 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 Articaine local anesthetic;Lidocaine local anesthetic
7 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
8 Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block Completed NCT01546090 Phase 4 Alprazolam;placebo
9 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
10 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
11 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Enrolling by invitation NCT02702505 Phase 4
12 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
13 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
14 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
15 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block Completed NCT02726737 Phase 3 sodium bicarbonate;Lidocaine;sterile distilled water
16 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
17 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
18 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
19 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques Recruiting NCT02601833 Phase 3
20 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03146481 Phase 2, Phase 3 Aceclofenac
21 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
22 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
23 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
24 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
25 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
26 Reduction of Post-operative Endodontic Pain Completed NCT01480752 Phase 2 Lornoxicam;normal saline;no injection
27 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
28 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
29 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
30 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block Completed NCT02536430 Phase 2 Ketorolac Tromethamine;Placebo
31 Efficacy of Two Injection Techniques on Success Rate of Inferior Alveolar Nerve Anesthesia Completed NCT02543619 Phase 2
32 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
33 Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block Active, not recruiting NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
34 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
35 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
36 Effect of High-dose Naloxone Following Third Molar Extraction Not yet recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
37 Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques Unknown status NCT01329874
38 Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars Unknown status NCT00972556 Gray Mineral Trioxide Aggregate (GMTA);Diluted (20%) Formocresol (DFC)
39 Anesthetic Efficacy of X-tip Intraosseous Injection Unknown status NCT01214369
40 Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis Completed NCT02422823 Articaine;Articaine;Epinephrine
41 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280
42 Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis Completed NCT01561183
43 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo Completed NCT03116672 one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
44 Effect of Buffered Numbing Solution on Patients With Toothaches Completed NCT01868776 buffered lidocaine;nonbuffered lidocaine
45 Study of Pain Following Removal of Wisdom Teeth With Acute Pulpitis Completed NCT01153152
46 Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation Completed NCT02169102
47 Effect of Glass Ionomer Cement as an Interim Restoration in Diagnosis of Pulpal Status Completed NCT03168620
48 Success of Inferior Alveolar Nerve Block in Women Taking Selective Serotonin Reuptake Inhibitors Completed NCT02884596 selective serotonin reuptake inhibitor
49 Postoperative Pain Intensity After Using Different Instrumentation Techniques: a Randomized Clinical Study Completed NCT02566486
50 Occlusal Reduction and Postoperative Pain Completed NCT03117062

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

39
Bone, Testes, Trigeminal Ganglion, Monocytes

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 310)
id Title Authors Year
1
Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis. ( 28416306 )
2017
2
The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double-blind placebo-controlled clinical trial. ( 28214370 )
2017
3
Up-regulation of TLR2 and TLR4 in high mobility group Box1-stimulated macrophages in pulpitis patients. ( 28293399 )
2017
4
In Patients With Symptomatic Irreversible Pulpitis, Articaine is 3.6 Times More Efficacious Than Lidocaine in Achieving Anesthetic Success When Used for Supplementary Infiltration After Mandibular Block Anesthesia. ( 28501071 )
2017
5
Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 28437508 )
2017
6
Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. ( 27837343 )
2017
7
2% mepivacaine seems to do better than 2%A lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis. ( 28215443 )
2017
8
Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: A systematic review of the literature and meta-analysis. ( 27834417 )
2017
9
Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. ( 28449751 )
2017
10
Trigeminocardiac reflex during non-surgical root canal treatment of teeth with irreversible pulpitis. ( 28728750 )
2017
11
Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. ( 28776717 )
2017
12
Successful pulpal anesthesia for symptomatic irreversible pulpitis. ( 28190451 )
2017
13
Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis. ( 28694714 )
2017
14
Partial Pulpotomy in Mature Permanent Teeth with Clinical Signs Indicative of Irreversible Pulpitis: A Randomized Clinical Trial. ( 28673494 )
2017
15
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. ( 28279187 )
2017
16
Effect of different dental burs for experimental induction of pulpitis in mice. ( 28829993 )
2017
17
Supplementary techniques for pain control during root canal treatment of lower posterior teeth with irreversible pulpitis: A systematic review and meta-analysis. ( 28736921 )
2017
18
The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. ( 28560802 )
2017
19
Combination Analgesics Reduce Postoperative Pain in Teeth With a Pulpal Diagnosis of Irreversible Pulpitis. ( 28259322 )
2017
20
Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial. ( 28857203 )
2017
21
Treatment Outcomes of Full Pulpotomy as an Alternative to Tooth Extraction in Molars with Hyperplastic/Irreversible Pulpitis: A Case Report. ( 28512498 )
2017
22
Efficacy of orally administered prednisolone versus partial endodontic treatment on pain reduction in emergency care of acute irreversible pulpitis of mandibular molars: study protocol for a randomized controlled trial. ( 28351379 )
2017
23
Comparison of the Anesthetic Efficacy ofA Mepivacaine and Lidocaine in Patients withA Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( 27475099 )
2016
24
Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( 27769675 )
2016
25
Microbiome of Deep Dentinal Caries Lesions in Teeth with Symptomatic Irreversible Pulpitis. ( 27135405 )
2016
26
Buffered Lidocaine With Sodium Bicarbonate did not Increase Inferior Alveolar Nerve Block Success Rate in Patients Having Symptomatic Irreversible Pulpitis. ( 27132560 )
2016
27
Efficacy of Articaine and Lidocaine for Buccal Infiltration of First Maxillary Molars with Symptomatic Irreversible Pulpitis: A Randomized Double-blinded Clinical Trial. ( 27141212 )
2016
28
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells. ( 26775677 )
2016
29
Efficacy of Ketorolac Buccal Infiltrations and Inferior Alveolar Nerve Blocks in Patients with Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial. ( 26964901 )
2016
30
How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis? ( 27663614 )
2016
31
Calcium-Enriched Mixture Pulpotomy of Primary Molar Teeth with Irreversible Pulpitis. A Clinical Study. ( 27326265 )
2016
32
Antibiotics are not useful to reduce pain associated with irreversible pulpitis. ( 27767119 )
2016
33
Irreversible pulpitis and achieving profound anesthesia: Complexities and managements. ( 26957681 )
2016
34
Anesthetic Success of an Inferior Alveolar Nerve Block and Supplemental Articaine Buccal Infiltration for Molars and Premolars in Patients with Symptomatic Irreversible Pulpitis. ( 26831048 )
2016
35
Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis. ( 27176631 )
2016
36
Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial. ( 27994420 )
2016
37
A randomized placebo-blind study of the effect of low power laser on pain caused by irreversible pulpitis. ( 27696017 )
2016
38
Randomized Clinical Trial of Intraosseous Methylprednisolone Injection for Acute Pulpitis Pain. ( 26603771 )
2016
39
Comparative evaluation of effect of preoperative alprazolam and diclofenac potassium on the success of inferior alveolar, Vazirani-Akinosi, and Gow-Gates techniques for teeth with irreversible pulpitis: Randomized controlled trial. ( 27656053 )
2016
40
Efficacy and safety of articaine versus lidocaine for irreversible pulpitis treatment: A systematic review and meta-analysis of randomised controlled trials. ( 27062318 )
2016
41
Efficacy of preoperative ibuprofen and meloxicam on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis. ( 27933616 )
2016
42
Anesthetic Efficacy in Irreversible Pulpitis: A Randomized Clinical Trial. ( 27652697 )
2016
43
Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. ( 26952243 )
2016
44
Management of Chronic Hyperplastic Pulpitis in Mandibular Molars of Middle Aged Adults- A Multidisciplinary Approach. ( 26894192 )
2016
45
Relationship between post-extraction pain and acute pulpitis: a randomised trial using third molars. ( 27424879 )
2016
46
Effect of Dexamethasone Intraligamentary Injection on Post-Endodontic Pain in Patients with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial. ( 27790253 )
2016
47
Anaesthetic efficacy of intraligamentary injection techniques on mandibular molars diagnosed with asymptomatic irreversible pulpitis: A retrospective study. ( 27558847 )
2016
48
Comparison of Manual and Rotary Instrumentation on Postoperative Pain in Teeth with Asymptomatic Irreversible Pulpitis: A Randomized Clinical Trial. ( 27790255 )
2016
49
ASH1L Suppresses Matrix Metalloproteinase through Mitogen-activated Protein Kinase Signaling Pathway in Pulpitis. ( 28041684 )
2016
50
Gene expression profile of pulpitis. ( 27052691 )
2016

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CXCL8 IL1B IL6 MMP1 NOS2 TNF
2
Show member pathways
12.91 CXCL8 IL1B IL6 NOS2 TNF
3
Show member pathways
12.82 CXCL8 IL1B IL6 NOS2 TNF
4
Show member pathways
12.76 CXCL8 IL1B IL6 TNF
5
Show member pathways
12.7 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.65 CXCL8 IL1B IL6 TNF
7 12.6 CXCL8 IL6 MMP1 NOS2
8
Show member pathways
12.52 IL1B IL6 NOS2 TNF
9
Show member pathways
12.27 CXCL8 IL1B IL6 MMP1 TNF
10 12.19 IL1B IL6 NOS2 TNF
11
Show member pathways
12.19 CXCL8 IL1B IL6 NOS2 TNF
12
Show member pathways
12.17 IL1B NOS2 TNF
13 12.15 IL6 MMP1 NOS2 TNF
14 12.14 CXCL8 IL1B IL6 TNF
15
Show member pathways
12.09 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.09 CXCL8 IL1B IL6 NOS2 TNF
17 11.94 CD163 IL6 TNF
18 11.9 IL1B IL6 TNF
19 11.89 CXCL8 IL1B IL6
20
Show member pathways
11.89 IL1B IL6 TNF
21 11.87 CXCL8 IL1B IL6 TNF
22 11.85 CXCL8 IL1B IL6 NOS2 TNF
23 11.84 IL1B IL6 TNF
24 11.83 CXCL8 IL1B TNF
25 11.79 CXCL8 IL1B IL6 NOS2
26 11.76 CXCL8 IL6 MMP1
27 11.73 CD163 IL1B IL6 TNF
28 11.7 CXCL8 IL1B IL6 NOS2 TNF
29 11.69 IL6 NOS2 TNF
30 11.62 CXCL8 IL1B IL6 TNF
31 11.61 CXCL8 IL1B IL6 MMP1 TNF
32 11.58 CXCL8 IL6 NOS2
33 11.55 CXCL8 IL1B IL6 TNF
34 11.52 IL6 KNG1 TNF
35 11.51 IL1B NOS2 TNF
36 11.49 CXCL8 IL1B IL6 MMP1 NOS2 TNF
37 11.48 IL1B IL6 TNF
38 11.47 CXCL8 IL6 MMP1 NOS2
39 11.43 CXCL8 IL1B IL6 NOS2 TNF
40 11.42 CXCL8 IL1B IL6 TNF
41 11.4 CXCL8 IL1B IL6 TNF
42 11.34 IL1B IL6 TNF
43 11.34 IL1B IL6 TNF
44 11.32 CXCL8 IL6 MMP1
45 11.29 IL1B IL6 TNF
46 11.27 IL1B IL6 TNF
47 11.24 IL1B IL6 TNF
48 11.18 CXCL8 IL1B IL6 TNF
49 11.09 CXCL8 TNF
50 11.05 IL1B TNF

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CD163 IL6 TNF TRPV1
2 extracellular region GO:0005576 9.23 CD163 CXCL8 DSPP IL1B IL6 KNG1

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL8 IL1B IL6 TNF
2 positive regulation of apoptotic process GO:0043065 9.85 IL6 KNG1 TNF TRPV1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 IL1B IL6 TNF
4 cellular response to tumor necrosis factor GO:0071356 9.75 CXCL8 IL6 TRPV1
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.73 IL1B IL6 TNF
6 regulation of insulin secretion GO:0050796 9.65 IL1B NOS2 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.63 IL1B TNF
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL1B TNF
9 embryonic digestive tract development GO:0048566 9.61 CXCL8 TNF
10 negative regulation of lipid catabolic process GO:0050995 9.6 IL1B TNF
11 positive regulation of chemokine production GO:0032722 9.59 IL6 TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IL1B TNF
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.57 IL1B TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL1B TNF
15 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
16 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.5 IL1B IL6 TNF
18 regulation of establishment of endothelial barrier GO:1903140 9.49 IL1B TNF
19 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.46 IL6 TNF
20 cellular response to lipopolysaccharide GO:0071222 9.46 CXCL8 IL6 NOS2 TNF
21 fever generation GO:0001660 9.43 IL1B TRPV1
22 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
23 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 IL1B IL6 TNF TRPV1
26 inflammatory response GO:0006954 9.17 CD163 CXCL8 IL1B IL6 KNG1 TNF

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL1B IL6 TNF

Sources for Pulpitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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