MCID: PNC059
MIFTS: 27

Punctate Inner Choroidopathy malady

Category: Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

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Aliases & Descriptions for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 46 66
 
Pic 46

Classifications:



Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:46 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as pic, is related to panuveitis and choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways are Tuberculosis and SIDS Susceptibility Pathways. Affiliated tissues include eye.

Related Diseases for Punctate Inner Choroidopathy

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Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1panuveitis30.8IL10, TNF
2choroiditis10.9
3multifocal choroiditis10.7
4retinitis10.3
5acute zonal occult outer retinopathy10.3
6neuroretinitis10.1
7histoplasmosis10.1
8neuropathy10.1
9central serous chorioretinopathy10.1
1012p12.1 microdeletion syndrome10.1IL10, TNF
11piepkorn karp hickok syndrome10.1IL10, TNF
126q terminal deletion syndrome10.1IL10, TNF
13basidiobolomycosis10.1IL10, TNF
14paralytic lagophthalmos10.1IL10, TNF
15multiple carboxylase deficiency, propionic acidemia10.1IL10, TNF
16graft-versus-host disease, protection against10.1IL10, TNF
17fallopian tube endometriosis10.1IL10, TNF
18ethmoid sinus adenoid cystic carcinoma10.1IL10, TNF
19neurotic excoriation10.1IL10, TNF
20addison's disease10.1IL10, TNF
21primary orthostatic tremor10.1IL10, TNF
22peripheral t-cell lymphoma10.1IL10, TNF
23hernia of ovary and fallopian tube10.1IL10, TNF
24lipodermatosclerosis10.1IL10, TNF
25burns10.1IL10, TNF
26papillary transitional carcinoma10.1IL10, TNF
27meninges hemangiopericytoma10.1IL10, TNF
28orbital lymphangioma10.1IL10, TNF
29cauda equina syndrome10.1IL10, TNF
30pseudoretinitis pigmentosa10.1IL10, TNF
31pneumonic tularemia10.1IL10, TNF
32idiopathic central precocious puberty10.1IL10, TNF
33alkhurma hemorrhagic fever10.1IL10, TNF
34sensorineural hearing loss10.1IL10, TNF
35peanut allergy10.1IL10, TNF
36scn8a encephalopathy10.1IL10, TNF
37psychologic dyspareunia10.1IL10, TNF
38mastocytosis cutaneous with short stature conductive hearing loss and microtia10.1IL10, TNF
39hemophagocytic lymphohistiocytosis10.1IL10, TNF
40primary biliary cirrhosis10.1IL10, TNF
41leukostasis10.1IL10, TNF
42allergic hypersensitivity disease10.0IL10, TNF
43paratyphoid fever10.0IL10, TNF
44accessory nerve disease10.0IL10, TNF
45senile cataract10.0IL10, TNF
46dementia - subcortical10.0IL10, TNF
47hypospadias10.0IL10, TNF
48oesophagostomiasis10.0IL10, TNF
49bartonellosis10.0IL10, TNF
50binocular vision disease10.0IL10, TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMDWithdrawnNCT01256580

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

34
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. (27555066)
2016
2
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. (25687028)
2015
3
Punctate inner choroidopathy in systemic lupus. (25648066)
2015
4
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. (26421890)
2015
5
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. (26955337)
2015
6
Punctate inner choroidopathy: a systematic review. (25741523)
2014
7
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
8
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. (25370399)
2014
9
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. (25046400)
2014
10
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy. (24885365)
2014
11
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
12
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
13
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
14
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
15
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
16
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
17
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
18
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
19
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
20
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
21
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
22
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
23
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
24
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
25
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
26
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
27
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
28
Punctate inner choroidopathy. (21056447)
2011
29
Punctate inner choroidopathy: clinical features and outcomes. (20696997)
2010
30
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
31
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
32
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
33
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
34
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
35
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
36
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
37
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
38
Photodynamic therapy for subfoveal and juxtafoveal choroidal neovascularization associated with punctate inner choroidopathy. (17365803)
2007
39
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
40
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
41
Acute zonal occult outer retinopathy in the fellow eye 5 years after presentation of punctate inner choroidopathy. (16315044)
2006
42
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
43
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
44
Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. (12812908)
2003
45
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
46
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
47
Indocyanine green angiographic findings in a case of punctate inner choroidopathy. (9793776)
1998
48
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
49
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
50
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.1IL10, TNF
29.1IL10, TNF
3
Show member pathways
9.1IL10, TNF
49.1IL10, TNF
59.1IL10, TNF
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
89.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
10
Show member pathways
9.1IL10, TNF
119.1IL10, TNF
12
Show member pathways
9.1IL10, TNF
139.1IL10, TNF
149.1IL10, TNF
159.1IL10, TNF
169.1IL10, TNF
179.1IL10, TNF
189.1IL10, TNF
199.1IL10, TNF
209.1IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:00328009.7IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
3positive regulation of cytokine secretionGO:00507159.6IL10, TNF
4negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
5response to glucocorticoidGO:00513849.6IL10, TNF
6negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
7cellular response to lipopolysaccharideGO:00712229.6IL10, TNF
8defense response to bacteriumGO:00427429.2IL10, TNF
9response to organic substanceGO:00100339.1IL10, TNF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL10, TNF

Sources for Punctate Inner Choroidopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet