MCID: PNC059
MIFTS: 27

Punctate Inner Choroidopathy malady

Rare diseases category

Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:41 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as pic, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are Allograft rejection and B Cell Receptor Signaling Pathway. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

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Punctate Inner Choroidopathy, Aliases & Descriptions:

Name: Punctate Inner Choroidopathy 41 60
 
Pic 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Punctate Inner Choroidopathy

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Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Drug clinical trials:

Search ClinicalTrials for Punctate Inner Choroidopathy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

31
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. (25687028)
2015
2
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. (25631844)
2015
3
Punctate inner choroidopathy in systemic lupus. (25648066)
2015
4
Punctate inner choroidopathy: a systematic review. (25741523)
2014
5
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
6
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. (25370399)
2014
7
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. (25046400)
2014
8
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
9
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
10
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
11
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
12
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
13
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
14
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
15
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
16
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
17
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
18
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
19
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. (25389949)
2012
20
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
21
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
22
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
23
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
24
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
25
Punctate inner choroidopathy. (21056447)
2011
26
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
27
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
28
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
29
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
30
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
31
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
32
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
33
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
34
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
35
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
36
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
37
Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. (17237756)
2008
38
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
39
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
40
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
41
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
42
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
43
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
44
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
45
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
46
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
47
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
48
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
2
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1TNF, IL10
39.1IL10, TNF
4
Show member pathways
9.1IL10, TNF
5
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1TNF, IL10
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
11
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.1IL10, TNF
129.1IL10, TNF
139.1TNF, IL10
14
Show member pathways
9.1IL10, TNF
159.1IL10, TNF
169.1TNF, IL10
179.1TNF, IL10
189.1IL10, TNF
19
Show member pathways
IL27-mediated signaling events36
9.1IL10, TNF
209.1IL10, TNF

Compounds for genes affiliated with Punctate Inner Choroidopathy

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Compounds related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cdp571439.6IL10, TNF
2interferon gamma439.6IL10, TNF
3gabexate mesilate439.6TNF, IL10
4blys439.6TNF, IL10
5toxin-1439.6IL10, TNF
6ulinastatin439.6IL10, TNF
7mip 1alpha439.6TNF, IL10
8natalizumab43 1210.6IL10, TNF
95 aminosalicylic acid439.6TNF, IL10
10il-12439.6TNF, IL10
11adalimumab43 49 1211.6IL10, TNF
12indoleamine439.6IL10, TNF
13imiquimod43 59 28 1212.6TNF, IL10
14cyclosporine49 1210.5IL10, TNF
15polymyxin b439.5IL10, TNF
16groalpha439.5TNF, IL10
17okt3439.5TNF, IL10
18gm-csf43 2810.5IL10, TNF
19lipoteichoic acid439.5TNF, IL10
208-isoprostane439.5IL10, TNF
212,5-oligoadenylate439.5TNF, IL10
22polyinosinic-polycytidylic acid439.5TNF, IL10
23rolipram43 59 2811.5IL10, TNF
24etanercept43 49 1211.5IL10, TNF
25il 10439.5TNF, IL10
26mycophenolate mofetil43 49 1211.5TNF, IL10
27infliximab43 49 1211.5IL10, TNF
28tarc439.5IL10, TNF
29peptidoglycan43 2810.5TNF, IL10
30ivig439.5IL10, TNF
31ccl343 2810.5TNF, IL10
32pentoxifylline43 1210.5TNF, IL10
33neopterin439.5IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2439.4IL10, TNF
35rituximab43 49 1211.4TNF, IL10
36thalidomide43 49 59 1212.4IL10, TNF
37chloroquine43 2 49 28 1213.4IL10, TNF
38atorvastatin43 49 28 24 1213.4TNF, IL10
39prednisolone43 28 1211.4TNF, IL10
40hydrocortisone43 2 59 1212.4IL10, TNF
41tgf beta1439.4IL10, TNF
42simvastatin43 49 59 28 24 1214.3TNF, IL10
43endotoxin439.3IL10, TNF
44ionomycin439.3IL10, TNF
45prostacyclin439.2TNF, IL10
46tacrolimus43 49 1211.2IL10, TNF
47calcitriol43 59 24 1212.1IL10, TNF
48sb 20358043 5910.1IL10, TNF
49methotrexate49 43 1211.0TNF, IL10
50rantes438.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:00328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:00027409.4IL10, TNF
3negative regulation of growth of symbiont in hostGO:00441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:00327159.3IL10, TNF
5positive regulation of cytokine secretionGO:00507159.3IL10, TNF
6response to activityGO:00148239.2TNF, IL10
7response to glucocorticoidGO:00513849.2IL10, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1IL10, TNF
9positive regulation of transcription, DNA-templatedGO:00458939.1IL10, TNF
10response to drugGO:00424939.0TNF, IL10
11inflammatory responseGO:00069548.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

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3CDC
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22GTR
23HGMD
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25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
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34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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46OMIM via Orphanet
50PubMed
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56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet