PIC
MCID: PNC059
MIFTS: 20

Punctate Inner Choroidopathy (PIC) malady

Summaries for Punctate Inner Choroidopathy

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are SIDS Susceptibility Pathways and Development PDGF signaling via STATs and NF-kB. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder.

Aliases & Classifications for Punctate Inner Choroidopathy

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

punctate inner choroidopathy 43 61
pic 43


Related Diseases for Punctate Inner Choroidopathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis10.9
2multifocal choroiditis10.8
3acute zonal occult outer retinopathy10.5
4n syndrome10.4
5central serous chorioretinopathy10.4
6vesicoureteral reflux10.2
7cryoglobulinemia10.0
8acute pyelonephritis10.0
9neonatal meningitis10.0
10pneumococcal meningitis10.0
11blau syndrome10.0TNF
12aids dementia complex10.0TNF
13toxic shock syndrome10.0TNF
14chorioamnionitis10.0TNF
15arthropathy10.0TNF
16familial mediterranean fever10.0TNF
17respiratory failure10.0TNF
18interstitial lung disease10.0TNF
19psoriatic arthritis10.0TNF
20periodontal disease10.0TNF
21ankylosing spondylitis10.0TNF
22paracoccidioidomycosis10.0IL10
23common variable immune deficiency10.0IL10
24vasculitis10.0TNF
25schistosomiasis10.0IL10
26tetanus10.0IL10
27myasthenia gravis10.0IL10
28lupus nephritis10.0IL10
29atopy10.0IL10
30leishmaniasis10.0IL10
31acute pancreatitis10.0IL10
32allergic rhinitis10.0IL10
33sarcoidosis10.0TNF
34alcoholic hepatitis10.0IL10, TNF
35acute graft versus host disease10.0TNF, IL10
36cerebral malaria10.0TNF, IL10
37periodontitis10.0IL10, TNF
38graft versus host disease10.0TNF, IL10
39septic shock10.0IL10, TNF
40hepatitis c10.0TNF, IL10
41congenital heart defect10.0TNF, IL10
42atopic dermatitis10.0IL10, TNF
43hypersensitivity reaction type ii disease10.0IL10, TNF
44cork-handlers' disease10.0TNF, IL10
45skin disease10.0TNF, IL10
46connective tissue disease10.0IL10, TNF
47uveitis10.0IL10, TNF
48ulcerative colitis10.0IL10, TNF
49sepsis10.0TNF, IL10
50inflammatory bowel disease10.0TNF, IL10

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Clinical Features for Punctate Inner Choroidopathy

Drugs & Therapeutics for Punctate Inner Choroidopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Punctate Inner Choroidopathy

Anatomical Context for Punctate Inner Choroidopathy

Animal Models for Punctate Inner Choroidopathy or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Punctate Inner Choroidopathy

Genetic Variations for Punctate Inner Choroidopathy

Expression for genes affiliated with Punctate Inner Choroidopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 53R&D Systems
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Compounds for genes affiliated with Punctate Inner Choroidopathy

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1cdp571459.6IL10, TNF
2interferon gamma459.6IL10, TNF
3blys459.6TNF, IL10
4toxin-1459.6IL10, TNF
5mip 1alpha459.5IL10, TNF
6natalizumab45 1110.5TNF, IL10
7adalimumab45 50 1111.5IL10, TNF
8il-12459.5TNF, IL10
95 aminosalicylic acid459.5TNF, IL10
10indoleamine459.5IL10, TNF
11imiquimod45 29 60 1112.5TNF, IL10
12polymyxin b459.5IL10, TNF
13groalpha459.5TNF, IL10
14okt3459.5TNF, IL10
15gm-csf45 2910.5IL10, TNF
16lipoteichoic acid459.5TNF, IL10
178-isoprostane459.5IL10, TNF
18polyinosinic-polycytidylic acid459.5TNF, IL10
192,5-oligoadenylate459.5TNF, IL10
20etanercept45 50 1111.5IL10, TNF
21il 10459.5TNF, IL10
22infliximab45 50 1111.5IL10, TNF
23tarc459.5IL10, TNF
24peptidoglycan45 2910.5TNF, IL10
25ivig459.4IL10, TNF
26ccl345 2910.4TNF, IL10
27neopterin459.4IL10, TNF
28rituximab45 50 1111.4IL10, TNF
2915-deoxy-delta-12,14-prostaglandin j2459.4TNF, IL10
30thalidomide45 50 60 1112.4IL10, TNF
31chloroquine45 2 50 29 1113.4TNF, IL10
32atorvastatin45 50 29 11 2413.4IL10, TNF
33tgf beta1459.3IL10, TNF
34simvastatin45 50 60 29 11 2414.3TNF, IL10
35ionomycin459.3IL10, TNF
36prostacyclin459.2TNF, IL10
37tacrolimus45 50 1111.2IL10, TNF
38calcitriol45 60 11 2412.1IL10, TNF
39sb 20358045 6010.1IL10, TNF
40methotrexate45 50 1111.0TNF, IL10
41rantes458.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

Sources:
16Gene Ontology
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Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.3IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
5response to activityGO:0148239.2IL10, TNF
6positive regulation of cytokine secretionGO:0507159.2TNF, IL10
7response to glucocorticoid stimulusGO:0513849.1IL10, TNF
8inflammatory responseGO:0069549.1IL10, TNF
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL10, TNF
10response to drugGO:0424938.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet