MCID: PNC059
MIFTS: 32

Punctate Inner Choroidopathy malady

Rare diseases category

Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:43 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as pic, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are Allograft rejection and B Cell Receptor Signaling Pathway. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

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Punctate Inner Choroidopathy, Aliases & Descriptions:

Name: Punctate Inner Choroidopathy 43 62
 
Pic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Punctate Inner Choroidopathy

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Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis11.2
2multifocal choroiditis10.9
3panuveitis10.7
4neuroretinitis10.4
5histoplasmosis10.4
6neuropathy10.4
7retinitis10.4
8acute zonal occult outer retinopathy10.4
9central serous chorioretinopathy10.4
10blindness10.4
11blau syndrome10.0TNF
12leishmaniasis10.0IL10
13alcoholic hepatitis10.0IL10, TNF
14acute graft versus host disease10.0TNF, IL10
15demyelinating disease10.0TNF, IL10
16periodontitis10.0TNF, IL10
17graft-versus-host disease, protection against10.0TNF, IL10
18uveitis10.0IL10, TNF
19connective tissue disease10.0IL10, TNF
20liver disease10.0IL10, TNF
21hepatitis c10.0IL10, TNF
22colitis10.0TNF, IL10
23congenital heart disease10.0IL10, TNF
24atopic dermatitis10.0IL10, TNF
25cork-handlers' disease10.0TNF, IL10
26skin disease10.0IL10, TNF
27pneumonia10.0IL10, TNF
28vascular disease10.0TNF, IL10
29congenital human immunodeficiency virus10.0IL10, TNF
30ulcerative colitis10.0IL10, TNF
31inflammatory bowel disease10.0IL10, TNF
32malaria10.0IL10, TNF
33tuberculosis10.0TNF, IL10
34systemic lupus erythematosus10.0TNF, IL10
35psoriasis10.0IL10, TNF
36multiple sclerosis, disease progression, modifier of10.0IL10, TNF
37arthritis10.0TNF, IL10
38hypersensitivity reaction type ii disease10.0IL10, TNF
39viral infectious disease10.0IL10, TNF
40asthma10.0TNF, IL10
41rheumatoid arthritis10.0IL10, TNF
42atherosclerosis10.0IL10, TNF
43ipex syndrome10.0IL10, TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Drug clinical trials:

Search ClinicalTrials for Punctate Inner Choroidopathy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

33
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. (25687028)
2015
2
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. (25631844)
2015
3
Punctate inner choroidopathy in systemic lupus. (25648066)
2015
4
Punctate inner choroidopathy: a systematic review. (25741523)
2014
5
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
6
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. (25370399)
2014
7
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. (25046400)
2014
8
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
9
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
10
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
11
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
12
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
13
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
14
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
15
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
16
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
17
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
18
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
19
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. (25389949)
2012
20
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
21
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
22
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
23
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
24
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
25
Punctate inner choroidopathy. (21056447)
2011
26
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
27
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
28
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
29
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
30
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
31
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
32
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
33
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
34
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
35
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
36
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
37
Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. (17237756)
2008
38
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
39
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
40
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
41
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
42
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
43
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
44
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
45
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
46
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
47
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
48
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
2
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1TNF, IL10
39.1IL10, TNF
4
Show member pathways
9.1IL10, TNF
5
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1TNF, IL10
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
11
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL10, TNF
129.1IL10, TNF
139.1TNF, IL10
14
Show member pathways
9.1IL10, TNF
159.1IL10, TNF
169.1TNF, IL10
179.1TNF, IL10
189.1IL10, TNF
19
Show member pathways
IL27-mediated signaling events38
9.1IL10, TNF
209.1IL10, TNF

Compounds for genes affiliated with Punctate Inner Choroidopathy

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Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cdp571459.6IL10, TNF
2interferon gamma459.6IL10, TNF
3gabexate mesilate459.6TNF, IL10
4blys459.6TNF, IL10
5toxin-1459.6IL10, TNF
6ulinastatin459.6IL10, TNF
7mip 1alpha459.6TNF, IL10
8natalizumab45 1310.6IL10, TNF
95 aminosalicylic acid459.6TNF, IL10
10il-12459.6TNF, IL10
11adalimumab45 51 1311.6IL10, TNF
12indoleamine459.6IL10, TNF
13imiquimod45 61 30 1312.6TNF, IL10
14cyclosporine51 1310.5IL10, TNF
15polymyxin b459.5IL10, TNF
16groalpha459.5TNF, IL10
17okt3459.5TNF, IL10
18gm-csf45 3010.5IL10, TNF
19lipoteichoic acid459.5TNF, IL10
208-isoprostane459.5IL10, TNF
212,5-oligoadenylate459.5TNF, IL10
22polyinosinic-polycytidylic acid459.5TNF, IL10
23rolipram45 61 3011.5IL10, TNF
24etanercept45 51 1311.5IL10, TNF
25il 10459.5TNF, IL10
26mycophenolate mofetil45 51 1311.5TNF, IL10
27infliximab45 51 1311.5IL10, TNF
28tarc459.5IL10, TNF
29peptidoglycan45 3010.5TNF, IL10
30ivig459.5IL10, TNF
31ccl345 3010.5TNF, IL10
32pentoxifylline45 1310.5TNF, IL10
33neopterin459.5IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2459.4IL10, TNF
35rituximab45 51 1311.4TNF, IL10
36thalidomide45 51 61 1312.4IL10, TNF
37chloroquine45 3 51 30 1313.4IL10, TNF
38atorvastatin45 51 30 26 1313.4TNF, IL10
39prednisolone45 30 1311.4TNF, IL10
40hydrocortisone45 3 61 1312.4IL10, TNF
41tgf beta1459.4IL10, TNF
42simvastatin45 51 61 30 26 1314.3TNF, IL10
43endotoxin459.3IL10, TNF
44ionomycin459.3IL10, TNF
45prostacyclin459.2TNF, IL10
46tacrolimus45 51 1311.2IL10, TNF
47calcitriol45 61 26 1312.1IL10, TNF
48sb 20358045 6110.1IL10, TNF
49methotrexate51 45 1311.0TNF, IL10
50rantes458.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:00328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:00027409.4IL10, TNF
3negative regulation of growth of symbiont in hostGO:00441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:00327159.3IL10, TNF
5positive regulation of cytokine secretionGO:00507159.3IL10, TNF
6response to activityGO:00148239.2TNF, IL10
7response to glucocorticoidGO:00513849.2IL10, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1IL10, TNF
9positive regulation of transcription, DNA-templatedGO:00458939.1IL10, TNF
10response to drugGO:00424939.0TNF, IL10
11inflammatory responseGO:00069548.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet