PIC
MCID: PNC059
MIFTS: 27

Punctate Inner Choroidopathy (PIC) malady

Category: Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

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Aliases & Descriptions for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 48 68
 
Pic 48

Classifications:



Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:48 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include eye.

Related Diseases for Punctate Inner Choroidopathy

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Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis31.3IL10, TNF
2multifocal choroiditis10.5
3panuveitis10.4
4retinitis10.2
5acute zonal occult outer retinopathy10.2
6pyridoxal 5'-phosphate-dependent epilepsy10.1IL10, TNF
7tubular renal disease-cardiomyopathy syndrome10.1IL10, TNF
8lagophthalmos10.1IL10, TNF
9multiple vertebral anomalies unusual facies10.1IL10, TNF
10conidiobolomycosis10.1IL10, TNF
11endosalpingiosis10.1IL10, TNF
12severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.1IL10, TNF
13idiopathic hypertrophic pachymeningitis10.1IL10, TNF
14transient tic disorder10.1IL10, TNF
15vestibule of mouth cancer10.1IL10, TNF
16tarsal tunnel syndrome10.1IL10, TNF
17chronic apical periodontitis10.1IL10, TNF
18plantar wart10.1IL10, TNF
19osteodysplasty precocious of danks mayne and kozlowski10.1IL10, TNF
20parkinson disease 1110.1IL10, TNF
21cyclosporiasis10.1IL10, TNF
22hypoparathyroidism-retardation-dysmorphism syndrome10.0IL10, TNF
23congenital hypothyroidism10.0IL10, TNF
24sarcomatoid transitional cell carcinoma10.0IL10, TNF
25neurotic disorder10.0IL10, TNF
26trichomalacia10.0IL10, TNF
27phlyctenulosis10.0IL10, TNF
28senile reticular retinal degeneration10.0IL10, TNF
29conduct disorder10.0IL10, TNF
30gastric dilatation10.0IL10, TNF
31pancreatic signet ring cell adenocarcinoma10.0IL10, TNF
32pulpitis10.0IL10, TNF
33tularemia10.0IL10, TNF
34rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.0IL10, TNF
35pseudo-meigs syndrome10.0IL10, TNF
36gonococcal endophthalmia10.0IL10, TNF
37ectodermal dysplasia bartalos type10.0IL10, TNF
38primary ciliary dyskinesia10.0IL10, TNF
39cryptococcosis10.0IL10, TNF
40hereditary alpha tryptasemia syndrome10.0IL10, TNF
41hepatitis10.0IL10, TNF
42rickettsialpox10.0IL10, TNF
43autosomal recessive type iv ehlers-danlos syndrome10.0IL10, TNF
44astrocytoma10.0IL10, TNF
45bladder signet ring cell adenocarcinoma10.0IL10, TNF
46acute myeloid leukemia with recurrent genetic anomaly10.0IL10, TNF
47erb-duchenne and dejerine-klumpke palsies10.0IL10, TNF
48microcephaly10.0IL10, TNF
49abnormal retinal correspondence10.0IL10, TNF
50plummer's disease10.0IL10, TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms & Phenotypes for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMDWithdrawnNCT01256580

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

36
Eye

Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy. (27977842)
2016
2
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. (27555066)
2016
3
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. (27539089)
2016
4
Combined treatment in punctate inner choroidopathy. (27729795)
2016
5
Punctate inner choroidopathy: A review. (27751823)
2016
6
Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. (26965893)
2016
7
Punctate inner choroidopathy in systemic lupus. (25648066)
2015
8
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. (26955337)
2015
9
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. (26421890)
2015
10
The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy. (26266044)
2015
11
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. (25631844)
2015
12
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. (25687028)
2015
13
Punctate Inner Choroidopathy. (26060591)
2015
14
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. (25370399)
2014
15
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy. (24885365)
2014
16
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. (25046400)
2014
17
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. (25322466)
2014
18
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
19
Punctate inner choroidopathy: a systematic review. (25741523)
2014
20
Clinical features and incidence rate of ocular complications in punctate inner choroidopathy. (24743642)
2014
21
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
22
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
23
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
24
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
25
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
26
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. (25389949)
2012
27
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
28
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
29
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
30
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
31
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
32
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
33
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
34
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
35
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
36
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
37
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
38
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. (21772986)
2011
39
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
40
Punctate inner choroidopathy. (21056447)
2011
41
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
42
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
43
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
44
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
45
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
46
Punctate inner choroidopathy: clinical features and outcomes. (20696997)
2010
47
Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. (20379284)
2010
48
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
49
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
50
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.1IL10, TNF
2
Show member pathways
9.1IL10, TNF
39.1IL10, TNF
49.1IL10, TNF
59.1IL10, TNF
69.1IL10, TNF
79.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
10
Show member pathways
9.1IL10, TNF
119.1IL10, TNF
129.1IL10, TNF
13
Show member pathways
9.1IL10, TNF
149.1IL10, TNF
159.1IL10, TNF
169.1IL10, TNF
179.1IL10, TNF
189.1IL10, TNF
199.1IL10, TNF
209.1IL10, TNF
219.1IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipopolysaccharideGO:00712229.8IL10, TNF
2defense response to bacteriumGO:00427429.8IL10, TNF
3endothelial cell apoptotic processGO:00725779.8IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.8IL10, TNF
5negative regulation of growth of symbiont in hostGO:00441309.8IL10, TNF
6negative regulation of interleukin-6 productionGO:00327159.8IL10, TNF
7negative regulation of mitotic cell cycleGO:00459309.8IL10, TNF
8positive regulation of cytokine secretionGO:00507159.7IL10, TNF
9positive regulation of heterotypic cell-cell adhesionGO:00341169.7IL10, TNF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL10, TNF
11positive regulation of vascular smooth muscle cell proliferationGO:19047079.7IL10, TNF
12receptor biosynthetic processGO:00328009.7IL10, TNF
13response to glucocorticoidGO:00513849.7IL10, TNF
14response to organic substanceGO:00100339.1IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL10, TNF

Sources for Punctate Inner Choroidopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet