PIC
MCID: PNC059
MIFTS: 27

Punctate Inner Choroidopathy (PIC) malady

Categories: Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

Aliases & Descriptions for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 50 69
Pic 50

Classifications:



Summaries for Punctate Inner Choroidopathy

NIH Rare Diseases : 50 punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary : Punctate Inner Choroidopathy, also known as pic, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways/superpathways are NF-kappaB Signaling and T cell receptor signaling pathway. Affiliated tissues include eye.

Related Diseases for Punctate Inner Choroidopathy

Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
id Related Disease Score Top Affiliating Genes
1 choroiditis 31.3 IL10 TNF
2 multifocal choroiditis 10.5
3 panuveitis 10.4
4 retinitis 10.2
5 acute zonal occult outer retinopathy 10.2
6 pyridoxal 5'-phosphate-dependent epilepsy 10.1 IL10 TNF
7 tubular renal disease-cardiomyopathy syndrome 10.1 IL10 TNF
8 lagophthalmos 10.1 IL10 TNF
9 multiple vertebral anomalies unusual facies 10.1 IL10 TNF
10 conidiobolomycosis 10.1 IL10 TNF
11 endosalpingiosis 10.1 IL10 TNF
12 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.1 IL10 TNF
13 idiopathic hypertrophic pachymeningitis 10.1 IL10 TNF
14 transient tic disorder 10.1 IL10 TNF
15 vestibule of mouth cancer 10.1 IL10 TNF
16 tarsal tunnel syndrome 10.1 IL10 TNF
17 chronic apical periodontitis 10.1 IL10 TNF
18 plantar wart 10.1 IL10 TNF
19 osteodysplasty precocious of danks mayne and kozlowski 10.1 IL10 TNF
20 parkinson disease 11 10.1 IL10 TNF
21 cyclosporiasis 10.1 IL10 TNF
22 hypoparathyroidism-retardation-dysmorphism syndrome 10.0 IL10 TNF
23 congenital hypothyroidism 10.0 IL10 TNF
24 sarcomatoid transitional cell carcinoma 10.0 IL10 TNF
25 neurotic disorder 10.0 IL10 TNF
26 trichomalacia 10.0 IL10 TNF
27 phlyctenulosis 10.0 IL10 TNF
28 senile reticular retinal degeneration 10.0 IL10 TNF
29 conduct disorder 10.0 IL10 TNF
30 gastric dilatation 10.0 IL10 TNF
31 pancreatic signet ring cell adenocarcinoma 10.0 IL10 TNF
32 pulpitis 10.0 IL10 TNF
33 tularemia 10.0 IL10 TNF
34 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.0 IL10 TNF
35 pseudo-meigs syndrome 10.0 IL10 TNF
36 gonococcal endophthalmia 10.0 IL10 TNF
37 ectodermal dysplasia bartalos type 10.0 IL10 TNF
38 primary ciliary dyskinesia 10.0 IL10 TNF
39 cryptococcosis 10.0 IL10 TNF
40 hereditary alpha tryptasemia syndrome 10.0 IL10 TNF
41 hepatitis 10.0 IL10 TNF
42 rickettsialpox 10.0 IL10 TNF
43 autosomal recessive type iv ehlers-danlos syndrome 10.0 IL10 TNF
44 astrocytoma 10.0 IL10 TNF
45 bladder signet ring cell adenocarcinoma 10.0 IL10 TNF
46 acute myeloid leukemia with recurrent genetic anomaly 10.0 IL10 TNF
47 erb-duchenne and dejerine-klumpke palsies 10.0 IL10 TNF
48 microcephaly 10.0 IL10 TNF
49 abnormal retinal correspondence 10.0 IL10 TNF
50 plummer's disease 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to Punctate Inner Choroidopathy

Symptoms & Phenotypes for Punctate Inner Choroidopathy

Drugs & Therapeutics for Punctate Inner Choroidopathy

Interventional clinical trials:


id Name Status NCT ID Phase
1 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

Anatomical Context for Punctate Inner Choroidopathy

MalaCards organs/tissues related to Punctate Inner Choroidopathy:

39
Eye

Publications for Punctate Inner Choroidopathy

Articles related to Punctate Inner Choroidopathy:

(show top 50) (show all 74)
id Title Authors Year
1
Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy. ( 27977842 )
2016
2
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. ( 27555066 )
2016
3
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. ( 27539089 )
2016
4
Combined treatment in punctate inner choroidopathy. ( 27729795 )
2016
5
Punctate inner choroidopathy: A review. ( 27751823 )
2016
6
Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. ( 26965893 )
2016
7
Punctate inner choroidopathy in systemic lupus. ( 25648066 )
2015
8
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. ( 26955337 )
2015
9
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. ( 26421890 )
2015
10
The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy. ( 26266044 )
2015
11
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. ( 25631844 )
2015
12
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. ( 25687028 )
2015
13
Punctate Inner Choroidopathy. ( 26060591 )
2015
14
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. ( 25370399 )
2014
15
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy. ( 24885365 )
2014
16
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. ( 25046400 )
2014
17
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. ( 25322466 )
2014
18
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. ( 24856311 )
2014
19
Punctate inner choroidopathy: a systematic review. ( 25741523 )
2014
20
Clinical features and incidence rate of ocular complications in punctate inner choroidopathy. ( 24743642 )
2014
21
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. ( 23769333 )
2013
22
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. ( 23584703 )
2013
23
Punctate inner choroidopathy: a clinical case report. ( 24163685 )
2013
24
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. ( 23805787 )
2013
25
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. ( 24269388 )
2012
26
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. ( 25389949 )
2012
27
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. ( 25390960 )
2012
28
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. ( 22352824 )
2012
29
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. ( 22954947 )
2012
30
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. ( 22481479 )
2012
31
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. ( 22210152 )
2012
32
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. ( 23163572 )
2012
33
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. ( 22120962 )
2012
34
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. ( 22824619 )
2012
35
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. ( 21357402 )
2011
36
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. ( 21275596 )
2011
37
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. ( 21770809 )
2011
38
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. ( 21772986 )
2011
39
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. ( 21478811 )
2011
40
Punctate inner choroidopathy. ( 21056447 )
2011
41
Clinical features of punctate inner choroidopathy in Chinese patients. ( 21499193 )
2011
42
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. ( 21188681 )
2011
43
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. ( 21350285 )
2011
44
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. ( 20224465 )
2010
45
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. ( 20714365 )
2010
46
Punctate inner choroidopathy: clinical features and outcomes. ( 20696997 )
2010
47
Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. ( 20379284 )
2010
48
Punctate inner choroidopathy in mother and daughter. ( 21052920 )
2010
49
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. ( 18617903 )
2009
50
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. ( 18185141 )
2008

Variations for Punctate Inner Choroidopathy

Expression for Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for Punctate Inner Choroidopathy

Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1 12.09 IL10 TNF
2
Show member pathways
12 IL10 TNF
3
Show member pathways
11.86 IL10 TNF
4 11.82 IL10 TNF
5 11.77 IL10 TNF
6
Show member pathways
11.76 IL10 TNF
7 11.6 IL10 TNF
8 11.58 IL10 TNF
9
Show member pathways
11.54 IL10 TNF
10 11.48 IL10 TNF
11 11.38 IL10 TNF
12 11.34 IL10 TNF
13 11.31 IL10 TNF
14 11.25 IL10 TNF
15 11.06 IL10 TNF
16 11.01 IL10 TNF
17
Show member pathways
10.86 IL10 TNF
18 10.81 IL10 TNF
19 10.7 IL10 TNF
20 10.5 IL10 TNF
21 10.1 IL10 TNF

GO Terms for Punctate Inner Choroidopathy

Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.54 IL10 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.52 IL10 TNF
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.51 IL10 TNF
4 response to organic substance GO:0010033 9.49 IL10 TNF
5 response to glucocorticoid GO:0051384 9.48 IL10 TNF
6 positive regulation of cytokine secretion GO:0050715 9.46 IL10 TNF
7 negative regulation of mitotic cell cycle GO:0045930 9.43 IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.4 IL10 TNF
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.37 IL10 TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.32 IL10 TNF
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 IL10 TNF
12 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
13 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
14 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 IL10 TNF

Sources for Punctate Inner Choroidopathy

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70 UMLS via Orphanet
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