PIC
MCID: PNC059
MIFTS: 33

Punctate Inner Choroidopathy (PIC) malady

Rare diseases category
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Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:42 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are Allograft rejection and B Cell Receptor Signaling Pathway. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

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Punctate Inner Choroidopathy, Aliases & Descriptions:

Name: Punctate Inner Choroidopathy 42 62
 
Pic 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Punctate Inner Choroidopathy

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Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Drug clinical trials:

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Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

32
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
2
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. (25370399)
2014
3
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. (25046400)
2014
4
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
5
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
6
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
7
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
8
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
9
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
10
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
11
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
12
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
13
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
14
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
15
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. (25389949)
2012
16
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
17
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
18
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
19
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
20
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
21
Punctate inner choroidopathy. (21056447)
2011
22
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
23
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
24
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
25
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
26
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. (21772986)
2011
27
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
28
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
29
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
30
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
31
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
32
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
33
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
34
Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. (17237756)
2008
35
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
36
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
37
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
38
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
39
Acute zonal occult outer retinopathy in the fellow eye 5 years after presentation of punctate inner choroidopathy. (16315044)
2006
40
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
41
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
42
Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. (16391624)
2005
43
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
44
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
45
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
46
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
47
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
48
Indocyanine green angiography in a case of punctate inner choroidopathy. (8664243)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Expression patterns in normal tissues for genes affiliated with Punctate Inner Choroidopathy

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Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
2
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.1TNF, IL10
39.1IL10, TNF
4
Show member pathways
9.1IL10, TNF
5
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1TNF, IL10
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
11
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL10, TNF
129.1IL10, TNF
139.1TNF, IL10
14
Show member pathways
9.1IL10, TNF
159.1IL10, TNF
169.1TNF, IL10
179.1TNF, IL10
189.1IL10, TNF
19
Show member pathways
IL27-mediated signaling events37
9.1IL10, TNF
209.1IL10, TNF

Compounds for genes affiliated with Punctate Inner Choroidopathy

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Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cdp571449.6IL10, TNF
2interferon gamma449.6IL10, TNF
3gabexate mesilate449.6TNF, IL10
4blys449.6TNF, IL10
5toxin-1449.6IL10, TNF
6ulinastatin449.6IL10, TNF
7mip 1alpha449.6TNF, IL10
8natalizumab44 1110.6IL10, TNF
95 aminosalicylic acid449.6TNF, IL10
10il-12449.6TNF, IL10
11adalimumab44 50 1111.6IL10, TNF
12indoleamine449.6IL10, TNF
13imiquimod44 61 28 1112.6TNF, IL10
14cyclosporine50 1110.5IL10, TNF
15polymyxin b449.5IL10, TNF
16groalpha449.5TNF, IL10
17okt3449.5TNF, IL10
18gm-csf44 2810.5IL10, TNF
19lipoteichoic acid449.5TNF, IL10
208-isoprostane449.5IL10, TNF
212,5-oligoadenylate449.5TNF, IL10
22polyinosinic-polycytidylic acid449.5TNF, IL10
23rolipram44 61 2811.5IL10, TNF
24etanercept44 50 1111.5IL10, TNF
25il 10449.5TNF, IL10
26mycophenolate mofetil44 50 1111.5TNF, IL10
27infliximab44 50 1111.5IL10, TNF
28tarc449.5IL10, TNF
29peptidoglycan44 2810.5TNF, IL10
30ivig449.5IL10, TNF
31ccl344 2810.5TNF, IL10
32pentoxifylline44 1110.5TNF, IL10
33neopterin449.5IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2449.4IL10, TNF
35rituximab44 50 1111.4TNF, IL10
36thalidomide44 50 61 1112.4IL10, TNF
37chloroquine44 2 50 28 1113.4IL10, TNF
38atorvastatin44 50 28 24 1113.4TNF, IL10
39prednisolone44 28 1111.4TNF, IL10
40hydrocortisone44 2 61 1112.4IL10, TNF
41tgf beta1449.4IL10, TNF
42simvastatin44 50 61 28 24 1114.3TNF, IL10
43endotoxin449.3IL10, TNF
44ionomycin449.3IL10, TNF
45prostacyclin449.2TNF, IL10
46tacrolimus44 50 1111.2IL10, TNF
47calcitriol44 61 24 1112.1IL10, TNF
48sb 20358044 6110.1IL10, TNF
49methotrexate50 44 1111.0TNF, IL10
50rantes448.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
5positive regulation of cytokine secretionGO:0507159.3IL10, TNF
6response to activityGO:0148239.2TNF, IL10
7response to glucocorticoidGO:0513849.2IL10, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
9positive regulation of transcription, DNA-templatedGO:0458939.1IL10, TNF
10response to drugGO:0424939.0TNF, IL10
11inflammatory responseGO:0069548.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet