MCID: PNC059
MIFTS: 31

Punctate Inner Choroidopathy malady

Category: Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

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Aliases & Descriptions for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 45 65
 
Pic 45

Classifications:



External Ids:

UMLS65 C0730321

Summaries for Punctate Inner Choroidopathy

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NIH Rare Diseases:45 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards based summary: Punctate Inner Choroidopathy, also known as pic, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include eye, liver and prostate.

Related Diseases for Punctate Inner Choroidopathy

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Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis10.9
2multifocal choroiditis10.6
3panuveitis10.5
4retinitis10.3
5acute zonal occult outer retinopathy10.3
6neuroretinitis10.1
7histoplasmosis10.1
8neuropathy10.1
9central serous chorioretinopathy10.1
10punctate palmoplantar keratoderma type 210.1IL10, TNF
11primary progressive freezing gait10.1IL10, TNF
12kearns-sayre syndrome10.1IL10, TNF
13multifocal lymphangioendotheliomatosis with thrombocytopenia10.1IL10, TNF
14alternating exotropia10.1IL10, TNF
15achalasia10.0IL10, TNF
16drug-induced mental disorder10.0IL10, TNF
17opisthorchiasis10.0IL10, TNF
18precursor b lymphoblastic lymphoma/leukemia10.0IL10, TNF
19hypercementosis10.0IL10, TNF
20prostate transitional cell carcinoma10.0IL10, TNF
21early-onset, autosomal dominant alzheimer disease10.0IL10, TNF
22moderately severe hemophilia a10.0IL10, TNF
23hydronephrosis10.0IL10, TNF
24streptococcal meningitis10.0IL10, TNF
25b cell deficiency10.0IL10, TNF
26cytoplasmic body myopathy10.0IL10, TNF
27hemorrhagic proctocolitis10.0IL10, TNF
28dancing eyes-dancing feet syndrome10.0IL10, TNF
29hemolytic anemia10.0IL10, TNF
30aniseikonia10.0IL10, TNF
31central nervous system melanocytic neoplasm10.0IL10, TNF
32goat milk allergy10.0IL10, TNF
33peripheral retinal degeneration10.0IL10, TNF
34idiopathic spinal cord herniation10.0IL10, TNF
35trench fever10.0IL10, TNF
36kernicterus due to isoimmunization10.0IL10, TNF
37placental abruption10.0IL10, TNF
38acute leukemia of ambiguous lineage10.0IL10, TNF
39meige syndrome10.0IL10, TNF
40vagus nerve neoplasm10.0IL10, TNF
41cholera10.0IL10, TNF
42tracheal stenosis10.0IL10, TNF
43constant exophthalmos10.0IL10, TNF
44tethered spinal cord syndrome10.0IL10, TNF
45blastomycosis10.0IL10, TNF
46lateral sclerosis10.0IL10, TNF
47progressive relapsing multiple sclerosis10.0IL10, TNF
48acute orbital inflammation10.0IL10, TNF
49postcholecystectomy syndrome10.0IL10, TNF
50trachoma10.0IL10, TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMDWithdrawnNCT01256580

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

33
Eye, Liver, Prostate, Lung, Heart, Spinal cord, Breast

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. (26965893)
2016
2
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. (26421890)
2015
3
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. (26955337)
2015
4
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. (25687028)
2015
5
The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy. (26266044)
2015
6
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. (25631844)
2015
7
Punctate inner choroidopathy in systemic lupus. (25648066)
2015
8
Punctate inner choroidopathy: a systematic review. (25741523)
2014
9
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. (24856311)
2014
10
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
11
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
12
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
13
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
14
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
15
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
16
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
17
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
18
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
19
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
20
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
21
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. (25389949)
2012
22
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. (25390960)
2012
23
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
24
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
25
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
26
Punctate inner choroidopathy. (21056447)
2011
27
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
28
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
29
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
30
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
31
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
32
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
33
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
34
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
35
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
36
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
37
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
38
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
39
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
40
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
41
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
42
Acute zonal occult outer retinopathy in the fellow eye 5 years after presentation of punctate inner choroidopathy. (16315044)
2006
43
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
44
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
45
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
46
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
47
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
48
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
29.1IL10, TNF
3
Show member pathways
9.1IL10, TNF
49.1IL10, TNF
59.1IL10, TNF
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
99.1IL10, TNF
109.1IL10, TNF
119.1IL10, TNF
12
Show member pathways
9.1IL10, TNF
139.1IL10, TNF
149.1IL10, TNF
159.1IL10, TNF
169.1IL10, TNF
179.1IL10, TNF
189.1IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:00328009.7IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
3negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
4negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
5response to glucocorticoidGO:00513849.5IL10, TNF
6positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL10, TNF
7inflammatory responseGO:00069549.2IL10, TNF
8immune responseGO:00069559.1IL10, TNF
9response to organic substanceGO:00100339.1IL10, TNF
10defense response to bacteriumGO:00427429.0IL10, TNF

Sources for Punctate Inner Choroidopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet