PIC
MCID: PNC059
MIFTS: 24

Punctate Inner Choroidopathy (PIC) malady

Summaries for Punctate Inner Choroidopathy

About this section
Sources:
42NIH Rare Diseases, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and panuveitis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are SIDS Susceptibility Pathways and Development PDGF signaling via STATs and NF-kB. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Aliases & Descriptions:

punctate inner choroidopathy 42 60
pic 42


Related Diseases for Punctate Inner Choroidopathy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis11.1
2panuveitis10.7
3histoplasmosis10.3
4neuropathy10.3
5retinitis10.3
6vesicoureteral reflux10.1
7blau syndrome10.0TNF
8aids dementia complex10.0TNF
9toxic shock syndrome10.0TNF
10chorioamnionitis10.0TNF
11arthropathy10.0TNF
12familial mediterranean fever10.0TNF
13respiratory failure10.0TNF
14interstitial lung disease10.0TNF
15psoriatic arthritis10.0TNF
16periodontal disease10.0TNF
17ankylosing spondylitis10.0TNF
18paracoccidioidomycosis10.0IL10
19cryoglobulinemia10.0
20acute pyelonephritis10.0
21meningitis10.0
22pyelonephritis10.0
23common variable immune deficiency10.0IL10
24vasculitis10.0TNF
25schistosomiasis10.0IL10
26tetanus10.0IL10
27myasthenia gravis10.0IL10
28lupus nephritis10.0IL10
29atopy10.0IL10
30leishmaniasis10.0IL10
31acute pancreatitis10.0IL10
32allergic rhinitis10.0IL10
33sarcoidosis10.0TNF
34alcoholic hepatitis10.0IL10, TNF
35acute graft versus host disease10.0TNF, IL10
36cerebral malaria10.0TNF, IL10
37periodontitis10.0IL10, TNF
38graft versus host disease10.0TNF, IL10
39septic shock10.0IL10, TNF
40hepatitis c10.0TNF, IL10
41congenital heart defect10.0TNF, IL10
42atopic dermatitis10.0IL10, TNF
43hypersensitivity reaction type ii disease10.0IL10, TNF
44cork-handlers' disease10.0TNF, IL10
45skin disease10.0TNF, IL10
46connective tissue disease10.0IL10, TNF
47uveitis10.0IL10, TNF
48ulcerative colitis10.0IL10, TNF
49sepsis10.0TNF, IL10
50inflammatory bowel disease10.0TNF, IL10

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Clinical Features for Punctate Inner Choroidopathy

About this section

Drugs & Therapeutics for Punctate Inner Choroidopathy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Punctate Inner Choroidopathy

Drug clinical trials:

Search ClinicalTrials for Punctate Inner Choroidopathy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Search CenterWatch for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

About this section

Anatomical Context for Punctate Inner Choroidopathy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Punctate Inner Choroidopathy:

32
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

About this section

Publications for Punctate Inner Choroidopathy

About this section

Genetic Variations for Punctate Inner Choroidopathy

About this section

Expression for genes affiliated with Punctate Inner Choroidopathy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

About this section
Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems
See all sources

Compounds for genes affiliated with Punctate Inner Choroidopathy

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
See all sources

Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1cdp571449.6IL10, TNF
2interferon gamma449.6IL10, TNF
3blys449.6TNF, IL10
4toxin-1449.6IL10, TNF
5mip 1alpha449.5IL10, TNF
6natalizumab44 1110.5TNF, IL10
7adalimumab44 49 1111.5IL10, TNF
8il-12449.5TNF, IL10
95 aminosalicylic acid449.5TNF, IL10
10indoleamine449.5IL10, TNF
11imiquimod44 28 59 1112.5TNF, IL10
12polymyxin b449.5IL10, TNF
13groalpha449.5TNF, IL10
14okt3449.5TNF, IL10
15gm-csf44 2810.5IL10, TNF
16lipoteichoic acid449.5TNF, IL10
178-isoprostane449.5IL10, TNF
18polyinosinic-polycytidylic acid449.5TNF, IL10
192,5-oligoadenylate449.5TNF, IL10
20etanercept44 49 1111.5IL10, TNF
21il 10449.5TNF, IL10
22infliximab44 49 1111.5IL10, TNF
23tarc449.5IL10, TNF
24peptidoglycan44 2810.5TNF, IL10
25ivig449.4IL10, TNF
26ccl344 2810.4TNF, IL10
27neopterin449.4IL10, TNF
28rituximab44 49 1111.4IL10, TNF
2915-deoxy-delta-12,14-prostaglandin j2449.4TNF, IL10
30thalidomide44 49 59 1112.4IL10, TNF
31chloroquine44 2 49 28 1113.4TNF, IL10
32atorvastatin44 49 28 11 2413.4IL10, TNF
33tgf beta1449.3IL10, TNF
34simvastatin44 49 59 28 11 2414.3TNF, IL10
35ionomycin449.3IL10, TNF
36prostacyclin449.2TNF, IL10
37tacrolimus44 49 1111.2IL10, TNF
38calcitriol44 59 11 2412.1IL10, TNF
39sb 20358044 5910.1IL10, TNF
40methotrexate44 49 1111.0TNF, IL10
41rantes448.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.3IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
5response to activityGO:0148239.2IL10, TNF
6positive regulation of cytokine secretionGO:0507159.2TNF, IL10
7response to glucocorticoid stimulusGO:0513849.1IL10, TNF
8inflammatory responseGO:0069549.1IL10, TNF
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL10, TNF
10response to drugGO:0424938.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Punctate Inner Choroidopathy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet