PIC
MCID: PNC059
MIFTS: 32

Punctate Inner Choroidopathy (PIC) malady

Rare diseases category
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Summaries for Punctate Inner Choroidopathy

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are Allograft rejection and B Cell Receptor Signaling Pathway. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

punctate inner choroidopathy 43 62
pic 43


Related Diseases for Punctate Inner Choroidopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Punctate Inner Choroidopathy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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33MalaCards
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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

33
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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52PubMed
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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
2
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
3
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
4
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
5
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
6
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
7
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
8
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
9
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
10
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
11
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
12
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
13
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
14
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
15
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
16
Punctate inner choroidopathy. (21056447)
2011
17
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
18
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
19
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
20
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
21
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. (21772986)
2011
22
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
23
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
24
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
25
Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. (20379284)
2010
26
Punctate inner choroidopathy: clinical features and outcomes. (20696997)
2010
27
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
28
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
29
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
30
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
31
Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. (17237756)
2008
32
Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. (18773266)
2008
33
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
34
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
35
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
36
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
37
Photodynamic therapy for subfoveal and juxtafoveal choroidal neovascularization associated with punctate inner choroidopathy. (17365803)
2007
38
Acute zonal occult outer retinopathy in the fellow eye 5 years after presentation of punctate inner choroidopathy. (16315044)
2006
39
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
40
Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. (16391624)
2005
41
Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. (12812908)
2003
42
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
43
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
44
Indocyanine green angiographic findings in a case of punctate inner choroidopathy. (9793776)
1998
45
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
46
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
47
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
48
Indocyanine green angiography in a case of punctate inner choroidopathy. (8664243)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 60Thomson Reuters, 54R&D Systems
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Pathways related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
2
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1TNF, IL10
39.1IL10, TNF
4
Show member pathways
9.1IL10, TNF
5
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1TNF, IL10
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
11
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL10, TNF
129.1IL10, TNF
139.1TNF, IL10
14
Show member pathways
9.1IL10, TNF
159.1IL10, TNF
169.1TNF, IL10
179.1TNF, IL10
189.1IL10, TNF
19
Show member pathways
IL27-mediated signaling events38
9.1IL10, TNF
209.1IL10, TNF

Compounds for genes affiliated with Punctate Inner Choroidopathy

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cdp571459.6IL10, TNF
2interferon gamma459.6IL10, TNF
3gabexate mesilate459.6TNF, IL10
4blys459.6TNF, IL10
5toxin-1459.6IL10, TNF
6ulinastatin459.6IL10, TNF
7mip 1alpha459.6TNF, IL10
8natalizumab45 1110.6IL10, TNF
95 aminosalicylic acid459.6TNF, IL10
10il-12459.6TNF, IL10
11adalimumab45 51 1111.6IL10, TNF
12indoleamine459.6IL10, TNF
13imiquimod45 61 29 1112.6TNF, IL10
14cyclosporine51 1110.5IL10, TNF
15polymyxin b459.5IL10, TNF
16groalpha459.5TNF, IL10
17okt3459.5TNF, IL10
18gm-csf45 2910.5IL10, TNF
19lipoteichoic acid459.5TNF, IL10
208-isoprostane459.5IL10, TNF
212,5-oligoadenylate459.5TNF, IL10
22polyinosinic-polycytidylic acid459.5TNF, IL10
23rolipram45 61 2911.5IL10, TNF
24etanercept45 51 1111.5IL10, TNF
25il 10459.5TNF, IL10
26mycophenolate mofetil45 51 1111.5TNF, IL10
27infliximab45 51 1111.5IL10, TNF
28tarc459.5IL10, TNF
29peptidoglycan45 2910.5TNF, IL10
30ivig459.5IL10, TNF
31ccl345 2910.5TNF, IL10
32pentoxifylline45 1110.5TNF, IL10
33neopterin459.5IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2459.4IL10, TNF
35rituximab45 51 1111.4TNF, IL10
36thalidomide45 51 61 1112.4IL10, TNF
37chloroquine45 3 51 29 1113.4IL10, TNF
38atorvastatin45 51 29 24 1113.4TNF, IL10
39prednisolone45 29 1111.4TNF, IL10
40hydrocortisone45 3 61 1112.4IL10, TNF
41tgf beta1459.4IL10, TNF
42simvastatin45 51 61 29 24 1114.3TNF, IL10
43endotoxin459.3IL10, TNF
44ionomycin459.3IL10, TNF
45prostacyclin459.2TNF, IL10
46tacrolimus45 51 1111.2IL10, TNF
47calcitriol45 61 24 1112.1IL10, TNF
48sb 20358045 6110.1IL10, TNF
49methotrexate51 45 1111.0TNF, IL10
50rantes458.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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16Gene Ontology
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Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
5positive regulation of cytokine secretionGO:0507159.3IL10, TNF
6response to activityGO:0148239.2TNF, IL10
7response to glucocorticoidGO:0513849.2IL10, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
9positive regulation of transcription, DNA-templatedGO:0458939.1IL10, TNF
10response to drugGO:0424939.0TNF, IL10
11inflammatory responseGO:0069548.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet