PIC
MCID: PNC059
MIFTS: 32

Punctate Inner Choroidopathy (PIC) malady

Rare diseases category

Summaries for Punctate Inner Choroidopathy

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Punctate inner choroidopathy (pic) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. the majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (cnv). the cause of pic is not known, but it is thought to involve both genetic predisposition and environmental factors. the majority of affected individuals who do not have cnv do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery. last updated: 1/4/2012

MalaCards: Punctate Inner Choroidopathy, also known as PIC, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (interleukin 10), and among its related pathways are Allograft rejection and B Cell Receptor Signaling Pathway. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Punctate Inner Choroidopathy

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

punctate inner choroidopathy 44 63
pic 44


Related Diseases for Punctate Inner Choroidopathy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to punctate inner choroidopathy

Symptoms for Punctate Inner Choroidopathy

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Drugs & Therapeutics for Punctate Inner Choroidopathy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Punctate Inner Choroidopathy

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Anatomical Context for Punctate Inner Choroidopathy

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Sources:
34MalaCards
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MalaCards organs/tissues related to Punctate Inner Choroidopathy:

34
Eye

Animal Models for Punctate Inner Choroidopathy or affiliated genes

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Publications for Punctate Inner Choroidopathy

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Sources:
53PubMed
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Articles related to Punctate Inner Choroidopathy:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. (23584703)
2013
2
Punctate inner choroidopathy: a clinical case report. (24163685)
2013
3
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. (23769333)
2013
4
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. (23805787)
2013
5
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. (22954947)
2012
6
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. (22210152)
2012
7
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. (22481479)
2012
8
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. (23163572)
2012
9
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. (22352824)
2012
10
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. (24269388)
2012
11
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (22824619)
2012
12
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. (22120962)
2012
13
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. (21357402)
2011
14
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. (21478811)
2011
15
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. (21275596)
2011
16
Punctate inner choroidopathy. (21056447)
2011
17
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. (21770809)
2011
18
Clinical features of punctate inner choroidopathy in Chinese patients. (21499193)
2011
19
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. (21350285)
2011
20
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. (21188681)
2011
21
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. (21772986)
2011
22
Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. (20224465)
2010
23
Punctate inner choroidopathy in mother and daughter. (21052920)
2010
24
Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. (20714365)
2010
25
Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. (20379284)
2010
26
Punctate inner choroidopathy: clinical features and outcomes. (20696997)
2010
27
Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy. (18617903)
2009
28
Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. (18369374)
2008
29
Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. (18412603)
2008
30
Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. (18185141)
2008
31
Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. (17237756)
2008
32
Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. (18773266)
2008
33
Punctate inner choroidopathy: a survey analysis of 77 persons. (17434588)
2007
34
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. (18046221)
2007
35
Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. (17660991)
2007
36
Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. (17459318)
2007
37
Photodynamic therapy for subfoveal and juxtafoveal choroidal neovascularization associated with punctate inner choroidopathy. (17365803)
2007
38
Acute zonal occult outer retinopathy in the fellow eye 5 years after presentation of punctate inner choroidopathy. (16315044)
2006
39
Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. (17151504)
2006
40
Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. (16391624)
2005
41
Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. (12812908)
2003
42
Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. (12096982)
2002
43
Multifocal choroiditis with panuveitis and punctate inner choroidopathy: a mini review. (10546386)
1999
44
Indocyanine green angiographic findings in a case of punctate inner choroidopathy. (9793776)
1998
45
Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. (9003340)
1996
46
Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. (8684800)
1996
47
Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. (8862067)
1996
48
Indocyanine green angiography in a case of punctate inner choroidopathy. (8664243)
1996
49
Punctate inner choroidopathy and its differential diagnosis. (2064259)
1991
50
Punctate inner choroidopathy. (6208783)
1984

Variations for Punctate Inner Choroidopathy

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Expression for genes affiliated with Punctate Inner Choroidopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for genes affiliated with Punctate Inner Choroidopathy

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters, 55R&D Systems
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Pathways related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL10, TNF
2
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1TNF, IL10
39.1IL10, TNF
4
Show member pathways
9.1IL10, TNF
5
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1TNF, IL10
6
Show member pathways
9.1IL10, TNF
7
Show member pathways
9.1IL10, TNF
8
Show member pathways
9.1IL10, TNF
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
11
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1IL10, TNF
129.1IL10, TNF
139.1TNF, IL10
14
Show member pathways
9.1IL10, TNF
159.1IL10, TNF
169.1TNF, IL10
179.1TNF, IL10
189.1IL10, TNF
19
Show member pathways
IL27-mediated signaling events39
9.1IL10, TNF
209.1IL10, TNF

Compounds for genes affiliated with Punctate Inner Choroidopathy

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cdp571469.6IL10, TNF
2interferon gamma469.6IL10, TNF
3gabexate mesilate469.6TNF, IL10
4blys469.6TNF, IL10
5toxin-1469.6IL10, TNF
6ulinastatin469.6IL10, TNF
7mip 1alpha469.6TNF, IL10
8natalizumab46 1210.6IL10, TNF
95 aminosalicylic acid469.6TNF, IL10
10il-12469.6TNF, IL10
11adalimumab46 52 1211.6IL10, TNF
12indoleamine469.6IL10, TNF
13imiquimod46 62 30 1212.6TNF, IL10
14cyclosporine52 1210.5IL10, TNF
15polymyxin b469.5IL10, TNF
16groalpha469.5TNF, IL10
17okt3469.5TNF, IL10
18gm-csf46 3010.5IL10, TNF
19lipoteichoic acid469.5TNF, IL10
208-isoprostane469.5IL10, TNF
212,5-oligoadenylate469.5TNF, IL10
22polyinosinic-polycytidylic acid469.5TNF, IL10
23rolipram46 62 3011.5IL10, TNF
24etanercept46 52 1211.5IL10, TNF
25il 10469.5TNF, IL10
26mycophenolate mofetil46 52 1211.5TNF, IL10
27infliximab46 52 1211.5IL10, TNF
28tarc469.5IL10, TNF
29peptidoglycan46 3010.5TNF, IL10
30ivig469.5IL10, TNF
31ccl346 3010.5TNF, IL10
32pentoxifylline46 1210.5TNF, IL10
33neopterin469.5IL10, TNF
3415-deoxy-delta-12,14-prostaglandin j2469.4IL10, TNF
35rituximab46 52 1211.4TNF, IL10
36thalidomide46 52 62 1212.4IL10, TNF
37chloroquine46 3 52 30 1213.4IL10, TNF
38atorvastatin46 52 30 25 1213.4TNF, IL10
39prednisolone46 30 1211.4TNF, IL10
40hydrocortisone46 3 62 1212.4IL10, TNF
41tgf beta1469.4IL10, TNF
42simvastatin46 52 62 30 25 1214.3TNF, IL10
43endotoxin469.3IL10, TNF
44ionomycin469.3IL10, TNF
45prostacyclin469.2TNF, IL10
46tacrolimus46 52 1211.2IL10, TNF
47calcitriol46 62 25 1212.1IL10, TNF
48sb 20358046 6210.1IL10, TNF
49methotrexate52 46 1211.0TNF, IL10
50rantes468.8IL10, TNF

GO Terms for genes affiliated with Punctate Inner Choroidopathy

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17Gene Ontology
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Biological processes related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3TNF, IL10
4negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
5positive regulation of cytokine secretionGO:0507159.3IL10, TNF
6response to activityGO:0148239.2TNF, IL10
7response to glucocorticoidGO:0513849.2IL10, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
9positive regulation of transcription, DNA-templatedGO:0458939.1IL10, TNF
10response to drugGO:0424939.0TNF, IL10
11inflammatory responseGO:0069548.8IL10, TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Punctate Inner Choroidopathy

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Sources for Punctate Inner Choroidopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet