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MCID: PRT058
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Pure Autonomic Failure malady |
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Sources: 30NIH Rare Diseases, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NINDS: Orthostatic hypotension is a sudden fall in blood pressure that occurs when a person assumes a standing position. It is due
to a lesion of the baroreflex loop, which senses a change in blood pressure and adjusts heart rate and activates sympathetic
nerve system fibers to cause the blood vessels to narrow and correct blood pressure. It may also be caused by hypovolemia
(a decreased amount of blood in the body), resulting from the excessive use of diuretics, vasodilators, or other types of
drugs, dehydration, or prolonged bed rest. The disorder may be associated with Addison's disease, diabetes, and certain neurological
disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly known as Shy-Drager syndrome), autonomic
system neuropathies, and other dysautonomias. Symptoms, which generally occur after sudden standing, include dizziness, lightheadedness,
blurred vision, and syncope (temporary loss of consciousness).31
MalaCards: Pure Autonomic Failure, also known as bradbury-eggleston syndrome, is related to dysautonomia and autonomic dysfunction. An important gene associated with Pure Autonomic Failure is DBH (dopamine beta-hydroxylase (dopamine beta-monooxygenase)), and among its related pathways are Tyrosine metabolism p.1 (dopamine) and Tyrosine metabolism p.1 (dopamine). The compounds choline and alpha-methyl-p-tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are nervous system and cardiovascular system. NIH Rare Diseases: Pure autonomic failure is characterized by generalized autonomic failure without involving the brain or spinal cord (central nervous system). The autonomic nervous system is the part of our bodies that controls involuntary actions, such as the widening or narrowing of our blood vessels. Failure of this system can cause a variety of symptoms. The most common symptom of pure autonomic failure is orthostatic hypotension. Other symptoms may include decreased sweating, heat intolerance, in ability to empty the bladder, erectile dysfunction, incontinence or constipation, and pupil changes. The cause of this condition is unknown.30 Wikipedia: Pure autonomic failure, also known as Bradbury-Eggleston syndrome or idiopathic orthostatic hypotension,...44 more... |
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Sources: 30NIH Rare Diseases, 31NINDS, 32Novoseek , 43UMLS See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for pure autonomic failure Drug clinical trials:Search ClinicalTrials for pure autonomic failure Search NIH Clinical Center for pure autonomic failure Search CenterWatch for pure autonomic failure |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to pure autonomic failure:22Brain, Spinal cord, Heart, Skin
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to pure autonomic failure:25
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Sources: 35PubMed See all sources |
Articles related to pure autonomic failure:
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Sources: 1BioGPS See all sources |
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Sources: 41Thomson Reuters, 10EMD Millipore, 34PharmGKB, 20KEGG, 38Reactome, 3Cell Signaling Technology See all sources |
Pathways related to pure autonomic failure according to GeneDecks:
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Sources: 32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience See all sources |
Compounds related to pure autonomic failure according to GeneDecks:(show top 50) (show all 54)
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Sources: 12Gene Ontology See all sources |
Biological processes related to pure autonomic failure according to GeneDecks:
Molecular functions related to pure autonomic failure according to GeneDecks:
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