MCID: PRT058
MIFTS: 50

Pure Autonomic Failure

Categories: Rare diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Pure Autonomic Failure

MalaCards integrated aliases for Pure Autonomic Failure:

Name: Pure Autonomic Failure 50 56 52 69
Idiopathic Orthostatic Hypotension 50 56 69
Bradbury-Eggleston Syndrome 50 51 56
Orthostatic Hypotension 50 51 29
Bradbury Eggleston Syndrome 50
Pure Idiopatic Dysautonomia 56
Hypotension Orthostatic 52
Pure Dysautonomia 56
Paf 56

Characteristics:

Orphanet epidemiological data:

56
pure autonomic failure
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA441
MESH via Orphanet 43 C544351 D054970
UMLS via Orphanet 70 C0393911 C2931939
ICD10 via Orphanet 34 G90.3
ICD10 33 I95.1

Summaries for Pure Autonomic Failure

NINDS : 51 Orthostatic hypotension is a sudden fall in blood pressure that occurs when a person assumes a standing position. It is due to a lesion of the baroreflex loop, which senses a change in blood pressure and adjusts heart rate and activates sympathetic nerve system fibers to cause the blood vessels to narrow and correct blood pressure. It may also be caused by hypovolemia (a decreased amount of blood in the body), resulting from the excessive use of diuretics, vasodilators, or other types of drugs, dehydration, or prolonged bed rest. The disorder may be associated with Addison's disease, diabetes, and certain neurological disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly known as Shy-Drager syndrome), autonomic system neuropathies, and other dysautonomias. Symptoms, which generally occur after sudden standing, include dizziness, lightheadedness, blurred vision, and syncope (temporary loss of consciousness).

MalaCards based summary : Pure Autonomic Failure, also known as idiopathic orthostatic hypotension, is related to adenocarcinoma and pleurisy. An important gene associated with Pure Autonomic Failure is DBH (Dopamine Beta-Hydroxylase), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Circadian entrainment. The drugs Midodrine and Droxidopa have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

NIH Rare Diseases : 50 pure autonomic failure is characterized by generalized autonomic failure without central nervous system (brain or spinal cord) involvement. the autonomic nervous system is the part of our bodies that controls involuntary actions, such as the widening or narrowing of our blood vessels. failure of this system can cause a variety of symptoms. the most common symptom of pure autonomic failure is orthostatic hypotension. other symptoms may include decreased sweating, heat intolerance, inability to empty the bladder, erectile dysfunction, incontinence or constipation, and pupil changes. the cause of this condition is usually unknown. last updated: 4/9/2015

Wikipedia : 72 Pure autonomic failure (PAF), also known as Bradbury-Eggleston syndrome or idiopathic orthostatic... more...

Related Diseases for Pure Autonomic Failure

Diseases related to Pure Autonomic Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.9 ACE REN
2 pleurisy 29.7 MAOA MAOB
3 multiple system atrophy 11.5
4 autonomic dysfunction 11.3
5 dysautonomia 11.3
6 primary orthostatic hypotension 11.1
7 platelet-activating factor acetylhydrolase deficiency 11.0
8 dysautonomia, familial 10.9
9 hereditary paraganglioma-pheochromocytoma syndromes 10.7 DBH TH
10 hypothyroidism due to iodide transport defect 10.7 ACE REN
11 epileptic encephalopathy, early infantile, 31 10.7 DBH DDC
12 primary hyperoxaluria 10.7 ACE REN
13 mody, type ii 10.7 ACE REN
14 listeriosis 10.7 ACE REN
15 sm-ahnmd 10.6 DDC TH
16 non-congenital cyst of kidney 10.6 ACE REN
17 central cervical cord syndrome 10.6 DBH SNCA
18 orthostatic intolerance 10.6
19 cervical mullerian papilloma 10.6 ACE EPO
20 ganglioneuroma 10.5 DDC SNCA TH
21 carpal tunnel syndrome, familial 10.5 DBH TTR
22 rumination disorder 10.5 DBH EPO
23 hypogonadotropic hypogonadism without anosmia, x-linked 10.4 ACHE TH
24 atrial septal defect 7, with or without av conduction defects 10.4 ACE NPPA REN
25 hypodontia of incisors and premolars 10.4 ACE NPPA REN
26 chylocele of tunica vaginalis 10.4 ACE NPPA REN
27 myopia 10.4 ACE NPPA REN
28 lymphadenitis 10.4 ACE NPPA REN
29 renal clear cell carcinoma 10.4 ACE NPPA REN
30 calcinosis 10.4 ACE EPO REN
31 voyeurism 10.4 ACE REN
32 craniosynostosis 7 10.4 ACE NPPA REN
33 sebaceous gland disease 10.4 ACHE SNCA
34 hypopigmentation of eyelid 10.3 PDE5A SNCA
35 synovial chondromatosis 10.3 ACE NPPA
36 survival motor neuron spinal muscular atrophy 10.3 ACE REN TTR
37 pauci-immune glomerulonephritis with anca 10.3 DBH MAOA TH
38 supranuclear palsy, progressive atypical 10.3 ACHE SNCA TH
39 riedel's fibrosing thyroiditis 10.3 MAOB SNCA
40 spasmodic dystonia 10.2 DDC MAOB
41 epithelial predominant pulmonary blastoma 10.2 ACE NPPA PDE5A
42 broad ligament malignant neoplasm 10.2 ACE DBH EPO REN
43 repetitive stress injuries 10.2 DBH DDC NPPA REN
44 pheochromocytoma 10.2 DBH DDC NPPA TH
45 gastroesophageal reflux 10.2
46 endotheliitis 10.1
47 clitoris cancer 10.1 ACE EPO NPPA REN
48 malignant type ab thymoma 10.1 ACE ACHE REN
49 craniosynostosis 10.1 ACE EPO NPPA REN
50 conjunctival pigmentation 10.1 MAOA MAOB

Graphical network of the top 20 diseases related to Pure Autonomic Failure:



Diseases related to Pure Autonomic Failure

Symptoms & Phenotypes for Pure Autonomic Failure

MGI Mouse Phenotypes related to Pure Autonomic Failure:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 SNCA TH MAOA MAOB ACE NEDD4L
2 homeostasis/metabolism MP:0005376 10.07 EPO TH MAOA TTR MAOB ACE
3 cardiovascular system MP:0005385 10.02 EPO TH MAOA ACE NEDD4L DBH
4 nervous system MP:0003631 9.85 SNCA GNB3 TH MAOA MAOB NEDD4L
5 renal/urinary system MP:0005367 9.5 SNCA MAOB ACE NEDD4L NPPA REN
6 vision/eye MP:0005391 9.17 GNB3 TH ACHE NEDD4L DBH DDC

Drugs & Therapeutics for Pure Autonomic Failure

Drugs for Pure Autonomic Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midodrine Approved Phase 4,Phase 1 133163-28-7, 42794-76-3 4195
2
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23651-95-8 443940
3 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
4 Adrenergic Agents Phase 4,Phase 1,Phase 2,Early Phase 1
5 Adrenergic Agonists Phase 4,Phase 1,Phase 2
6 Adrenergic alpha-Agonists Phase 4,Phase 1,Phase 2
7 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
9 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2,Early Phase 1
10 Antiparkinson Agents Phase 4,Phase 3,Phase 2,Phase 1
11
Dopamine Approved Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
12
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
13 Dopamine Agents Phase 3,Phase 2,Phase 1
14 Protective Agents Phase 3,Phase 1
15 Antibodies Phase 2, Phase 3
16 gamma-Globulins Phase 2, Phase 3
17 Immunoglobulins Phase 2, Phase 3
18 Immunoglobulins, Intravenous Phase 2, Phase 3
19 Rho(D) Immune Globulin Phase 2, Phase 3
20
Fludrocortisone Approved Phase 2 127-31-1 31378
21
Norepinephrine Approved Phase 1, Phase 2 51-41-2 439260
22
Carbidopa Approved Phase 2,Phase 1 28860-95-9 34359 38101
23
Naloxone Approved, Vet_approved Phase 2 465-65-6 5284596
24 Anticonvulsants Phase 2,Phase 1
25 Anti-Inflammatory Agents Phase 2,Phase 1
26 Bromides Phase 2,Phase 1
27 Cholinergic Agents Phase 2,Phase 1
28 Cholinesterase Inhibitors Phase 2,Phase 1
29 Pyridostigmine Bromide Phase 2,Phase 1 101-26-8
30 Aromatic Amino Acid Decarboxylase Inhibitors Phase 2,Phase 1
31 Atomoxetine Hydrochloride Phase 2,Phase 1
32 Neurotransmitter Uptake Inhibitors Phase 2,Phase 1,Early Phase 1
33 Narcotic Antagonists Phase 2
34 Narcotics Phase 2
35
Captopril Approved Phase 1 62571-86-2 44093
36
Losartan Approved Phase 1 114798-26-4 3961
37
Acarbose Approved, Investigational Phase 1 56180-94-0 441184
38
Acetazolamide Approved, Vet_approved Phase 1 59-66-5 1986
39
Armodafinil Approved, Investigational Phase 1 112111-43-0
40
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
41
Diphenhydramine Approved Phase 1 58-73-1, 147-24-0 3100
42
Ephedrine Approved Phase 1,Early Phase 1 299-42-3 9294
43
Ergotamine Approved Phase 1 113-15-5 8223
44
Histamine Approved, Investigational Phase 1 75614-87-8, 51-45-6 774
45
Ibuprofen Approved Phase 1 15687-27-1 3672
46
Indomethacin Approved, Investigational Phase 1 53-86-1 3715
47
Levodopa Approved Phase 1 59-92-7 6047
48
Methylphenidate Approved, Investigational Phase 1 113-45-1 4158
49
Modafinil Approved, Investigational Phase 1 68693-11-8 4236
50
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441

Interventional clinical trials:

(show top 50) (show all 68)

id Name Status NCT ID Phase Drugs
1 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
2 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
3 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
4 A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Completed NCT00782340 Phase 3 Placebo;Droxidopa
5 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
6 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Completed NCT01132326 Phase 3 Droxidopa
7 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
8 Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Completed NCT01522235 Phase 2, Phase 3 Double blinded IVIg
9 A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy Terminated NCT01927055 Phase 3 Droxidopa;Placebo
10 Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment Unknown status NCT01993680 Phase 2 Pyridostigmine bromide;fludrocortisone
11 Fipamezole in Neurogenic Orthostatic Hypotension Unknown status NCT00758849 Phase 2 Placebo;Fipamezole
12 Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI Completed NCT02307526 Phase 2 Pyridostigmine Bromide
13 Intravenous Norepinephrine for Orthostatic Hypotension Completed NCT01285908 Phase 1, Phase 2 Intravenous Norepinephrine Infusion
14 Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa Completed NCT00983814 Phase 2 Droxidopa+Carbidopa;Placebo
15 Norepinephrine Transporter Blockade, Autonomic Failure Recruiting NCT02796209 Phase 2 Atomexetine;Placebo
16 Norepinephrine Transporter Blockade, Autonomic Failure (NETAF) Recruiting NCT02784535 Phase 2 Atomoxetine;Placebo
17 TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Recruiting NCT02705755 Phase 2 TD-9855;Placebo
18 Naloxone, Hypoglycemia and Exercise Recruiting NCT03149770 Phase 2 Naloxone;Placebo
19 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
20 Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension Unknown status NCT01521221 Phase 1
21 Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Completed NCT01292694 Phase 1 Losartan;Captopril;Placebo
22 Treatment of Orthostatic Hypotension in Autonomic Failure Completed NCT00223691 Phase 1 Atomoxetine;Acarbose;Pyridostigmine Bromide;Yohimbine;Midodrine HCl;placebo;Modafinil;Octreotide;Diphenhydramine Hydrochloride;Ranitidine HCL;Tranylcypromine;Ergotamine/ Caffeine;Celecoxib;Pseudoephedrine;Methylphenidate;Indomethacin;Ibuprofen;Oxymetazoline 0.05% nasal solution;Acetazolamide;Rivastigmine tartrate;Carbidopa/levodopa
23 Treatment of Supine Hypertension in Autonomic Failure Completed NCT00223717 Phase 1 Clonidine;Nitroglycerin transdermal;Dipyridamole/ Aspirin (Aggrenox);Desmopressin (DDAVP);Sildenafil;Nifedipine;Hydralazine;Hydrochlorothiazide;Placebo;Bosentan;Diltiazem;Eplerenone;guanfacine;captopril;carbidopa;losartan;metoprolol tartrate;nebivolol hydrochloride;prazosin hydrochloride;tamsulosin hydrochloride;aliskiren
24 The Autonomic Nervous System and Obesity Completed NCT00179023 Phase 1 Trimethaphan;Trimethaphan;Pseudoephedrine
25 The Role of Endothelin in the Supine Hypertension of Autonomic Failure Recruiting NCT01119417 Phase 1 BQ123;BQ123;Bq123;BQ123;Saline
26 Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure Recruiting NCT02429557 Phase 1 Placebo pill;midodrine
27 Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Recruiting NCT02897063 Phase 1 Droxidopa;Midodrine;Placebo
28 Liver Glycogen and Hypoglycemia in Humans Not yet recruiting NCT03241706 Phase 1 Fructose;Saline;Somatostatin;Insulin;Glucagon;Dextrose solution
29 Risk Prediction in Type II Diabetics With Ischemic Heart Disease Unknown status NCT01422057
30 Physiopathological Study of Autonomic Failure in Parkinson's Disease Completed NCT01748409
31 Autonomic Failure Patients for RNA Blood Sampling Completed NCT00742586
32 Plasma Exchange for Autoimmune Autonomic Failure Completed NCT00359346
33 Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension Completed NCT01316666
34 Nebivolol in the Supine Hypertension of Autonomic Failure Completed NCT01044693 Placebo;Nebivolol 5 mg;metoprolol tartrate 50 mg;Sildenafil25 mg
35 Mechanisms Responsible for Hypoglycemia Associated Autonomic Failure Completed NCT00678145 naloxone
36 Nitric Oxide and the Autonomic Nervous System Completed NCT00178919 L-NMMA;Trimethaphan
37 Hypoglycemia Associated Autonomic Failure in Type 1 DM Completed NCT00592670 Fluoxetine;Placebo
38 Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q2 Completed NCT00592332 Alprazolam
39 Abdominal Compression in Orthostatic Hypotension Completed NCT01223391
40 Study of Idiopathic Edema Completed NCT01681927
41 Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy Completed NCT02690168
42 Posture Detection for Automated Abdominal Binder Completed NCT02280369
43 UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation Completed NCT02178787
44 Importance of Liver Innervation for the Osmopressor Response in Humans Completed NCT01237431
45 Study of Norepinephrine Levels and Sympathetic Nervous System Activity Completed NCT00001329
46 Recurrent Hypoglycaemia in Type 1 Diabetes Completed NCT01337362
47 Treatment of Supine Hypertension in Autonomic Failure (CPAP) Recruiting NCT03312556 Placebo
48 Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension Recruiting NCT03042988
49 Local Heat Stress in Autonomic Failure Patients With Supine Hypertension Recruiting NCT02417415
50 Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure Recruiting NCT02591173 Early Phase 1 Angiotensin-(1-7);Saline

Search NIH Clinical Center for Pure Autonomic Failure

Genetic Tests for Pure Autonomic Failure

Genetic tests related to Pure Autonomic Failure:

id Genetic test Affiliating Genes
1 Orthostatic Hypotension 29

Anatomical Context for Pure Autonomic Failure

MalaCards organs/tissues related to Pure Autonomic Failure:

39
Heart, Brain, Spinal Cord, Liver, Skin, Testes, Cingulate Cortex

Publications for Pure Autonomic Failure

Articles related to Pure Autonomic Failure:

(show top 50) (show all 91)
id Title Authors Year
1
Letter on "Natural history of pure autonomic failure: A United States prospective cohort". ( 28472851 )
2017
2
Pure autonomic failure without alpha-synuclein pathology: an evolving understanding of a heterogeneous disease. ( 28236005 )
2017
3
Natural history of pure autonomic failure: A United States prospective cohort. ( 28093795 )
2017
4
Pure autonomic failure: Predictors of conversion to clinical CNS involvement. ( 28202694 )
2017
5
Pure autonomic failure. ( 28717053 )
2017
6
Reply to "Pure autonomic failure vs. Manifest CNS synucleinopathy: Relevance of stridor and autonomic biomarkers". ( 28472861 )
2017
7
Is pure autonomic failure a distinct nosologic entity? ( 28303413 )
2017
8
Pure autonomic failure versus prodromal dysautonomia in Parkinsona89s disease: Insights from the bedside. ( 28164144 )
2017
9
Very late-onset pure autonomic failure. ( 28436596 )
2017
10
Is pure autonomic failure an early marker for Parkinson disease, dementia with Lewy bodies, and multiple system atrophy? And other updates on recent autonomic research. ( 28255741 )
2017
11
Pure autonomic failure without synucleinopathy. ( 28188385 )
2017
12
Managing neurogenic orthostatic hypotension in a patient presenting with pure autonomic failure who later developed Parkinson disease. ( 28699048 )
2017
13
A case series of REM sleep behavior disorder in pure autonomic failure. ( 27757562 )
2016
14
Skin nerve misfolded I+-synuclein in pure autonomic failure and Parkinson disease. ( 26606657 )
2016
15
Pure Autonomic Failure. ( 27338613 )
2016
16
Successful long-term ambulatory norepinephrine infusions in a patient with pure autonomic failure. ( 26138858 )
2015
17
Antemortem detection of colonic I+-synuclein pathology in a patient with pure autonomic failure. ( 25319021 )
2014
18
Skin sympathetic fiber I+-synuclein deposits: A potential biomarker for pure autonomic failure. ( 24379100 )
2014
19
Alpha-synuclein accumulation in a patient with Auerbach's plexus of pure autonomic failure. ( 25274243 )
2014
20
Skin sympathetic fiber I+-synuclein deposits: a potential biomarker for pure autonomic failure. ( 23390175 )
2013
21
Pure autonomic failure. ( 24095130 )
2013
22
Pure autonomic failure with cold induced sweating. ( 23511064 )
2013
23
Incidence of cerebrovascular lesions in pure autonomic failure. ( 23706609 )
2013
24
I+-Synuclein in the skin nerve of pure autonomic failure. ( 22186004 )
2011
25
alpha-synuclein accumulation in skin nerve fibers revealed by skin biopsy in pure autonomic failure. ( 20157164 )
2010
26
Autonomic innervation in multiple system atrophy and pure autonomic failure. ( 20660924 )
2010
27
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease? ( 20157156 )
2010
28
Renal impairment of pure autonomic failure. ( 19738158 )
2009
29
Exercise-induced hypertension in pure autonomic failure. ( 19538201 )
2009
30
Reduced perfusion in the anterior cingulate cortex of patients with pure autonomic failure: an 123I-IMP SPECT study. ( 19684240 )
2009
31
Hyposmia in pure autonomic failure. ( 19433741 )
2009
32
Differences in skin sympathetic involvements between two chronic autonomic disorders: multiple system atrophy and pure autonomic failure. ( 18805037 )
2009
33
Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases. ( 19201246 )
2009
34
Frequent nocturnal vocalization in pure autonomic failure. ( 18534130 )
2008
35
Effects of water drinking on cardiovascular responses to supine exercise and on orthostatic hypotension after exercise in pure autonomic failure. ( 18469030 )
2008
36
Central dopamine deficiency in pure autonomic failure. ( 18363034 )
2008
37
Pure autonomic failure followed by amyotrophy. ( 17339594 )
2007
38
Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies. ( 16818943 )
2006
39
Cerebral vasomotor reactivity in Parkinson's disease, multiple system atrophy and pure autonomic failure. ( 16438986 )
2006
40
Chronic intestinal pseudo-obstruction as the initial feature of pure autonomic failure. ( 16705209 )
2006
41
Skin vasomotor reflex responses in two contrasting groups of autonomic failure: multiple system atrophy and pure autonomic failure. ( 16845569 )
2006
42
Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure. ( 16404729 )
2006
43
Pure autonomic failure with altered dopamine transporter imaging. ( 16606777 )
2006
44
Stress induced hypotension in pure autonomic failure. ( 16354738 )
2006
45
Cognitive functioning in orthostatic hypotension due to pure autonomic failure. ( 16683070 )
2006
46
Cevimeline hydrochloride improved cholinergic dysfunction in a patient with pure autonomic failure. ( 15995794 )
2006
47
REM sleep behavioral disorder in pure autonomic failure (PAF). ( 16505328 )
2006
48
Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. ( 16269589 )
2005
49
Rate of change in cerebral oxygenation and blood pressure in response to passive changes in posture: a comparison between pure autonomic failure patients and controls. ( 16594152 )
2005
50
Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy. ( 15654557 )
2005

Variations for Pure Autonomic Failure

Expression for Pure Autonomic Failure

Search GEO for disease gene expression data for Pure Autonomic Failure.

Pathways for Pure Autonomic Failure

Pathways related to Pure Autonomic Failure according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 DDC GNB3 MAOA MAOB NPPA SNCA
2
Show member pathways
12.51 ACHE DDC GNB3 MAOA MAOB TH
3 12.4 DBH DDC GNB3 SNCA TH
4
Show member pathways
12.11 ACE ACHE GNB3 REN
5 12.05 DDC GNB3 MAOA TH
6
Show member pathways
11.83 DDC MAOA MAOB TH
7 11.79 DDC GNB3 MAOA MAOB
8 11.66 DDC SNCA TH
9 11.66 DBH DDC MAOA TH
10
Show member pathways
11.43 DBH DDC MAOA MAOB TH
11
Show member pathways
11.3 DBH DDC TH
12
Show member pathways
11.23 DDC MAOA MAOB
13
Show member pathways
11.19 ACHE DBH MAOA TH
14 11.16 MAOB SNCA TH
15
Show member pathways
11.02 ACHE MAOA
16
Show member pathways
10.72 MAOA MAOB
17
Show member pathways
10.68 MAOA MAOB
18 10.58 ACHE DDC TH
19 10.4 DDC MAOA MAOB TH
20
Show member pathways
10.36 ACHE DBH DDC MAOA TH

GO Terms for Pure Autonomic Failure

Cellular components related to Pure Autonomic Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ACE ACHE DBH EPO NPPA REN
2 synaptic vesicle GO:0008021 9.33 DDC SNCA TH
3 extracellular space GO:0005615 9.23 ACE ACHE DBH EPO NPPA REN

Biological processes related to Pure Autonomic Failure according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 MAOB REN SNCA TH
2 response to lipopolysaccharide GO:0032496 9.77 EPO MAOB REN SNCA TH
3 cellular response to drug GO:0035690 9.69 DDC REN TH
4 response to amphetamine GO:0001975 9.63 DBH TH
5 response to immobilization stress GO:0035902 9.62 REN TH
6 positive regulation of endocytosis GO:0045807 9.62 NEDD4L SNCA
7 regulation of blood pressure GO:0008217 9.62 ACE GNB3 NPPA REN
8 synaptic transmission, dopaminergic GO:0001963 9.61 SNCA TH
9 response to metal ion GO:0010038 9.6 NEDD4L TH
10 multicellular organism aging GO:0010259 9.59 DDC TH
11 response to corticosterone GO:0051412 9.58 MAOB TH
12 beta-amyloid metabolic process GO:0050435 9.57 ACE REN
13 neurotransmitter biosynthetic process GO:0042136 9.56 ACHE TH
14 angiotensin maturation GO:0002003 9.55 ACE REN
15 cellular response to alkaloid GO:0071312 9.54 DDC TH
16 response to salt stress GO:0009651 9.52 EPO TH
17 norepinephrine biosynthetic process GO:0042421 9.49 DBH TH
18 response to pyrethroid GO:0046684 9.48 DDC TH
19 aminergic neurotransmitter loading into synaptic vesicle GO:0015842 9.46 DDC TH
20 isoquinoline alkaloid metabolic process GO:0033076 9.43 DDC TH
21 neurotransmitter catabolic process GO:0042135 9.43 ACHE MAOA MAOB
22 phytoalexin metabolic process GO:0052314 9.4 DDC TH
23 dopamine biosynthetic process GO:0042416 9.33 DDC SNCA TH
24 dopamine catabolic process GO:0042420 9.13 DBH MAOA MAOB
25 catecholamine biosynthetic process GO:0042423 8.8 DBH DDC TH
26 oxidation-reduction process GO:0055114 10.01 DBH MAOA MAOB SNCA TH

Molecular functions related to Pure Autonomic Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.35 DBH MAOA MAOB SNCA TH
2 hormone activity GO:0005179 9.33 EPO NPPA TTR
3 ferrous iron binding GO:0008198 9.32 SNCA TH
4 amino acid binding GO:0016597 9.26 DDC TH
5 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB

Sources for Pure Autonomic Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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