MCID: PRR002
MIFTS: 46

Pure Red-Cell Aplasia malady

Rare diseases category

Summaries for Pure Red-Cell Aplasia

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Wikipedia:63 Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors... more...

MalaCards based summary: Pure Red-Cell Aplasia, also known as pure red cell aplasia, is related to hepatitis and leukemia. An important gene associated with Pure Red-Cell Aplasia is EPO (erythropoietin), and among its related pathways are Paxillin-dependent events mediated by a4b1 and G protein signaling K RAS regulation pathway. The drug cyclophosphamide and the compounds erex and nesp have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells.

Aliases & Classifications for Pure Red-Cell Aplasia

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Pure Red-Cell Aplasia, Aliases & Descriptions:

Name: Pure Red-Cell Aplasia 9 11 60
Pure Red Cell Aplasia 9 41
Primary Red Cell Aplasia 9
 
Red-Cell Aplasia Pure 43
Red Cell Hypoplasia 9
Prca 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:1340
NCIt38 C34974
MeSH33 D012010

Related Diseases for Pure Red-Cell Aplasia

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Diseases related to Pure Red-Cell Aplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3HLA-A, HLA-DRB1, ALB
2leukemia31.2HLA-A, HLA-DRB1, EPOR, EPO, IL2RA
3systemic lupus erythematosus31.2HLA-A, HLA-DRB1, IL2RA
4myelofibrosis31.0TIMP1, EPO
5thyroiditis30.9HLA-DRB1
6hepatitis c30.9HLA-A, HLA-DRB1, ALB
7myeloma30.9EPOR, EPO, ALB
8leprosy30.9HLA-DRB1
9diamond-blackfan anemia30.7RPL23A, RPL35, RPL39, EPO
10lung cancer30.5SYP, CHGA, TIMP1
11arthritis30.5ALB, TIMP1, HLA-DRB1, HLA-A
12rheumatoid arthritis30.5IL2RA, TIMP1, HLA-DRB1, HLA-A
13breast cancer30.4TIMP1, EPOR, CHGA, SYP
14connective tissue disease30.1HLA-A, HLA-DRB1, IL2RA, ALB
15tuberculosis30.1HLA-A, HLA-DRB1, IL2RA, ALB
16acquired pure red cell aplasia11.1
17thymoma11.1
18lupus erythematosus10.9
19hemolytic anemia10.9
20autoimmune hemolytic anemia10.9
21large granular lymphocyte leukemia10.9
22chronic lymphocytic leukemia10.8
23hematopoietic stem cell transplantation10.8
24myelodysplastic syndrome10.7
25transient erythroblastopenia of childhood10.7
26myasthenia gravis10.7
27thrombocytopenia10.7
28hepatitis a10.7
29aplastic anemia10.6
30b-cell lymphomas10.6
31kidney disease10.6
32neuroblastoma10.5SYP
33dysembryoplastic neuroepithelial tumor10.5SYP
34diffuse large b-cell lymphoma10.5
35good syndrome10.5
36adult-onset still's disease10.5
37peritonitis10.5
38purpura10.5
39viral hepatitis10.5
40angioimmunoblastic t-cell lymphoma10.5
41chronic graft versus host disease10.5
42acquired polycythemia10.4EPO, EPOR
43primary polycythemia10.4EPOR, EPO
44hepatitis c virus10.4
45celiac disease10.4
46angioimmunoblastic lymphadenopathy with dysproteinemia10.4
47neutropenia10.4
48evans' syndrome10.4
49antiphospholipid syndrome10.4
50enterocele10.4

Graphical network of the top 20 diseases related to Pure Red-Cell Aplasia:



Diseases related to pure red-cell aplasia

Symptoms for Pure Red-Cell Aplasia

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Drugs & Therapeutics for Pure Red-Cell Aplasia

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Drug clinical trials:

Search ClinicalTrials for Pure Red-Cell Aplasia

Search NIH Clinical Center for Pure Red-Cell Aplasia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pure Red-Cell Aplasia

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Anatomical Context for Pure Red-Cell Aplasia

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MalaCards organs/tissues related to Pure Red-Cell Aplasia:

31
Bone, Bone marrow, T cells, B cells, Kidney, Myeloid, Thymus, Liver, Heart, Brain, Lung, Pancreas, Thyroid, Breast, Skin, Prostate, Testes, Endothelial

Animal Models for Pure Red-Cell Aplasia or affiliated genes

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Publications for Pure Red-Cell Aplasia

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Articles related to Pure Red-Cell Aplasia:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Oral High Dose Dexamethasone for Pure Red Cell Aplasia Following ABO-Mismatched Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report. (25825583)
2015
2
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
3
Pure red cell aplasia: a rare complication of isoniazid therapy. (25332529)
2014
4
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. (25361796)
2014
5
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. (25096221)
2014
6
Pure red cell aplasia complicating chronic lymphocytic leukemia: rapid response to high-dose methylprednisolone and rituximab. (23480495)
2013
7
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
8
Reversible pure red cell aplasia of pregnancy: a therapeutic challenge. (24431622)
2013
9
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
10
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
11
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
12
Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. (21654161)
2011
13
Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation. (18769919)
2009
14
Acquired pure red cell aplasia: updated review of treatment. (18510682)
2008
15
Spectrum of pure red cell aplasia in adult population of north-west India. (18616874)
2008
16
Epoetin-induced pure red cell aplasia: diagnosis and treatment. (18089975)
2007
17
Thirty-nine cases of pure red cell aplasia: a single center experience from India. (17558701)
2007
18
Treatment of resistant pure red cell aplasia after major ABO-incompatible bone marrow transplantation with human adipose tissue-derived mesenchymal stem cells. (17573692)
2007
19
Pure red cell aplasia in a patient of chronic granulocyte leukemia associated with imatinib. (17123082)
2007
20
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
21
Epoetin-induced pure red cell aplasia successfully treated with androgens. (16736425)
2006
22
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
23
Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy. (16313965)
2006
24
Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia. (16111536)
2005
25
Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project. (16099877)
2005
26
Pure red cell aplasia and myelofibrosis in B-cell neoplasm. (16104450)
2005
27
Effect of tacrolimus in a patient with pure red-cell aplasia. (15686511)
2005
28
Antierythropoietin antibody-induced pure red cell aplasia: posttransplant evolution. (15138876)
2004
29
Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia. (15252175)
2004
30
Pure red cell aplasia following pegylated interferon alpha treatment. (15465516)
2004
31
Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion. (15522068)
2004
32
Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia. (15384028)
2004
33
Pure red cell aplasia in patients with refractory anaemia treated with two different recombinant erythropoietins. (15009075)
2004
34
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
35
A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. (12132531)
2002
36
Non-Hodgkin's lymphoma with pure red cell aplasia. (11868873)
2001
37
Th1/Th2 LYMPHOCYTE SUBSETS IN PURE RED CELL APLASIA (10233443)
1999
38
Tuberculosis pure red cell aplasia. (10206512)
1999
39
A patient with pure red cell aplasia and Good's syndrome. (10553168)
1999
40
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
41
Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity. (9609530)
1998
42
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
43
Response to cyclosporin A and recombinant human erythropoietin in a case of B cell chronic lymphocytic leukemia and pure red cell aplasia. (8709652)
1996
44
Pure red cell aplasia: an unusual association with invasive thymoma. (10999075)
1996
45
IL-3 increases marrow and peripheral erythroid precursors in chronic pure red cell aplasia presenting in childhood. (7873394)
1995
46
Steroid-resistant acquired pure red cell aplasia: a partial remission induced by recombinant human erythropoietin. (1911372)
1991
47
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
48
Remission of acquired pure red cell aplasia following plasma exchanges. (3918338)
1985
49
Electron microscopic demonstration of IgG antibodies directed to erythroblast in primary acquired pure red cell aplasia. (6448720)
1980
50
Therapeutic considerations in acquired pure red cell aplasia in adults. (6051100)
1967

Variations for Pure Red-Cell Aplasia

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Expression for genes affiliated with Pure Red-Cell Aplasia

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Search GEO for disease gene expression data for Pure Red-Cell Aplasia.

Pathways for genes affiliated with Pure Red-Cell Aplasia

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Pathways related to Pure Red-Cell Aplasia according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b736
a4b1 and a4b7 Integrin signaling36
9.9EPOR, EPO
29.9EPO, EPOR
39.7IL2RA, HLA-DRB1
4
Show member pathways
Type III interferon signaling36
9.6IL2RA, EPO, EPOR
5
Show member pathways
9.3HLA-A, HLA-DRB1, EPOR
6
Show member pathways
9.3IL2RA, HLA-DRB1, HLA-A
7
Show member pathways
9.3IL2RA, HLA-DRB1, HLA-A
89.3IL2RA, HLA-DRB1, HLA-A
9
Show member pathways
9.3HLA-A, HLA-DRB1, IL2RA
10
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.3HLA-A, HLA-DRB1, IL2RA
11
Show member pathways
9.2IL2RA, EPO, EPOR, TIMP1
12
Show member pathways
9.2TIMP1, EPOR, EPO, IL2RA
139.1IL2RA, EPO, EPOR, HLA-DRB1
14
Show member pathways
9.0HLA-DRB1, TIMP1, EPOR, IL2RA
15
Show member pathways
8.5RPL39, RPL35, RPL23A
16
Show member pathways
Cytoplasmic Ribosomal Proteins36
8.5RPL39, RPL35, RPL23A

Compounds for genes affiliated with Pure Red-Cell Aplasia

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Compounds related to Pure Red-Cell Aplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1erex4310.3EPOR, EPO
2nesp4310.3EPO, EPOR
3pp 1004310.2EPOR, EPO
4smcc4310.2CHGA, SYP
5pimonidazole4310.2EPOR, EPO
6111in-pentetreotide4310.1CHGA, SYP
7eprex4310.1EPO, ALB
8uva 14310.1TIMP1, IL2RA
9midodrine43 1211.0EPO, ALB
10s 1004310.0SYP, CHGA
11dr-104310.0HLA-A, HLA-DRB1
12tween 804310.0EPO, ALB
13methylcellulose439.9TIMP1, EPOR, EPO
14indoxyl sulfate439.9TIMP1, ALB
15theophylline43 28 24 1212.9IL2RA, CHGA, EPO
16bismuth43 2410.9IL2RA, ALB
17streptozotocin439.9SYP, CHGA, TIMP1
18bleomycin43 1210.8TIMP1, EPO, IL2RA
19polysulfone439.8ALB, IL2RA, EPO
20pixy321439.7EPO, TIMP1
21mycophenolate mofetil43 49 1211.7ALB, IL2RA, EPO
22azathioprine43 2 49 1212.7IL2RA, EPO, TIMP1
23vitamin b12439.7ALB, EPO, TIMP1
24gp 130439.6IL2RA, EPO, EPOR, TIMP1
25lenalidomide43 1210.6EPO, EPOR
26etoposide43 49 59 1212.5SYP, IL2RA, CHGA, TIMP1
27phorbol439.5TIMP1, CHGA, IL2RA
28norepinephrine43 24 1211.5TIMP1, CHGA, IL2RA, SYP
29p002439.5HLA-A, TIMP1, CHGA
30alpha tocopherol439.5TIMP1, IL2RA, ALB
31nifedipine43 28 49 1212.4IL2RA, CHGA, TIMP1
32folate439.4TIMP1, EPO, IL2RA, ALB
33calcitriol43 59 24 1212.4ALB, IL2RA, EPO, TIMP1
34paraffin439.3TIMP1, EPOR, CHGA, IL2RA, SYP
35cyclosporin a43 28 5911.3IL2RA, EPO, TIMP1, HLA-A
36creatinine439.1EPO, CHGA, IL2RA, SYP, ALB
37testosterone43 59 24 1212.1EPO, CHGA, IL2RA, SYP, ALB
38vitamin d439.1TIMP1, EPO, CHGA, IL2RA, ALB
39histamine43 28 2411.1TIMP1, CHGA, IL2RA, SYP, ALB
40cisplatin43 49 59 1212.0TIMP1, EPOR, EPO, CHGA, IL2RA, SYP
41vegf439.0TIMP1, EPOR, EPO, CHGA, IL2RA, SYP
42estrogen439.0TIMP1, EPOR, CHGA, IL2RA, SYP
43tacrolimus43 49 1211.0ALB, IL2RA, EPOR, TIMP1, HLA-A
44lactate439.0TIMP1, EPO, CHGA, ALB
45methotrexate49 43 1211.0HLA-DRB1, TIMP1, EPO, IL2RA, ALB
46glutamate438.8HLA-DRB1, TIMP1, EPOR, CHGA, IL2RA, SYP
47alanine438.8ALB, EPOR, TIMP1, HLA-DRB1, HLA-A
48cysteine438.7TIMP1, EPOR, CHGA, IL2RA, SYP, ALB
49arginine438.7HLA-A, HLA-DRB1, TIMP1, EPOR, CHGA, IL2RA
50tyrosine438.2HLA-A, HLA-DRB1, TIMP1, EPOR, EPO, CHGA

GO Terms for genes affiliated with Pure Red-Cell Aplasia

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Cellular components related to Pure Red-Cell Aplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.7HLA-DRB1, HLA-A
2transport vesicle membraneGO:00306589.6CHGA, HLA-DRB1
3platelet alpha granule lumenGO:00310939.6ALB, TIMP1
4ER to Golgi transport vesicle membraneGO:00125079.3HLA-DRB1, HLA-A
5extracellular regionGO:00055768.7TIMP1, EPOR, EPO, CHGA, ALB
6cytosolic large ribosomal subunitGO:00226258.6RPL23A, RPL35, RPL39

Biological processes related to Pure Red-Cell Aplasia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte maturationGO:004324910.0TIMP1, EPO
2inflammatory response to antigenic stimulusGO:00024379.8IL2RA, HLA-DRB1
3detection of bacteriumGO:00160459.7HLA-DRB1, HLA-A
4negative regulation of T cell proliferationGO:00421309.6IL2RA, HLA-DRB1
5viral transcriptionGO:00190838.8RPL23A, RPL35, RPL39
6translational terminationGO:00064158.8RPL39, RPL35, RPL23A
7translational elongationGO:00064148.8RPL23A, RPL35, RPL39
8SRP-dependent cotranslational protein targeting to membraneGO:00066148.8RPL39, RPL35, RPL23A
9viral life cycleGO:00190588.7RPL23A, RPL35, RPL39
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001848.7RPL39, RPL35, RPL23A
11translational initiationGO:00064138.7RPL23A, RPL35, RPL39
12mRNA metabolic processGO:00160718.5RPL39, RPL35, RPL23A
13translationGO:00064128.5RPL23A, RPL35, RPL39
14RNA metabolic processGO:00160708.2RPL23A, RPL35, RPL39
15viral processGO:00160328.2HLA-A, RPL39, RPL35, RPL23A

Molecular functions related to Pure Red-Cell Aplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DRB1, HLA-A
2structural constituent of ribosomeGO:00037358.2RPL23A, RPL35, RPL39

Products for genes affiliated with Pure Red-Cell Aplasia

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Sources for Pure Red-Cell Aplasia

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3CDC
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
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42NINDS
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
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61UMLS via Orphanet