PRCA
MCID: PRR002
MIFTS: 56

Pure Red-Cell Aplasia (PRCA) malady

Rare diseases, Blood diseases categories
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Summaries for Pure Red-Cell Aplasia

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Wikipedia:65 Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors... more...

MalaCards based summary: Pure Red-Cell Aplasia, also known as primary red cell aplasia, is related to hepatitis and leukemia. An important gene associated with Pure Red-Cell Aplasia is EPO (erythropoietin), and among its related pathways are Paxillin-dependent events mediated by a4b1 and G protein signaling K RAS regulation pathway. The drug cyclophosphamide and the compounds erex and nesp have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells.

Aliases & Classifications for Pure Red-Cell Aplasia

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Pure Red-Cell Aplasia, Aliases & Descriptions:

Name: Pure Red-Cell Aplasia 8 10 62
Primary Red Cell Aplasia 8 62
Pure Red Cell Aplasia 8 42
 
Red-Cell Aplasia Pure 44
Red Cell Hypoplasia 8
Prca 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:1340
NCIt39 C34974
MeSH34 D012010

Related Diseases for Pure Red-Cell Aplasia

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Diseases related to Pure Red-Cell Aplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3HLA-A, HLA-DRB1, ALB
2leukemia31.2HLA-DRB1, EPOR, EPO, HLA-A, IL2RA
3systemic lupus erythematosus31.2IL2RA, HLA-DRB1, HLA-A
4myelofibrosis31.1EPO, TIMP1
5thyroiditis30.9HLA-DRB1
6hepatitis c30.9ALB, HLA-DRB1, HLA-A
7leprosy30.9HLA-DRB1
8graft versus host disease30.9IL2RA, HLA-A, HLA-DRB1
9myeloma30.8ALB, EPO, EPOR
10lung cancer30.6CHGA, SYP, TIMP1
11arthritis30.6HLA-DRB1, TIMP1, ALB, HLA-A
12rheumatoid arthritis30.5HLA-DRB1, TIMP1, IL2RA, HLA-A
13diamond-blackfan anemia 130.5RPL23A, RPL35, RPL39, EPO
14breast cancer30.5SYP, EPOR, TIMP1, CHGA
15non-hodgkin lymphoma30.4HLA-A, HLA-DRB1, IL2RA
16connective tissue disease30.1HLA-DRB1, ALB, HLA-A, IL2RA
17tuberculosis30.1HLA-A, HLA-DRB1, ALB, IL2RA
18acquired pure red cell aplasia11.2
19thymoma11.1
20lupus erythematosus10.9
21hemolytic anemia10.9
22autoimmune hemolytic anemia10.8
23large granular lymphocyte leukemia10.8
24chronic lymphocytic leukemia10.8
25hematopoietic stem cell transplantation10.8
26myelodysplastic syndromes10.8
27transient erythroblastopenia of childhood10.7
28myasthenia gravis10.7
29thrombocytopenia10.7
30hepatitis a10.7
31aplastic anemia10.6
32b-cell lymphomas10.6
33diamond-blackfan anemia10.6
34kidney disease10.6
35neuroblastoma10.5SYP
36diffuse large b-cell lymphoma10.5
37adult-onset still's disease10.5
38good syndrome10.5
39peritonitis10.5
40purpura10.5
41viral hepatitis10.5
42angioimmunoblastic t-cell lymphoma10.5
43chronic graft versus host disease10.5
44dysembryoplastic neuroepithelial tumor10.5SYP
45acquired polycythemia10.4EPO, EPOR
46primary polycythemia10.4EPO, EPOR
47angioimmunoblastic lymphadenopathy with dysproteinemia10.4
48celiac disease10.4
49hodgkin's lymphoma10.4
50neutropenia10.4

Graphical network of the top 20 diseases related to Pure Red-Cell Aplasia:



Diseases related to pure red-cell aplasia

Symptoms for Pure Red-Cell Aplasia

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Drugs & Therapeutics for Pure Red-Cell Aplasia

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Drug clinical trials:

Search ClinicalTrials for Pure Red-Cell Aplasia

Search NIH Clinical Center for Pure Red-Cell Aplasia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pure Red-Cell Aplasia

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Anatomical Context for Pure Red-Cell Aplasia

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MalaCards organs/tissues related to Pure Red-Cell Aplasia:

32
Bone, Bone marrow, T cells, B cells, Kidney, Myeloid, Thymus, Liver, Heart, Brain, Lung, Pancreas, Thyroid, Breast, Skin, Prostate, Testes, Endothelial

Animal Models for Pure Red-Cell Aplasia or affiliated genes

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Publications for Pure Red-Cell Aplasia

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Articles related to Pure Red-Cell Aplasia:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
2
Pure red cell aplasia: a rare complication of isoniazid therapy. (25332529)
2014
3
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. (25361796)
2014
4
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. (25096221)
2014
5
Pure red cell aplasia complicating chronic lymphocytic leukemia: rapid response to high-dose methylprednisolone and rituximab. (23480495)
2013
6
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
7
Reversible pure red cell aplasia of pregnancy: a therapeutic challenge. (24431622)
2013
8
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
9
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
10
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
11
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
12
Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. (21654161)
2011
13
Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation. (18769919)
2009
14
Acquired pure red cell aplasia: updated review of treatment. (18510682)
2008
15
Spectrum of pure red cell aplasia in adult population of north-west India. (18616874)
2008
16
Epoetin-induced pure red cell aplasia: diagnosis and treatment. (18089975)
2007
17
Thirty-nine cases of pure red cell aplasia: a single center experience from India. (17558701)
2007
18
Treatment of resistant pure red cell aplasia after major ABO-incompatible bone marrow transplantation with human adipose tissue-derived mesenchymal stem cells. (17573692)
2007
19
Pure red cell aplasia in a patient of chronic granulocyte leukemia associated with imatinib. (17123082)
2007
20
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
21
Epoetin-induced pure red cell aplasia successfully treated with androgens. (16736425)
2006
22
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
23
Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy. (16313965)
2006
24
Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia. (16111536)
2005
25
Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project. (16099877)
2005
26
Pure red cell aplasia and myelofibrosis in B-cell neoplasm. (16104450)
2005
27
Effect of tacrolimus in a patient with pure red-cell aplasia. (15686511)
2005
28
Antierythropoietin antibody-induced pure red cell aplasia: posttransplant evolution. (15138876)
2004
29
Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia. (15252175)
2004
30
Pure red cell aplasia following pegylated interferon alpha treatment. (15465516)
2004
31
Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion. (15522068)
2004
32
Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia. (15384028)
2004
33
Pure red cell aplasia in patients with refractory anaemia treated with two different recombinant erythropoietins. (15009075)
2004
34
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
35
A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. (12132531)
2002
36
Non-Hodgkin's lymphoma with pure red cell aplasia. (11868873)
2001
37
Th1/Th2 LYMPHOCYTE SUBSETS IN PURE RED CELL APLASIA (10233443)
1999
38
Tuberculosis pure red cell aplasia. (10206512)
1999
39
A patient with pure red cell aplasia and Good's syndrome. (10553168)
1999
40
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
41
Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity. (9609530)
1998
42
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
43
Response to cyclosporin A and recombinant human erythropoietin in a case of B cell chronic lymphocytic leukemia and pure red cell aplasia. (8709652)
1996
44
Pure red cell aplasia: an unusual association with invasive thymoma. (10999075)
1996
45
IL-3 increases marrow and peripheral erythroid precursors in chronic pure red cell aplasia presenting in childhood. (7873394)
1995
46
Steroid-resistant acquired pure red cell aplasia: a partial remission induced by recombinant human erythropoietin. (1911372)
1991
47
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
48
Remission of acquired pure red cell aplasia following plasma exchanges. (3918338)
1985
49
Electron microscopic demonstration of IgG antibodies directed to erythroblast in primary acquired pure red cell aplasia. (6448720)
1980
50
Therapeutic considerations in acquired pure red cell aplasia in adults. (6051100)
1967

Variations for Pure Red-Cell Aplasia

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Expression for genes affiliated with Pure Red-Cell Aplasia

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Expression patterns in normal tissues for genes affiliated with Pure Red-Cell Aplasia

Search GEO for disease gene expression data for Pure Red-Cell Aplasia.

Pathways for genes affiliated with Pure Red-Cell Aplasia

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Pathways related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b737
a4b1 and a4b7 Integrin signaling37
9.9EPOR, EPO
29.9EPO, EPOR
39.7IL2RA, HLA-DRB1
4
Show member pathways
Type III interferon signaling37
9.6EPO, IL2RA, EPOR
5
Show member pathways
9.3EPOR, HLA-DRB1, HLA-A
6
Show member pathways
9.3IL2RA, HLA-DRB1, HLA-A
7
Show member pathways
9.3IL2RA, HLA-A, HLA-DRB1
8
Show member pathways
9.3HLA-A, HLA-DRB1, IL2RA
9
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3IL2RA, HLA-DRB1, HLA-A
109.3HLA-DRB1, IL2RA, HLA-A
11
Show member pathways
9.2EPOR, TIMP1, IL2RA, EPO
12
Show member pathways
9.2TIMP1, EPO, EPOR, IL2RA
139.1IL2RA, EPO, EPOR, HLA-DRB1
14
Show member pathways
9.0IL2RA, EPOR, TIMP1, HLA-DRB1
15
Show member pathways
Cytoplasmic Ribosomal Proteins37
8.5RPL23A, RPL39, RPL35
16
Show member pathways
8.5RPL39, RPL35, RPL23A

Compounds for genes affiliated with Pure Red-Cell Aplasia

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Compounds related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1erex4410.3EPOR, EPO
2nesp4410.3EPOR, EPO
3pp 1004410.2EPO, EPOR
4smcc4410.2SYP, CHGA
5pimonidazole4410.2EPOR, EPO
6111in-pentetreotide4410.1CHGA, SYP
7eprex4410.1ALB, EPO
8s 1004410.0CHGA, SYP
9midodrine44 1111.0ALB, EPO
10uva 14410.0TIMP1, IL2RA
11dr-104410.0HLA-DRB1, HLA-A
12tween 804410.0ALB, EPO
13methylcellulose449.9EPO, TIMP1, EPOR
14indoxyl sulfate449.9TIMP1, ALB
15bismuth44 2410.9ALB, IL2RA
16theophylline44 28 24 1112.9IL2RA, EPO, CHGA
17streptozotocin449.9CHGA, SYP, TIMP1
18bleomycin44 1110.8IL2RA, EPO, TIMP1
19polysulfone449.8IL2RA, EPO, ALB
20pixy321449.7EPO, TIMP1
21mycophenolate mofetil44 50 1111.7IL2RA, ALB, EPO
22azathioprine44 2 50 1112.7IL2RA, TIMP1, EPO
23vitamin b12449.7ALB, TIMP1, EPO
24gp 130449.6EPO, IL2RA, TIMP1, EPOR
25lenalidomide44 1110.6EPOR, EPO
26phorbol449.5TIMP1, CHGA, IL2RA
27etoposide44 50 61 1112.5IL2RA, CHGA, TIMP1, SYP
28norepinephrine44 24 1111.5SYP, IL2RA, CHGA, TIMP1
29alpha tocopherol449.5TIMP1, IL2RA, ALB
30p002449.4HLA-A, TIMP1, CHGA
31nifedipine44 28 50 1112.4IL2RA, CHGA, TIMP1
32folate449.4EPO, ALB, IL2RA, TIMP1
33calcitriol44 61 24 1112.4TIMP1, IL2RA, ALB, EPO
34paraffin449.3CHGA, EPOR, TIMP1, IL2RA, SYP
35cyclosporin a44 28 6111.3IL2RA, EPO, HLA-A, TIMP1
36creatinine449.1ALB, IL2RA, CHGA, SYP, EPO
37testosterone44 61 24 1112.1IL2RA, EPO, SYP, ALB, CHGA
38vitamin d449.1TIMP1, EPO, ALB, IL2RA, CHGA
39histamine44 28 2411.1TIMP1, CHGA, IL2RA, SYP, ALB
40cisplatin44 50 61 1112.0SYP, TIMP1, EPOR, EPO, CHGA, IL2RA
41vegf449.0IL2RA, TIMP1, EPOR, EPO, SYP, CHGA
42estrogen449.0TIMP1, SYP, EPOR, CHGA, IL2RA
43tacrolimus44 50 1111.0IL2RA, EPOR, HLA-A, TIMP1, ALB
44lactate449.0TIMP1, CHGA, ALB, EPO
45methotrexate50 44 1111.0TIMP1, ALB, EPO, HLA-DRB1, IL2RA
46glutamate448.8CHGA, SYP, IL2RA, HLA-DRB1, TIMP1, EPOR
47alanine448.8EPOR, ALB, TIMP1, HLA-DRB1, HLA-A
48cysteine448.7EPOR, TIMP1, IL2RA, SYP, ALB, CHGA
49arginine448.7IL2RA, EPOR, CHGA, TIMP1, HLA-A, HLA-DRB1
50tyrosine448.2IL2RA, EPO, EPOR, HLA-DRB1, TIMP1, HLA-A

GO Terms for genes affiliated with Pure Red-Cell Aplasia

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Cellular components related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-A
2transport vesicle membraneGO:0306589.6CHGA, HLA-DRB1
3platelet alpha granule lumenGO:0310939.6ALB, TIMP1
4ER to Golgi transport vesicle membraneGO:0125079.3HLA-DRB1, HLA-A
5extracellular regionGO:0055768.7TIMP1, EPOR, EPO, CHGA, ALB
6cytosolic large ribosomal subunitGO:0226258.6RPL23A, RPL35, RPL39

Biological processes related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte maturationGO:04324910.0TIMP1, EPO
2inflammatory response to antigenic stimulusGO:0024379.8IL2RA, HLA-DRB1
3detection of bacteriumGO:0160459.7HLA-DRB1, HLA-A
4negative regulation of T cell proliferationGO:0421309.6IL2RA, HLA-DRB1
5viral transcriptionGO:0190838.8RPL23A, RPL35, RPL39
6translational terminationGO:0064158.8RPL39, RPL35, RPL23A
7translational elongationGO:0064148.8RPL23A, RPL35, RPL39
8SRP-dependent cotranslational protein targeting to membraneGO:0066148.8RPL39, RPL35, RPL23A
9viral life cycleGO:0190588.7RPL23A, RPL35, RPL39
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001848.7RPL39, RPL35, RPL23A
11translational initiationGO:0064138.7RPL23A, RPL35, RPL39
12mRNA metabolic processGO:0160718.5RPL39, RPL35, RPL23A
13translationGO:0064128.5RPL23A, RPL35, RPL39
14RNA metabolic processGO:0160708.2RPL23A, RPL35, RPL39
15viral processGO:0160328.2HLA-A, RPL39, RPL35, RPL23A

Molecular functions related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-A
2structural constituent of ribosomeGO:0037358.2RPL23A, RPL35, RPL39

Products for genes affiliated with Pure Red-Cell Aplasia

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Sources for Pure Red-Cell Aplasia

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3CDC
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25ICD10
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