PRCA
MCID: PRR002
MIFTS: 54

Pure Red-Cell Aplasia (PRCA) malady

Summaries for Pure Red-Cell Aplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors... more...

MalaCards: Pure Red-Cell Aplasia, also known as pure red cell aplasia, is related to leukemia and hepatitis. An important gene associated with Pure Red-Cell Aplasia is EPO (erythropoietin), and among its related pathways are Hematopoietic cell lineage and Translation initiation complex formation. The drug cyclophosphamide and the compounds norepinephrine and ethanolamine oleate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotype hematopoietic system.

Aliases & Classifications for Pure Red-Cell Aplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

pure red-cell aplasia 8 10 60
pure red cell aplasia 8 42
primary red cell aplasia 8
red-cell aplasia pure 44
red cell hypoplasia 8
prca 42


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Disease Ontology8 DOID:1340
NCIt39 C34974
MeSH34 D012010

Related Diseases for Pure Red-Cell Aplasia

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17GeneCards, 18GeneDecks
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Diseases related to Pure Red-Cell Aplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5GZMB, IL2RA, HP, EPO, CD40LG, OXA1L
2hepatitis31.3GZMB, CD40LG, F2, HP
3lupus erythematosus31.3F2, CD40LG
4systemic lupus erythematosus31.2OXA1L, CD40LG, IL2RA, F2
5autoimmune hemolytic anemia31.1CD40LG, HP
6hepatitis a31.0F2
7hepatitis c31.0CD40LG, F2, HP
8aplastic anemia30.8IL3, EPO, GZMB, RPS19
9thrombocytopenia30.8PIK3C2A, F2, CD40LG, EPO, HP, IL3
10arthritis30.8RPS19, HP, GZMB
11graft versus host disease30.8GZMB, IL3, IL2RA
12peritonitis30.7F2
13viral hepatitis30.7F2
14diamond-blackfan anemia30.7RPS19, EPO, IL3
15rheumatoid arthritis30.7HP, IL2RA, GZMB, OXA1L, RPS19, CD40LG
16pneumonia30.5PIK3C2A, OXA1L
17neutropenia30.5OXA1L, EPO, IL3, GZMB
18myeloma30.5CD40LG, IL3, EPO, OXA1L
19myelofibrosis30.5IL3, EPO
20antiphospholipid syndrome30.5CD40LG, F2
21celiac disease30.3GZMB
22hypothyroidism30.3PIK3C2A
23hypertension30.3F2
24lung cancer30.3SYP, CHGA
25cryoglobulinemia30.3CD40LG
26hepatitis e30.3CD40LG
27breast cancer30.3OXA1L, GZMB, RPS19
28prostate cancer30.3CHGA, OXA1L, GZMB
29disseminated intravascular coagulation30.3F2, PIK3C2A
30connective tissue disease30.3CD40LG, IL2RA, F2
31diamond-blackfan anemia 130.3RPL36, RPL35, RPL39, IL3, EPO, RPL35A
32thymoma11.0
33chronic lymphocytic leukemia10.8
34hemolytic anemia10.8
35acquired pure red cell aplasia10.8
36myasthenia gravis10.6
37transient erythroblastopenia of childhood10.6
38kidney disease10.5
39good syndrome10.5
40adult-onset still's disease10.5
41diffuse large b-cell lymphoma10.5
42acute leukemia10.5
43purpura10.5
44t-cell leukemia10.5
45enterocele10.4
46evans' syndrome10.4
47acquired thrombocytopenia10.4
48macroglobulinemia10.4
49autoimmune hepatitis10.4
50t-cell large granular lymphocyte leukemia10.4

Graphical network of the top 20 diseases related to Pure Red-Cell Aplasia:



Diseases related to pure red-cell aplasia

Clinical Features for Pure Red-Cell Aplasia

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Drugs & Therapeutics for Pure Red-Cell Aplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pure Red-Cell Aplasia

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Anatomical Context for Pure Red-Cell Aplasia

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32MalaCards
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MalaCards organs/tissues related to Pure Red-Cell Aplasia:

32
Bone, Bone marrow, T cells, B cells, Kidney, Myeloid, Liver, Thymus, Heart, Endothelial, Pancreas, Breast, Thyroid, Testes, Lung, Brain, Skin, Prostate

Animal Models for Pure Red-Cell Aplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pure Red-Cell Aplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3F2, IL3, IL2RA, HP, EPO, CD40LG

Publications for Pure Red-Cell Aplasia

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50PubMed
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Articles related to Pure Red-Cell Aplasia:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
2
Reversible pure red cell aplasia of pregnancy: a therapeutic challenge. (24431622)
2013
3
Low-dose subcutaneous alemtuzumab is a safe and effective treatment for chronic acquired pure red cell aplasia. (24310664)
2013
4
Incidence and natural history of pure red cell aplasia in major ABO-mismatched haematopoietic cell transplantation. (23330820)
2013
5
Linking drugs to obscure illnesses: lessons from pure red cell aplasia, nephrogenic systemic fibrosis, and Reye's syndrome. a report from the Southern Network on Adverse Reactions (SONAR). (22692632)
2012
6
Corticosteroid treatment of pure red cell aplasia in a patient with hepatitis A. (22627171)
2012
7
Pure red cell aplasia associated with Good's syndrome accompanied by decreased stem cell factor production in the bone marrow. (20190468)
2010
8
Severe anemia caused by combination of autoimmune hemolysis, pure red cell aplasia and massive bone marrow infiltration in an elderly patient with chronic lymphocytic leukemia: successful treatment with rituximab. (20053448)
2010
9
Antiepoetin antibody-related pure red cell aplasia: successful remission with cessation of recombinant erythropoietin alone. (20652821)
2010
10
Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group. (19195037)
2009
11
Acquired pure red cell aplasia: updated review of treatment. (18510682)
2008
12
Successful therapy of chronic graft-versus-host disease manifesting as pure red cell aplasia with single-agent rituximab. (18037934)
2008
13
Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. (18641028)
2008
14
Pure red cell aplasia in a patient of chronic granulocyte leukemia associated with imatinib. (17123082)
2007
15
Pure red-cell aplasia "epidemic"--mystery completely revealed? (17556324)
2007
16
Successful treatment of pure red cell aplasia with autologous stem cell transplantation. (17546635)
2007
17
Anti-erythropoietin antibody-mediated pure red cell aplasia in a living donor liver transplant recipient treated for hepatitis C virus. (17969182)
2007
18
Autoimmune hemolytic anemias, Evans' syndromes, and pure red cell aplasia in non-Hodgkin lymphomas. (17577777)
2007
19
Impact of nonmyeloablative conditioning regimens on the occurrence of pure red cell aplasia after ABO-incompatible allogeneic haematopoietic stem cell transplantation. (17181595)
2007
20
Hematide is immunologically distinct from erythropoietin and corrects anemia induced by antierythropoietin antibodies in a rat pure red cell aplasia model. (17662888)
2007
21
Comment on "Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy" by Intalapaporn et al. (17083979)
2007
22
Pure red cell aplasia associated with concomitant use of mycophenolate mofetil and ribavirin in post-transplant recurrent hepatitis C. (16441367)
2006
23
Pure red-cell aplasia caused by the antibody to recombinant erythropoietin, epoetin-beta, in a Japanese patient with chronic renal failure. (15609276)
2005
24
Immunologic mechanisms of EPO-associated pure red cell aplasia. (15792922)
2005
25
Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid. (15565448)
2005
26
Erythropoietin-induced, antibody-mediated pure red cell aplasia. (16281965)
2005
27
Parvovirus b19 infection in HIV patient with pure red cell aplasia. (16438148)
2005
28
Simultaneous occurrence of pure red cell aplasia and papular-purpuric 'gloves and socks' syndrome in parvovirus B-19 infection. (15857471)
2005
29
Incidence of recombinant erythropoietin (EPO) hyporesponse, EPO-associated antibodies, and pure red cell aplasia in dialysis patients. (16105053)
2005
30
Erythropoietic proteins and antibody-mediated pure red cell aplasia: a potential role for micelles. (15299113)
2004
31
Successful treatment of pure red cell aplasia with plasmapheresis in a patient with systemic lupus erythematosus. (11971224)
2002
32
Pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation. (12513840)
2002
33
Acquired pure red cell aplasia in a child. (12082327)
2002
34
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation. (11535498)
2001
35
Pure red cell aplasia due to parvovirus B19 infection in a renal transplant patient: a case report. (11120017)
2000
36
Pure red cell aplasia evolving through the hyperfibrotic myelodysplastic syndrome to the acute myeloid leukemia: some pathogenetic aspects. (10193643)
1999
37
Remission of pure-red-cell aplasia associated with operative cure of lung cancer. (10367803)
1999
38
Successful treatment of acquired myelofibrosis with pure red cell aplasia by cyclosporine. (10050730)
1999
39
Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity. (9609530)
1998
40
Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia. (9482530)
1998
41
Spontaneous recovery from severe parvovirus B19 pure red cell aplasia, in a heart transplant recipient, as demonstrated by marrow culture. (9615250)
1998
42
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
43
Pure red cell aplasia during carbamazepine monotherapy. (9187483)
1997
44
Pure red cell aplasia in systemic lupus erythematosus. (19078027)
1996
45
Azathioprine-induced pure red-cell aplasia. (8672045)
1996
46
Pure red-cell aplasia requiring cytotoxic chemotherapy: presence of clonal T-lymphocytes without characteristics of chronic lymphocytic leukemia. (8892747)
1996
47
Acquired idiopathic pure red cell aplasia in a hemodialyzed patient with inactive systemic lupus erythematosus. (7803918)
1994
48
Pure red cell aplasia following pernicious anemia. (2105636)
1990
49
Acquired pure red cell aplasia: case report of a patient responding to prednisone. (7160328)
1982
50
Corticosteroid-responsive acquired pure red cell aplasia in adults. (6054841)
1967

Genetic Variations for Pure Red-Cell Aplasia

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Expression for genes affiliated with Pure Red-Cell Aplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pure Red-Cell Aplasia

Search GEO for disease gene expression data for Pure Red-Cell Aplasia.

Pathways for genes affiliated with Pure Red-Cell Aplasia

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL3, IL2RA, EPO
2
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10.1RPS21, RPS17, RPS19
3
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10.1CD40LG, IL2RA, IL3
4
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9.9IL3, IL2RA, CD40LG, GZMB
5
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
6
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
7
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
89.1RPL39, RPS19, RPS17, RPL27, RPL36, RPL35A
9
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9.0RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A

Compounds for genes affiliated with Pure Red-Cell Aplasia

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6CHGA, SYP
2ethanolamine oleate44 1111.5F2, HP
3glutamate4410.5CD40LG, PIK3C2A
4dexamethasone44 49 28 1113.5GZMB, CD40LG, IL3
5tuberculin4410.5CD40LG, IL2RA, HP
6aspartate4410.4CD40LG, F2, PIK3C2A
7ranitidine44 28 11 2413.4CHGA, CD40LG, IL2RA
8anaphylatoxin4410.4IL3, HP, RPS19
9mycophenolate mofetil44 49 1112.4IL3, IL2RA, EPO, CD40LG
10ribavirin44 49 1112.4IL3, HP, CD40LG, EPO
11carboplatin44 49 1112.4CHGA, EPO, IL3, HP
12theophylline44 28 11 2413.4CHGA, IL2RA, CD40LG, EPO
13eprex4410.3EPO, OXA1L
14glutaraldehyde4410.3CD40LG, OXA1L, SYP
15gp 1304410.3EPO, HP, IL2RA, IL3
16malondialdehyde4410.3IL2RA, HP, EPO, PIK3C2A
17sulfasalazine44 28 49 1113.3HP, IL2RA, CD40LG
18polyethylene glycol4410.3CD40LG, F2, HP, OXA1L
19neopterin4410.3IL3, IL2RA, CD40LG, GZMB, HP
20gold4410.2PIK3C2A, GZMB, SYP, CHGA
21pegfilgrastim44 1111.2IL3, EPO
22acetylcholine44 49 28 11 2414.2SYP, CHGA, CD40LG, IL2RA, IL3
23ionomycin4410.2SYP, IL2RA, IL3, CD40LG, CHGA
24etoposide44 49 59 1113.2GZMB, SYP, CHGA, IL2RA, IL3
25ivig4410.2IL3, PIK3C2A, IL2RA, GZMB, CD40LG
26heparin44 28 11 2413.2CD40LG, HP, GZMB, IL2RA, PIK3C2A
27vitamin d4410.2IL3, CHGA, EPO, HP, IL2RA
28hirudin4410.2PIK3C2A, CD40LG, F2
29citrate4410.2F2, HP, CHGA, PIK3C2A
30hyaluronic acid44 2411.2GZMB, F2, HP, CD40LG
31rapamycin4410.2IL3, CD40LG, IL2RA, GZMB, EPO
32formaldehyde44 2411.1CD40LG, SYP, CHGA, IL2RA
33aspirin44 49 28 2413.1F2, HP, IL2RA, CD40LG, OXA1L
34histamine44 28 2412.1IL3, SYP, CHGA, CD40LG, IL2RA
35thyroxine44 2411.1PIK3C2A, HP, CD40LG, OXA1L
36ascorbic acid44 2411.1PIK3C2A, CD40LG, EPO, HP, IL2RA, IL3
37epinephrine44 11 2412.0F2, IL2RA, HP, CHGA, CD40LG, PIK3C2A
38fibrinogen4410.0PIK3C2A, OXA1L, CHGA, HP, F2, CD40LG
39folate4410.0IL2RA, EPO, HP, CD40LG
40paraffin449.9IL2RA, GZMB, SYP, CD40LG, CHGA
41vegf449.9HP, EPO, CD40LG, CHGA, SYP, PIK3C2A
42cisplatin44 49 59 1112.9CD40LG, IL2RA, IL3, EPO, CHGA, SYP
43lactate449.8CHGA, F2, IL3, HP, EPO, CD40LG
44cyclosporin a44 28 5911.8PIK3C2A, EPO, F2, IL3, GZMB, HP
45testosterone44 59 11 2412.8IL2RA, PIK3C2A, SYP, CHGA, CD40LG, EPO
46steroid449.8GZMB, SYP, CHGA, HP, IL2RA, PIK3C2A
47acth449.8PIK3C2A, HP, CHGA, SYP
48cysteine449.8SYP, OXA1L, GZMB, CHGA, HP, IL2RA
49calcitriol44 59 11 2412.7IL2RA, EPO, IL3, F2
50creatinine449.5HP, PIK3C2A, SYP, CHGA, CD40LG, IL2RA

GO Terms for genes affiliated with Pure Red-Cell Aplasia

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16Gene Ontology
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Cellular components related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolic small ribosomal subunitGO:02262710.1RPS21, RPS17, RPS19
2ribosomeGO:0058409.6RPS19, RPS17, RPL27, RPL36A
3cytosolic large ribosomal subunitGO:0226259.5RPL39, RPL27, RPL36, RPL35A, RPL36A, RPL35
4cytosolGO:0058298.7RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A

Biological processes related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1rRNA processingGO:00636410.1RPL35A, RPS17, RPS19
2ribosomal small subunit biogenesisGO:04227410.1RPS21, RPS17, RPS19
3negative regulation of oxidoreductase activityGO:05135410.1OXA1L, HP
4ribosomal small subunit assemblyGO:00002810.0RPS19, RPS17
5viral transcriptionGO:0190839.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
6viral life cycleGO:0190589.4RPL39, RPS21, RPL35, RPL36A, RPS19, RPS17
7SRP-dependent cotranslational protein targeting to membraneGO:0066149.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
8translational terminationGO:0064159.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
9translational initiationGO:0064139.4RPL35A, RPL36A, RPL35, RPS21, RPL39, RPL36
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001849.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
11translational elongationGO:0064149.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL39
12mRNA metabolic processGO:0160719.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
13translationGO:0064129.3RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
14RNA metabolic processGO:0160709.3RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
15viral processGO:0160329.3RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
16gene expressionGO:0104679.2RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
17cellular protein metabolic processGO:0442679.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A

Molecular functions related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of ribosomeGO:0037359.1RPL39, RPS21, RPL35, RPL36A, RPL35A, RPL36

Products for genes affiliated with Pure Red-Cell Aplasia

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Sources for Pure Red-Cell Aplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet