PRCA
MCID: PRR002
MIFTS: 54

Pure Red-Cell Aplasia (PRCA) malady

Summaries for Pure Red-Cell Aplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors... more...

MalaCards: Pure Red-Cell Aplasia, also known as pure red cell aplasia, is related to leukemia and hepatitis. An important gene associated with Pure Red-Cell Aplasia is EPO (erythropoietin), and among its related pathways are Hematopoietic cell lineage and Translation initiation complex formation. The drug cyclophosphamide and the compounds norepinephrine and ethanolamine oleate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotype hematopoietic system.

Aliases & Classifications for Pure Red-Cell Aplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

pure red-cell aplasia 8 10 60
pure red cell aplasia 8 42
primary red cell aplasia 8
red-cell aplasia pure 44
red cell hypoplasia 8
prca 42


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Disease Ontology8 DOID:1340
NCIt39 C34974
MeSH34 D012010

Related Diseases for Pure Red-Cell Aplasia

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17GeneCards, 18GeneDecks
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Diseases related to Pure Red-Cell Aplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5GZMB, IL2RA, HP, EPO, CD40LG, OXA1L
2hepatitis31.3GZMB, CD40LG, F2, HP
3lupus erythematosus31.3F2, CD40LG
4systemic lupus erythematosus31.2OXA1L, CD40LG, IL2RA, F2
5autoimmune hemolytic anemia31.1CD40LG, HP
6hepatitis a31.0F2
7hepatitis c31.0CD40LG, F2, HP
8aplastic anemia30.8IL3, EPO, GZMB, RPS19
9thrombocytopenia30.8PIK3C2A, F2, CD40LG, EPO, HP, IL3
10arthritis30.8RPS19, HP, GZMB
11graft versus host disease30.8GZMB, IL3, IL2RA
12peritonitis30.7F2
13viral hepatitis30.7F2
14diamond-blackfan anemia30.7RPS19, EPO, IL3
15rheumatoid arthritis30.7HP, IL2RA, GZMB, OXA1L, RPS19, CD40LG
16pneumonia30.5PIK3C2A, OXA1L
17neutropenia30.5OXA1L, EPO, IL3, GZMB
18myeloma30.5CD40LG, IL3, EPO, OXA1L
19myelofibrosis30.5IL3, EPO
20antiphospholipid syndrome30.5CD40LG, F2
21celiac disease30.3GZMB
22hypothyroidism30.3PIK3C2A
23hypertension30.3F2
24lung cancer30.3SYP, CHGA
25cryoglobulinemia30.3CD40LG
26hepatitis e30.3CD40LG
27breast cancer30.3OXA1L, GZMB, RPS19
28prostate cancer30.3CHGA, OXA1L, GZMB
29disseminated intravascular coagulation30.3F2, PIK3C2A
30connective tissue disease30.3CD40LG, IL2RA, F2
31diamond-blackfan anemia 130.3RPL36, RPL35, RPL39, IL3, EPO, RPL35A
32thymoma11.0
33chronic lymphocytic leukemia10.8
34hemolytic anemia10.8
35acquired pure red cell aplasia10.8
36myasthenia gravis10.6
37transient erythroblastopenia of childhood10.6
38kidney disease10.5
39good syndrome10.5
40adult-onset still's disease10.5
41diffuse large b-cell lymphoma10.5
42acute leukemia10.5
43purpura10.5
44t-cell leukemia10.5
45enterocele10.4
46evans' syndrome10.4
47acquired thrombocytopenia10.4
48macroglobulinemia10.4
49autoimmune hepatitis10.4
50t-cell large granular lymphocyte leukemia10.4

Graphical network of the top 20 diseases related to Pure Red-Cell Aplasia:



Diseases related to pure red-cell aplasia

Clinical Features for Pure Red-Cell Aplasia

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Drugs & Therapeutics for Pure Red-Cell Aplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pure Red-Cell Aplasia

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Anatomical Context for Pure Red-Cell Aplasia

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32MalaCards
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MalaCards organs/tissues related to Pure Red-Cell Aplasia:

32
Bone, Bone marrow, T cells, B cells, Kidney, Myeloid, Liver, Thymus, Heart, Testes, Prostate, Skin, Breast, Thyroid, Pancreas, Lung, Brain, Endothelial

Animal Models for Pure Red-Cell Aplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pure Red-Cell Aplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3F2, IL3, IL2RA, HP, EPO, CD40LG

Publications for Pure Red-Cell Aplasia

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50PubMed
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Articles related to Pure Red-Cell Aplasia:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Risk of pure red cell aplasia in patients with hepatitis C receiving antiviral therapy and an erythropoiesis-stimulating agent. (24120841)
2014
2
Thymoma associated with hypogammaglobulinaemia and pure red cell aplasia. (24171048)
2013
3
Triple immunosuppressive therapy can accelerate the recovery of antibody-mediated pure red cell aplasia and allow successful concurrent resumption of erythropoietin. (22934452)
2012
4
Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. (21654161)
2011
5
Clinical use of cyclosporine as an adjunctive therapy in the management of feline idiopathic pure red cell aplasia. (21900029)
2011
6
Pure red cell aplasia associated with cytomegalovirus infection. (20445419)
2010
7
Improvement in erythropoieis-stimulating agent-induced pure red-cell aplasia by introduction of darbepoetin-I+ when the anti-erythropoietin antibody titer declines spontaneously. (21060762)
2010
8
Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation. (20432761)
2010
9
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. (17915315)
2008
10
Pure red-cell aplasia associated with pegylated interferon-alpha-2b plus ribavirin. (18615552)
2008
11
Valproate-induced pure red cell aplasia and megakaryocyte dysplasia. (18353161)
2008
12
Pure red cell aplasia associated with hemolytic anemia refractory to standard measures and resolved by rituximab in an elderly patient. (18807120)
2008
13
Epoetin-induced pure red cell aplasia: diagnosis and treatment. (18089975)
2007
14
Pure red cell aplasia associated with type I autoimmune polyglandular syndrome-successful response to treatment with mycophenolate mofetil: case report and review of literature. (17220208)
2007
15
Campath-1H induced pure red cell aplasia in a patient with chronic lymphatic leukaemia. (17005249)
2007
16
Pure red cell aplasia and thymoma. (17409794)
2007
17
A case of pure red cell aplasia complicated by Evans syndrome. (17694270)
2007
18
Primary SjAPgren syndrome complicated by autoimmune hemolytic anemia and pure red cell aplasia. (18091373)
2007
19
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
20
Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy. (16313965)
2006
21
Parvovirus B-19 induced acute pure red cell aplasia in patients with chronic lymphocytic leukemia and neurofibromatosis type-1. (17178664)
2006
22
Persistent pure red cell aplasia due to parvovirus B19 infection in a patient with Turner's syndrome. (16999728)
2006
23
Antibody-mediated pure red cell aplasia (PRCA): epidemiology, immunogenicity and risks. (15827058)
2005
24
Pure red cell aplasia with a clonal T-cell disorder. (15517267)
2005
25
Reduced intensity conditioning bone marrow transplantation for pure red cell aplasia: successful outcome but difficult post transplant course. (15895117)
2005
26
Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections. (16189165)
2005
27
Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia. (15252175)
2004
28
Pure red cell aplasia after ABO major-mismatched allogeneic peripheral blood stem cell transplantation successfully treated with plasma exchange and low-dose steroid: two case reports. (15124897)
2004
29
Drug-induced and antibody-mediated pure red cell aplasia: a review of literature and current knowledge. (15504708)
2004
30
Pure red-cell aplasia and epoetin therapy. (15459301)
2004
31
Pure red cell aplasia secondary to treatment with erythropoietin. (14696747)
2003
32
Pure red cell aplasia associated with expansion of CD3+ CD8+ granular lymphocytes expressing cytotoxicity against HLA-E+ cells. (14510958)
2003
33
Cryptogenic middle cerebral artery infarction in pure red cell aplasia. (17903942)
2003
34
Eprex (recombinant human erythropoietin alfa) and pure red cell aplasia--recommendations for administration to patients with CRF. (14677505)
2003
35
Pure red cell aplasia and lupus. (11836661)
2002
36
Pure red cell aplasia associated with small lymphocytic lymphoma. (11380388)
2001
37
Pure red cell aplasia associated with parvovirus B19 infection in T-large granular lymphocyte leukemia. (11911433)
2001
38
Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation. (10382963)
1999
39
Acquired pure red cell aplasia--a case report. (10874372)
1998
40
Parvovirus B19-associated transient pure red cell aplasia with lymphadenopathy: a case report. (9788269)
1998
41
Successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin. (9466287)
1997
42
Pure red cell aplasia caused by B19 parvovirus infection after autologous blood stem cell transplantation in a patient with chronic lymphocytic leukemia. (9001436)
1997
43
SjAPgren's syndrome and pure red cell aplasia. (8809454)
1996
44
Resolution of transfusion dependence by recombinant human erythropoietin (rHuEPO) in acquired pure red cell aplasia (PRCA) associated with myeloid metaplasia. (8435333)
1993
45
Acquired pure red cell aplasia: is chloroquine a culprit? (8307924)
1993
46
Rheumatoid arthritis with eosinophilic fasciitis and pure red cell aplasia. (2509696)
1989
47
Acquired pure red cell aplasia. (3103428)
1987
48
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
49
Acquired pure red-cell aplasia in adults. (4749529)
1973
50
Acquired pure red cell aplasia. (20791480)
1968

Genetic Variations for Pure Red-Cell Aplasia

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Expression for genes affiliated with Pure Red-Cell Aplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pure Red-Cell Aplasia

Search GEO for disease gene expression data for Pure Red-Cell Aplasia.

Pathways for genes affiliated with Pure Red-Cell Aplasia

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL3, IL2RA, EPO
2
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10.1RPS21, RPS17, RPS19
3
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10.1CD40LG, IL2RA, IL3
4
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9.9IL3, IL2RA, CD40LG, GZMB
5
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
6
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
7
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9.1RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
89.1RPL39, RPS19, RPS17, RPL27, RPL36, RPL35A
9
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9.0RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A

Compounds for genes affiliated with Pure Red-Cell Aplasia

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6CHGA, SYP
2ethanolamine oleate44 1111.5F2, HP
3glutamate4410.5CD40LG, PIK3C2A
4dexamethasone44 49 28 1113.5IL3, CD40LG, GZMB
5tuberculin4410.5CD40LG, HP, IL2RA
6aspartate4410.4F2, CD40LG, PIK3C2A
7ranitidine44 28 11 2413.4IL2RA, CD40LG, CHGA
8anaphylatoxin4410.4IL3, HP, RPS19
9mycophenolate mofetil44 49 1112.4IL3, IL2RA, EPO, CD40LG
10ribavirin44 49 1112.4CD40LG, EPO, HP, IL3
11carboplatin44 49 1112.4IL3, HP, EPO, CHGA
12theophylline44 28 11 2413.4IL2RA, EPO, CD40LG, CHGA
13eprex4410.3OXA1L, EPO
14glutaraldehyde4410.3CD40LG, OXA1L, SYP
15gp 1304410.3EPO, HP, IL2RA, IL3
16malondialdehyde4410.3PIK3C2A, EPO, HP, IL2RA
17sulfasalazine44 28 49 1113.3CD40LG, HP, IL2RA
18polyethylene glycol4410.3OXA1L, CD40LG, HP, F2
19neopterin4410.3GZMB, CD40LG, HP, IL2RA, IL3
20gold4410.2GZMB, PIK3C2A, SYP, CHGA
21pegfilgrastim44 1111.2IL3, EPO
22acetylcholine44 49 28 11 2414.2SYP, CHGA, CD40LG, IL2RA, IL3
23ionomycin4410.2SYP, CHGA, CD40LG, IL2RA, IL3
24etoposide44 49 59 1113.2GZMB, SYP, CHGA, IL2RA, IL3
25ivig4410.2GZMB, PIK3C2A, CD40LG, IL2RA, IL3
26heparin44 28 11 2413.2GZMB, PIK3C2A, CD40LG, HP, IL2RA
27vitamin d4410.2CHGA, EPO, HP, IL2RA, IL3
28hirudin4410.2PIK3C2A, CD40LG, F2
29citrate4410.2PIK3C2A, CHGA, HP, F2
30hyaluronic acid44 2411.2GZMB, CD40LG, HP, F2
31rapamycin4410.2IL3, IL2RA, EPO, CD40LG, GZMB
32formaldehyde44 2411.1IL2RA, CD40LG, CHGA, SYP
33aspirin44 49 28 2413.1OXA1L, CD40LG, HP, IL2RA, F2
34histamine44 28 2412.1SYP, CHGA, CD40LG, IL2RA, IL3
35thyroxine44 2411.1HP, CD40LG, OXA1L, PIK3C2A
36ascorbic acid44 2411.1PIK3C2A, CD40LG, EPO, HP, IL2RA, IL3
37epinephrine44 11 2412.0PIK3C2A, CHGA, CD40LG, HP, IL2RA, F2
38fibrinogen4410.0PIK3C2A, CHGA, OXA1L, CD40LG, HP, F2
39folate4410.0CD40LG, EPO, HP, IL2RA
40paraffin449.9IL2RA, CD40LG, CHGA, SYP, GZMB
41vegf449.9GZMB, PIK3C2A, SYP, CHGA, CD40LG, EPO
42cisplatin44 49 59 1112.9GZMB, PIK3C2A, SYP, CHGA, CD40LG, EPO
43lactate449.8GZMB, PIK3C2A, CHGA, CD40LG, EPO, HP
44cyclosporin a44 28 5911.8GZMB, PIK3C2A, CD40LG, EPO, HP, IL2RA
45testosterone44 59 11 2412.8PIK3C2A, SYP, CHGA, CD40LG, EPO, HP
46steroid449.8IL2RA, HP, CHGA, SYP, PIK3C2A, GZMB
47acth449.8HP, CHGA, SYP, PIK3C2A
48cysteine449.8GZMB, SYP, CHGA, OXA1L, CD40LG, HP
49calcitriol44 59 11 2412.7EPO, IL2RA, IL3, F2
50creatinine449.5F2, RPL27, PIK3C2A, SYP, CHGA, CD40LG

GO Terms for genes affiliated with Pure Red-Cell Aplasia

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16Gene Ontology
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Cellular components related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolic small ribosomal subunitGO:02262710.1RPS21, RPS17, RPS19
2ribosomeGO:0058409.6RPS19, RPS17, RPL27, RPL36A
3cytosolic large ribosomal subunitGO:0226259.5RPL35, RPL39, RPL36A, RPL35A, RPL36, RPL27
4cytosolGO:0058298.7RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A

Biological processes related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1rRNA processingGO:00636410.1RPL35A, RPS19, RPS17
2ribosomal small subunit biogenesisGO:04227410.1RPS17, RPS21, RPS19
3negative regulation of oxidoreductase activityGO:05135410.1HP, OXA1L
4ribosomal small subunit assemblyGO:00002810.0RPS19, RPS17
5viral life cycleGO:0190589.4RPL39, RPS21, RPL35, RPL36A, RPL35A, RPL36
6translational terminationGO:0064159.4RPL35A, RPL36A, RPL35, RPS21, RPL39, RPL36
7translational elongationGO:0064149.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
8SRP-dependent cotranslational protein targeting to membraneGO:0066149.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
9translational initiationGO:0064139.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
10viral transcriptionGO:0190839.4RPL35A, RPL36, RPL27, RPS19, RPL36A, RPL35
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001849.4RPS19, RPS17, RPL27, RPL36, RPL35A, RPL36A
12mRNA metabolic processGO:0160719.4RPS21, RPL35, RPL36A, RPL35A, RPL36, RPL27
13translationGO:0064129.3RPL35, RPL35A, RPS19, RPL36, RPL27, RPL36A
14RNA metabolic processGO:0160709.3RPS19, RPS17, RPL27, RPL36, RPL35A, RPS21
15viral processGO:0160329.3RPL35A, RPS17, RPS19, RPL36A, RPL35, RPS21
16gene expressionGO:0104679.2RPL27, RPS19, RPL35A, RPL36A, RPS17, RPL35
17cellular protein metabolic processGO:0442679.1RPL36, RPL36A, F2, RPL39, RPS21, RPS17

Molecular functions related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of ribosomeGO:0037359.1RPL39, RPS21, RPL35, RPL36A, RPL35A, RPL36

Products for genes affiliated with Pure Red-Cell Aplasia

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  • Antibodies
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Sources for Pure Red-Cell Aplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet