PRCA
MCID: PRR002
MIFTS: 54

Pure Red-Cell Aplasia (PRCA) malady

Rare diseases, Blood diseases categories

Summaries for Pure Red-Cell Aplasia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors... more...

MalaCards: Pure Red-Cell Aplasia, also known as pure red cell aplasia, is related to leukemia and hepatitis. An important gene associated with Pure Red-Cell Aplasia is EPO (erythropoietin), and among its related pathways are Paxillin-dependent events mediated by a4b1 and G protein signaling K RAS regulation pathway. The drug cyclophosphamide and the compounds erex and nesp have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells.

Aliases & Classifications for Pure Red-Cell Aplasia

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

pure red-cell aplasia 9 11 63
pure red cell aplasia 9 44
primary red cell aplasia 9
red-cell aplasia pure 46
red cell hypoplasia 9
prca 44


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Disease Ontology9 DOID:1340
MeSH36 D012010
NCIt41 C34974

Related Diseases for Pure Red-Cell Aplasia

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18GeneCards, 19GeneDecks
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Diseases related to Pure Red-Cell Aplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5HLA-A, HLA-DRB1, EPOR, EPO, IL2RA
2hepatitis31.3HLA-A, HLA-DRB1, ALB
3systemic lupus erythematosus31.3HLA-A, HLA-DRB1, IL2RA
4hepatitis c31.0HLA-A, HLA-DRB1, ALB
5graft versus host disease30.9HLA-A, HLA-DRB1, IL2RA
6arthritis30.8ALB, TIMP1, HLA-DRB1, HLA-A
7myelofibrosis30.7TIMP1, EPO
8rheumatoid arthritis30.7IL2RA, TIMP1, HLA-DRB1, HLA-A
9myeloma30.7EPOR, EPO, ALB
10thyroiditis30.5HLA-DRB1
11leprosy30.5HLA-DRB1
12lung cancer30.4SYP, CHGA, TIMP1
13breast cancer30.4TIMP1, EPOR, CHGA, SYP
14non-hodgkin lymphoma30.4IL2RA, HLA-DRB1, HLA-A
15diamond-blackfan anemia 130.4RPL23A, RPL35, RPL39, EPO
16connective tissue disease30.3HLA-A, HLA-DRB1, IL2RA, ALB
17tuberculosis30.3HLA-A, HLA-DRB1, IL2RA, ALB
18acquired pure red cell aplasia11.1
19thymoma11.0
20lupus erythematosus10.9
21chronic lymphocytic leukemia10.8
22hemolytic anemia10.8
23large granular lymphocyte leukemia10.8
24autoimmune hemolytic anemia10.8
25hematopoietic stem cell transplantation10.8
26myasthenia gravis10.7
27myelodysplastic syndromes10.7
28transient erythroblastopenia of childhood10.7
29hepatitis a10.6
30aplastic anemia10.6
31thrombocytopenia10.6
32kidney disease10.6
33b-cell lymphomas10.6
34diamond-blackfan anemia10.5
35good syndrome10.5
36diffuse large b-cell lymphoma10.5
37adult-onset still's disease10.5
38peritonitis10.5
39purpura10.5
40angioimmunoblastic t-cell lymphoma10.5
41chronic graft versus host disease10.5
42b-cell chronic lymphocytic leukemia10.5
43evans' syndrome10.4
44antiphospholipid syndrome10.4
45enterocele10.4
46macroglobulinemia10.4
47amyloidosis10.4
48hodgkin's lymphoma10.4
49myeloid leukemia10.4
50neutropenia10.4

Graphical network of the top 20 diseases related to Pure Red-Cell Aplasia:



Diseases related to pure red-cell aplasia

Symptoms for Pure Red-Cell Aplasia

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Drugs & Therapeutics for Pure Red-Cell Aplasia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pure Red-Cell Aplasia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pure Red-Cell Aplasia

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Anatomical Context for Pure Red-Cell Aplasia

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34MalaCards
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MalaCards organs/tissues related to Pure Red-Cell Aplasia:

34
Bone, Bone marrow, T cells, B cells, Kidney, Myeloid, Liver, Thymus, Heart, Pancreas, Endothelial, Breast, Thyroid, Skin, Testes, Lung, Brain, Prostate

Animal Models for Pure Red-Cell Aplasia or affiliated genes

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Publications for Pure Red-Cell Aplasia

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Sources:
53PubMed
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Articles related to Pure Red-Cell Aplasia:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Pure red cell aplasia complicating chronic lymphocytic leukemia: rapid response to high-dose methylprednisolone and rituximab. (23480495)
2013
2
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
3
Reversible pure red cell aplasia of pregnancy: a therapeutic challenge. (24431622)
2013
4
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
5
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
6
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
7
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
8
Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. (21654161)
2011
9
Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation. (18769919)
2009
10
Acquired pure red cell aplasia: updated review of treatment. (18510682)
2008
11
Spectrum of pure red cell aplasia in adult population of north-west India. (18616874)
2008
12
Epoetin-induced pure red cell aplasia: diagnosis and treatment. (18089975)
2007
13
Thirty-nine cases of pure red cell aplasia: a single center experience from India. (17558701)
2007
14
Treatment of resistant pure red cell aplasia after major ABO-incompatible bone marrow transplantation with human adipose tissue-derived mesenchymal stem cells. (17573692)
2007
15
Pure red cell aplasia in a patient of chronic granulocyte leukemia associated with imatinib. (17123082)
2007
16
Pure red cell aplasia with malignant thymoma: a rarity. (17183851)
2006
17
Epoetin-induced pure red cell aplasia successfully treated with androgens. (16736425)
2006
18
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
19
Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy. (16313965)
2006
20
Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia. (16111536)
2005
21
Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project. (16099877)
2005
22
Pure red cell aplasia and myelofibrosis in B-cell neoplasm. (16104450)
2005
23
Effect of tacrolimus in a patient with pure red-cell aplasia. (15686511)
2005
24
Clonal T cells of pure red-cell aplasia. (16044445)
2005
25
Antierythropoietin antibody-induced pure red cell aplasia: posttransplant evolution. (15138876)
2004
26
Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia. (15252175)
2004
27
Pure red cell aplasia following pegylated interferon alpha treatment. (15465516)
2004
28
Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion. (15522068)
2004
29
Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia. (15384028)
2004
30
Pure red cell aplasia in patients with refractory anaemia treated with two different recombinant erythropoietins. (15009075)
2004
31
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
32
A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. (12132531)
2002
33
Non-Hodgkin's lymphoma with pure red cell aplasia. (11868873)
2001
34
Th1/Th2 LYMPHOCYTE SUBSETS IN PURE RED CELL APLASIA (10233443)
1999
35
Tuberculosis pure red cell aplasia. (10206512)
1999
36
A patient with pure red cell aplasia and Good's syndrome. (10553168)
1999
37
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
38
Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity. (9609530)
1998
39
Association of pure red cell aplasia with T large granular lymphocyte leukaemia. (9930071)
1998
40
Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone. (8995089)
1997
41
Response to cyclosporin A and recombinant human erythropoietin in a case of B cell chronic lymphocytic leukemia and pure red cell aplasia. (8709652)
1996
42
Pure red cell aplasia: an unusual association with invasive thymoma. (10999075)
1996
43
Pure red-cell aplasia: a review. (8861276)
1996
44
IL-3 increases marrow and peripheral erythroid precursors in chronic pure red cell aplasia presenting in childhood. (7873394)
1995
45
Steroid-resistant acquired pure red cell aplasia: a partial remission induced by recombinant human erythropoietin. (1911372)
1991
46
Pure red cell aplasia in mixed connective tissue disease. (2509697)
1989
47
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
48
Remission of acquired pure red cell aplasia following plasma exchanges. (3918338)
1985
49
Electron microscopic demonstration of IgG antibodies directed to erythroblast in primary acquired pure red cell aplasia. (6448720)
1980
50
Therapeutic considerations in acquired pure red cell aplasia in adults. (6051100)
1967

Variations for Pure Red-Cell Aplasia

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Expression for genes affiliated with Pure Red-Cell Aplasia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pure Red-Cell Aplasia

Search GEO for disease gene expression data for Pure Red-Cell Aplasia.

Pathways for genes affiliated with Pure Red-Cell Aplasia

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN, 56Reactome
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Pathways related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b739
a4b1 and a4b7 Integrin signaling39
9.9EPOR, EPO
29.9EPO, EPOR
39.7IL2RA, HLA-DRB1
4
Show member pathways
Type III interferon signaling39
9.6IL2RA, EPO, EPOR
5
Show member pathways
9.3HLA-A, HLA-DRB1, EPOR
6
Show member pathways
9.3IL2RA, HLA-DRB1, HLA-A
7
Show member pathways
9.3IL2RA, HLA-DRB1, HLA-A
89.3IL2RA, HLA-DRB1, HLA-A
9
Show member pathways
9.3HLA-A, HLA-DRB1, IL2RA
10
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.3HLA-A, HLA-DRB1, IL2RA
11
Show member pathways
9.2IL2RA, EPO, EPOR, TIMP1
12
Show member pathways
9.2TIMP1, EPOR, EPO, IL2RA
139.1IL2RA, EPO, EPOR, HLA-DRB1
14
Show member pathways
9.0HLA-DRB1, TIMP1, EPOR, IL2RA
15
Show member pathways
8.5RPL39, RPL35, RPL23A
16
Show member pathways
Cytoplasmic Ribosomal Proteins39
8.5RPL39, RPL35, RPL23A

Compounds for genes affiliated with Pure Red-Cell Aplasia

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1erex4610.3EPOR, EPO
2nesp4610.3EPO, EPOR
3pp 1004610.2EPOR, EPO
4smcc4610.2CHGA, SYP
5pimonidazole4610.2EPOR, EPO
6111in-pentetreotide4610.1CHGA, SYP
7eprex4610.1EPO, ALB
8uva 14610.1TIMP1, IL2RA
9midodrine46 1211.0EPO, ALB
10s 1004610.0SYP, CHGA
11dr-104610.0HLA-A, HLA-DRB1
12tween 804610.0EPO, ALB
13methylcellulose469.9TIMP1, EPOR, EPO
14indoxyl sulfate469.9TIMP1, ALB
15theophylline46 30 25 1212.9IL2RA, CHGA, EPO
16bismuth46 2510.9IL2RA, ALB
17streptozotocin469.9SYP, CHGA, TIMP1
18bleomycin46 1210.8TIMP1, EPO, IL2RA
19polysulfone469.8ALB, IL2RA, EPO
20pixy321469.7EPO, TIMP1
21mycophenolate mofetil46 52 1211.7ALB, IL2RA, EPO
22azathioprine46 3 52 1212.7IL2RA, EPO, TIMP1
23vitamin b12469.7ALB, EPO, TIMP1
24gp 130469.6IL2RA, EPO, EPOR, TIMP1
25lenalidomide46 1210.6EPO, EPOR
26etoposide46 52 62 1212.5SYP, IL2RA, CHGA, TIMP1
27phorbol469.5TIMP1, CHGA, IL2RA
28norepinephrine46 25 1211.5TIMP1, CHGA, IL2RA, SYP
29p002469.5HLA-A, TIMP1, CHGA
30alpha tocopherol469.5TIMP1, IL2RA, ALB
31nifedipine46 30 52 1212.4IL2RA, CHGA, TIMP1
32folate469.4TIMP1, EPO, IL2RA, ALB
33calcitriol46 62 25 1212.4ALB, IL2RA, EPO, TIMP1
34paraffin469.3TIMP1, EPOR, CHGA, IL2RA, SYP
35cyclosporin a46 30 6211.3IL2RA, EPO, TIMP1, HLA-A
36creatinine469.1EPO, CHGA, IL2RA, SYP, ALB
37testosterone46 62 25 1212.1EPO, CHGA, IL2RA, SYP, ALB
38vitamin d469.1TIMP1, EPO, CHGA, IL2RA, ALB
39histamine46 30 2511.1TIMP1, CHGA, IL2RA, SYP, ALB
40cisplatin46 52 62 1212.0TIMP1, EPOR, EPO, CHGA, IL2RA, SYP
41vegf469.0TIMP1, EPOR, EPO, CHGA, IL2RA, SYP
42estrogen469.0TIMP1, EPOR, CHGA, IL2RA, SYP
43tacrolimus46 52 1211.0ALB, IL2RA, EPOR, TIMP1, HLA-A
44lactate469.0TIMP1, EPO, CHGA, ALB
45methotrexate52 46 1211.0HLA-DRB1, TIMP1, EPO, IL2RA, ALB
46glutamate468.8HLA-DRB1, TIMP1, EPOR, CHGA, IL2RA, SYP
47alanine468.8ALB, EPOR, TIMP1, HLA-DRB1, HLA-A
48cysteine468.7TIMP1, EPOR, CHGA, IL2RA, SYP, ALB
49arginine468.7HLA-A, HLA-DRB1, TIMP1, EPOR, CHGA, IL2RA
50tyrosine468.2HLA-A, HLA-DRB1, TIMP1, EPOR, EPO, CHGA

GO Terms for genes affiliated with Pure Red-Cell Aplasia

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17Gene Ontology
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Cellular components related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-A
2transport vesicle membraneGO:0306589.6CHGA, HLA-DRB1
3platelet alpha granule lumenGO:0310939.6ALB, TIMP1
4ER to Golgi transport vesicle membraneGO:0125079.3HLA-DRB1, HLA-A
5extracellular regionGO:0055768.7TIMP1, EPOR, EPO, CHGA, ALB
6cytosolic large ribosomal subunitGO:0226258.6RPL23A, RPL35, RPL39

Biological processes related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte maturationGO:04324910.0TIMP1, EPO
2inflammatory response to antigenic stimulusGO:0024379.8IL2RA, HLA-DRB1
3detection of bacteriumGO:0160459.7HLA-DRB1, HLA-A
4negative regulation of T cell proliferationGO:0421309.6IL2RA, HLA-DRB1
5viral transcriptionGO:0190838.8RPL23A, RPL35, RPL39
6translational terminationGO:0064158.8RPL39, RPL35, RPL23A
7translational elongationGO:0064148.8RPL23A, RPL35, RPL39
8SRP-dependent cotranslational protein targeting to membraneGO:0066148.8RPL39, RPL35, RPL23A
9viral life cycleGO:0190588.7RPL23A, RPL35, RPL39
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001848.7RPL39, RPL35, RPL23A
11translational initiationGO:0064138.7RPL23A, RPL35, RPL39
12mRNA metabolic processGO:0160718.5RPL39, RPL35, RPL23A
13translationGO:0064128.5RPL23A, RPL35, RPL39
14RNA metabolic processGO:0160708.2RPL23A, RPL35, RPL39
15viral processGO:0160328.2HLA-A, RPL39, RPL35, RPL23A

Molecular functions related to Pure Red-Cell Aplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-A
2structural constituent of ribosomeGO:0037358.2RPL23A, RPL35, RPL39

Products for genes affiliated with Pure Red-Cell Aplasia

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  • Antibodies
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Sources for Pure Red-Cell Aplasia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet