MCID: PRP030
MIFTS: 64

Purpura malady

Blood diseases category

Summaries for Purpura

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66Wikipedia, 34MalaCards
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Wikipedia:66 Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on... more...

MalaCards: Purpura, also known as purpuric disorder, is related to purpura fulminans and autoimmune thrombocytopenic purpura. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Signal transduction by L1 and Ephrin B reverse signaling. The drugs epoprostenol and epoprostenol sodium and the compounds nadroparin and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Purpura

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

purpura 9 46 63
purpuric disorder 9
purpura nos 9


External Ids:

Disease Ontology9 DOID:3326
MeSH36 D011693
NCIt41 C78787

Related Diseases for Purpura

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18GeneCards, 19GeneDecks
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Diseases related to Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 589)
idRelated DiseaseScoreTop Affiliating Genes
1purpura fulminans31.6SERPINC1, PROC, PROCR
2autoimmune thrombocytopenic purpura31.4ITGB3, IFNA2, THPO, MPL, SELP
3hemolytic-uremic syndrome31.0ADAMTS13, THBD, VWF
4thrombotic thrombocytopenic purpura, acquired30.9ADAMTS13
5lupus erythematosus30.9IFNA2, APOH
6hepatitis30.8THPO, IFNA2, SELP
7sepsis30.6PROC, SELP, ADAMTS13, SERPINC1, THBD, PROCR
8protein s deficiency30.6F3, SERPINC1, APOH
9protein c deficiency30.6PROC, SERPINC1, APOH, THBD, PROCR
10vasculitis30.6THBD, SELP, VWF, APOH, CD79A, IFNA2
11chickenpox30.5CD79A
12meningococcemia30.5SERPINC1, THBD, PROCR
13disseminated intravascular coagulation30.5THPO, PROC, THBD, F3, SERPINC1, ADAMTS13
14hemolytic anemia30.5VWF, APOH, ADAMTS13, IFNA2, F3
15polyarteritis nodosa30.4IFNA2
16leukemia30.4ITGB3, ITGA2B, MPL, THPO, CD79A, IFNA2
17systemic lupus erythematosus30.4FCGR2C, VWF, THBD, APOH, MPL, ADAMTS13
18septic shock30.4THBD, SERPINC1, F3
19thrombocytopenia30.3MPL, SERPINC1, SELP, ADAMTS13, F3, IFNA2
20cryoglobulinemia30.3CD79A, IFNA2, APOH
21mumps30.3CD79A
22connective tissue disease30.2VWF, THBD, APOH, F3, CD79A
23portal vein thrombosis30.2THPO, SERPINC1
24membranoproliferative glomerulonephritis30.2IFNA2, CD79A
25central retinal vein occlusion30.1APOH
26ulcerative colitis30.1PROCR, CD79A, THPO, SELP
27hellp syndrome30.1VWF, APOH, SERPINC1, ADAMTS13
28retinal vein occlusion30.1APOH, SERPINC1
29rheumatoid arthritis30.1APOH, SELP, CD79A, THPO, ITGB3
30myocardial infarction30.1F3, VWF, PROCR, ADAMTS13, ITGB3, ITGA2B
31liver cirrhosis30.0THPO, SERPINC1, IFNA2, F3, ADAMTS13
32thrombocytopenia due to platelet alloimmunization30.0ITGA2B, THPO, MPL, SELP
33coronary thrombosis30.0SERPINC1, VWF, ITGB3, F3
34glanzmann's thrombasthenia30.0ITGB3, ITGA2B
35lupus nephritis30.0CD79A, ADAMTS13, APOH, THBD
36hemorrhagic disease30.0SERPINC1, F3, VWF, THBD
37hemarthrosis29.9F3, VWF
38factor vii deficiency29.9F3, SERPINC1
39antiphospholipid syndrome29.9F3, PROCR, ADAMTS13, CD79A, SELP, SERPINC1
40splenomegaly29.9IFNA2, MPL, THPO
41proteinuria29.9APOH, CD79A, ADAMTS13
42leukopenia29.9F3, IFNA2, CD79A
43sagittal sinus thrombosis29.8SERPINC1
44thrombophlebitis29.8APOH
45retinal artery occlusion29.8APOH
46factor xi deficiency29.8F3
47retinal vascular occlusion29.8APOH
48hypersplenism29.8THPO
49factor viii deficiency29.8F3
50proliferative glomerulonephritis29.8CD79A, SELP

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Symptoms for Purpura

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Drugs & Therapeutics for Purpura

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Purpura

Search CenterWatch for Purpura

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Purpura

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Anatomical Context for Purpura

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34MalaCards
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MalaCards organs/tissues related to Purpura:

34
Skin, T cells, Endothelial, Bone, Liver, Bone marrow, B cells, Kidney, Lung, Testes, Heart, Spleen, Prostate, Monocytes, Breast, Colon, Thyroid, Pituitary, Brain, Smooth muscle, Retina, Myeloid, Pancreatic islet, Appendix, Testis, Pancreas, Lymph node, Cortex

Animal Models for Purpura or affiliated genes

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38MGI
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Publications for Purpura

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53PubMed
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Articles related to Purpura:

(show top 50)    (show all 2323)
idTitleAuthorsYear
1
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
2
Thrombotic thrombocytopenic purpura in children. (23422353)
2013
3
Intravenous immunoglobulin in Henoch-SchAPnlein purpura complicated by cerebral hemorrhage. (22829413)
2013
4
Post-cardiac surgery thrombotic thrombocytopenic purpura with digital ischaemia. (23659403)
2013
5
Facial purpura associated with Capnocytophaga canimorsus septicaemia; role of sunlight? (23816547)
2013
6
Acquired thrombotic thrombocytopenic purpura (TTP) induced by silicone breast implants in 37-year old woman. (23477708)
2013
7
Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura. (23346910)
2013
8
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura. (24298390)
2013
9
Idiopathic thrombocytopenic purpura and hypokalaemic dRTA with compensated haemolysis and striking acanthocytosis in a band 3 (SLC4A1/AE1) A858D homozygote. (23053187)
2013
10
R1933X mutation in the MYH9 gene in May-Hegglin anomaly mimicking idiopathic thrombocytopenic purpura. (23759689)
2013
11
Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report. (24117464)
2013
12
Inverse correlation of free and immune complex-sequestered anti-ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura. (22044668)
2012
13
Management of Thrombotic Thrombocytopenic Purpura with Autoantibodies to ADAMTS-13 and Concurrent Preeclampsia in Pregnancy: Multidisciplinary Team Approach. (23946903)
2012
14
Thrombotic thrombocytopenic purpura triggered by influenza A virus subtype H1N1 infection. (22094185)
2012
15
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
16
Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement. (21143648)
2011
17
Superior mesenteric artery syndrome: risk factor for duodenal involvement in Henoch-SchAPnlein purpura. (21129122)
2011
18
Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura. (21535387)
2011
19
Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. (20652968)
2010
20
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
21
Postoperative thrombotic thrombocytopenic purpura after open heart operations. (20103218)
2010
22
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
23
Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies. (19190804)
2009
24
Thrombopoietin-receptor agonists: a revolution in the therapeutic strategies of immune thrombocytopenic purpura?]. (19019500)
2009
25
Henoch-ShAPnlein purpura]. (19345173)
2009
26
Idiopathic thrombocytopenic purpura with isolated tuberculous splenic abscess. (19224070)
2009
27
Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (19317746)
2009
28
Massive cerebrovascular infarct due to the catastrophic antiphospholipid syndrome in a patient with idiopathic thrombocytopenic purpura. (19617232)
2009
29
Plasma exchange therapy for thrombotic thrombocytopenic purpura in pediatric patients with liver transplantation. (18929799)
2008
30
HLA-DRB1 alleles and Henoch-SchAPnlein purpura: susceptibility and severity of disease. (18412308)
2008
31
Antioxidant enzyme activities, lipid peroxidation, and total antioxidant status in children with Henoch-SchAPnlein purpura. (17646900)
2008
32
Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis. (18339897)
2008
33
Unexpected superimposition of nutcracker effect in various conditions: is it an unrecognized confounding factor? Comment on: Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl. (Eur J Pediatr. 2006 Sep 29; [Epub ahead of print]). (17180389)
2007
34
Cyclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activity. (17910638)
2007
35
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
36
Thrombotic thrombocytopenic purpura. (16102032)
2005
37
Clinical features and laboratory findings of thrombotic thrombocytopenic purpura associated with ticlopidine]. (16104532)
2005
38
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
39
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
40
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
41
Subacute painful quadriplegia and purpura. (14678939)
2003
42
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. (12877681)
2003
43
An update on the pathogenesis and management of acquired thrombotic thrombocytopenic purpura. (12858075)
2003
44
Henoch-SchAPnlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations. (12022354)
2002
45
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
46
Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenic purpura. (10755821)
2000
47
Henoch-SchAPnlein purpura with immunoglobulin A nephropathy and abnormalities of immunoglobulin A in a Wiskott-Aldrich syndrome carrier. (9016903)
1997
48
Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. (1791222)
1991
49
Successful treatment of neonatal purpura fulminans with epoprostenol. (1744852)
1991
50
Henoch-schoenlein purpura with colonic involvement. A case report. (6450111)
1980

Variations for Purpura

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Expression for genes affiliated with Purpura

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for genes affiliated with Purpura

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 52PharmGKB, 55R&D Systems
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Pathways related to Purpura according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ITGA2B, ITGB3
29.8ITGA2B, ITGB3
3
Show member pathways
9.6THPO, ITGB3, ITGA2B
49.6THPO, ITGB3, ITGA2B
59.5VWF, ITGB3, ITGA2B
6
Show member pathways
9.2ITGA2B, ITGB3, SELP, VWF
7
Show member pathways
9.1THBD, SELP, PROC, ITGB3
89.0ITGA2B, ITGB3, IFNA2, VWF
9
Show member pathways
8.9VWF, THPO, MPL, ITGB3, ITGA2B
10
Show member pathways
8.9F3, PROC, SERPINC1, THBD
11
Show member pathways
8.8ITGA2B, ITGB3, IFNA2, MPL, THPO
12
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.5VWF, THBD, SERPINC1, PROC, F3
13
Show member pathways
8.5VWF, THBD, SERPINC1, PROC, F3
14
Show member pathways
6.5ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Compounds for genes affiliated with Purpura

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1nadroparin46 1210.5SERPINC1, SELP, F3
2sarpogrelate hydrochloride469.5SELP, THBD, SERPINC1
3hydroxyethyl starch469.4SERPINC1, VWF, SELP, F3
4ppack469.4VWF, SELP, F3, SERPINC1
5clopidogrel46 52 25 1212.2SELP, VWF, ITGB3, SERPINC1, F3
6bivalirudin46 1210.2THBD, SERPINC1, SELP, F3
7argatroban46 1210.2THBD, SELP, F3, SERPINC1
811-dehydrothromboxane b2469.1SELP, APOH, THBD, VWF
9dipyridamole46 62 30 1212.1VWF, F3, CD79A, SELP
10ristocetin469.1ITGB3, F3, ADAMTS13, SELP, SERPINC1, VWF
11iloprost62 30 46 1212.0SELP, THPO, F3, THBD, SERPINC1
12ptca468.9THBD, SELP, F3, APOH
13tirofiban46 129.9ITGA2B, ITGB3, F3, SELP, SERPINC1, VWF
14ticlopidine46 129.9SELP, F3, VWF, SERPINC1, APOH, ADAMTS13
15dermatan sulfate468.8SELP, SERPINC1, THBD, VWF, F3
16aprotinin46 129.7THBD, SELP, SERPINC1, VWF, F3
17cardiolipin46 129.7APOH, F3, CD79A, THBD
18txb2468.7VWF, THBD, SELP, F3, APOH
19desmopressin46 62 30 1211.7SERPINC1, SELP, THBD, VWF, F3, ADAMTS13
20thromboxane46 259.7VWF, SELP, MPL, THBD, THPO, APOH
21gamma-carboxyglutamic acid468.6THBD, F3, PROC, PROCR
22polyethylene glycol468.6IFNA2, SERPINC1, MPL, THPO, THBD, CD79A
23betacarotene468.6IFNA2, APOH, THBD, VWF, CD79A
24epinephrine46 25 1210.6SELP, F3, VWF, CD79A, THPO, IFNA2
25rituximab46 52 1210.6ADAMTS13, FCGR2C, APOH, CD79A, IFNA2, VWF
26citrate468.6CD79A, VWF, THBD, SERPINC1, SELP, F3
27polysaccharide468.5F3, SERPINC1, THPO, THBD, SELP, CD79A
28prednisolone46 30 1210.5THBD, APOH, VWF, CD79A, IFNA2
29kininogen468.5APOH, SERPINC1, SELP, THBD, F3, VWF
30homocysteine46 259.4SERPINC1, SELP, F3, THBD, VWF, APOH
31abciximab46 129.4ITGA2B, ITGB3, F3, SELP, SERPINC1, FCGR2C
32histamine46 30 2510.3IFNA2, THBD, VWF, THPO, CD79A, SELP
33agarose468.2APOH, VWF, THBD, THPO, IFNA2
34prostacyclin468.2SERPINC1, F3, SELP, APOH, VWF, THPO
35phosphatidylserine46 30 1210.2F3, THBD, VWF, APOH, SELP, ITGB3
36cyclophosphamide46 52 1210.2F3, IFNA2, APOH, THBD, ADAMTS13, VWF
37warfarin46 52 25 1211.0CD79A, F3, PROC, SELP, SERPINC1, APOH
38hirudin467.9THBD, THPO, VWF, SERPINC1, SELP, PROCR
39creatinine467.8SERPINC1, SELP, APOH, THPO, ADAMTS13, F3
40phospholipid467.7THBD, APOH, VWF, PROC, F3, PROCR
41steroid467.6CD79A, THPO, THBD, ITGB3, IFNA2, ADAMTS13
42estrogen467.6VWF, THPO, THBD, APOH, SERPINC1, ITGB3
43alanine467.5MPL, VWF, THPO, CD79A, SERPINC1, F3
44heparin46 30 25 1210.5ADAMTS13, F3, PROC, SELP, THPO, SERPINC1
45adp46 30 259.5ITGB3, SERPINC1, MPL, THBD, ITGA2B, VWF
46aspirin46 52 30 2510.4ITGB3, F3, SELP, SERPINC1, MPL, APOH
47cysteine467.2MPL, F3, CD79A, ITGA2B, ITGB3, IFNA2
48serine466.8PROC, PROCR, ADAMTS13, F3, ITGB3, ITGA2B
49fibrinogen466.1VWF, THPO, THBD, APOH, SELP, ADAMTS13
50vegf466.1SERPINC1, SELP, PROCR, F3, IFNA2, ITGB3

GO Terms for genes affiliated with Purpura

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17Gene Ontology
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Cellular components related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:0083059.8ITGA2B, ITGB3
2platelet alpha granule membraneGO:0310929.7SELP, ITGB3, ITGA2B
3external side of plasma membraneGO:0098979.3VWF, SELP, ITGA2B, CD79A
4extracellular matrixGO:0310129.0F3, APOH, VWF
5cell surfaceGO:0099868.7THBD, APOH, ADAMTS13, F3
6integral component of plasma membraneGO:0058877.8THBD, MPL, SELP, PROCR, ITGB3, ITGA2B
7extracellular spaceGO:0056157.6IFNA2, F3, ADAMTS13, SELP, SERPINC1, APOH
8plasma membraneGO:0058867.0THBD, MPL, FCGR2C, SERPINC1, SELP, PROC

Biological processes related to Purpura according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1platelet aggregationGO:0705279.8ITGA2B, ITGB3
2positive regulation of leukocyte migrationGO:0026879.8ITGA2B, SELP
3integrin-mediated signaling pathwayGO:0072299.8ADAMTS13, ITGB3, ITGA2B
4cell-matrix adhesionGO:0071609.7ITGA2B, ITGB3, ADAMTS13
5negative regulation of fibrinolysisGO:0519189.5THBD, APOH
6negative regulation of blood coagulationGO:0301959.4PROC, APOH, THBD
7blood coagulation, intrinsic pathwayGO:0075979.4APOH, VWF
8platelet degranulationGO:0025769.4VWF, SELP, ITGB3, ITGA2B
9leukocyte migrationGO:0509009.2ITGB3, PROC, SELP, THBD
10cell adhesionGO:0071559.1VWF, SELP, ITGB3, ITGA2B
11platelet activationGO:0301688.7VWF, THPO, MPL, SELP, ADAMTS13, ITGB3
12blood coagulationGO:0075966.0ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Molecular functions related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.4SELP, APOH, VWF
2protease bindingGO:0020209.3VWF, SERPINC1, F3
3heparin bindingGO:0082019.2SELP, SERPINC1, APOH
4identical protein bindingGO:0428029.1ITGA2B, ITGB3, APOH, VWF
5transmembrane signaling receptor activityGO:0048888.8THBD, MPL, FCGR2C, CD79A
6protein bindingGO:0055155.2ITGA2B, VWF, THBD, APOH, FCGR2C, SERPINC1

Products for genes affiliated with Purpura

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Purpura

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet