MCID: PRP030
MIFTS: 65

Purpura malady

Blood diseases category

Summaries for Purpura

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Wikipedia:64 Purpura (from Latin: purpura, meaning \"purple\") are red or purple discolorations on the skin that do... more...

MalaCards based summary: Purpura, also known as purpuric disorder, is related to thrombotic thrombocytopenic purpura, acquired and autoimmune thrombocytopenic purpura. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Signal transduction by L1 and Ephrin B reverse signaling. The drugs epoprostenol and epoprostenol sodium and the compounds nadroparin and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Purpura

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Sources:
9Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Purpura, Aliases & Descriptions:

Name: Purpura 9 44 61
Purpuric Disorder 9 61
 
Purpura Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:3326
MeSH34 D011693
NCIt39 C78787

Related Diseases for Purpura

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Diseases related to Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 603)
idRelated DiseaseScoreTop Affiliating Genes
1thrombotic thrombocytopenic purpura, acquired31.6ADAMTS13
2autoimmune thrombocytopenic purpura31.4THPO, MPL, SELP, IFNA2, ITGB3
3lupus erythematosus31.2APOH, IFNA2
4hemolytic-uremic syndrome31.2VWF, THBD, ADAMTS13
5chickenpox31.1CD79A
6hepatitis31.1THPO, SELP, IFNA2
7central retinal vein occlusion30.8APOH
8mumps30.8CD79A
9protein s deficiency30.8APOH, SERPINC1, F3
10polyarteritis nodosa30.8IFNA2
11portal vein thrombosis30.7THPO, SERPINC1
12retinal vein occlusion30.6APOH, SERPINC1
13cryoglobulinemia30.5APOH, IFNA2, CD79A
14membranoproliferative glomerulonephritis30.5CD79A, IFNA2
15septic shock30.5THBD, SERPINC1, F3
16bleeding disorder, platelet-type, 16, autosomal dominant30.5ITGB3, ITGA2B
17glanzmann's thrombasthenia30.5ITGB3, ITGA2B
18meningococcemia30.5PROCR, SERPINC1, THBD
19sagittal sinus thrombosis30.4SERPINC1
20thrombophlebitis30.4APOH
21retinal artery occlusion30.4APOH
22factor xi deficiency30.4F3
23hemolytic anemia30.4VWF, APOH, ADAMTS13, F3, IFNA2
24retinal vascular occlusion30.4APOH
25disseminated intravascular coagulation30.3THPO, THBD, SERPINC1, ADAMTS13, PROC, F3
26hemarthrosis30.3VWF, F3
27hellp syndrome30.3VWF, APOH, SERPINC1, ADAMTS13
28hypersplenism30.3THPO
29congenital amegakaryocytic thrombocytopenia30.3THPO, MPL
30factor viii deficiency30.2F3
31factor vii deficiency30.2SERPINC1, F3
32leukemia30.2THPO, MPL, IFNA2, ITGB3, ITGA2B, CD79A
33proliferative glomerulonephritis30.2SELP, CD79A
34protein c deficiency30.2PROC, SERPINC1, APOH, THBD, PROCR
35prothrombin deficiency30.2APOH, SERPINC1
36dysfibrinogenemia30.2THBD, SERPINC1
37vasculitis30.2VWF, THBD, APOH, SELP, IFNA2, CD79A
38splenomegaly30.2THPO, MPL, IFNA2
39coronary thrombosis30.2VWF, SERPINC1, F3, ITGB3
40polycythemia30.1THPO, MPL, ITGB3
41rheumatoid arthritis30.1CD79A, ITGB3, SELP, APOH, THPO
42syphilis30.1APOH, CD79A
43severe pre-eclampsia30.1APOH, SERPINC1
44ulcerative colitis30.1THPO, SELP, PROCR, CD79A
45proteinuria30.1CD79A, ADAMTS13, APOH
46eclampsia30.1SERPINC1, THBD
47connective tissue disease30.1VWF, THBD, APOH, F3, CD79A
48leukopenia30.0CD79A, IFNA2, F3
49lupus nephritis30.0CD79A, ADAMTS13, APOH, THBD
50galactosemia30.0THPO, SERPINC1, F3

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Symptoms for Purpura

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Drugs & Therapeutics for Purpura

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Drug clinical trials:

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Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Purpura

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Anatomical Context for Purpura

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MalaCards organs/tissues related to Purpura:

32
Skin, T cells, Bone, Endothelial, Bone marrow, Liver, B cells, Kidney, Lung, Testes, Heart, Spleen, Colon, Neutrophil, Prostate, Monocytes, Thyroid, Breast, Pituitary, Brain, Retina, Smooth muscle, Lymph node, Cortex, Pancreas, Testis, Myeloid, Appendix, Pancreatic islet

Animal Models for Purpura or affiliated genes

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Publications for Purpura

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Articles related to Purpura:

(show top 50)    (show all 2381)
idTitleAuthorsYear
1
Fetal intracranial hemorrhage related to maternal autoimmune thrombocytopenic purpura. (24952237)
2014
2
Acute and fatal thrombocytopenic thrombotic purpura after a single dose of pemetrexed. (25370901)
2014
3
Ludwig's angina after severe thrombocytopenic purpura associated with dengue fever. (24603747)
2014
4
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
5
Thrombotic thrombocytopenic purpura in children. (23422353)
2013
6
Intravenous immunoglobulin in Henoch-SchAPnlein purpura complicated by cerebral hemorrhage. (22829413)
2013
7
Post-cardiac surgery thrombotic thrombocytopenic purpura with digital ischaemia. (23659403)
2013
8
Facial purpura associated with Capnocytophaga canimorsus septicaemia; role of sunlight? (23816547)
2013
9
Acquired thrombotic thrombocytopenic purpura (TTP) induced by silicone breast implants in 37-year old woman. (23477708)
2013
10
Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura. (23346910)
2013
11
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura. (24298390)
2013
12
Idiopathic thrombocytopenic purpura and hypokalaemic dRTA with compensated haemolysis and striking acanthocytosis in a band 3 (SLC4A1/AE1) A858D homozygote. (23053187)
2013
13
R1933X mutation in the MYH9 gene in May-Hegglin anomaly mimicking idiopathic thrombocytopenic purpura. (23759689)
2013
14
Inverse correlation of free and immune complex-sequestered anti-ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura. (22044668)
2012
15
Management of Thrombotic Thrombocytopenic Purpura with Autoantibodies to ADAMTS-13 and Concurrent Preeclampsia in Pregnancy: Multidisciplinary Team Approach. (23946903)
2012
16
Thrombotic thrombocytopenic purpura triggered by influenza A virus subtype H1N1 infection. (22094185)
2012
17
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
18
Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement. (21143648)
2011
19
Superior mesenteric artery syndrome: risk factor for duodenal involvement in Henoch-SchAPnlein purpura. (21129122)
2011
20
Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura. (21535387)
2011
21
Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. (20652968)
2010
22
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
23
Postoperative thrombotic thrombocytopenic purpura after open heart operations. (20103218)
2010
24
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
25
Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies. (19190804)
2009
26
Thrombopoietin-receptor agonists: a revolution in the therapeutic strategies of immune thrombocytopenic purpura?]. (19019500)
2009
27
Henoch-ShAPnlein purpura]. (19345173)
2009
28
Idiopathic thrombocytopenic purpura with isolated tuberculous splenic abscess. (19224070)
2009
29
Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (19317746)
2009
30
Plasma exchange therapy for thrombotic thrombocytopenic purpura in pediatric patients with liver transplantation. (18929799)
2008
31
HLA-DRB1 alleles and Henoch-SchAPnlein purpura: susceptibility and severity of disease. (18412308)
2008
32
Antioxidant enzyme activities, lipid peroxidation, and total antioxidant status in children with Henoch-SchAPnlein purpura. (17646900)
2008
33
Unexpected superimposition of nutcracker effect in various conditions: is it an unrecognized confounding factor? Comment on: Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl. (Eur J Pediatr. 2006 Sep 29; [Epub ahead of print]). (17180389)
2007
34
Cyclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activity. (17910638)
2007
35
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
36
Thrombotic thrombocytopenic purpura. (16102032)
2005
37
Clinical features and laboratory findings of thrombotic thrombocytopenic purpura associated with ticlopidine]. (16104532)
2005
38
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
39
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
40
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
41
Subacute painful quadriplegia and purpura. (14678939)
2003
42
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. (12877681)
2003
43
An update on the pathogenesis and management of acquired thrombotic thrombocytopenic purpura. (12858075)
2003
44
Henoch-SchAPnlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations. (12022354)
2002
45
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
46
Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenic purpura. (10755821)
2000
47
Henoch-SchAPnlein purpura with immunoglobulin A nephropathy and abnormalities of immunoglobulin A in a Wiskott-Aldrich syndrome carrier. (9016903)
1997
48
Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. (1791222)
1991
49
Successful treatment of neonatal purpura fulminans with epoprostenol. (1744852)
1991
50
Henoch-schoenlein purpura with colonic involvement. A case report. (6450111)
1980

Variations for Purpura

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Expression for genes affiliated with Purpura

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Expression patterns in normal tissues for genes affiliated with Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for genes affiliated with Purpura

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Pathways related to Purpura according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ITGA2B, ITGB3
29.8ITGA2B, ITGB3
3
Show member pathways
9.6THPO, ITGB3, ITGA2B
49.6THPO, ITGB3, ITGA2B
59.5VWF, ITGB3, ITGA2B
6
Show member pathways
9.2ITGA2B, ITGB3, SELP, VWF
7
Show member pathways
9.1THBD, SELP, PROC, ITGB3
89.0ITGA2B, ITGB3, IFNA2, VWF
9
Show member pathways
8.9VWF, THPO, MPL, ITGB3, ITGA2B
10
Show member pathways
8.9F3, PROC, SERPINC1, THBD
11
Show member pathways
8.8ITGA2B, ITGB3, IFNA2, MPL, THPO
12
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.5VWF, THBD, SERPINC1, PROC, F3
13
Show member pathways
8.5VWF, THBD, SERPINC1, PROC, F3
14
Show member pathways
6.5ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Compounds for genes affiliated with Purpura

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Compounds related to Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1nadroparin44 1210.5SERPINC1, SELP, F3
2sarpogrelate hydrochloride449.5SELP, THBD, SERPINC1
3hydroxyethyl starch449.4SERPINC1, VWF, SELP, F3
4ppack449.4VWF, SELP, F3, SERPINC1
5clopidogrel44 50 25 1212.2SELP, VWF, ITGB3, SERPINC1, F3
6bivalirudin44 1210.2THBD, SERPINC1, SELP, F3
7argatroban44 1210.2THBD, SELP, F3, SERPINC1
811-dehydrothromboxane b2449.1SELP, APOH, THBD, VWF
9dipyridamole44 60 29 1212.1VWF, F3, CD79A, SELP
10ristocetin449.1ITGB3, F3, ADAMTS13, SELP, SERPINC1, VWF
11iloprost60 29 44 1212.0SELP, THPO, F3, THBD, SERPINC1
12ptca448.9THBD, SELP, F3, APOH
13tirofiban44 129.9ITGA2B, ITGB3, F3, SELP, SERPINC1, VWF
14ticlopidine44 129.9SELP, F3, VWF, SERPINC1, APOH, ADAMTS13
15dermatan sulfate448.8SELP, SERPINC1, THBD, VWF, F3
16aprotinin44 129.7THBD, SELP, SERPINC1, VWF, F3
17cardiolipin44 129.7APOH, F3, CD79A, THBD
18txb2448.7VWF, THBD, SELP, F3, APOH
19desmopressin44 60 29 1211.7SERPINC1, SELP, THBD, VWF, F3, ADAMTS13
20thromboxane44 259.7VWF, SELP, MPL, THBD, THPO, APOH
21gamma-carboxyglutamic acid448.6THBD, F3, PROC, PROCR
22polyethylene glycol448.6IFNA2, SERPINC1, MPL, THPO, THBD, CD79A
23betacarotene448.6IFNA2, APOH, THBD, VWF, CD79A
24epinephrine44 25 1210.6SELP, F3, VWF, CD79A, THPO, IFNA2
25rituximab44 50 1210.6ADAMTS13, FCGR2C, APOH, CD79A, IFNA2, VWF
26citrate448.6CD79A, VWF, THBD, SERPINC1, SELP, F3
27polysaccharide448.5F3, SERPINC1, THPO, THBD, SELP, CD79A
28prednisolone44 29 1210.5THBD, APOH, VWF, CD79A, IFNA2
29kininogen448.5APOH, SERPINC1, SELP, THBD, F3, VWF
30homocysteine44 259.4SERPINC1, SELP, F3, THBD, VWF, APOH
31abciximab44 129.4ITGA2B, ITGB3, F3, SELP, SERPINC1, FCGR2C
32histamine44 29 2510.3IFNA2, THBD, VWF, THPO, CD79A, SELP
33agarose448.2APOH, VWF, THBD, THPO, IFNA2
34prostacyclin448.2SERPINC1, F3, SELP, APOH, VWF, THPO
35phosphatidylserine44 29 1210.2F3, THBD, VWF, APOH, SELP, ITGB3
36cyclophosphamide44 50 1210.2F3, IFNA2, APOH, THBD, ADAMTS13, VWF
37warfarin44 50 25 1211.0CD79A, F3, PROC, SELP, SERPINC1, APOH
38hirudin447.9THBD, THPO, VWF, SERPINC1, SELP, PROCR
39creatinine447.8SERPINC1, SELP, APOH, THPO, ADAMTS13, F3
40phospholipid447.7THBD, APOH, VWF, PROC, F3, PROCR
41steroid447.6CD79A, THPO, THBD, ITGB3, IFNA2, ADAMTS13
42estrogen447.6VWF, THPO, THBD, APOH, SERPINC1, ITGB3
43alanine447.5MPL, VWF, THPO, CD79A, SERPINC1, F3
44heparin44 29 25 1210.5ADAMTS13, F3, PROC, SELP, THPO, SERPINC1
45adp44 29 259.5ITGB3, SERPINC1, MPL, THBD, ITGA2B, VWF
46aspirin44 50 29 2510.4ITGB3, F3, SELP, SERPINC1, MPL, APOH
47cysteine447.2MPL, F3, CD79A, ITGA2B, ITGB3, IFNA2
48serine446.8PROC, PROCR, ADAMTS13, F3, ITGB3, ITGA2B
49fibrinogen446.1VWF, THPO, THBD, APOH, SELP, ADAMTS13
50vegf446.1SERPINC1, SELP, PROCR, F3, IFNA2, ITGB3

GO Terms for genes affiliated with Purpura

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Cellular components related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:0083059.8ITGA2B, ITGB3
2platelet alpha granule membraneGO:0310929.7SELP, ITGB3, ITGA2B
3external side of plasma membraneGO:0098979.3VWF, SELP, ITGA2B, CD79A
4extracellular matrixGO:0310129.0F3, APOH, VWF
5cell surfaceGO:0099868.7THBD, APOH, ADAMTS13, F3
6integral component of plasma membraneGO:0058877.8THBD, MPL, SELP, PROCR, ITGB3, ITGA2B
7extracellular spaceGO:0056157.6IFNA2, F3, ADAMTS13, SELP, SERPINC1, APOH
8plasma membraneGO:0058867.0THBD, MPL, FCGR2C, SERPINC1, SELP, PROC

Biological processes related to Purpura according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1platelet aggregationGO:0705279.8ITGA2B, ITGB3
2positive regulation of leukocyte migrationGO:0026879.8ITGA2B, SELP
3integrin-mediated signaling pathwayGO:0072299.8ADAMTS13, ITGB3, ITGA2B
4cell-matrix adhesionGO:0071609.7ITGA2B, ITGB3, ADAMTS13
5negative regulation of fibrinolysisGO:0519189.5THBD, APOH
6negative regulation of blood coagulationGO:0301959.4PROC, APOH, THBD
7blood coagulation, intrinsic pathwayGO:0075979.4APOH, VWF
8platelet degranulationGO:0025769.4VWF, SELP, ITGB3, ITGA2B
9leukocyte migrationGO:0509009.2ITGB3, PROC, SELP, THBD
10cell adhesionGO:0071559.1VWF, SELP, ITGB3, ITGA2B
11platelet activationGO:0301688.7VWF, THPO, MPL, SELP, ADAMTS13, ITGB3
12blood coagulationGO:0075966.0ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Molecular functions related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.4SELP, APOH, VWF
2protease bindingGO:0020209.3VWF, SERPINC1, F3
3heparin bindingGO:0082019.2SELP, SERPINC1, APOH
4identical protein bindingGO:0428029.1ITGA2B, ITGB3, APOH, VWF
5transmembrane signaling receptor activityGO:0048888.8THBD, MPL, FCGR2C, CD79A
6protein bindingGO:0055155.2ITGA2B, VWF, THBD, APOH, FCGR2C, SERPINC1

Products for genes affiliated with Purpura

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Sources for Purpura

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet