Summaries for Purpura

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Wikipedia:63 Purpura (from Latin: purpura, meaning \"purple\") are red or purple discolorations on the skin that do... more...

MalaCards based summary: Purpura, also known as purpuric disorder, is related to thrombotic thrombocytopenic purpura and lupus erythematosus. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Signal transduction by L1 and Ephrin B reverse signaling. The drugs epoprostenol and epoprostenol sodium and the compounds nadroparin and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Purpura

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Purpura, Aliases & Descriptions:

Name: Purpura 9 43 60
 
Purpuric Disorder 9


External Ids:

Disease Ontology9 DOID:3326
MeSH33 D011693
NCIt38 C78787

Related Diseases for Purpura

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Diseases related to Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 597)
idRelated DiseaseScoreTop Affiliating Genes
1thrombotic thrombocytopenic purpura32.7ADAMTS13
2lupus erythematosus31.2APOH, IFNA2
3hemolytic-uremic syndrome31.2VWF, THBD, ADAMTS13
4chickenpox31.1CD79A
5hepatitis31.1THPO, SELP, IFNA2
6mumps30.9CD79A
7central retinal vein occlusion30.8APOH
8thrombocytopenic purpura, autoimmune30.8THPO, MPL, SELP, IFNA2, ITGB3
9protein s deficiency30.8APOH, SERPINC1, F3
10polyarteritis nodosa30.7IFNA2
11portal vein thrombosis30.7THPO, SERPINC1
12thrombophlebitis30.6APOH
13retinal vein occlusion30.6APOH, SERPINC1
14factor xi deficiency, autosomal recessive30.6F3
15glanzmann thrombasthenia30.6ITGB3, ITGA2B
16cryoglobulinemia30.5APOH, IFNA2, CD79A
17membranoproliferative glomerulonephritis30.5CD79A, IFNA2
18thrombocytopenia, congenital amegakaryocytic30.5THPO, MPL
19meningococcemia30.5PROCR, SERPINC1, THBD
20sagittal sinus thrombosis30.4SERPINC1
21hellp syndrome30.4VWF, APOH, SERPINC1, ADAMTS13
22retinal artery occlusion30.4APOH
23hemolytic anemia30.3VWF, APOH, ADAMTS13, F3, IFNA2
24retinal vascular occlusion30.3APOH
25disseminated intravascular coagulation30.3THPO, THBD, SERPINC1, ADAMTS13, PROC, F3
26hemarthrosis30.3VWF, F3
27hypersplenism30.3THPO
28protein c deficiency30.2PROC, SERPINC1, APOH, THBD, PROCR
29bernard-soulier syndrome, type c30.2VWF, THPO, ITGB3, ITGA2B
30proliferative glomerulonephritis30.2SELP, CD79A
31leukemia30.2THPO, MPL, IFNA2, ITGB3, ITGA2B, CD79A
32vasculitis30.2VWF, THBD, APOH, SELP, IFNA2, CD79A
33afibrinogenemia30.2F3, VWF
34splenomegaly30.2THPO, MPL, IFNA2
35coronary thrombosis30.1VWF, SERPINC1, F3, ITGB3
36thrombophilia due to antithrombin iii deficiency30.1APOH, SERPINC1
37polycythemia30.1THPO, MPL, ITGB3
38syphilis30.1APOH, CD79A
39rheumatoid arthritis30.1CD79A, ITGB3, SELP, APOH, THPO
40severe pre-eclampsia30.1APOH, SERPINC1
41thrombotic thrombocytopenic purpura, acquired30.1THBD, VWF, APOH, SELP, F3, ADAMTS13
42ulcerative colitis30.1THPO, SELP, PROCR, CD79A
43proteinuria30.1CD79A, ADAMTS13, APOH
44eclampsia30.0SERPINC1, THBD
45connective tissue disease30.0VWF, THBD, APOH, F3, CD79A
46leukopenia30.0CD79A, IFNA2, F3
47lupus nephritis30.0CD79A, ADAMTS13, APOH, THBD
48factor vii deficiency30.0SERPINC1, F3
49galactosemia30.0THPO, SERPINC1, F3
50liver cirrhosis30.0IFNA2, F3, ADAMTS13, SERPINC1, THPO

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Symptoms for Purpura

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Drugs & Therapeutics for Purpura

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Drug clinical trials:

Search ClinicalTrials for Purpura

Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Purpura

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Anatomical Context for Purpura

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MalaCards organs/tissues related to Purpura:

31
Skin, T cells, Liver, Bone, Bone marrow, Endothelial, B cells, Kidney, Lung, Testes, Heart, Spleen, Prostate, Neutrophil, Colon, Breast, Monocytes, Brain, Thyroid, Pituitary, Retina, Smooth muscle, Lymph node, Cortex, Pancreas, Testis, Myeloid, Appendix, Pancreatic islet

Animal Models for Purpura or affiliated genes

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Publications for Purpura

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Articles related to Purpura:

(show top 50)    (show all 2419)
idTitleAuthorsYear
1
Fetal intracranial hemorrhage related to maternal autoimmune thrombocytopenic purpura. (24952237)
2014
2
Acute and fatal thrombocytopenic thrombotic purpura after a single dose of pemetrexed. (25370901)
2014
3
Ludwig's angina after severe thrombocytopenic purpura associated with dengue fever. (24603747)
2014
4
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
5
Thrombotic thrombocytopenic purpura in children. (23422353)
2013
6
Intravenous immunoglobulin in Henoch-SchAPnlein purpura complicated by cerebral hemorrhage. (22829413)
2013
7
Post-cardiac surgery thrombotic thrombocytopenic purpura with digital ischaemia. (23659403)
2013
8
Facial purpura associated with Capnocytophaga canimorsus septicaemia; role of sunlight? (23816547)
2013
9
Acquired thrombotic thrombocytopenic purpura (TTP) induced by silicone breast implants in 37-year old woman. (23477708)
2013
10
Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura. (23346910)
2013
11
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura. (24298390)
2013
12
Idiopathic thrombocytopenic purpura and hypokalaemic dRTA with compensated haemolysis and striking acanthocytosis in a band 3 (SLC4A1/AE1) A858D homozygote. (23053187)
2013
13
R1933X mutation in the MYH9 gene in May-Hegglin anomaly mimicking idiopathic thrombocytopenic purpura. (23759689)
2013
14
Inverse correlation of free and immune complex-sequestered anti-ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura. (22044668)
2012
15
Management of Thrombotic Thrombocytopenic Purpura with Autoantibodies to ADAMTS-13 and Concurrent Preeclampsia in Pregnancy: Multidisciplinary Team Approach. (23946903)
2012
16
Thrombotic thrombocytopenic purpura triggered by influenza A virus subtype H1N1 infection. (22094185)
2012
17
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
18
Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement. (21143648)
2011
19
Superior mesenteric artery syndrome: risk factor for duodenal involvement in Henoch-SchAPnlein purpura. (21129122)
2011
20
Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura. (21535387)
2011
21
Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. (20652968)
2010
22
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
23
Postoperative thrombotic thrombocytopenic purpura after open heart operations. (20103218)
2010
24
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
25
Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies. (19190804)
2009
26
Thrombopoietin-receptor agonists: a revolution in the therapeutic strategies of immune thrombocytopenic purpura?]. (19019500)
2009
27
Henoch-ShAPnlein purpura]. (19345173)
2009
28
Idiopathic thrombocytopenic purpura with isolated tuberculous splenic abscess. (19224070)
2009
29
Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (19317746)
2009
30
Plasma exchange therapy for thrombotic thrombocytopenic purpura in pediatric patients with liver transplantation. (18929799)
2008
31
HLA-DRB1 alleles and Henoch-SchAPnlein purpura: susceptibility and severity of disease. (18412308)
2008
32
Antioxidant enzyme activities, lipid peroxidation, and total antioxidant status in children with Henoch-SchAPnlein purpura. (17646900)
2008
33
Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis. (18339897)
2008
34
Unexpected superimposition of nutcracker effect in various conditions: is it an unrecognized confounding factor? Comment on: Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl. (Eur J Pediatr. 2006 Sep 29; [Epub ahead of print]). (17180389)
2007
35
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
36
Thrombotic thrombocytopenic purpura. (16102032)
2005
37
Clinical features and laboratory findings of thrombotic thrombocytopenic purpura associated with ticlopidine]. (16104532)
2005
38
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
39
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
40
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
41
Subacute painful quadriplegia and purpura. (14678939)
2003
42
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. (12877681)
2003
43
An update on the pathogenesis and management of acquired thrombotic thrombocytopenic purpura. (12858075)
2003
44
Henoch-SchAPnlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations. (12022354)
2002
45
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
46
Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenic purpura. (10755821)
2000
47
Henoch-SchAPnlein purpura with immunoglobulin A nephropathy and abnormalities of immunoglobulin A in a Wiskott-Aldrich syndrome carrier. (9016903)
1997
48
Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. (1791222)
1991
49
Successful treatment of neonatal purpura fulminans with epoprostenol. (1744852)
1991
50
Henoch-schoenlein purpura with colonic involvement. A case report. (6450111)
1980

Variations for Purpura

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Expression for genes affiliated with Purpura

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Search GEO for disease gene expression data for Purpura.

Pathways for genes affiliated with Purpura

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Pathways related to Purpura according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ITGA2B, ITGB3
29.8ITGA2B, ITGB3
3
Show member pathways
9.6THPO, ITGB3, ITGA2B
49.6THPO, ITGB3, ITGA2B
59.5VWF, ITGB3, ITGA2B
6
Show member pathways
9.2ITGA2B, ITGB3, SELP, VWF
7
Show member pathways
9.1THBD, SELP, PROC, ITGB3
89.0ITGA2B, ITGB3, IFNA2, VWF
9
Show member pathways
8.9VWF, THPO, MPL, ITGB3, ITGA2B
10
Show member pathways
8.9F3, PROC, SERPINC1, THBD
11
Show member pathways
8.8ITGA2B, ITGB3, IFNA2, MPL, THPO
12
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.5VWF, THBD, SERPINC1, PROC, F3
13
Show member pathways
8.5VWF, THBD, SERPINC1, PROC, F3
14
Show member pathways
6.5ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Compounds for genes affiliated with Purpura

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Compounds related to Purpura according to GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1nadroparin43 1210.5SERPINC1, SELP, F3
2sarpogrelate hydrochloride439.5SELP, THBD, SERPINC1
3hydroxyethyl starch439.4SERPINC1, VWF, SELP, F3
4ppack439.4VWF, SELP, F3, SERPINC1
5clopidogrel43 49 24 1212.2SELP, VWF, ITGB3, SERPINC1, F3
6bivalirudin43 1210.2THBD, SERPINC1, SELP, F3
7argatroban43 1210.2THBD, SELP, F3, SERPINC1
811-dehydrothromboxane b2439.1SELP, APOH, THBD, VWF
9dipyridamole43 59 28 1212.1VWF, F3, CD79A, SELP
10ristocetin439.1ITGB3, F3, ADAMTS13, SELP, SERPINC1, VWF
11iloprost59 28 43 1212.0SELP, THPO, F3, THBD, SERPINC1
12ptca438.9THBD, SELP, F3, APOH
13tirofiban43 129.9ITGA2B, ITGB3, F3, SELP, SERPINC1, VWF
14ticlopidine43 129.9SELP, F3, VWF, SERPINC1, APOH, ADAMTS13
15dermatan sulfate438.8SELP, SERPINC1, THBD, VWF, F3
16aprotinin43 129.7THBD, SELP, SERPINC1, VWF, F3
17cardiolipin43 129.7APOH, F3, CD79A, THBD
18txb2438.7VWF, THBD, SELP, F3, APOH
19desmopressin43 59 28 1211.7SERPINC1, SELP, THBD, VWF, F3, ADAMTS13
20thromboxane43 249.7VWF, SELP, MPL, THBD, THPO, APOH
21gamma-carboxyglutamic acid438.6THBD, F3, PROC, PROCR
22polyethylene glycol438.6IFNA2, SERPINC1, MPL, THPO, THBD, CD79A
23betacarotene438.6IFNA2, APOH, THBD, VWF, CD79A
24epinephrine43 24 1210.6SELP, F3, VWF, CD79A, THPO, IFNA2
25rituximab43 49 1210.6ADAMTS13, FCGR2C, APOH, CD79A, IFNA2, VWF
26citrate438.6CD79A, VWF, THBD, SERPINC1, SELP, F3
27polysaccharide438.5F3, SERPINC1, THPO, THBD, SELP, CD79A
28prednisolone43 28 1210.5THBD, APOH, VWF, CD79A, IFNA2
29kininogen438.5APOH, SERPINC1, SELP, THBD, F3, VWF
30homocysteine43 249.4SERPINC1, SELP, F3, THBD, VWF, APOH
31abciximab43 129.4ITGA2B, ITGB3, F3, SELP, SERPINC1, FCGR2C
32histamine43 28 2410.3IFNA2, THBD, VWF, THPO, CD79A, SELP
33agarose438.2APOH, VWF, THBD, THPO, IFNA2
34prostacyclin438.2SERPINC1, F3, SELP, APOH, VWF, THPO
35phosphatidylserine43 28 1210.2F3, THBD, VWF, APOH, SELP, ITGB3
36cyclophosphamide43 49 1210.2F3, IFNA2, APOH, THBD, ADAMTS13, VWF
37warfarin43 49 24 1211.0CD79A, F3, PROC, SELP, SERPINC1, APOH
38hirudin437.9THBD, THPO, VWF, SERPINC1, SELP, PROCR
39creatinine437.8SERPINC1, SELP, APOH, THPO, ADAMTS13, F3
40phospholipid437.7THBD, APOH, VWF, PROC, F3, PROCR
41steroid437.6CD79A, THPO, THBD, ITGB3, IFNA2, ADAMTS13
42estrogen437.6VWF, THPO, THBD, APOH, SERPINC1, ITGB3
43alanine437.5MPL, VWF, THPO, CD79A, SERPINC1, F3
44heparin43 28 24 1210.5ADAMTS13, F3, PROC, SELP, THPO, SERPINC1
45adp43 28 249.5ITGB3, SERPINC1, MPL, THBD, ITGA2B, VWF
46aspirin43 49 28 2410.4ITGB3, F3, SELP, SERPINC1, MPL, APOH
47cysteine437.2MPL, F3, CD79A, ITGA2B, ITGB3, IFNA2
48serine436.8PROC, PROCR, ADAMTS13, F3, ITGB3, ITGA2B
49fibrinogen436.1VWF, THPO, THBD, APOH, SELP, ADAMTS13
50vegf436.1SERPINC1, SELP, PROCR, F3, IFNA2, ITGB3

GO Terms for genes affiliated with Purpura

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Cellular components related to Purpura according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:00083059.8ITGA2B, ITGB3
2platelet alpha granule membraneGO:00310929.7SELP, ITGB3, ITGA2B
3external side of plasma membraneGO:00098979.3VWF, SELP, ITGA2B, CD79A
4extracellular matrixGO:00310129.0F3, APOH, VWF
5cell surfaceGO:00099868.7THBD, APOH, ADAMTS13, F3
6integral component of plasma membraneGO:00058877.8THBD, MPL, SELP, PROCR, ITGB3, ITGA2B
7extracellular spaceGO:00056157.6IFNA2, F3, ADAMTS13, SELP, SERPINC1, APOH
8plasma membraneGO:00058867.0THBD, MPL, FCGR2C, SERPINC1, SELP, PROC

Biological processes related to Purpura according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1platelet aggregationGO:00705279.8ITGA2B, ITGB3
2positive regulation of leukocyte migrationGO:00026879.8ITGA2B, SELP
3integrin-mediated signaling pathwayGO:00072299.8ADAMTS13, ITGB3, ITGA2B
4cell-matrix adhesionGO:00071609.7ITGA2B, ITGB3, ADAMTS13
5negative regulation of fibrinolysisGO:00519189.5THBD, APOH
6negative regulation of blood coagulationGO:00301959.4PROC, APOH, THBD
7blood coagulation, intrinsic pathwayGO:00075979.4APOH, VWF
8platelet degranulationGO:00025769.4VWF, SELP, ITGB3, ITGA2B
9leukocyte migrationGO:00509009.2ITGB3, PROC, SELP, THBD
10cell adhesionGO:00071559.1VWF, SELP, ITGB3, ITGA2B
11platelet activationGO:00301688.7VWF, THPO, MPL, SELP, ADAMTS13, ITGB3
12blood coagulationGO:00075966.0ITGA2B, VWF, THPO, THBD, MPL, SERPINC1

Molecular functions related to Purpura according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.4SELP, APOH, VWF
2protease bindingGO:00020209.3VWF, SERPINC1, F3
3heparin bindingGO:00082019.2SELP, SERPINC1, APOH
4identical protein bindingGO:00428029.1ITGA2B, ITGB3, APOH, VWF
5transmembrane signaling receptor activityGO:00048888.8THBD, MPL, FCGR2C, CD79A
6protein bindingGO:00055155.2ITGA2B, VWF, THBD, APOH, FCGR2C, SERPINC1

Products for genes affiliated with Purpura

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Sources for Purpura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet