MCID: PRP030
MIFTS: 60

Purpura malady

Summaries for Purpura

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on... more...

MalaCards: Purpura, also known as purpuric disorder, is related to purpura fulminans and autoimmune thrombocytopenic purpura. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Collagen biosynthesis and modifying enzymes and Platelet activation, signaling and aggregation. The drugs epoprostenol and epoprostenol sodium and the compounds fibrinogen and cysteine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Purpura

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

purpura 8 45 61
purpuric disorder 8
purpura nos 8


External Ids:

Disease Ontology8 DOID:3326
MeSH35 D011693
NCIt40 C78787

Related Diseases for Purpura

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 553)
idRelated DiseaseScoreTop Affiliating Genes
1purpura fulminans31.5SERPINC1, PROC, PROCR, F5
2autoimmune thrombocytopenic purpura31.4SELP, THPO, IL11, MPL, ITGB3, IFNA2
3thrombotic thrombocytopenic purpura, acquired31.1ADAMTS13, SELP, THBD, THBS1, VWF, F3
4nephritis31.0CD79A, CD40LG, APOH
5hemolytic-uremic syndrome30.9ADAMTS13, THBD, VWF
6thrombocytopenia30.8ADAMTS13, SERPINC1, SELP, THPO, THBD, VWF
7sepsis30.8ADAMTS13, SERPINC1, SELP, THBD, F3, IL11
8systemic lupus erythematosus30.8ADAMTS13, THBD, FCGR2C, VWF, F3, CD79A
9vasculitis30.7SELP, THBD, VWF, CD79A, CD40LG, APOH
10hepatitis c30.6THPO, CD40LG, IFNA2
11protein c deficiency30.6SERPINC1, THBD, PROC, PROCR, F5, APOH
12protein s deficiency30.6SERPINC1, F3, F5, APOH
13meningococcemia30.5SERPINC1, THBD, PROCR, F5
14autoimmune hemolytic anemia30.4CD79A, CD40LG
15septic shock30.4SERPINC1, THBD, F3, F5
16antiphospholipid syndrome30.4ADAMTS13, SERPINC1, SELP, THBD, VWF, F3
17polyarteritis nodosa30.3IFNA2
18mixed connective tissue disease30.3APOH
19cryoglobulinemia30.2CD79A, CD40LG, APOH, IFNA2
20arthritis30.2THBS1
21hellp syndrome30.1ADAMTS13, SERPINC1, VWF, F5, APOH
22ulcerative colitis30.1SELP, THPO, IL11, CD79A, PROCR
23hepatitis b30.1CD79A, IFNA2
24aplastic anemia30.1THPO, IL11, MPL
25wiskott-aldrich syndrome30.1THPO
26mumps30.1CD79A
27measles30.1CD79A, CD40LG
28lupus nephritis30.0ADAMTS13, THBD, CD79A, CD40LG, APOH
29coronary thrombosis30.0SERPINC1, VWF, F3, ITGB3
30portal vein thrombosis30.0SERPINC1, THPO, F5
31stroke, ischemic30.0F5, ITGA2B
32central retinal vein occlusion30.0F5, APOH
33adenocarcinoma30.0THBD, THBS1
34membranoproliferative glomerulonephritis30.0CD79A, IFNA2
35thrombocytosis30.0SERPINC1, SELP, THPO, THBD, VWF, F3
36pregnancy loss30.0SERPINC1, F3, CD40LG, F5, APOH
37acute leukemia30.0THPO, IL11, MPL
38sickle cell disease30.0SELP, THBS1, VWF
39systemic scleroderma30.0THBD, VWF, CD40LG, APOH
40viral hepatitis29.9IFNA2
41evans' syndrome29.9ADAMTS13
42thrombophilia29.8SERPINC1, SELP, THBD, VWF, F3, PROC
43deficiency anemia29.8ADAMTS13, THPO, VWF, F3, IL11, CD79A
44coronary artery disease,29.8ADAMTS13, SELP, THPO, THBD, VWF, F3
45vascular disease29.8SERPINC1, SELP, THBD, VWF, F3, F5
46acute myocardial infarction29.8ADAMTS13, SERPINC1, SELP, THBD, VWF, F3
47leukopenia29.8F3, IL11, CD79A, IFNA2
48splenomegaly29.8THPO, MPL, IFNA2
49cryoglobulinemic vasculitis29.8CD40LG, IFNA2
50rheumatic disease29.8IL11, CD40LG, APOH

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Clinical Features for Purpura

Drugs & Therapeutics for Purpura

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Purpura

Drug clinical trials:

Search ClinicalTrials for Purpura

Search NIH Clinical Center for Purpura

Search CenterWatch for Purpura

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Purpura

Anatomical Context for Purpura

Animal Models for Purpura or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Purpura

Sources:
51PubMed
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Articles related to Purpura:

(show top 50)    (show all 2356)
idTitleAuthorsYear
1
Purpura with ulcerative skin lesions and mixed cryoglobulinemia in a quiescent hepatitis B virus carrier. (24429450)
2014
2
Characterization of the complications associated with plasma exchange for thrombotic thrombocytopaenic purpura and related thrombotic microangiopathic anaemias: a single institution experience. (24117855)
2014
3
Prolongation of idiopathic thrombocytopenic purpura associated with paroxetine administration. (22832136)
2013
4
Pain, purpura and curly hairs. (23905675)
2013
5
Ulcerative colitis accompanied by idiopathic thrombocytopenic purpura and Helicobacter pylori infection. (23448762)
2013
6
Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry. (23715103)
2013
7
Rituximab maintenance for relapsed refractory thrombotic thrombocytopenic purpura. (22486316)
2012
8
Podocalyxin expression in renal tissues and correlation with the number of urinary podocytes in children with Henoch-Schonlein purpura nephritis. (22561433)
2012
9
Seasonal association of thrombotic thrombocytopenic purpura. (22242922)
2012
10
Autoimmune disorders in patients with idiopathic thrombotic thrombocytopenic purpura. (22960981)
2012
11
Refractory Thrombotic Thrombocytopenic Purpura Associated With Primary Sjogren Syndrome Treated With Rituximab: A Case Report. (23011161)
2012
12
Photoclinic. Streptococcal purpura fulminans. (22292586)
2012
13
Empiric treatment of protracted idiopathic purpura fulminans in an infant: a case report and review of the literature. (21605440)
2011
14
Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. (20652968)
2010
15
Thrombopoietin-receptor agonists: a revolution in the therapeutic strategies of immune thrombocytopenic purpura?]. (19019500)
2009
16
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
17
Gene polymorphism of vascular endothelial growth factor in children with Henoch-Schonlein purpura nephritis. (19558800)
2009
18
Cerebral vasculitis and nephritis in a child: complicated Henoch-Schonlein purpura or a rare case of Wegener's granulomatosis? (19317764)
2009
19
HLA class 1 associations in Henoch Schonlein purpura: increased and decreased frequencies. (17487448)
2008
20
Congenital thrombotic thrombocytopenic purpura: Lessons for recognition and management of rare syndromes. (18360884)
2008
21
Neutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-SchAPnlein purpura. (17404760)
2007
22
Decreased factor XIII activity during severe Henoch-Schoenlein purpura -- does it play a role? (16688675)
2006
23
Thrombotic thrombocytopenic purpura: a moving target. (17124092)
2006
24
Intravenous immunoglobulin for autoimmune thrombocytopenic purpura. (15866702)
2005
25
Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies. (16137345)
2005
26
Successful treatment of crescentic glomerulonephritis associated with adult-onset Henoch-Schoenlein purpura by double-filtration plasmapheresis. (15077873)
2004
27
Helicobacter pylori infection in patients with autoimmune thrombocytopenic purpura. (15237446)
2004
28
Splenunculectomy in autoimmune thrombocytopenic purpura. (14616992)
2003
29
Henoch-SchAPnlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations. (12022354)
2002
30
Thrombotic thrombocytopenic purpura and bone marrow necrosis as a complication of gastric neoplasm. (11801475)
2002
31
Anesthetic management of cesarean section for a patient with idiopathic thrombocytopenic purpura]. (10998889)
2000
32
Acute renal failure in an adult patient with Henoch-Schoenlein purpura after episode of macroscopic hematuria. (10048122)
1999
33
Recombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans. (9590330)
1998
34
Management strategy in purpura fulminans with multiple organ failure in children. (8719318)
1996
35
Epidural sympathetic blockade to relieve vascular insufficiency in an infant with purpura fulminans. (8375170)
1993
36
Platelet-agglutinating protein p37 from a thrombotic thrombocytopenic purpura plasma forms complexes with platelet membrane glycoprotein IV (CD36). (1384492)
1992
37
Purpura and recurrent ulcers on the lower extremities. Essential cryofibrinogenemia. (1986695)
1991
38
Purpura fulminans and transient protein C and S deficiency. (2970826)
1988
39
Idiopathic thrombocytopenic purpura in a patient with Laurence-Moon-Bardet-Biedl syndrome. (3397311)
1988
40
Cartilage hair hypoplasia with thrombocytopenic purpura, autoimmune haemolytic anaemia and cell-mediated immunodeficiency. (3950893)
1986
41
Neonatal alloimmune thrombocytopenic purpura and congenital porencephaly in two siblings associated with a "new" maternal antiplatelet antibody. (2581641)
1985
42
Platelet function in idiopathic (autoimmune) thrombocytopenic purpura. (4077821)
1985
43
Cutaneous leukocytoclastic vasculitis with hyperglobulinemia and splenomegaly. A variant of hyperglobulinemic purpura of WaldenstrAPm. (6206803)
1984
44
SjAPgren,'s syndrome and benign hyperglobulinemic purpura of Waldenstrom. (7325506)
1981
45
Autoimmune thrombocytopenic purpura. (6157441)
1980
46
Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). (4672230)
1972
47
Vaccination and Henoch-Schoenlein purpura. (5813014)
1969
48
Purpura fulminans associated with septicaemia. (6080580)
1967
49
Familial hereditary purpura simplex with SchAPnlein-Henoch syndrome; response to corticotropin (ACTH), cortisone, and antihistaminics. (13242408)
1955
50
Bullous Purpura following Impetigo. (19973963)
1909

Genetic Variations for Purpura

Expression for genes affiliated with Purpura

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for genes affiliated with Purpura

Sources:
54Reactome, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB
See all sources

Pathways related to Purpura according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1ITGB3, ITGA2B, F5, PROC, F3, THBS1
2
Hide members
11.0IFNA2, ITGB3, ITGA2B, F5, MPL, PROC
3
Hide members
10.9F3, VWF, THBS1, THBD, THPO, SELP
4
Hide members
10.9SERPINC1, THBD, VWF, F3, PROC, F5
5
Hide members
10.9F5, PROC, F3, VWF, THBD, SERPINC1
6
Hide members
10.9ITGB3, ITGA2B, F5, VWF, THBS1, SELP
7
Hide members
10.9IFNA2, ITGB3, ITGA2B, MPL, IL11, THPO
8
Hide members
10.9ITGB3, ITGA2B, MPL, VWF, THPO
9
Hide members
10.9F5, PROC, F3, THBD, SERPINC1
1010.9THBS1, VWF, ITGA2B, ITGB3, IFNA2
1110.8SELP, THBD, PROC, ITGB3
1210.8ITGB3, ITGA2B, IL11, THPO
13
Hide members
10.8THBS1, VWF, ITGA2B, ITGB3
1410.7VWF, ITGA2B, ITGB3
15
Hide members
10.7VWF, ITGA2B, ITGB3
16
Hide members
10.7ITGB3, ITGA2B, VWF
1710.7ITGB3, CD40LG, SELP

Compounds for genes affiliated with Purpura

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 208)
idCompoundScoreTop Affiliating Genes
1fibrinogen4512.2CD79A, IL11, F3, VWF, THBS1, THBD
2cysteine4512.0F3, IL11, CD79A, CD40LG, MPL, F5
3vegf4511.9SERPINC1, SELP, THPO, THBD, THBS1, VWF
4alanine4511.9CD40LG, THBS1, VWF, F3, CD79A, THBD
5aspirin45 50 29 2414.9CD79A, F3, VWF, THBD, THPO, SELP
6hirudin4511.7THPO, SELP, SERPINC1, F5, PROCR, CD40LG
7polyethylene glycol4511.6CD40LG, MPL, F5, IFNA2, CD79A, IL11
8retinoic acid45 2412.6CD40LG, F5, IFNA2, THPO, SELP, IL11
9cyclophosphamide45 50 1113.6F3, F5, APOH, IFNA2, IL11, THBS1
10prostacyclin4511.6THBS1, THBD, F3, F5, APOH, THPO
11epinephrine45 11 2413.6SELP, THPO, VWF, IFNA2, F5, CD40LG
12polysaccharide4511.5SELP, THBS1, CD79A, CD40LG, F5, THBD
13abciximab45 1112.5SERPINC1, SELP, FCGR2C, VWF, ITGB3, ITGA2B
14creatinine4511.5ADAMTS13, SELP, THPO, THBD, F3, APOH
15ristocetin4511.5SERPINC1, ADAMTS13, ITGB3, F5, F3, VWF
16tirofiban45 1112.5ITGB3, ITGA2B, CD40LG, F3, VWF, SELP
17heparin45 29 11 2414.5SELP, ADAMTS13, THPO, IL11, CD79A, CD40LG
18endotoxin4511.5ADAMTS13, THBD, F3, IL11, CD40LG, PROCR
19desmopressin45 60 29 1114.4F5, F3, VWF, THBD, SELP, SERPINC1
20txb24511.4THBD, SELP, IL11, VWF, F3, THBS1
21rituximab45 50 1113.4ADAMTS13, FCGR2C, IFNA2, APOH, CD40LG, CD79A
22warfarin45 50 11 2414.4SERPINC1, SELP, VWF, CD79A, PROC, APOH
23kininogen4511.4F5, F3, SERPINC1, THBS1, APOH, VWF
24ticlopidine45 1112.3SERPINC1, ADAMTS13, VWF, SELP, F3, APOH
25homocysteine45 2412.3F3, VWF, THBD, SELP, APOH, SERPINC1
26citrate4511.3THBD, SERPINC1, CD79A, F5, F3, SELP
27clopidogrel50 45 11 2414.3ITGB3, CD40LG, F3, VWF, SELP, SERPINC1
28histamine45 29 2413.3THBD, VWF, IL11, CD79A, CD40LG, IFNA2
29mycophenolate mofetil45 50 1113.3THBD, IL11, F5, CD40LG, CD79A, SELP
30hyaluronic acid45 2412.3THPO, CD40LG, CD79A, IL11, VWF, THBS1
31dextran sulfate4511.3F5, CD40LG, THBS1, SELP, APOH
32dermatan sulfate4511.3SERPINC1, SELP, THBD, F3, F5, VWF
33thromboxane45 2412.2THPO, SELP, THBD, VWF, MPL, APOH
34serine4511.2ADAMTS13, ITGA2B, THBS1, MPL, PROCR
35phosphatidylserine45 29 1113.2CD79A, F3, ITGB3, APOH
36bivalirudin45 1112.2SELP, F5, F3, THBD, SERPINC1
37argatroban45 1112.2SERPINC1, SELP, F5, F3, THBD
38ppack4511.2CD40LG, SELP, F3, VWF, SERPINC1
39folate4511.2CD79A, VWF, SERPINC1, CD40LG, F5, APOH
40gamma-carboxyglutamic acid4511.1THBD, PROC, PROCR, F5, F3
41estrogen4511.1THPO, CD79A, APOH
42adp45 29 2413.1PROC, CD40LG, ITGA2B, MPL
43cyclosporin a45 29 6013.1ADAMTS13, SELP, THBD, THBS1, VWF, IL11
44aprotinin45 1112.1SERPINC1, F5, F3, VWF, SELP, THBD
45ximelagatran45 1111.9F3, SERPINC1, F5, THBD
46iloprost45 60 29 1113.9F3, SERPINC1, SELP, THPO, THBD
47heparinoids4510.9F5, F3, SERPINC1, THBD
48aspartate4510.9CD40LG, IL11
49fondaparinux4510.7THBD, SERPINC1, F3, F5
50gamma globulin4510.3IFNA2, VWF

GO Terms for genes affiliated with Purpura

Sources:
16Gene Ontology
See all sources

Cellular components related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6PROC, MPL, F5, ITGA2B, ITGB3, CD40LG
2extracellular spaceGO:00561511.6ADAMTS13, IFNA2, APOH, F5, CD40LG, IL11
3external side of plasma membraneGO:00989711.2ITGA2B, CD40LG, CD79A, VWF, THBS1, SELP
4integral to plasma membraneGO:00588711.0ITGB3, ITGA2B, MPL, PROCR, CD40LG, THBD
5extracellular regionGO:00557611.0SERPINC1, THBS1, VWF, IL11, PROC, F5
6cell surfaceGO:00998611.0APOH, F3, THBS1, THBD, ADAMTS13
7platelet alpha granule membraneGO:03109210.9SELP, ITGA2B, ITGB3
8extracellular matrixGO:03101210.9THBS1, VWF, F3, APOH
9platelet alpha granule lumenGO:03109310.6THBS1, VWF, F5
10platelet alpha granuleGO:03109110.3VWF, THBS1

Biological processes related to Purpura according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.8SERPINC1, IFNA2, ITGB3, SELP, THPO, THBD
2platelet activationGO:03016811.6ADAMTS13, SELP, THPO, THBS1, VWF, IL11
3platelet degranulationGO:00257611.2ITGB3, ITGA2B, F5, VWF, THBS1, SELP
4cell adhesionGO:00715511.1ITGB3, ITGA2B, F5, VWF, THBS1, SELP
5leukocyte migrationGO:05090010.9SELP, THBD, PROC, ITGB3
6negative regulation of fibrinolysisGO:05191810.9APOH, THBS1, THBD
7negative regulation of blood coagulationGO:03019510.9THBD, PROC, APOH
8B cell differentiationGO:03018310.8CD40LG, CD79A, IL11
9integrin-mediated signaling pathwayGO:00722910.8ADAMTS13, ITGA2B, ITGB3
10cell-matrix adhesionGO:00716010.7ITGB3, ITGA2B, ADAMTS13
11B cell proliferationGO:04210010.6CD79A, CD40LG
12positive regulation of endothelial cell apoptotic processGO:200035310.5THBS1, CD40LG
13positive regulation of blood coagulationGO:03019410.3THBS1, APOH

Molecular functions related to Purpura according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8PROCR, F5, ITGA2B, ITGB3, APOH, IFNA2
2glycoprotein bindingGO:00194811.0SELP, THBS1, VWF, APOH
3transmembrane signaling receptor activityGO:00488810.9MPL, CD79A, FCGR2C, THBD
4heparin bindingGO:00820110.9APOH, THBS1, SELP, SERPINC1
5cytokine activityGO:00512510.8THPO, IL11, CD40LG, IFNA2
6integrin bindingGO:00517810.7ADAMTS13, THBS1, VWF
7protease bindingGO:00202010.6F3, VWF, SERPINC1
8identical protein bindingGO:04280210.6THBS1, VWF, ITGA2B, ITGB3, APOH

Products for genes affiliated with Purpura

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Purpura

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet