Purpura malady

Wikipedia: Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on...⁴⁴ more...

MalaCards: Purpura, also known as purpura (morphologic abnormality), is related to purpura fulminans and thrombotic thrombocytopenic purpura, acquired. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Phagosome and Staphylococcus aureus infection. The drugs epoprostenol and epoprostenol sodium and the compounds alemtuzumab and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and cortex, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Descriptions:

purpura 6 8 32 43 purpura (morphologic abnormality) 6

purpuric disorder 6 purpura nos 6

Diseases related to purpura by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1004)

id	Related Disease	Score	Top Affiliating Genes
1	purpura fulminans	36.6	SERPINC1, MTHFR, APOH, F5, F3, F2
2	thrombotic thrombocytopenic purpura, acquired	36.0	VWF, SELE, SELP, SERPINE1, CFH, CD46
3	henoch-schoenlein purpura	36.0	VCAM1, MX1, MPO, CD79A, MEFV, ICAM1
4	autoimmune thrombocytopenic purpura	35.9	VWF, MPL, ITGA2B, ITGB3, FCGR1A, FCGR2A
5	protein c deficiency	32.7	SERPINC1, SERPINF2, SERPINE1, MTHFR, APOH, F9
6	hemolytic-uremic syndrome	31.6	RECK, VWF, SELP, SERPINC1, SERPINE1, CFB
7	protein s deficiency	31.3	RECK, SERPINC1, SERPINE1, MTHFR, CD9, IL2
8	systemic lupus erythematosus	30.8	RECK, VWF, SELE, VCAM1, MX1, S100A8
9	hepatitis	30.7	SELP, SEPSECS, IL2RB, FASLG, FAS, IFNA1
10	aplastic anemia	30.4	MPL, IL11, FASLG, FAS, GP1BA, IFNG
11	disseminated intravascular coagulation	30.3	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, VEGFA
12	thrombocytopenia	30.2	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1
13	meningococcemia	29.8	SERPINC1, SERPINE1, IL1A, IL1B, IL1RN, F5
14	essential thrombocythemia	29.2	VWF, SELP, MPL, IL11, IFNA1, IFNA2
15	liver cirrhosis	28.9	SERPINC1, SERPINF2, SEPSECS, LACTB, IL11, GP1BA
16	hemolytic anemia	28.9	VWF, LACTB, CFH, APOH, IFNA2, F3
17	thrombophilia	28.4	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
18	hemophilia	28.4	VWF, SELP, SERPINC1, MTHFR, CD40LG, CD9
19	immunodeficiency	28.2	BMP6, CFLAR, CD79A, CD40LG, CD80, CD40
20	acute lymphoblastic leukemia	28.2	RECK, SERPINC1, MTHFR, MPL, MPO, CD5
21	myelodysplastic syndrome	28.0	CFLAR, MPL, MPO, IL11, IL1A, FASLG
22	angioedema	27.9	SERPINC1, MME, IL2, IL5, IL6, IGHE
23	hepatitis c	27.8	MX1, CD40LG, IL10, IL12B, IL18, IL2
24	malignant hypertension	27.8	VWF, APOH, EDN1, ACE, AGT, AGTR1
25	food allergy	27.7	S100A8, FOXP3, IL13, IL4, IL5, CCL11
26	iga glomerulonephritis	27.7	SELE, BMP6, SCGB1A1, CFH, CD79A, CD40LG
27	lymphoproliferative syndrome	27.7	CD40LG, CD5, IL10, IL2, IL2RA, FASLG
28	nephritis	27.6	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
29	septic shock	27.5	SELE, SERPINC1, SERPINE1, LACTB, FCGR1A, IL10
30	autoimmune lymphoproliferative syndrome	27.3	IL10, IL2RA, FASLG, FAS, IGHE, TNFSF10
31	autoimmune hemolytic anemia	27.2	VWF, MPO, CD79A, CD40LG, IL10, IL17A
32	antiphospholipid syndrome	27.1	VWF, SELE, SELP, SERPINC1, SERPINE1, VEGFA
33	rheumatoid vasculitis	27.1	SELE, VCAM1, ICAM1, HLA-DRB1, TNF, SRF
34	connective tissue disease	27.0	VWF, SELE, VCAM1, BMP6, S100A8, MPO
35	mixed connective tissue disease	26.9	S100A8, CD40LG, MICA, IL6, APOH, HSPG2
36	cryoglobulinemia	26.3	VWF, SELE, VCAM1, BMP6, MX1, CD79A
37	crescentic glomerulonephritis	26.0	VCAM1, BMP6, SCGB1A1, MPO, CD79A, CD36
38	sepsis	25.6	RECK, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
39	fasciitis	25.4	BMP6, CD46, IL10, IL5, IGHE, IFNA1
40	proteinuria	24.8	VWF, SELP, SERPINC1, SERPINE1, VEGFA, VCAM1
41	vascular disease	24.7	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1
42	anemia	24.6	VWF, SELE, SELP, SERPINC1, NAAA, VEGFA
43	wilson disease	24.5	MTHFR, CD79A, IL1A, IL1B, IL1RN, IL6
44	familial mediterranean fever	24.5	SELP, SERPINC1, SERPINE1, VEGFA, LEP, MICA
45	crohn's disease	24.1	MPO, CD80, FOXP3, IL10, IL11, IL12B
46	thrombosis	24.1	RECK, VWF, SELE, SELP, SERPINC1, SERPINF2
47	rheumatic fever	24.0	CD79A, CD40LG, FCGR2A, IL1A, IL1B, IL2
48	nephropathy	24.0	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
49	eosinophilia	23.9	VCAM1, MPO, CD79A, CD86, ITGB2, FOXP3
50	glomerulonephritis	23.8	VWF, SELP, SERPINC1, SERPINF2, SERPINE1, VEGFA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 epoprostenol, epoprostenol sodium

MalaCards organs/tissues related to purpura:

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MGI Mouse Phenotypes related to purpura:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.9	SELP, SCGB1A1, ITGB3, FOXG1, FCGR2B, IL12A
2	hematopoietic system phenotype	MP:0005397	10.8	BMP4, CFLAR, MPL, JAG1, CD86, CD72
3	endocrine/exocrine gland phenotype	MP:0005379	10.6	PAX2, CD40LG, FOXG1, FGFR2, IL2, IL2RB
4	embryogenesis phenotype	MP:0005380	10.4	RECK, SERPINC1, CFLAR, MPL, FOXG1, FGFR2
5	immune system phenotype	MP:0005387	9.9	VWF, SELP, CFB, CFLAR, MPL, CD79A
6	craniofacial phenotype	MP:0005382	9.9	BMP4, JAG1, FOXG1, FOXP3, FGFR2, IL12B
7	growth/size phenotype	MP:0005378	9.8	RECK, SELE, SELP, SERPINE1, VCAM1, BMP4
8	other phenotype	MP:0005395	9.8	RECK, CD40LG, ITGB3, MME, IL13, IL2
9	renal/urinary system phenotype	MP:0005367	9.8	SELP, BMP4, PAX2, SCGB1A1, CFB, CFH
10	no phenotypic analysis	MP:0003012	9.6	VEGFA, VCAM1, BMP4, MTHFR, JAG1, CD79A
11	normal phenotype	MP:0002873	9.0	SELE, VEGFA, BMP4, SCGB1A1, CFB, CFH
12	digestive/alimentary phenotype	MP:0005381	8.9	VWF, VEGFA, BMP4, LEP, JAG1, CD36
13	limbs/digits/tail phenotype	MP:0005371	8.6	RECK, VEGFA, BMP4, LEP, MTHFR, MMP9
14	behavior/neurological phenotype	MP:0005386	8.2	SELE, SELP, BMP4, LEP, JAG1, CD86
15	skeleton phenotype	MP:0005390	8.1	RECK, VEGFA, BMP4, BMP6, LEP, MTHFR
16	reproductive system phenotype	MP:0005389	8.0	VEGFA, PAX2, LEP, CD46, ITGA2B, MMP9
17	hearing/vestibular/ear phenotype	MP:0005377	7.8	BMP4, PAX2, JAG1, FOXG1, FOXP3, FGF2
18	vision/eye phenotype	MP:0005391	7.1	SELE, SELP, SERPINC1, VEGFA, BMP4, PAX2
19	adipose tissue phenotype	MP:0005375	6.3	SERPINE1, LEP, CD36, FGFR2, IL18, IL1R1
20	muscle phenotype	MP:0005369	5.4	VEGFA, BMP4, LEP, CFLAR, MPO, JAG1
21	tumorigenesis	MP:0002006	5.4	SERPINE1, SCGB1A1, LEP, ITGB3, MMP9, FGF2
22	cellular phenotype	MP:0005384	5.4	VWF, SELE, SELP, VEGFA, VCAM1, BMP4
23	homeostasis/metabolism phenotype	MP:0005376	INF	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
24	cardiovascular system phenotype	MP:0005385	INF	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1
25	liver/biliary system phenotype	MP:0005370	INF	RECK, SERPINC1, VEGFA, BMP4, CD36, MEFV
26	integument phenotype	MP:0010771	INF	RECK, SELP, ITGA2, ITGB2, ITGB3, MME
27	nervous system phenotype	MP:0003631	INF	RECK, VWF, SELP, SERPINC1, BMP4, PAX2
28	mortality/aging	MP:0010768	INF	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1

Articles related to purpura:

(show top 50)    (show all 535)

id	Title	Authors	Year	Affiliating Genes
1	A novel homozygous missense ADAMTS13 mutation Y658C in a patient with recurrent thrombotic thrombocytopenic purpura. (22075512)	Lee S.H.... Kim S.R.	2011	ADAMTS13
2	MEFV E148Q polymorphism is associated with Henoch-Sch APnlein purpura in Chinese children. (20602240)	He X.... Heng C.K.	2010	MEFV
3	Protein C (PROC) gene mutations in two Indian familie s with purpura fulminans. (20077116)	Pai N.... Ghosh K.	2010	PROC
4	Relationship between integrin-linked kinase expressi on and renal glomerular damage in children with Henoch-Schnlein purpura nephrit is (20113654)	Li Z.H.... Liu Z.Q.	2009	ILK
5	Serum and urine VEGF concentration of different path ological types in children with Henoch Schonlein purpura nephritis]. (20045916)	Peng S.... Dang X.	2009	VEGFA
6	The role of T-cell immunoglobulin- and mucin-domain-containing molecule-3 polymorphisms in idiopathic thrombocytopenic purpura. (19332093)	Du W.T.... Yang R.C.	2009	HAVCR2
7	High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura. (19797730)	Shan N.N.... Hou M.	2009	IL18, IL4, IL18BP
8	Effect of paraoxonase 1 gene polymorphisms on clinica l course of Henoch-SchAPnlein purpura. (19967651)	Yilmaz A.... Sirin A.	2009	PON1
9	Case of chronic type C hepatitis complicated with idiopathic thrombocytopenic purpura that was successfully treated by interferon therapy (19262055)	Karasawa T.... Kawata S.	2009	IFNB1
10	Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. (18683034)	Tao J.... Yang R.	2008	DNMT3B, AHCY, DNMT3A
11	Modern concepts of the diagnosis and treatment of purpura fulminans. (18652566)	Edlich R.F.... Long W.B.	2008	SERPINC1
12	New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura. (18211568)	Kuter D.J.	2008	THPO, MPL
13	CD72 Polymorphism Associated with Child-Onset of Idiopathic Thrombocytopenic Purpura in Chinese Patients. (18071878)	Xu J.... Yang R.	2007	CD72
14	The role of chemokines in Henoch Schonlein Purpura. (17387476)	Tahan F.... Dusunsel R.	2007	CCL11, CXCR3, CCL17
15	Molecular characterization of four ADAMTS13 mutations responsible for congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome). (17849048)	Hommais A.... Ribba A.S.	2007	ADAMTS13
16	Novel heterozygous missense mutation in the second leucine rich repeat of GPIbalpha affects GPIb/IX/V expression and results in macrothrombocytopenia in a patient initially misdiagnosed with idiopathic thrombocytopenic purpura. (16519708)	Kunishima S.... Saito H.	2006	GP1BA
17	Thrombopoietin and interleukin-6 levels in Henoch-SchAPnlein purpura. (17164950)	Lin C.Y.... Chiang B.L.	2006	IL6, THPO
18	Chronic refractory idiopathic thrombocytopenic purpura (ITP) and anti-CD20 monoclonal antibody: a case report. (17000895)	Latifzadeh S.Z.... Entezari V.	2006	MS4A1
19	Acquired amegakaryocytic thrombocytopenic purpura. (16432869)	Agarwal N.... Rodgers G.M.	2006	IL11
20	ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura. (16676082)	Tsai H.M.... Rand J.H.	2006	ADAMTS13
21	Effect of protein kinase C on proliferation and apoptosis of T lymphocytes in idiopathic thrombocytopenic purpura children. (16212887)	Wu C.... Cai K.	2005	FASLG
22	Thrombotic thrombocytopenic purpura without schistocytes on the peripheral blood smear. (15813170)	Daram S.R.... Bastani B.	2005	HP
23	Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). (15327386)	Licht C.... Hoppe B.	2004	ADAMTS13
24	Nine years of cascade filtration for thrombotic thrombocytopenic purpura. (15255122)	Valbonesi M.... Giannini G.	2004	CD40LG
25	Thrombotic thrombocytopenic purpura with severe ADAMT S-13 deficiency in two patients with primary antiphospholipid syndrome. (15476241)	Amoura Z.... Piette J.C.	2004	APOH
26	Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13. (14512317)	Pimanda J.E.... Hogg P.J.	2004	ADAMTS13
27	Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. (14707707)	Manco-Johnson M.J.... Knapp-Clevenger R.	2004	F5
28	The association between transforming growth factor-beta gene promoter C-509T polymorphism and Chinese children with Henoch-Schonlein purpura. (15257453)	Yang Y.H.... Chiang B.L.	2004	TGFB1, TNF
29	von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. (12130486)	Remuzzi G.... Mannucci P.M.	2002	ADAMTS13
30	Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch-Schonlein purpura. (12136897)	Amoli M.M.... Gonzalez-Gay M.A.	2002	IL1R1, IL1RN
31	Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor. (12384150)	Shibuya K.... Miyazaki H.	2002	THPO
32	Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch-Schonlein purpura. (11361181)	Amoli M.M.... Gonzalez-Gay M.A.	2001	ICAM1
33	Overview of idiopathic thrombocytopenic purpura: new approach to refractory patients. (11226007)	Bussel J.B.	2000	THPO, GP1BA
34	Clopidogrel-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in a kidney/pancreas transplant recipient. (10949205)	Chinnakotla S.... Tarantolo S.	2000	CABIN1
35	Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schonlein purpura. (10070906)	Floege J.... von Wussow P.	1999	MX1
36	Successful treatment of adult-onset Henoch-SchAPnlein purpura nephritis with high-dose immunoglobulins. (10361914)	Kusuda A.... Eguchi K.	1999	CD79A
37	Idiopathic thrombocytopenic purpura associated with Crohn's disease. (9542329)	Baudard M.... Zittoun R.	1998	APOH
38	Differences in tumor necrosis factor-alpha soluble receptor serum concentrations between patients with Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus: pathogenetic implications. (9489835)	Gattorno M.... Pistoia V.	1998	TNF, TNFRSF1A
39	Properties of circulating IgA molecules in Henoch-SchAPnlein purpura nephritis with focus on neutrophil cytoplasmic antigen IgA binding (IgA-ANCA): new insight into a debated issue. Italian Group of Renal Immunopathology Collaborative Study on Henoch-SchAPnlein purpura in adults and in children. (9394310)	Coppo R.... Rollino C.	1997	CD79A
40	Characteristic generated alterations of autoantibody patterns in idiopathic thrombocytopenic purpura. (9185881)	Sundblad A.... Coutinho A.	1997	SEPSECS
41	Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation. (9351524)	Hiyoyama K.... Kato T.	1997	THPO
42	Purpura fulminans induced by disseminated intravascul ar coagulation following infection in 2 unrelated children with double heterozy gosity for factor V Leiden and protein S deficiency. (9241737)	Inbal A.... Seligsohn U.	1997	F5
43	Recombinant human interferon alpha-2b (rh IFN alpha-2b) therapy for steroid resistant idiopathic thrombocytopenic purpura (ITP). (8571936)	Fujimura K.... Kuramoto A.	1996	IFNA2
44	Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. (8865522)	Ichikawa N.... Kitano K.	1996	THPO, MPL
45	Significance of cytokines and CD68-positive microparticles in immune thrombocytopenic purpura. (7615050)	Nomura S.... Fukuhara S.	1995	CSF2
46	von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura. (8580019)	De Mattia D.... Schettini F.	1995	VWF, CD79A
47	Decreased plasma tissue factor pathway inhibitor levels in patients with thrombotic thrombocytopenic purpura. (7740478)	Kobayashi M.... Shiku H.	1995	F3
48	A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans. (7841324)	Witt I.... Schenck W.	1994	PROC
49	Inhibition of platelet GPIIb/IIIa binding to fibrinogen by serum factors: studies of circulating immune complexes and platelet antibodies in patients with hemophilia, immune thrombocytopenic purpura, human immunodeficiency virus-related immune thrombocytopenic purpura, and systemic lupus erythematosus. (2002277)	Kamiyama M.... Shido K.	1991	SRF
50	Circulating thrombomodulin in thrombotic thrombocytopenic purpura. (1659186)	Takahashi H.... Shibata A.	1991	THBD

Genes related to purpura according to GeneCards:

(show top 50)    (show all 237)

id	Symbol	Description	Score	GeneCards Section Context
1	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.1	Publications, Summaries
2	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.1	Publications, Summaries
3	THPO	thrombopoietin	11.0	Publications
4	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
5	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Functions, Publications
6	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
7	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
8	VWF	von Willebrand factor	11.0	Publications
9	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	Publications
10	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
11	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
12	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
13	FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	11.0	Publications
14	IL11	interleukin 11	11.0	Publications
15	PROCR	protein C receptor, endothelial	11.0
16	CABIN1	calcineurin binding protein 1	11.0	Publications
17	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
18	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
19	THBD	thrombomodulin	11.0	Publications
20	THBS1	thrombospondin 1	11.0	Publications
21	HP	haptoglobin	11.0	Publications
22	CFH	complement factor H	11.0	Publications
23	CD40LG	CD40 ligand	11.0	Publications
24	IFNA2	interferon, alpha 2	11.0	Publications
25	PLAT	plasminogen activator, tissue	11.0	Publications
26	ADAMTSL1	ADAMTS-like 1	11.0	Publications
27	F2	coagulation factor II (thrombin)	11.0	Publications
28	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
29	F8	coagulation factor VIII, procoagulant component	11.0	Publications
30	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
31	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
32	PSMG4	proteasome (prosome, macropain) assembly chaperone 4	11.0
33	TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	11.0
34	PSMG3	proteasome (prosome, macropain) assembly chaperone 3	11.0
35	PPIC	peptidylprolyl isomerase C (cyclophilin C)	11.0	Publications
36	GPR182	G protein-coupled receptor 182	11.0
37	GP1BB	glycoprotein Ib (platelet), beta polypeptide	11.0	Publications
38	TSR1	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	11.0
39	FOXG1	forkhead box G1	11.0
40	LTC4S	leukotriene C4 synthase	11.0	Publications
41	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	11.0	Publications
42	C1S	complement component 1, s subcomponent	11.0	Publications
43	MEFV	Mediterranean fever	11.0	Publications
44	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	11.0	Publications
45	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
46	CTSL1	cathepsin L1	11.0	Publications
47	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
48	POU2F3	POU class 2 homeobox 3	11.0
49	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
50	GATA3	GATA binding protein 3	11.0	Publications

Pathways related to purpura according to GeneDecks:

(show top 50)    (show all 120)

id	Pathway	Score	Top Affiliating Genes
1	Phagosome20	11.3	MPO, CD36, ITGA2, ITGB2, ITGB3, FCGR1A
2	Staphylococcus aureus infection20	10.9	SELP, CFB, CFH, CFI, ITGB2, FCGR1A
3	RAR-Gamma-RXR-Alpha Degradation36	10.8	BMP4, CD80, IL11, IL12A, IL2, IL23A
4	Graft-versus-host disease20	10.6	CD86, CD80, IL1A, IL2, FASLG, HLA-A
5	Regulation of eIF4 and p70S6K36	10.6	BMP4, CD80, ITGA2, ITGA2B, ITGB2, ITGB3
6	Jak-STAT signaling pathway20	10.5	LEP, MPL, IL10, IL11, IL12A, IL12B
7	Intestinal immune network for IgA production20	10.3	CD86, CD40LG, CD80, CD40, IL10, IL2
8	Autoimmune thyroid disease20	10.2	CD86, CD40LG, CD80, CD40, IL10, IL2
9	Measles20	10.2	MX1, CD46, FCGR2B, IL12A, IL12B, IL13
10	Molecular Mechanisms of Cancer36	9.9	BMP4, BMP6, CFLAR, CD80, ITGA2, ITGA2B
11	Hematopoietic cell lineage20	9.9	MS4A1, CD36, CD5, CD9, ITGA2, ITGA2B
12	Systemic lupus erythematosus20	9.8	CD86, CD40LG, CD80, CD40, FCGR1A, FCGR2A
13	PGC1Alpha Pathway36	9.8	BMP4, BMP6, CD80, IL11, IL12A, IL12B
14	IL-6 Pathway36	9.5	BMP4, BMP6, CD80, IL10, IL11, IL12A
15	THC Differentiation Pathway36	9.5	CD86, IL10, IL12A, IL12B, IL18, IL2
16	Asthma20	9.4	CD40LG, CD40, IL10, IL13, IL4, IL5
17	Th1 Differentiation37	9.4	CD86, CD80, IL10, IL12A, IL12B, IL18
18	Endothelin-1 Signaling Pathway36	9.4	BMP4, BMP6, CD80, FGFR2, IL10, IL11
19	ERK Signaling36	9.3	BMP4, BMP6, CD80, ITGA2B, ITGB2, FGFR2
20	Type I diabetes mellitus20	9.2	CD86, CD80, IL12A, IL12B, IL1A, IL1B
21	African trypanosomiasis20	9.2	SELE, VCAM1, IL10, IL12A, IL12B, IL18
22	Leishmaniasis20	9.1	ITGB2, FCGR1A, FCGR2A, FCGR2C, FCGR3A, IL10
23	Tuberculosis20	9.1	ITGB2, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A
24	Allograft rejection20	9.0	CD86, CD40LG, CD80, CD40, IL10, IL12A
25	Influenza A20	8.9	MX1, IL12A, IL12B, IL18, IL1A, IL1B
26	SOCS Pathway36	8.9	BMP4, BMP6, CD80, FGF2, IL10, IL11
27	Malaria20	8.9	SELE, SELP, VCAM1, CD36, CD40LG, CD40
28	Pertussis20	8.8	ITGB2, IL10, IL12A, IL12B, IL1A, IL1B
29	Rheumatoid arthritis20	8.7	VEGFA, CD86, CD80, ITGB2, IL11, IL17A
30	Glucocorticoid Receptor Signaling36	8.7	BMP4, BMP6, CD80, IL10, IL11, IL12A
31	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	FOXP3, IL10, IL12A, IL2, IL2RA, IL2RB
32	Akt Signaling36	8.6	BMP4, CD80, ITGA2, ITGA2B, ITGB2, MET
33	Cytokine Network36	8.5	IL10, IL12A, IL12B, IL13, IL18, IL1A
34	Rho Family GTPases36	8.4	BMP4, BMP6, CD80, ITGA2, ITGA2B, ITGB2
35	all-trans-Retinoic Acid Signaling in Brain36	8.4	BMP4, BMP6, CD80, IL10, IL11, IL12A
36	PEDF Induced Signaling36	8.3	BMP4, BMP6, CFLAR, CD80, IL10, IL11
37	Tec Kinases Signaling36	8.2	BMP4, BMP6, CD80, ITGA2, ITGA2B, ITGB2
38	MIF Mediated Glucocorticoid Regulation36	8.2	BMP4, BMP6, CD80, IL10, IL11, IL12A
39	MIF Regulation of Innate Immune Cells36	8.2	BMP4, BMP6, CD80, IL10, IL11, IL12A
40	TGF-Beta Pathway36	8.0	BMP4, BMP6, CD80, FGF2, FGFR2, MET
41	JAK-STAT Pathway36	8.0	BMP4, BMP6, MPL, CD80, FGF2, FGFR2
42	STAT3 Pathway36	8.0	BMP4, BMP6, CD80, MET, IL10, IL11
43	Cytokine-cytokine receptor interaction20	8.0	VEGFA, LEP, MPL, CD40LG, CD40, MET
44	Chagas disease (American trypanosomiasis)20	7.9	SERPINE1, CFLAR, IL10, IL12A, IL12B, IL1B
45	NF-KappaB Family Pathway36	7.9	BMP4, BMP6, FGF2, FGFR2, MET, IL1A
46	PAK Pathway36	7.2	BMP4, BMP6, CD80, FGF2, FGFR2, MET
47	MAPK Family Pathway36	7.2	BMP4, BMP6, CD80, FGF2, FGFR2, MET
48	Antioxidant Action of Vitamin-C36	7.0	BMP4, BMP6, CD80, FGF2, FGFR2, MET
49	Blood Coagulation Signaling Pathways37	INF	VWF, SERPINC1, SERPINF2, SERPINE1, GP1BA, GP6
50	Complement and coagulation cascades20	INF	VWF, SERPINC1, SERPINF2, SERPINE1, CFB, CFH

Compounds related to purpura according to GeneDecks:

(show top 50)    (show all 470)

id	Compound	Score	Top Affiliating Genes
1	alemtuzumab32 9 9	13.5	CD40LG, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A
2	phosphatidylserine32 9 9	13.4	RECK, VWF, SELE, CD79A, MBL2, GP1BA
3	methionine32	11.3	RECK, VWF, CFI, ITGA2, MEFV, FCGRT
4	ptca32	11.2	SELP, SERPINF2, ITGB2, APOH, F3, PPIC
5	basiliximab32 9 9	13.0	FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, IL2
6	silicone32	10.9	SELE, SERPINC1, CD79A, CD36, CD40LG, ITGB2
7	polyethylene glycol32	10.8	SELE, SERPINC1, MPL, MPO, CD9, APOA1
8	mycophenolate mofetil32 9 9	12.8	SELE, SELP, SEPSECS, SERPINE1, CD79A, CD36
9	polyacrylamide32	10.8	RECK, S100A8, CFB, CFI, ITGA2, ITGB2
10	sp 60012532 42	11.7	VCAM1, CD40, IL13, IL17A, TLR2
11	agarose32	10.7	VWF, CFB, IL1RN, APOH, FASLG, FAS
12	hyaluronic acid32 18	11.6	BMP6, SCGB1A1, CFH, CD36, ITGB2, FGF2
13	ivig32	10.5	VWF, SEPSECS, FCGR1A, FCGR2B, FCGR3A, FCGRT
14	carboplatin32 34 9 9	13.4	VEGFA, MTHFR, IL11, IL1A, FASLG, IFNA2
15	clopidogrel32 34 9 18 9	14.3	SERPINC1, CD40LG, CD40, F10, HMGCR, PPBP
16	atp32	10.3	RECK, MX1, CD9, ITGA2, ITGB2, ITGB3
17	cysteine32	10.2	RECK, SELP, BMP4, MTHFR, S100A8, CFH
18	p00332	10.2	SERPINE1, LEP, FOXP3, IL13, IL1R1, IL1RN
19	epinephrine32 9 18 9	13.1	SELE, SELP, SERPINF2, BMP6, LEP, CD79A
20	etoposide32 42 9 9	13.1	RECK, SELE, CFLAR, FASLG, FAS, IFNA2
21	h2o232	10.0	VWF, LEP, MPO, CD79A, CD40, ITGB2
22	phosphatidylcholine32	9.9	SELE, VCAM1, CD79A, ITGA2, FGF2, IL1A
23	5-aza-2deoxycytidine32	9.9	BMP6, CFLAR, FGFR2, FASLG, FAS, MBD4
24	isoproterenol32 9 9	11.9	FGF2, IL13, IL1A, IL5, IGHE, SRF
25	methacholine32 9 9	11.6	MPO, CD79A, MME, IL13, IL17A, IL2RB
26	sodium nitroprusside32	9.6	VWF, BMP6, CD40, MME, IL12B, IL13
27	suramin32 9 9	11.6	RECK, VEGFA, BMP6, CFI, CD79A, FGF2
28	polyinosinic-polycytidylic acid32	9.4	SELE, VCAM1, CD40, IL10, IL12B, IL18
29	bleomycin32 9 9	11.2	FGF2, IL13, IL2RA, IL4, IL5, CCL2
30	uric acid32 18	10.1	SERPINE1, LEP, MTHFR, CD9, IL1R1, APOA1
31	fmlp32	9.1	SELP, VCAM1, MPO, ITGB2, MME, FCGR1A
32	adalimumab32 9 9	10.9	CD79A, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A
33	peptidoglycan32	8.8	IL10, IL12B, IL1B, IL1R1, IL1RN, IL8
34	arsenite32 18	9.8	VEGFA, CFLAR, MMP9, FASLG, FAS, IFNA1
35	fluticasone propionate32 42 9 9	11.7	SELE, VCAM1, MPO, MMP9, IL13, IL1B
36	vitamin a32 9 18 9	11.6	VWF, SCGB1A1, LEP, MME, FAS, IGHE
37	poly(i-c)32	8.6	VCAM1, MX1, IL12B, IL18, IL1B, IL4
38	alanine32	8.5	VWF, SELE, SERPINC1, SERPINF2, VCAM1, BMP6
39	leukotriene b432 42 18	10.5	SELP, MPO, ITGB2, MMP9, IL11, IL13
40	tgf beta132	8.2	SERPINE1, VCAM1, BMP4, BMP6, CD36, MMP9
41	atorvastatin32 34 9 18 9	11.5	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
42	il 1032	7.5	BMP6, CD40, IL10, IL12B, IL13, IL18
43	simvastatin32 34 42 9 18 9	12.4	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
44	pdtc32	7.4	SELE, VCAM1, CFLAR, CD40, MMP9, MET
45	hydrocortisone32 9 9	9.3	BMP6, CD36, CD40, FGF2, IL10, IL13
46	thymidine32 18	8.2	BMP4, BMP6, MTHFR, CFLAR, CD72, CD40
47	superoxide32 18	8.2	VCAM1, S100A8, MPO, CD40, ITGB2, MME
48	pd 98,05932	6.2	RECK, SERPINE1, VCAM1, BMP4, BMP6, LEP
49	prostacyclin32	INF	VWF, SELE, SELP, SERPINC1, SERPINE1, VEGFA
50	cholesterol32 9 18 9	INF	RECK, VWF, SELE, SELP, SERPINF2, SERPINE1

Cellular components related to purpura according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	clathrin-coated endocytic vesicle membrane	GO:030669	10.6	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, FCGR1A
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
3	ER to Golgi transport vesicle membrane	GO:012507	10.3	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
4	integral to plasma membrane	GO:005887	10.3	SELP, MS4A1, MPL, JAG1, CD36, IL1R1
5	external side of plasma membrane	GO:009897	9.7	VCAM1, IL2RB, IL4, FASLG, FAS, IFNG
6	cell surface	GO:009986	9.2	ABCB1, NOTCH2, PLAT, TNFSF4, TLR2, THBD
7	plasma membrane	GO:005886	7.9	F5, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3
8	extracellular space	GO:005615	5.8	EPO, HGF, CCL11, HSPG2, HP, HMOX1
9	extracellular region	GO:005576	INF	F10, PLAT, NOTCH1, NOTCH2, NOTCH3, PF4
10	platelet alpha granule lumen	GO:031093	INF	IGF1, F8, F5, ALB, F13A1, PPBP

Biological processes related to purpura according to GeneDecks:

(show top 50)    (show all 54)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:007155	11.5	F8, GP1BB, GP1BA, CCL11, AMELX, F5
2	interferon-gamma-mediated signaling pathway	GO:060333	11.2	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DPB1
3	blood coagulation, intrinsic pathway	GO:007597	11.1	F11, F10, F2, F8, F9, GP1BB
4	complement activation	GO:006956	11.0	C4B, C4A, C2, C1R, C1S, IGKC
5	negative regulation of fibrinolysis	GO:051918	10.9	THBD, F2, APOH, SERPINE1, SERPINF2, THBS1
6	complement activation, classical pathway	GO:006958	10.9	C1R, C2, C4A, C4B, C4BPA, C1S
7	positive regulation of interleukin-12 production	GO:032735	10.8	TLR4, TLR2, TNFSF4, IFNG, IL23A, IL12B
8	T cell costimulation	GO:031295	10.8	CTLA4, TNFRSF13C, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
9	T-helper 1 type immune response	GO:042088	10.8	TLR4, HLA-DRB4, HLA-DRB3, HLA-DRB1, IL18BP, IL18
10	positive regulation of tumor necrosis factor production	GO:032760	10.7	IL12B, CD36, IL18, IL23A, IFNG, TNFRSF1A
11	cell surface receptor signaling pathway	GO:007166	10.6	IFNB1, IFNG, F2, CABIN1, TNFRSF13B, EDN1
12	cytokine-mediated signaling pathway	GO:019221	10.6	CSF3, VCAM1, MX1, FCGR1A, IL13RA2, IL1A
13	positive regulation of T cell proliferation	GO:042102	10.6	IL6, IFNG, TNFRSF13C, HES1, IL4, IL23A
14	positive regulation of inflammatory response	GO:050729	10.6	AGT, AGTR1, TLR2, TLR4, TLR7, TNFSF4
15	positive regulation of B cell proliferation	GO:030890	10.6	CD40LG, CD40, IL13, IL2, IL4, IL5
16	negative regulation of interferon-gamma production	GO:032689	10.5	GATA3, TLR4, TNFSF4, HLA-DRB4, HLA-DRB3, HLA-DRB1
17	negative regulation of interleukin-17 production	GO:032700	10.4	TLR4, TLR2, TNFSF4, IFNG, IL12B, IL12A
18	immune response	GO:006955	10.3	THBS1, PROCR, CSF2, CSF3, TLR4, BMP6
19	defense response to Gram-negative bacterium	GO:050829	10.2	SELP, SERPINE1, IL12B, IL23A, IL6, NOS2
20	cellular response to mechanical stimulus	GO:071260	10.1	TNFRSF1A, AGT, TLR4, TLR7, CASP1, FAS
21	response to lipopolysaccharide	GO:032496	10.0	SELE, TNFRSF1A, NOTCH1, LTA, EDN1, TLR4
22	positive regulation of angiogenesis	GO:045766	10.0	HMOX1, TNFRSF1A, NOS3, THBS1, ADM, F3
23	cellular response to lipopolysaccharide	GO:071222	9.9	ICAM1, TNFSF4, NOS2, LTC4S, TLR4, IFNG
24	positive regulation of interferon-gamma production	GO:032729	9.9	TLR4, LTA, TNFSF4, TNF, IL23A, IL2
25	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	EPO, CSF2, IGF1, IL4, IL23A, IL2
26	positive regulation of activated T cell proliferation	GO:042104	9.9	IL12B, IL18, IL2, IL23A, IL4, IGF1
27	cell-cell signaling	GO:007267	9.9	CCL17, IFNA2, TNFSF10, DLL1, PHEX, LTA
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	HGF, TLR4, AGT, IGF1, IL6, IL5
29	negative regulation of growth of symbiont in host	GO:044130	9.6	TLR2, LTA, TNF, IFNG, MBL2, IL12B
30	response to ethanol	GO:045471	9.5	GATA3, SOD1, PRF1, TLR4, NOS3, TNFRSF1A
31	positive regulation of interleukin-6 production	GO:032755	9.4	TLR7, TLR4, TLR2, TNFSF4, TNF, IL6
32	positive regulation of NF-kappaB import into nucleus	GO:042346	9.4	TLR4, TLR7, TLR2, TNF, IL23A, IL12B
33	induction of apoptosis	GO:006917	9.1	NOTCH2, LTA, AGT, TLR2, THBS1, TGFB1
34	positive regulation of cell proliferation	GO:008284	9.0	FGFR2, IL11, IL2, IL6, ILK, FASLG
35	lipopolysaccharide-mediated signaling pathway	GO:031663	8.7	TGFB1, TLR4, TLR2, NOS3, TNF, CCL2
36	positive regulation of smooth muscle cell proliferation	GO:048661	8.4	EDN1, NOTCH3, TNF, HMOX1, IGF1, IL6
37	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	TLR4, TLR2, EDN1, TNF, ESR1, HSP90AA1
38	response to glucocorticoid stimulus	GO:051384	8.2	ADM, OXT, PLAT, TNF, CCL2, FAS
39	inflammatory response	GO:006954	8.1	BMP6, IL23A, IL5, IL6, IL8, CCL2
40	signal transduction	GO:007165	8.0	TNFSF4, TNFSF13B, TNFSF13, TNFSF10, TNFRSF17, HLA-DRB4
41	anti-apoptosis	GO:006916	7.9	F3, HMOX1, TNF, NOS3, NOTCH2, THBS1
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	JAG1, CD40, FOXP3, FGF2, FGFR2, IL11
43	response to drug	GO:042493	7.6	NOS3, LTA, LTC4S, EDN1, ABCB1, THBS1
44	response to hypoxia	GO:001666	7.5	VEGFA, VCAM1, LEP, MMP9, IL18, IL1A
45	platelet activation	GO:030168	INF	IL11, SRF, PPBP, PF4, THBS1, THPO
46	proteolysis	GO:006508	INF	PHEX, C1S, C1R, C2, ACE,
47	regulation of complement activation	GO:030449	INF	, C4BPA, C4B, C4A, C2, CD46
48	blood coagulation	GO:007596	INF	CD9, ITGA2, ITGA2B, ITGB2, ITGB3, APOA1
49	innate immune response	GO:045087	INF	C4BPA, TLR2, TLR4, TLR7, , CSF1
50	platelet degranulation	GO:002576	INF	VWF, F5, ALB, F13A1, PPBP, PF4

Molecular functions related to purpura according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:004888	10.9	GP1BB, GP6, ICAM1, TLR2, TLR4, THBD
2	serine-type endopeptidase activity	GO:004252	10.7	C1S, C2, PRSS1, PRTN3, PROC, HGF
3	IgG binding	GO:019864	10.6	FCGRT, FCGR3A, FCGR2C, FCGR2B, FCGR2A, FCGR1A
4	receptor activity	GO:004872	10.5	TNFRSF13B, TNFRSF17, NOTCH1, NOTCH2, TLR2, TLR4
5	heparin binding	GO:008201	10.2	APOH, CCL2, F11, PF4, FGFR2, FGF2
6	receptor binding	GO:005102	9.9	HLA-B, TNFSF10, TNFSF13, TNFSF13B, TNFSF4, NOS2
7	tumor necrosis factor receptor binding	GO:005164	9.8	LTA, TNFSF4, TNFSF13B, TNFSF13, TNFSF10, TNF
8	growth factor activity	GO:008083	8.5	HGF, IL4, IL2, IL1B, IL12B, IL12A
9	cytokine activity	GO:005125	8.3	IL1B, VEGFA, BMP4, BMP6, CD40LG, IL1A
10	protein homodimerization activity	GO:042803	7.8	NR0B2, CRP, NOS2, G6PD, HES1, TGFB1
11	protein binding	GO:005515	5.8	GGT1, GATA3, EPO, HGF, ADM, ADAMTS13