Aliases & Classifications for Purpura

Summaries for Purpura

MalaCards based summary : Purpura, also known as purpuric disorder, is related to hyperglobulinemic purpura and thrombotic thrombocytopenic purpura, and has symptoms including integumentary system signs and symptoms, petechiae of skin and skin manifestations. An important gene associated with Purpura is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs Dexamethasone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying... more...

Related Diseases for Purpura

Diseases related to Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 808)
# Related Disease Score Top Affiliating Genes
1 hyperglobulinemic purpura 33.8 CD40LG CD79A
2 thrombotic thrombocytopenic purpura 33.6 ADAMTS13 APOH F3 THBD VWF
3 thrombocytopenic purpura, autoimmune 33.2 GP1BA ITGA2B ITGB3 MPL THPO
4 purpura fulminans 32.8 F2 F3 PROC PROCR PROS1 SERPINC1
5 amegakaryocytic thrombocytopenia, congenital 32.7 MPL THPO
6 thrombocytopenia due to platelet alloimmunization 32.4 CD40LG ITGA2B MPL THPO
7 hypersensitivity vasculitis 32.0 CD40LG CD79A CRP
8 fetal and neonatal alloimmune thrombocytopenia 31.5 GP1BA ITGA2B ITGB3
9 hemolytic-uremic syndrome 30.9 ADAMTS13 THBD VWF
10 heparin-induced thrombocytopenia 30.6 CD40LG F3 SERPINC1
11 pseudo-von willebrand disease 30.6 GP1BA VWF
12 prothrombin deficiency, congenital 30.4 APOH F2 SERPINC1
13 cryofibrinogenemia 30.3 CD40LG CD79A
14 mixed connective tissue disease 30.3 ADAMTS13 CD40LG TNF
15 disseminated intravascular coagulation 30.3 ADAMTS13 F2 F3 SERPINC1 THBD
16 von willebrand disease, type 3 30.3 GP1BA VWF
17 protein c deficiency 30.3 F2 PROC SERPINC1 THBD
18 von willebrand's disease 30.2 ADAMTS13 F2 F3 GP1BA VWF
19 subacute bacterial endocarditis 30.2 CD40LG CD79A
20 catastrophic antiphospholipid syndrome 30.1 ADAMTS13 APOH CD40LG F3 PROC
21 acquired von willebrand syndrome 30.1 GP1BA VWF
22 connective tissue disease 30.0 ADAMTS13 APOH CD40LG TNF
23 von willebrand disease, type 1 30.0 F2 F3 VWF
24 qualitative platelet defect 30.0 F2 F3 VWF
25 autosomal dominant macrothrombocytopenia 30.0 GP1BA ITGA2B ITGB3
26 bleeding disorder, platelet-type, 16 29.9 ITGA2B ITGB3
27 meningococcemia 29.9 PROC PROCR SERPINC1 THBD
28 churg-strauss syndrome 29.9 CD40LG THBD TNF
29 factor xi deficiency 29.8 F2 F3 SERPINC1
30 bernard-soulier syndrome 29.8 F2 GP1BA ITGA2B ITGB3 THPO VWF
31 hemophilia b 29.7 F2 F3 SERPINC1
32 hemophilia 29.7 F2 F3 VWF
33 central retinal vein occlusion 29.7 APOH F2 SERPINC1
34 portal vein thrombosis 29.7 APOH F2 SERPINC1
35 antithrombin iii deficiency 29.7 APOH F2 SERPINC1
36 retinal vein occlusion 29.7 APOH F2 SERPINC1
37 factor xii deficiency 29.7 APOH F3 SERPINC1
38 severe hemophilia a 29.6 F2 F3 TNF
39 intussusception 29.6 CD40LG CD79A CRP
40 monoclonal gammopathy of uncertain significance 29.6 CD40LG CD79A TNF
41 pneumocystosis 29.6 CD40LG CD79A TNF
42 meningitis 29.6 CD40LG CRP TNF
43 hypersplenism 29.6 F2 SERPINC1 THPO
44 afibrinogenemia, congenital 29.6 F2 F3 SERPINC1 VWF
45 brucellosis 29.6 CD40LG CRP TNF
46 guillain-barre syndrome 29.5 CD40LG CD79A TNF
47 syphilis 29.5 APOH CD40LG CD79A
48 viral hepatitis 29.5 CD40LG F2 TNF
49 erythema infectiosum 29.5 APOH CD40LG
50 thrombophlebitis 29.5 APOH F2 SERPINC1

Graphical network of the top 20 diseases related to Purpura:



Diseases related to Purpura

Symptoms & Phenotypes for Purpura

UMLS symptoms related to Purpura:


integumentary system signs and symptoms, petechiae of skin, skin manifestations, pruritus, icterus, hemoptysis, flushing

MGI Mouse Phenotypes related to Purpura:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 PROCR THPO TNF PROS1 VWF SERPINC1
2 homeostasis/metabolism MP:0005376 10.3 PROCR THPO TNF PROS1 VWF SERPINC1
3 cardiovascular system MP:0005385 10.25 PROCR TNF PROS1 VWF SERPINC1 THBD
4 immune system MP:0005387 10.16 PROCR THPO TNF VWF SERPINC1 THBD
5 embryo MP:0005380 10.1 PROCR TNF PROS1 SERPINC1 THBD F3
6 mortality/aging MP:0010768 9.8 THBD PROCR TNF PROS1 VWF SERPINC1
7 liver/biliary system MP:0005370 9.7 PROC THBD TNF PROS1 SERPINC1 CD79A
8 nervous system MP:0003631 9.36 PROC THBD TNF PROS1 VWF SERPINC1

Drugs & Therapeutics for Purpura

Drugs for Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 243)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 53-03-2 5865
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
4
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
5
Dexlansoprazole Approved, Investigational Phase 4,Phase 2 138530-94-6, 103577-45-3 9578005
6
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
9
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
11
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3 104987-11-3 445643 439492
12
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
13
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
14
Hydroxychloroquine Approved Phase 4 118-42-3 3652
15
Vincristine Approved, Investigational Phase 4,Phase 2,Phase 3 2068-78-2, 57-22-7 5978
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 68-26-8, 11103-57-4 445354
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
19
Caffeic acid Experimental, Investigational Phase 4,Phase 3 331-39-5 1549111
20 Antiemetics Phase 4,Phase 3,Phase 2
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
22 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
23 Antioxidants Phase 4,Phase 2,Phase 3,Early Phase 1
24 Autonomic Agents Phase 4,Phase 3,Phase 2
25 BB 1101 Phase 4,Phase 3,Phase 2
26 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
28 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
29 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
31 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
34
protease inhibitors Phase 4,Phase 3,Phase 2
35 Protective Agents Phase 4,Phase 2,Phase 3,Early Phase 1
36 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
39 gamma-Globulins Phase 4,Phase 2,Phase 3
40 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
41 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 3
42 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 3
43 Antacids Phase 4
44 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Anti-Ulcer Agents Phase 4
47 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
48 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
49 Neuroprotective Agents Phase 4,Phase 3,Phase 2
50 Prednisolone acetate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 333)

# Name Status NCT ID Phase Drugs
1 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
2 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
3 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
4 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
5 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
6 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
7 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
8 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
9 Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands Completed NCT01910831 Phase 4 DerMend Moisturizing Bruise Formula
10 The Study of Different Dose Rituximab in the Treatment of ITP Completed NCT03258866 Phase 4 Rituximab;Rituximab
11 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
12 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
13 The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia Recruiting NCT03201848 Phase 4 Placebo;Huaiqihuang Granule
14 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4 romiplostim
15 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
16 A Rollover Study to Provide Continued Treatment With Eltrombopag Active, not recruiting NCT01957176 Phase 4 ELT
17 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
18 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Not yet recruiting NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
19 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
20 Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura Withdrawn NCT01754545 Phase 4 Octaplas infusion and placebo (group 1);Octaplas infusion and placebo (group 2)
21 Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP) Withdrawn NCT02642380 Phase 4 Dexamethasone (4 cycles);Dexamethasone (1 cycle)
22 The Efficacy of Dexamethasone Versus Dexamethasone Combined With Rituximab in Patients With Newly Diagnosed Idiopathic Thrombocytopenic Purpura (ITP) Unknown status NCT00909077 Phase 3 Dexamethasone;Dexamethasone and Rituximab
23 Efficacy and Safety Study of Maintenance Treatment With rhTPO in Thrombocytopenic Subjects With ITP Unknown status NCT01805648 Phase 3 rhTPO
24 A Multicenter Study on Recombinant Human Thrombopoietin in Management of ITP in Pregnancy Unknown status NCT02391272 Phase 3 rhTPO
25 Recombinant Human Thrombopoietin (rhTPO) in Management of Immune Thrombocytopenia (ITP) in Pregnancy Unknown status NCT02270801 Phase 3 rhTPO
26 Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia Unknown status NCT01763658 Phase 2, Phase 3 Antox tablets(Mepaco)
27 A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076399 Phase 3 Fostamatinib Disodium 100mg;Placebo;Fostamatinib Disodium 150mg
28 A Long-term Safety Study of Eltrombopag in Pediatric Patients With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT02201290 Phase 3 Eltrombopag Tablets;Eltrombopag PfOS
29 A Efficacy and Safety Study of Fostamatinib in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076412 Phase 3 Fostamatinib Disodium 100mg;Placebo;Fostamatinib Disodium 150mg
30 A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune (Idiopathic) Thrombocytopenia Purpura Completed NCT01071954 Phase 3
31 P3 Study to Evaluate Efficacy and Safety of AMG 531 in Thrombocytopenic Japanese Subjects With Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00603642 Phase 3 Placebo;AMG 531
32 Treatment of Chronic Immune Thrombocytopenic Purpura (ITP) With Intravenous Immunoglobulin IgPro10 Completed NCT00168038 Phase 3
33 Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT00713193 Phase 3 Cyclosporine;Prednisone
34 Clinical Trial in Patients Diagnosed With Immune Thrombocytopenic Purpura Completed NCT00699140 Phase 3
35 Clinical Study to Evaluate the Efficacy and Safety of Octagam 10% in Idiopathic Thrombocytopenic Purpura in Adults Completed NCT00426270 Phase 3 Octagam 10%
36 Ig NextGen 10% in Idiopathic Thrombocytopenic Purpura (ITP) Patients Completed NCT00362349 Phase 3 IgNextGen 10%
37 A Study to Find How Safe and Effective GAMMAPLEX® is in Subjects With Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00504075 Phase 3
38 Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura Completed NCT00657410 Phase 3 dexamethasone;prednisone
39 Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura Completed NCT02553317 Phase 3
40 Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00415532 Phase 3 Medical Standard of Care for ITP
41 Clinical Evaluation of Eltrombopag in Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00828750 Phase 3 Eltrombopag oral tablets
42 Open Label Extension Study of Romiplostim (AMG 531) in Thrombocytopenic Patients With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT00116688 Phase 3
43 Clinical Evaluation of SB-497115-GR in Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00540423 Phase 3 SB-497115-GR 12.5mg;SB-497115-GR 25mg;SB-497115-GR 12.5mg matching placebo;SB-497115-GR 50 mg
44 A Study Evaluating the Addition of MabThera (Rituximab) to Standard Treatment in Patients With Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00770562 Phase 3 rituximab;Dexamethasone
45 Helicobacter Pylori Treatment in Immune Thrombocytopenic Purpura (ITP) Patients Completed NCT01730352 Phase 2, Phase 3 H. pylori triple therapy
46 AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy Completed NCT00102336 Phase 3 Placebo
47 AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Refractory to Splenectomy Completed NCT00102323 Phase 3 Placebo
48 EXTEND (Eltrombopag Extended Dosing Study) Completed NCT00351468 Phase 3 eltrombopag olamine (SB-497115-GR)
49 IGIV Study for Chronic ITP Patients Ages 3-70 Completed NCT00511147 Phase 3
50 Efficacy and Safety of IVIG-L in ITP Patients Completed NCT00151840 Phase 3 IVIG-L

Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: purpura

Genetic Tests for Purpura

Genetic tests related to Purpura:

# Genetic test Affiliating Genes
1 Purpura 28

Anatomical Context for Purpura

MalaCards organs/tissues related to Purpura:

38
Skin, Bone, T Cells, Bone Marrow, Testes, Liver, Endothelial

Publications for Purpura

Articles related to Purpura:

(show top 50) (show all 2821)
# Title Authors Year
1
Genetics of immunoglobulin-A vasculitis (Henoch-SchAPnlein purpura): An updated review. ( 29353097 )
2018
2
Neuro-Behcet's disease in a patient with thrombotic thrombocytopenic purpura. ( 29444324 )
2018
3
Dynamic dosing of romiplostim in patients with immune thrombocytopenia purpura: Two case reports. ( 29357781 )
2018
4
Acute infectious purpura fulminans secondary to a dog bite. ( 29437318 )
2018
5
Case of atopic dermatitis concurrent with idiopathic thrombocytopenic purpura, whose serum thymus and activation-regulated chemokine level remained undetectable. ( 29399856 )
2018
6
Correction to: Henoch-SchAPnlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. ( 29380166 )
2018
7
Purpura fulminans - It's Not Always Sepsis. ( 29381878 )
2018
8
Wiskott-Aldrich syndrome that was initially diagnosed as immune thrombocytopenic purpura secondary to a cytomegalovirus infection. ( 29348920 )
2018
9
Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura. ( 29304523 )
2018
10
The role of T cells in the development of Henoch-Schonlein purpura. ( 28930575 )
2018
11
Sequential occurrence of Graves' disease and immune thrombocytopenic purpura as manifestations of immune reconstitution inflammatory syndrome in an HIV-infected patient. ( 29361886 )
2018
12
Changes in plasma von Willebrand factor and von Willebrand factor cleaving protease in thrombotic thrombocytopenic purpura: A case report. ( 29250148 )
2018
13
Image Gallery: Periumbilical purpura: aA dermatological clue for disseminated strongyloidiasis. ( 29441550 )
2018
14
Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report. ( 29357939 )
2018
15
Large vessel stroke as initial presentation of thrombotic thrombocytopenic purpura. ( 29437728 )
2018
16
A novel compound heterozygous mutations in protein C gene causing neonatal purpura fulminans. ( 29356699 )
2018
17
Intravenous immunoglobulin as salvage therapy for refractory thrombotic thrombocytopenic purpura. ( 29247542 )
2018
18
Odontogenic focal infection is a possible trigger of severe Henoch-SchAPnlein purpura nephritis. ( 29446581 )
2018
19
No recurrence of nivolumab-induced idiopathic thrombocytopenic purpura in a metastatic melanoma patient switched to ipilimumab. ( 29400292 )
2018
20
An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura. ( 29222940 )
2018
21
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with BehAset's Disease. ( 29313056 )
2018
22
Pathophysiology of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. ( 29356300 )
2018
23
Histologic Features of Gastrointestinal Tract Biopsies in IgA Vasculitis (Henoch-SchAPnlein Purpura). ( 29438165 )
2018
24
No major differences in outcomes between the initial and relapse episodes in patients with thrombotic thrombocytopenic purpura: The experience from the Ohio State University Registry. ( 29226481 )
2018
25
Successful kidney transplantation in a patient with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome). ( 28940540 )
2017
26
Henoch-SchAPnlein Purpura Presenting as Mononeuritis Multiplex. ( 29141284 )
2017
27
Indian Tick Typhus Presenting as Purpura Fulminans with Review on Rickettsial Infections. ( 28216718 )
2017
28
Skin biopsy polymerase chain reaction for rapid microbiological diagnosis in patients with purpura fulminans. ( 28369801 )
2017
29
Autoimmune Thrombotic Thrombocytopenic Purpura: Two Rare Cases Associated with Juvenile Idiopathic Arthritis and Multiple Sclerosis. ( 28791286 )
2017
30
Rare Presentation of Refractory Thrombotic Thrombocytopenic Purpura: Jejunal Stricture. ( 29340125 )
2017
31
Evolution of Purpura Fulminans. ( 28564574 )
2017
32
Purpura Fulminans Associated with Overwhelming Postsplenectomy Infection. ( 28090064 )
2017
33
Acute Kidney Injury, Immune Thrombocytopenic Purpura, and the Infection That Binds Them Together: Disseminated Histoplasmosis. ( 29276711 )
2017
34
Siblings with congenital thrombotic thrombocytopenic purpura. ( 28883277 )
2017
35
Gardner diamond syndrome: A psychogenic purpura. ( 29204414 )
2017
36
Does Bernard-Soulier syndrome protect against thrombotic thrombocytopenic purpura? ( 28653757 )
2017
37
Purpura Fulminans as the presenting manifestation in a patient with homozygous methylenetetrahydrofolate reductase gene mutation. ( 28612584 )
2017
38
Henoch-SchAPnlein Purpura With Muscle Involvement, Presenting as Myositis. ( 28002161 )
2017
39
Reconstruction of Near-Total Loss of the Upper and Lower Lips due to Purpura Fulminans with Local Tissue and a Dual-Skin Paddled Anterolateral Thigh Flap. ( 29062669 )
2017
40
Acquired thrombotic thrombocytopenic purpura and pregnancy: More light than shade but controversies remain. ( 28697902 )
2017
41
Rituximab prophylaxis to prevent thrombotic thrombocytopenic purpura relapse: outcome and evaluation of dosing regimens. ( 29296757 )
2017
42
Diagnosis of thrombotic thrombocytopenic purpura among patients with ADAMTS13 Activity 10%-20. ( 28815685 )
2017
43
Dengue and Thrombotic Thrombocytopenic Purpura. ( 28904490 )
2017
44
Idiopathic Thrombocytopenia Purpura Masking Hodgkin Disease: A Paraneoplastic Syndrome or Simply a Mere Association? ( 29430236 )
2017
45
[Association between CTLA-4 gene polymorphism and Henoch-SchAPnlein purpura in children]. ( 28302200 )
2017
46
Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination. ( 28558983 )
2017
47
Chikungunya Fever Presenting as Life Threatening Thrombotic Thrombocytopenic Purpura. ( 28792176 )
2017
48
A novel homozygous frameshift mutation in Exon 7 of the ADAMTS13 gene in a patient with congenital thrombotic thrombocytopenic purpura from India: a case report. ( 28833243 )
2017
49
Long-term Kidney Outcomes in Patients With Acquired Thrombotic Thrombocytopenic Purpura. ( 29270517 )
2017
50
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-SchAPnlein purpura). ( 29037908 )
2017

Variations for Purpura

Expression for Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for Purpura

Pathways related to Purpura according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 APOH F2 F3 GP1BA ITGA2B ITGB3
2
Show member pathways
12.71 CD79A F2 ITGA2B ITGB3 TNF
3
Show member pathways
12.68 F2 F3 PROC PROS1 SERPINC1 THBD
4
Show member pathways
12.1 F2 ITGB3 PROC PROCR PROS1 THBD
5
Show member pathways
12 GP1BA ITGA2B ITGB3 VWF
6 11.95 ITGA2B ITGB3 THBD TNF
7 11.93 CD79A GP1BA ITGA2B ITGB3 MPL THPO
8 11.9 F2 F3 PROC PROCR PROS1 SERPINC1
9 11.89 GP1BA ITGA2B ITGB3 VWF
10 11.79 GP1BA ITGA2B ITGB3 THPO TNF
11
Show member pathways
11.79 F2 GP1BA ITGA2B ITGB3 MPL THPO
12 11.68 F3 ITGB3 VWF
13
Show member pathways
11.48 F2 F3 GP1BA PROC PROCR PROS1
14 11.44 F2 ITGA2B ITGB3 VWF
15 10.88 CD40LG ITGA2B ITGB3 THPO TNF
16 10.81 F2 PROC PROS1
17 10.68 GP1BA VWF
18 10.54 GP1BA VWF

GO Terms for Purpura

Cellular components related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ADAMTS13 APOH CD40LG CRP F2 F3
2 integral component of plasma membrane GO:0005887 9.91 CD40LG CD79A GP1BA ITGA2B ITGB3 MPL
3 blood microparticle GO:0072562 9.73 F2 ITGA2B PROS1 SERPINC1
4 extracellular space GO:0005615 9.73 ADAMTS13 APOH CD40LG CRP F2 F3
5 external side of plasma membrane GO:0009897 9.72 CD40LG CD79A F2 ITGA2B TNF
6 cell surface GO:0009986 9.36 ADAMTS13 APOH CD40LG F3 GP1BA ITGA2B
7 plasma membrane GO:0005886 10.22 CD40LG CD79A F2 F3 GP1BA ITGA2B
8 extracellular exosome GO:0070062 10.11 APOH CRP F2 F3 GP1BA ITGA2B

Biological processes related to Purpura according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.9 CD79A F2 GP1BA MPL
2 extracellular matrix organization GO:0030198 9.88 ITGA2B ITGB3 TNF VWF
3 positive regulation of protein phosphorylation GO:0001934 9.86 F2 ITGB3 THPO TNF
4 platelet degranulation GO:0002576 9.83 APOH ITGA2B ITGB3 PROS1 VWF
5 cell-matrix adhesion GO:0007160 9.79 ADAMTS13 ITGA2B ITGB3
6 integrin-mediated signaling pathway GO:0007229 9.78 ADAMTS13 ITGA2B ITGB3
7 platelet activation GO:0030168 9.73 ADAMTS13 CD40LG F2 GP1BA ITGB3 VWF
8 regulation of blood coagulation GO:0030193 9.71 APOH F2 GP1BA SERPINC1
9 fibrinolysis GO:0042730 9.7 F2 GP1BA PROS1
10 leukocyte migration GO:0050900 9.7 F2 ITGB3 PROC PROCR PROS1 THBD
11 blood coagulation GO:0007596 9.7 ADAMTS13 F2 F3 GP1BA ITGB3 PROC
12 signal peptide processing GO:0006465 9.69 F2 PROC PROS1
13 peptidyl-glutamic acid carboxylation GO:0017187 9.67 F2 PROC PROS1
14 blood coagulation, intrinsic pathway GO:0007597 9.67 APOH F2 GP1BA VWF
15 negative regulation of fibrinolysis GO:0051918 9.65 APOH F2 THBD
16 negative regulation of lipid storage GO:0010888 9.63 CRP ITGB3 TNF
17 negative regulation of blood coagulation GO:0030195 9.62 APOH PROC PROS1 THBD
18 positive regulation of blood coagulation GO:0030194 9.61 APOH F2
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.59 CRP ITGB3
20 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
21 negative regulation of coagulation GO:0050819 9.57 PROC PROCR
22 regulation of immunoglobulin secretion GO:0051023 9.55 CD40LG TNF
23 thrombopoietin-mediated signaling pathway GO:0038163 9.54 MPL THPO
24 hemostasis GO:0007599 9.32 ADAMTS13 F2 F3 GP1BA PROC PROCR

Molecular functions related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ADAMTS13 APOH CD40LG CD79A CRP F2
2 calcium ion binding GO:0005509 9.73 ADAMTS13 CRP F2 PROC PROS1 THBD
3 identical protein binding GO:0042802 9.7 APOH CRP ITGA2B ITGB3 SERPINC1 TNF
4 protease binding GO:0002020 9.02 F3 ITGB3 SERPINC1 TNF VWF

Sources for Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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