Aliases & Classifications for Purpura

Summaries for Purpura

MalaCards based summary : Purpura, also known as purpuric disorder, is related to hemarthrosis and hemolytic-uremic syndrome, and has symptoms including hemoptysis, icterus and pruritus. An important gene associated with Purpura is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Collagen chain trimerization. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 71 Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying... more...

Related Diseases for Purpura

Diseases related to Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 743)
id Related Disease Score Top Affiliating Genes
1 hemarthrosis 31.7 F2 F3
2 hemolytic-uremic syndrome 30.3 F2 F3 SERPINC1 TNF
3 influenza 29.9 F2 F3 SERPINC1
4 lupus erythematosus 29.8 CRP F3 ITGA2B SERPINC1 VWF
5 alpha-2-plasmin inhibitor deficiency 29.7 F2 GP1BA SERPINC1
6 rabies 29.6 CD40LG CD79A
7 fletcher factor deficiency 29.6 F2 F3 VWF
8 uveitis 29.5 CD40LG CD79A TNF
9 neuropathy 29.3 CRP THPO TNF
10 astrocytoma 29.2 CD40LG THBD TNF
11 herpes simplex 29.2 APOH THBD VWF
12 may-hegglin anomaly 29.1 APOH F2 SERPINC1
13 celiac disease 29.0 CD40LG CD79A CRP TNF
14 central retinal artery occlusion 28.9 APOH CD40LG F2 F3 SERPINC1
15 artery disease 28.8 CD40LG CD79A CRP F2 F3
16 essential thrombocythemia 28.8 F2 F3 GP1BA ITGA2B ITGB3 SERPINC1
17 adult t-cell leukemia 28.6 CRP F3 ITGA2B SERPINC1 VWF
18 sydenham chorea 28.4 CRP F2 F3 SERPINC1 THBD VWF
19 goodpasture syndrome 28.3 APOH CD40LG CD79A CRP SERPINC1 THBD
20 membranoproliferative glomerulonephritis 27.8 ADAMTS13 APOH CD40LG CD79A CRP F2
21 myocardial infarction 27.5 ADAMTS13 CRP F2 F3 GP1BA ITGA2
22 henoch-schoenlein purpura 12.4
23 thrombocytopenic purpura, autoimmune 12.4
24 purpura fulminans 12.3
25 thrombotic thrombocytopenic purpura 12.3
26 thrombotic thrombocytopenic purpura, familial 12.3
27 thrombotic thrombocytopenic purpura, acquired 12.1
28 hyperglobulinemic purpura 12.0
29 acquired purpura fulminans 11.9
30 purpura simplex 11.9
31 gardner-diamond syndrome 11.8
32 familial thrombotic thrombocytopenia purpura 11.7
33 pigmented purpuric dermatosis 11.7
34 immunoglobulin a vasculitis 11.6
35 hypersensitivity vasculitis 11.2
36 evans' syndrome 11.2
37 thrombophilia due to protein c deficiency, autosomal recessive 11.1
38 thrombocytopenia due to platelet alloimmunization 11.0
39 cryoglobulinemia 11.0
40 anca-associated vasculitis 11.0
41 thrombophilia due to protein s deficiency, autosomal recessive 10.8
42 immunodeficiency, common variable, 8, with autoimmunity 10.8
43 thrombocytopenia, congenital amegakaryocytic 10.7
44 autoinflammation, lipodystrophy, and dermatosis syndrome 10.7
45 ras-associated autoimmune leukoproliferative disorder 10.7
46 immunodeficiency due to purine nucleoside phosphorylase deficiency 10.7
47 sea-blue histiocyte disease 10.7
48 cryoglobulinemia, familial mixed 10.7
49 allergic cutaneous vasculitis 10.7
50 rheumatoid vasculitis 10.7

Graphical network of the top 20 diseases related to Purpura:



Diseases related to Purpura

Symptoms & Phenotypes for Purpura

UMLS symptoms related to Purpura:


hemoptysis, icterus, pruritus, skin manifestations, integumentary system signs and symptoms

MGI Mouse Phenotypes related to Purpura:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.19 ITGA2 ITGA2B ITGB3 MPL PROC PROCR
2 cardiovascular system MP:0005385 10.18 PROCR SERPINC1 THBD TNF VWF ITGA2B
3 homeostasis/metabolism MP:0005376 10.13 ADAMTS13 APOH CD40LG CD79A CRP F2
4 cellular MP:0005384 10.11 F3 GP1BA ITGA2 ITGA2B ITGB3 MPL
5 embryo MP:0005380 9.97 F2 F3 ITGA2B ITGB3 MPL PROCR
6 immune system MP:0005387 9.86 ADAMTS13 CD40LG CD79A CRP F2 F3
7 mortality/aging MP:0010768 9.44 ADAMTS13 APOH CD40LG F2 F3 ITGB3

Drugs & Therapeutics for Purpura

Drugs for Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 229)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
2
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
3
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 53-03-2 5865
8
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
11
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
15
Caffeic acid Experimental Phase 4,Phase 3 331-39-5 1549111
16 Antacids Phase 4
17 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 Anti-Ulcer Agents Phase 4
20
Dexlansoprazole Phase 4,Phase 2 138530-94-6, 103577-45-3 9578005
21 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
22 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
23 gamma-Globulins Phase 4,Phase 2,Phase 3
24 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
25 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 3
26 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 3
27 Antiemetics Phase 4,Phase 3,Phase 2
28 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
29 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
30 Autonomic Agents Phase 4,Phase 3,Phase 2
31 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
32 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
33 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
35 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
36 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
37 Neuroprotective Agents Phase 4,Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
39 Prednisolone acetate Phase 4,Phase 2,Phase 3
40 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
41 Prednisolone phosphate Phase 4,Phase 2,Phase 3
42 Protective Agents Phase 4,Phase 2,Phase 3,Early Phase 1
43 BB 1101 Phase 4,Phase 2,Phase 3
44 Dexamethasone 21-phosphate Phase 4,Phase 2,Phase 3
45 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
46 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 303)
id Name Status NCT ID Phase
1 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4
2 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4
3 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
4 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4
5 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
6 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4
7 Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands Completed NCT01910831 Phase 4
8 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4
9 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4
10 A Rollover Study to Provide Continued Treatment With Eltrombopag Recruiting NCT01957176 Phase 4
11 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4
12 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Recruiting NCT02556814 Phase 4
13 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4
14 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4
15 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
16 Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura Withdrawn NCT01754545 Phase 4
17 Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP) Withdrawn NCT02642380 Phase 4
18 Efficacy and Safety Study of Maintenance Treatment With rhTPO in Thrombocytopenic Subjects With ITP Unknown status NCT01805648 Phase 3
19 Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia Unknown status NCT01763658 Phase 2, Phase 3
20 A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076399 Phase 3
21 A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune (Idiopathic) Thrombocytopenia Purpura Completed NCT01071954 Phase 3
22 Treatment of Chronic Immune Thrombocytopenic Purpura (ITP) With Intravenous Immunoglobulin IgPro10 Completed NCT00168038 Phase 3
23 P3 Study to Evaluate Efficacy and Safety of AMG 531 in Thrombocytopenic Japanese Subjects With Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00603642 Phase 3
24 A Efficacy and Safety Study of Fostamatinib in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076412 Phase 3
25 Clinical Trial in Patients Diagnosed With Immune Thrombocytopenic Purpura Completed NCT00699140 Phase 3
26 Clinical Study to Evaluate the Efficacy and Safety of Octagam 10% in Idiopathic Thrombocytopenic Purpura in Adults Completed NCT00426270 Phase 3
27 Ig NextGen 10% in Idiopathic Thrombocytopenic Purpura (ITP) Patients Completed NCT00362349 Phase 3
28 A Study to Find How Safe and Effective GAMMAPLEX® is in Subjects With Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00504075 Phase 3
29 Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura Completed NCT00657410 Phase 3
30 Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00415532 Phase 3
31 Open Label Extension Study of Romiplostim (AMG 531) in Thrombocytopenic Patients With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT00116688 Phase 3
32 Clinical Evaluation of SB-497115-GR in Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00540423 Phase 3
33 Clinical Evaluation of Eltrombopag in Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00828750 Phase 3
34 A Study Evaluating the Addition of MabThera (Rituximab) to Standard Treatment in Patients With Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00770562 Phase 3
35 AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy Completed NCT00102336 Phase 3
36 AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Refractory to Splenectomy Completed NCT00102323 Phase 3
37 Helicobacter Pylori Treatment in Immune Thrombocytopenic Purpura (ITP) Patients Completed NCT01730352 Phase 2, Phase 3
38 EXTEND (Eltrombopag Extended Dosing Study) Completed NCT00351468 Phase 3
39 IGIV Study for Chronic ITP Patients Ages 3-70 Completed NCT00511147 Phase 3
40 Efficacy and Safety of IVIG-L in ITP Patients Completed NCT00151840 Phase 3
41 RAISE: Randomized Placebo-Controlled Idiopathic Thrombocytopenic Purpura (ITP) Study With Eltrombopag Completed NCT00370331 Phase 3
42 Study of a New Medication for Childhood Chronic Immune Thrombocytopenia (ITP), a Blood Disorder of Low Platelet Counts That Can Lead to Bruising Easily, Bleeding Gums, and/or Bleeding Inside the Body. Completed NCT01520909 Phase 3
43 High Dose Dexamethasone Vs. Conventional Dose Prednisolone in Adult ITP Completed NCT00451594 Phase 3
44 rhTPO Combining Rituximab Versus Low-dose Rituximab in Management of ITP Completed NCT01525836 Phase 3
45 Open Label Extension Study of AMG 531 in Japanese Subjects With ITP Completed NCT00440037 Phase 2, Phase 3
46 An Open Label Study of Romiplostim in Adult Thrombocytopenic Subjects With ITP Completed NCT00508820 Phase 3
47 Recombinant Human Thrombopoietin in Combination With Rituximab in Immune Thrombocytopenia (ITP) Completed NCT01506414 Phase 3
48 A Randomized Study of IVIG vs. IVIG With High Dose Methylprednisolone in Childhood ITP. Completed NCT00376077 Phase 3
49 Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02) Completed NCT01438840 Phase 3
50 Safety and Efficacy Study of Romiplostim to Treat Immune Thrombocytopenia (ITP) in Pediatric Patients Completed NCT01444417 Phase 3

Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: purpura

Genetic Tests for Purpura

Genetic tests related to Purpura:

id Genetic test Affiliating Genes
1 Purpura 29

Anatomical Context for Purpura

MalaCards organs/tissues related to Purpura:

39
Skin, T Cells, Endothelial, Liver, Bone, B Cells, Bone Marrow

Publications for Purpura

Articles related to Purpura:

(show top 50) (show all 2697)
id Title Authors Year
1
Linear nonpalpable purpura in a young male: a unique presentation of leukemia cutis in T-cell prolymphocytic leukemia. ( 28083939 )
2017
2
Progressive Purpura in a Long-term Care Patient. ( 28055068 )
2017
3
Henoch-SchAPnlein Purpura With Muscle Involvement, Presenting as Myositis. ( 28002161 )
2017
4
Autoimmune Hepatitis Associated with Immune Thrombocytopenic Purpura. ( 28090042 )
2017
5
Purpura Fulminans Associated with Overwhelming Postsplenectomy Infection. ( 28090064 )
2017
6
The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura. ( 27866840 )
2017
7
Aquaporin-4 positive neuromyelitis optica spectrum disorders secondary to thrombopenic purpura: A case report. ( 28079804 )
2017
8
Endothelial function in children with a history of henoch schonlein purpura. ( 28088210 )
2017
9
Henoch-SchAPnlein Purpura and Influenza Vaccine. ( 28065339 )
2017
10
Dynamic changes in absolute immature platelet count suggest the presence of a coexisting immune process in the setting of thrombotic thrombocytopenic purpura. ( 28083876 )
2017
11
Henoch-SchAPnlein purpura as a rare cause of an acute abdomen. ( 28052686 )
2017
12
A case report of iatrogenic cutaneous Kaposi sarcoma due to rituximab therapy for thrombotic thrombocytopenic purpura. ( 27885868 )
2017
13
Coexisting Situs Inversus Totalis and Immune Thrombocytopenic Purpura. ( 26981307 )
2016
14
Granulocyte colony-stimulating factor decreases the Th1/Th2 ratio in peripheral blood mononuclear cells from patients with chronic immune thrombocytopenic purpura in vitro. ( 27815970 )
2016
15
Prognostic risk-stratified score for predicting mortality in hospitalized patients with thrombotic thrombocytopenic purpura: nationally representative data from 2007 to 2012. ( 27079482 )
2016
16
High prevalence of hereditary thrombotic thrombocytopenic purpura in central Norway: from clinical observation to evidence. ( 26566785 )
2016
17
Purpura fulminans secondary to rickettsial infections: A case series. ( 26955583 )
2016
18
Isolated thrombocytopenia and liver function abnormalities characterizing an atypical presentation of thrombotic thrombocytopenic purpura. ( 27542956 )
2016
19
Successful rituximab treatment in an elderly patient with recurrent thrombotic thrombocytopenic purpura. ( 27498731 )
2016
20
Clinical features and outcomes of diffuse endocapillary proliferation Henoch-SchAPnlein purpura nephritis in children. ( 27652838 )
2016
21
CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides. ( 26747250 )
2016
22
Bortezomib in the treatment of refractory thrombotic thrombocytopenic purpura. ( 27009919 )
2016
23
Autoimmune thrombotic thrombocytopenic purpura associated with HHV8-related Multicentric Castleman disease. ( 27221364 )
2016
24
Purpura and leukopenia in a cocaine user. ( 27174436 )
2016
25
Differentiation of pernicious anemia from thrombotic thrombocytopenic purpura: The clinical value of subtle pathologic findings. ( 27765664 )
2016
26
Dermoscopic pattern in a case of suction purpura over the face. ( 27990409 )
2016
27
Two cases of thrombocytopenic purpura at onset of Zika virus infection. ( 27596376 )
2016
28
Plasma gelsolin as a potential biomarker for Henoch- Schoenlein purpura. ( 27575439 )
2016
29
Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion. ( 27032848 )
2016
30
Thrombotic Thrombocytopenic Purpura and Atypical Hemolytic Uremic Syndrome Microangiopathy in Pregnancy. ( 27648610 )
2016
31
[Association of Cosmc gene mutation with susceptibility to Henoch-SchAPnlein purpura in children]. ( 27412546 )
2016
32
Circulating midkine in children with Henoch-SchAPnlein purpura: Clinical implications. ( 27497193 )
2016
33
Acute myocardial infarction as the initial thrombotic event of thrombotic thrombocytopenic purpura. ( 26757016 )
2016
34
Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. ( 26863353 )
2016
35
Acute infectious purpura fulminans caused by group A I^-hemolytic Streptococcus: An uncommon organism. ( 27057503 )
2016
36
Purpura fulminans associated with acute West Nile virus encephalitis. ( 26686320 )
2016
37
Systemic Lupus Erythematosus Presenting as Refractory Thrombotic Thrombocytopenic Purpura: A Diagnostic and Management Challenge. A Case Report and Concise Review of the Literature. ( 27777394 )
2016
38
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy. ( 27132698 )
2016
39
Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura. ( 27501520 )
2016
40
Familial acquired thrombotic thrombocytopenic purpura in siblings - no immunogenetic link with associated human leucocyte antigens. ( 27859681 )
2016
41
Congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) caused by novel ADAMTS13 mutations. ( 26085195 )
2016
42
Purpura fulminans related to paroxysmal nocturnal haemoglobinuria. ( 27046923 )
2016
43
Terminal Ileitis as a Feature of Henoch-SchAPnlein Purpura Masquerading as Crohn Disease in Adults. ( 26906301 )
2016
44
N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura. ( 28011677 )
2016
45
A case of congenital prothrombin deficiency and idiopathic thrombocytopenic purpura in a pregnant female. ( 26886363 )
2016
46
Henoch-SchAPnlein purpura nephritis and colitis in an adult patient with alcoholic liver cirrhosis. ( 27668165 )
2016
47
Use of the automated fragmented red cell count for monitoring patients with thrombotic thrombocytopenic purpura. ( 27565612 )
2016
48
Intravenous immunoglobulins for severe gastrointestinal involvement in pediatric Henoch-SchAPnlein purpura: A French retrospective study. ( 27133370 )
2016
49
Carboxiterminal pro-endothelin-1 as an endothelial cell biomarker in thrombotic thrombocytopenic purpura. ( 26763086 )
2016
50
ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. ( 27040144 )
2016

Variations for Purpura

Expression for Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for Purpura

Pathways related to Purpura according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 CD79A F2 ITGA2 ITGA2B ITGB3 TNF
2
Show member pathways
12.7 F2 F3 PROC SERPINC1 THBD
3
Show member pathways
12.55 APOH F2 F3 GP1BA ITGA2 ITGA2B
4
Show member pathways
12.15 F2 ITGB3 PROC PROCR THBD
5
Show member pathways
12.08 ITGA2 ITGA2B ITGB3 TNF
6
Show member pathways
12.03 GP1BA ITGA2 ITGA2B ITGB3 VWF
7 12.01 F2 F3 PROC PROCR SERPINC1 THBD
8
Show member pathways
11.96 F2 F3 GP1BA PROC PROCR SERPINC1
9 11.95 ITGA2B ITGB3 THBD TNF
10 11.92 GP1BA ITGA2 ITGA2B ITGB3 VWF
11 11.83 GP1BA ITGA2 ITGA2B ITGB3 THPO TNF
12
Show member pathways
11.79 F2 GP1BA ITGA2B ITGB3 MPL THPO
13 11.69 F3 ITGB3 VWF
14 11.67 ITGA2 ITGA2B ITGB3
15 11.63 CD79A GP1BA ITGA2 ITGA2B ITGB3 MPL
16 11.51 F2 ITGA2 ITGA2B ITGB3 VWF
17 11.48 ITGA2 ITGA2B ITGB3
18 10.77 GP1BA ITGA2 VWF
19 10.56 GP1BA VWF

GO Terms for Purpura

Cellular components related to Purpura according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.97 CD40LG CD79A GP1BA ITGA2B ITGB3 MPL
2 extracellular region GO:0005576 9.93 ADAMTS13 APOH CD40LG CRP F2 F3
3 external side of plasma membrane GO:0009897 9.73 CD40LG CD79A F2 ITGA2 ITGA2B TNF
4 extracellular space GO:0005615 9.7 ADAMTS13 APOH CD40LG CRP F2 F3
5 integrin complex GO:0008305 9.54 ITGA2 ITGA2B ITGB3
6 cell surface GO:0009986 9.4 ADAMTS13 APOH CD40LG F3 GP1BA ITGA2
7 plasma membrane GO:0005886 10.22 CD40LG CD79A F2 F3 GP1BA ITGA2
8 extracellular exosome GO:0070062 10.13 APOH CRP F2 F3 GP1BA ITGA2B

Biological processes related to Purpura according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.89 ITGA2 ITGA2B ITGB3 TNF VWF
2 positive regulation of protein phosphorylation GO:0001934 9.87 F2 ITGB3 THPO TNF
3 platelet degranulation GO:0002576 9.85 APOH ITGA2B ITGB3 VWF
4 leukocyte migration GO:0050900 9.85 F2 ITGB3 PROC PROCR THBD TNF
5 cell-matrix adhesion GO:0007160 9.83 ADAMTS13 ITGA2 ITGA2B ITGB3
6 integrin-mediated signaling pathway GO:0007229 9.81 ADAMTS13 ITGA2 ITGA2B ITGB3
7 positive regulation of protein kinase B signaling GO:0051897 9.79 F3 THPO TNF
8 platelet aggregation GO:0070527 9.73 GP1BA ITGA2B ITGB3
9 blood coagulation GO:0007596 9.7 ADAMTS13 F2 F3 GP1BA ITGA2 ITGB3
10 cell-substrate adhesion GO:0031589 9.65 ITGA2 ITGB3 VWF
11 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.63 CRP ITGB3
12 negative regulation of blood coagulation GO:0030195 9.63 APOH PROC THBD
13 platelet activation GO:0030168 9.63 ADAMTS13 CD40LG F2 GP1BA ITGB3 VWF
14 positive regulation of positive chemotaxis GO:0050927 9.62 F3 ITGA2
15 mesodermal cell differentiation GO:0048333 9.62 ITGA2 ITGB3
16 regulation of blood coagulation GO:0030193 9.62 APOH F2 GP1BA SERPINC1
17 peptidyl-glutamic acid carboxylation GO:0017187 9.61 F2 PROC
18 negative regulation of fibrinolysis GO:0051918 9.61 APOH F2 THBD
19 response to amine GO:0014075 9.6 ADAMTS13 ITGA2
20 negative regulation of platelet activation GO:0010544 9.59 F2 THBD
21 negative regulation of coagulation GO:0050819 9.58 PROC PROCR
22 regulation of immunoglobulin secretion GO:0051023 9.58 CD40LG TNF
23 negative regulation of lipid storage GO:0010888 9.58 CRP ITGB3 TNF
24 blood coagulation, intrinsic pathway GO:0007597 9.56 APOH F2 GP1BA VWF
25 thrombopoietin-mediated signaling pathway GO:0038163 9.54 MPL THPO
26 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 GP1BA PROC PROCR

Molecular functions related to Purpura according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 ADAMTS13 APOH CD40LG CD79A CRP F2
2 protease binding GO:0002020 9.02 F3 ITGB3 SERPINC1 TNF VWF

Sources for Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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