MCID: PRP030
MIFTS: 67

Purpura malady

Summaries for Purpura

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63Wikipedia, 32MalaCards
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Wikipedia:63 Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on... more...

MalaCards: Purpura, also known as purpuric disorder, is related to autoimmune thrombocytopenic purpura and hemolytic-uremic syndrome. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Collagen biosynthesis and modifying enzymes and Platelet activation, signaling and aggregation. The drugs epoprostenol and epoprostenol sodium and the compounds fibrinogen and cysteine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Purpura

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

purpura 8 44 60
purpuric disorder 8
purpura nos 8


External Ids:

Disease Ontology8 DOID:3326
MeSH34 D011693
NCIt39 C78787

Related Diseases for Purpura

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17GeneCards, 18GeneDecks
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Diseases related to Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 580)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune thrombocytopenic purpura31.4SELP, THPO, IL11, MPL, ITGB3, IFNA2
2hemolytic-uremic syndrome30.9ADAMTS13, THBD, VWF
3thrombocytopenia30.8ADAMTS13, SERPINC1, SELP, THPO, THBD, VWF
4systemic lupus erythematosus30.7ADAMTS13, THBD, FCGR2C, VWF, F3, CD79A
5lupus erythematosus30.7APOH, IFNA2
6protein c deficiency30.7SERPINC1, THBD, PROC, PROCR, F5, APOH
7hepatitis30.7SELP, THPO, IFNA2
8thrombotic thrombocytopenic purpura, acquired30.7ADAMTS13, SELP, THBD, THBS1, VWF, F3
9vasculitis30.6SELP, THBD, VWF, CD79A, CD40LG, APOH
10glomerulonephritis30.6CD79A, CD40LG
11disseminated intravascular coagulation30.5ADAMTS13, SERPINC1, THPO, THBD, F3, PROC
12protein s deficiency30.5SERPINC1, F3, F5, APOH
13hemolytic anemia30.5ADAMTS13, VWF, F3, APOH, IFNA2
14hepatitis c30.5THPO, CD40LG, IFNA2
15pneumonia30.4IL11, CD79A
16leukemia30.4THPO, IL11, CD79A, CD40LG, MPL, ITGA2B
17myeloma30.4IL11, CD79A, CD40LG, IFNA2
18autoimmune hemolytic anemia30.4CD79A, CD40LG
19pancreatitis30.4SELP, IL11
20antiphospholipid syndrome30.3ADAMTS13, SERPINC1, SELP, THBD, VWF, F3
21connective tissue disease30.3THBD, VWF, F3, CD79A, CD40LG, APOH
22polyarteritis nodosa30.3IFNA2
23meningitis30.3CD79A
24mixed connective tissue disease30.3APOH
25myocardial infarction30.2ADAMTS13, SERPINC1, SELP, VWF, F3, IL11
26evans' syndrome30.2ADAMTS13
27cryoglobulinemia30.2CD79A, CD40LG, APOH, IFNA2
28purpura fulminans30.1SERPINC1, PROC, PROCR, F5
29hypertension30.1CD79A, F5
30arthritis30.1THBS1
31malaria30.1ADAMTS13
32hellp syndrome30.1ADAMTS13, SERPINC1, VWF, F5, APOH
33ulcerative colitis30.1SELP, THPO, IL11, CD79A, PROCR
34ischemia30.1ADAMTS13, SELP
35aplastic anemia30.1THPO, IL11, MPL
36dermatitis30.1CD79A
37wiskott-aldrich syndrome30.1THPO
38mumps30.1CD79A
39measles30.1CD79A, CD40LG
40rheumatoid arthritis30.0SELP, THPO, IL11, CD79A, CD40LG, ITGB3
41liver cirrhosis30.0ADAMTS13, SERPINC1, THPO, F3, IL11, IFNA2
42hemorrhagic disease30.0SERPINC1, THBD, VWF, F3, F5
43coronary thrombosis30.0SERPINC1, VWF, F3, ITGB3
44retinal vein occlusion30.0SERPINC1, F5, APOH
45portal vein thrombosis30.0SERPINC1, THPO, F5
46systemic scleroderma30.0THBD, VWF, CD40LG, APOH
47stroke, ischemic30.0F5, ITGA2B
48central retinal vein occlusion30.0F5, APOH
49adenocarcinoma30.0THBD, THBS1
50acquired thrombocytopenia30.0THPO, IL11

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Clinical Features for Purpura

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Drugs & Therapeutics for Purpura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Purpura

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Anatomical Context for Purpura

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32MalaCards
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MalaCards organs/tissues related to Purpura:

32
Skin, T cells, Endothelial, Bone, Liver, Bone marrow, B cells, Kidney, Lung, Testes, Heart, Spleen, Monocytes, Prostate, Breast, Colon, Brain, Pituitary, Thyroid, Retina, Smooth muscle, Appendix, Pancreatic islet, Pancreas, Myeloid, Testis, Lymph node, Cortex

Animal Models for Purpura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Purpura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.9PROC, PROCR, MPL, F5, ITGA2B, ITGB3
2MP:000539711.9ADAMTS13, ITGB3, ITGA2B, MPL, PROCR, PROC
3MP:000538711.9CD40LG, PROC, PROCR, MPL, ITGA2B, ITGB3
4MP:001076811.7PROC, PROCR, MPL, F5, ITGB3, APOH
5MP:000537011.1ITGB3, F5, PROC, THBS1, THBD, SELP
6MP:000538511.1ITGB3, ITGA2B, CD40LG, F3, THBS1, SELP
7MP:000538010.8ITGA2B, F5, PROCR, F3, THBD, SERPINC1
8MP:000538410.7MPL, CD79A, F3, VWF, THBS1, THBD
9MP:000536710.6THBS1, ITGB3
10MP:001077110.6CD40LG

Publications for Purpura

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50PubMed
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Articles related to Purpura:

(show top 50)    (show all 2349)
idTitleAuthorsYear
1
Lack of benefit of steroids for the prevention of Henoch-SchAPnlein purpura-associated nephritis. (24397455)
2014
2
Novel frameshift mutations in ADAMTS13 in two families with hereditary thrombotic thrombocytopenic purpura. (23677910)
2013
3
Autoimmune hepatitis-primary biliary cirrhosis overlap syndrome concomitant with immune hemolytic anemia and immune thrombocytopenic purpura (Evans syndrome). (23273499)
2013
4
The Oklahoma Thrombotic Thrombocytopenic Purpura-haemolytic Uraemic Syndrome Registry. A model for clinical research, education and patient care. (23364684)
2013
5
Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura. (22851056)
2012
6
T cell immunoglobulin and mucin-domain containing molecule 1 in peripheral blood mononuclear cells in Henoch Schonlein purpura. (22080624)
2012
7
Two cases of infectious purpura fulminans and septic shock caused by Capnocytophaga canimorsus transmitted from dogs. (22497463)
2012
8
Short- and long-term effects of rituximab for the treatment of thrombotic thrombocytopenic purpura: four case reports. (22878941)
2012
9
Superior mesenteric artery syndrome: risk factor for duodenal involvement in Henoch-SchAPnlein purpura. (21129122)
2011
10
Expression and significance of interleukin-23 and its related cytokines in chronic idiopathic thrombocytopenic purpura]. (21518507)
2011
11
Two cases of postoperative thrombotic thrombocytopenic purpura. (22107698)
2011
12
ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome. (21606162)
2011
13
Human immunodeficiency virus associated thrombotic thrombocytopenic purpura--favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy. (21391974)
2011
14
Autoimmune thrombocytopenic purpura in partial DiGeorge syndrome: case presentation. (21792043)
2011
15
Extensive thrombotic purpura revealing multiple myeloma associated - type I cryoglobulinemia. (21496001)
2011
16
Significance of B cell activating factor of TNF family promoter polymorphisms in patients with immune thrombocytopenic purpura]. (20561430)
2010
17
Platelet apoptosis resistance and increased CXCR4 expression in pediatric patients with chronic immune thrombocytopenic purpura. (20708218)
2010
18
HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians. (20141578)
2010
19
Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (19317746)
2009
20
Brain lesions are most often reversible in acute thrombotic thrombocytopenic purpura. (19564586)
2009
21
Cyclosporine therapy in refractory/relapsed patients with thrombotic thrombocytopenic purpura. (19306354)
2009
22
Limitations of ADAMTS-13 activity level in diagnosing thrombotic thrombocytopenic purpura in pregnancy. (19022799)
2009
23
Risk of immune thrombocytopenic purpura and autoimmune hemolytic anemia among 120 908 US veterans with hepatitis C virus infection. (19237719)
2009
24
Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis. (18339897)
2008
25
Antiphospholipid antibodies in adults with immune thrombocytopenic purpura. (18510681)
2008
26
A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura. (18166805)
2008
27
Thrombotic thrombocytopenic purpura complicating interferon therapy in chronic C hepatitis. (18496890)
2008
28
Evolution of ADAMTS13 antibodies in a fatal case of thrombotic thrombocytopenic purpura. (18661493)
2008
29
Successful treatment of septic shock with purpura fulminans caused by Trichosporon asahii in an immunocompetent patient. (18000295)
2007
30
Platelet activation in Helicobacter pylori-associated idiopathic thrombocytopenic purpura: eradication reduces platelet activation but seldom improves platelet counts. (16809885)
2006
31
Purpura fulminans due to Staphylococcus aureus. (15824983)
2005
32
The elevated markers of hypercoagulability in children with Henoch-SchAPnlein purpura. (15770830)
2005
33
A case of systemic amyloidosis associated with multiple myeloma presented as macroglossia and purpura. (15096165)
2004
34
Plasma therapy in thrombotic thrombocytopenic purpura: review of the literature and the Bern experience in a subgroup of patients with severe acquired ADAMTS-13 deficiency. (14727259)
2004
35
Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch-SchAPnlein purpura. (11361181)
2001
36
Myocardial injury in meningococcus-induced purpura fulminans in children. (11497141)
2001
37
The protective effect of brachial plexus palsy in purpura fulminans. (11516614)
2001
38
A case of purpura fulminans is caused by homozygous delta8857 mutation (protein C-nagoya) and successfully treated with activated protein C concentrate. (10997987)
2000
39
Scleredema adultorum associated with anaphylactoid purpura. (9111834)
1997
40
Treatment of chronic autoimmune thrombocytopenic purpura with monoclonal anti-D. (8623133)
1996
41
Vincristine for refractory autoimmune thrombocytopenic purpura in pregnancy. A case report. (8551481)
1995
42
Lack of IgA antineutrophil cytoplasmic antibodies in Henoch-SchAPnlein purpura and IgA nephropathy. (7923914)
1994
43
Drug-induced purpura simplex: clinical and histological characteristics. (8129346)
1993
44
Treatment of autoimmune thrombocytopenic purpura. (2131713)
1990
45
The surgical implications of purpura fulminans. (2340249)
1990
46
Henoch-schoenlein purpura. Gastrointestinal manifestations with endoscopic correlation. (7270530)
1981
47
Thrombotic thrombocytopenic purpura with optic disk neovascularization, vitreous hemorrhage, retinal detachment, and optic atrophy. (6155785)
1980
48
Association of antiplatelet antibody with functional platelet disorders. Autoimmune thrombocytopenic purpura, systemic lupus erythematosus and thrombopathia. (1106190)
1975
49
Subacute bacterial endocarditis presenting as purpura. (6058101)
1967
50
Thrombotic thrombocytopenic purpura. Report of a case with the unusual features of hypofibrinogenemia and leukopenia. (13874564)
1962

Genetic Variations for Purpura

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Expression for genes affiliated with Purpura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura

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Pathways for genes affiliated with Purpura

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53Reactome, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Pathways related to Purpura according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.1ITGB3, ITGA2B, F5, PROC, F3, THBS1
2
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11.0IFNA2, ITGB3, ITGA2B, F5, MPL, PROC
3
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10.9F3, VWF, THBS1, THBD, THPO, SELP
4
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10.9SERPINC1, THBD, VWF, F3, PROC, F5
5
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10.9F5, PROC, F3, VWF, THBD, SERPINC1
6
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10.9ITGB3, ITGA2B, F5, VWF, THBS1, SELP
7
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10.9IFNA2, ITGB3, ITGA2B, MPL, IL11, THPO
8
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10.9ITGB3, ITGA2B, MPL, VWF, THPO
9
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10.9F5, PROC, F3, THBD, SERPINC1
1010.9THBS1, VWF, ITGA2B, ITGB3, IFNA2
1110.8SELP, THBD, PROC, ITGB3
1210.8ITGB3, ITGA2B, IL11, THPO
13
Hide members
10.8THBS1, VWF, ITGA2B, ITGB3
1410.7VWF, ITGA2B, ITGB3
15
Hide members
10.7VWF, ITGA2B, ITGB3
16
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10.7ITGB3, ITGA2B, VWF
1710.7ITGB3, CD40LG, SELP

Compounds for genes affiliated with Purpura

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44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 208)
idCompoundScoreTop Affiliating Genes
1fibrinogen4412.2CD79A, IL11, F3, VWF, THBS1, THBD
2cysteine4412.0F3, IL11, CD79A, CD40LG, MPL, F5
3vegf4411.9SERPINC1, SELP, THPO, THBD, THBS1, VWF
4alanine4411.9CD40LG, THBS1, VWF, F3, CD79A, THBD
5aspirin44 49 28 2414.9CD79A, F3, VWF, THBD, THPO, SELP
6hirudin4411.7THPO, SELP, SERPINC1, F5, PROCR, CD40LG
7polyethylene glycol4411.6CD40LG, MPL, F5, IFNA2, CD79A, IL11
8retinoic acid44 2412.6CD40LG, F5, IFNA2, THPO, SELP, IL11
9cyclophosphamide44 49 1113.6F3, F5, APOH, IFNA2, IL11, THBS1
10prostacyclin4411.6THBS1, THBD, F3, F5, APOH, THPO
11epinephrine44 11 2413.6SELP, THPO, VWF, IFNA2, F5, CD40LG
12polysaccharide4411.5SELP, THBS1, CD79A, CD40LG, F5, THBD
13abciximab44 1112.5SERPINC1, SELP, FCGR2C, VWF, ITGB3, ITGA2B
14creatinine4411.5ADAMTS13, SELP, THPO, THBD, F3, APOH
15ristocetin4411.5SERPINC1, ADAMTS13, ITGB3, F5, F3, VWF
16tirofiban44 1112.5ITGB3, ITGA2B, CD40LG, F3, VWF, SELP
17heparin44 28 11 2414.5SELP, ADAMTS13, THPO, IL11, CD79A, CD40LG
18endotoxin4411.5ADAMTS13, THBD, F3, IL11, CD40LG, PROCR
19desmopressin44 59 28 1114.4F5, F3, VWF, THBD, SELP, SERPINC1
20txb24411.4THBD, SELP, IL11, VWF, F3, THBS1
21rituximab44 49 1113.4ADAMTS13, FCGR2C, IFNA2, APOH, CD40LG, CD79A
22warfarin44 49 11 2414.4SERPINC1, SELP, VWF, CD79A, PROC, APOH
23kininogen4411.4F5, F3, SERPINC1, THBS1, APOH, VWF
24ticlopidine44 1112.3SERPINC1, ADAMTS13, VWF, SELP, F3, APOH
25homocysteine44 2412.3F3, VWF, THBD, SELP, APOH, SERPINC1
26citrate4411.3THBD, SERPINC1, CD79A, F5, F3, SELP
27clopidogrel49 44 11 2414.3ITGB3, CD40LG, F3, VWF, SELP, SERPINC1
28histamine44 28 2413.3THBD, VWF, IL11, CD79A, CD40LG, IFNA2
29mycophenolate mofetil44 49 1113.3THBD, IL11, F5, CD40LG, CD79A, SELP
30hyaluronic acid44 2412.3THPO, CD40LG, CD79A, IL11, VWF, THBS1
31dextran sulfate4411.3F5, CD40LG, THBS1, SELP, APOH
32dermatan sulfate4411.3SERPINC1, SELP, THBD, F3, F5, VWF
33thromboxane44 2412.2THPO, SELP, THBD, VWF, MPL, APOH
34serine4411.2ADAMTS13, ITGA2B, THBS1, MPL, PROCR
35phosphatidylserine44 28 1113.2CD79A, F3, ITGB3, APOH
36bivalirudin44 1112.2SELP, F5, F3, THBD, SERPINC1
37argatroban44 1112.2SERPINC1, SELP, F5, F3, THBD
38ppack4411.2CD40LG, SELP, F3, VWF, SERPINC1
39folate4411.2CD79A, VWF, SERPINC1, CD40LG, F5, APOH
40gamma-carboxyglutamic acid4411.1THBD, PROC, PROCR, F5, F3
41estrogen4411.1THPO, CD79A, APOH
42adp44 28 2413.1PROC, CD40LG, ITGA2B, MPL
43cyclosporin a44 28 5913.1ADAMTS13, SELP, THBD, THBS1, VWF, IL11
44aprotinin44 1112.1SERPINC1, F5, F3, VWF, SELP, THBD
45ximelagatran44 1111.9F3, SERPINC1, F5, THBD
46iloprost44 59 28 1113.9F3, SERPINC1, SELP, THPO, THBD
47heparinoids4410.9F5, F3, SERPINC1, THBD
48aspartate4410.9CD40LG, IL11
49fondaparinux4410.7THBD, SERPINC1, F3, F5
50gamma globulin4410.3IFNA2, VWF

GO Terms for genes affiliated with Purpura

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16Gene Ontology
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Cellular components related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6PROC, MPL, F5, ITGA2B, ITGB3, CD40LG
2extracellular spaceGO:00561511.6ADAMTS13, IFNA2, APOH, F5, CD40LG, IL11
3external side of plasma membraneGO:00989711.2ITGA2B, CD40LG, CD79A, VWF, THBS1, SELP
4integral to plasma membraneGO:00588711.0ITGB3, ITGA2B, MPL, PROCR, CD40LG, THBD
5extracellular regionGO:00557611.0SERPINC1, THBS1, VWF, IL11, PROC, F5
6cell surfaceGO:00998611.0APOH, F3, THBS1, THBD, ADAMTS13
7platelet alpha granule membraneGO:03109210.9SELP, ITGA2B, ITGB3
8extracellular matrixGO:03101210.9THBS1, VWF, F3, APOH
9platelet alpha granule lumenGO:03109310.6THBS1, VWF, F5
10platelet alpha granuleGO:03109110.3VWF, THBS1

Biological processes related to Purpura according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.8SERPINC1, IFNA2, ITGB3, SELP, THPO, THBD
2platelet activationGO:03016811.6ADAMTS13, SELP, THPO, THBS1, VWF, IL11
3platelet degranulationGO:00257611.2ITGB3, ITGA2B, F5, VWF, THBS1, SELP
4cell adhesionGO:00715511.1ITGB3, ITGA2B, F5, VWF, THBS1, SELP
5leukocyte migrationGO:05090010.9SELP, THBD, PROC, ITGB3
6negative regulation of fibrinolysisGO:05191810.9APOH, THBS1, THBD
7negative regulation of blood coagulationGO:03019510.9THBD, PROC, APOH
8B cell differentiationGO:03018310.8CD40LG, CD79A, IL11
9integrin-mediated signaling pathwayGO:00722910.8ADAMTS13, ITGA2B, ITGB3
10cell-matrix adhesionGO:00716010.7ITGB3, ITGA2B, ADAMTS13
11B cell proliferationGO:04210010.6CD79A, CD40LG
12positive regulation of endothelial cell apoptotic processGO:200035310.5THBS1, CD40LG
13positive regulation of blood coagulationGO:03019410.3THBS1, APOH

Molecular functions related to Purpura according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8PROCR, F5, ITGA2B, ITGB3, APOH, IFNA2
2glycoprotein bindingGO:00194811.0SELP, THBS1, VWF, APOH
3transmembrane signaling receptor activityGO:00488810.9MPL, CD79A, FCGR2C, THBD
4heparin bindingGO:00820110.9APOH, THBS1, SELP, SERPINC1
5cytokine activityGO:00512510.8THPO, IL11, CD40LG, IFNA2
6integrin bindingGO:00517810.7ADAMTS13, THBS1, VWF
7protease bindingGO:00202010.6F3, VWF, SERPINC1
8identical protein bindingGO:04280210.6THBS1, VWF, ITGA2B, ITGB3, APOH

Products for genes affiliated with Purpura

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  • Antibodies
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Sources for Purpura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet