MCID: PRP030
MIFTS: 67

Purpura malady

Summaries for Purpura

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63Wikipedia, 32MalaCards
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Wikipedia:63 Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on... more...

MalaCards: Purpura, also known as purpuric disorder, is related to autoimmune thrombocytopenic purpura and hemolytic-uremic syndrome. An important gene associated with Purpura is ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13), and among its related pathways are Collagen biosynthesis and modifying enzymes and Platelet activation, signaling and aggregation. The drugs epoprostenol and epoprostenol sodium and the compounds fibrinogen and cysteine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Purpura

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

purpura 8 44 60
purpuric disorder 8
purpura nos 8


External Ids:

Disease Ontology8 DOID:3326
MeSH34 D011693
NCIt39 C78787

Related Diseases for Purpura

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17GeneCards, 18GeneDecks
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Diseases related to Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 580)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune thrombocytopenic purpura31.4SELP, THPO, IL11, MPL, ITGB3, IFNA2
2hemolytic-uremic syndrome30.9ADAMTS13, THBD, VWF
3thrombocytopenia30.8ADAMTS13, SERPINC1, SELP, THPO, THBD, VWF
4systemic lupus erythematosus30.7ADAMTS13, THBD, FCGR2C, VWF, F3, CD79A
5lupus erythematosus30.7APOH, IFNA2
6protein c deficiency30.7SERPINC1, THBD, PROC, PROCR, F5, APOH
7hepatitis30.7SELP, THPO, IFNA2
8thrombotic thrombocytopenic purpura, acquired30.7ADAMTS13, SELP, THBD, THBS1, VWF, F3
9vasculitis30.6SELP, THBD, VWF, CD79A, CD40LG, APOH
10glomerulonephritis30.6CD79A, CD40LG
11disseminated intravascular coagulation30.5ADAMTS13, SERPINC1, THPO, THBD, F3, PROC
12protein s deficiency30.5SERPINC1, F3, F5, APOH
13hemolytic anemia30.5ADAMTS13, VWF, F3, APOH, IFNA2
14hepatitis c30.5THPO, CD40LG, IFNA2
15pneumonia30.4IL11, CD79A
16leukemia30.4THPO, IL11, CD79A, CD40LG, MPL, ITGA2B
17myeloma30.4IL11, CD79A, CD40LG, IFNA2
18autoimmune hemolytic anemia30.4CD79A, CD40LG
19pancreatitis30.4SELP, IL11
20antiphospholipid syndrome30.3ADAMTS13, SERPINC1, SELP, THBD, VWF, F3
21connective tissue disease30.3THBD, VWF, F3, CD79A, CD40LG, APOH
22polyarteritis nodosa30.3IFNA2
23meningitis30.3CD79A
24mixed connective tissue disease30.3APOH
25myocardial infarction30.2ADAMTS13, SERPINC1, SELP, VWF, F3, IL11
26evans' syndrome30.2ADAMTS13
27cryoglobulinemia30.2CD79A, CD40LG, APOH, IFNA2
28purpura fulminans30.1SERPINC1, PROC, PROCR, F5
29hypertension30.1CD79A, F5
30arthritis30.1THBS1
31malaria30.1ADAMTS13
32hellp syndrome30.1ADAMTS13, SERPINC1, VWF, F5, APOH
33ulcerative colitis30.1SELP, THPO, IL11, CD79A, PROCR
34ischemia30.1ADAMTS13, SELP
35aplastic anemia30.1THPO, IL11, MPL
36dermatitis30.1CD79A
37wiskott-aldrich syndrome30.1THPO
38mumps30.1CD79A
39measles30.1CD79A, CD40LG
40rheumatoid arthritis30.0SELP, THPO, IL11, CD79A, CD40LG, ITGB3
41liver cirrhosis30.0ADAMTS13, SERPINC1, THPO, F3, IL11, IFNA2
42hemorrhagic disease30.0SERPINC1, THBD, VWF, F3, F5
43coronary thrombosis30.0SERPINC1, VWF, F3, ITGB3
44retinal vein occlusion30.0SERPINC1, F5, APOH
45portal vein thrombosis30.0SERPINC1, THPO, F5
46systemic scleroderma30.0THBD, VWF, CD40LG, APOH
47stroke, ischemic30.0F5, ITGA2B
48central retinal vein occlusion30.0F5, APOH
49adenocarcinoma30.0THBD, THBS1
50acquired thrombocytopenia30.0THPO, IL11

Graphical network of the top 20 diseases related to Purpura:



Diseases related to purpura

Clinical Features for Purpura

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Drugs & Therapeutics for Purpura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Purpura

Search NIH Clinical Center for Purpura

Search CenterWatch for Purpura

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Purpura

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Anatomical Context for Purpura

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32MalaCards
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MalaCards organs/tissues related to Purpura:

32
Skin, T cells, Endothelial, Bone, Liver, Bone marrow, B cells, Kidney, Lung, Testes, Heart, Spleen, Monocytes, Prostate, Breast, Colon, Brain, Pituitary, Thyroid, Retina, Smooth muscle, Appendix, Pancreatic islet, Pancreas, Myeloid, Testis, Lymph node, Cortex

Animal Models for Purpura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Purpura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.9PROC, PROCR, MPL, F5, ITGA2B, ITGB3
2MP:000539711.9ADAMTS13, ITGB3, ITGA2B, MPL, PROCR, PROC
3MP:000538711.9CD40LG, PROC, PROCR, MPL, ITGA2B, ITGB3
4MP:001076811.7PROC, PROCR, MPL, F5, ITGB3, APOH
5MP:000537011.1ITGB3, F5, PROC, THBS1, THBD, SELP
6MP:000538511.1ITGB3, ITGA2B, CD40LG, F3, THBS1, SELP
7MP:000538010.8ITGA2B, F5, PROCR, F3, THBD, SERPINC1
8MP:000538410.7MPL, CD79A, F3, VWF, THBS1, THBD
9MP:000536710.6THBS1, ITGB3
10MP:001077110.6CD40LG

Publications for Purpura

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50PubMed
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Articles related to Purpura:

(show top 50)    (show all 2349)
idTitleAuthorsYear
1
Thrombotic thrombocytopenic purpura in children. (23422353)
2013
2
Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura. (23346910)
2013
3
Thrombotic thrombocytopenic purpura (TTP)-like illness associated with intravenous Opana ER abuse--Tennessee, 2012. (23302815)
2013
4
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. (23410558)
2013
5
Henoch-SchAPnlein Purpura during Isotretinoin Therapy. (23463835)
2013
6
Effects of hemoperfusion in the treatment of childhood Henoch-SchAPnlein purpura nephritis. (23661557)
2013
7
Transfusion medicine illustrated. Massive hemolysis due to thrombotic thrombocytopenic purpura in a patient with AIDS. (22780894)
2012
8
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. (22265954)
2012
9
Octaploidy in idiopathic thrombocytopenia purpura: Is it incidental or causal? (23716955)
2012
10
The combination of mycophenolate mofetil with corticosteroids induces remission of Henoch-SchAPnlein purpura nephritis. (22965140)
2012
11
Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura. (22529288)
2012
12
Immune thrombocytopenic purpura following anti-rabies vaccines. (22360731)
2012
13
A case of purpura fulminans arising from cryptococcosis. (22753692)
2012
14
Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. (21496883)
2011
15
Atypical presentation of purpura fulminans following sepsis in an adult. (22675087)
2011
16
Case series: splenectomy: does it still play a role in the management of thrombotic thrombocytopenic purpura? (20858382)
2010
17
Relapsing or refractory idiopathic thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the role of rituximab. (20576013)
2010
18
Pathogenesis and treatment of acquired idiopathic thrombotic thrombocytopenic purpura. (20807984)
2010
19
Urinary excretion and renal production of hepatocyte growth factor in children with Henoch-SchAPnlein purpura. (21226996)
2010
20
Henoch-SchAPnlein purpura in a child with Guillain-BarrAc syndrome. (21093736)
2010
21
The challenges of diagnosing thrombotic thrombocytopenic purpura in the critically ill. A case report. (20691639)
2010
22
Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura. (20056836)
2010
23
Henoch-ShAPnlein purpura]. (19345173)
2009
24
Serum and urine VEGF concentration of different pathological types in children with Henoch Schonlein purpura nephritis]. (20045916)
2009
25
Foot-drop: an unusual complaint in Henoch-SchAPnlein purpura. (18773224)
2009
26
Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review. (19483158)
2009
27
The spectrum of thrombotic thrombocytopenic purpura: a clinicopathologic demonstration of tacrolimus-induced thrombotic thrombocytopenic purpura in a lung transplant patient. (18580733)
2008
28
Interferon-gamma +874A/T and interleukin-4 intron3 VNTR gene polymorphisms in Chinese patients with idiopathic thrombocytopenic purpura. (17655693)
2007
29
Safety and usefulness of invasive arterial blood pressure monitoring in purpura fulminans resuscitation. (17392648)
2007
30
Plasma levels of matrix metalloproteinase-9 in Henoch-SchAPnlein purpura. (16467043)
2006
31
A clinical study of congenital thrombotic thrombocytopenic purpura]. (16831327)
2006
32
Increased frequency of C4B*Q0 alleles in patients with Henoch-SchAPnlein purpura. (15787745)
2005
33
Severe autoimmune thrombocytopenic purpura during interferon-alpha therapy for chronic myelogenous leukemia. (15564735)
2004
34
A woman suffering from systemic lupus erythematosus and acquired thrombotic thrombocytopenic purpura]. (15524134)
2004
35
Characteristics of Helicobacter pylori-induced gastritis and the effect of H. pylori eradication in patients with chronic idiopathic thrombocytopenic purpura. (15361084)
2004
36
Homozygous protein C deficiency with purpura fulminans: report of a new case and a description of a novel mutation. (12695756)
2003
37
Role of transforming growth factor-beta 1 gene polymorphisms in childhood idiopathic thrombocytopenic purpura. (14608199)
2003
38
Purpura with cold urticaria in a patient with hepatitis C virus infection-associated mixed cryoglobulinemia type III: successful treatment with interferon-beta. (12707469)
2003
39
Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor. (12384150)
2002
40
Klebsiella-induced purpura fulminans in a Nigerian child: case report and a review of literature. (12744583)
2002
41
Transradial coronary stent placement in a patient with severe idiopathic autoimmune thrombocytopenic purpura. (10904444)
2000
42
Idiopathic thrombocytopenic purpura associated with Crohn's disease. (9542329)
1998
43
Increased thrombopoietin levels in idiopathic thrombocytopenic purpura patients with a poor response to steroid therapy. (9690802)
1998
44
Thrombotic thrombocytopenic purpura in a patient with diffuse scleroderma. (9251403)
1996
45
Henoch-SchAPnlein purpura in a patient with diabetic nephropathy. (8079978)
1994
46
Capillaritis (purpura simplex) associated with use of aminoglutethimide in Cushing's syndrome. (7847422)
1994
47
A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans. (7841324)
1994
48
Antiplatelet autoantibody-related microparticles in patients with idiopathic (autoimmune) thrombocytopenic purpura. (2031972)
1991
49
Magnetic resonance imaging of central nervous system vasculitis. A case report of Henoch-SchAPnlein purpura. (2386069)
1990
50
Purpura fulminans. (657839)
1978

Genetic Variations for Purpura

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Expression for genes affiliated with Purpura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for genes affiliated with Purpura

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53Reactome, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Pathways related to Purpura according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1ITGB3, ITGA2B, F5, PROC, F3, THBS1
2
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11.0IFNA2, ITGB3, ITGA2B, F5, MPL, PROC
3
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10.9F3, VWF, THBS1, THBD, THPO, SELP
4
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10.9SERPINC1, THBD, VWF, F3, PROC, F5
5
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10.9F5, PROC, F3, VWF, THBD, SERPINC1
6
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10.9ITGB3, ITGA2B, F5, VWF, THBS1, SELP
7
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10.9IFNA2, ITGB3, ITGA2B, MPL, IL11, THPO
8
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10.9ITGB3, ITGA2B, MPL, VWF, THPO
9
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10.9F5, PROC, F3, THBD, SERPINC1
1010.9THBS1, VWF, ITGA2B, ITGB3, IFNA2
1110.8SELP, THBD, PROC, ITGB3
1210.8ITGB3, ITGA2B, IL11, THPO
13
Hide members
10.8THBS1, VWF, ITGA2B, ITGB3
1410.7VWF, ITGA2B, ITGB3
15
Hide members
10.7VWF, ITGA2B, ITGB3
16
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10.7ITGB3, ITGA2B, VWF
1710.7ITGB3, CD40LG, SELP

Compounds for genes affiliated with Purpura

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44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 208)
idCompoundScoreTop Affiliating Genes
1fibrinogen4412.2CD79A, IL11, F3, VWF, THBS1, THBD
2cysteine4412.0F3, IL11, CD79A, CD40LG, MPL, F5
3vegf4411.9SERPINC1, SELP, THPO, THBD, THBS1, VWF
4alanine4411.9CD40LG, THBS1, VWF, F3, CD79A, THBD
5aspirin44 49 28 2414.9CD79A, F3, VWF, THBD, THPO, SELP
6hirudin4411.7THPO, SELP, SERPINC1, F5, PROCR, CD40LG
7polyethylene glycol4411.6CD40LG, MPL, F5, IFNA2, CD79A, IL11
8retinoic acid44 2412.6CD40LG, F5, IFNA2, THPO, SELP, IL11
9cyclophosphamide44 49 1113.6F3, F5, APOH, IFNA2, IL11, THBS1
10prostacyclin4411.6THBS1, THBD, F3, F5, APOH, THPO
11epinephrine44 11 2413.6SELP, THPO, VWF, IFNA2, F5, CD40LG
12polysaccharide4411.5SELP, THBS1, CD79A, CD40LG, F5, THBD
13abciximab44 1112.5SERPINC1, SELP, FCGR2C, VWF, ITGB3, ITGA2B
14creatinine4411.5ADAMTS13, SELP, THPO, THBD, F3, APOH
15ristocetin4411.5SERPINC1, ADAMTS13, ITGB3, F5, F3, VWF
16tirofiban44 1112.5ITGB3, ITGA2B, CD40LG, F3, VWF, SELP
17heparin44 28 11 2414.5SELP, ADAMTS13, THPO, IL11, CD79A, CD40LG
18endotoxin4411.5ADAMTS13, THBD, F3, IL11, CD40LG, PROCR
19desmopressin44 59 28 1114.4F5, F3, VWF, THBD, SELP, SERPINC1
20txb24411.4THBD, SELP, IL11, VWF, F3, THBS1
21rituximab44 49 1113.4ADAMTS13, FCGR2C, IFNA2, APOH, CD40LG, CD79A
22warfarin44 49 11 2414.4SERPINC1, SELP, VWF, CD79A, PROC, APOH
23kininogen4411.4F5, F3, SERPINC1, THBS1, APOH, VWF
24ticlopidine44 1112.3SERPINC1, ADAMTS13, VWF, SELP, F3, APOH
25homocysteine44 2412.3F3, VWF, THBD, SELP, APOH, SERPINC1
26citrate4411.3THBD, SERPINC1, CD79A, F5, F3, SELP
27clopidogrel49 44 11 2414.3ITGB3, CD40LG, F3, VWF, SELP, SERPINC1
28histamine44 28 2413.3THBD, VWF, IL11, CD79A, CD40LG, IFNA2
29mycophenolate mofetil44 49 1113.3THBD, IL11, F5, CD40LG, CD79A, SELP
30hyaluronic acid44 2412.3THPO, CD40LG, CD79A, IL11, VWF, THBS1
31dextran sulfate4411.3F5, CD40LG, THBS1, SELP, APOH
32dermatan sulfate4411.3SERPINC1, SELP, THBD, F3, F5, VWF
33thromboxane44 2412.2THPO, SELP, THBD, VWF, MPL, APOH
34serine4411.2ADAMTS13, ITGA2B, THBS1, MPL, PROCR
35phosphatidylserine44 28 1113.2CD79A, F3, ITGB3, APOH
36bivalirudin44 1112.2SELP, F5, F3, THBD, SERPINC1
37argatroban44 1112.2SERPINC1, SELP, F5, F3, THBD
38ppack4411.2CD40LG, SELP, F3, VWF, SERPINC1
39folate4411.2CD79A, VWF, SERPINC1, CD40LG, F5, APOH
40gamma-carboxyglutamic acid4411.1THBD, PROC, PROCR, F5, F3
41estrogen4411.1THPO, CD79A, APOH
42adp44 28 2413.1PROC, CD40LG, ITGA2B, MPL
43cyclosporin a44 28 5913.1ADAMTS13, SELP, THBD, THBS1, VWF, IL11
44aprotinin44 1112.1SERPINC1, F5, F3, VWF, SELP, THBD
45ximelagatran44 1111.9F3, SERPINC1, F5, THBD
46iloprost44 59 28 1113.9F3, SERPINC1, SELP, THPO, THBD
47heparinoids4410.9F5, F3, SERPINC1, THBD
48aspartate4410.9CD40LG, IL11
49fondaparinux4410.7THBD, SERPINC1, F3, F5
50gamma globulin4410.3IFNA2, VWF

GO Terms for genes affiliated with Purpura

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16Gene Ontology
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Cellular components related to Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6CD79A, ITGB3, ITGA2B, F5, MPL, PROC
2extracellular spaceGO:00561511.6CD40LG, IFNA2, APOH, F5, IL11, F3
3external side of plasma membraneGO:00989711.2CD79A, CD40LG, ITGA2B, VWF, SELP, THBS1
4integral to plasma membraneGO:00588711.0SELP, THBD, CD40LG, PROCR, MPL, ITGA2B
5extracellular regionGO:00557611.0SERPINC1, IFNA2, IL11, VWF, THBS1, F5
6cell surfaceGO:00998611.0F3, THBS1, THBD, ADAMTS13, APOH
7platelet alpha granule membraneGO:03109210.9ITGB3, ITGA2B, SELP
8extracellular matrixGO:03101210.9THBS1, APOH, F3, VWF
9platelet alpha granule lumenGO:03109310.6VWF, THBS1, F5
10platelet alpha granuleGO:03109110.3VWF, THBS1

Biological processes related to Purpura according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.8THPO, THBD, THBS1, VWF, F3, PROC
2platelet activationGO:03016811.6VWF, IL11, ADAMTS13, SELP, THPO, THBS1
3platelet degranulationGO:00257611.2VWF, F5, ITGA2B, ITGB3, THBS1, SELP
4cell adhesionGO:00715511.1THBS1, SELP, VWF, F5, ITGA2B, ITGB3
5leukocyte migrationGO:05090010.9ITGB3, THBD, PROC, SELP
6negative regulation of fibrinolysisGO:05191810.9APOH, THBD, THBS1
7negative regulation of blood coagulationGO:03019510.9APOH, PROC, THBD
8B cell differentiationGO:03018310.8IL11, CD79A, CD40LG
9integrin-mediated signaling pathwayGO:00722910.8ITGA2B, ITGB3, ADAMTS13
10cell-matrix adhesionGO:00716010.7ITGA2B, ADAMTS13, ITGB3
11B cell proliferationGO:04210010.6CD79A, CD40LG
12positive regulation of endothelial cell apoptotic processGO:200035310.5CD40LG, THBS1
13positive regulation of blood coagulationGO:03019410.3APOH, THBS1

Molecular functions related to Purpura according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8VWF, FCGR2C, THBS1, PROC, SELP, ADAMTS13
2glycoprotein bindingGO:00194811.0SELP, THBS1, VWF, APOH
3transmembrane signaling receptor activityGO:00488810.9MPL, CD79A, THBD, FCGR2C
4heparin bindingGO:00820110.9THBS1, SELP, SERPINC1, APOH
5cytokine activityGO:00512510.8IFNA2, THPO, IL11, CD40LG
6integrin bindingGO:00517810.7THBS1, ADAMTS13, VWF
7protease bindingGO:00202010.6VWF, SERPINC1, F3
8identical protein bindingGO:04280210.6VWF, ITGA2B, ITGB3, THBS1, APOH

Products for genes affiliated with Purpura

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Purpura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet