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MCID: PRP034

Purpura Fulminans malady
11 genes, 137 related diseases, clinical trials.

Summaries for Purpura Fulminans

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59Wikipedia, 29MalaCards
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Wikipedia:59 Purpura fulminans (also known as \"Purpura gangrenosa\") is a haemorrhagic condition usually associated... more...

MalaCards: Purpura Fulminans is related to protein s deficiency and thrombosis. An important gene associated with Purpura Fulminans is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Cell surface interactions at the vascular wall and PTM: gamma carboxylation, hypusine formation and arylsulfatase activation. The compounds heparin and prostacyclin have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and hematopoietic system.

Aliases & Classifications for Purpura Fulminans

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Sources:
45Orphanet, 56UMLS, 32MESH via Orphanet, 24ICD10 via Orphanet, 53SNOMED-CT via Orphanet, 57UMLS via Orphanet
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Aliases & Descriptions:

purpura fulminans 45 56

Classifications:


ICD10: 24


External Ids:

MESH via Orphanet32 D014884, D055665
ICD10 via Orphanet24 D65
SNOMED-CT via Orphanet53 13507004
UMLS via Orphanet57 C0043068, C0085650

Related Diseases for Purpura Fulminans

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16GeneCards, 17GeneDecks
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Diseases related to purpura fulminans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1protein s deficiency496.8SERPINC1, MTHFR, APOH, F5, F2, F3
2thrombosis493.7F3, F2, F5, APOH, C1S, MTHFR
3vitamin k deficiency hemorrhagic disease322.2F2, F3
4gonococcal synovitis322.2PROC, PROCR, PLAT, SERPINC1, C1S, F5
5adenocarcinoma322.2
6diabetes mellitus322.2PLAT, SERPINC1, MTHFR
7prostate cancer322.2
8prostatitis322.2
9thrombophilia322.2F3, F2, F5, APOH, MTHFR, SERPINC1
10deep vein thrombosis322.2APOH, MTHFR, SERPINC1, PLAT, PROCR, PROC
11purpura37.7SERPINC1
12meningococcemia31.2PROCR, SERPINC1, F5
13pneumonia30.5CSF3
14angioedema29.7C1S, PLAT
15protein c deficiency28.9F2, F5, APOH, MTHFR, SERPINC1, PROCR
16patent foramen ovale13.7F5
17ovarian hyperstimulation syndrome13.7F5
18acute pancreatitis13.6C1S
19nephrotic syndrome13.6SERPINC1
20pancreatitis13.6C1S
21thrombophlebitis13.6APOH
22urticaria13.5C1S
23primary hyperoxaluria13.5SERPINC1
24viral hepatitis13.5F2
25hepatitis a13.5F2
26hepatitis13.5F2
27alzheimer's disease13.4C1S
28multiple myeloma13.4CSF3
29macroglossia13.4C1S
30carotid artery thrombosis13.4F3
31myeloma13.4CSF3
32cryoglobulinemia13.4APOH
33glycogen storage disease13.4CSF3
34peritonitis13.4F2
35hepatitis c13.4F2
36ovarian cancer13.4CSF3
37central retinal artery occlusion13.4PLAT
38neutropenia13.4CSF3
39essential hypertension13.4PLAT
40capillary leak syndrome13.4C1S
41lung cancer13.4CSF3
42hepatitis b13.4F2
43venous insufficiency13.3PLAT
44cholestasis13.3F2
45sagittal sinus thrombosis13.3SERPINC1, F5
46age related macular degeneration13.3PLAT
47retinal artery occlusion13.3APOH, F5
48factor xii deficiency13.3F3, F5
49hepatocellular carcinoma13.3F2
50complement deficiency13.3C1S

Graphical network of the top 20 diseases related to purpura fulminans:



Diseases related to purpura fulminans

Symptoms for Purpura Fulminans

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Drugs & Therapeutics for Purpura Fulminans

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for purpura fulminans

Drug clinical trials:

Search ClinicalTrials for purpura fulminans

Search NIH Clinical Center for purpura fulminans

Search CenterWatch for purpura fulminans

Genetic Tests for Purpura Fulminans

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Anatomical Context for Purpura Fulminans

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Animal Models for Purpura Fulminans or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to purpura fulminans:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
nervous system phenotype
MP:00036319.6MTHFR
2
hematopoietic system phenotype
MP:00053979.1F2, PLAT, PROC
3
integument phenotype
MP:00107717.9CSF3, F3, F2, F5, MTHFR
4
cardiovascular system phenotype
MP:00053857.7F3, F2, F5, SERPINC1, PLAT, PROC
5
homeostasis/metabolism phenotype
MP:00053766.5MTHFR, PROC, F3, F2, F5, APOH
6
mortality/aging
MP:00107686.5APOH, PROC, PROCR, PLAT, SERPINC1, F3

Publications for Purpura Fulminans

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47PubMed
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Articles related to purpura fulminans:

(show all 34)
idTitleAuthorsYearAffiliating Genes
1Protein C (PROC) gene mutations in two Indian familie s with purpura fulminans. (20077116)Pai N.... Ghosh K.2010PROC
2Severe purpura fulminans due to coexistence of homozy gous protein C deficiency and homozygous methylenetetrahydrofolate reductase mu tation. (19954370)Demirel N.... Yarali N.2009MTHFR
3Purpura fulminans: a case series managed at a regional burn center. (18354305)Hassan Z.... Mian M.A.2008F5
4Modern concepts of the diagnosis and treatment of purpura fulminans. (18652566)Edlich R.F.... Long W.B.2008SERPINC1
5Pneumococcal purpura fulminans successfully treated w ith activated protein C. (18791506)Minhas K.M.... Parker J.2008F5
6Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)Celikel S.... Kalyoncu A.F.2007C1S, F5
7Treatment of acute infectious purpura fulminans with activated protein C. (16820663)Lokeshwar M.R.... Kapadia F.N.2006F5
8Purpura fulminans due to Staphylococcus aureus. (15824983)Kravitz G.R.... Schlievert P.M.2005F5
9Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)Edlich R.F.... Long W.B.2005F5
10Purpura fulminans as a sequel to erythema nodosum in a child with homozygous Leiden mutation and acquired protein S deficiency. (16188867)Bruun C.F.... Eriksson Steigen S.2005F5
11Homozygous type I Protein C deficiency in neonatal purpura fulminans with a novel frame-shift deletion of 10 base pairs in exon 8 of PROC gene. (15748260)Park H.J.... Kim M.J.2005PROC
12Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass. (15186640)Cone L.A.... Sofonio M.V.2004PROC, SERPINC1
13Recombinant human activated protein C in the treatme nt of children with meningococcal purpura fulminans (15469811)MartinA^n-Torres F.... MartinA^n SA!nchez J.M.2004F5
14Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. (14707707)Manco-Johnson M.J.... Knapp-Clevenger R.2004F5
15Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: a retrospective study. (15286558)Zenz W.... Faust S.N.2004PLAT
16Adult purpura fulminans associated with staphylococcal infection and administration of colony-stimulating factors. (12609794)Galimberti R.... Kowalczuk A.2003CSF3
17Purpura fulminans in a child with combined heterozygous prothrombin G20210A and factor V Leiden mutations. (12601492)Ozbek N.... Kayiran S.M.2003F5
18Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetic study. (12761614)Fourrier F.... Noizet O.2003SERPINC1
19Severe protein S deficiency associated with heterozygous factor V Leiden mutation in a child with purpura fulminans. (12687747)Dogan Y.... Gurgey A.2003F5
20Purpura fulminans and anticardiolipin antibodies in a patient with Grave's disease. (12492254)Ligier S.... Fortin P.R.2002APOH
21An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)White B.... Smith O.P.2000SERPINC1
22A case of purpura fulminans is caused by homozygous d elta8857 mutation (protein C-nagoya) and successfully treated with activated pr otein C concentrate. (10997987)Nakayama T.... Saito H.2000F5
23Postinfection purpura fulminans in a patient heterozygous for prothrombin G20210A and acquired protein S resistance. (10599098)l-Ismail S.... O'Hagan M.1999F5
24Homozygous Factor V Leiden mutation in a child with meningococcal purpura fulminans. (9469407)SaAskesen C.... Parlak H.1998F5
25Varicella purpura fulminans associated with heterozygosity for factor V leiden and transient protein S deficiency. (9794956)Woods C.R.... Johnson C.A.1998F5
26Adult purpura fulminans and digital necrosis associat ed with sepsis and the factor V mutation. (9846775)Jackson R.T.... Luplow R.E.1998F5
27Purpura fulminans in the newborn. Report of two cases successfully treated with heparin and antithrombin III (9577159)Ficuccilli F.... Colarizi P.1997F2, PROC, SERPINC1
28Purpura fulminans induced by disseminated intravascul ar coagulation following infection in 2 unrelated children with double heterozy gosity for factor V Leiden and protein S deficiency. (9241737)Inbal A.... Seligsohn U.1997F5
29Neonatal purpura fulminans in association with factor V R506Q mutation. (8627449)Pipe S.W.... Castle V.P.1996F5
30Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. (8774497)Manco-Johnson M.J.... Lefkowitz J.1996F2, F3
31Meningococcal purpura fulminans treated with antithrombin III concentrate: what is the optimal replacement therapy? (7848164)Cobcroft R.... Scott D.1994SERPINC1
32A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans. (7841324)Witt I.... Schenck W.1994PROC
33A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy. (7841323)Millar D.S.... Cooper D.N.1994PROC
34Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates. (2139671)Fourrier F.... Mangalaboyi J.1990SERPINC1

Variations for Purpura Fulminans

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Expression for genes affiliated with Purpura Fulminans

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Purpura Fulminans

Pathways for genes affiliated with Purpura Fulminans

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50Reactome, 46PharmGKB, 48QIAGEN, 34NCBI BioSystems Database, 49R&D Systems, 27KEGG
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Pathways related to purpura fulminans according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cell surface interactions at the vascular wall50
9.7F2, PROC
2
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation50
9.7PROC, F2
3
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins50
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9.3F3, F2, PROC
4
Common Pathway50
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9.0SERPINC1, F2, F5, PROC
5
Blood Coagulation Cascade48
Hide members
8.6F3, PROC, SERPINC1, F2, F5
6
Selenium Pathway34
8.5F2, MTHFR, PLAT
7
Platelet activation, signaling and aggregation50
Hide members
8.4PLAT, PROC, SERPINC1, F5, F2
8
Formation of Fibrin Clot (Clotting Cascade)50
Hide members
8.0PLAT, SERPINC1, F5, F2, F3, PROC
9
Complement and coagulation cascades27
Hide members
7.6PROC, F3, SERPINC1, C1S, F5, F2

Compounds for genes affiliated with Purpura Fulminans

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41Novoseek, 11DrugBank, 22HMDB, 46PharmGKB, 55Tocris Bioscience
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Compounds related to purpura fulminans according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1heparin41 11 2212.6C1S
2prostacyclin4110.1F3, C1S
3Drotrecogin alfa119.7PROCR, F2, F5
4spectrozyme419.5PLAT, SERPINC1, F3
5dextran 70419.5PLAT, F2
6hirugen419.5F5, SERPINC1, F2
7argatroban41 1110.5PLAT, SERPINC1, F3
8aspirin41 46 2211.5SERPINC1, C1S, F5, F3
9polybrene419.3F3, SERPINC1, F2
10efegatran419.3F3, SERPINC1, PLAT
11inogatran419.3F5, F2, F3, SERPINC1
12ecarin419.3SERPINC1, F5, F2, F3
13danaparoid419.3F2, F3, SERPINC1, F5
14ximelagatran41 1110.3SERPINC1, F5, F3, F2
15hepaplastin419.3SERPINC1, F2, F3
16heparinoids419.3SERPINC1, F5, F2, F3
17rivaroxaban41 1110.2F3, SERPINC1, F2
18heparin sodium419.2F3, F2, PLAT
19kaolin419.2F2, F3, F5, APOH
20coumarins419.1APOH, F3, F5, F2
21gamma-carboxyglutamic acid419.1F5, F2, F3, PROCR, PROC
22ancrod419.1PLAT, SERPINC1, F5, F2
23hydroxyethyl starch419.0SERPINC1, CSF3, F2, F3
24ticlopidine41 119.9PLAT, APOH, F3, SERPINC1
25cardiolipin41 119.9F2, F3, APOH, F5
26ppack418.9F3, F2, SERPINC1, PLAT
27fibrinopeptide a418.9SERPINC1, F2, PLAT
28phosphatidylethanolamine41 119.9PROCR, F5, F2, APOH
29tirofiban41 119.9SERPINC1, PLAT, F3, F2
30epsilon aminocaproic acid418.9F2, F3, PLAT, SERPINC1
31clopidogrel41 46 11 2211.8PLAT, F2, F3, SERPINC1
32batroxobin418.7F2, PLAT, F5
33fondaparinux418.7F3, F2, F5, SERPINC1, PLAT
34bivalirudin41 119.7PLAT, SERPINC1, F5, F2, F3
35protamine sulfate418.7SERPINC1, F5, F2, PLAT, F3
36ristocetin418.7F5, PLAT, SERPINC1, F3, F2
37levonorgestrel41 119.7PLAT, F3, F2, F5, SERPINC1
38desmopressin41 55 1110.7F5, SERPINC1, F3, F2, PLAT
39tranexamic acid41 119.6F2, C1S, SERPINC1, PLAT, F3
40protamine418.6SERPINC1, PLAT, F2, F3, F5
41abciximab41 119.6F2, F3, C1S, SERPINC1, PLAT
42phospholipid418.5F5, F3, F2, APOH, PROCR, PROC
43hirudin418.4F3, F2, SERPINC1, PLAT, PROCR, F5
44aprotinin41 119.3PLAT, SERPINC1, F2, F3, F5, C1S
45kininogen417.9F3, PLAT, SERPINC1, C1S, APOH, F5
46homocysteine41 228.4F5, MTHFR, F3, PLAT, SERPINC1, F2
47creatinine417.4PLAT, F3, APOH, F2, F5, MTHFR
48warfarin41 46 11 2210.2PROC, PLAT, SERPINC1, MTHFR, APOH, F2
49serine416.8F3, PROC, PROCR, PLAT, SERPINC1, MTHFR
50fibrinogen416.5F3, PROC, PROCR, F2, F5, APOH

GO Terms for genes affiliated with Purpura Fulminans

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15Gene Ontology
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Cellular components related to purpura fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4PROC, F2
2extracellular matrixGO:0310129.0F3, APOH, PLAT
3extracellular regionGO:0055767.9F2, PROC, PLAT, SERPINC1, C1S, F5
4extracellular spaceGO:0056157.3APOH, PLAT, SERPINC1, CSF3, F5, F2

Biological processes related to purpura fulminans according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.9PROC, F2
2leukocyte migrationGO:0509009.7PROC, F2
3negative regulation of blood coagulationGO:0301959.6APOH, PROC
4positive regulation of blood coagulationGO:0301949.6F2, APOH
5negative regulation of fibrinolysisGO:0519189.6F2, APOH
6plasminogen activationGO:0316399.5APOH, PLAT
7fibrinolysisGO:0427309.5F2, PLAT
8negative regulation of proteolysisGO:0458619.3F2, PLAT
9blood coagulation, intrinsic pathwayGO:0075979.2F2, APOH
10proteolysisGO:0065088.9PROC, PLAT, C1S, F2
11blood coagulationGO:0075967.9F3, F2, F5, SERPINC1, PLAT, PROCR

Molecular functions related to purpura fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.7F2, C1S, PLAT, PROC

Products for genes affiliated with Purpura Fulminans

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  • Antibodies
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Sources for Purpura Fulminans

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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