MCID: PRP034
MIFTS: 42

Purpura Fulminans malady

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Purpura Fulminans

About this section

Summaries for Purpura Fulminans

About this section
Disease Ontology:11 A purpura characterized blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. It is often fatal.

MalaCards based summary: Purpura Fulminans, also known as purpura gangrenosa, is related to thrombophilia and acquired purpura fulminans, and has symptoms including cullen's sign and mucocutaneous haemorrhage. An important gene associated with Purpura Fulminans is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are cardiovascular system and embryo.

Wikipedia:70 Purpura fulminans (also known as \"Purpura gangrenosa\") is an acute, often fatal, thrombotic disorder... more...

Related Diseases for Purpura Fulminans

About this section

Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia29.7F2, SERPINC1
2acquired purpura fulminans12.2
3thrombophilia due to protein c deficiency, autosomal recessive11.2
4thrombophilia due to protein s deficiency, autosomal recessive11.2
5purpura11.0
6protein c deficiency10.4
7catatrichy10.3F3, PROC
8familial glomangioma10.3F2, F3
9protein s deficiency10.3
10cerebral angioma10.3F2, F3
11dislocation of ear ossicle10.3F2, F3
12von willibrand disease, type 310.3F2, F3
13epididymo-orchitis10.3F2, F3
14chorea gravidarum10.3F2, F3
15central nervous system germinoma10.2F2, F3
16congenital nystagmus10.2F2, F3
17peroneal neuropathy10.2F2, F3
18splenic infarction10.2F2, F3
19wfs1-related disorders10.2F2, F3
20pneumonia10.2
21meningococcemia10.2
22facioscapulohumeral muscular dystrophy 110.2F2, F3
23cercarial dermatitis10.2F2, F3
24disseminated intravascular coagulation10.2
25idiopathic central precocious puberty10.2F2, F3
26subcortical arteriosclerotic encephalopathy10.2F2, SERPINC1
27artery disease10.2F2, F3
28infantile-onset ascending hereditary spastic paralysis10.2F2, F3
29factor x deficiency10.2F2, F3
30collagenous colitis10.2F2, SERPINC1
31hypertensive heart disease10.2F2, SERPINC1
32spleen cancer10.2F2, SERPINC1
33thrombophilia due to thrombin defect10.2F2, SERPINC1
34posterolateral myocardial infarction10.2F2, SERPINC1
35thrombocytopenia with elevated serum iga and renal disease10.2F2, F3
36may-hegglin anomaly10.2F2, SERPINC1
37left-right axis malformations10.1F2, SERPINC1
38scapuloperoneal myopathy, x-linked dominant10.1F2, F3
39polyhydramnios10.1F2, SERPINC1
40meningitis10.1
41histoplasmosis10.1F2, SERPINC1
42cavernous sinus thrombosis10.1F3, SERPINC1
43hepatic fibrosis renal cysts mental retardation10.1F3, SERPINC1
44budd-chiari syndrome10.1F2, SERPINC1
45selective iga deficiency disease10.1F2, SERPINC1
46hepatic coma10.1F2, F3
47chickenpox10.1
48anterior foramen magnum meningioma10.1F2, SERPINC1
49apocrine adenoma10.1F2, F3
50joint disorders10.1F2, SERPINC1

Graphical network of the top 20 diseases related to Purpura Fulminans:



Diseases related to purpura fulminans

Symptoms for Purpura Fulminans

About this section

UMLS symptoms related to Purpura Fulminans:


cullen's sign, mucocutaneous haemorrhage

Drugs & Therapeutics for Purpura Fulminans

About this section

Drugs for Purpura Fulminans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Protein CPhase 2, Phase 3115
2Fibrinolytic AgentsPhase 2, Phase 32317
3AnticoagulantsPhase 2, Phase 32516
4
Hydrocortisoneapproved, vet_approvedPhase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11╬▓-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
5
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
6Hydrocortisone-17-butyratePhase 2318
7Hydrocortisone acetatePhase 2640
8Hydrocortisone 17-butyrate 21-propionatePhase 2640
9Anti-Inflammatory AgentsPhase 210355
10Cortisol succinatePhase 2640

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C DeficiencyCompletedNCT00157118Phase 2, Phase 3
2Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot StudyCompletedNCT00732277Phase 2
3Sepsis-Associated Purpura Fulminans International Registry - EuropeRecruitingNCT02238795

Search NIH Clinical Center for Purpura Fulminans


Cochrane evidence based reviews: purpura fulminans

Genetic Tests for Purpura Fulminans

About this section

Anatomical Context for Purpura Fulminans

About this section

MalaCards organs/tissues related to Purpura Fulminans:

35
Skin, T cells, Liver, Brain, Bone

Animal Models for Purpura Fulminans or affiliated genes

About this section

MGI Mouse Phenotypes related to Purpura Fulminans:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5F2, F3, PROC, PROS1, SERPINC1
2MP:00053808.5F2, F3, PROCR, PROS1, SERPINC1
3MP:00053978.1F2, F3, PROC, PROCR, PROS1, SERPINC1
4MP:00053766.7F2, F3, PROC, PROCR, PROS1, SERPINC1

Publications for Purpura Fulminans

About this section

Articles related to Purpura Fulminans:

(show top 50)    (show all 416)
idTitleAuthorsYear
1
Infectious purpura fulminans. (25857509)
2015
2
Pravastatin-induced rhabdomyolysis and purpura fulminans in a patient with chronic renal failure. (25644555)
2015
3
Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. (23840047)
2013
4
Diagnosis and management of neonatal purpura fulminans. (21839696)
2011
5
Purpura fulminans: recognition, diagnosis and management. (21233082)
2011
6
Human skin allografts as a useful adjunct in the treatment of purpura fulminans. (20852508)
2010
7
Meningococcal purpura fulminans in children: I. Initial orthopedic management. (21966303)
2010
8
Purpura fulminans in meningococcal septicaemia in an adult: a case report. (21991197)
2010
9
Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. (20520582)
2010
10
Purpura fulminans: a cutaneous marker of disseminated intravascular coagulation. (19561767)
2009
11
Purpura fulminans: a case series managed at a regional burn center. (18354305)
2008
12
Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)
2007
13
Purpura fulminans: an unusual manifestation of severe falciparum malaria. (17588627)
2007
14
Safety and usefulness of invasive arterial blood pressure monitoring in purpura fulminans resuscitation. (17392648)
2007
15
Detection of Neisseria meningitidis DNA from skin lesion biopsy using real-time PCR: usefulness in the aetiological diagnosis of purpura fulminans. (17503017)
2007
16
Negative pressure dressing for promoting wound healing of purpura fulminans in a newborn with homozygous protein C deficiency. (17179832)
2007
17
Treatment of adult patients with sepsis-induced coagulopathy and purpura fulminans using a plasma-derived protein C concentrate (Ceprotin). (16635072)
2006
18
Capnocytophaga canimorsus sepsis with purpura fulminans and symmetrical gangrene following a dog bite in a shelter employee. (15201655)
2004
19
Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass. (15186640)
2004
20
Meningococcal purpura fulminans in a patient with systemic lupus erythematosus: a mimic for catastrophic antiphospholipid antibody syndrome? (15201656)
2004
21
Homozygous protein C deficiency with purpura fulminans: report of a new case and a description of a novel mutation. (12695756)
2003
22
A case report of purpura fulminans secondary to transient protein C deficiency as a complication of chickenpox infection. (12718382)
2003
23
Massive infectious soft-tissue injury: diagnosis and management of necrotizing fasciitis and purpura fulminans. (11252099)
2001
24
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
25
Postinfection purpura fulminans in a patient heterozygous for prothrombin G20210A and acquired protein S resistance. (10599098)
1999
26
Reconstructive surgery in children after meningococcal purpura fulminans. (10235331)
1999
27
Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans. (10632475)
1999
28
Protein-C concentrate for meningococcal purpura fulminans. (9734967)
1998
29
Compared contralateral application of topical nitroglycerin on purpura fulminans. (9505568)
1998
30
Homozygous Factor V Leiden mutation in a child with meningococcal purpura fulminans. (9469407)
1998
31
Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. (9393338)
1997
32
Management strategy in purpura fulminans with multiple organ failure in children. (8719318)
1996
33
Severe autoimmune protein S deficiency in a boy with idiopathic purpura fulminans. (7734361)
1995
34
Meningococcal purpura fulminans treated with antithrombin III concentrate: what is the optimal replacement therapy? (7848164)
1994
35
A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans. (7841324)
1994
36
Streptococcal gangrene and purpura fulminans. (1298264)
1992
37
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
38
Dermatopathology of skin necrosis associated with purpura fulminans. (2281318)
1990
39
Electrolyte changes caused by hydrotherapy in purpura fulminans. (3192606)
1988
40
Purpura fulminans in a case of protein C deficiency. (3366142)
1988
41
Purpura fulminans following late-onset group B beta-hemolytic streptococcal sepsis. (6383017)
1984
42
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
43
Purpura fulminans. (6461269)
1982
44
Purpura fulminans. (7112693)
1982
45
Purpura fulminans. (657839)
1978
46
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. (1147459)
1975
47
Purpura fulminans. (4936527)
1971
48
Purpura fulminans. (4873077)
1968
49
PURPURA FULMINANS. REPORT OF A CASE SUCCESSFULLY TREATED WITH HEPARIN AND HYDROCORTISONE. REVIEW OF 50 CASES FROM THE LITERATURE. (14214897)
1964
50
Purpura Fulminans. (19974790)
1910

Variations for Purpura Fulminans

About this section

Expression for genes affiliated with Purpura Fulminans

About this section
Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

About this section

Pathways related to Purpura Fulminans according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0F2, PROC, PROS1
29.0F2, PROC, PROS1
3
Show member pathways
8.5F2, PROC, PROCR, PROS1
4
Show member pathways
7.7F2, F3, PROC, PROS1, SERPINC1
5
Show member pathways
6.7F2, F3, PROC, PROCR, PROS1, SERPINC1
6
Show member pathways
6.7F2, F3, PROC, PROCR, PROS1, SERPINC1

GO Terms for genes affiliated with Purpura Fulminans

About this section

Cellular components related to Purpura Fulminans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.0PROS1, SERPINF2
2Golgi lumenGO:00057969.5F2, PROC, PROS1
3blood microparticleGO:00725628.4F2, PROS1, SERPINC1, SERPINF2
4extracellular regionGO:00055767.7F2, PROC, PROCR, PROS1, SERPINC1, SERPINF2
5extracellular spaceGO:00056157.3F2, F3, PROC, PROS1, SERPINC1, SERPINF2
6extracellular exosomeGO:00700627.1F2, F3, PROCR, PROS1, SERPINC1, SERPINF2

Biological processes related to Purpura Fulminans according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of coagulationGO:005081910.3PROC, PROCR
2negative regulation of fibrinolysisGO:00519189.8F2, SERPINF2
3positive regulation of collagen biosynthetic processGO:00329679.8F2, SERPINF2
4acute-phase responseGO:00069539.8F2, SERPINF2
5peptidyl-glutamic acid carboxylationGO:00171879.5F2, PROC, PROS1
6signal peptide processingGO:00064659.4F2, PROC, PROS1
7negative regulation of endopeptidase activityGO:00109519.3PROS1, SERPINC1, SERPINF2
8fibrinolysisGO:00427309.2F2, PROS1, SERPINF2
9ER to Golgi vesicle-mediated transportGO:00068889.1F2, PROC, PROS1
10leukocyte migrationGO:00509008.2F2, PROC, PROCR, PROS1
11blood coagulationGO:00075967.3F2, F3, PROC, PROCR, PROS1, SERPINC1

Molecular functions related to Purpura Fulminans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.6PROS1, SERPINF2
2protease bindingGO:00020208.7F3, SERPINC1, SERPINF2
3serine-type endopeptidase activityGO:00042528.5F2, F3, PROC

Sources for Purpura Fulminans

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet