MCID: PRP034
MIFTS: 42

Purpura Fulminans malady

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Purpura Fulminans

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Summaries for Purpura Fulminans

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Disease Ontology:11 A purpura characterized blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. It is often fatal.

MalaCards based summary: Purpura Fulminans, also known as purpura gangrenosa, is related to thrombophilia and acquired purpura fulminans, and has symptoms including cullen's sign and mucocutaneous haemorrhage. An important gene associated with Purpura Fulminans is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are cardiovascular system and embryo.

Wikipedia:71 Purpura fulminans (also known as \"Purpura gangrenosa\") is an acute, often fatal, thrombotic disorder... more...

Related Diseases for Purpura Fulminans

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Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia29.7F2, SERPINC1
2acquired purpura fulminans12.2
3thrombophilia due to protein c deficiency, autosomal recessive11.2
4thrombophilia due to protein s deficiency, autosomal recessive11.2
5purpura11.0
6protein c deficiency10.4
7catatrichy10.3F3, PROC
8familial glomangioma10.3F2, F3
9protein s deficiency10.3
10cerebral angioma10.3F2, F3
11dislocation of ear ossicle10.3F2, F3
12von willibrand disease, type 310.3F2, F3
13epididymo-orchitis10.3F2, F3
14chorea gravidarum10.3F2, F3
15central nervous system germinoma10.2F2, F3
16congenital nystagmus10.2F2, F3
17peroneal neuropathy10.2F2, F3
18splenic infarction10.2F2, F3
19wfs1-related disorders10.2F2, F3
20pneumonia10.2
21meningococcemia10.2
22facioscapulohumeral muscular dystrophy 110.2F2, F3
23cercarial dermatitis10.2F2, F3
24disseminated intravascular coagulation10.2
25idiopathic central precocious puberty10.2F2, F3
26subcortical arteriosclerotic encephalopathy10.2F2, SERPINC1
27artery disease10.2F2, F3
28infantile-onset ascending hereditary spastic paralysis10.2F2, F3
29factor x deficiency10.2F2, F3
30collagenous colitis10.2F2, SERPINC1
31hypertensive heart disease10.2F2, SERPINC1
32spleen cancer10.2F2, SERPINC1
33thrombophilia due to thrombin defect10.2F2, SERPINC1
34posterolateral myocardial infarction10.2F2, SERPINC1
35thrombocytopenia with elevated serum iga and renal disease10.2F2, F3
36may-hegglin anomaly10.2F2, SERPINC1
37left-right axis malformations10.1F2, SERPINC1
38scapuloperoneal myopathy, x-linked dominant10.1F2, F3
39polyhydramnios10.1F2, SERPINC1
40meningitis10.1
41histoplasmosis10.1F2, SERPINC1
42cavernous sinus thrombosis10.1F3, SERPINC1
43hepatic fibrosis renal cysts mental retardation10.1F3, SERPINC1
44budd-chiari syndrome10.1F2, SERPINC1
45selective iga deficiency disease10.1F2, SERPINC1
46hepatic coma10.1F2, F3
47chickenpox10.1
48anterior foramen magnum meningioma10.1F2, SERPINC1
49apocrine adenoma10.1F2, F3
50joint disorders10.1F2, SERPINC1

Graphical network of the top 20 diseases related to Purpura Fulminans:



Diseases related to purpura fulminans

Symptoms & Phenotypes for Purpura Fulminans

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UMLS symptoms related to Purpura Fulminans:


cullen's sign, mucocutaneous haemorrhage

MGI Mouse Phenotypes related to Purpura Fulminans according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5F2, F3, PROC, PROS1, SERPINC1
2MP:00053808.5F2, F3, PROCR, PROS1, SERPINC1
3MP:00053978.1F2, F3, PROC, PROCR, PROS1, SERPINC1
4MP:00053766.7F2, F3, PROC, PROCR, PROS1, SERPINC1

Drugs & Therapeutics for Purpura Fulminans

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Drugs for Purpura Fulminans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Protein CPhase 2, Phase 3115
2Fibrinolytic AgentsPhase 2, Phase 32317
3AnticoagulantsPhase 2, Phase 32516
4
Hydrocortisoneapproved, vet_approvedPhase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11╬▓-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
5
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
6Hydrocortisone-17-butyratePhase 2318
7Hydrocortisone acetatePhase 2640
8Hydrocortisone 17-butyrate 21-propionatePhase 2640
9Anti-Inflammatory AgentsPhase 210355
10Cortisol succinatePhase 2640

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C DeficiencyCompletedNCT00157118Phase 2, Phase 3
2Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot StudyCompletedNCT00732277Phase 2
3Sepsis-Associated Purpura Fulminans International Registry - EuropeRecruitingNCT02238795

Search NIH Clinical Center for Purpura Fulminans


Cochrane evidence based reviews: purpura fulminans

Genetic Tests for Purpura Fulminans

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Anatomical Context for Purpura Fulminans

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MalaCards organs/tissues related to Purpura Fulminans:

36
Skin, T cells, Liver, Brain, Bone

Publications for Purpura Fulminans

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Articles related to Purpura Fulminans:

(show top 50)    (show all 416)
idTitleAuthorsYear
1
Purpura Fulminans Associated with Overwhelming Postsplenectomy Infection. (28090064)
2017
2
Successful Corticosteroid Treatment for Purpura Fulminans Associated with Quinolone. (27746448)
2016
3
A Novel Protein C Mutation Causing Neonatal Purpura Fulminans. (27889735)
2016
4
Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult. (27583208)
2016
5
Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. (27052576)
2016
6
Challenging Airway Secondary to Purpura Fulminans With Face and Neck Bullae in a Premature Infant. (27941484)
2016
7
Purpura fulminans secondary to rickettsial infections: A case series. (26955583)
2016
8
Streptococcus pneumoniae-induced purpura fulminans. (27083982)
2016
9
Acute infectious purpura fulminans caused by group A I^-hemolytic Streptococcus: An uncommon organism. (27057503)
2016
10
Lifetime cost of meningococcal disease in France: Scenarios of severe meningitis and septicemia with purpura fulminans. (26688376)
2016
11
Pneumococcal Sepsis Complicated by Splenic Abscesses and Purpura Fulminans in a 15-Month-Old Child: Case Report and Review of the Literature. (27006958)
2016
12
Purpura fulminans associated with acute West Nile virus encephalitis. (26686320)
2016
13
Severe Neonatal Purpura Fulminans Caused by Staphylococcus aureus. (27449990)
2016
14
Purpura fulminans related to paroxysmal nocturnal haemoglobinuria. (27046923)
2016
15
Strongyloides stercoralis hyperinfection in patient with autoimmune hepatitis and purpura fulminans. (26955218)
2016
16
Purpura fulminans and severe sepsis due to Pasteurella multocida infection in an immunocompetent patient. (27298290)
2016
17
Infectious purpura fulminans. (25857509)
2015
18
Pravastatin-induced rhabdomyolysis and purpura fulminans in a patient with chronic renal failure. (25644555)
2015
19
Purpura Fulminans due to Enterobacter cloacae. (26370876)
2015
20
Purpura fulminans in the setting of Escherichia coli septicemia. (26761941)
2015
21
Purpura Fulminans Due to Acquired Protein C Deficiency. (26677306)
2015
22
Neonatal purpura fulminans due to protein C deficiency. (25783192)
2015
23
Purpura Fulminans Secondary to Rickettsial Infection: A Case Report. (26673422)
2015
24
Angioimmunoblastic t-cell lymphoma presenting as purpura fulminans. (25750965)
2015
25
1102: PROTEIN C FOR TREATMENT OF SEPSIS ASSOCIATED PURPURA FULMINANS. (26570763)
2015
26
Bilateral symmetrical digital gangrene of upper and lower limbs due to purpura fulminans caused by Streptococcus pyogenes: A rare entity. (25983440)
2015
27
Skin Necrosis and Purpura Fulminans in Children With and Without Thrombophilia-A Tertiary Center's Experience. (26436558)
2015
28
Purpura fulminans 10 years after contaminated cocaine use. (26028121)
2015
29
From the toe to the head: metastatic endophalmitis following staphylococcal purpura fulminans. (24231686)
2014
30
Fatal purpura fulminans and septic shock in asplenic patient with Streptococcus pneumoniae bacteremia. (24407746)
2014
31
Indian tick typhus presenting as Purpura fulminans. (25097365)
2014
32
Identification of differentially expressed serum proteins in infectious purpura fulminans. (24659849)
2014
33
Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. (23840047)
2013
34
Meningococcal sepsis and purpura fulminans: the surgical perspective. (23389283)
2013
35
Limb fitting for quadruple amputees: report of two cases of symmetrical peripheral gangrene caused by pneumococcal purpura fulminans. (23558402)
2013
36
Plastic surgical treatment of purpura fulminans: Long-term follow-up of two patients. (23210495)
2013
37
Purpura fulminans associated with Streptococcus pneumoniae septicemia in an asplenic pediatric patient. (23985086)
2013
38
Pneumococcal sepsis-induced purpura fulminans in an asplenic adult patient without disseminated intravascular coagulation. (24185261)
2013
39
Purpura Fulminans after Therapeutic Hypothermia in an Asphyxiated Neonate with Streptococcemia. (23839905)
2013
40
Purpura fulminans in a patient with mixed connective tissue disease. (23370948)
2013
41
Neonatal purpura fulminans manifestation in early-onset group B Streptococcal infection. (23970945)
2013
42
A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans. (24158118)
2013
43
Two cases of meningococcal purpura fulminans: the 'less is more' approach. (23323934)
2013
44
Purpura fulminans caused by meningococcemia in an infant. (23921694)
2013
45
Purpura fulminans in a patient with paroxysmal nocturnal haemoglobinuria. (23324094)
2013
46
Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans. (23924269)
2013
47
Antiphospholipid antibody syndrome presenting with purpura fulminans. (23869929)
2013
48
Streptococcus pneumoniae-induced purpura fulminans in a woman with functional asplenia. (23870635)
2013
49
Toxic shock syndrome due to group A beta-hemolytic streptococcus presenting with purpura fulminans and limb ischemia in a pediatric patient treated with early microsurgical arteriolysis. (23331831)
2013
50
Purpura fulminans in an acute preterm neonate. (23250966)
2013

Variations for Purpura Fulminans

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Expression for genes affiliated with Purpura Fulminans

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Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

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Pathways related to Purpura Fulminans according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0F2, PROC, PROS1
29.0F2, PROC, PROS1
3
Show member pathways
8.5F2, PROC, PROCR, PROS1
4
Show member pathways
7.7F2, F3, PROC, PROS1, SERPINC1
5
Show member pathways
6.7F2, F3, PROC, PROCR, PROS1, SERPINC1
6
Show member pathways
6.7F2, F3, PROC, PROCR, PROS1, SERPINC1

GO Terms for genes affiliated with Purpura Fulminans

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Cellular components related to Purpura Fulminans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.4F2, PROC, PROS1
2platelet alpha granule lumenGO:00310939.3PROS1, SERPINF2
3blood microparticleGO:00725629.2F2, PROS1, SERPINC1, SERPINF2
4extracellular regionGO:00055768.3F2, PROC, PROCR, PROS1, SERPINC1, SERPINF2
5extracellular exosomeGO:00700627.9F2, F3, PROCR, PROS1, SERPINC1, SERPINF2
6extracellular spaceGO:00056157.8F2, F3, PROC, PROS1, SERPINC1, SERPINF2

Biological processes related to Purpura Fulminans according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of coagulationGO:005081910.2PROC, PROCR
2acute-phase responseGO:000695310.1F2, SERPINF2
3negative regulation of fibrinolysisGO:00519189.9F2, SERPINF2
4positive regulation of collagen biosynthetic processGO:00329679.8F2, SERPINF2
5ER to Golgi vesicle-mediated transportGO:00068889.6F2, PROC, PROS1
6fibrinolysisGO:00427309.4F2, PROS1, SERPINF2
7negative regulation of endopeptidase activityGO:00109519.4PROS1, SERPINC1, SERPINF2
8peptidyl-glutamic acid carboxylationGO:00171879.4F2, PROC, PROS1
9leukocyte migrationGO:00509009.1F2, PROC, PROCR, PROS1
10signal peptide processingGO:00064659.0F2, PROC, PROS1
11blood coagulationGO:00075967.9F2, F3, PROC, PROCR, PROS1, SERPINC1

Molecular functions related to Purpura Fulminans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:000486610.0PROS1, SERPINF2
2protease bindingGO:00020209.3F3, SERPINC1, SERPINF2
3serine-type endopeptidase activityGO:00042528.8F2, F3, PROC

Sources for Purpura Fulminans

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet