Purpura Fulminans disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Purpura Fulminans

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Purpura fulminans (also known as \"Purpura gangrenosa\") is an acute, often fatal, thrombotic disorder... more...

MalaCards: Purpura Fulminans is related to purpura and protein c deficiency. An important gene associated with Purpura Fulminans is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are PTM: gamma carboxylation, hypusine formation and arylsulfatase activation and Platelet activation, signaling and aggregation. The compounds serine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are nervous system and hematopoietic system.

Aliases & Classifications for Purpura Fulminans

Sources:
⁴⁸Orphanet, ⁶⁰UMLS, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases

ICD10: ²⁶

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Coagulation defects, purpura and other haemorrhagic conditions

Disseminated intravascular coagulation [defibrination syndrome]

Aliases & Descriptions:

purpura fulminans ⁴⁸ ⁶⁰

External Ids:

SNOMED-CT via Orphanet⁵⁷ 13507004

UMLS via Orphanet⁶¹ C0043068, C0085650

MESH via Orphanet³⁵ D014884, D055665

ICD10 via Orphanet²⁶ D65

Related Diseases for Purpura Fulminans

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 161)

id	Related Disease	Score	Top Affiliating Genes
1	purpura	32.1	SERPINC1
2	protein c deficiency	31.2	SERPINC1, F2, PROC, PROCR, MTHFR, F5
3	protein s deficiency	31.0	APOH, F5, MTHFR, F3, F2, SERPINC1
4	disseminated intravascular coagulation	30.9	F5, PROC, F3, F2, PLAT, SERPINC1
5	pneumonia	30.8	LACTB, CSF3
6	meningitis	30.7	LACTB
7	influenza	30.5	LACTB
8	factor v deficiency	30.5	F5, F3, F2
9	lupus erythematosus	30.4	C1S, APOH, F5, PROCR, F3, F2
10	arthritis	30.3	LACTB
11	systemic lupus erythematosus	30.3	C1S, APOH, PROCR, F3, F2
12	leukemia	30.3	LACTB, MTHFR, CSF3
13	antiphospholipid syndrome	30.3	SERPINC1, PLAT, F2, F3, PROCR, MTHFR
14	hepatitis a	30.1	F2
15	hepatitis	30.1	F2
16	endocarditis	30.1	LACTB
17	toxic shock syndrome	30.1	LACTB
18	ischemia	30.1	C1S, PLAT
19	multiple myeloma	30.1	CSF3
20	myeloma	30.1	CSF3
21	angioedema	30.1	C1S, PLAT
22	peritonitis	30.1	LACTB, F2
23	endophthalmitis	30.1	LACTB, PLAT
24	vasculitis	30.1	C1S, APOH, F2
25	galactosemia	30.1	F3, F2, SERPINC1
26	rheumatoid arthritis	30.1	C1S, APOH, MTHFR
27	hemolytic anemia	30.1	APOH, F3, LACTB
28	factor vii deficiency	30.1	F5, F3, F2, SERPINC1
29	connective tissue disease	30.1	C1S, APOH, F3, F2
30	antithrombin iii deficiency	30.1	SERPINC1, F2, MTHFR, F5, APOH
31	chickenpox	10.5
32	burns	10.4
33	malaria	10.4
34	necrotizing fasciitis	10.3
35	scarlet fever	10.3
36	fasciitis	10.3
37	osteonecrosis	10.1
38	hereditary angioedema	10.1
39	subdural empyema	10.1
40	mixed connective tissue disease	10.1
41	stevens-johnson syndrome	10.1
42	dengue hemorrhagic fever	10.1
43	polyarteritis nodosa	10.1
44	thrombotic thrombocytopenic purpura	10.1
45	ulcerative colitis	10.1
46	measles	10.1
47	streptococcal meningitis	10.1
48	churg-strauss syndrome	10.1
49	adult syndrome	10.1
50	cryptococcosis	10.1

Graphical network of the top 20 diseases related to Purpura Fulminans:

Clinical Features for Purpura Fulminans

Drugs & Therapeutics for Purpura Fulminans

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Purpura Fulminans

Drug clinical trials:

Search ClinicalTrials for Purpura Fulminans

Search NIH Clinical Center for Purpura Fulminans

Search CenterWatch for Purpura Fulminans

Genetic Tests for Purpura Fulminans

Anatomical Context for Purpura Fulminans

Sources:
³²MalaCards
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MalaCards organs/tissues related to Purpura Fulminans:

³²

Skin

Animal Models for Purpura Fulminans or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Purpura Fulminans:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	7.6	F2, SERPINC1, F5, MTHFR, PROC, F3
2	hematopoietic system phenotype	MP:0005397	7.3	CSF3, PROCR, PROC, F2, PLAT, SERPINC1
3	immune system phenotype	MP:0005387	7.1	SERPINC1, F2, F3, PROC, PROCR, PLAT
4	homeostasis/metabolism phenotype	MP:0005376	7.0	APOH, SERPINC1, PLAT, F2, F3, PROC
5	mortality/aging	MP:0010768	6.9	SERPINC1, APOH, F5, PROCR, PROC, F3

Publications for Purpura Fulminans

Genes related to Purpura Fulminans

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Purpura Fulminans:

(show all 12)

id	Symbol	Description	Score	Implication
1	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	21.04	GeneCards inferred : Publications, Disorders, Summaries (show sections)
2	F5	coagulation factor V (proaccelerin, labile factor)	19.22	GeneCards inferred : Publications, Disorders (show sections)
3	PROCR	protein C receptor, endothelial	17.56	GeneCards inferred : Disorders (show sections)
4	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	15.89	GeneCards inferred : Publications, Disorders (show sections)
5	C1S	complement component 1, s subcomponent	14.18	GeneCards inferred : Publications, Disorders (show sections)
6	APOH	apolipoprotein H (beta-2-glycoprotein I)	12.51	GeneCards inferred : Publications, Disorders (show sections)
7	F2	coagulation factor II (thrombin)	10.85	GeneCards inferred : Publications, Disorders (show sections)
8	F3	coagulation factor III (thromboplastin, tissue factor)	9.18	GeneCards inferred : Publications, Disorders (show sections)
9	PLAT	plasminogen activator, tissue	7.51	GeneCards inferred : Publications, Disorders (show sections)
10	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	5.85	GeneCards inferred : Publications, Disorders (show sections)
11	CSF3	colony stimulating factor 3 (granulocyte)	4.18	GeneCards inferred : Publications, Disorders (show sections)
12	LACTB	lactamase, beta	1.69	GeneCards inferred : Publications (show sections)

Products for genes related to Purpura Fulminans disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	12	12	12
2	LSBio	-	-	12

Genetic Variations for Purpura Fulminans

Expression for genes affiliated with Purpura Fulminans

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura Fulminans

Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

Sources:
⁵³Reactome, ⁴⁹PharmGKB, ³⁷NCBI BioSystems Database, ⁵¹QIAGEN, ⁵²R&D Systems, ²⁹KEGG
See all sources

Pathways related to Purpura Fulminans according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation⁵³	9.8	PROC, F2
2	Platelet activation, signaling and aggregation⁵³ Hide members Hemostasis⁵³	9.6	F3, F2
3	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins⁵³ Hide members Removal of aminoterminal propeptides from gamma-carboxylated proteins⁵³ Warfarin Pathway, Pharmacodynamics⁴⁹ Gamma-carboxylation of protein precursors⁵³ Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus⁵³	9.3	F3, F2, PROC
4	Selenium Pathway³⁷	8.9	MTHFR, F2, PLAT
5	Collagen biosynthesis and modifying enzymes⁵³ Hide members Blood Coagulation Cascade⁵¹ Intrinsic Prothrombin Activation Pathway⁵¹	8.7	F3, SERPINC1, F2, PROC, F5
6	Common Pathway⁵³ Hide members Extrinsic Prothrombin Activation Pathway⁵¹	8.7	SERPINC1, F2, F3, PROC, F5
7	Formation of Fibrin Clot (Clotting Cascade)⁵³ Hide members Blood Coagulation Signaling Pathways⁵² Blood Clotting Cascade³⁷ Intrinsic Pathway⁵³	8.2	PROC, F3, F2, F5, PLAT, SERPINC1
8	Complement and coagulation cascades²⁹ Hide members Complement and Coagulation Cascades³⁷	7.9	PROC, F5, F3, F2, PLAT, SERPINC1

Compounds for genes affiliated with Purpura Fulminans

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ¹¹DrugBank, ²⁴HMDB, ²⁸IUPHAR, ²BitterDB, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Purpura Fulminans according to GeneCards/GeneDecks:

(show top 50) (show all 140)

id	Compound	Score	Top Affiliating Genes
1	serine⁴⁴	10.0	PROCR, LACTB
2	coumarins⁴⁴	10.0	APOH, F3
3	warfarin⁴⁴ ⁴⁹ ¹¹ ²⁴	13.0	APOH, PROC, SERPINC1
4	hirugen⁴⁴	9.6	F5, F2, SERPINC1
5	certoparin⁴⁴	9.6	F3, F2, SERPINC1
6	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.6	MTHFR, APOH, C1S
7	reviparin⁴⁴	9.4	F3, PLAT, SERPINC1
8	inogatran⁴⁴	9.4	F5, F3, F2, SERPINC1
9	ecarin⁴⁴	9.4	F5, F3, F2, SERPINC1
10	efegatran⁴⁴	9.4	F3, PLAT, SERPINC1
11	danaparoid⁴⁴	9.4	SERPINC1, F2, F3, F5
12	ximelagatran⁴⁴ ¹¹	10.4	F5, F3, F2, SERPINC1
13	heparinoids⁴⁴	9.4	F5, F3, F2, SERPINC1
14	kaolin⁴⁴	9.3	F2, F3, F5, APOH
15	heparin sodium⁴⁴	9.3	F3, F2, PLAT
16	ancrod⁴⁴	9.3	F5, F2, PLAT, SERPINC1
17	polybrene⁴⁴	9.3	F3, F2, SERPINC1
18	hepaplastin⁴⁴	9.3	SERPINC1, F2, F3
19	dextran 70⁴⁴	9.2	F3, F2, PLAT
20	gamma-carboxyglutamic acid⁴⁴	9.2	F5, PROCR, PROC, F3, F2
21	coumarin⁴⁴ ² ⁴⁹ ²⁴	12.1	F5, F3, F2, SERPINC1
22	ppack⁴⁴	9.1	F3, F2, PLAT, SERPINC1
23	tirofiban⁴⁴ ¹¹	10.1	SERPINC1, PLAT, F2, F3
24	epsilon aminocaproic acid⁴⁴	9.1	F3, F2, PLAT, SERPINC1
25	ticlopidine⁴⁴ ¹¹	10.1	APOH, F3, PLAT, SERPINC1
26	aprotinin⁴⁴ ¹¹	10.0	SERPINC1, PLAT, F3, F5, C1S
27	spectrozyme⁴⁴	8.9	SERPINC1, PLAT, F2, F3, F5
28	fondaparinux⁴⁴	8.9	F5, F3, F2, PLAT, SERPINC1
29	bivalirudin⁴⁴ ¹¹	9.9	F5, F3, F2, PLAT, SERPINC1
30	argatroban⁴⁴ ¹¹	9.9	F5, F3, F2, PLAT, SERPINC1
31	protamine sulfate⁴⁴	8.9	F5, F3, F2, PLAT, SERPINC1
32	ristocetin⁴⁴	8.9	SERPINC1, PLAT, F2, F3, F5
33	levonorgestrel⁴⁴ ⁵⁹ ²⁸ ¹¹	11.9	F5, F3, F2, PLAT, SERPINC1
34	desmopressin⁴⁴ ⁵⁹ ²⁸ ¹¹	11.9	F5, F3, F2, PLAT, SERPINC1
35	protamine⁴⁴	8.8	SERPINC1, PLAT, F2, F3, F5
36	tranexamic acid⁴⁴ ¹¹	9.8	PLAT, F2, F3, C1S, SERPINC1
37	clopidogrel⁴⁹ ⁴⁴ ¹¹ ²⁴	11.8	F3, F2, PLAT, SERPINC1
38	dermatan sulfate⁴⁴	8.8	F5, F3, F2, PLAT, SERPINC1
39	abciximab⁴⁴ ¹¹	9.8	C1S, F3, F2, PLAT, SERPINC1
40	hydroxyethyl starch⁴⁴	8.8	CSF3, F3, F2, SERPINC1
41	phosphatidylethanolamine⁴⁴ ¹¹	9.8	APOH, F5, PROCR, F2
42	hirudin⁴⁴	8.6	F5, PROCR, F3, F2, PLAT, SERPINC1
43	phospholipid⁴⁴	8.6	APOH, F5, PROCR, PROC, F3, F2
44	prostacyclin⁴⁴	8.5	C1S, APOH, F5, F3, PLAT, SERPINC1
45	kininogen⁴⁴	8.2	C1S, APOH, SERPINC1, PLAT, F2, F3
46	homocysteine⁴⁴ ²⁴	8.9	APOH, F5, MTHFR, F3, F2, PLAT
47	cyclophosphamide⁴⁴ ⁴⁹ ¹¹	9.8	F3, MTHFR, F5, APOH, CSF3
48	creatinine⁴⁴	7.8	APOH, F5, MTHFR, F3, F2, PLAT
49	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	10.6	C1S, APOH, F5, MTHFR, F3, F2
50	fibrinogen⁴⁴	7.0	SERPINC1, C1S, APOH, F5, MTHFR, PROCR

GO Terms for genes affiliated with Purpura Fulminans

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Purpura Fulminans according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.1	PLAT, F3, APOH
2	extracellular region	GO:005576	8.0	C1S, F5, PROC, F2, PLAT, SERPINC1
3	extracellular space	GO:005615	7.2	SERPINC1, CSF3, APOH, F5, F3, F2

Biological processes related to Purpura Fulminans according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-glutamic acid carboxylation	GO:017187	9.9	PROC, F2
2	negative regulation of blood coagulation	GO:030195	9.9	PROC, APOH
3	negative regulation of fibrinolysis	GO:051918	9.9	APOH, F2
4	positive regulation of blood coagulation	GO:030194	9.8	APOH, F2
5	plasminogen activation	GO:031639	9.8	APOH, PLAT
6	fibrinolysis	GO:042730	9.5	F2, PLAT
7	negative regulation of proteolysis	GO:045861	9.4	F2, PLAT
8	blood coagulation, intrinsic pathway	GO:007597	9.4	F2, APOH
9	proteolysis	GO:006508	8.9	F2, PROC, C1S, PLAT
10	blood coagulation	GO:007596	8.1	F3, F5, SERPINC1, PLAT, F2, PROCR