Purpura Fulminans disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology:¹¹ A purpura characterized blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. It is often fatal.

MalaCards based summary: Purpura Fulminans, also known as purpura gangrenosa, is related to lupus erythematosus and influenza. An important gene associated with Purpura Fulminans is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways are Warfarin Pathway, Pharmacodynamics and Cell surface interactions at the vascular wall. Affiliated tissues include skin, t cells and breast, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:⁷¹ Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising... more...

Related Diseases for Purpura Fulminans

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)

id	Related Disease	Score	Top Affiliating Genes
1	lupus erythematosus	29.9	F3, SERPINC1
2	influenza	29.3	F2, F3, SERPINC1, SERPINF2
3	acquired purpura fulminans	12.2
4	thrombophilia due to protein c deficiency, autosomal recessive	11.2
5	thrombophilia due to protein s deficiency, autosomal recessive	11.2
6	purpura	11.0
7	protein c deficiency	10.4
8	protein s deficiency	10.3
9	pneumonia	10.2
10	meningococcemia	10.2
11	disseminated intravascular coagulation	10.2
12	hemarthrosis	10.2	F2, F3
13	central congenital hypothyroidism	10.2	F3, PROC
14	alpha-2-macroglobulin deficiency	10.2	F2, F3
15	hendra virus infection	10.2	F2, F3
16	prostatic hypertrophy	10.2	F2, F3
17	dyskinetic cerebral palsy	10.2	F2, F3
18	stroke, ischemic	10.2	F2, F3
19	sporotrichosis	10.2	F2, F3
20	chronic inflammatory demyelinating polyneuritis	10.2	F2, F3
21	seminoma	10.2	F2, F3
22	brain stem cancer	10.1	F2, F3
23	fletcher factor deficiency	10.1	F2, F3
24	myotonic dystrophy	10.1	F2, F3
25	meningitis	10.1
26	vascular erectile tumor	10.1	F2, SERPINC1
27	spinocerebellar ataxia 27	10.1	F2, F3
28	may-hegglin anomaly	10.1	F2, SERPINC1
29	mobitz type ii atrioventricular block	10.1	F2, F3
30	retinal arterial macroaneurysm with supravalvular pulmonic stenosis	10.1	F2, F3
31	left-right axis malformations	10.1	F2, SERPINC1
32	lymphocytic colitis	10.1	F2, SERPINC1
33	schwannoma of jugular foramen	10.1	F2, SERPINC1
34	artery disease	10.1	F2, F3
35	bullous skin disease	10.1	F2, SERPINC1
36	red color blindness	10.1	F2, F3
37	neuroaxonal dystrophy	10.1	F2, SERPINC1
38	cerebellar astrocytoma	10.1	F2, SERPINC1
39	periosteal chondrosarcoma	10.1	F2, SERPINC1
40	chickenpox	10.1
41	angelucci's syndrome	10.1	F2, SERPINC1
42	sertoli cell tumor	10.1	F3, SERPINC1
43	hereditary endotheliopathy, retinopathy, nephropathy, and stroke	10.1	F3, SERPINC1
44	low anorectal malformation	10.1	F2, F3
45	hypertrichosis	10.1	F3, SERPINC1
46	cryptosporidiosis	10.1	F2, SERPINC1
47	angular blepharoconjunctivitis	10.1	F2, SERPINC1
48	otopalatodigital syndrome, type i	10.1	F2, F3
49	ovarian papillary cystadenoma	10.1	F2, SERPINC1
50	eagle syndrome	10.1	F2, SERPINC1

Graphical network of the top 20 diseases related to Purpura Fulminans:

Symptoms & Phenotypes for Purpura Fulminans

Sources:
⁴¹MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Purpura Fulminans according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	8.5	F2, F3, PROC, PROCR, SERPINC1
2	hematopoietic system	MP:0005397	8.5	F2, F3, PROC, PROCR, SERPINC1
3	homeostasis/metabolism	MP:0005376	7.9	F2, F3, PROC, PROCR, SERPINC1, SERPINF2
4	immune system	MP:0005387	7.6	F2, F3, PROC, PROCR, SERPINC1

Drugs & Therapeutics for Purpura Fulminans

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Purpura Fulminans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Protein C

Phase 2, Phase 3

118

2

Fibrinolytic Agents

Phase 2, Phase 3

2388

3

Anticoagulants

Phase 2, Phase 3

2623

4

Hydrocortisone

approved, vet_approved

Phase 2

667

50-23-7

5754, 657311

Synonyms:

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

11-Hydrocortisone

11-beta-Hydrocortisone

11-beta-Hydroxycortisone

11a-Hydroxycorticosterone

11alpha-Hydroxycorticosterone

11b,17,21-Trihydroxyprogesterone

11b-Hydrocortisone

11b-Hydroxycortisone

11beta,17,21-Trihydroxyprogesterone

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

11beta-Hydrocortisone

11beta-Hydroxycortisone

11beta-hydrocortisone

11β-hydrocortisone

17-Hydroxycorticosterone

17a-Hydroxycorticosterone

17alpha-Hydroxycorticosterone

2v95

4-Pregnen-11beta,17alpha,21-triol-3,20-dione

4-Pregnene-11alpha,21-triol 3,20-dione

4-Pregnene-11b,17a,21-triol-3,20-dione

50-23-7

8056-08-4

80562-38-5

8063-42-1

AC-12902

AC1L1L2B

ACETASOL HC

ACETIC ACID W/ HYDROCORTISONE

AI3-25006

AKOS001582651

Acticort

Acticort (TN)

Aeroseb HC

Aeroseb-HC

Ala-Cort

Ala-Scalp

Alacort

Algicirtis

Alphaderm

Amberin

Anflam

Anti-inflammatory hormone

Anucort

Anucort-HC

Anusol HC

Anusol HC (TN)

Aquacort

Aquanil HC

B48448A1-24BA-47CA-8D9E-43E5BC949386

BPBio1_000544

BRD-K93568044-001-03-1

BSPBio_000494

Balneol-hc

Barseb HC

Basan-Corti

Beta-hc

Bio-0648

C00735

C21H30O5

CCRIS 5854

CHEBI:17650

CHEMBL389621

CID5754

COR-OTICIN

CPD000653523

CaldeCORT Spray

Cetacort

Chronocort

Clear aid

Cleiton

Cobadex

Colocort

Colocort (TN)

Compound F

Compound F (kendall)

Cor-Tar-Quin

Corhydron

Cort-Dome

Cort-Quin

Cortanal

Cortef

Cortef (TN)

Cortenema

Cortesal

Corticreme

Cortifair

Cortifan

Cortifoam

Cortiment

Cortisol

Cortisol alcohol

Cortisol, Hydrocortisone

Cortisolonum

Cortisporin

Cortisporin Otico

Cortispray

Cortizol

Cortolotion

Cortonema

Cortoxide

Cortril

Cremesone

Cremicort-H

Cutisol

Cyclodextrin-encapsulated hydrocortisone

D00088

DB00741

DB07886

Delacort

Derm-Aid

Dermacort

Dermaspray

Dermil

Dermocortal

Dermolate

Dihydrocostisone

Dioderm

Dome-cort

Domolene-HC

Drotic

DuoCort

EINECS 200-020-1

EU-0100594

Ef corlin

Efcorbin

Efcortelan

Efcortelin

Eldecort

Eldercort

Epicort

Epicortisol

Epiderm H

Esiderm H

Evacort

Ficortril

Fiocortril

Flexicort

Foille Insetti

Genacort

Genacort (lotion)

Glycort

Gyno-Cortisone

H 4001

H-Cort

H0135_SIGMA

H0396_SIGMA

H0888_SIGMA

H3160_SIGMA

H4001_SIGMA

H6909_SIGMA

HC

HC #1

HC #4

HC (HYDROCORTISONE)

HMS1569I16

HMS2090M04

HSDB 3339

HYDROCORTISONE AND ACETIC ACID

HYDROCORTISONE IN ABSORBASE

Heb Cort

Heb-Cort

Hi-cor

Hidalone

Hidro-Colisona

Hidrocortisona

Hidrocortisona [INN-Spanish]

Hycort

Hycortol

Hycortole

Hydracort

Hydrasson

Hydro-Adreson

Hydro-Colisona

Hydro-RX

Hydro-colisona

Hydrocort

Hydrocortal

Hydrocorticosterone

Hydrocortisone

Hydrocortisone (JP15/USP/INN)

Hydrocortisone Acetate

Hydrocortisone Base

Hydrocortisone Butyrate

Hydrocortisone Sodium Phosphate

Hydrocortisone Valerate

Hydrocortisone [INN:BAN:JAN]

Hydrocortisone alcohol

Hydrocortisone base

Hydrocortisone free alcohol

Hydrocortisone solution

Hydrocortisone-Water Soluble

Hydrocortisonum

Hydrocortisonum [INN-Latin]

Hydrocortistab

Hydrocortisyl

Hydrocortone

Hydroskin

Hydroxycortisone

Hysone

Hytisone

Hytone

Hytone (TN)

Hytone lotion

Idrocortisone

Idrocortisone [DCIT]

Incortin-H

Incortin-hydrogen

Kendall'S compound F

Kendall's compound F

Komed HC

Kyypakkaus

LMST02030001

LS-7439

Lacticare HC

Lacticare-HC

Lactisona

Lopac0_000594

Lubricort

MLS000069609

MLS001148103

MLS002207135

MLS002222189

Maintasone

Medicort

Meusicort

Mildison

Milliderm

MolPort-001-794-637

NCGC00022848-06

NCGC00022848-07

NCGC00022848-09

NCGC00022848-12

NCI60_000118

NSC 10483

NSC-10483

NSC10483

Neo-Cort-Dome

Neo-Cortef

Neosporin-H Ear

Nogenic HC

Nutracort

Nystaform-HC

ORLEX HC

Optef

Otalgine

Otic-Neo-Cort-Dome

Otobiotic

Otocort

Otosone-F

Pediotic Suspension

Penecort

Permicort

Polcort H

Preparation H Hydrocortisone Cream

Prepcort

Prestwick0_000447

Prestwick1_000447

Prestwick2_000447

Prestwick3_000447

Prestwick_265

Prevex HC

Proctocort

Proctofoam

Proctozone HC

Protocort

Racet

Rectasol-HC

Rectoid

Reichstein'S substance M

Reichstein's substance M

Remederm HC

S1696_Selleck

SAM002264617

SMP1_000156

SMR000059022

SMR000653523

SPBio_002433

Sanatison

Scalp-Cort

Scalpicin Capilar

Schericur

Scheroson F

Sigmacort

Signef

Stie-cort

Stiefcorcil

Synacort

Systral Hydrocort

Tarcortin

Texacort

Texacort lotion 25

Timocort

Topicort

Transderma H

Traumaide

UNII-WI4X0X7BPJ

UPCMLD-DP133

UPCMLD-DP133:001

Uniderm

Vioform-Hydrocortisone

VoSol HC

Vytone

Zenoxone

[3H]cortisol

component of Lubricort

component of Neo-Cort-Dome

component of Otalgine

hydrocortisone

5

Butyric Acid

experimental

Phase 2

380

107-92-6

264

Synonyms:

1-Butanoate

1-Butanoic acid

1-Butyrate

1-Butyric acid

1-Propanecarboxylate

1-Propanecarboxylic acid

1-propanecarboxylic acid

Butanate

Butanic acid

Butanoate

Butanoic acid

Buttersaeure

Butyrate

Butyric acid

Butyricum acidum

Ethylacetate

Ethylacetic acid

Honey robber

Kyselina maselna

N-Butanoate

N-Butanoic acid

N-Butyrate

N-Butyric acid

N-butanoic acid

N-butyric acid

Propanecarboxylate

Propanecarboxylic acid

Propylformate

Propylformic acid

6

Hydrocortisone-17-butyrate

Phase 2

332

7

Hydrocortisone acetate

Phase 2

667

8

Hydrocortisone 17-butyrate 21-propionate

Phase 2

667

9

Anti-Inflammatory Agents

Phase 2

10729

10

Cortisol succinate

Phase 2

667

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency	Completed	NCT00157118	Phase 2, Phase 3
2	Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study	Completed	NCT00732277	Phase 2
3	Sepsis-Associated Purpura Fulminans International Registry - Europe	Recruiting	NCT02238795

Search NIH Clinical Center for Purpura Fulminans

Cochrane evidence based reviews: purpura fulminans

Genetic Tests for Purpura Fulminans

Anatomical Context for Purpura Fulminans

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Purpura Fulminans:

³⁶

Skin, T cells, Breast, Liver, Brain, Bone

Publications for Purpura Fulminans

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Purpura Fulminans:

(show top 50) (show all 416)

id	Title	Authors	Year
1	Purpura Fulminans Associated with Overwhelming Postsplenectomy Infection. (28090064)	Sakai K.... Kuriyama A.	2017
2	Purpura fulminans secondary to rickettsial infections: A case series. (26955583)	Katoch S.... Gandhi S.	2016
3	Acute infectious purpura fulminans caused by group A I^-hemolytic Streptococcus: An uncommon organism. (27057503)	Gupta D.... Thappa D.M.	2016
4	Purpura fulminans associated with acute West Nile virus encephalitis. (26686320)	Shah S.... Parekh P.	2016
5	Purpura fulminans related to paroxysmal nocturnal haemoglobinuria. (27046923)	Rompoti N.... Dissemond J.	2016
6	Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult. (27583208)	Hale A.J.... Baden R.	2016
7	A Novel Protein C Mutation Causing Neonatal Purpura Fulminans. (27889735)	Devi R U.... Kawankar N.	2016
8	Strongyloides stercoralis hyperinfection in patient with autoimmune hepatitis and purpura fulminans. (26955218)	Rathor N.... Sarin S.K.	2016
9	Successful Corticosteroid Treatment for Purpura Fulminans Associated with Quinolone. (27746448)	Okamura I.... Kimura F.	2016
10	Streptococcus pneumoniae-induced purpura fulminans. (27083982)	Asakura T.... Mori N.	2016
11	Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. (27052576)	Manco-Johnson M.J.... Gelmont D.	2016
12	Lifetime cost of meningococcal disease in France: Scenarios of severe meningitis and septicemia with purpura fulminans. (26688376)	BAcnard S.... Gaudelus J.	2016
13	Purpura fulminans and severe sepsis due to Pasteurella multocida infection in an immunocompetent patient. (27298290)	Konda M.K.... Zaccheo M.	2016
14	Pneumococcal Sepsis Complicated by Splenic Abscesses and Purpura Fulminans in a 15-Month-Old Child: Case Report and Review of the Literature. (27006958)	Pangonis S.... Fitzpatrick E.	2016
15	Challenging Airway Secondary to Purpura Fulminans With Face and Neck Bullae in a Premature Infant. (27941484)	Ekeoduru R.A.... Nesrsta E.A.	2016
16	Severe Neonatal Purpura Fulminans Caused by Staphylococcus aureus. (27449990)	Nicolas L.... Samraj R.S.	2016
17	Purpura fulminans in the setting of Escherichia coli septicemia. (26761941)	Adotama P.... Dominguez A.R.	2015
18	Pravastatin-induced rhabdomyolysis and purpura fulminans in a patient with chronic renal failure. (25644555)	Kato K.... Furukawa H.	2015
19	Purpura fulminans 10 years after contaminated cocaine use. (26028121)	Martinez-Cabriales S.... Ocampo-Candiani J.	2015
20	Angioimmunoblastic t-cell lymphoma presenting as purpura fulminans. (25750965)	Miladi A.... Meyerle J.	2015
21	Infectious purpura fulminans. (25857509)	Harikrishna J.... Mohan A.	2015
22	Neonatal purpura fulminans due to protein C deficiency. (25783192)	Sharma S.... Plakkal N.	2015
23	Purpura Fulminans due to Enterobacter cloacae. (26370876)	Taniyama D.... Miyamoto K.	2015
24	Bilateral symmetrical digital gangrene of upper and lower limbs due to purpura fulminans caused by Streptococcus pyogenes: A rare entity. (25983440)	Ashokkumar G.K.... Singh B.R.	2015
25	1102: PROTEIN C FOR TREATMENT OF SEPSIS ASSOCIATED PURPURA FULMINANS. (26570763)	Meyer B.... Knoebl P.	2015
26	Purpura Fulminans Due to Acquired Protein C Deficiency. (26677306)	Mukherjee D.... Kundu R.	2015
27	Skin Necrosis and Purpura Fulminans in Children With and Without Thrombophilia-A Tertiary Center's Experience. (26436558)	Fruchtman Y.... Kenet G.	2015
28	Purpura Fulminans Secondary to Rickettsial Infection: A Case Report. (26673422)	Biradar S.... Kadeli D.K.	2015
29	From the toe to the head: metastatic endophalmitis following staphylococcal purpura fulminans. (24231686)	Sharma A.... Sharma V.	2014
30	Identification of differentially expressed serum proteins in infectious purpura fulminans. (24659849)	He T.... Huang Y.S.	2014
31	Indian tick typhus presenting as Purpura fulminans. (25097365)	Tirumala S.... Nimmala P.	2014
32	Fatal purpura fulminans and septic shock in asplenic patient with Streptococcus pneumoniae bacteremia. (24407746)	White C.... Draper H.M.	2014
33	Antiphospholipid antibody syndrome presenting with purpura fulminans. (23869929)	Choudhary S.... Kerdel F.	2013
34	Pneumococcal sepsis-induced purpura fulminans in an asplenic adult patient without disseminated intravascular coagulation. (24185261)	Saraceni C.... Schwed-Lustgarten D.	2013
35	Purpura fulminans: an unusual complication of malaria. (24076110)	Sharma A.... Sharma V.	2013
36	Purpura Fulminans following Thermal Injury. (23762660)	Hu J.... Luo Q.	2013
37	Primary meningococcal arthritis leading to Neisseria meningitidies purpura fulminans. (23599862)	Michel M.D.... Sloan B.K.	2013
38	A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans. (24158118)	Jain R.... Moses P.D.	2013
39	Purpura fulminans in a patient with paroxysmal nocturnal haemoglobinuria. (23324094)	May C.... Kennedy G.A.	2013
40	Plastic surgical treatment of purpura fulminans: Long-term follow-up of two patients. (23210495)	Hansson E.... Becker M.	2013
41	Purpura fulminans in an acute preterm neonate. (23250966)	Church J.... Hartnoll G.	2013
42	Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. (23840047)	Join-Lambert O.... Nassif X.	2013
43	Purpura fulminans caused by meningococcemia in an infant. (23921694)	Abbas A.... Mujeeb A.A.	2013
44	Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans. (23924269)	Lerolle N.... Borgel D.	2013
45	Limb fitting for quadruple amputees: report of two cases of symmetrical peripheral gangrene caused by pneumococcal purpura fulminans. (23558402)	Yoshimoto K.... Akai M.	2013
46	Purpura Fulminans after Therapeutic Hypothermia in an Asphyxiated Neonate with Streptococcemia. (23839905)	Fischer D.... Schloesser R.L.	2013
47	Purpura fulminans associated with Streptococcus pneumoniae septicemia in an asplenic pediatric patient. (23985086)	Konda S.... Alonso-Llamazares J.	2013
48	Streptococcus pneumoniae-induced purpura fulminans in a woman with functional asplenia. (23870635)	Wojtowicz J.M.... Longden Jones G.	2013
49	Purpura fulminans in a patient with mixed connective tissue disease. (23370948)	Murad A.A.... Connolly M.	2013
50	Neonatal purpura fulminans manifestation in early-onset group B Streptococcal infection. (23970945)	Albarrak M.... Al-Matary A.	2013

Genes related to Purpura Fulminans

Sources:
¹³DISEASES, ²¹GeneCards, ⁵⁰Novoseek
See all MalaCards sources

Genes related to Purpura Fulminans:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	56.14	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications, Summaries (show sections)	7841323, 9577159, 15748260 more 15186640
2	SERPINC1	Serpin Family C Member 1	44.24	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	9577159, 12761614, 11090052 more 2139671, 15186640, 18652566, 7848164, 12504371
3	F2	Coagulation Factor II, Thrombin	34.38	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
4	PROCR	Protein C Receptor	34.26	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	20077621
5	F3	Coagulation Factor III, Tissue Factor	33.46	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
6	SERPINF2	Serpin Family F Member 2	31.90	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)

Variations for Purpura Fulminans

Expression for genes affiliated with Purpura Fulminans

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

Sources:
³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁶PharmGKB, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome
See all MalaCards sources

Pathways related to Purpura Fulminans according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Warfarin Pathway, Pharmacodynamics⁵⁶	9.5	F2, PROC
2	Cell surface interactions at the vascular wall⁶⁰ Show member pathways Tie2 Signaling⁶⁰ PECAM1 interactions⁶⁰ Fibronectin matrix formation⁶⁰	8.9	F2, PROC, PROCR
3	Collagen chain trimerization⁶⁰ Show member pathways Assembly of collagen fibrils and other multimeric structures⁶⁰ Collagen formation⁶⁰ Protein digestion and absorption³⁴ Collagen biosynthesis and modifying enzymes⁶⁰ Crosslinking of collagen fibrils⁶⁰ Blood Coagulation Cascade⁵⁸ Intrinsic Prothrombin Activation Pathway⁵⁸ Anchoring fibril formation⁶⁰	8.3	F2, F3, PROC, SERPINC1
4	Response to elevated platelet cytosolic Ca2+⁶⁰ Show member pathways Hemostasis⁶⁰ Platelet activation, signaling and aggregation⁶⁰ Platelet degranulation⁶⁰ Disinhibition of SNARE formation⁶⁰	7.1	F2, F3, PROC, PROCR, SERPINC1, SERPINF2
5	Formation of Fibrin Clot (Clotting Cascade)⁶⁰ Show member pathways Blood Coagulation Signaling Pathways⁵⁹ Intrinsic Pathway of Fibrin Clot Formation⁶⁰ Blood Clotting Cascade⁴² Common Pathway of Fibrin Clot Formation⁶⁰ Extrinsic Prothrombin Activation Pathway⁵⁸ Extrinsic Pathway of Fibrin Clot Formation⁶⁰	7.1	F2, F3, PROC, PROCR, SERPINC1, SERPINF2
6	Complement and coagulation cascades³⁴ ⁴² Show member pathways Complement and Coagulation Cascades⁴²	7.1	F2, F3, PROC, PROCR, SERPINC1, SERPINF2

GO Terms for genes affiliated with Purpura Fulminans

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Purpura Fulminans according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.9	F2, PROC, SERPINC1
2	blood microparticle	GO:0072562	9.8	F2, SERPINC1, SERPINF2
3	cell surface	GO:0009986	9.3	F3, PROCR, SERPINF2
4	extracellular exosome	GO:0070062	8.3	F2, F3, PROCR, SERPINC1, SERPINF2
5	extracellular region	GO:0005576	7.8	F2, F3, PROC, PROCR, SERPINC1, SERPINF2
6	extracellular space	GO:0005615	7.7	F2, F3, PROC, SERPINC1, SERPINF2

Biological processes related to Purpura Fulminans according to GeneCards Suite gene sharing:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	10.1	F2, SERPINF2
2	fibrinolysis	GO:0042730	10.1	F2, SERPINF2
3	peptidyl-glutamic acid carboxylation	GO:0017187	10.0	F2, PROC
4	negative regulation of coagulation	GO:0050819	10.0	PROC, PROCR
5	negative regulation of fibrinolysis	GO:0051918	9.9	F2, SERPINF2
6	positive regulation of collagen biosynthetic process	GO:0032967	9.9	F2, SERPINF2
7	regulation of blood coagulation	GO:0030193	9.8	F2, SERPINC1
8	cellular protein metabolic process	GO:0044267	9.7	F2, PROC, SERPINC1
9	signal peptide processing	GO:0006465	9.5	F2, PROC
10	leukocyte migration	GO:0050900	9.4	F2, PROC, PROCR
11	blood coagulation	GO:0007596	8.3	F2, F3, PROC, PROCR, SERPINC1
12	hemostasis	GO:0007599	8.3	F2, F3, PROC, PROCR, SERPINC1

Molecular functions related to Purpura Fulminans according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase inhibitor activity	GO:0004867	9.5	SERPINC1, SERPINF2
2	protease binding	GO:0002020	9.3	F3, SERPINC1, SERPINF2
3	serine-type endopeptidase activity	GO:0004252	9.2	F2, F3, PROC