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MCID: PRP034
MIFTS: 46

Purpura Fulminans malady

Blood category
12 genes, 6 tissues, 168 related diseases, clinical trials.

Summaries for Purpura Fulminans

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64Wikipedia, 33MalaCards
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Wikipedia:64 Purpura fulminans (also known as \"Purpura gangrenosa\") is a haemorrhagic condition usually associated... more...

MalaCards: Purpura Fulminans is related to sepsis and protein c deficiency. An important gene associated with Purpura Fulminans is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are PTM: gamma carboxylation, hypusine formation and arylsulfatase activation and Platelet activation, signaling and aggregation. The compounds serine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are nervous system and hematopoietic system.

Aliases & Classifications for Purpura Fulminans

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Sources:
49Orphanet, 61UMLS, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood
ICD10: 26


Aliases & Descriptions:

purpura fulminans 49 61


External Ids:

SNOMED-CT via Orphanet58 13507004
UMLS via Orphanet62 C0043068, C0085650
MESH via Orphanet36 D014884, D055665
ICD10 via Orphanet26 D65

Related Diseases for Purpura Fulminans

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17GeneCards, 18GeneDecks
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Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.3LACTB, F2, F3, PROC, PROCR, F5
2protein c deficiency31.1SERPINC1, F2, PROC, PROCR, MTHFR, F5
3protein s deficiency31.1APOH, F5, MTHFR, F3, F2, SERPINC1
4meningococcemia31.0PROCR, SERPINC1, F5
5septic shock30.5C1S, CSF3, F5, F3, LACTB, SERPINC1
6arthritis30.4LACTB
7systemic lupus erythematosus30.4C1S, APOH, PROCR, F3, F2
8antiphospholipid syndrome30.3SERPINC1, PLAT, F2, F3, PROCR, MTHFR
9hepatitis c30.2F2
10toxic shock syndrome30.1LACTB
11angioedema30.1C1S, PLAT
12vasculitis30.1C1S, APOH, F2
13factor v deficiency30.1F5, F3, F2
14chickenpox10.5
15protein r deficiency10.5
16necrotizing fasciitis10.4
17scarlet fever10.4
18burns10.1
19osteonecrosis10.1
20hereditary angioedema10.1
21subdural empyema10.1
22mixed connective tissue disease10.1
23stevens-johnson syndrome10.1
24dengue hemorrhagic fever10.1
25polyarteritis nodosa10.1
26thrombotic thrombocytopenic purpura10.1
27ulcerative colitis10.1
28measles10.1
29streptococcal meningitis10.1
30churg-strauss syndrome10.1
31adult syndrome10.1
32cryptococcosis10.1
33aplastic anemia10.1
34micro syndrome10.1
35catastrophic antiphospholipid syndrome10.1
36hemorrhagic fever10.1
37klebsiella10.1
38neonatal meningitis10.1
39stenotrophomonas maltophilia10.1
40hemoglobin so10.1
41malaria, severe10.1
42bacteremia10.1
43thrombophilia due to protein s deficiency, autosomal recessive10.1
44c4b deficiency10.1
45meningococcal meningitis10.1
46patent foramen ovale10.0F5
47ovarian hyperstimulation syndrome10.0F5
48purpura10.0SERPINC1
49branch retinal artery occlusion10.0F5
50thrombophlebitis10.0APOH

Graphical network of the top 20 diseases related to Purpura Fulminans:



Diseases related to purpura fulminans

Clinical Features for Purpura Fulminans

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Drugs & Therapeutics for Purpura Fulminans

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Purpura Fulminans

Drug clinical trials:

Search ClinicalTrials for Purpura Fulminans

Search NIH Clinical Center for Purpura Fulminans

Search CenterWatch for Purpura Fulminans

Genetic Tests for Purpura Fulminans

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Anatomical Context for Purpura Fulminans

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33MalaCards
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MalaCards organs/tissues related to Purpura Fulminans:

33
Skin, Liver, Brain, Breast, T cells, B cells

Animal Models for Purpura Fulminans or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Purpura Fulminans:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
nervous system phenotype
MP:00036317.6MTHFR, PROC, F3, F2, PLAT, SERPINC1
2
hematopoietic system phenotype
MP:00053977.3CSF3, PROCR, PROC, F3, F2, PLAT
3
immune system phenotype
MP:00053877.1CSF3, PROCR, PROC, F3, F2, PLAT
4
homeostasis/metabolism phenotype
MP:00053767.0SERPINC1, APOH, F5, MTHFR, PROCR, PROC
5
mortality/aging
MP:00107686.9APOH, F5, MTHFR, PROCR, PROC, F3

Publications for Purpura Fulminans

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Sources:
51PubMed
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Articles related to Purpura Fulminans:

(show top 50)    (show all 387)
idTitleAuthorsYear
1
From the toe to the head: metastatic endophalmitis following staphylococcal purpura fulminans. (24231686)
2014
2
Nose and upper lip reconstruction for purpura fulminans. (21795130)
2012
3
Purpura fulminans in Neisseria meningitidis B as presenting feature of multiple myeloma. (22897973)
2012
4
Purpura fulminans in a child: a case report. (23373061)
2012
5
Diagnosis and management of neonatal purpura fulminans. (21839696)
2011
6
Purpura fulminans: recognition, diagnosis and management. (21233082)
2011
7
Varicella-associated purpura fulminans and multiple deep vein thromboses: a case report. (19602824)
2009
8
Inpatient rehabilitation of survivors of purpura fulminans with multiple limb amputations: a case series. (19345788)
2009
9
Hypothesis: is the skin and tissue loss associated with septic purpura fulminans temperature related? Parallels with the anatomical distribution of frostbite. (18221840)
2008
10
Purpura fulminans skin loss: surgical management protocols at a regional burns centre. (17825634)
2008
11
Purpura fulminans: an unusual manifestation of severe falciparum malaria. (17588627)
2007
12
Detection of Neisseria meningitidis DNA from skin lesion biopsy using real-time PCR: usefulness in the aetiological diagnosis of purpura fulminans. (17503017)
2007
13
Purpura fulminans associated with Lactobacillus paracasei liver abscess. (17323680)
2007
14
Purpura fulminans in an asplenic patient. (17897291)
2007
15
Purpura fulminans in a child secondary to Panton-Valentine leukocidin-producing Staphylococcus aureus. (17893182)
2007
16
Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies. (16137345)
2005
17
Plastic surgery management in pediatric meningococcal-induced purpura fulminans. (15636769)
2005
18
Homozygous type I Protein C deficiency in neonatal purpura fulminans with a novel frame-shift deletion of 10 base pairs in exon 8 of PROC gene. (15748260)
2005
19
Capnocytophaga canimorsus sepsis with purpura fulminans and symmetrical gangrene following a dog bite in a shelter employee. (15201655)
2004
20
Current management of purpura fulminans: a multicenter study. (12792230)
2003
21
An unusual varicella zoster infection complicated by purpura fulminans and multiorgan failure in a healthy infant. (12685891)
2003
22
Purpura fulminans and anticardiolipin antibodies in a patient with Grave's disease. (12492254)
2002
23
Protein C substitution in sepsis-associated purpura fulminans. (10921567)
2000
24
Purpura fulminans caused by group A beta-hemolytic Streptococcus sepsis. (11035839)
2000
25
Purpura fulminans complicating pneumococcal sepsis. (10048620)
1999
26
Infectious purpura fulminans: caution needed in the use of protein C. (10444197)
1999
27
Neurovascularized saphenous island flap in a patient with meningococcal sepsis and purpura fulminans. (9678482)
1998
28
Integra Artificial Skin as a useful adjunct in the treatment of purpura fulminans. (9710731)
1998
29
Surgical treatment of extensive skin necrosis secondary to purpura fulminans in a patient with meningococcal sepsis. (9677033)
1998
30
Purpura fulminans: a disease best managed in a burn center. (9556312)
1998
31
Management strategy in purpura fulminans with multiple organ failure in children. (8719318)
1996
32
A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy. (7841323)
1994
33
Epidural sympathetic blockade to relieve vascular insufficiency in an infant with purpura fulminans. (8375170)
1993
34
Extremity amputations in meningococcemia-induced purpura fulminans. (1561259)
1992
35
Purpura fulminans secondary to Xanthomonas maltophilia sepsis in an adult with aplastic anemia. (1918597)
1991
36
Use of topically applied nitroglycerin in the treatment of purpura fulminans. (2123242)
1990
37
Brazilian purpuric fever: epidemic purpura fulminans associated with antecedent purulent conjunctivitis. Brazilian Purpuric Fever Study Group. (2888985)
1987
38
Purpura fulminans in an adult. (3793438)
1986
39
Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. (3838081)
1985
40
Purpura fulminans produced by Aeromonas hydrophila: a case report. (3835694)
1985
41
Purpura fulminans. (7112693)
1982
42
Purpura fulminans. (788514)
1976
43
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. (1147459)
1975
44
Intrauterine purpura fulminans. (1236133)
1975
45
Purpura fulminans with haemolytic anaemia. (4469044)
1974
46
Purpura fulminans (a case report). (4792711)
1973
47
Purpura fulminans in a child with pneumococcal septicemia two years after splenectomy. (5468716)
1970
48
Purpura fulminans in a newborn baby. (13924541)
1962
49
A case of purpura fulminans with fibrinogenopenia in association with scarlatina. (20247947)
1947
50
Purpura Fulminans. (19974790)
1910

Genetic Variations for Purpura Fulminans

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Expression for genes affiliated with Purpura Fulminans

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura Fulminans

Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

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54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 30KEGG
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Pathways related to Purpura Fulminans according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation54
9.8F2, PROC
2
Platelet activation, signaling and aggregation54
Hide members
9.6F2, F3
3
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins54
Hide members
9.3PROC, F3, F2
4
Selenium Pathway38
8.9PLAT, F2, MTHFR
5
Collagen biosynthesis and modifying enzymes54
Hide members
8.7SERPINC1, F2, F3, PROC, F5
6
Common Pathway54
Hide members
8.7F5, PROC, F3, F2, SERPINC1
7
Formation of Fibrin Clot (Clotting Cascade)54
Hide members
8.2F5, PROC, F3, F2, PLAT, SERPINC1
8
Complement and coagulation cascades30
Hide members
7.9SERPINC1, C1S, F5, PROC, F3, F2

Compounds for genes affiliated with Purpura Fulminans

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Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Purpura Fulminans according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1serine4510.0LACTB, PROCR
2coumarins4510.0F3, APOH
3warfarin45 50 11 2413.0APOH, PROC, SERPINC1
4hirugen459.6SERPINC1, F2, F5
5certoparin459.6F3, SERPINC1, F2
6heparin45 29 11 2412.6MTHFR, C1S, APOH
7reviparin459.4PLAT, F3, SERPINC1
8inogatran459.4F5, F3, SERPINC1, F2
9ecarin459.4SERPINC1, F5, F2, F3
10efegatran459.4SERPINC1, PLAT, F3
11danaparoid459.4F5, F3, F2, SERPINC1
12ximelagatran45 1110.4F5, F3, F2, SERPINC1
13heparinoids459.4SERPINC1, F5, F3, F2
14kaolin459.3F2, APOH, F5, F3
15heparin sodium459.3F3, PLAT, F2
16ancrod459.3PLAT, F5, F2, SERPINC1
17polybrene459.3SERPINC1, F3, F2
18hepaplastin459.3F3, SERPINC1, F2
19dextran 70459.3F3, F2, PLAT
20gamma-carboxyglutamic acid459.2F5, F3, PROCR, F2, PROC
21coumarin45 2 50 2412.1F5, F2, F3, SERPINC1
22ppack459.1F3, F2, SERPINC1, PLAT
23tirofiban45 1110.1F2, SERPINC1, PLAT, F3
24epsilon aminocaproic acid459.1SERPINC1, PLAT, F2, F3
25ticlopidine45 1110.1APOH, SERPINC1, F3, PLAT
26aprotinin45 1110.0C1S, F3, F5, PLAT, SERPINC1
27spectrozyme458.9SERPINC1, F3, F5, PLAT, F2
28fondaparinux458.9SERPINC1, F5, F3, F2, PLAT
29bivalirudin45 119.9F5, PLAT, F2, SERPINC1, F3
30argatroban45 119.9F5, F3, F2, PLAT, SERPINC1
31protamine sulfate458.9F3, F5, SERPINC1, PLAT, F2
32ristocetin458.9SERPINC1, F2, F3, F5, PLAT
33levonorgestrel45 60 29 1111.9PLAT, F2, F3, F5, SERPINC1
34desmopressin45 60 29 1111.9F3, F2, SERPINC1, F5, PLAT
35protamine458.8SERPINC1, PLAT, F2, F3, F5
36tranexamic acid45 119.8C1S, F3, PLAT, SERPINC1, F2
37dermatan sulfate458.8F2, F5, F3, PLAT, SERPINC1
38clopidogrel50 45 11 2411.8PLAT, F3, F2, SERPINC1
39abciximab45 119.8PLAT, SERPINC1, F3, F2, C1S
40phosphatidylethanolamine45 119.8PROCR, F2, APOH, F5
41hydroxyethyl starch458.8CSF3, SERPINC1, F3, F2
42hirudin458.6F5, F3, F2, PLAT, SERPINC1, PROCR
43phospholipid458.6F3, PROC, PROCR, F5, F2, APOH
44prostacyclin458.5SERPINC1, F3, F5, APOH, C1S, PLAT
45kininogen458.2C1S, APOH, F5, F3, PLAT, SERPINC1
46homocysteine45 248.9SERPINC1, APOH, PLAT, F2, MTHFR, F5
47cyclophosphamide45 50 119.8APOH, F5, F3, MTHFR, CSF3
48creatinine457.8F3, SERPINC1, PLAT, F2, F5, APOH
49aspirin45 50 29 2410.6F2, C1S, SERPINC1, PLAT, F3, APOH
50fibrinogen457.0APOH, C1S, F5, MTHFR, SERPINC1, PLAT

GO Terms for genes affiliated with Purpura Fulminans

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16Gene Ontology
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Cellular components related to Purpura Fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PLAT, F3, APOH
2extracellular regionGO:0055768.0C1S, F5, PROC, F2, PLAT, SERPINC1
3extracellular spaceGO:0056157.2SERPINC1, CSF3, APOH, F5, F3, F2

Biological processes related to Purpura Fulminans according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.9PROC, F2
2negative regulation of blood coagulationGO:0301959.9PROC, APOH
3negative regulation of fibrinolysisGO:0519189.9F2, APOH
4positive regulation of blood coagulationGO:0301949.8APOH, F2
5plasminogen activationGO:0316399.8PLAT, APOH
6negative regulation of proteolysisGO:0458619.5F2, PLAT
7fibrinolysisGO:0427309.4F2, PLAT
8blood coagulation, intrinsic pathwayGO:0075979.4APOH, F2
9proteolysisGO:0065088.9PLAT, F2, PROC, C1S
10blood coagulationGO:0075968.1SERPINC1, F5, PROCR, PROC, F3, F2

Molecular functions related to Purpura Fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.6PLAT, F2, PROC, C1S
2protein bindingGO:0055157.2APOH, F5, PROCR, PROC, F3, F2

Products for genes affiliated with Purpura Fulminans

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  • Antibodies
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Sources for Purpura Fulminans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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