MCID: PRP034
MIFTS: 38

Purpura Fulminans malady

Blood diseases category

Summaries for Purpura Fulminans

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63Wikipedia, 32MalaCards
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Wikipedia:63 Purpura fulminans (also known as \"Purpura gangrenosa\") is an acute, often fatal, thrombotic disorder... more...

MalaCards: Purpura Fulminans is related to purpura and protein c deficiency. An important gene associated with Purpura Fulminans is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are PTM: gamma carboxylation, hypusine formation and arylsulfatase activation and Platelet activation, signaling and aggregation. The compounds serine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are nervous system and hematopoietic system.

Aliases & Classifications for Purpura Fulminans

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

purpura fulminans 48 60


External Ids:

SNOMED-CT via Orphanet57 13507004
UMLS via Orphanet61 C0043068, C0085650
MESH via Orphanet35 D014884, D055665
ICD10 via Orphanet26 D65

Related Diseases for Purpura Fulminans

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17GeneCards, 18GeneDecks
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Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1purpura32.1SERPINC1
2protein c deficiency31.2SERPINC1, F2, PROC, PROCR, MTHFR, F5
3protein s deficiency31.0APOH, F5, MTHFR, F3, F2, SERPINC1
4disseminated intravascular coagulation30.9F5, PROC, F3, F2, PLAT, SERPINC1
5pneumonia30.8LACTB, CSF3
6meningitis30.7LACTB
7influenza30.5LACTB
8factor v deficiency30.5F5, F3, F2
9lupus erythematosus30.4C1S, APOH, F5, PROCR, F3, F2
10arthritis30.3LACTB
11systemic lupus erythematosus30.3C1S, APOH, PROCR, F3, F2
12leukemia30.3LACTB, MTHFR, CSF3
13antiphospholipid syndrome30.3SERPINC1, PLAT, F2, F3, PROCR, MTHFR
14hepatitis a30.1F2
15hepatitis30.1F2
16endocarditis30.1LACTB
17toxic shock syndrome30.1LACTB
18ischemia30.1C1S, PLAT
19multiple myeloma30.1CSF3
20myeloma30.1CSF3
21angioedema30.1C1S, PLAT
22peritonitis30.1LACTB, F2
23endophthalmitis30.1LACTB, PLAT
24vasculitis30.1C1S, APOH, F2
25galactosemia30.1F3, F2, SERPINC1
26rheumatoid arthritis30.1C1S, APOH, MTHFR
27hemolytic anemia30.1APOH, F3, LACTB
28factor vii deficiency30.1F5, F3, F2, SERPINC1
29connective tissue disease30.1C1S, APOH, F3, F2
30antithrombin iii deficiency30.1SERPINC1, F2, MTHFR, F5, APOH
31chickenpox10.5
32burns10.4
33malaria10.4
34necrotizing fasciitis10.3
35scarlet fever10.3
36fasciitis10.3
37osteonecrosis10.1
38hereditary angioedema10.1
39subdural empyema10.1
40mixed connective tissue disease10.1
41stevens-johnson syndrome10.1
42dengue hemorrhagic fever10.1
43polyarteritis nodosa10.1
44thrombotic thrombocytopenic purpura10.1
45ulcerative colitis10.1
46measles10.1
47streptococcal meningitis10.1
48churg-strauss syndrome10.1
49adult syndrome10.1
50cryptococcosis10.1

Graphical network of the top 20 diseases related to Purpura Fulminans:



Diseases related to purpura fulminans

Clinical Features for Purpura Fulminans

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Drugs & Therapeutics for Purpura Fulminans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Purpura Fulminans

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Anatomical Context for Purpura Fulminans

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32MalaCards
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MalaCards organs/tissues related to Purpura Fulminans:

32
Skin

Animal Models for Purpura Fulminans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Purpura Fulminans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6F2, SERPINC1, F5, MTHFR, PROC, F3
2MP:00053977.3CSF3, PROCR, PROC, F2, PLAT, SERPINC1
3MP:00053877.1SERPINC1, F2, F3, PROC, PROCR, PLAT
4MP:00053767.0APOH, SERPINC1, PLAT, F2, F3, PROC
5MP:00107686.9SERPINC1, APOH, F5, PROCR, PROC, F3

Publications for Purpura Fulminans

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Genetic Variations for Purpura Fulminans

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Expression for genes affiliated with Purpura Fulminans

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Purpura Fulminans

Search GEO for disease gene expression data for Purpura Fulminans.

Pathways for genes affiliated with Purpura Fulminans

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Purpura Fulminans

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Purpura Fulminans according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1serine4410.0PROCR, LACTB
2coumarins4410.0APOH, F3
3warfarin44 49 11 2413.0APOH, PROC, SERPINC1
4hirugen449.6F5, F2, SERPINC1
5certoparin449.6F3, F2, SERPINC1
6heparin44 28 11 2412.6MTHFR, APOH, C1S
7reviparin449.4F3, PLAT, SERPINC1
8inogatran449.4F5, F3, F2, SERPINC1
9ecarin449.4F5, F3, F2, SERPINC1
10efegatran449.4F3, PLAT, SERPINC1
11danaparoid449.4SERPINC1, F2, F3, F5
12ximelagatran44 1110.4F5, F3, F2, SERPINC1
13heparinoids449.4F5, F3, F2, SERPINC1
14kaolin449.3F2, F3, F5, APOH
15heparin sodium449.3F3, F2, PLAT
16ancrod449.3F5, F2, PLAT, SERPINC1
17polybrene449.3F3, F2, SERPINC1
18hepaplastin449.3SERPINC1, F2, F3
19dextran 70449.2F3, F2, PLAT
20gamma-carboxyglutamic acid449.2F5, PROCR, PROC, F3, F2
21coumarin44 2 49 2412.1F5, F3, F2, SERPINC1
22ppack449.1F3, F2, PLAT, SERPINC1
23tirofiban44 1110.1SERPINC1, PLAT, F2, F3
24epsilon aminocaproic acid449.1F3, F2, PLAT, SERPINC1
25ticlopidine44 1110.1APOH, F3, PLAT, SERPINC1
26aprotinin44 1110.0SERPINC1, PLAT, F3, F5, C1S
27spectrozyme448.9SERPINC1, PLAT, F2, F3, F5
28fondaparinux448.9F5, F3, F2, PLAT, SERPINC1
29bivalirudin44 119.9F5, F3, F2, PLAT, SERPINC1
30argatroban44 119.9F5, F3, F2, PLAT, SERPINC1
31protamine sulfate448.9F5, F3, F2, PLAT, SERPINC1
32ristocetin448.9SERPINC1, PLAT, F2, F3, F5
33levonorgestrel44 59 28 1111.9F5, F3, F2, PLAT, SERPINC1
34desmopressin44 59 28 1111.9F5, F3, F2, PLAT, SERPINC1
35protamine448.8SERPINC1, PLAT, F2, F3, F5
36tranexamic acid44 119.8PLAT, F2, F3, C1S, SERPINC1
37clopidogrel49 44 11 2411.8F3, F2, PLAT, SERPINC1
38dermatan sulfate448.8F5, F3, F2, PLAT, SERPINC1
39abciximab44 119.8C1S, F3, F2, PLAT, SERPINC1
40hydroxyethyl starch448.8CSF3, F3, F2, SERPINC1
41phosphatidylethanolamine44 119.8APOH, F5, PROCR, F2
42hirudin448.6F5, PROCR, F3, F2, PLAT, SERPINC1
43phospholipid448.6APOH, F5, PROCR, PROC, F3, F2
44prostacyclin448.5C1S, APOH, F5, F3, PLAT, SERPINC1
45kininogen448.2C1S, APOH, SERPINC1, PLAT, F2, F3
46homocysteine44 248.9APOH, F5, MTHFR, F3, F2, PLAT
47cyclophosphamide44 49 119.8F3, MTHFR, F5, APOH, CSF3
48creatinine447.8APOH, F5, MTHFR, F3, F2, PLAT
49aspirin44 49 28 2410.6C1S, APOH, F5, MTHFR, F3, F2
50fibrinogen447.0SERPINC1, C1S, APOH, F5, MTHFR, PROCR

GO Terms for genes affiliated with Purpura Fulminans

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16Gene Ontology
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Cellular components related to Purpura Fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PLAT, F3, APOH
2extracellular regionGO:0055768.0C1S, F5, PROC, F2, PLAT, SERPINC1
3extracellular spaceGO:0056157.2SERPINC1, CSF3, APOH, F5, F3, F2

Biological processes related to Purpura Fulminans according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.9PROC, F2
2negative regulation of blood coagulationGO:0301959.9PROC, APOH
3negative regulation of fibrinolysisGO:0519189.9APOH, F2
4positive regulation of blood coagulationGO:0301949.8APOH, F2
5plasminogen activationGO:0316399.8APOH, PLAT
6fibrinolysisGO:0427309.5F2, PLAT
7negative regulation of proteolysisGO:0458619.4F2, PLAT
8blood coagulation, intrinsic pathwayGO:0075979.4F2, APOH
9proteolysisGO:0065088.9F2, PROC, C1S, PLAT
10blood coagulationGO:0075968.1F3, F5, SERPINC1, PLAT, F2, PROCR

Molecular functions related to Purpura Fulminans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.6PLAT, F2, PROC, C1S
2protein bindingGO:0055157.2APOH, F5, PROCR, PROC, F3, F2

Products for genes affiliated with Purpura Fulminans

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  • Antibodies
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Sources for Purpura Fulminans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet