MCID: PST059
MIFTS: 36

Pustular Psoriasis

Categories: Rare diseases, Genetic diseases, Skin diseases, Bone diseases, Blood diseases

Aliases & Classifications for Pustular Psoriasis

MalaCards integrated aliases for Pustular Psoriasis:

Name: Pustular Psoriasis 50 52 69

Classifications:



Summaries for Pustular Psoriasis

NIH Rare Diseases : 50 pustular psoriasis is a rare form of psoriasis that is characterized by widespread pustules and reddish skin. this condition can occur alone or with plaque-type psoriasis. most cases of pustular psoriasis are thought to be "multifactorial" or associated with the effects of multiple genes in combination with lifestyle and environmental factors. there are several triggers for this conditions including withdrawal from corticosteroids, exposure to various medications and/or infections. some cases of the generalized form are caused by changes (mutations) in the il36rn gene and are inherited in an autosomal recessive pattern. in severe cases, hospitalization may be required. treatment aims to alleviate the associated symptoms and may include certain medications and/or phototherapy. last updated: 11/11/2015

MalaCards based summary : Pustular Psoriasis is related to psoriasis 14, pustular and bullous pemphigoid. An important gene associated with Pustular Psoriasis is AP1S3 (Adaptor Related Protein Complex 1 Sigma 3 Subunit), and among its related pathways/superpathways are Matrix Metalloproteinases and NF-kappa B signaling pathway. The drugs Antibodies and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and neutrophil.

Wikipedia : 72 The term pustular psoriasis is used for a heterogeneous group of diseases that share pustular skin... more...

Related Diseases for Pustular Psoriasis

Diseases in the Pustular Psoriasis family:

Psoriasis 14, Pustular Psoriasis 15, Pustular

Diseases related to Pustular Psoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 34.0 AP1S3 IL36RN
2 bullous pemphigoid 28.7 ELANE IL36RN PI3
3 pustulosis palmaris et plantaris 12.0
4 impetigo herpetiformis 11.7
5 psoriasis 15, pustular 11.6
6 psoriasis susceptibility 1 11.2
7 pustulosis of palm and sole 11.0
8 psoriasis 10.9
9 x-linked intellectual disability, cilliers type 10.4 AP1S3 IL36RN
10 dermatosis papulosa nigra 10.2 IL36RN TNF
11 ciliary dyskinesia, primary, 15 10.2 CARD14 IL36RN
12 anaerobic meningitis 10.2 IL36RN TNF
13 arthritis 10.2
14 acute generalized exanthematous pustulosis 10.2
15 psoriatic arthritis 10.1
16 acrodermatitis 10.1
17 lung sarcoma 10.1 PI3 TNF
18 impetigo 10.0
19 subcorneal pustular dermatosis 10.0
20 pemphigus 10.0
21 acute respiratory distress syndrome 10.0
22 hypoparathyroidism 9.9
23 capillary leak syndrome 9.9
24 turner syndrome 9.9
25 vasculitis 9.9
26 cholangitis 9.9
27 chromoblastomycosis 9.8 ELANE TNF
28 bardet-biedl syndrome 8 9.8 ELANE TNF
29 rheumatoid arthritis 9.8
30 netherton syndrome 9.8
31 crohn's disease 9.8
32 hepatitis 9.8
33 pemphigus foliaceus 9.8
34 pneumonia 9.8
35 thyroiditis 9.8
36 alcohol abuse 9.8 ELANE TNF
37 benign mammary dysplasia 9.8 ELANE TNF
38 neonatal period electroclinical syndrome 9.8 ELANE TNF
39 placenta praevia 9.8 ELANE PI3
40 germ cell and embryonal cancer 9.8 ELANE TNF
41 spontaneous ocular nystagmus 9.7 ELANE TNF
42 shigellosis 9.7 ELANE PI3
43 ragweed sensitivity 9.7 ELANE TNF
44 small non-cleaved cell lymphoma 9.7 CARD14 IL36RN TNF
45 diastrophic dysplasia 9.7 ELANE PI3
46 nasal cavity carcinoma in situ 9.7 ELANE TNF
47 acute chest syndrome 9.7 ELANE TNF
48 hepatitis c virus 9.7
49 bacteremia 9.7
50 alopecia universalis 9.7

Graphical network of the top 20 diseases related to Pustular Psoriasis:



Diseases related to Pustular Psoriasis

Symptoms & Phenotypes for Pustular Psoriasis

Drugs & Therapeutics for Pustular Psoriasis

Drugs for Pustular Psoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Phase 3
2 Antibodies, Monoclonal Phase 4,Phase 3
3 Immunoglobulins Phase 4,Phase 3
4
Acitretin Approved Phase 3 55079-83-9 6437841 5284513
5
Dimethyl fumarate Approved, Investigational Phase 3 624-49-7 5271565 637568
6
Methoxsalen Approved Phase 3 298-81-7 4114
7
Menthol Approved Phase 3 2216-51-5 16666
8
Adalimumab Approved Phase 3 331731-18-1 16219006
9
Infliximab Approved Phase 3 170277-31-3
10
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
11
Certolizumab pegol Approved Phase 2, Phase 3 428863-50-7
12
Ustekinumab Approved, Investigational Phase 3 815610-63-0
13 tannic acid Approved, Nutraceutical Phase 2, Phase 3
14 5-methoxypsoralen Phase 3
15 Dermatologic Agents Phase 3,Phase 2
16 Keratolytic Agents Phase 3,Phase 2
17 Photosensitizing Agents Phase 3
18 Anti-Inflammatory Agents Phase 3
19 Antirheumatic Agents Phase 3,Phase 2
20 Gastrointestinal Agents Phase 3
21 Immunosuppressive Agents Phase 2, Phase 3
22 Pharmaceutical Solutions Phase 2, Phase 3
23
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795
24
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538
25 Interleukin 1 Receptor Antagonist Protein Phase 2
26 tyrosine Nutraceutical

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
2 Fumaric Acid Ester-PUVA Therapy Versus Acitretin -PUVA Therapy in Pustular Palmoplantar Psoriasis Unknown status NCT00811005 Phase 3
3 Palmoplantar Pustular Psoriasis Efficacy and Safety wIth Secukinumab Completed NCT02008890 Phase 3 Placebo
4 Study to Assess the Efficacy, Safety and Tolerability of Secukinumab in Japanese Subjects With Generalized Pustular Psoriasis (GPP) Completed NCT01952015 Phase 3
5 Study to Investigate Efficacy and Safety of Adalimumab in Japanese Subjects With Generalized Pustular Psoriasis (GPP) Completed NCT02533375 Phase 3 Adalimumab
6 An Open-label, Non-controlled Study of KHK4827 in Subjects With Psoriasis Completed NCT01782937 Phase 3 KHK4827
7 A Phase 3 Clinical Study of KHK 4827 Completed NCT02052609 Phase 3 KHK4827 140mg SC;KHK4827 210mg SC
8 A Clinical Study of Increased Dose of TA-650 in Patients With Psoriasis Completed NCT01680159 Phase 3 TA-650
9 Study to Evaluate the Efficacy of Infliximab Induction Therapy for Patients With Palmoplantar Psoriasis (PPP)(Study P04555)(COMPLETED) Completed NCT00686686 Phase 3
10 A Study to Test the Efficacy and Safety of Certolizumab Pegol in Japanese Subjects With Moderate to Severe Chronic Psoriasis Recruiting NCT03051217 Phase 2, Phase 3 Certolizumab Pegol
11 An Efficacy and Safety Study of CNTO1959 (Guselkumab) in the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis Active, not recruiting NCT02343744 Phase 3 Guselkumab
12 A Study to Assess Efficacy and Safety of Two Different Dose Regimens of Risankizumab Administered Subcutaneously in Japanese Subjects With Generalized Pustular Psoriasis or Erythrodermic Psoriasis Active, not recruiting NCT03022045 Phase 3 risankizumab
13 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)
14 Determination of the Efficacy and Safety of Psirelax in the Relief of the Disease in Psoriasis Completed NCT01000714 Phase 2 Psirelax
15 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2 Alefacept
16 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2 alitretinoin;Placebo
17 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Recruiting NCT03135548 Phase 2 BI 655130 (low dose);Placebo;BI 655130 (high dose)
18 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
19 BI655130 Single Dose in Generalized Pustular Psoriasis Recruiting NCT02978690 Phase 1 BI655130
20 IL-17 Role in Variants of Psoriasis Completed NCT02078297
21 Role of Tyrosine Kinase Lyn and Cleaved Form by Caspases in Psoriasis Recruiting NCT01538342
22 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustular Psoriasis

Genetic Tests for Pustular Psoriasis

Anatomical Context for Pustular Psoriasis

MalaCards organs/tissues related to Pustular Psoriasis:

39
Skin, Monocytes, Neutrophil, Testes, Bone, Tongue, Thyroid

Publications for Pustular Psoriasis

Articles related to Pustular Psoriasis:

(show top 50) (show all 368)
id Title Authors Year
1
Generalized Pustular Psoriasis With IL-36 Receptor Antagonist Mutation Successfully Treated With Granulocyte and Monocyte Adsorption Apheresis Accompanied by Reduced Serum IL-6 Level. ( 28913961 )
2017
2
Recalcitrant infantile generalized pustular psoriasis successfully treated with acitretin and narrowband ultraviolet B. ( 28106270 )
2017
3
Autosomal dominant familial generalized pustular psoriasis caused by a CARD14 mutation. ( 28295164 )
2017
4
Granulocyte and monocyte apheresis can control juvenile generalised pustular psoriasis with mutation of the IL36RN gene. ( 28369922 )
2017
5
Generalized pustular psoriasis: A possible association with severe hypocalcaemia due to primary hypoparathyroidism. ( 28106254 )
2017
6
Acquired hemophilia A following generalized pustular psoriasis of pregnancy. ( 28771773 )
2017
7
Case of generalized pustular psoriasis presenting with both pleural effusion and pericardial effusion collection. ( 28636215 )
2017
8
Acute Generalized Erythrodermic Pustular Psoriasis Associated with Bupropion/Naltrexone (Contrave(Ar)). ( 28130024 )
2017
9
A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. ( 27802907 )
2017
10
European consensus statement on phenotypes of pustular psoriasis. ( 28585342 )
2017
11
Rare diseases and costly treatments: the role of IL-1I^ in pustular psoriasis. ( 28098365 )
2017
12
Short- and Long-Term Management of an Acute Pustular Psoriasis Flare: A Case Report. ( 28535721 )
2017
13
Generalised pustular psoriasis and neutrophilic cholangitis: An infrequently reported association with excellent response to tumour necrosis factor inhibitors. ( 28195322 )
2017
14
Juvenile generalized pustular psoriasis is a chronic recalcitrant disease: an analysis of 27 patients seen in a tertiary hospital in Johor, Malaysia. ( 28194751 )
2017
15
Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway. ( 27743912 )
2017
16
Generalized Pustular Psoriasis. ( 28629688 )
2017
17
Successful Secukinumab treatment of generalized pustular psoriasis and erythrodermic psoriasis. ( 28319281 )
2017
18
Interleukin-17 blockade in generalized pustular psoriasis - new hope for severely ill patients. ( 28300318 )
2017
19
A dramatic response to a single dose of infliximab in a patient with prolonged pustular psoriasis derived from inverse psoriasis. ( 28419647 )
2017
20
Annular pustular psoriasis in a 14-month-old girl: a therapeutic challenge. ( 27997815 )
2017
21
Clearance of annular pustular psoriasis with ustekinumab. ( 28202422 )
2017
22
Perianal streptococcal infection precipitating pustular psoriasis in an adult. ( 27504479 )
2016
23
Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner. ( 28057979 )
2016
24
Generalized pustular psoriasis associated with Turner syndrome and dilated cardiomyopathy. ( 26870904 )
2016
25
Generalized pustular psoriasis treated with ustekinumab. ( 27333948 )
2016
26
Rebound pustular psoriasis after brodalumab discontinuation. ( 27037661 )
2016
27
Successful use of secukinumab in pustular psoriasis. ( 27981221 )
2016
28
Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions. ( 27450766 )
2016
29
Ustekinumab in the treatment of palmoplantar pustular psoriasis - a case series of nine patients. ( 27879067 )
2016
30
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
31
Psoriatic Arthritis with Annular Pustular Psoriasis. ( 26935375 )
2016
32
Netherton Syndrome Mimicking Pustular Psoriasis: Clinical Implications and Response to Intravenous Immunoglobulin. ( 27086664 )
2016
33
Generalized Pustular Psoriasis Associated with Shock. ( 26976288 )
2016
34
Adalimumab administration after infliximab therapy is a successful treatment strategy for generalized pustular psoriasis. ( 27743397 )
2016
35
Case of generalized pustular psoriasis exacerbated during pregnancy, successfully treated with infliximab. ( 27130289 )
2016
36
Two case reports of generalized pustular psoriasis of pregnancy: Different outcomes. ( 27512494 )
2016
37
Extemporaneous Compounding of Oral Acitretin Suspension for Pediatric Patient with Generalized Pustular Psoriasis. ( 27125051 )
2016
38
Tumor Necrosis Factor-alpha Induced Protein 3 Interacting Protein 1 Gene Polymorphisms and Pustular Psoriasis in Chinese Han Population. ( 27364786 )
2016
39
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. ( 27509423 )
2016
40
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. ( 27489427 )
2016
41
Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study. ( 27106510 )
2016
42
Biologics and Pediatric Generalized Pustular Psoriasis: An Emerging Therapeutic Trend. ( 27462478 )
2016
43
Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients. ( 26589685 )
2016
44
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
45
Secukinumab in the Treatment of Palmoplantar, Nail, Scalp, and Pustular Psoriasis. ( 28439342 )
2016
46
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J). ( 27726163 )
2016
47
Pustular Psoriasis Occurring on the Striae Distensae: An Umpteenth Example of Immunocompromised Cutaneous District. ( 27688451 )
2016
48
Pustular Psoriasis Occurring on the Striae Distensae: Isotopic Phenomenon/Koebner's Phenomenon. ( 27057062 )
2016
49
Secukinumab in the treatment of generalized pustular psoriasis - a case report. ( 27231055 )
2016
50
Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab. ( 26627198 )
2016

Variations for Pustular Psoriasis

Expression for Pustular Psoriasis

Search GEO for disease gene expression data for Pustular Psoriasis.

Pathways for Pustular Psoriasis

Pathways related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 ELANE TNF
2 11.13 CARD14 TNF
4 10.3 ELANE TNF

GO Terms for Pustular Psoriasis

Biological processes related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CARD14 TNF
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.4 CARD14 TNF
3 positive regulation of MAP kinase activity GO:0043406 9.37 ELANE TNF
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.32 ELANE TNF
5 antimicrobial humoral response GO:0019730 9.26 ELANE PI3
6 negative regulation of interleukin-6 production GO:0032715 9.16 IL36RN TNF
7 negative regulation of growth of symbiont in host GO:0044130 8.96 ELANE TNF
8 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 ELANE TNF

Molecular functions related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 ELANE TNF

Sources for Pustular Psoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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