MCID: PST059
MIFTS: 36

Pustular Psoriasis malady

Categories: Rare diseases, Genetic diseases, Skin diseases, Bone diseases, Blood diseases

Aliases & Classifications for Pustular Psoriasis

Aliases & Descriptions for Pustular Psoriasis:

Name: Pustular Psoriasis 50 52 69

Classifications:



Summaries for Pustular Psoriasis

NIH Rare Diseases : 50 pustular psoriasis is a rare form of psoriasis that is characterized by widespread pustules and reddish skin. this condition can occur alone or with plaque-type psoriasis. most cases of pustular psoriasis are thought to be "multifactorial" or associated with the effects of multiple genes in combination with lifestyle and environmental factors. there are several triggers for this conditions including withdrawal from corticosteroids, exposure to various medications and/or infections. some cases of the generalized form are caused by changes (mutations) in the il36rn gene and are inherited in an autosomal recessive pattern. in severe cases, hospitalization may be required. treatment aims to alleviate the associated symptoms and may include certain medications and/or phototherapy. last updated: 11/11/2015

MalaCards based summary : Pustular Psoriasis is related to subcorneal pustular dermatosis and psoriasis 14, pustular. An important gene associated with Pustular Psoriasis is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Matrix Metalloproteinases and NF-kappa B signaling pathway. The drugs Immunoglobulins and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and neutrophil.

Wikipedia : 71 The term pustular psoriasis is used for a heterogeneous group of diseases that share pustular skin... more...

Related Diseases for Pustular Psoriasis

Diseases in the Pustular Psoriasis family:

Psoriasis 14, Pustular Psoriasis 15, Pustular

Diseases related to Pustular Psoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 subcorneal pustular dermatosis 29.7 ELANE PI3 TNF
2 psoriasis 14, pustular 12.3
3 pustulosis palmaris et plantaris 12.1
4 impetigo herpetiformis 11.7
5 psoriasis 15, pustular 11.6
6 pustulosis of palm and sole 11.2
7 psoriasis susceptibility 1 11.2
8 psoriasis 10.9
9 arthritis 10.2
10 cavitary myiasis 10.2 AP1S3 IL36RN
11 acute generalized exanthematous pustulosis 10.2
12 occupational dermatitis 10.1 IL36RN TNF
13 robin sequence with cleft mandible and limb anomalies 10.1 CARD14 IL36RN
14 papilledema 10.1 IL36RN TNF
15 psoriatic arthritis 10.1
16 acrodermatitis 10.1
17 impetigo 10.1
18 cerebellar disease 10.0 PI3 TNF
19 nephronophthisis 1, juvenile 10.0 AP1S3 IL36RN TNF
20 acute respiratory distress syndrome 10.0
21 pemphigus 10.0
22 chromoblastomycosis 10.0 ELANE TNF
23 alcoholic hepatitis 10.0 ELANE TNF
24 retinitis pigmentosa 51 10.0 ELANE TNF
25 infancy electroclinical syndrome 10.0 ELANE TNF
26 stenosis of lacrimal sac 9.9 ELANE TNF
27 acute dacryoadenitis 9.9 ELANE TNF
28 brucella suis brucellosis 9.9 ELANE PI3
29 fasciitis 9.9 ELANE TNF
30 familial renal papillary carcinoma 9.9 ELANE TNF
31 dysentery 9.9 ELANE PI3
32 spontaneous ocular nystagmus 9.9 ELANE TNF
33 atelosteogenesis ii 9.9 ELANE PI3
34 bare lymphocyte syndrome, type i 9.9 ELANE TNF
35 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 9.9 ELANE TNF
36 capillary leak syndrome 9.9
37 vasculitis 9.9
38 turner syndrome 9.9
39 acute chest syndrome 9.9 ELANE TNF
40 anogenital venereal wart 9.9 ELANE TNF
41 eating disorder 9.9 ELANE TNF
42 histiocytosis 9.8 ELANE TNF
43 rectum squamous cell carcinoma 9.8 ELANE TNF
44 rheumatoid arthritis 9.8
45 pneumonia 9.8
46 hepatitis 9.8
47 thyroiditis 9.8
48 pemphigus foliaceus 9.8
49 netherton syndrome 9.8
50 bullous pemphigoid 9.8

Graphical network of the top 20 diseases related to Pustular Psoriasis:



Diseases related to Pustular Psoriasis

Symptoms & Phenotypes for Pustular Psoriasis

Drugs & Therapeutics for Pustular Psoriasis

Drugs for Pustular Psoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4,Phase 3
2 Antibodies, Monoclonal Phase 4,Phase 3
3 Antibodies Phase 4,Phase 3
4
Acitretin Approved Phase 3 55079-83-9 6437841 5284513
5
Dimethyl fumarate Approved, Investigational Phase 3 624-49-7 637568 5271565
6
Methoxsalen Approved Phase 3 298-81-7 4114
7
Infliximab Approved Phase 3 170277-31-3
8
Tofacitinib Approved, Investigational Phase 3 477600-75-2
9
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
10
Certolizumab pegol Approved Phase 2, Phase 3 428863-50-7
11
Adalimumab Approved Phase 3 331731-18-1 16219006
12
Menthol Approved Phase 3 2216-51-5 16666
13
Ustekinumab Approved, Investigational Phase 3 815610-63-0
14 tannic acid Approved, Nutraceutical Phase 2, Phase 3
15 5-methoxypsoralen Phase 3
16 Dermatologic Agents Phase 3,Phase 2
17 Photosensitizing Agents Phase 3
18 Keratolytic Agents Phase 3,Phase 2
19 Gastrointestinal Agents Phase 3
20 Protein Kinase Inhibitors Phase 3
21 Antirheumatic Agents Phase 3,Phase 2
22 Pharmaceutical Solutions Phase 2, Phase 3
23 Immunosuppressive Agents Phase 2, Phase 3
24 Anti-Inflammatory Agents Phase 3
25
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795
26
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538
27 tyrosine Nutraceutical

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
2 Fumaric Acid Ester-PUVA Therapy Versus Acitretin -PUVA Therapy in Pustular Palmoplantar Psoriasis Unknown status NCT00811005 Phase 3
3 Study to Assess the Efficacy, Safety and Tolerability of Secukinumab in Japanese Subjects With Generalized Pustular Psoriasis (GPP) Completed NCT01952015 Phase 3
4 An Open-label, Non-controlled Study of KHK4827 in Subjects With Psoriasis Completed NCT01782937 Phase 3
5 A Phase 3 Clinical Study of KHK 4827 Completed NCT02052609 Phase 3
6 A Clinical Study of Increased Dose of TA-650 in Patients With Psoriasis Completed NCT01680159 Phase 3
7 Study to Evaluate the Efficacy of Infliximab Induction Therapy for Patients With Palmoplantar Psoriasis (PPP)(Study P04555)(COMPLETED) Completed NCT00686686 Phase 3
8 A Study To Evaluate The Effects And Safety Of Treatment, Treatment Withdrawal, Followed By Re-Treatment With CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis Completed NCT01186744 Phase 3
9 A Study to Assess Efficacy and Safety of Two Different Dose Regimens of Risankizumab Administered Subcutaneously in Japanese Subjects With Generalized Pustular Psoriasis or Erythrodermic Psoriasis Recruiting NCT03022045 Phase 3
10 A Study to Test the Efficacy and Safety of Certolizumab Pegol in Japanese Subjects With Moderate to Severe Chronic Psoriasis Recruiting NCT03051217 Phase 2, Phase 3
11 An Efficacy and Safety Study of CNTO1959 (Guselkumab) in the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis Active, not recruiting NCT02343744 Phase 3
12 Palmoplantar Pustular Psoriasis Efficacy and Safety wIth Secukinumab Active, not recruiting NCT02008890 Phase 3
13 Study to Investigate Efficacy and Safety of Adalimumab in Japanese Subjects With Generalized Pustular Psoriasis (GPP) Active, not recruiting NCT02533375 Phase 3
14 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3
15 Determination of the Efficacy and Safety of Psirelax in the Relief of the Disease in Psoriasis Completed NCT01000714 Phase 2
16 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2
17 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2
18 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Recruiting NCT03135548 Phase 2
19 BI655130 Single Dose in Generalized Pustular Psoriasis Recruiting NCT02978690 Phase 1
20 IL-17 Role in Variants of Psoriasis Completed NCT02078297
21 Role of Tyrosine Kinase Lyn and Cleaved Form by Caspases in Psoriasis Recruiting NCT01538342
22 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustular Psoriasis

Genetic Tests for Pustular Psoriasis

Anatomical Context for Pustular Psoriasis

MalaCards organs/tissues related to Pustular Psoriasis:

39
Skin, Monocytes, Neutrophil, Tongue, Bone, Thyroid, Endothelial

Publications for Pustular Psoriasis

Articles related to Pustular Psoriasis:

(show top 50) (show all 349)
id Title Authors Year
1
Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway. ( 27743912 )
2017
2
Annular pustular psoriasis in a 14-month-old girl: a therapeutic challenge. ( 27997815 )
2017
3
A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. ( 27802907 )
2017
4
Pustular Psoriasis Occurring on the Striae Distensae: Isotopic Phenomenon/Koebner's Phenomenon. ( 27057062 )
2016
5
Two case reports of generalized pustular psoriasis of pregnancy: Different outcomes. ( 27512494 )
2016
6
Certolizumab pegol, a pegylated anti-TNF-I+ antagonist, caused de novo-onset palmoplantar pustulosis followed by generalized pustular psoriasis in a patient with rheumatoid arthritis. ( 27599405 )
2016
7
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
8
Tumor Necrosis Factor-alpha Induced Protein 3 Interacting Protein 1 Gene Polymorphisms and Pustular Psoriasis in Chinese Han Population. ( 27364786 )
2016
9
Extemporaneous Compounding of Oral Acitretin Suspension for Pediatric Patient with Generalized Pustular Psoriasis. ( 27125051 )
2016
10
Generalized pustular psoriasis treated with ustekinumab. ( 27333948 )
2016
11
Pustular psoriasis eruption with dabrafenib, a BRAF inhibitor. ( 27080364 )
2016
12
Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris. ( 27152848 )
2016
13
Perianal streptococcal infection precipitating pustular psoriasis in an adult. ( 27504479 )
2016
14
Generalized Pustular Psoriasis Associated with Shock. ( 26976288 )
2016
15
Generalized pustular psoriasis associated with Turner syndrome and dilated cardiomyopathy. ( 26870904 )
2016
16
Case of generalized pustular psoriasis exacerbated during pregnancy, successfully treated with infliximab. ( 27130289 )
2016
17
Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients. ( 26589685 )
2016
18
Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions. ( 27450766 )
2016
19
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J). ( 27726163 )
2016
20
Netherton Syndrome Mimicking Pustular Psoriasis: Clinical Implications and Response to Intravenous Immunoglobulin. ( 27086664 )
2016
21
Generalized pustular psoriasis induced by systemic steroid dose reduction. ( 27828647 )
2016
22
Successful use of secukinumab in pustular psoriasis. ( 27981221 )
2016
23
Secukinumab in the treatment of generalized pustular psoriasis - a case report. ( 27231055 )
2016
24
Successful response in a case of severe pustular psoriasis after IL-1I^ inhibition. ( 27105586 )
2016
25
Correction: Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris. ( 27326461 )
2016
26
Pneumocystis jirovecii pneumonia in a patient with pustular psoriasis with an IL-36RN deficiency treated with infliximab: Case report and review of the literature. ( 27170513 )
2016
27
Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner. ( 28057979 )
2016
28
Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab. ( 26627198 )
2016
29
IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. ( 28043870 )
2016
30
Pustular Psoriasis Occurring on the Striae Distensae: An Umpteenth Example of Immunocompromised Cutaneous District. ( 27688451 )
2016
31
Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study. ( 27106510 )
2016
32
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
33
Rebound pustular psoriasis after brodalumab discontinuation. ( 27037661 )
2016
34
Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multicenter Japanese study. ( 26919410 )
2016
35
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. ( 27509423 )
2016
36
Adalimumab administration after infliximab therapy is a successful treatment strategy for generalized pustular psoriasis. ( 27743397 )
2016
37
Biologics and Pediatric Generalized Pustular Psoriasis: An Emerging Therapeutic Trend. ( 27462478 )
2016
38
Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis. ( 27489427 )
2016
39
Psoriatic Arthritis with Annular Pustular Psoriasis. ( 26935375 )
2016
40
Ustekinumab in the treatment of palmoplantar pustular psoriasis - a case series of nine patients. ( 27879067 )
2016
41
Therapeutic Efficacy of Interleukin 12/Interleukin 23 Blockade in Generalized Pustular Psoriasis Regardless of IL36RN Mutation Status. ( 27096382 )
2016
42
Generalized Pustular Psoriasis (Von Zumbusch Type) Following Renal Transplant: A Case Report. ( 27915962 )
2016
43
Pediatric pustular psoriasis with Turner's syndrome. ( 26387881 )
2015
44
Infant with generalized pustular psoriasis who responded to cyclosporin A therapy. ( 26046589 )
2015
45
Childhood generalized pustular psoriasis: longtime remission with combined infliximab and methotrexate treatment. ( 25644044 )
2015
46
A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia. ( 26955330 )
2015
47
Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature. ( 26465742 )
2015
48
Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris. ( 26203641 )
2015
49
Identification of Two Loci Associated with Generalized Pustular Psoriasis. ( 25801791 )
2015
50
IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis. ( 25458002 )
2015

Variations for Pustular Psoriasis

Expression for Pustular Psoriasis

Search GEO for disease gene expression data for Pustular Psoriasis.

Pathways for Pustular Psoriasis

Pathways related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 ELANE TNF
2 11.13 CARD14 TNF
4 10.3 ELANE TNF

GO Terms for Pustular Psoriasis

Biological processes related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CARD14 TNF
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.4 CARD14 TNF
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.37 ELANE TNF
4 positive regulation of MAP kinase activity GO:0043406 9.32 ELANE TNF
5 antimicrobial humoral response GO:0019730 9.26 ELANE PI3
6 negative regulation of interleukin-6 production GO:0032715 9.16 IL36RN TNF
7 negative regulation of growth of symbiont in host GO:0044130 8.96 ELANE TNF
8 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 ELANE TNF

Molecular functions related to Pustular Psoriasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 ELANE TNF

Sources for Pustular Psoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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