MCID: PYL005
MIFTS: 57

Pyelonephritis malady

Summaries for Pyelonephritis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Pyelonephritis (from Greek πήληξ – pyelum, meaning \"renal pelvis\", νεφρός – nephros,... more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selected targets of HNF1 and Chemokine receptors bind chemokines. The compounds uric acid and pentosidine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Pyelonephritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

pyelonephritis 8 10 44 60
unspecified pyelonephritis nos 8
pyelonephritis, unspecified 8
pyelonephritis unspecified 8
pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:11400
ICD9CM27 590.80
MeSH34 D011704
NCIt39 C34965

Related Diseases for Pyelonephritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pyelonephritis family:

Acute Pyelonephritis Chronic Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis31.7CXCR1, NAGLU, CRP
2chronic pyelonephritis31.5NAGLU, UMOD, B2M
3hypertension30.7CRP, ADM, ALB
4cystitis30.7UMOD, NAGLU
5vesicoureteral reflux30.6UMOD, NAGLU, AMBP
6hydronephrosis30.5NAGLU
7bacteriuria30.5CRP, UMOD
8hepatitis30.5UGT1A1, CXCL10
9glomerulonephritis30.5AMBP, UMOD, B2M, ALB, NAGLU
10amyloidosis30.4CRP, B2M, ALB
11diabetes mellitus30.3GOT1, FBP1, B2M, UMOD, NAGLU, AMBP
12nephrolithiasis30.2UMOD
13nephrotic syndrome30.2AMBP, ALB, B2M, NAGLU
14hepatitis a30.2GOT1
15osteomyelitis30.1CRP
16chronic kidney failure30.1AQP2, ADM, ALB, UMOD, B2M, CRP
17proteinuria30.1ALB, NAGLU, CRP, UMOD, AMBP, B2M
18pneumonia30.1ADM, CRP, CXCL10, CXCR2, NAGLU
19adenocarcinoma30.1AMBP, ADM, UGT1A1, CXCL10, CXCR1, CXCR2
20urinary tract obstruction30.0AQP2
21acute kidney failure30.0AMBP, NAGLU, ALB, UMOD, B2M
22arthritis30.0B2M, AMBP, ALB, CXCL10, CXCR2, CXCR1
23thrombocytopenia29.9ALB, GOT1
24rheumatoid arthritis29.9AMBP, B2M, CXCL10, NAGLU, NAMPT, CXCR2
25systemic lupus erythematosus29.7CRP
26kawasaki disease29.7ADM, CRP
27pancreatitis29.7GOT1, CRP, ALB
28neutropenia29.7CXCL10, CXCR1, UGT1A1
29leukemia29.7NAMPT, CXCR1, B2M
30influenza29.7CXCL10, LPXN, LGALS7
31essential hypertension29.7AQP2, ADM, ALB, NAGLU, LPXN
32myeloma29.7ALB, NAGLU, B2M, UMOD
33uremia29.7AMBP, CRP, B2M, ALB
34breast cancer29.7CXCL10, NAGLU, AMBP, UGT1A1, NAMPT, CXCR1
35hypercalcemia29.7ALB, B2M
36bronchitis29.7CRP
37xanthogranulomatous pyelonephritis11.1
38pyelitis10.4
39renal cell carcinoma10.3
40acute cystitis10.3
41urethritis10.2
42interstitial nephritis10.2
43pseudohypoaldosteronism10.2
44kidney disease10.2
45lipomatosis10.2
46perinephritis10.1
47malignant hypertension10.1
48prostatitis10.1
49tuberculosis10.1
50pyuria10.1

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Clinical Features for Pyelonephritis

About this section

Drugs & Therapeutics for Pyelonephritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Pyelonephritis

Search NIH Clinical Center for Pyelonephritis

Search CenterWatch for Pyelonephritis

Genetic Tests for Pyelonephritis

About this section

Anatomical Context for Pyelonephritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pyelonephritis:

32
Kidney, Testes, Liver, Prostate, Colon, Cortex, Spinal cord, Bone, Heart, T cells, Monocytes, Whole blood, Lymph node, Ovary, Breast, Thyroid, Lung, Spleen, Brain, B cells

Animal Models for Pyelonephritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2NAGLU, CXCR2, ALB, ADM, AQP2, UMOD
2MP:00053769.9AQP2, UMOD, CRP, B2M, HCCS, NAMPT
3MP:00053879.7UMOD, CRP, B2M, NAGLU, NAMPT, CXCR2

Publications for Pyelonephritis

About this section
Sources:
50PubMed
See all sources

Articles related to Pyelonephritis:

(show top 50)    (show all 1534)
idTitleAuthorsYear
1
Enterococcus osteomyelitis secondary to pyelonephritis. (22777580)
2013
2
Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor. (23589799)
2013
3
Bilateral emphysematous pyelonephritis. (23019407)
2012
4
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
5
Ultrasound detection of obstructive pyelonephritis due to urolithiasis in the ED. (20934827)
2011
6
The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children. (21944121)
2011
7
Adjunctive oral methylprednisolone in pediatric acute pyelonephritis alleviates renal scarring. (21844061)
2011
8
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. (21119270)
2010
9
Xanthogranulomatous pyelonephritis: an uncommon pediatric renal mass. (20151117)
2010
10
Emphysematous pyelonephritis in a renal transplant patient. (20009119)
2009
11
Subcutaneous emphysema as a clinical finding in emphysematous pyelonephritis. (20464339)
2009
12
Re: Is percutaneous drainage the new gold standard in the management of emphysematous pyelonephritis? Evidence from a systematic review: B. K. Somani, G. Nabi, P. Thorpe, J. Hussey, J. Cook, J. N'Dow and the ABACUS Research Group J Urol 2008; 179: 1844-1849. (19019388)
2009
13
Bilateral emphysematous pyelonephritis and cystitis in an ESRD patient presenting with septic shock. (19432030)
2009
14
Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis. (18800031)
2009
15
Successful treatment of bilateral emphysematous pyelonephritis in a uremic patient without nephrectomy. (19212917)
2009
16
A case of portal venous gas after extracorporeal shockwave lithotripsy and obstructive pyelonephritis. (18342210)
2008
17
Oral versus parenteral antibiotics for the initial treatment of a first episode of acute pyelonephritis in children. (18059391)
2008
18
Nephrolithiasis and pyelonephritis in two West Indian manatees (Trichechus manatus spp.). (18689658)
2008
19
Focal xanthogranulomatous pyelonephritis: success of conservative treatment. A case report. (19472811)
2008
20
The clinical impact of bacteremia in complicated acute pyelonephritis. (17031242)
2006
21
Xanthogranulomatous pyelonephritis and malacoplakia of the bladder in a middle aged female. (16736426)
2006
22
Acute pyelonephritis and renal scarring in Kuwaiti children: a follow-up study using 99mTc DMSA renal scintigraphy. (15973531)
2005
23
Inferior vena cava thrombosis due to acute pyelonephritis. (15031360)
2004
24
Long-term follow-up of women hospitalized for acute pyelonephritis. (14523764)
2003
25
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
26
Polymorphonuclear elastase as a diagnostic marker of acute pyelonephritis in children. (10654988)
2000
27
Ambulatory management of acute pyelonephritis in children. (10772296)
2000
28
Aminoglycosides do not improve the efficacy of cephalosporins for treatment of acute pyelonephritis in women. (9181655)
1997
29
Xanthogranulomatous pyelonephritis--an unusual renal disease in childhood. (8640064)
1996
30
Cytokine and lymphocyte activation during experimental acute pyelonephritis. (7618233)
1995
31
Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. (7696107)
1994
32
Xanthogranulomatous pyelonephritis with multiple cutaneous fistulae. (12834560)
1994
33
Immunity and the possibilities for immunomodulation in acute pyelonephritis]. (1755120)
1991
34
Xanthogranulomatous pyelonephritis. (2819382)
1989
35
Evaluation of 99mtechnetium-dimercapto-succinic acid renal scans in experimental acute pyelonephritis in piglets. (2846898)
1988
36
Ultrasonography and needle aspiration in diagnosis of xanthogranulomatous pyelonephritis. (3544457)
1987
37
Xanthogranulomatous pyelonephritis in children and adults. (3594095)
1987
38
Xanthogranulomatous pyelonephritis. A clinico-pathological study with special reference to pathogenesis. (7368938)
1980
39
Arterial encasement in xanthogranulomatous pyelonephritis. (674627)
1978
40
Long-term study of humoral immune response in patients with chronic pyelonephritis. (788977)
1976
41
Diagnostic value of ceruloplasmin, haptoglobin and sialic acid in chronic pyelonephritis. (965209)
1976
42
Experimentally induced chronic pyelonephritis using bacterial antigen and its prevention with immunosuppression. (4597433)
1974
43
Xanthogranulomatous pyelonephritis. Unusual clinical presentations. (4768745)
1973
44
Ureteric reflux 1973: chronic pyelonephritis v. reflux nephropathy. (4580015)
1973
45
Maximum tubular reabsorption of water. A preliminary study of renal concentrating capacity in children with chronic pyelonephritis. (5455519)
1970
46
Xanthogranulomatous pyelonephritis: 2 case reports. (5343473)
1969
47
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. II. EFFECT OF REPETITIVE INFECTION. (14223578)
1964
48
ROLE OF CHRONIC PYELONEPHRITIS IN THE PRODUCTION OF EXPERIMENTAL HYDRONEPHROSIS. (14226454)
1964
49
LONG-TERM FOLLOW-UP ON THE NITROFURANTOIN TREATMENT OF PATIENTS WITH CHRONIC PYELONEPHRITIS. (14288006)
1964
50
Long-term study of blood pressure in rabbits with unilateral chronic pyelonephritis or unilateral hydronephrosis. (14488507)
1962

Genetic Variations for Pyelonephritis

About this section

Expression for genes affiliated with Pyelonephritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for genes affiliated with Pyelonephritis

About this section
Sources:
12EMD Millipore, 53Reactome
See all sources

Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ALB, CRP, UMOD
210.3CXCL10, CXCR1, CXCR2

Compounds for genes affiliated with Pyelonephritis

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.8B2M, UMOD
2pentosidine4410.8ALB, B2M
3iopentol4410.8ALB, NAGLU, B2M
4p-aminohippuric acid4410.8B2M, NAGLU, ALB
5mannitol44 1111.8ALB, NAGLU, CRP
6amikacin4410.8AMBP, B2M, NAGLU
7gamma globulin4410.8B2M, CRP, ALB
8endotoxin4410.7ADM, CXCR2
9vitamin a44 11 2412.7AMBP, NAGLU
1099mtc-dmsa4410.7AMBP, CRP, B2M, NAGLU
11dmsa4410.7CRP, AMBP, B2M, NAGLU
12iohexol4410.7AMBP, ALB, B2M, NAGLU
13calcium oxalate4410.7AMBP, UMOD, NAGLU
14inulin4410.7NAGLU, ALB, B2M, AMBP
15sevoflurane44 1111.7NAGLU, ALB, B2M
16perindopril44 49 1112.7NAGLU, ALB, CRP
17cxcl62810.7CXCR2, CXCR1
18cxcl82810.7CXCR2, CXCR1
19neopterin4410.7B2M, CRP, NAGLU, CXCL10
20[125i]cxcl8 (human)2810.7CXCR1, CXCR2
21losartan44 49 28 1113.7CRP, ADM, NAGLU, ALB, UGT1A1
22cxcl12810.7CXCR2, CXCR1
23mercury4410.7NAGLU, AQP2, AMBP
24potassium44 11 2412.7AMBP, NAGLU, ADM, AQP2
25urea44 11 2412.6B2M, AQP2, ALB, NAGLU, AMBP, UMOD
26hydrochlorothiazide44 49 28 11 2414.6CRP, ALB, AQP2
27polysulfone4410.6B2M, CRP, ALB
28homocysteine44 2411.6CRP, ALB, NAGLU, ADM
29aspartate4410.6NAGLU, ALB, B2M, UGT1A1, AMBP
30nh4cl4410.6AMBP, B2M
31sodium44 2411.6ADM, UMOD, B2M, NAGLU, ALB, AMBP
32lactate4410.6ALB, CRP, AMBP, B2M, ADM, NAGLU
33enalapril44 49 1112.6AMBP, NAGLU, ALB
34polyether sulfone4410.5ALB, B2M
35groalpha4410.5CXCR1, CXCR2, CXCL10
36cholesterol44 28 11 2413.5NAGLU, B2M, CRP, LPXN, UGT1A1, CXCL10
37creatinine4410.5AMBP, UMOD, CRP, B2M, NAGLU, NAMPT
38cysteine4410.5UMOD, B2M, ADM, CXCR1, CXCR2, NAGLU
39fibrinogen4410.4AMBP, NAMPT, CXCR2, ALB, CRP
40citrate4410.4ALB, NAGLU, CRP, UMOD
41desmopressin44 59 28 1113.4B2M, AQP2, NAGLU
42retinoic acid44 2411.4ADM, CXCR1, B2M, UGT1A1, LGALS7, CXCL10
43alanine4410.4CRP, UGT1A1, AMBP, B2M, NAGLU, CXCL10
44lipid4410.4CRP, LPXN, AQP2, AMBP, CXCL10, ALB
45glucose4410.3NAGLU, FBP1, AQP2, AMBP, UMOD, LPXN
46calcium44 49 11 2413.3UMOD, CRP, NAGLU, B2M, CXCL10, CXCR1
47nitroglycerin44 1111.3B2M, ADM, CRP
48hyaluronic acid44 2411.3B2M, NAGLU, ALB, AMBP
49ifosfamide44 1111.2AMBP, B2M, NAGLU
50steroid449.9NAGLU, AMBP, UGT1A1, B2M, ADM, AQP2

GO Terms for genes affiliated with Pyelonephritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1CPN1, ADM, ALB, CXCL10, B2M, CRP

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.6CXCR1, CXCR2
2response to starvationGO:04259410.5UGT1A1, ADM, AQP2
3heme catabolic processGO:04216710.5UGT1A1, AMBP
4receptor internalizationGO:03162310.5CXCR2, CXCR1, ADM
5response to lipopolysaccharideGO:03249610.5AQP2, ADM, CXCL10, UGT1A1
6response to glucocorticoid stimulusGO:05138410.4GOT1, ADM, CPN1
7dendritic cell chemotaxisGO:00240710.4CXCR1, CXCR2
8female pregnancyGO:00756510.3AQP2, ADM, AMBP
9agingGO:00756810.2CRP, ADM, AQP2
10inflammatory responseGO:00695410.0CXCL10, CXCR1, CXCR2, CRP

Molecular functions related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.4CXCR1, CXCR2
2interleukin-8 receptor activityGO:00491810.1CXCR1, CXCR2

Products for genes affiliated with Pyelonephritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyelonephritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet