MCID: PYL005
MIFTS: 54

Pyelonephritis malady

Nephrological diseases category
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Summaries for Pyelonephritis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pyelonephritis /pa??lo?n??fra?t?s/ (from Greek ????? ? pyelum, meaning \"renal pelvis\", ?????? ?... more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selenium Pathway and Selected targets of HNF1. The compounds amikacin and tobramycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related mouse phenotypes are immune system and renal/urinary system.

Aliases & Classifications for Pyelonephritis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

pyelonephritis 8 10 45 62
unspecified pyelonephritis nos 8
pyelonephritis, unspecified 8
pyelonephritis unspecified 8
pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:11400
MeSH35 D011704
NCIt40 C34965
ICD9CM27 590.80

Related Diseases for Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

Acute Pyelonephritis Chronic Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis31.8NAGLU, CXCR1, CRP
2chronic pyelonephritis31.6B2M, NAGLU, UMOD
3cystitis30.9UMOD, NAGLU
4vesicoureteral reflux30.8UMOD, NAGLU
5hypertension30.8CRP, ALB, CALCA
6bacteriuria30.7CRP, UMOD
7nephritis30.5ALB, B2M
8glomerulonephritis30.5B2M, NAGLU, UMOD, ALB
9amyloidosis30.4B2M, ALB, CRP
10sepsis30.3CRP, ALB, CALCA, CXCR1
11amyloidosis, secondary30.3CRP, B2M
12nephrotic syndrome30.2ALB, NAGLU, B2M
13tuberculosis30.2CXCR1, ALB, CRP
14diabetes mellitus30.2B2M, NAGLU, UMOD, CALCA, ALB, CRP
15proteinuria30.1B2M, NAGLU, UMOD, ALB, CRP
16rheumatoid arthritis29.9CRP, CXCR1, NAGLU, B2M
17arthritis29.9B2M, CXCR1, CALCA, ALB, CRP
18lupus nephritis29.8ALB, NAGLU
19urinary tract obstruction29.8B2M, NAGLU, UMOD
20hyperhomocysteinemia29.8ALB, CRP
21hyperparathyroidism29.8ALB, CALCA
22uremia29.7CRP, ALB, B2M
23hypercalcemia29.7ALB, CALCA, B2M
24pancreatitis29.7CRP, ALB
25acute kidney failure29.7B2M, NAGLU, UMOD, ALB
26myeloma29.7B2M, NAGLU, UMOD, ALB
27chronic kidney failure29.6B2M, NAGLU, UMOD, ALB, CRP
28breast cancer29.6NAGLU, CXCR1, CALCA, ALB
29xanthogranulomatous pyelonephritis11.2
30pyelitis10.4
31hydronephrosis10.4
32renal cell carcinoma10.4
33hepatitis10.3
34bacteremia10.3
35urethritis10.3
36interstitial nephritis10.3
37septic shock10.3
38blindness10.3
39pseudohypoaldosteronism10.2
40lipomatosis10.2
41horseshoe kidney10.2
42perinephritis10.2
43acute cystitis10.2
44malignant hypertension10.2
45prostatitis10.2
46malakoplakia10.2
47pyuria10.1
48nephrolithiasis10.1
49adenocarcinoma10.1
50osteomyelitis10.1

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Symptoms for Pyelonephritis

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Drugs & Therapeutics for Pyelonephritis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pyelonephritis

Search NIH Clinical Center for Pyelonephritis

Genetic Tests for Pyelonephritis

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Anatomical Context for Pyelonephritis

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33MalaCards
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MalaCards organs/tissues related to Pyelonephritis:

33
Kidney, Testes, Liver, Prostate, Colon, Cortex, Spinal cord, Bone, Brain, T cells, Monocytes, Whole blood, Lymph node, Ovary, Breast, Thyroid, Lung, Spleen, B cells

Animal Models for Pyelonephritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pyelonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2CRP, UMOD, NAGLU, CPN1, B2M
2MP:00053678.1ALB, CALCA, UMOD, NAGLU

Publications for Pyelonephritis

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52PubMed
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Articles related to Pyelonephritis:

(show top 50)    (show all 1523)
idTitleAuthorsYear
1
Emphysematous Pyelonephritis-a Rare Surgical Emergency Presenting to the Physician: A Case Report and Literature Review. (24426588)
2013
2
Urinary concentration of cytokines in children with acute pyelonephritis. (23389820)
2013
3
Mouse model for pyelonephritis. (23564687)
2013
4
The effects of anemia on pregnancy outcome in patients with pyelonephritis. (24369448)
2013
5
Pyelonephritis in pregnancy. How adequate is empirical treatment? (23546459)
2013
6
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. (23052650)
2013
7
Treatment of pyelonephritis caused by extended-spectrum I^-lactamase-producing Enterobacteriaceae in children. (23274920)
2013
8
Genotypic Analysis of E. coli Strains Isolated from Patients with Cystitis and Pyelonephritis. (22997556)
2012
9
The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture. (21507269)
2011
10
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
11
Five patients with emphysematous pyelonephritis. (21525582)
2011
12
Emphysematous pyelonephritis and pneumo-vena cava. (21293779)
2010
13
Pharmacotherapy of lower urinary tract infections and pyelonephritis in children. (19663608)
2009
14
A rare association of emphysematous pyelonephritis with unrecognized diabetes and polycystic kidney. (20352007)
2009
15
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. (18828054)
2008
16
A case of portal venous gas after extracorporeal shockwave lithotripsy and obstructive pyelonephritis. (18342210)
2008
17
Antibiotics for acute pyelonephritis in children. (17943796)
2007
18
Emphysematous pyelonephritis in a diabetic patient with pelvic-ureteric stone. (18705456)
2007
19
Some current aspects of diagnosis of calculous pyelonephritis]. (17471991)
2007
20
Renal parenchymal malacoplakia: a different stage of xanthogranulomatous pyelonephritis? (17618870)
2007
21
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
22
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
23
Clarithromycin: immunomodulatory therapy of experimental sepsis and acute pyelonephritis by Escherichia coli. (15764190)
2005
24
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
25
Successful medical treatment of emphysematous pyelonephritis. (17914710)
2004
26
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
27
Xanthogranulomatous pyelonephritis: urinary and fine needle aspiration cytology. (9684612)
1998
28
Focal xanthogranulomatous pyelonephritis in a teenager. (9717648)
1998
29
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
30
Xanthogranulomatous pyelonephritis in pediatric patients. (7752369)
1995
31
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
32
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
33
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
34
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
35
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
36
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986
37
Acute pyelonephritis in pregnancy. (3791931)
1986
38
Xanthogranulomatous pyelonephritis in children. (3968740)
1985
39
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
40
Xanthogranulomatous pyelonephritis with bilharzial ureteric obstruction. (6653472)
1983
41
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
42
Peripartum hepatic dysfunction and xanthogranulomatous pyelonephritis. (4576472)
1973
43
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
44
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
45
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
46
XANTHOGRANULOMATOUS PYELONEPHRITIS. (14134284)
1963
47
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
48
CLINICAL pathologic conference: acute and subacute glomerulonephritis with acute pyelonephritis. (13061782)
1953
49
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
50
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950

Variations for Pyelonephritis

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Expression for genes affiliated with Pyelonephritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for genes affiliated with Pyelonephritis

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50PathCards, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway38
9.2CRP, ALB
28.8CRP, ALB, UMOD

Compounds for genes affiliated with Pyelonephritis

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1amikacin459.8B2M, NAGLU
2tobramycin459.8NAGLU, B2M
3fosfomycin459.8NAGLU, B2M
4calcium oxalate459.8UMOD, NAGLU
5aluminium45 1110.7B2M, NAGLU
6mesna459.7B2M, NAGLU
799mtc-dmsa459.5B2M, NAGLU, CRP
8polyether sulfone459.4ALB, B2M
9neopterin459.4NAGLU, B2M, CRP
10fluoride459.3CALCA, B2M, NAGLU
11aopp459.3CRP, ALB
1251-cr-edta459.3B2M, ALB
13pamidronate45 51 1111.3CALCA, CRP, B2M
14pmma459.3CRP, CALCA, B2M
15perindopril45 51 1111.3NAGLU, CRP, ALB
16nitroglycerin45 1110.2B2M, CALCA, CRP
17isoflurane51 45 1111.2NAGLU, ALB, CALCA
18furosemide45 61 29 51 24 1114.2ALB, CALCA, NAGLU
19icodextrin45 1110.1B2M, ALB
20losartan45 51 29 1112.1CRP, ALB, NAGLU
21iopentol459.1ALB, NAGLU, B2M
22p-aminohippuric acid459.1ALB, NAGLU, B2M
23inulin459.1B2M, NAGLU, ALB
24iohexol459.1ALB, B2M, NAGLU
25fosinopril45 1110.1ALB, CRP
26sevoflurane51 45 1111.1B2M, ALB, NAGLU
27calcium carbonate459.0CALCA, B2M
28gamma globulin459.0ALB, CRP, B2M
29pentosidine459.0B2M, ALB, CRP
30dmsa459.0CRP, NAGLU, B2M, CALCA
31polysulfone459.0CRP, B2M, ALB
32vitamin b12458.9ALB, B2M, CRP
33citrate458.9ALB, CRP, UMOD, NAGLU
34captopril45 61 51 29 1112.9B2M, CALCA, ALB
35homocysteine45 249.9NAGLU, ALB, CRP
36urea45 24 1110.7ALB, NAGLU, B2M, UMOD
37mannitol45 119.6ALB, CRP, NAGLU, B2M
38vitamin a45 24 1110.6NAGLU, ALB, CRP, B2M
39phosphorus458.6ALB, CALCA, NAGLU, B2M
40vitamin d458.5NAGLU, ALB, CALCA, B2M
4125-hydroxyvitamin d458.5CRP, ALB, B2M, CALCA
42sodium45 249.5ALB, NAGLU, B2M, UMOD
43iron45 249.5NAGLU, CRP, ALB, B2M
44uric acid45 249.3NAGLU, B2M, ALB, UMOD, CRP
45aspartate458.3CRP, ALB, NAGLU, B2M
46cysteine458.2NAGLU, CXCR1, ALB, UMOD, B2M
47glucose458.2CRP, ALB, UMOD, B2M, NAGLU
48lactate458.1CRP, ALB, CALCA, NAGLU, B2M
49creatinine457.8ALB, CALCA, UMOD, NAGLU, B2M, CRP
50calcium45 51 24 1110.3ALB, CALCA, UMOD, CXCR1, CRP, NAGLU

GO Terms for genes affiliated with Pyelonephritis

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16Gene Ontology
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Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.3ALB, UMOD, NAGLU, B2M
2extracellular regionGO:0055767.8B2M, CALCA, ALB, CRP
3extracellular spaceGO:0056157.1CRP, ALB, CALCA, UMOD, CPN1, B2M

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor internalizationGO:0316239.4CALCA, CXCR1
2response to organic substanceGO:0100339.3ALB, UMOD
3inflammatory responseGO:0069549.1CRP, CALCA, CXCR1
4retina homeostasisGO:0018958.7ALB, B2M

Products for genes affiliated with Pyelonephritis

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  • Antibodies
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Sources for Pyelonephritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet