MCID: PYL005
MIFTS: 51

Pyelonephritis malady

Summaries for Pyelonephritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pyelonephritis (from Greek πήληξ – pyelum, meaning \"renal pelvis\", νεφρός – nephros,... more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and vesicoureteral reflux. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selected targets of HNF1 and Chemokine receptors bind chemokines. The compounds uric acid and pentosidine have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Pyelonephritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

pyelonephritis 8 10 45 61
unspecified pyelonephritis nos 8
pyelonephritis, unspecified 8
pyelonephritis unspecified 8
pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:11400
ICD9CM27 590.80
MeSH35 D011704
NCIt40 C34965

Related Diseases for Pyelonephritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pyelonephritis family:

acute pyelonephritis chronic pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis31.8CRP, NAGLU, CXCR1
2vesicoureteral reflux30.6NAGLU, UMOD, AMBP
3hydronephrosis30.5NAGLU
4bacteriuria30.5CRP, UMOD
5nephritis30.5B2M, ALB
6amyloidosis30.4CRP, B2M, ALB
7sepsis30.4AMBP, CRP, NAMPT, CXCR2, CXCR1, ALB
8septic shock30.4AMBP, CRP, ADM
9nephrolithiasis30.3UMOD
10amyloidosis, secondary30.2CRP, B2M
11adenocarcinoma30.2AMBP, UGT1A1, CXCR2, CXCR1, CXCL10, ADM
12acute kidney failure30.1AMBP, UMOD, B2M, NAGLU, ALB
13arthritis30.1AMBP, CRP, B2M, CXCR2, CXCR1, CXCL10
14thrombocytopenia30.0GOT1, ALB
15urinary tract obstruction29.7AQP2
16systemic lupus erythematosus29.7CRP
17lupus nephritis29.7ALB, NAGLU
18kawasaki disease29.7ADM, CRP
19hepatitis c29.7ALB, GOT1, CXCL10
20uremia29.7AMBP, CRP, B2M, ALB
21hypercalcemia29.7ALB, B2M
22bronchitis29.7CRP
23xanthogranulomatous pyelonephritis11.2
24acute cystitis10.4
25bacteremia10.3
26n syndrome10.3
27pseudohypoaldosteronism10.2
28horseshoe kidney10.2
29tuberculosis10.2
30malakoplakia10.2
31pyuria10.1
32nephrosclerosis10.1
33adult xanthogranuloma10.1
34klebsiella10.1
35renal glycosuria10.1
36necrotizing fasciitis10.1
37kidney hypertrophy10.1
38polycystic kidney disease10.1
39renal tuberculosis10.1
40autosomal dominant disease10.1
41urethral obstruction10.1
42polycystic kidney disease, autosomal dominant10.1
43amyloidosis, renal10.1
44congenital hydronephrosis10.1
45renal dysplasia10.1
46anuria10.0
47diabetic ketoacidosis10.0
48cystitis cystica10.0
49adult respiratory distress syndrome10.0
50cystinuria10.0

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Clinical Features for Pyelonephritis

Drugs & Therapeutics for Pyelonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Pyelonephritis

Search NIH Clinical Center for Pyelonephritis

Search CenterWatch for Pyelonephritis

Genetic Tests for Pyelonephritis

Anatomical Context for Pyelonephritis

Animal Models for Pyelonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pyelonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2AQP2, ADM, ALB, CXCR2, NAGLU, UMOD
2MP:00053769.9CXCL10, AQP2, ALB, CXCR2, NAMPT, HCCS
3MP:00053879.7CPN1, UMOD, ADM, CXCL10, CXCR2, NAMPT

Publications for Pyelonephritis

Sources:
51PubMed
See all sources

Articles related to Pyelonephritis:

(show top 50)    (show all 1535)
idTitleAuthorsYear
1
Pyelonephritis: what are the present day causative organisms and antibiotic susceptibilities? (23573984)
2013
2
Acute kidney injury due to tubular intraluminal monoclonal light chain crystals mimicking acute pyelonephritis. (24152144)
2013
3
Diagnostic usefulness of procalcitonin as a marker of bacteremia in patients with acute pyelonephritis. (23772894)
2013
4
Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. (22291112)
2012
5
Empirical use of ciprofloxacin for acute uncomplicated pyelonephritis caused by Escherichia coli in communities where the prevalence of fluoroquinolone resistance is high. (22391544)
2012
6
Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections. (22327887)
2012
7
Acute pyelonephritis in adults: a case series of 223 patients. (22344777)
2012
8
Laboratory diagnostics of renal function in an experimental model of ascending pyelonephritis with high-virulent Escherichia coli. (23697213)
2012
9
Laparoscopic nephrectomy for xanthogranulomatous pyelonephritis--are there predictive factors for success? (22948458)
2012
10
Clinical significance of periportal tracking as an extrarenal manifestation of acute pyelonephritis. (21125400)
2011
11
Pyelonephritis (acute) in non-pregnant women. (21477395)
2011
12
Are oral antibiotics equivalent to intravenous antibiotics for the initial management of pyelonephritis in children? (21358894)
2010
13
Xanthogranulomatous pyelonephritis. (20224317)
2010
14
Diagnosing Acute Pyelonephritis with CT, Tc-DMSA SPECT, and Doppler Ultrasound: A Comparative Study. (20428429)
2010
15
Dynamic magnetic resonance imaging in acute pyelonephritis. (19902327)
2010
16
Pyelonephritis: radiologic-pathologic review. (18203942)
2008
17
Emphysematous pyelonephritis in a diabetic patient with pelvic-ureteric stone. (18705456)
2007
18
Initial presentation of scintigraphic changes during the first episode of acute pyelonephritis in children: simultaneous evaluation with MAG3 and DMSA. (17690790)
2007
19
Emphysematous pyelonephritis in dialysis patient after embolization of failed allograft. (17826516)
2007
20
Identification and pretherapy susceptibility of pathogens in patients with complicated urinary tract infection or acute pyelonephritis enrolled in a clinical study in the United States from November 2004 through April 2006. (18042477)
2007
21
Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis. (15643259)
2005
22
Xanthogranulomatous pyelonephritis with nephrocutanous fistula and coexisting renal replacement lipomatosis: the report of a rare case. (16153545)
2005
23
MRI and CT features in two unusual cases of xanthogranulomatous pyelonephritis. (9717630)
1998
24
Focal xanthogranulomatous pyelonephritis presenting as a renal tumor with vena caval thrombus. (9628618)
1998
25
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
26
Xanthogranulomatous pyelonephritis mimicking malignant disease: is preservation of the kidney possible? (9238126)
1997
27
Xanthogranulomatous pyelonephritis, the gatekeeper's dilemma: a contemporary look at an old problem. (7879331)
1995
28
Emphysematous pyelonephritis with resultant emphysematous cholecystitis secondary to hematogenous dissemination. (7787725)
1995
29
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
30
Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli. (7906204)
1994
31
Urethral obstruction of 6 hours or less causes bacteriuria, bacteremia, and pyelonephritis in mice challenged with "nonuropathogenic" Escherichia coli. (8335372)
1993
32
The sensitivity of renal scintigraphy and sonography in detecting nonobstructive acute pyelonephritis. (1640534)
1992
33
Renal parenchymal malakoplakia. Histologic spectrum and its relationship to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis. (2919720)
1989
34
The intravenous pyelogram in acute pyelonephritis. (3052346)
1988
35
Xanthogranulomatous pyelonephritis. A reappraisal and immunohistochemical study. (3345125)
1988
36
One or three weeks' treatment of acute pyelonephritis? A double-blind comparison, using a fixed combination of pivampicillin plus pivmecillinam. (3287839)
1988
37
Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (3912177)
1985
38
P fimbriated Escherichia coli in adults with acute pyelonephritis. (2863315)
1985
39
Immunopathology of the glomerular changes in chronic pyelonephritis. (386707)
1979
40
Xanthogranulomatous pyelonephritis in a three-year-old male. (4329773)
1971
41
The epidemiology of urinary infections in Hiroshima, Japan and their relation to blood pressure levels and chronic pyelonephritis. (5820487)
1969
42
Acute pyelonephritis during pregnancy with anuria, septicemia and thrombocytopenia. (5655841)
1968
43
The problem of chronic pyelonephritis. (5342129)
1966
44
Problems of chronic pyelonephritis. (13974947)
1963
45
Reflux as a cause of hydronephrosis and chronic pyelonephritis. (14450229)
1962
46
Chronic pyelonephritis. (14454413)
1962
47
Long-term treatment of chronic pyelonephritis. (13940418)
1962
48
Pyelitis, an important factor in the pathogenesis of retrograde pyelonephritis. (13683129)
1961
49
Chronic pyelonephritis in children. (13194643)
1954
50
Duodenal obstruction caused by chronic pyelonephritis and hydronephrosis. (21014787)
1946

Genetic Variations for Pyelonephritis

Expression for genes affiliated with Pyelonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for genes affiliated with Pyelonephritis

Sources:
12EMD Millipore, 54Reactome
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Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ALB, CRP, UMOD
210.3CXCL10, CXCR1, CXCR2

Compounds for genes affiliated with Pyelonephritis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.8B2M, UMOD
2pentosidine4510.8ALB, B2M
3iopentol4510.8ALB, NAGLU, B2M
4p-aminohippuric acid4510.8B2M, NAGLU, ALB
5mannitol45 1111.8ALB, NAGLU, CRP
6amikacin4510.8AMBP, B2M, NAGLU
7gamma globulin4510.8B2M, CRP, ALB
8endotoxin4510.7ADM, CXCR2
9vitamin a45 11 2412.7AMBP, NAGLU
1099mtc-dmsa4510.7AMBP, CRP, B2M, NAGLU
11dmsa4510.7CRP, AMBP, B2M, NAGLU
12iohexol4510.7AMBP, ALB, B2M, NAGLU
13calcium oxalate4510.7AMBP, UMOD, NAGLU
14inulin4510.7NAGLU, ALB, B2M, AMBP
15sevoflurane45 1111.7NAGLU, ALB, B2M
16perindopril45 50 1112.7NAGLU, ALB, CRP
17cxcl62910.7CXCR2, CXCR1
18cxcl82910.7CXCR2, CXCR1
19neopterin4510.7B2M, CRP, NAGLU, CXCL10
20[125i]cxcl8 (human)2910.7CXCR1, CXCR2
21losartan45 50 29 1113.7CRP, ADM, NAGLU, ALB, UGT1A1
22cxcl12910.7CXCR2, CXCR1
23mercury4510.7NAGLU, AQP2, AMBP
24potassium45 11 2412.7AMBP, NAGLU, ADM, AQP2
25urea45 11 2412.6B2M, AQP2, ALB, NAGLU, AMBP, UMOD
26hydrochlorothiazide45 50 29 11 2414.6CRP, ALB, AQP2
27polysulfone4510.6B2M, CRP, ALB
28homocysteine45 2411.6CRP, ALB, NAGLU, ADM
29aspartate4510.6NAGLU, ALB, B2M, UGT1A1, AMBP
30nh4cl4510.6AMBP, B2M
31sodium45 2411.6ADM, UMOD, B2M, NAGLU, ALB, AMBP
32lactate4510.6ALB, CRP, AMBP, B2M, ADM, NAGLU
33enalapril45 50 1112.6AMBP, NAGLU, ALB
34polyether sulfone4510.5ALB, B2M
35groalpha4510.5CXCR1, CXCR2, CXCL10
36cholesterol45 29 11 2413.5NAGLU, B2M, CRP, LPXN, UGT1A1, CXCL10
37creatinine4510.5AMBP, UMOD, CRP, B2M, NAGLU, NAMPT
38cysteine4510.5UMOD, B2M, ADM, CXCR1, CXCR2, NAGLU
39fibrinogen4510.4AMBP, NAMPT, CXCR2, ALB, CRP
40citrate4510.4ALB, NAGLU, CRP, UMOD
41desmopressin45 60 29 1113.4B2M, AQP2, NAGLU
42retinoic acid45 2411.4ADM, CXCR1, B2M, UGT1A1, LGALS7, CXCL10
43alanine4510.4CRP, UGT1A1, AMBP, B2M, NAGLU, CXCL10
44lipid4510.4CRP, LPXN, AQP2, AMBP, CXCL10, ALB
45glucose4510.3NAGLU, FBP1, AQP2, AMBP, UMOD, LPXN
46calcium45 50 11 2413.3UMOD, CRP, NAGLU, B2M, CXCL10, CXCR1
47nitroglycerin45 1111.3B2M, ADM, CRP
48hyaluronic acid45 2411.3B2M, NAGLU, ALB, AMBP
49ifosfamide45 1111.2AMBP, B2M, NAGLU
50steroid459.9NAGLU, AMBP, UGT1A1, B2M, ADM, AQP2

GO Terms for genes affiliated with Pyelonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1CPN1, ADM, ALB, CXCL10, B2M, CRP

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.6CXCR2, CXCR1
2receptor internalizationGO:03162310.5CXCR2, CXCR1, ADM
3response to starvationGO:04259410.5AQP2, ADM, UGT1A1
4heme catabolic processGO:04216710.5AMBP, UGT1A1
5response to lipopolysaccharideGO:03249610.5ADM, CXCL10, UGT1A1, AQP2
6response to glucocorticoid stimulusGO:05138410.4ADM, CPN1, GOT1
7dendritic cell chemotaxisGO:00240710.4CXCR2, CXCR1
8female pregnancyGO:00756510.3AQP2, ADM, AMBP
9agingGO:00756810.2AQP2, ADM, CRP
10inflammatory responseGO:00695410.0CRP, CXCR2, CXCR1, CXCL10

Molecular functions related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.4CXCR1, CXCR2
2interleukin-8 receptor activityGO:00491810.1CXCR1, CXCR2

Products for genes affiliated with Pyelonephritis

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Sources for Pyelonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet