MCID: PYL005
MIFTS: 55

Pyelonephritis malady

Nephrological diseases category
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Summaries for Pyelonephritis

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Wikipedia:65 Pyelonephritis /pa??lo?n??fra?t?s/ (from Greek ?????|? p more...

MalaCards based summary: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selenium Pathway and Selected targets of HNF1. The compounds amikacin and tobramycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related mouse phenotypes are immune system and renal/urinary system.

Aliases & Classifications for Pyelonephritis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
See all sources

Pyelonephritis, Aliases & Descriptions:

Name: Pyelonephritis 8 10 44 62
Unspecified Pyelonephritis Nos 8
Pyelonephritis, Unspecified 8
 
Pyelonephritis Unspecified 8
Pyelonephritis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:11400
NCIt39 C34965
MeSH34 D011704
ICD9CM27 590.80

Related Diseases for Pyelonephritis

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Diseases in the Pyelonephritis family:

Acute Pyelonephritis Chronic Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis32.0NAGLU, CXCR1, CRP
2chronic pyelonephritis31.8NAGLU, UMOD, B2M
3cystitis31.3UMOD, NAGLU
4vesicoureteral reflux31.2UMOD, NAGLU
5bacteriuria31.1UMOD, CRP
6nephrolithiasis30.8NAGLU, UMOD
7hypertension30.6CRP, CALCA, ALB
8amyloidosis, secondary30.5CRP, B2M
9nephritis30.4B2M, ALB
10amyloidosis30.3ALB, CRP, B2M
11glomerulonephritis30.2UMOD, NAGLU, B2M, ALB
12tuberculosis30.2CRP, CXCR1, ALB
13nephrotic syndrome30.1NAGLU, ALB, B2M
14lupus nephritis29.9ALB, NAGLU
15urinary tract obstruction29.9UMOD, NAGLU, B2M
16hyperhomocysteinemia29.8CRP, ALB
17hyperparathyroidism29.8CALCA, ALB
18sepsis29.8ALB, CRP, CALCA, CXCR1
19rheumatoid arthritis29.8CRP, CXCR1, NAGLU, B2M
20type 2 diabetes mellitus29.7NAGLU, ALB, CRP
21acute kidney failure29.6NAGLU, UMOD, ALB, B2M
22proteinuria29.5CRP, UMOD, NAGLU, B2M, ALB
23uremia29.5CRP, ALB, B2M
24hypercalcemia29.5ALB, CALCA, B2M
25pancreatitis29.5ALB, CRP
26diabetes mellitus29.4ALB, CRP, CALCA, UMOD, NAGLU, B2M
27myeloma29.4NAGLU, UMOD, ALB, B2M
28arthritis29.3B2M, CXCR1, CALCA, ALB, CRP
29chronic kidney failure29.1CRP, ALB, B2M, UMOD, NAGLU
30breast cancer29.1NAGLU, ALB, CALCA, CXCR1
31xanthogranulomatous pyelonephritis11.2
32renal cell carcinoma10.4
33pyelitis10.4
34hydronephrosis10.4
35osteitis fibrosa10.4B2M
36hepatitis10.4
37bacteremia10.4
38nephrocalcinosis10.3NAGLU, UMOD
39hepatorenal syndrome10.3ALB
40urethritis10.3
41interstitial nephritis10.3
42septic shock10.3
43blindness10.3
44pseudohypoparathyroidism10.3CALCA, NAGLU
45hypoparathyroidism10.3NAGLU, CALCA
46pseudohypoaldosteronism10.2
47lipomatosis10.2
48horseshoe kidney10.2
49urinary system disease10.2B2M, NAGLU
50acute kidney tubular necrosis10.2B2M, NAGLU

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Symptoms for Pyelonephritis

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Drugs & Therapeutics for Pyelonephritis

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Drug clinical trials:

Search ClinicalTrials for Pyelonephritis

Search NIH Clinical Center for Pyelonephritis

Genetic Tests for Pyelonephritis

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Anatomical Context for Pyelonephritis

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MalaCards organs/tissues related to Pyelonephritis:

32
Kidney, Testes, Liver, Colon, Prostate, Cortex, Spinal cord, Neutrophil, Bone, Lung, Whole blood, Lymph node, Spleen, Brain, Heart, Thyroid, Breast, Ovary, Monocytes, T cells, B cells, Endothelial

Animal Models for Pyelonephritis or affiliated genes

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MGI Mouse Phenotypes related to Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2CRP, UMOD, NAGLU, CPN1, B2M
2MP:00053678.1ALB, CALCA, UMOD, NAGLU

Publications for Pyelonephritis

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Articles related to Pyelonephritis:

(show top 50)    (show all 1563)
idTitleAuthorsYear
1
The efficacy of non-carbapenem antibiotics for the treatment of community-onset acute pyelonephritis due to extended-spectrum I^-lactamase-producing Escherichia coli. (24928854)
2014
2
Xanthogranulomatous pyelonephritis: the case of a perplexing kidney. (25240002)
2014
3
Emphysematous pyelonephritis and cystitis in a renal transplant recipient. (25320257)
2014
4
Are serum procalcitonin and interleukin-1 beta suitable markers for diagnosis of acute pyelonephritis in children? (24874931)
2014
5
Emphysematous Pyelonephritis-a Rare Surgical Emergency Presenting to the Physician: A Case Report and Literature Review. (24426588)
2013
6
Urinary concentration of cytokines in children with acute pyelonephritis. (23389820)
2013
7
Mouse model for pyelonephritis. (23564687)
2013
8
The effects of anemia on pregnancy outcome in patients with pyelonephritis. (24369448)
2013
9
Pyelonephritis in pregnancy. How adequate is empirical treatment? (23546459)
2013
10
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. (23052650)
2013
11
Genotypic Analysis of E. coli Strains Isolated from Patients with Cystitis and Pyelonephritis. (22997556)
2012
12
The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture. (21507269)
2011
13
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
14
Five patients with emphysematous pyelonephritis. (21525582)
2011
15
Emphysematous pyelonephritis and pneumo-vena cava. (21293779)
2010
16
Pharmacotherapy of lower urinary tract infections and pyelonephritis in children. (19663608)
2009
17
A rare association of emphysematous pyelonephritis with unrecognized diabetes and polycystic kidney. (20352007)
2009
18
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. (18828054)
2008
19
A case of portal venous gas after extracorporeal shockwave lithotripsy and obstructive pyelonephritis. (18342210)
2008
20
Antibiotics for acute pyelonephritis in children. (17943796)
2007
21
Emphysematous pyelonephritis in a diabetic patient with pelvic-ureteric stone. (18705456)
2007
22
Some current aspects of diagnosis of calculous pyelonephritis]. (17471991)
2007
23
Renal parenchymal malacoplakia: a different stage of xanthogranulomatous pyelonephritis? (17618870)
2007
24
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
25
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
26
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
27
Successful medical treatment of emphysematous pyelonephritis. (17914710)
2004
28
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
29
Xanthogranulomatous pyelonephritis: urinary and fine needle aspiration cytology. (9684612)
1998
30
Focal xanthogranulomatous pyelonephritis in a teenager. (9717648)
1998
31
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
32
Xanthogranulomatous pyelonephritis in pediatric patients. (7752369)
1995
33
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
34
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
35
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
36
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
37
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986
38
Acute pyelonephritis in pregnancy. (3791931)
1986
39
Xanthogranulomatous pyelonephritis in children. (3968740)
1985
40
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
41
Xanthogranulomatous pyelonephritis with bilharzial ureteric obstruction. (6653472)
1983
42
Peripartum hepatic dysfunction and xanthogranulomatous pyelonephritis. (4576472)
1973
43
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
44
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
45
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
46
XANTHOGRANULOMATOUS PYELONEPHRITIS. (14134284)
1963
47
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
48
CLINICAL pathologic conference: acute and subacute glomerulonephritis with acute pyelonephritis. (13061782)
1953
49
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
50
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950

Variations for Pyelonephritis

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Expression for genes affiliated with Pyelonephritis

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Expression patterns in normal tissues for genes affiliated with Pyelonephritis

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Pathways for genes affiliated with Pyelonephritis

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Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway37
9.2CRP, ALB
28.8CRP, ALB, UMOD

Compounds for genes affiliated with Pyelonephritis

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Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1amikacin449.8B2M, NAGLU
2tobramycin449.8NAGLU, B2M
3fosfomycin449.8NAGLU, B2M
4calcium oxalate449.8UMOD, NAGLU
5aluminium44 1110.7B2M, NAGLU
6mesna449.7B2M, NAGLU
799mtc-dmsa449.5B2M, NAGLU, CRP
8polyether sulfone449.4ALB, B2M
9neopterin449.4NAGLU, B2M, CRP
10fluoride449.3CALCA, B2M, NAGLU
11aopp449.3CRP, ALB
1251-cr-edta449.3B2M, ALB
13pamidronate44 50 1111.3CALCA, CRP, B2M
14pmma449.3CRP, CALCA, B2M
15perindopril44 50 1111.3NAGLU, CRP, ALB
16nitroglycerin44 1110.2B2M, CALCA, CRP
17isoflurane50 44 1111.2NAGLU, ALB, CALCA
18furosemide44 61 28 50 24 1114.2ALB, CALCA, NAGLU
19icodextrin44 1110.1B2M, ALB
20losartan44 50 28 1112.1CRP, ALB, NAGLU
21iopentol449.1ALB, NAGLU, B2M
22p-aminohippuric acid449.1ALB, NAGLU, B2M
23inulin449.1B2M, NAGLU, ALB
24iohexol449.1ALB, B2M, NAGLU
25fosinopril44 1110.1ALB, CRP
26sevoflurane50 44 1111.1B2M, ALB, NAGLU
27calcium carbonate449.0CALCA, B2M
28gamma globulin449.0ALB, CRP, B2M
29pentosidine449.0B2M, ALB, CRP
30dmsa449.0CRP, NAGLU, B2M, CALCA
31polysulfone449.0CRP, B2M, ALB
32vitamin b12448.9ALB, B2M, CRP
33citrate448.9ALB, CRP, UMOD, NAGLU
34captopril44 61 50 28 1112.9B2M, CALCA, ALB
35homocysteine44 249.9NAGLU, ALB, CRP
36urea44 24 1110.7ALB, NAGLU, B2M, UMOD
37mannitol44 119.6ALB, CRP, NAGLU, B2M
38vitamin a44 24 1110.6NAGLU, ALB, CRP, B2M
39phosphorus448.6ALB, CALCA, NAGLU, B2M
40vitamin d448.5NAGLU, ALB, CALCA, B2M
4125-hydroxyvitamin d448.5CRP, ALB, B2M, CALCA
42sodium44 249.5ALB, NAGLU, B2M, UMOD
43iron44 249.5NAGLU, CRP, ALB, B2M
44uric acid44 249.3NAGLU, B2M, ALB, UMOD, CRP
45aspartate448.3CRP, ALB, NAGLU, B2M
46cysteine448.2NAGLU, CXCR1, ALB, UMOD, B2M
47glucose448.2CRP, ALB, UMOD, B2M, NAGLU
48lactate448.1CRP, ALB, CALCA, NAGLU, B2M
49creatinine447.8ALB, CALCA, UMOD, NAGLU, B2M, CRP
50calcium44 50 24 1110.3ALB, CALCA, UMOD, CXCR1, CRP, NAGLU

GO Terms for genes affiliated with Pyelonephritis

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Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.3ALB, UMOD, NAGLU, B2M
2extracellular regionGO:0055767.8CRP, B2M, CALCA, ALB
3extracellular spaceGO:0056157.1UMOD, B2M, CPN1, CRP, ALB, CALCA

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor internalizationGO:0316239.4CALCA, CXCR1
2response to organic substanceGO:0100339.3ALB, UMOD
3inflammatory responseGO:0069549.1CRP, CALCA, CXCR1
4retina homeostasisGO:0018958.7ALB, B2M

Products for genes affiliated with Pyelonephritis

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Sources for Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet