Pyelonephritis malady

Wikipedia: Pyelonephritis (from Greek πήληξ – pyelum, meaning \"renal pelvis\", νεφρός – nephros,...⁴⁴ more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos (disorder), is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Bacterial infections in CF airways and PGC1Alpha Pathway. The drugs cefepime and levofloxacin and the compounds ivig and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and monocytes, and related mouse phenotypes are hematopoietic system and tumorigenesis.

Aliases & Descriptions:

pyelonephritis 6 8 32 43 unspecified pyelonephritis nos (disorder) 6 pyelonephritis unspecified (disorder) 6

pyelonephritis, unspecified 6 pyelonephritis (disorder) 6 pyelonephritis nos 6

Diseases related to pyelonephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 832)

id	Related Disease	Score	Top Affiliating Genes
1	acute pyelonephritis	33.1	NAGLU, NAMPT, LGALS7, LEPREL1, UGT1A1, MMP9
2	chronic pyelonephritis	32.7	NAGLU, LPXN, UMOD, B2M, CD79A, ALB
3	xanthogranulomatous pyelonephritis	31.6	SCG5, MUC1, CCL2, SRMS, EGF, PRCC
4	hydronephrosis	27.5	NAGLU, B2M, IL6, IL8, AQP2, AMBP
5	chronic kidney failure	26.4	B2M, CD79A, INS, ALB, CALCA, TF
6	aldosteronism	25.7	NAGLU, NAMPT, UGT1A1, B2M, MMP9, INS
7	septic shock	25.5	LACTB, XDH, MIF, IL1A, IL1R1, IL6
8	glomerulonephritis	24.9	NAGLU, UMOD, XDH, B2M, CD79A, CD40LG
9	diabetes mellitus	21.3	NAGLU, NAMPT, LPXN, UMOD, UGT1A1, XDH
10	pneumonia	19.9	NAGLU, LGALS7, LEPREL1, MUC1, MUC7, LACTB
11	prostatitis	17.3	SERPINA2, NAGLU, NAMPT, LPXN, SCG5, CHRM3
12	primary hyperoxaluria	13.9	NAGLU, B2M, AMBP, ALB
13	acute kidney tubular necrosis	13.9	B2M, AMBP, ALB
14	urinary tract obstruction	13.8	NAGLU, UMOD, B2M, AMBP, KLK3
15	twin-to-twin transfusion syndrome	13.8	B2M, AMBP, ALB
16	twin twin transfusion syndrome	13.8	B2M, AMBP, ALB
17	hypophosphatemia	13.8	B2M, AMBP, ALB, CALCA, CRP
18	interstitial nephritis	13.8	B2M, ALB, CRP, ACE
19	urinary system disease	13.8	NAGLU, UMOD, LACTB, B2M, KLK3
20	t-lymphocytopenia	13.8	IL7, ALB, CRP
21	malignant histiocytosis	13.8	IL1A, IL1R1, TNFRSF8, CRP
22	adult-onset still's disease	13.8	IL1R1, IL6, CRP
23	viral pneumonia	13.8	IL6, GPT, ALB, CRP
24	tick-borne encephalitis	13.7	B2M, CCL2, GPT, ALB, CRP
25	muckle-wells syndrome	13.7	IL1R1, IL8, CRP
26	drug-induced hepatitis	13.7	UGT1A1, GPT, ALB, CP
27	temporal arteritis	13.7	CCL2, CALCA, CRP
28	aspiration pneumonia	13.7	LACTB, CRP, ACE
29	extrapulmonary tuberculosis	13.7	IL1A, MBL2, CCL2, CRP
30	bacteremia, protection against	13.7	LACTB, MBL2, CRP
31	legionnaires' disease	13.7	ALB, CRP, TLR4, CXCL10
32	rheumatoid arthritis	13.7	IL1R1, MBL2, CRP
33	viral meningitis	13.7	B2M, IL6, IL8, CRP, CXCL10
34	acute liver failure	13.7	GPT, ALB, CP
35	idiopathic myopathy	13.7	IL1A, IL1R1, CCL2
36	funisitis	13.7	IL6, IL8, CRP
37	periodic fever	13.7	MIF, IL1R1, TNF, CRP
38	relapsing polychondritis	13.7	CD79A, IL7, IL8, CCL2, CRP
39	cold agglutinin disease	13.7	IL6, TNF, CRP
40	spondylarthropathy	13.7	B2M, TNF, CRP, TLR4
41	choledocholithiasis	13.7	UGT1A1, GPT, ALB
42	rapidly progressive glomerulonephritis	13.7	CCL2, TNF, CRP
43	opportunistic bacterial infectious disease	13.7	LACTB, B2M, IL7, TNF
44	galactosemia	13.7	AQP2, GPT, ALB, CP
45	vulvar vestibulitis syndrome	13.7	IL1R1, MBL2, TNF
46	hepatorenal syndrome	13.7	NAGLU, AQP2, ALB, TNF, ACE
47	euthyroid sick syndrome	13.7	IL6, GPT, ALB, POMC
48	chronic rapidly progressive glomerulonephritis	13.7	NAGLU, B2M, CD79A, AMBP, ALB, ACE
49	paratyphoid fever	13.7	IL1A, IL1R1, TNF, CRP
50	amyloid tumor	13.7	B2M, CALCA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cefepime, cefepime hydrochloride, ertapenem, gatifloxacin, levofloxacin, moxifloxacin, moxifloxacin hcl

MalaCards organs/tissues related to pyelonephritis:

²²

MGI Mouse Phenotypes related to pyelonephritis:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.1	EPO, CSF3, ALAS2, MIF
2	tumorigenesis	MP:0002006	9.0	POMC, TIMP1, TLR4, ACE, TNF, CCL2
3	renal/urinary system phenotype	MP:0005367	9.0	ADM, GLI3, AQP2, INS, CD55, CHRM3
4	immune system phenotype	MP:0005387	8.9	TNFRSF8, TLR4, CXCL10, POMC, CPN1, ADM
5	reproductive system phenotype	MP:0005389	8.9	GALP, TIMP1, TLR4, TNF, GLI3, AMBP
6	endocrine/exocrine gland phenotype	MP:0005379	8.6	GALP, GLI3, CD40LG, XDH, CHRM3, SCG5
7	liver/biliary system phenotype	MP:0005370	8.5	EPO, ADM, TLR4, IL6, IL1R1, INS
8	adipose tissue phenotype	MP:0005375	8.1	POMC, TLR4, ACE, TNF, CCL2, IL6
9	vision/eye phenotype	MP:0005391	7.9	TLR4, EGF, TNF, GLI3, CCL2, IL6
10	integument phenotype	MP:0010771	7.8	POMC, CSF3, TLR4, EGF, GLI3, CALCA
11	behavior/neurological phenotype	MP:0005386	7.5	CALCA, ACE, TLR4, POMC, CP, ADM
12	mortality/aging	MP:0010768	7.5	GLI3, ACE, HCCS, TLR4, TF, PROZ
13	growth/size phenotype	MP:0005378	7.2	AQP2, GLI3, EGF, ACE, HCCS, TLR4
14	cellular phenotype	MP:0005384	6.6	GLI3, TNF, TNFRSF8, ACE, HCCS, TLR4
15	cardiovascular system phenotype	MP:0005385	6.6	TLR4, HCCS, ACE, CRP, TIMP1, PROZ
16	homeostasis/metabolism phenotype	MP:0005376	5.0	GALP, ALAS2, ALB, CALCA, GLI3, CRP

Articles related to pyelonephritis:

(show top 50)    (show all 72)

id	Title	Authors	Year	Affiliating Genes
1	The IL-6 -174G/C polymorphism and renal scarring in c hildren with first acute pyelonephritis. (20632037)	SpasojeviA8-Dimitrijeva B.... KostiA8 M.	2010	IL6
2	Acute pyelonephritis during pregnancy changes the bal ance of angiogenic and anti-angiogenic factors in maternal plasma. (20213923)	Chaiworapongsa T.... Hassan S.S.	2010	IL7
3	Urine macrophage migration inhibitory factor (MIF) in children with urinary tract infection: a possible predictor of acute pyelonephritis. (18800229)	Otukesh H.... Mahdavi S.	2009	MIF
4	Abnormalities in aminotransferase levels during acute pyelonephritis. (19393479)	Campos J.... Gonzalez-Quintela A.	2009	GPT, GOT1
5	Diagnostic potential of urinary tumor necrosis factor -alpha in children with acute pyelonephritis. (19395784)	Mohkam M.... Abdollah Gorgi F.	2009	TNF
6	Clinical implication of serum C-reactive protein in patients with uncomplicated acute pyelonephritis as marker of prolonged hospitalization and recurrence. (18930516)	Yang W.J.... Kim H.S.	2009	CRP
7	Effect of bacteriophage on the serum level of iron and copper in pregnant women with pyelonephritis (18720732)	Terekhina N.A.... Makarova E.L.	2008	TF
8	Urinary N-acetyl-beta-D-glucosaminidase as a diagnostic marker of acute pyelonephritis in children. (19367005)	Mohkam M.... Sharifian M.	2008	NAGLU
9	Secondary polycythaemia associated with high plasma erythropoietin concentrations in a dog with a necrotising pyelonephritis. (18482331)	Kessler M.	2008	EPO
10	Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)	Smithson A.... Lozano F.	2007	MBL2
11	Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis. (17853184)	Kusanovic J.P.... Hassan S.S.	2007	TNFRSF8
12	Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. (17357062)	Lundstedt A.C.... Svanborg C.	2007	CXCR1
13	A genetic basis of susceptibility to acute pyelonephritis. (17786197)	Lundstedt A.C.... Svanborg C.	2007	CXCR1
14	Rare coexistence of keratinizing squamous metaplasia with xanthogranulomatous pyelonephritis. Report of a case with the role of immunocytochemistry in the differential diagnosis. (17328505)	Dhingra K.K.... Jain S.	2007	MUC1
15	Xanthogranulomatous pyelonephritis is associated with higher tissue expression of monocyte chemotactic protein-1. (17968796)	Bartoli F.... Magaldi S.	2007	EGF, CCL2
16	Clinical differentiation of acute pyelonephritis from lower urinary tract infection in children. (18087632)	Huang D.T.... Lin C.C.	2007	CRP
17	The clinical impact of bacteremia in complicated acute pyelonephritis. (17031242)	Hsu C.Y.... Chung H.M.	2006	ALB
18	Urinary aquaporin-2 in children with acute pyelonephritis. (16382324)	Rodionova E.A.... Zelenina M.	2006	AQP2
19	Combined rehabilitation of patients with chronic pyelonephritis (16862887)	Rudichenko E.V.... Antoniuk M.V.	2006	LPXN
20	Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis (16308433)	Dzhodzhua G.N.... Kochiashvili D.K.	2005	IL6, IL8
21	Correlation of renal ultrasonographic findings with i nflammatory volume from dimercaptosuccinic acid renal scans in children with ac ute pyelonephritis. (15592072)	Wang Y.T.... Chiou Y.Y.	2005	CRP
22	Plasma and urinary adrenomedullin levels in children with acute pyelonephritis. (16221100)	Kalman S.... Soylemezoglu O.	2005	ADM
23	Tc 99M DMSA scintigraphy in children with a first ep isode of acute pyelonephritis: correlation with laboratory tests, echography an d the presence of vesico-ureteral reflux (15379054)	Donoso G.... JimAcnez C.	2004	CRP
24	Application of serum PSA to identify acute bacterial prostatitis in patients with fever of unknown origin or symptoms of acute pyelonephritis. (15264238)	Hara N.... Kawaguchi M.	2004	KLK3
25	Long-term follow-up of women hospitalized for acute pyelonephritis. (14523764)	Raz R.... Kunin C.	2003	ALB
26	Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice. (12562381)	Hertting O.... Brauner A.	2003	CXCL2
27	ACE gene polymorphism and renal scar in children with acute pyelonephritis. (12172760)	Cho S.J.... Lee S.J.	2002	ACE
28	Acute pyelonephritis: analysis of 52 cases. (12380905)	Rollino C.... Quarello F.	2002	CRP
29	Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults (11484399)	Martinot M.... Christmann D.	2001	CRP
30	Cytokine profiles of pediatric patients treated with antibiotics for pyelonephritis: potential therapeutic impact. (11687440)	Kassir K.... Arrieta A.	2001	IL6
31	Polymorphonuclear elastase as a diagnostic marker of acute pyelonephritis in children. (10654988)	Fretzayas A.... Stavrinadis C.	2000	CRP
32	A case of emphysematous pyelonephritis improved with conservative therapy--indication for conservative therapy (10876758)	Kondo T.... Toma H.	2000	CRP
33	Role of IL-8 and defensins in pathogenesis of chronic glomerulonephritis and pyelonephritis (10515041)	Rebenok A.Z.h.... Chizh A.S.	1999	IL8
34	Procalcitonin is a marker of severity of renal lesion s in pyelonephritis. (9832579)	Benador N.... Girardin E.	1998	CRP
35	Microproteinuria and enzymuria in fever and pyelonephritis in childhood. A prospective study of 180 children (9123685)	ZAPller G.... Ringert R.H.	1997	AMBP
36	A study of interleukin-8 and defensins in urine and plasma of patients with pyelonephritis and glomerulonephritis. (9430851)	Tikhonov I.... Chyzh A.	1997	IL8
37	Tumour necrosis factor soluble receptors I and II and interleukin-1 receptor antagonist in acute pyelonephritis in relation to bacterial virulence-associated traits and renal function. (8941580)	Jacobson S.H.... Brauner A.	1996	IL1R1
38	Interleukin-1 alpha and interleukin-1 receptor antagonist in the urine of children with acute pyelonephritis and relation to renal scarring. (8640042)	Tullus K.... Brauner A.	1996	IL1R1, IL1A
39	Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis (7817590)	Starzyk J.... Bartelik S.	1994	ALB
40	Interleukin-6 and interleukin-8 in the urine of children with acute pyelonephritis. (7917851)	Tullus K.... Brauner A.	1994	IL6, IL8
41	The plasma interleukin-6 and stress hormone responses to acute pyelonephritis. (7930378)	Donald R.A.... Smith A.H.	1994	IL6, POMC
42	Erythropoietin in pregnancies complicated by pyelonephritis. (8041541)	Cavenee M.R.... Cunningham F.G.	1994	EPO
43	Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. (7696107)	LinnAc T.... Tullus K.	1994	NAGLU
44	The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure (7532880)	NeA-mark A.I.... Iakovets I.a.V.	1994	CD79A
45	The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis (7940364)	Kulaeva N.N.... Shulutko B.I.	1994	HLA-A
46	Renal scarring after acute pyelonephritis. (8129430)	Jakobsson B.... Svensson L.	1994	CRP
47	The treatment of acute suppurative pyelonephritis in diabetes mellitus patients (8296230)	Dovlatian A.A.	1993	INS
48	Urinary N-acetyl-beta-glucosaminidase in normal Chinese children and children with pyelonephritis. (2063674)	Tsau Y.K.... Sheu J.N.	1991	NAGLU
49	Etiology and pathophysiology of pyelonephritis. (1670905)	Roberts J.A.	1991	XDH
50	Study of the effect of combination therapy of human granulocyte-colony stimulating factor (G-CSF) and amikacin on experimental pyelonephritis induced by Pseudomonas aeruginosa in neutropenic mice (1698897)	Tanaka N.... Yokoo A.	1990	CSF3

Genes related to pyelonephritis according to GeneCards:

(show top 50)    (show all 67)

id	Symbol	Description	Score	GeneCards Section Context
1	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
2	UMOD	uromodulin	11.0
3	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
4	CRP	C-reactive protein, pentraxin-related	11.0	Publications
5	B2M	beta-2-microglobulin	11.0
6	ALB	albumin	11.0	Publications
7	HCCS	holocytochrome c synthase	11.0
8	LGALS7	lectin, galactoside-binding, soluble, 7	11.0
9	GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	11.0	Publications
10	CPN1	carboxypeptidase N, polypeptide 1	11.0
11	FBP1	fructose-1,6-bisphosphatase 1	11.0	Publications
12	LPXN	leupaxin	11.0	Publications
13	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
14	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
15	ADM	adrenomedullin	11.0	Publications
16	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
17	AQP2	aquaporin 2 (collecting duct)	11.0	Publications
18	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
19	IL7	interleukin 7	11.0	Publications
20	LEPREL1	leprecan-like 1	11.0
21	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
22	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
23	CP	ceruloplasmin (ferroxidase)	11.0	Publications
24	IL1R1	interleukin 1 receptor, type I	11.0	Publications
25	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
26	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
27	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
28	IL8	interleukin 8	11.0	Publications
29	KLK3	kallikrein-related peptidase 3	11.0	Publications
30	LACTB	lactamase, beta	11.0
31	IL1A	interleukin 1, alpha	11.0	Publications
32	POMC	proopiomelanocortin	11.0	Publications
33	MUC1	mucin 1, cell surface associated	11.0	Publications
34	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
35	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
36	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
37	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
38	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
39	TLR4	toll-like receptor 4	11.0
40	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
41	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
42	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
43	EGF	epidermal growth factor	11.0	Publications
44	TNF	tumor necrosis factor	11.0	Publications
45	IGKV1-37	immunoglobulin kappa variable 1-37 (non-functional)	11.0
46	IGKV1-33	immunoglobulin kappa variable 1-33	11.0
47	SRMS	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	11.0
48	PROZ	protein Z, vitamin K-dependent plasma glycoprotein	11.0	Publications
49	GALP	galanin-like peptide	11.0
50	SERPINA2	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2	11.0

Pathways related to pyelonephritis according to GeneDecks:

(show top 50)    (show all 61)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	IL1R1, MUC1
2	PGC1Alpha Pathway36	10.5	IL8, IL7, IL1R1, IL1A
3	Graft-versus-host disease20	10.4	HLA-A, IL1A
4	Cell adhesion_ECM remodeling41	10.3	CXCR1, TIMP1, KLK3, IL8, MMP9
5	Cell adhesion ECM remodeling10	10.3	CXCR1, TIMP1, KLK3, IL8, MMP9
6	Akt Signaling36	10.3	CXCL10, TNFRSF8, TNF, CCL2, IL7, IL6
7	Regulation of eIF4 and p70S6K36	10.3	EGF, IL7, IL6, IL1A
8	Immune response_MIF-mediated glucocorticoid regulation41	10.3	TNF, IL8, IL6, MIF
9	Immune response_MIF in innate immunity response41	10.3	TLR4, TNF, IL8, IL6, MIF
10	Immune response MIF in innate immunity response10	10.3	TLR4, TNF, IL8, IL6, MIF
11	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.3	CXCL10, IL6
12	Immune response MIF-mediated glucocorticoid regulation10	10.3	TNF, IL8, IL6, MIF
13	Immune response IL-1 signaling pathway10	10.2	CP, TNF, IL8, IL6, IL1R1, IL1A
14	Immune response_IL-1 signaling pathway41	10.2	CP, TNF, IL8, IL6, IL1R1, IL1A
15	Cytokine Network36	10.2	TNF, IL8, IL6, IL1A
16	Rheumatoid arthritis20	10.1	TLR4, TNF, CCL2, IL8, IL6, IL1A
17	IL-10 Pathway36	10.1	IL1A, IL6, TNF, TLR4
18	NOD-like receptor signaling pathway20	10.1	CXCL2, TNF, CCL2, IL8, IL6
19	Pertussis20	10.1	TLR4, TNF, IL8, IL6, IL1A
20	Chagas disease (American trypanosomiasis)20	10.0	TLR4, ACE, TNF, CCL2, IL8, IL6
21	Tec Kinases Signaling36	10.0	TIMP1, TLR4, EGF, TNFRSF8, CCL2, IL8
22	Molecular Mechanisms of Cancer36	10.0	CXCL2, TIMP1, EGF, TNFRSF8, IL7, IL6
23	Influenza A20	10.0	CXCL10, TLR4, TNF, CCL2, IL8, IL6
24	Selected targets of HNF110	10.0	CRP, ALB, INS, UMOD
25	TGF-Beta Pathway36	10.0	TIMP1, EGF, CCL2, IL8, IL7, IL6
26	Porphyrin and chlorophyll metabolism20	9.9	CP, HCCS, ALAS2, UGT1A1
27	NF-KappaB (p50-p65) Pathway36	9.9	TIMP1, TLR4, EGF, TNF, IL6, IL1R1
28	NF-KappaB Family Pathway36	9.8	TIMP1, TLR4, EGF, TNF, IL6, IL1R1
29	MAPK Family Pathway36	9.8	TIMP1, EGF, TNF, CCL2, IL8, IL7
30	RAR-Gamma-RXR-Alpha Degradation36	9.8	CSF3, CXCL2, IL7
31	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.7	CALCA, IL6, IL1A, TNF
32	SOCS Pathway36	9.7	EGF, CCL2, IL8, IL7, IL6, IL1A
33	Type I diabetes mellitus20	9.6	TNF, HLA-A, IL1A, INS
34	Endothelin-1 Signaling Pathway36	9.4	CSF3, CXCL2, CXCL10, IL7, IL6, IL1A
35	JAK-STAT Pathway36	9.4	EPO, TIMP1, EGF, CCL2, IL8, IL7
36	Cytokine production by Th17 cells in CF41	9.3	CSF3, TLR4, IL8, IL6
37	Rho Family GTPases36	9.3	CSF3, CXCL2, CXCL10, TIMP1, CCL2, IL8
38	Malaria20	9.1	CSF3, TLR4, TNF, CCL2, IL8, IL6
39	ERK Signaling36	9.1	CSF3, CXCL2, CXCL10, TIMP1, EGF, IL7
40	all-trans-Retinoic Acid Signaling in Brain36	9.1	CSF3, CXCL2, CXCL10, TNF, CCL2, IL8
41	PEDF Induced Signaling36	9.1	CSF3, CXCL2, CXCL10, TNF, CCL2, IL8
42	IL-6 Pathway36	9.0	TIMP1, CXCL10, CXCL2, CSF3, TNF, CCL2
43	STAT3 Pathway36	9.0	TNFRSF8, CXCL10, CXCL2, CSF3, TNF, CCL2
44	PAK Pathway36	9.0	CSF3, CXCL2, CXCL10, TIMP1, TNF, CCL2
45	MIF Mediated Glucocorticoid Regulation36	8.9	CSF3, CXCL2, CXCL10, TLR4, TNF, CCL2
46	MIF Regulation of Innate Immune Cells36	8.9	TLR4, CXCL10, CXCL2, CSF3, TNF, CCL2
47	Hematopoietic cell lineage20	8.9	EPO, CSF3, TNF, IL7, IL6, IL1R1
48	Antioxidant Action of Vitamin-C36	8.7	EGF, TIMP1, CXCL10, CXCL2, CSF3, TNFRSF8
49	p38 Signaling36	8.7	EGF, TIMP1, CXCL10, CXCL2, CSF3, TNFRSF8
50	Cytokine-cytokine receptor interaction20	7.9	CD40LG, EPO, CSF3, CXCR1, CXCL2, CXCL10

Compounds related to pyelonephritis according to GeneDecks:

(show top 50)    (show all 336)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.7	CRP
2	hyaluronic acid32 18	11.3	MUC1, B2M, GPT, KLK3, CXCL2
3	glucose32	10.3	SERPINA2, UMOD, MIF, AMBP, GALP
4	n acetylcysteine32	9.9	TLR4, TIMP1, CXCL2, GPT, IL1R1, NAGLU
5	groalpha32	9.7	TNF, IL1A, CCL2, CXCL2, CXCL10
6	il 1032	9.7	TLR4, TNF, CCL2, IL8, CXCL10, IL7
7	neopterin32	9.4	GPT, TNF, CRP, CXCL10, MBL2, IL8
8	uric acid32 18	10.3	UMOD, ALB, AMBP, GPT, IL1R1, INS
9	aspartate32	9.3	NAGLU, CHRM3, B2M, CD40LG, CD55, MMP9
10	endotoxin32	9.2	CSF3, ADM, CXCR1, CXCL2, MIF, IL1R1
11	sialic acid32	9.2	CD55, NAGLU, CD79A, MBL2, AMBP, EPO
12	pge232	9.1	IL1A, IL1R1, AQP2, EGF, TLR4, DPEP1
13	indomethacin32 9 9	11.0	IL1A, IL1R1, IL6, ALB, TNF, EGF
14	epinephrine32 9 18 9	12.0	IL1A, AQP2, KLK3, CP, POMC, TF
15	heparin32 9 18 9	11.9	UMOD, SCG5, CD79A, EGF, CHRM3, CP
16	genistein32 9 18 9	11.9	EGF, TLR4, CXCL10, CXCR1, MIF, UGT1A1
17	vitamin b1232	8.8	EPO, TIMP1, B2M, CD79A, CD40LG, CCL2
18	ccl332	8.8	MMP9, IL1A, IL1R1, IL6, IL8, CCL2
19	nitric oxide32 9 18 9	11.8	DPEP1, CXCL10, CXCL2, ADM, TIMP1, TLR4
20	actinomycin d32	8.7	MUC1, ADM, CXCR1, TLR4, EGF, TNF
21	8-isoprostane32	8.6	IL8, CCL2, XDH, TNF, CRP, MMP9
22	vitamin d32	8.5	NAGLU, SCG5, B2M, CD79A, IL1A, IL1R1
23	estrogen32	8.5	EGF, KLK3, UGT1A1, INS, MIF, TIMP1
24	thyroxine32 18	9.4	CALCA, B2M, POMC, CD40LG, INS, MBL2
25	testosterone32 9 18 9	11.4	SERPINA2, SCG5, UGT1A1, MUC1, B2M, EPO
26	rantes32	8.3	IL1A, IL1R1, IL6, IL7, MBL2, CCL2
27	folate32	8.3	CD79A, CP, CD40LG, FBP1, ALB, CRP
28	paraffin32	8.2	SCG5, TF, POMC, ADM, MUC1, B2M
29	prednisolone32 9 9	10.2	CRP, CD79A, TNF, TF, CSF3, POMC
30	cyclosporin a32 42	9.2	NAGLU, CHRM3, B2M, CD55, MMP9, IL1A
31	histamine32 18	9.2	ADM, TF, SCG5, CD79A, CD55, IL6
32	cysteine32	8.0	AQP2, AMBP, MUC7, MUC1, CHRM3, UMOD
33	cycloheximide32	7.8	B2M, IL6, IL7, IL8, CCL2, ALAS2
34	thymidine32 18	8.8	CSF3, UGT1A1, MUC1, B2M, MIF, IL1A
35	hydrocortisone32 9 9	9.7	MUC1, MIF, INS, IL1A, IL1R1, IL6
36	fibrinogen32	7.7	TLR4, TF, CXCL2, CP, CRP, ALB
37	norepinephrine32 9 18 9	10.7	CHRM3, CD79A, CD40LG, MMP9, MIF, INS
38	methotrexate32 34 42 9 9	11.7	IL6, EPO, CSF3, NAGLU, MUC1, CD79A
39	iron32 18	8.6	B2M, XDH, ALB, LEPREL1, NAGLU, SERPINA2
40	ribavirin32 34 9 9	10.6	CXCL10, TF, TIMP1, GPT, MBL2, MMP9
41	cholesterol32 9 18 9	10.6	IL1R1, INS, CD55, B2M, MUC1, UGT1A1
42	retinoic acid32 42 18	9.5	IL1R1, MIF, MUC1, MUC7, B2M, CD40LG
43	creatinine32	7.4	MBL2, CCL2, AMBP, CRP, ACE, DPEP1
44	cisplatin32 34 9 9	10.3	IL1R1, UGT1A1, MUC1, EPO, XDH, CSF3
45	vegf32	6.8	EPO, ADM, CP, POMC, CSF3, CXCR1
46	alanine32	6.8	NAGLU, CD40LG, CD55, MMP9, MIF, SCG5
47	lipid32	6.6	TNF, ALB, AMBP, GPT, CCL2, MBL2
48	serine32	6.6	KLK3, EGF, TLR4, TIMP1, POMC, CP
49	lactate32	6.5	IL8, GPT, AMBP, ALB, CALCA, TNF
50	dexamethasone32 42 34 9 9	10.2	SCG5, KLK3, EGF, TLR4, TIMP1, CXCL10

Cellular components related to pyelonephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	9.4	TLR4, ACE, TNF, CD40LG, CD79A, B2M
2	extracellular space	GO:005615	5.8	EPO, MBL2, IL8, IL7, IL6, IL1A
3	extracellular region	GO:005576	4.8	GALP, EPO, ADM, CP, IL7, IL6

Biological processes related to pyelonephritis according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor internalization	GO:031623	10.5	ADM, CXCR1, CALCA, IL8
2	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.4	TLR4, CCL2, NAMPT
3	negative regulation of lipid storage	GO:010888	10.4	IL6, TNF, CRP
4	response to molecule of bacterial origin	GO:002237	10.4	CXCL2, IL8, B2M
5	monocyte chemotaxis	GO:002548	10.3	IL6, CCL2, CALCA
6	response to glucocorticoid stimulus	GO:051384	10.3	ADM, CPN1, TNF, GOT1, CCL2, IL6
7	positive regulation of interleukin-6 production	GO:032755	10.2	TLR4, TNF, IL6, IL1A
8	humoral immune response	GO:006959	10.2	IL6, IL7, CCL2, TNF
9	positive regulation of B cell proliferation	GO:030890	10.1	TLR4, IL7, MIF, CD40LG
10	positive regulation of cytokine secretion	GO:050715	9.9	TNF, IL1A, INS, MIF
11	acute-phase response	GO:006953	9.9	CRP, MBL2, IL6, INS
12	response to salt stress	GO:009651	9.9	EPO, TNF, AQP2
13	aging	GO:007568	9.9	EPO, ADM, TIMP1, CALCA, CCL2, AQP2
14	positive regulation of mitosis	GO:045840	9.8	EGF, TNF, IL1A, INS
15	response to hypoxia	GO:001666	9.8	ADM, TLR4, CRP, TNF, ALAS2, CCL2
16	embryonic digestive tract development	GO:048566	9.8	TNF, GLI3, IL8
17	positive regulation of chemokine production	GO:032722	9.7	TLR4, TNF, IL6
18	positive regulation of vasodilation	GO:045909	9.7	ADM, CALCA, INS
19	response to lipopolysaccharide	GO:032496	9.7	EPO, ADM, CXCL10, TLR4, AQP2, IL1A
20	cell-cell signaling	GO:007267	9.6	ADM, POMC, CXCL10, CALCA, IL7, INS
21	negative regulation of cell proliferation	GO:008285	9.6	ADM, TNFRSF8, TNF, GLI3, IL8, IL6
22	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.5	TLR4, TNFRSF8, TNF, IL6, INS
23	inflammatory response	GO:006954	9.4	CD40LG, CXCR1, CXCL2, CXCL10, CRP, TNF
24	anti-apoptosis	GO:006916	9.1	TNF, CCL2, IL1A, CD40LG, MUC1, EPO
25	immune response	GO:006955	9.0	CSF3, CXCL2, CXCL10, TLR4, HLA-A, IL8
26	negative regulation of apoptotic process	GO:043066	8.5	EPO, DPEP1, TIMP1, TNF, GLI3, ALB
27	positive regulation of cell proliferation	GO:008284	8.3	EPO, ADM, CSF3, CXCL10, TIMP1, EGF

Molecular functions related to pyelonephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	pyridoxal phosphate binding	GO:030170	10.0	GPT, GOT1, ALAS2, ALB
2	chemokine activity	GO:008009	9.7	CXCL2, CXCL10, CCL2, IL8
3	receptor binding	GO:005102	9.7	ADM, POMC, CXCL10, HLA-A, CALCA, CCL2
4	hormone activity	GO:005179	9.0	GALP, EPO, ADM, POMC, CALCA, INS
5	cytokine activity	GO:005125	8.8	NAMPT, CSF3, TNF, IL7, IL6, IL1A
6	protein binding	GO:005515	4.7	EGF, KLK3, CRP, TNF, HLA-A, GLI3