MCID: PYL005
MIFTS: 54

Pyelonephritis malady

Nephrological diseases category

Summaries for Pyelonephritis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Pyelonephritis /pa??lo?n??fra?t?s/ (from Greek ????? ? pyelum, meaning \"renal pelvis\", ?????? ?... more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selenium Pathway and Selected targets of HNF1. The compounds amikacin and tobramycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related mouse phenotypes are immune system and renal/urinary system.

Aliases & Classifications for Pyelonephritis

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

pyelonephritis 9 11 46 63
unspecified pyelonephritis nos 9
pyelonephritis, unspecified 9
pyelonephritis unspecified 9
pyelonephritis nos 9


External Ids:

Disease Ontology9 DOID:11400
MeSH36 D011704
NCIt41 C34965
ICD9CM28 590.80

Related Diseases for Pyelonephritis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Pyelonephritis family:

Acute Pyelonephritis Chronic Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis31.8NAGLU, CXCR1, CRP
2chronic pyelonephritis31.6B2M, NAGLU, UMOD
3cystitis30.9UMOD, NAGLU
4vesicoureteral reflux30.8UMOD, NAGLU
5hypertension30.8CRP, ALB, CALCA
6bacteriuria30.7CRP, UMOD
7nephritis30.5ALB, B2M
8glomerulonephritis30.5B2M, NAGLU, UMOD, ALB
9amyloidosis30.4B2M, ALB, CRP
10sepsis30.3CRP, ALB, CALCA, CXCR1
11amyloidosis, secondary30.3CRP, B2M
12nephrotic syndrome30.2ALB, NAGLU, B2M
13tuberculosis30.2CXCR1, ALB, CRP
14diabetes mellitus30.2B2M, NAGLU, UMOD, CALCA, ALB, CRP
15proteinuria30.1B2M, NAGLU, UMOD, ALB, CRP
16rheumatoid arthritis29.9CRP, CXCR1, NAGLU, B2M
17arthritis29.9B2M, CXCR1, CALCA, ALB, CRP
18lupus nephritis29.8ALB, NAGLU
19urinary tract obstruction29.8B2M, NAGLU, UMOD
20hyperhomocysteinemia29.8ALB, CRP
21hyperparathyroidism29.8ALB, CALCA
22uremia29.7CRP, ALB, B2M
23hypercalcemia29.7ALB, CALCA, B2M
24pancreatitis29.7CRP, ALB
25acute kidney failure29.7B2M, NAGLU, UMOD, ALB
26myeloma29.7B2M, NAGLU, UMOD, ALB
27chronic kidney failure29.6B2M, NAGLU, UMOD, ALB, CRP
28breast cancer29.6NAGLU, CXCR1, CALCA, ALB
29xanthogranulomatous pyelonephritis11.2
30pyelitis10.4
31hydronephrosis10.4
32renal cell carcinoma10.4
33hepatitis10.3
34bacteremia10.3
35urethritis10.3
36interstitial nephritis10.3
37septic shock10.3
38blindness10.3
39pseudohypoaldosteronism10.2
40lipomatosis10.2
41horseshoe kidney10.2
42perinephritis10.2
43acute cystitis10.2
44malignant hypertension10.2
45prostatitis10.2
46malakoplakia10.2
47pyuria10.1
48nephrolithiasis10.1
49adenocarcinoma10.1
50osteomyelitis10.1

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Symptoms for Pyelonephritis

About this section

Drugs & Therapeutics for Pyelonephritis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Pyelonephritis

Search NIH Clinical Center for Pyelonephritis

Search CenterWatch for Pyelonephritis

Genetic Tests for Pyelonephritis

About this section

Anatomical Context for Pyelonephritis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pyelonephritis:

34
Kidney, Testes, Liver, Prostate, Colon, Cortex, Spinal cord, Bone, Brain, T cells, Monocytes, Whole blood, Lymph node, Ovary, Breast, Thyroid, Lung, Spleen, B cells

Animal Models for Pyelonephritis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pyelonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2CRP, UMOD, NAGLU, CPN1, B2M
2MP:00053678.1ALB, CALCA, UMOD, NAGLU

Publications for Pyelonephritis

About this section
Sources:
53PubMed
See all sources

Articles related to Pyelonephritis:

(show top 50)    (show all 1523)
idTitleAuthorsYear
1
Emphysematous Pyelonephritis-a Rare Surgical Emergency Presenting to the Physician: A Case Report and Literature Review. (24426588)
2013
2
Urinary concentration of cytokines in children with acute pyelonephritis. (23389820)
2013
3
Mouse model for pyelonephritis. (23564687)
2013
4
The effects of anemia on pregnancy outcome in patients with pyelonephritis. (24369448)
2013
5
Pyelonephritis in pregnancy. How adequate is empirical treatment? (23546459)
2013
6
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. (23052650)
2013
7
Treatment of pyelonephritis caused by extended-spectrum I^-lactamase-producing Enterobacteriaceae in children. (23274920)
2013
8
Genotypic Analysis of E. coli Strains Isolated from Patients with Cystitis and Pyelonephritis. (22997556)
2012
9
The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture. (21507269)
2011
10
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
11
Five patients with emphysematous pyelonephritis. (21525582)
2011
12
Emphysematous pyelonephritis and pneumo-vena cava. (21293779)
2010
13
Pharmacotherapy of lower urinary tract infections and pyelonephritis in children. (19663608)
2009
14
A rare association of emphysematous pyelonephritis with unrecognized diabetes and polycystic kidney. (20352007)
2009
15
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. (18828054)
2008
16
A case of portal venous gas after extracorporeal shockwave lithotripsy and obstructive pyelonephritis. (18342210)
2008
17
Antibiotics for acute pyelonephritis in children. (17943796)
2007
18
Emphysematous pyelonephritis in a diabetic patient with pelvic-ureteric stone. (18705456)
2007
19
Some current aspects of diagnosis of calculous pyelonephritis]. (17471991)
2007
20
Renal parenchymal malacoplakia: a different stage of xanthogranulomatous pyelonephritis? (17618870)
2007
21
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
22
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
23
Clarithromycin: immunomodulatory therapy of experimental sepsis and acute pyelonephritis by Escherichia coli. (15764190)
2005
24
Correlational studies of urine interleukin 6, interleukin 8 and nitric oxide in the patients with pyelonephritis and hydronephrosis]. (16308433)
2005
25
Successful medical treatment of emphysematous pyelonephritis. (17914710)
2004
26
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
27
Xanthogranulomatous pyelonephritis: urinary and fine needle aspiration cytology. (9684612)
1998
28
Focal xanthogranulomatous pyelonephritis in a teenager. (9717648)
1998
29
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
30
Xanthogranulomatous pyelonephritis in pediatric patients. (7752369)
1995
31
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
32
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
33
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
34
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
35
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
36
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986
37
Acute pyelonephritis in pregnancy. (3791931)
1986
38
Xanthogranulomatous pyelonephritis in children. (3968740)
1985
39
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
40
Xanthogranulomatous pyelonephritis with bilharzial ureteric obstruction. (6653472)
1983
41
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
42
Peripartum hepatic dysfunction and xanthogranulomatous pyelonephritis. (4576472)
1973
43
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
44
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
45
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
46
XANTHOGRANULOMATOUS PYELONEPHRITIS. (14134284)
1963
47
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
48
CLINICAL pathologic conference: acute and subacute glomerulonephritis with acute pyelonephritis. (13061782)
1953
49
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
50
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950

Variations for Pyelonephritis

About this section

Expression for genes affiliated with Pyelonephritis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for genes affiliated with Pyelonephritis

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore
See all sources

Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway39
9.2CRP, ALB
28.8CRP, ALB, UMOD

Compounds for genes affiliated with Pyelonephritis

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
See all sources

Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1amikacin469.8B2M, NAGLU
2tobramycin469.8NAGLU, B2M
3fosfomycin469.8NAGLU, B2M
4calcium oxalate469.8UMOD, NAGLU
5aluminium46 1210.7B2M, NAGLU
6mesna469.7B2M, NAGLU
799mtc-dmsa469.5B2M, NAGLU, CRP
8polyether sulfone469.4ALB, B2M
9neopterin469.4NAGLU, B2M, CRP
10fluoride469.3CALCA, B2M, NAGLU
11aopp469.3CRP, ALB
1251-cr-edta469.3B2M, ALB
13pamidronate46 52 1211.3CALCA, CRP, B2M
14pmma469.3CRP, CALCA, B2M
15perindopril46 52 1211.3NAGLU, CRP, ALB
16nitroglycerin46 1210.2B2M, CALCA, CRP
17isoflurane52 46 1211.2NAGLU, ALB, CALCA
18furosemide46 62 30 52 25 1214.2ALB, CALCA, NAGLU
19icodextrin46 1210.1B2M, ALB
20losartan46 52 30 1212.1CRP, ALB, NAGLU
21iopentol469.1ALB, NAGLU, B2M
22p-aminohippuric acid469.1ALB, NAGLU, B2M
23inulin469.1B2M, NAGLU, ALB
24iohexol469.1ALB, B2M, NAGLU
25fosinopril46 1210.1ALB, CRP
26sevoflurane52 46 1211.1B2M, ALB, NAGLU
27calcium carbonate469.0CALCA, B2M
28gamma globulin469.0ALB, CRP, B2M
29pentosidine469.0B2M, ALB, CRP
30dmsa469.0CRP, NAGLU, B2M, CALCA
31polysulfone469.0CRP, B2M, ALB
32vitamin b12468.9ALB, B2M, CRP
33citrate468.9ALB, CRP, UMOD, NAGLU
34captopril46 62 52 30 1212.9B2M, CALCA, ALB
35homocysteine46 259.9NAGLU, ALB, CRP
36urea46 25 1210.7ALB, NAGLU, B2M, UMOD
37mannitol46 129.6ALB, CRP, NAGLU, B2M
38vitamin a46 25 1210.6NAGLU, ALB, CRP, B2M
39phosphorus468.6ALB, CALCA, NAGLU, B2M
40vitamin d468.5NAGLU, ALB, CALCA, B2M
4125-hydroxyvitamin d468.5CRP, ALB, B2M, CALCA
42sodium46 259.5ALB, NAGLU, B2M, UMOD
43iron46 259.5NAGLU, CRP, ALB, B2M
44uric acid46 259.3NAGLU, B2M, ALB, UMOD, CRP
45aspartate468.3CRP, ALB, NAGLU, B2M
46cysteine468.2NAGLU, CXCR1, ALB, UMOD, B2M
47glucose468.2CRP, ALB, UMOD, B2M, NAGLU
48lactate468.1CRP, ALB, CALCA, NAGLU, B2M
49creatinine467.8ALB, CALCA, UMOD, NAGLU, B2M, CRP
50calcium46 52 25 1210.3ALB, CALCA, UMOD, CXCR1, CRP, NAGLU

GO Terms for genes affiliated with Pyelonephritis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.3ALB, UMOD, NAGLU, B2M
2extracellular regionGO:0055767.8B2M, CALCA, ALB, CRP
3extracellular spaceGO:0056157.1CRP, ALB, CALCA, UMOD, CPN1, B2M

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor internalizationGO:0316239.4CALCA, CXCR1
2response to organic substanceGO:0100339.3ALB, UMOD
3inflammatory responseGO:0069549.1CRP, CALCA, CXCR1
4retina homeostasisGO:0018958.7ALB, B2M

Products for genes affiliated with Pyelonephritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyelonephritis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet