MCID: PYL005
MIFTS: 57

Pyelonephritis malady

Summaries for Pyelonephritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pyelonephritis (from Greek πήληξ – pyelum, meaning \"renal pelvis\", νεφρός – nephros,... more...

MalaCards: Pyelonephritis, also known as unspecified pyelonephritis nos, is related to acute pyelonephritis and chronic pyelonephritis. An important gene associated with Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are Selected targets of HNF1 and Chemokine receptors bind chemokines. The compounds uric acid and pentosidine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Pyelonephritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

pyelonephritis 8 10 44 60
unspecified pyelonephritis nos 8
pyelonephritis, unspecified 8
pyelonephritis unspecified 8
pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:11400
ICD9CM27 590.80
MeSH34 D011704
NCIt39 C34965

Related Diseases for Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

Acute Pyelonephritis Chronic Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis31.7CXCR1, NAGLU, CRP
2chronic pyelonephritis31.5NAGLU, UMOD, B2M
3hypertension30.7CRP, ADM, ALB
4cystitis30.7UMOD, NAGLU
5vesicoureteral reflux30.6UMOD, NAGLU, AMBP
6hydronephrosis30.5NAGLU
7bacteriuria30.5CRP, UMOD
8hepatitis30.5UGT1A1, CXCL10
9glomerulonephritis30.5AMBP, UMOD, B2M, ALB, NAGLU
10amyloidosis30.4CRP, B2M, ALB
11diabetes mellitus30.3GOT1, FBP1, B2M, UMOD, NAGLU, AMBP
12nephrolithiasis30.2UMOD
13nephrotic syndrome30.2AMBP, ALB, B2M, NAGLU
14hepatitis a30.2GOT1
15osteomyelitis30.1CRP
16chronic kidney failure30.1AQP2, ADM, ALB, UMOD, B2M, CRP
17proteinuria30.1ALB, NAGLU, CRP, UMOD, AMBP, B2M
18pneumonia30.1ADM, CRP, CXCL10, CXCR2, NAGLU
19adenocarcinoma30.1AMBP, ADM, UGT1A1, CXCL10, CXCR1, CXCR2
20urinary tract obstruction30.0AQP2
21acute kidney failure30.0AMBP, NAGLU, ALB, UMOD, B2M
22arthritis30.0B2M, AMBP, ALB, CXCL10, CXCR2, CXCR1
23thrombocytopenia29.9ALB, GOT1
24rheumatoid arthritis29.9AMBP, B2M, CXCL10, NAGLU, NAMPT, CXCR2
25systemic lupus erythematosus29.7CRP
26kawasaki disease29.7ADM, CRP
27pancreatitis29.7GOT1, CRP, ALB
28neutropenia29.7CXCL10, CXCR1, UGT1A1
29leukemia29.7NAMPT, CXCR1, B2M
30influenza29.7CXCL10, LPXN, LGALS7
31essential hypertension29.7AQP2, ADM, ALB, NAGLU, LPXN
32myeloma29.7ALB, NAGLU, B2M, UMOD
33uremia29.7AMBP, CRP, B2M, ALB
34breast cancer29.7CXCL10, NAGLU, AMBP, UGT1A1, NAMPT, CXCR1
35hypercalcemia29.7ALB, B2M
36bronchitis29.7CRP
37xanthogranulomatous pyelonephritis11.1
38pyelitis10.4
39renal cell carcinoma10.3
40acute cystitis10.3
41urethritis10.2
42interstitial nephritis10.2
43pseudohypoaldosteronism10.2
44kidney disease10.2
45lipomatosis10.2
46perinephritis10.1
47malignant hypertension10.1
48prostatitis10.1
49tuberculosis10.1
50pyuria10.1

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to pyelonephritis

Clinical Features for Pyelonephritis

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Drugs & Therapeutics for Pyelonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pyelonephritis

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Anatomical Context for Pyelonephritis

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32MalaCards
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MalaCards organs/tissues related to Pyelonephritis:

32
Kidney, Testes, Liver, Prostate, Colon, Cortex, Spinal cord, Bone, Brain, Ovary, B cells, T cells, Monocytes, Breast, Thyroid, Heart, Spleen, Lung, Lymph node, Whole blood

Animal Models for Pyelonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2AQP2, ADM, ALB, CXCR2, NAGLU, UMOD
2MP:00053769.9CXCL10, AQP2, ALB, CXCR2, NAMPT, HCCS
3MP:00053879.7CPN1, UMOD, ADM, CXCL10, CXCR2, NAMPT

Publications for Pyelonephritis

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50PubMed
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Articles related to Pyelonephritis:

(show top 50)    (show all 1534)
idTitleAuthorsYear
1
Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial. (22726802)
2012
2
Chronic prostatitis, cystitis, pyelonephritis, and balanoposthitis in a cat. (21673330)
2011
3
Emphysematous pyelonephritis and pneumo-vena cava. (21293779)
2010
4
The effect of an observation unit on the rate of ED admission and discharge for pyelonephritis. (20637383)
2010
5
Pharmacotherapy of lower urinary tract infections and pyelonephritis in children. (19663608)
2009
6
Measuring appropriate use of antibiotics in pyelonephritis in Belgian hospitals. (19157631)
2009
7
Emphysematous pyelonephritis successfully treated by early intervention using a renoureteral catheter. (19554406)
2009
8
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. (18828054)
2008
9
Evaluation of reflux nephropathy, pyelonephritis and renal dysplasia. (18071688)
2008
10
Iatrogenic emphysematous pyelonephritis in a renal transplant patient. (18507751)
2008
11
Successful treatment of vancomycin-resistant Enterococcus faecium pyelonephritis with daptomycin during pregnancy. (18349306)
2008
12
Percutaneous manual aspiration embolectomy of renal vein thrombosis due to acute pyelonephritis. (17533548)
2007
13
Resolution of cortical lesions on serial renal scans in children with acute pyelonephritis. (17171352)
2007
14
An unusual case of xanthogranulomatous pyelonephritis in an immunosuppressed patient with systemic lupus erythematosus. (17238048)
2007
15
Xanthogranulomatous pyelonephritis in adults: clinical and radiological findings in diffuse and focal forms. (17662737)
2007
16
Xanthogranulomatous pyelonephritis with a renocolic fistula caused by a parapelvic cyst. (16734865)
2006
17
Risk factors associated with acute pyelonephritis in healthy women. (15630106)
2005
18
Quantitative analysis of 99mTc-DMSA during acute pyelonephritis for prediction of long-term renal scarring. (14960649)
2004
19
Xanthogranulomatous pyelonephritis: a retrospective study of 10 cases and review of the literature. (18209396)
2001
20
Oral ceftibuten switch therapy for acute pyelonephritis in children. (11529382)
2001
21
US and CT findings of xanthogranulomatous pyelonephritis. (11483422)
2001
22
Isepamicin versus amikacin for the treatment of acute pyelonephritis in children. (10717501)
2000
23
CT and 99mTc-DMSA scintigraphy in adult acute pyelonephritis: a comparative study. (10966194)
2000
24
Xanthogranulomatous pyelonephritis with bilateral nephrocutaneous fistulae. (9313324)
1997
25
Hydrocortisol, parathyroid hormone and calcitonin in blood of patients with chronic pyelonephritis and nephrosclesosis]. (9471316)
1997
26
Focal xanthogranulomatous pyelonephritis presenting as renal tumour in children. Case report with a review of the literature. (8837258)
1996
27
Virulence factors and pap genotype in Escherichia coli isolates from women with acute pyelonephritis, with or without bacteremia. (8105983)
1993
28
Comparison of ciprofloxacin with netilmicin for the treatment of acute pyelonephritis. (1553112)
1992
29
Focal xanthogranulomatous pyelonephritis associated with renal cell carcinoma. (1546425)
1992
30
Focal xanthogranulomatous pyelonephritis: diagnostic and therapeutic aspects. (1413314)
1992
31
Acute pyelonephritis. Preventing complications through prompt diagnosis and proper therapy. (1738745)
1992
32
Xanthogranulomatous pyelonephritis with nephrocutaneous fistula at the knee. (2070215)
1991
33
A novel use of fine-needle aspiration biopsy: documentation of acute pyelonephritis of the transplanted kidney. (3043822)
1988
34
Urographic renal size in acute pyelonephritis in childhood. (2965897)
1988
35
Acute pyelonephritis complicated by respiratory insufficiency. A case report. (3735267)
1986
36
Identical twins with identical vesicoureteric reflux: chronic pyelonephritis in one. (6404409)
1983
37
Xanthogranulomatous pyelonephritis. An immunohistochemical and ultrastructural study on the occurrence of bacteria and bacterial antigen. (7324298)
1981
38
Current cases & concepts: xanthogranulomatous pyelonephritis. (262209)
1979
39
Xanthogranulomatous pyelonephritis in childhood. (950713)
1976
40
An ultrastructural study of the renal medulla in experimental acute pyelonephritis. (1099824)
1975
41
Xanthogranulomatous pyelonephritis. Angiographic evaluation. (4591220)
1974
42
Experimental lipid A-induced nephritis in the dog. A possible role of lipid A in the pathogenesis of abacterial chronic pyelonephritis. (4613655)
1974
43
The site of renal infection: pyelitis or pyelonephritis? (4595980)
1974
44
The relationship of vesico-ureteric reflux to urinary tract infection and chronic pyelonephritis-reflux nephropathy. (4783715)
1973
45
Xanthogranulomatous pyelonephritis. (5804197)
1969
46
Long-term treatment of chronic pyelonephritis. (6037470)
1967
47
UROLOGICAL SURVEY OF CHRONIC PYELONEPHRITIS AND RECURRENT URINARY INFECTION WITHOUT OBSTRUCTION. (14269350)
1965
48
Leukemoid reaction in Escherichia coli pyelonephritis. Report of two cases and review of the literature. (13761739)
1961
49
Clinical recognition of chronic pyelonephritis. (13342998)
1956
50
Pyelitis or acute pyelonephritis. (14933263)
1952

Genetic Variations for Pyelonephritis

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Expression for genes affiliated with Pyelonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyelonephritis

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Pathways for genes affiliated with Pyelonephritis

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12EMD Millipore, 53Reactome
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Pathways related to Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ALB, CRP, UMOD
210.3CXCL10, CXCR1, CXCR2

Compounds for genes affiliated with Pyelonephritis

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.8B2M, UMOD
2pentosidine4410.8ALB, B2M
3iopentol4410.8ALB, NAGLU, B2M
4p-aminohippuric acid4410.8B2M, NAGLU, ALB
5mannitol44 1111.8ALB, NAGLU, CRP
6amikacin4410.8AMBP, B2M, NAGLU
7gamma globulin4410.8B2M, CRP, ALB
8endotoxin4410.7ADM, CXCR2
9vitamin a44 11 2412.7AMBP, NAGLU
1099mtc-dmsa4410.7AMBP, CRP, B2M, NAGLU
11dmsa4410.7CRP, AMBP, B2M, NAGLU
12iohexol4410.7AMBP, ALB, B2M, NAGLU
13calcium oxalate4410.7AMBP, UMOD, NAGLU
14inulin4410.7NAGLU, ALB, B2M, AMBP
15sevoflurane44 1111.7NAGLU, ALB, B2M
16perindopril44 49 1112.7NAGLU, ALB, CRP
17cxcl62810.7CXCR2, CXCR1
18cxcl82810.7CXCR2, CXCR1
19neopterin4410.7B2M, CRP, NAGLU, CXCL10
20[125i]cxcl8 (human)2810.7CXCR1, CXCR2
21losartan44 49 28 1113.7CRP, ADM, NAGLU, ALB, UGT1A1
22cxcl12810.7CXCR2, CXCR1
23mercury4410.7NAGLU, AQP2, AMBP
24potassium44 11 2412.7AMBP, NAGLU, ADM, AQP2
25urea44 11 2412.6B2M, AQP2, ALB, NAGLU, AMBP, UMOD
26hydrochlorothiazide44 49 28 11 2414.6CRP, ALB, AQP2
27polysulfone4410.6B2M, CRP, ALB
28homocysteine44 2411.6CRP, ALB, NAGLU, ADM
29aspartate4410.6NAGLU, ALB, B2M, UGT1A1, AMBP
30nh4cl4410.6AMBP, B2M
31sodium44 2411.6ADM, UMOD, B2M, NAGLU, ALB, AMBP
32lactate4410.6ALB, CRP, AMBP, B2M, ADM, NAGLU
33enalapril44 49 1112.6AMBP, NAGLU, ALB
34polyether sulfone4410.5ALB, B2M
35groalpha4410.5CXCR1, CXCR2, CXCL10
36cholesterol44 28 11 2413.5NAGLU, B2M, CRP, LPXN, UGT1A1, CXCL10
37creatinine4410.5AMBP, UMOD, CRP, B2M, NAGLU, NAMPT
38cysteine4410.5UMOD, B2M, ADM, CXCR1, CXCR2, NAGLU
39fibrinogen4410.4AMBP, NAMPT, CXCR2, ALB, CRP
40citrate4410.4ALB, NAGLU, CRP, UMOD
41desmopressin44 59 28 1113.4B2M, AQP2, NAGLU
42retinoic acid44 2411.4ADM, CXCR1, B2M, UGT1A1, LGALS7, CXCL10
43alanine4410.4CRP, UGT1A1, AMBP, B2M, NAGLU, CXCL10
44lipid4410.4CRP, LPXN, AQP2, AMBP, CXCL10, ALB
45glucose4410.3NAGLU, FBP1, AQP2, AMBP, UMOD, LPXN
46calcium44 49 11 2413.3UMOD, CRP, NAGLU, B2M, CXCL10, CXCR1
47nitroglycerin44 1111.3B2M, ADM, CRP
48hyaluronic acid44 2411.3B2M, NAGLU, ALB, AMBP
49ifosfamide44 1111.2AMBP, B2M, NAGLU
50steroid449.9NAGLU, AMBP, UGT1A1, B2M, ADM, AQP2

GO Terms for genes affiliated with Pyelonephritis

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16Gene Ontology
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Cellular components related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1CPN1, ADM, ALB, CXCL10, B2M, CRP

Biological processes related to Pyelonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.6CXCR1, CXCR2
2response to starvationGO:04259410.5UGT1A1, ADM, AQP2
3heme catabolic processGO:04216710.5UGT1A1, AMBP
4receptor internalizationGO:03162310.5CXCR2, CXCR1, ADM
5response to lipopolysaccharideGO:03249610.5AQP2, ADM, CXCL10, UGT1A1
6response to glucocorticoid stimulusGO:05138410.4GOT1, ADM, CPN1
7dendritic cell chemotaxisGO:00240710.4CXCR1, CXCR2
8female pregnancyGO:00756510.3AQP2, ADM, AMBP
9agingGO:00756810.2CRP, ADM, AQP2
10inflammatory responseGO:00695410.0CXCL10, CXCR1, CXCR2, CRP

Molecular functions related to Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.4CXCR1, CXCR2
2interleukin-8 receptor activityGO:00491810.1CXCR1, CXCR2

Products for genes affiliated with Pyelonephritis

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Sources for Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet