MCID: PYL005
MIFTS: 52

Pyelonephritis malady

Categories: Nephrological diseases

Aliases & Classifications for Pyelonephritis

Summaries for Pyelonephritis

MalaCards based summary : Pyelonephritis is related to xanthogranulomatous pyelonephritis and hepatitis. An important gene associated with Pyelonephritis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and neutrophil, and related phenotypes are cardiovascular system and immune system

Wikipedia : 71 Pyelonephritis is an inflammation of the kidney tissue, calyces, and renal pelvis. It is commonly caused... more...

Related Diseases for Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
id Related Disease Score Top Affiliating Genes
1 xanthogranulomatous pyelonephritis 32.4 ACE CRP IL6 TNF
2 hepatitis 30.1 IL10 IL6 TNF
3 carbuncle 29.3 CXCL8 IL1B IL6
4 lupus erythematosus 29.2 ACE CRP IL6
5 tuberculosis 28.9 ACE CCL2 IL10 IL1B IL6 TNF
6 rheumatoid arthritis 28.5 CCL2 CRP CXCL8 IL10 IL1B IL6
7 acute pyelonephritis 12.1
8 chronic pyelonephritis 12.1
9 cystinuria 11.2
10 cystitis 11.1
11 pyelitis 11.1
12 bacteriuria 11.1
13 acute cystitis 11.1
14 alport syndrome 10.8
15 hand-foot-uterus syndrome 10.7
16 urofacial syndrome 1 10.7
17 acute gonococcal cystitis 10.7
18 coloboma of iris 10.3 CRP IL6
19 capillary leak syndrome 10.3 ALB CRP CXCL8
20 shoulder impingement syndrome 10.3 ALB CRP IL6
21 labyrinthine bilateral reactive loss 10.3 ALB CXCL8 IL6
22 hyperlipoproteinemia type iv 10.2 ALB CRP IL6
23 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL10 IL6
24 cutaneous candidiasis 10.2 CCL2 CXCL8
25 multiple mitochondrial dysfunctions syndrome 10.2 CRP IL10 IL6
26 stiff-person syndrome 10.2 CCL2 CRP IL6
27 congenital dyserythropoietic anemia 10.2 ALB TNF
28 cryptosporidiosis 10.2 CCL2 IL6 PGF
29 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
30 appendiceal l-cell glucagon-like peptide producing tumor 10.2 CRP CXCL8 TLR4
31 glycogen storage disease viii 10.2 CRP CXCR1 TLR4
32 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
33 pyridoxal 5'-phosphate-dependent epilepsy 10.2 IL10 TNF
34 swine influenza 10.2 CRP IL6 TNF
35 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6 TNF
36 mixed mineral dust pneumoconiosis 10.2 CCL2 CRP CXCL8 IL6
37 esophagus lymphoma 10.2 CXCL8 IL6 TNF
38 acute necrotizing encephalitis 10.2 ALB CCL2 NAGLU
39 schwannoma of ureter 10.2 CCL2 CXCL8 CXCR1 IL6
40 coronary arterial fistulas 10.2 CXCL8 IL10 TLR4
41 autoimmune disease of central nervous system 10.2 CRP IL6 TNF
42 orthostatic proteinuria 10.2 CXCL8 IL6 TNF
43 dermatomycosis 10.2 ALB CRP TNF
44 hyperlucent lung 10.2 CCL2 CRP TLR4
45 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
46 hypertropia 10.1 ALB CRP TNF
47 carotenemia 10.1 CRP IL6 TNF
48 lacrimal system cancer 10.1 CRP CXCL8 IL10 IL6
49 oculomotor nerve paralysis 10.1 CXCL8 IL1B IL6
50 neurological manifestations of pompe disease 10.1 ALB CP

Comorbidity relations with Pyelonephritis via Phenotypic Disease Network (PDN): (show all 22)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, Type I Osteoporosis
Paralytic Ileus Protein-Energy Malnutrition
Schizophreniform Disorder Ureterolithiasis

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to Pyelonephritis

Symptoms & Phenotypes for Pyelonephritis

MGI Mouse Phenotypes related to Pyelonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 IL6 NAGLU PGF TLR4 TNF ACE
2 immune system MP:0005387 10.13 IL6 NAGLU PGF TLR4 TNF ACE
3 homeostasis/metabolism MP:0005376 10.11 IL10 IL1B IL6 PGF TLR4 TNF
4 hematopoietic system MP:0005397 10.1 ACE CP CXCR1 CXCR2 IL10 IL1B
5 liver/biliary system MP:0005370 9.81 ACE ALB CP CXCR2 IL10 IL6
6 integument MP:0010771 9.8 IL10 IL1B IL6 NAGLU PGF TLR4
7 neoplasm MP:0002006 9.61 ACE ALB CXCR2 IL10 IL1B IL6
8 vision/eye MP:0005391 9.23 CP CXCR2 IL10 IL6 NAGLU PGF

Drugs & Therapeutics for Pyelonephritis

Drugs for Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved Phase 4 79350-37-1 54362 5362065
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
6
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3 67-20-9 5353830
7
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
9
Cilastatin Approved Phase 4,Phase 2 82009-34-5 5280454 6435415
10
Imipenem Approved Phase 4,Phase 2 74431-23-5 104838
11
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
12
Cefoxitin Approved Phase 4 35607-66-0 441199
13
Fosfomycin Approved Phase 4,Phase 2,Phase 3 23155-02-4 446987
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 54575, 6560146 143
16 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2
19 Antitubercular Agents Phase 4,Phase 3
20 HIV Protease Inhibitors Phase 4,Phase 2
21
protease inhibitors Phase 4,Phase 2
22 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
23 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
24 Fluoroquinolones Phase 4,Phase 2
25 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
26 Renal Agents Phase 4,Phase 3,Phase 2
27 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
28 Antimalarials Phase 4,Phase 3
29 Antiparasitic Agents Phase 4,Phase 3
30 Antiprotozoal Agents Phase 4,Phase 3
31 Folic Acid Antagonists Phase 4,Phase 3
32 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
33 Vitamin B Complex Phase 4,Phase 3
34 Lactams Phase 4
35 Folate Nutraceutical Phase 4,Phase 3
36 Vitamin B9 Nutraceutical Phase 4,Phase 3
37 Avibactam Approved Phase 3,Phase 2 1192500-31-4
38
Ceftazidime Approved Phase 3,Phase 2 78439-06-2 5481173
39
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
40
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
41
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
42
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
43
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
44
Ertapenem Approved, Investigational Phase 3,Phase 2 153832-46-3 150610
45
Colistin Approved Phase 3 1264-72-8, 1066-17-7 5311054
46
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
47
Tigecycline Approved Phase 3 220620-09-7 5282044
48
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
49
Ceftibuten Approved Phase 3 97519-39-6 5282241 5282242
50
Cefepime Approved Phase 3 88040-23-7 5479537

Interventional clinical trials:

(show top 50) (show all 87)
id Name Status NCT ID Phase
1 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4
2 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4
4 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4
5 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
6 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4
7 Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aerugi Completed NCT00481689 Phase 4
8 A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections Completed NCT01763008 Phase 4
9 Pharmacokinetics of Ciprofloxacin in Pediatric Patients Recruiting NCT02598362 Phase 4
10 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Recruiting NCT02474706 Phase 4
11 Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial Recruiting NCT03151603 Phase 4
12 The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria Recruiting NCT01871753 Phase 4
13 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Not yet recruiting NCT03179384 Phase 4
14 Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin Terminated NCT00239161 Phase 4
15 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3
16 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3
17 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281 Phase 3
18 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00210990 Phase 3
19 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00229021 Phase 3
20 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3
21 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis Completed NCT01345929 Phase 3
22 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3
23 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3
24 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3
25 Efficacy, Safety, Tolerability of Carbavance Compared to Piperacillin/Tazobactam in Complicated Urinary Tract Infections (cUTIs), Including Acute Pyelonephritis (AP), in Adults Completed NCT02166476 Phase 3
26 A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED) Completed NCT00379964 Phase 3
27 A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048) Completed NCT00379951 Phase 3
28 A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections Completed NCT00258089 Phase 3
29 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3
30 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3
31 Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014) Recruiting NCT02728089 Phase 3
32 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
33 Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae, in Adults Recruiting NCT02168946 Phase 3
34 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Active, not recruiting NCT02753946 Phase 2, Phase 3
35 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3
36 A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections Terminated NCT01110408 Phase 3
37 Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections Terminated NCT02302092 Phase 3
38 Efficacy of Antimicrobial Prophylaxis for Shock Wave Lithotripsy (SWL) on Reducing Urinary Tract Infection (UTI) Terminated NCT01873690 Phase 3
39 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3
40 Different Modes of Temperature Measurement in the Emergency Department Withdrawn NCT01801020 Phase 3
41 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
42 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2
43 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2
44 Study of Plazomicin (ACHN-490) Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis Completed NCT01096849 Phase 2
45 Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections Completed NCT00921024 Phase 2
46 A Study of Efficacy/Safety of Intravenous S-649266 Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections Completed NCT02321800 Phase 2
47 Study of the Safety, Tolerability, and Efficacy of MK-7655 + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for the Treatment of Complicated Urinary Tract Infection (cUTI) (MK-7655-003) Completed NCT01505634 Phase 2
48 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2
49 Preventing Urinary Tract Infection Post-Surgery Completed NCT01346774 Phase 2
50 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Recruiting NCT02537847 Phase 2

Search NIH Clinical Center for Pyelonephritis

Cochrane evidence based reviews: pyelonephritis

Genetic Tests for Pyelonephritis

Genetic tests related to Pyelonephritis:

id Genetic test Affiliating Genes
1 Pyelonephritis 29

Anatomical Context for Pyelonephritis

MalaCards organs/tissues related to Pyelonephritis:

39
Kidney, Testes, Neutrophil, Liver, Prostate, Colon, Lung

Publications for Pyelonephritis

Articles related to Pyelonephritis:

(show top 50) (show all 1731)
id Title Authors Year
1
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
2
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
3
Eliciting renal tenderness by sonopalpation in diagnosing acute pyelonephritis. ( 28050884 )
2017
4
Pyelonephritis due to Brucella species: true clinical entity or ghost disease? ( 27909584 )
2017
5
Definitions of Complicated Urinary Tract Infection and Pyelonephritis. ( 27986671 )
2017
6
Concurrent Diffuse Pyelonephritis and Prostatitis: Discordant Findings on Sequential FDG PET/CT and 67Ga SPECT/CT Imaging. ( 27824318 )
2017
7
Emphysematous Pyelonephritis Treated with Vacuum Sealing Drainage. ( 28091422 )
2017
8
AJKD Atlas of Renal Pathology: Chronic Pyelonephritis. ( 27664481 )
2016
9
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. ( 27370410 )
2016
10
Primary kidney parenchyma squamous cell carcinoma mimicking xanthogranulomatous pyelonephritis: A case report. ( 26998145 )
2016
11
Pyelonephritis following phenazopyridine use. ( 27939517 )
2016
12
Multiple Renal Abscesses due to ESBL Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Causing Acute Pyelonephritis and Bacteremia: A Case Report with a Good Outcome (No Drainage Required). ( 28018690 )
2016
13
Are the unenhanced and excretory CT phases necessary for the evaluation of acute pyelonephritis? ( 27563103 )
2016
14
Acute pyelonephritis in transplanted kidneys: can diffusion-weighted magnetic resonance imaging be useful for diagnosis and follow-up? ( 27039324 )
2016
15
Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts. ( 27059742 )
2016
16
Acute pyelonephritis resulting in intense vascular blush during dynamic renal scintigraphy. ( 26917903 )
2016
17
Retrograde pyelonephritis and lumbar spondylitis as a result of Salmonella typhi in a typeA 2 diabetes patient with neurogenic bladder. ( 27330732 )
2016
18
Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis. ( 27069830 )
2016
19
Acute Pyelonephritis with Bacteremia Caused by Enterococcus hirae: A Rare Infection in Humans. ( 27127665 )
2016
20
Health care-associated acute pyelonephritis is associated with inappropriate empiric antibiotic therapy in the ED. ( 27130586 )
2016
21
Case report: Xanthogranulomutous pyelonephritis presenting as "Wilms' tumor". ( 27388196 )
2016
22
Septic lung metastasis in xanthogranulomatous pyelonephritis. ( 27578950 )
2016
23
Xanthogranulomatous pyelonephritis. ( 27307431 )
2016
24
Fluoroquinolone-Resistant and Extended-Spectrum I^-Lactamase-Producing Escherichia coli Infections in Patients with Pyelonephritis, United States(1). ( 27532362 )
2016
25
Emphysematous pyelonephritis. ( 26988263 )
2016
26
Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population-Based Case-Control Study in Taiwan. ( 27539679 )
2016
27
RE: Emphysematous pyelonephritis: Is nephrectomy warranted? ( 27141208 )
2016
28
An unusual presentation of xanthogranulomatous pyelonephritis: psoas abscess with reno-colic fistula. ( 27471599 )
2016
29
Rapid detection of amoxicillin-susceptible Escherichia coli in fresh uncultured urine: a new tool to limit the use of broad-spectrum empirical therapy of community-acquired pyelonephritis. ( 27211827 )
2016
30
Pyelonephritis Caused by Salmonella Anatum: An Unusual Case. ( 26982968 )
2016
31
Reverse kinetics of angiopoietin-2 and endotoxins in acute pyelonephritis: Implications for anti-inflammatory treatment? ( 26844659 )
2016
32
Concurrent emphysematous pyelonephritis, cystitis, and iliopsoas abscess from discitis in a diabetic woman. ( 27637417 )
2016
33
Incidence, risk factors, and the impact of allograft pyelonephritis on renal allograft function. ( 27380002 )
2016
34
Diagnostic performance of initial serum lactate for predicting bacteremia in female patients with acute pyelonephritis. ( 27133532 )
2016
35
Iliopsoas abscess caused by chronic urolithiasis and pyelonephritis. ( 27974344 )
2016
36
Renal tuberculosis presenting as acute pyelonephritis - A rarity. ( 27865246 )
2016
37
The gender specific risk factors for prolonged hospitalization due to acute pyelonephritis in a Japanese tertiary emergency center. ( 26712583 )
2016
38
Double J stenting: A rewarding option in the management of emphysematous pyelonephritis. ( 27453644 )
2016
39
Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli. ( 26767868 )
2016
40
Renal Sarcoidosis Mimicking Xanthogranulomatous Pyelonephritis. ( 27590254 )
2016
41
Author's reply to the letter to the editor regarding "Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume". ( 27116249 )
2016
42
Xanthogranulomatous Pyelonephritis. ( 27743436 )
2016
43
Usefulness of analytical parameters in the management of paediatric patients with suspicion of acute pyelonephritis. Is procalcitonin reliable? ( 27329559 )
2016
44
Ceftazidime-avibactam Versus Doripenem for the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis: RECAPTURE, a Phase 3 Randomized Trial Program. ( 27313268 )
2016
45
Co-existing malakoplakia and xanthogranulomatous pyelonephritis of kidney: Two different spectrum of same disease process. ( 27141206 )
2016
46
Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume. ( 26868147 )
2016
47
Pyelonephritis with bacteremia caused by Listeria monocytogenes: A case report. ( 27600175 )
2016
48
AJKD Atlas of Renal Pathology: Acute Pyelonephritis. ( 27664480 )
2016
49
Outpatient treatment in women with acute pyelonephritis after visiting emergency department. ( 27534596 )
2016
50
Xanthogranulomatous pyelonephritis presenting as a pseudotumour. ( 26858786 )
2016

Variations for Pyelonephritis

Expression for Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for Pyelonephritis

Pathways related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CRP CXCL8 CXCR1 CXCR2 IL10
2
Show member pathways
13.84 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
3
Show member pathways
13.66 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
4
Show member pathways
13.38 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
5
Show member pathways
13.31 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
6
Show member pathways
13.02 CCL2 CP CXCL8 IL1B IL6 TLR4
7
Show member pathways
12.89 ACE CCL2 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.85 CXCL8 IL10 IL1B IL6 TNF
9
Show member pathways
12.83 CCL2 CXCL8 IL1B IL6 TLR4 TNF
10
Show member pathways
12.71 IL1B IL6 PGF TLR4 TNF
11
Show member pathways
12.63 IL10 IL1B IL6 TLR4 TNF
12
Show member pathways
12.62 CCL2 IL10 IL1B IL6 TNF
13 12.52 CCL2 IL10 IL1B TNF
14
Show member pathways
12.47 CP CXCL8 CXCR1 CXCR2
15
Show member pathways
12.42 IL10 IL1B IL6 TNF
16
Show member pathways
12.39 CCL2 CXCL8 IL1B IL6 TNF
17
Show member pathways
12.36 ALB CCL2 CRP IL1B IL6 TNF
18
Show member pathways
12.32 CXCL8 IL1B IL6 TLR4 TNF
19
Show member pathways
12.28 CXCL8 IL6 TLR4 TNF
20
Show member pathways
12.28 IL10 IL1B TLR4 TNF
21 12.28 IL10 IL1B IL6 TLR4 TNF
22
Show member pathways
12.23 CXCL8 IL1B IL6 TLR4 TNF
23 12.22 CXCL8 IL10 IL1B IL6 TNF
24
Show member pathways
12.21 CXCL8 IL10 IL1B IL6 TNF
25
Show member pathways
12.07 CCL2 CXCL8 CXCR1 CXCR2
26 12 CCL2 IL1B IL6 TNF
27
Show member pathways
12 IL10 IL1B IL6 TLR4 TNF
28 11.99 CCL2 CXCL8 IL1B IL6 TLR4 TNF
29 11.96 CCL2 CXCL8 IL1B IL6 TNF
30 11.94 CXCL8 IL1B TLR4 TNF
31 11.94 CCL2 CXCL8 IL10 IL1B IL6 TNF
32 11.93 CXCL8 IL1B IL6
33
Show member pathways
11.91 IL1B IL6 TLR4
34 11.89 CXCL8 IL1B IL6 TLR4
35 11.88 IL1B IL6 TNF
36
Show member pathways
11.86 CXCL8 IL6 TLR4
37 11.83 IL10 IL1B IL6 TNF
38 11.83 CXCL8 IL10 IL1B IL6 TLR4 TNF
39 11.79 IL10 IL1B TNF
40 11.79 IL10 IL6 TLR4 TNF
41
Show member pathways
11.73 CXCL8 IL1B IL6 TNF
42 11.69 CCL2 CXCL8 IL1B IL6 TLR4 TNF
43 11.67 CCL2 CXCL8 IL1B IL6 TNF
44 11.6 CXCL8 IL1B IL6 TLR4 TNF
45 11.59 CCL2 IL1B TLR4 TNF
46 11.58 CXCL8 CXCR1 IL6
47 11.52 IL1B IL6 TNF
48 11.51 CXCL8 IL10 IL1B IL6 TLR4 TNF
49 11.43 IL10 IL1B IL6 TNF
50 11.41 ACE CCL2 TLR4

GO Terms for Pyelonephritis

Cellular components related to Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACE ALB CCL2 CP CRP CXCL8
2 external side of plasma membrane GO:0009897 9.46 ACE IL6 TLR4 TNF
3 extracellular space GO:0005615 9.36 ACE ALB CCL2 CP CRP CXCL8

Biological processes related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 IL6 TLR4 TNF
2 chemotaxis GO:0006935 9.93 CCL2 CXCL8 CXCR1 CXCR2
3 cellular response to tumor necrosis factor GO:0071356 9.9 CCL2 CXCL8 IL6
4 positive regulation of angiogenesis GO:0045766 9.9 CXCL8 IL1B PGF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TLR4 TNF
6 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
7 response to lipopolysaccharide GO:0032496 9.88 CCL2 IL10 IL1B IL6 TLR4
8 cellular response to interleukin-1 GO:0071347 9.87 CCL2 CXCL8 IL6
9 cellular response to organic cyclic compound GO:0071407 9.87 CCL2 IL1B TNF
10 defense response to Gram-positive bacterium GO:0050830 9.86 CRP IL6 TNF
11 positive regulation of endothelial cell proliferation GO:0001938 9.85 CCL2 IL10 PGF
12 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TNF
13 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL1B IL6 TNF
14 humoral immune response GO:0006959 9.83 CCL2 IL6 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.82 IL1B TLR4 TNF
16 response to glucocorticoid GO:0051384 9.81 CCL2 IL10 IL6 TNF
17 receptor internalization GO:0031623 9.8 CXCL8 CXCR1 CXCR2
18 cellular response to estradiol stimulus GO:0071392 9.8 CCL2 IL10 IL6
19 chemokine-mediated signaling pathway GO:0070098 9.8 CCL2 CXCL8 CXCR1 CXCR2
20 immune response GO:0006955 9.8 CCL2 CXCL8 IL10 IL1B IL6 TLR4
21 response to bacterium GO:0009617 9.77 CCL2 IL6 TLR4
22 protein kinase B signaling GO:0043491 9.76 CCL2 IL1B TNF
23 neutrophil chemotaxis GO:0030593 9.76 CCL2 CXCL8 CXCR2 IL1B
24 positive regulation of interleukin-8 production GO:0032757 9.74 IL1B TLR4 TNF
25 negative regulation of interleukin-6 production GO:0032715 9.73 IL10 TLR4 TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
28 cellular response to hepatocyte growth factor stimulus GO:0035729 9.71 IL10 IL6
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR4
30 induction of positive chemotaxis GO:0050930 9.71 CXCL8 PGF
31 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
32 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
33 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR4 TNF
34 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
35 neutrophil mediated immunity GO:0002446 9.7 ACE IL6
36 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
37 neutrophil activation GO:0042119 9.7 CXCL8 CXCR2
38 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR4 TNF
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
40 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 TLR4
42 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
44 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TLR4 TNF
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.66 IL6 TNF
46 regulation of vascular endothelial growth factor production GO:0010574 9.65 CCL2 IL6
47 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
48 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
49 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B IL6 TLR4 TNF
50 receptor biosynthetic process GO:0032800 9.61 IL10 TNF

Molecular functions related to Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
2 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 interleukin-8 receptor activity GO:0004918 8.96 CXCR1 CXCR2

Sources for Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....