MCID: PYL005
MIFTS: 52

Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Pyelonephritis

Summaries for Pyelonephritis

MalaCards based summary : Pyelonephritis is related to xanthogranulomatous pyelonephritis and carbuncle. An important gene associated with Pyelonephritis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and immune system

Wikipedia : 72 Pyelonephritis is an inflammation of the kidney tissue, calyces, and renal pelvis. It is commonly caused... more...

Related Diseases for Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 481)
id Related Disease Score Top Affiliating Genes
1 xanthogranulomatous pyelonephritis 32.5 ACE ALB CRP IL6 TNF
2 carbuncle 29.9 CXCL8 IL1B IL6
3 renal fibrosis 29.1 ACE IL6 PGF TNF
4 melioidosis 28.9 IL10 IL6 TLR4 TNF
5 systemic lupus erythematosus 28.0 ALB CCL2 CRP IL10 IL6 TNF
6 lymphoma 27.8 ACE ALB IL10 IL1B IL6 TNF
7 rheumatoid arthritis 27.3 CCL2 CRP CXCL8 IL10 IL1B IL6
8 acute pyelonephritis 12.1
9 chronic pyelonephritis 12.1
10 cystinuria 11.2
11 cystitis 11.1
12 pyelitis 11.1
13 bacteriuria 11.1
14 acute cystitis 11.1
15 collagenopathy type 2 alpha 1 10.8 CRP IL6
16 alport syndrome 10.8
17 crystal arthropathies 10.8 CRP IL6
18 shoulder impingement syndrome 10.7 CRP IL6
19 urofacial syndrome 1 10.7
20 acute gonococcal cystitis 10.7
21 cystitis cystica 10.7
22 hand-foot-uterus syndrome 10.7
23 odontoma-dysphagia syndrome 10.7
24 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
25 cytomegalovirus retinitis 10.7 CCL2 CXCL8
26 smarca4-deficient sarcoma of thorax 10.7 IL6 TNF
27 small cell lung cancer, adult 10.7 CRP CXCL8
28 aortic arch interruption 10.6 IL6 TNF
29 capillary leak syndrome 10.6 ALB CRP CXCL8
30 congenital dyserythropoietic anemia 10.6 ALB TNF
31 cutaneous leishmaniasis 10.6 IL6 TNF
32 thymus clear cell carcinoma 10.6 CRP CXCL8 TLR4
33 glycogen storage disease viii 10.6 CRP CXCR1 TLR4
34 labyrinthine bilateral reactive loss 10.6 ALB CXCL8 IL6
35 hyperlipoproteinemia type iv 10.6 ALB CRP IL6
36 prothrombin thrombophilia 10.6 IL1B TLR4
37 epstein-barr virus hepatitis 10.6 CRP IL6 TNF
38 spirillary rat-bite fever 10.6 CXCL8 IL6 TNF
39 pasteurellosis 10.5 CXCL8 IL6 TNF
40 flinders island spotted fever 10.5 CCL2 CXCL8
41 spondylocostal dysostosis 4 10.5 TLR4 TNF
42 chronic endophthalmitis 10.5 ALB CXCL8 IL6
43 oculomotor nerve paralysis 10.5 CXCL8 IL1B IL6
44 x-linked dominant intellectual disability-epilepsy syndrome 10.5 CRP IL1B IL6
45 common peroneal nerve lesion 10.5 CXCL8 IL1B IL6
46 dermatitis herpetiformis, familial 10.5 CCL2 CRP IL6
47 early congenital syphilis 10.5 CRP IL6 TNF
48 c1 inhibitor deficiency 10.5 CRP IL6 TNF
49 rickettsialpox 10.5 TLR4 TNF
50 hidradenitis 10.5 CRP CXCL8 IL1B

Comorbidity relations with Pyelonephritis via Phenotypic Disease Network (PDN): (show all 22)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, Type I Osteoporosis
Paralytic Ileus Protein-Energy Malnutrition
Schizophreniform Disorder Ureterolithiasis

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to Pyelonephritis

Symptoms & Phenotypes for Pyelonephritis

GenomeRNAi Phenotypes related to Pyelonephritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 ACE CXCL8 IL10 IL1B TNF UMOD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 ACE CXCL8 IL10 IL1B TNF UMOD

MGI Mouse Phenotypes related to Pyelonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.18 CXCR1 CXCR2 IL10 IL1B IL6 NAGLU
2 cardiovascular system MP:0005385 10.16 CRP CXCR2 IL10 IL1B IL6 NAGLU
3 homeostasis/metabolism MP:0005376 10.14 TNF UMOD ACE ALB CRP CXCR2
4 hematopoietic system MP:0005397 10.09 TNF ACE CXCR1 CXCR2 IL10 IL1B
5 adipose tissue MP:0005375 9.95 IL6 PGF TLR4 TNF UMOD ACE
6 liver/biliary system MP:0005370 9.92 ACE ALB CXCR2 IL10 IL6 NAGLU
7 neoplasm MP:0002006 9.91 ACE ALB CXCR2 IL10 IL1B IL6
8 renal/urinary system MP:0005367 9.7 ACE ALB CXCR2 IL6 NAGLU TLR4
9 skeleton MP:0005390 9.56 CXCR2 IL10 IL1B IL6 NAGLU TLR4
10 vision/eye MP:0005391 9.17 CXCR2 IL10 IL6 NAGLU PGF TLR4

Drugs & Therapeutics for Pyelonephritis

Drugs for Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved Phase 4 79350-37-1 54362 5362065
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
6
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3 67-20-9 5353830
7
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
9
Fosfomycin Approved Phase 4,Phase 2,Phase 3 23155-02-4 446987
10
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
11
Cilastatin Approved Phase 4,Phase 2 82009-34-5 5280454 6435415
12
Imipenem Approved Phase 4,Phase 2 74431-23-5, 64221-86-9 104838
13
Cephalexin Approved, Vet_approved Phase 4 15686-71-2 27447
14
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
15
Cefoxitin Approved Phase 4 35607-66-0 441199
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Antitubercular Agents Phase 4,Phase 3
22 Fluoroquinolones Phase 4,Phase 2
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
24 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
25 HIV Protease Inhibitors Phase 4,Phase 2
26
protease inhibitors Phase 4,Phase 2
27 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
28 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
29 Renal Agents Phase 4,Phase 3,Phase 2
30 Antimalarials Phase 4,Phase 3
31 Antiparasitic Agents Phase 4,Phase 3
32 Antiprotozoal Agents Phase 4,Phase 3
33 Folic Acid Antagonists Phase 4,Phase 3
34 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
35 Vitamin B Complex Phase 4,Phase 3
36 Lactams Phase 4
37 Amdinocillin Pivoxil Phase 4
38 Folate Nutraceutical Phase 4,Phase 3
39 Vitamin B9 Nutraceutical Phase 4,Phase 3
40 Uva-ursi Nutraceutical Phase 4
41
Ertapenem Approved, Investigational Phase 3,Phase 2 153832-46-3 150610
42 Avibactam Approved Phase 3,Phase 2 1192500-31-4
43
Ceftazidime Approved Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
44
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
45
Meropenem Approved, Investigational Phase 3,Phase 2,Phase 1 119478-56-7 64778 441130
46
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
47
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
48
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
49
Colistin Approved Phase 3 1264-72-8, 1066-17-7 5311054
50
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021

Interventional clinical trials:

(show top 50) (show all 91)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
2 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
5 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
6 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
7 Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aerugi Completed NCT00481689 Phase 4 Cipro XR (Ciprofloxacin, BAYQ3939)
8 A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections Completed NCT01763008 Phase 4 No intervention
9 Pharmacokinetics of Ciprofloxacin in Pediatric Patients Recruiting NCT02598362 Phase 4 ciprofloxacin
10 Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial Recruiting NCT03151603 Phase 4 Arctuvan;Fosfomycin;Placebo to Arctuvan;Placebo to Fosfomycin
11 The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria Recruiting NCT01871753 Phase 4
12 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Not yet recruiting NCT03179384 Phase 4 Ceftriaxone
13 Treating Pyelonephritis an Urosepsis With Pivmecillinam Not yet recruiting NCT03282006 Phase 4 pivmecillinam
14 Management of Sub-Clinical Bacteriuria in Pregnancy Not yet recruiting NCT03275623 Phase 4 Antibiotic
15 Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin Terminated NCT00239161 Phase 4 Levofloxacin
16 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
17 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
18 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
19 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281 Phase 3
20 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00210990 Phase 3 doripenem
21 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00229021 Phase 3 doripenum
22 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
23 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis Completed NCT01345929 Phase 3 CXA-201;Levofloxacin
24 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
25 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
26 Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014) Completed NCT02728089 Phase 3 MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g)
27 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
28 Efficacy, Safety, Tolerability of Carbavance Compared to Piperacillin/Tazobactam in Complicated Urinary Tract Infections (cUTIs), Including Acute Pyelonephritis (AP), in Adults Completed NCT02166476 Phase 3 Carbavance;Piperacillin/tazobactam;Levofloxacin;Saline
29 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
30 A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED) Completed NCT00379964 Phase 3 caspofungin acetate
31 A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048) Completed NCT00379951 Phase 3 ertapenem sodium
32 A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections Completed NCT00258089 Phase 3 Levofloxacin
33 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3 Bisphosphonate;Placebo
34 Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae, in Adults Completed NCT02168946 Phase 3 Carbavance;Best Available Therapy
35 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
36 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
37 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
38 A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections Terminated NCT01110408 Phase 3 Doripenem;Doripenem placebo;Cefepime;Cefepime placebo;Amoxicillin/clavulanate potassium
39 Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections Terminated NCT02302092 Phase 3 Flomoxef;Cefepime
40 Efficacy of Antimicrobial Prophylaxis for Shock Wave Lithotripsy (SWL) on Reducing Urinary Tract Infection (UTI) Terminated NCT01873690 Phase 3 Ciprofloxacin;Placebo
41 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3 Trimethoprim Sulfamethoxazole;placebo
42 Different Modes of Temperature Measurement in the Emergency Department Withdrawn NCT01801020 Phase 3
43 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Unknown status NCT02537847 Phase 2 Sitafloxacin;Ertapenem
44 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
45 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
46 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2 Finafloxacin 800 mg i.v. once daily;Finafloxacin placebo i.v. once daily;Finafloxacin 800 mg tablets once daily;Finafloxacin placebo tablets once daily;Ciprofloxacin 400 mg i.v. twice daily;Ciprofloxacin placebo i.v. twice daily;Ciprofloxacin 500 mg oral twice daily;Ciprofloxacin placebo oral twice daily
47 Study of Plazomicin (ACHN-490) Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis Completed NCT01096849 Phase 2 levofloxacin;plazomicin;placebo
48 Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections Completed NCT00921024 Phase 2 CXA-101;Ceftazidime
49 A Study of Efficacy/Safety of Intravenous S-649266 Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections Completed NCT02321800 Phase 2 S-649266;Imipenem/cilastatin
50 Study of the Safety, Tolerability, and Efficacy of MK-7655 + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for the Treatment of Complicated Urinary Tract Infection (cUTI) (MK-7655-003) Completed NCT01505634 Phase 2 MK-7655 250 mg;MK-7655 125 mg;imipenem/cilastatin 500 mg;Placebo to MK-7655;Ciprofloxacin

Search NIH Clinical Center for Pyelonephritis

Cochrane evidence based reviews: pyelonephritis

Genetic Tests for Pyelonephritis

Genetic tests related to Pyelonephritis:

id Genetic test Affiliating Genes
1 Pyelonephritis 29

Anatomical Context for Pyelonephritis

MalaCards organs/tissues related to Pyelonephritis:

39
Kidney, Testes, Liver, Neutrophil, Bone, Prostate, Spleen

Publications for Pyelonephritis

Articles related to Pyelonephritis:

(show top 50) (show all 1773)
id Title Authors Year
1
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
2
Pyelonephritis due to Brucella species: true clinical entity or ghost disease? ( 27909584 )
2017
3
Allergic Interstitial Nephritis Masquerading as Pyelonephritis in a Pediatric Patient With Crohn Disease. ( 28644363 )
2017
4
High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess. ( 28491170 )
2017
5
Distinctive inflammatory profile between acute focal bacterial nephritis and acute pyelonephritis in children. ( 28683358 )
2017
6
Emphysematous Pyelonephritis with Human Immunodeficiency Virus Infection. ( 28571161 )
2017
7
Concurrent Diffuse Pyelonephritis and Prostatitis: Discordant Findings on Sequential FDG PET/CT and 67Ga SPECT/CT Imaging. ( 27824318 )
2017
8
Interest of the Chosen Drug for Pyelonephritis: Does Size Matter? ( 28927547 )
2017
9
Role of antioxidant defence, renal toxicity markers and inflammatory cascade in disease progression of acute pyelonephritis in experimental rat model. ( 28578087 )
2017
10
Xanthogranulomatous Pyelonephritis Manifesting as a Nephrocutaneous Fistula in a 5-Year-Old Female. ( 28131924 )
2017
11
Emphysematous Pyelonephritis and Cystitis: Unusual Adverse Events during Concurrent Chemoradiotherapy for Lung Cancer. ( 28638336 )
2017
12
Xanthogranulomatous pyelonephritis presenting as acute pleuritic chest pain: a case report. ( 28399929 )
2017
13
Adenovirus pyelonephritis in the late posttransplant period. ( 28709609 )
2017
14
Electrolyte and Acid-Base Abnormalities in Infants with Community-Acquired Acute Pyelonephritis: Prospective Cross-Sectional Study. ( 28697495 )
2017
15
Overuse of Diagnostic Testing in the Management of Korean Patients with Acute Pyelonephritis. ( 28332347 )
2017
16
Acute Pyelonephritis - Correlation of Clinical Parameter with Radiological Imaging Abnormalities. ( 28764263 )
2017
17
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
18
Causal Neuro-immune Relationships at Patients with Chronic Pyelonephritis and Cholecystitis. Correlations between Parameters EEG, HRV and White Blood Cell Count. ( 28730179 )
2017
19
Imaging technologies in the diagnosis and treatment of acute pyelonephritis. ( 28525662 )
2017
20
Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum I^-lactamase-producing Escherichia coli. ( 28263710 )
2017
21
Deriving a management algorithm for emphysematous pyelonephritis: Can we rely on minimally invasive strategies or should we be opting for earlier nephrectomy? ( 28933020 )
2017
22
Splenic Abscess After Acute Pyelonephritis. ( 28215950 )
2017
23
Role of genetic mutations in development of immunological and clinical disorders in children with chronic pyelonephritis. ( 28343193 )
2017
24
Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery? ( 28660334 )
2017
25
Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )
2017
26
Usefulness of Blood Cultures and Radiologic Imaging Studies in the Management of Patients with Community-Acquired Acute Pyelonephritis. ( 28271650 )
2017
27
Xanthogranulomatous pyelonephritis presenting as a type IV renal cyst. ( 28522934 )
2017
28
Eliciting renal tenderness by sonopalpation in diagnosing acute pyelonephritis. ( 28050884 )
2017
29
Pyelonephritis in Japan caused by Salmonella enterica subspecies arizonae. ( 28838777 )
2017
30
Emphysematous Pyelitis: An Entity Distinct from Emphysematous Pyelonephritis. ( 28502342 )
2017
31
Spontaneous Nephrocutaneous Fistula: Rare Complication of Xanthogranulomatous Pyelonephritis. ( 28138432 )
2017
32
The climate impact on female acute pyelonephritis in Taiwan: AA population-based study. ( 28805597 )
2017
33
Transition Hand-Off from Inpatient to Outpatient Treatment of Acute Pyelonephritis in an Elderly Male. ( 28376986 )
2017
34
Emphysematous pyelonephritis: Changing trend of clinical spectrum, pathogenesis, management and outcome. ( 28717547 )
2017
35
Corticosteroids for renal scar prevention in children with acute pyelonephritis. ( 28404702 )
2017
36
A randomized controlled trial of sitafloxacin vs. ertapenem as a switchA therapy after treatment for acute pyelonephritis caused by extended-spectrum I^-lactamase-producing Escherichia coli: A pilot study. ( 28587974 )
2017
37
A Case of Xanthogranulomatous Pyelonephritis Associated with Renoduodenal Fistula. ( 28424736 )
2017
38
Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis. ( 28882930 )
2017
39
Acute leukemia masquerading as xanthogranulomatous pyelonephritis. ( 28479773 )
2017
40
Clinical utility of FDG PET/CT in acute complicated pyelonephritis-results from an observational study. ( 28951990 )
2017
41
Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750A mg/day) or conventional intravenous/oral levofloxacin (500A mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. ( 28108978 )
2017
42
Infectious Pneumorrhachis Due to Emphysematous Pyelonephritis. ( 28873134 )
2017
43
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis. ( 28745629 )
2017
44
Definitions of Complicated Urinary Tract Infection and Pyelonephritis. ( 27986671 )
2017
45
Serial sonographic findings during progression from acute pyelonephritis to renal abscess: a rare case report. ( 28509119 )
2017
46
Emphysematous Pyelonephritis Treated with Vacuum Sealing Drainage. ( 28091422 )
2017
47
Massive Renal Replacement Lipomatosis With Foci of Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney. ( 28443241 )
2017
48
Pyelonephritis with bacteremia caused by Listeria monocytogenes: A case report. ( 27600175 )
2016
49
Pyelonephritis Caused by Salmonella Anatum: An Unusual Case. ( 26982968 )
2016
50
Validity of Neutrophil Gelatinase Associated Lipocaline as a Biomarker for Diagnosis of Children with Acute Pyelonephritis. ( 27734430 )
2016

Variations for Pyelonephritis

Expression for Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for Pyelonephritis

Pathways related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CRP CXCL8 CXCR1 CXCR2 IL10
2
Show member pathways
13.83 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
3
Show member pathways
13.65 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
4
Show member pathways
13.38 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
5
Show member pathways
13.3 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
6
Show member pathways
13 CCL2 CXCL8 IL1B IL6 TLR4 TNF
7
Show member pathways
12.84 CXCL8 IL10 IL1B IL6 TNF
8
Show member pathways
12.84 ACE CCL2 CXCL8 IL10 IL1B IL6
9
Show member pathways
12.83 CCL2 CXCL8 IL1B IL6 TLR4 TNF
10
Show member pathways
12.71 IL1B IL6 PGF TLR4 TNF
11
Show member pathways
12.62 IL10 IL1B IL6 TLR4 TNF
12
Show member pathways
12.62 CCL2 IL10 IL1B IL6 TNF
13 12.52 CCL2 IL10 IL1B TNF
14
Show member pathways
12.42 IL10 IL1B IL6 TNF
15
Show member pathways
12.38 CCL2 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.31 CXCL8 IL1B IL6 TLR4 TNF
17 12.28 IL10 IL1B IL6 TLR4 TNF
18
Show member pathways
12.27 IL10 IL1B TLR4 TNF
19
Show member pathways
12.23 CXCL8 IL1B IL6 TLR4 TNF
20 12.22 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.2 CXCL8 IL10 IL1B IL6 TNF
22
Show member pathways
12.06 CCL2 CXCL8 CXCR1 CXCR2
23 12 CCL2 IL1B IL6 TNF
24
Show member pathways
11.99 IL10 IL1B IL6 TLR4 TNF
25 11.99 CCL2 CXCL8 IL1B IL6 TLR4 TNF
26 11.97 IL10 IL6 TNF
27 11.95 CCL2 CXCL8 IL1B IL6 TNF
28 11.94 CCL2 CXCL8 IL10 IL1B IL6 TNF
29 11.93 CXCL8 IL1B TLR4 TNF
30 11.92 CXCL8 IL1B IL6
31
Show member pathways
11.9 IL1B IL6 TLR4
32 11.89 CXCL8 IL1B IL6 TLR4
33 11.88 IL1B IL6 TNF
34
Show member pathways
11.86 CXCL8 IL6 TLR4
35 11.83 CXCL8 IL10 IL1B IL6 TLR4 TNF
36 11.82 IL10 IL1B IL6 TNF
37 11.78 IL10 IL1B TNF
38 11.78 IL10 IL6 TLR4 TNF
39
Show member pathways
11.72 CXCL8 IL1B IL6 TNF
40 11.69 CCL2 CXCL8 IL1B IL6 TNF
41 11.69 CCL2 CXCL8 IL1B IL6 TLR4 TNF
42 11.62 CXCL8 IL1B IL6 TLR4 TNF
43 11.58 CXCL8 CXCR1 IL6
44 11.58 CCL2 IL1B TLR4 TNF
45 11.52 IL1B IL6 TNF
46 11.51 CXCL8 IL10 IL1B IL6 TLR4 TNF
47 11.42 IL10 IL1B IL6 TNF
48 11.4 ACE CCL2 TLR4
49 11.39 CCL2 CXCL8 IL6
50 11.36 IL1B IL6 TNF

GO Terms for Pyelonephritis

Cellular components related to Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ALB CCL2 CRP CXCL8 IL10
2 external side of plasma membrane GO:0009897 9.46 ACE IL6 TLR4 TNF
3 extracellular region GO:0005576 9.36 ACE ALB CCL2 CRP CXCL8 IL10

Biological processes related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 IL6 TLR4 TNF
2 chemotaxis GO:0006935 9.93 CCL2 CXCL8 CXCR1 CXCR2
3 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TLR4 TNF
5 response to lipopolysaccharide GO:0032496 9.89 CCL2 IL10 IL1B IL6 TLR4
6 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 TNF
7 cellular response to organic cyclic compound GO:0071407 9.87 CCL2 IL1B TNF
8 cellular response to interleukin-1 GO:0071347 9.87 CCL2 CXCL8 IL6
9 positive regulation of JNK cascade GO:0046330 9.86 IL1B TLR4 TNF
10 positive regulation of endothelial cell proliferation GO:0001938 9.85 CCL2 IL10 PGF
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL1B IL6 TNF
12 humoral immune response GO:0006959 9.84 CCL2 IL6 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.81 IL1B TLR4 TNF
14 chemokine-mediated signaling pathway GO:0070098 9.81 CCL2 CXCL8 CXCR1 CXCR2
15 receptor internalization GO:0031623 9.8 CXCL8 CXCR1 CXCR2
16 immune response GO:0006955 9.8 CCL2 CXCL8 IL10 IL1B IL6 TLR4
17 cellular response to estradiol stimulus GO:0071392 9.79 CCL2 IL10 IL6
18 response to glucocorticoid GO:0051384 9.78 CCL2 IL10 IL6 TNF
19 protein kinase B signaling GO:0043491 9.77 CCL2 IL1B TNF
20 response to bacterium GO:0009617 9.76 CCL2 IL6 TLR4
21 neutrophil chemotaxis GO:0030593 9.76 CCL2 CXCL8 CXCR2 IL1B
22 positive regulation of interleukin-8 production GO:0032757 9.74 IL1B TLR4 TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
24 negative regulation of interleukin-6 production GO:0032715 9.73 IL10 TLR4 TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
26 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 IL10 IL6
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
28 induction of positive chemotaxis GO:0050930 9.71 CXCL8 PGF
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR4
30 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR4 TNF
32 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
33 neutrophil mediated immunity GO:0002446 9.7 ACE IL6
34 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
35 neutrophil activation GO:0042119 9.7 CXCL8 CXCR2
36 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR4 TNF
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
38 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 TLR4
40 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
42 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
43 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TLR4 TNF
44 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
45 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
46 regulation of vascular endothelial growth factor production GO:0010574 9.64 CCL2 IL6
47 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B IL6 TLR4 TNF
48 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
50 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B TNF

Molecular functions related to Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
2 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 interleukin-8 receptor activity GO:0004918 8.96 CXCR1 CXCR2

Sources for Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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