MCID: PYL006
MIFTS: 50

Pyloric Stenosis malady

Gastrointestinal diseases category
Download this MalaCard

Summaries for Pyloric Stenosis

About this section


Fully expand this MalaCard
Wikipedia:65 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards based summary: Pyloric Stenosis, also known as acquired stenosis, is related to hirschsprung's disease and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and mptp have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Pyloric Stenosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Pyloric Stenosis, Aliases & Descriptions:

Name: Pyloric Stenosis 8 10 44
 
Acquired Stenosis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:12639
NCIt39 C34966
SNOMED-CT57 367403001
MeSH34 D011707

Related Diseases for Pyloric Stenosis

About this section

Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease30.7GDNF
2hypertrophic pyloric stenosis11.4
3pylorospasm10.6
4esophagitis10.5
5eosinophilic gastroenteritis10.5
6duodenitis10.5
7gastroenteritis10.5
8gastric cancer10.4
9neuronitis10.4
10atrioventricular block10.4NKX2-5
11crohn's disease10.4
12acquired gastric outlet stenosis10.4
13esophageal atresia10.4
14gastric outlet obstruction10.4
15paraganglioma10.3DES
16x-linked ichthyosis10.3
17gilbert syndrome10.3
18pneumatosis cystoides intestinalis10.3
19epidermolysis bullosa10.3
20pertussis10.3
21tracheoesophageal fistula10.3
22epidermolysis bullosa, junctional, with pyloric stenosis10.3
23neonatal jaundice10.3UGT1A1
24duodenal ulcer10.2
25achalasia10.2
26gastric ulcer10.2
27junctional epidermolysis bullosa10.2
28gastric dilatation10.2
29congenital diaphragmatic hernia10.2
30gastritis10.2
31pancreatitis10.2
32gastric duplication cysts10.2
33jejunal atresia10.2
34marden-walker syndrome10.2
35pyloric stenosis, infantile hypertrophic, 310.2
36pyloric stenosis, infantile hypertrophic 110.2
37pyloric stenosis, infantile hypertrophic, 210.2
38pyloric stenosis, infantile hypertrophic, 510.2
39pyloric stenosis, infantile hypertrophic, 410.2
40intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
41brain ischemia10.2GDNF, NOS1
42acoustic neuroma10.1NGFR, GDNF
43diabetic neuropathy10.1GDNF, NGFR
44hemangiopericytoma10.1DES, NGFR
4521-hydroxylase deficiency10.1
46arthritis10.1
47cystic fibrosis10.1
48denys-drash syndrome10.1
49hypertension10.1
50myasthenia gravis10.1

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Symptoms for Pyloric Stenosis

About this section

Drugs & Therapeutics for Pyloric Stenosis

About this section

Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

Genetic Tests for Pyloric Stenosis

About this section

Anatomical Context for Pyloric Stenosis

About this section

MalaCards organs/tissues related to Pyloric Stenosis:

32
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Heart, Liver, Lung, Skin, Ovary, Testes, Endothelial

Animal Models for Pyloric Stenosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6NOS1, HMOX2, NKX2-5, NGFR
2MP:00053818.4GDNF, NGFR, HMOX2, NOS1
3MP:00053768.1NOS1, HMOX2, NKX2-5, NGFR, DES
4MP:00053868.0GDNF, DES, NGFR, HMOX2, NOS1
5MP:00036317.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
6MP:00053697.7NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
7MP:00053857.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1
8MP:00107687.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1

Publications for Pyloric Stenosis

About this section

Articles related to Pyloric Stenosis:

(show top 50)    (show all 719)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
3
Images in clinical medicine. Peristaltic waves in pyloric stenosis. (24088114)
2013
4
Development of pyloric stenosis after a 4-day course of oral erythromycin. (23558266)
2013
5
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
6
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
7
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Proton pump inhibition is a feasible primary alternative to surgery and balloon dilatation in adult peptic pyloric stenosis (APS): report of six consecutive cases. (16551413)
2006
12
Familial pyloric stenosis associated with developmental delays. (15990644)
2005
13
Pyloric stenosis and neuronal nitric oxide synthase]. (15361336)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Junctional epidermolysis bullosa with pyloric stenosis. (11841649)
2001
16
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
17
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
18
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
19
Ectopic pancreas: a rare cause of pyloric stenosis. (10862516)
2000
20
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
21
Erythromycin use linked to pyloric stenosis. (10738394)
2000
22
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
23
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
24
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
25
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
26
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
27
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
28
Congenital pyloric stenosis: a modified umbilical incision for pyloromyotomy (9069247)
1997
29
Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. (8678208)
1996
30
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
31
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
32
Benign pyloric stenosis in an intrathoracic stomach. (7656368)
1995
33
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
34
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
35
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
36
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
37
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
38
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
39
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
40
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
41
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
42
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
43
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
44
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
45
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Pyloric Stenosis

About this section

Expression for genes affiliated with Pyloric Stenosis

About this section
Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for genes affiliated with Pyloric Stenosis

About this section

Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.2HMOX2, UGT1A1
2
Show member pathways
9.0NOS1, NGFR, GDNF
39.0NOS1, NGFR, GDNF

Compounds for genes affiliated with Pyloric Stenosis

About this section

Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin4410.1NOS1, HMOX2
2mptp449.9GDNF, NOS1
3capsaicin44 2810.9GDNF, NOS1
4peroxynitrite449.7NGFR, NOS1
5guanylate449.6NOS1, HMOX2
6hematoxylin449.6DES, NGFR
7imipramine44 28 50 24 1113.6UGT1A1, NOS1
8dbc-amp449.5NGFR, GDNF
9norepinephrine44 24 1111.4GDNF, DES, NOS1
10choline44 24 1111.4NOS1, NGFR, GDNF
11creatinine449.4GDNF, DES, NOS1
12nadph44 2410.4NGFR, HMOX2, NOS1
13gaba449.4NOS1, NGFR, GDNF
14hydroxyurea44 50 1111.3UGT1A1, NOS1
15actinomycin d449.3HMOX2, DES, GDNF
16nmda44 2810.3NOS1, NGFR, GDNF
17iron44 2410.3HMOX2, DES, GDNF
18adenylate449.3NOS1, DES, GDNF
19ibuprofen44 28 50 24 1113.3UGT1A1, NGFR
20ganglioside449.2NGFR, DES, GDNF
21catecholamine449.2GDNF, NGFR
22h2o2449.2GDNF, DES, NOS1
23ethanol44 50 24 1112.2NGFR, DES, GDNF
24genistein44 28 61 2 24 1114.1NOS1, UGT1A1, GDNF
25nicotine44 28 50 1112.1NOS1, NGFR, UGT1A1
26aspartate449.1NOS1, UGT1A1, GDNF
27indomethacin44 28 61 1112.0UGT1A1, NGFR, NOS1
28cyclic amp44 2410.0NGFR, DES, GDNF
29morphine44 50 28 1112.0NOS1, UGT1A1
30dopamine44 28 24 1111.9GDNF, NGFR, HMOX2, NOS1
31superoxide44 249.9NOS1, HMOX2, NGFR, GDNF
32glutamate448.9GDNF, NGFR, HMOX2, NOS1
33testosterone44 61 24 1111.9NOS1, UGT1A1, DES
34vegf448.8GDNF, DES, NGFR, NOS1
35thymidine44 249.8NGFR, UGT1A1, DES
36cysteine448.8GDNF, DES, NGFR, NOS1
37glucose448.7GDNF, DES, NGFR, HMOX2
38arginine448.7DES, UGT1A1, HMOX2, NOS1
39dexamethasone44 50 28 1111.6GDNF, UGT1A1, NGFR, NOS1
40steroid448.5NGFR, UGT1A1, DES
41progesterone44 28 61 24 1112.5DES, UGT1A1, NGFR, HMOX2
42serine448.4GDNF, DES, NGFR, NKX2-5, NOS1
43acetylcholine44 50 28 24 1112.4GDNF, DES, NGFR, HMOX2, NOS1
44oxygen44 249.4GDNF, DES, NGFR, HMOX2, NOS1
45calcium44 50 24 1111.4NOS1, HMOX2, NGFR, DES, GDNF
46retinoic acid44 249.1GDNF, DES, UGT1A1, NGFR, NOS1
47nitric oxide44 24 1110.0NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
48tyrosine448.0GDNF, DES, UGT1A1, NGFR, HMOX2
49estrogen447.6GDNF, DES, UGT1A1, NGFR, HMOX2, NOS1

GO Terms for genes affiliated with Pyloric Stenosis

About this section

Cellular components related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.6NOS1, DES

Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:0551179.7NOS1, NKX2-5
2heme catabolic processGO:0421679.3HMOX2, UGT1A1
3positive regulation of transcription from RNA polymerase II promoterGO:0459449.2NOS1, NKX2-5, GDNF
4porphyrin-containing compound metabolic processGO:0067789.1HMOX2, UGT1A1
5negative regulation of apoptotic processGO:0430668.6GDNF, NGFR, NKX2-5

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.7NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Pyloric Stenosis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Pyloric Stenosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet