MCID: PYL006
MIFTS: 49

Pyloric Stenosis malady

Summaries for Pyloric Stenosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards: Pyloric Stenosis, also known as acquired stenosis, is related to esophagitis and achalasia. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Role of second messengers in netrin-1 signaling and Spinal Cord Injury. The compounds gv 150013 and gsmtx-4 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Pyloric Stenosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

pyloric stenosis 8 10 44
acquired stenosis 60


External Ids:

Disease Ontology8 DOID:12639
MeSH34 D011707
SNOMED-CT56 367403001
NCIt39 C34966

Related Diseases for Pyloric Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis30.7GAST
2achalasia30.2GAST, BLVRB, NOS1
3hirschsprung's disease30.0GDNF
4hypoglycemia30.0MLN, GAST
5cystic fibrosis30.0NGFR
6hypertrophic pyloric stenosis11.4
7pylorospasm10.5
8neuronitis10.4
9eosinophilic gastroenteritis10.4
10duodenitis10.4
11gastroenteritis10.4
12crohn's disease10.3
13esophageal atresia10.3
14acquired gastric outlet stenosis10.3
15gilbert syndrome10.3
16x-linked ichthyosis10.3
17pneumatosis cystoides intestinalis10.3
18epidermolysis bullosa10.3
19pertussis10.3
20epidermolysis bullosa, junctional, with pyloric stenosis10.3
21duodenal ulcer10.2
22epidermolysis bullosa simplex10.2
23junctional epidermolysis bullosa10.2
24gastric dilatation10.2
25tracheal stenosis10.2
26gastric ulcer10.2
27congenital diaphragmatic hernia10.2
28pancreatitis10.2
29pyloric stenosis, infantile hypertrophic, 310.2
30pyloric stenosis, infantile hypertrophic 110.2
31pyloric stenosis, infantile hypertrophic, 210.2
32pyloric stenosis, infantile hypertrophic, 510.2
33pyloric stenosis, infantile hypertrophic, 410.2
34intellectual deficit-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
35acquired tear duct stenosis10.1
3621-hydroxylase deficiency10.0
37vacterl association10.0
38smith-lemli-opitz syndrome10.0
39rothmund-thomson syndrome10.0
40cutis laxa10.0
41renal agenesis10.0
42plexiform schwannoma10.0
43congenital hypothyroidism10.0
44pseudohypoaldosteronism10.0
45hydronephrosis10.0
46systemic lupus erythematosus10.0
47gastroschisis10.0
48sudden infant death syndrome10.0
49arterial tortuosity syndrome10.0
50dyspepsia10.0

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Clinical Features for Pyloric Stenosis

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Drugs & Therapeutics for Pyloric Stenosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pyloric Stenosis

Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

Search CenterWatch for Pyloric Stenosis

Genetic Tests for Pyloric Stenosis

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Anatomical Context for Pyloric Stenosis

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32MalaCards
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MalaCards organs/tissues related to Pyloric Stenosis:

32
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Testes, Ovary, Skin, Heart, Lung, Liver, Endothelial

Animal Models for Pyloric Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.8TRPC1, NGFR, GDNF, HMOX2, NOS1, GAST
2MP:00053699.7NOS1, DES, NKX2-5, TRPC6, NGFR, GDNF
3MP:00053859.3DES, NKX2-5, TRPC1, TRPC6, NGFR, GDNF

Publications for Pyloric Stenosis

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50PubMed
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Articles related to Pyloric Stenosis:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis. (23989729)
2013
2
Bottle-feeding and the Risk of Pyloric Stenosis. (22945411)
2012
3
Bilious vomiting does not rule out infantile hypertrophic pyloric stenosis. (22166750)
2012
4
Evaluation of ultrasonographic parameters in the diagnosis of pyloric stenosis relative to patient age and size. (22901914)
2012
5
Pyloric stenosis--do males and females present differently? (23526330)
2011
6
Open versus laparoscopic pyloromyotomy for pyloric stenosis: a meta-analysis of randomized controlled trials. (20957601)
2011
7
Testosterone levels in umbilical-cord blood and risk of pyloric stenosis. (21172998)
2011
8
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism? (19302103)
2009
9
Pyloric stenosis: role of imaging. (19308372)
2009
10
Return of the surgeon in the diagnosis of pyloric stenosis. (19524738)
2009
11
Pyloric stenosis in an iniencephalic infant with a congenital intra-thoracic stomach. (19727765)
2009
12
Postoperative pyloric stenosis in the newborn: a forgotten problem. (17706505)
2007
13
Idiopathic hypertrophic pyloric stenosis combined with left paraduodenal hernia in an adult. (17303953)
2007
14
Intravenous atropine treatment in hypertrophic pyloric stenosis: evaluation by clinical course and imaging. (17384478)
2007
15
Abnormal oral mucosal light reflectance in infantile hypertrophic pyloric stenosis. (15187781)
2004
16
Infantile hypertrophic pyloric stenosis. (12637675)
2003
17
Treatment of infantile hypertrophic pyloric stenosis in a district general hospital: a review of 160 cases. (14523815)
2003
18
Intravenous atropine treatment in infantile hypertrophic pyloric stenosis. (12089130)
2002
19
Hypertrophic pyloric stenosis in utero. (12415405)
2002
20
Junctional epidermolysis bullosa with pyloric stenosis. (11841649)
2001
21
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
22
Antenatal prediction of hypertrophic pyloric stenosis. (11666061)
2001
23
Successful management of infantile hypertrophic pyloric stenosis with atropine sulfate. (11677299)
2001
24
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
25
Abnormalities of elastin and elastic fibers in infantile hypertrophic pyloric stenosis. (10631728)
1999
26
Lack of response to botulinum toxin A in patients with hypertrophic pyloric stenosis. (10333137)
1999
27
The enigma of pyloric stenosis. Some thoughts on the aetiology. (9116428)
1997
28
Infantile hypertrophic pyloric stenosis and congenital heart disease: an under-recognized association. (9409170)
1997
29
Pyloric stenosis in the age of ultrasonography: fading skills, better patients? (8783115)
1996
30
Pyloric stenosis in premature infants. (8556133)
1996
31
Benign pyloric stenosis in an intrathoracic stomach. (7656368)
1995
32
Trophic effects in the acid-producing part of the rat stomach after pyloric stenosis. (9053966)
1995
33
Hypertrophic pyloric stenosis: volumetric measurement of nasogastric aspirate to determine imaging modality. (2028013)
1991
34
Hypertrophic pyloric stenosis: volumetric measurement of nasogastric aspirate to determine the imaging modality. (2243984)
1990
35
Balloon catheter dilatation for hypertrophic pyloric stenosis. (2273424)
1990
36
Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. (2914260)
1989
37
Myenteric plexus neuropathy in infantile hypertrophic pyloric stenosis. (2816307)
1989
38
Hypertrophic pyloric stenosis, ultrasonic appearances in a small baby. (3174282)
1988
39
Anaesthesia for congenital hypertrophic pyloric stenosis. A review of 350 patients. (3606911)
1987
40
Ultrasonic "double track" sign in hypertrophic pyloric stenosis. (3550137)
1987
41
Sonography of the normal and abnormal stomach (excluding hypertrophic pyloric stenosis in children. (3514946)
1986
42
Peptidergic innervation in infantile hypertrophic pyloric stenosis. (2422340)
1986
43
Clinical observation of infantile hypertrophic pyloric stenosis in Chinese. (3868702)
1985
44
Infantile hypertrophic pyloric stenosis in Greater Manchester. (6886586)
1983
45
Adult hypertrophic pyloric stenosis--a description in 1834? (6350566)
1983
46
Infantile hypertrophic pyloric stenosis: a review. (7039756)
1982
47
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
48
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979
49
Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test. (434907)
1979
50
Congenital pyloric stenosis together with reports of two cases of duodenal and one case of jejunal atresia. (15402480)
1950

Genetic Variations for Pyloric Stenosis

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Expression for genes affiliated with Pyloric Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

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Pathways for genes affiliated with Pyloric Stenosis

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TRPC6, TRPC1
210.2NOS1, GDNF, NGFR
3
Hide members
10.1UGT1A1, BLVRB, HMOX2
4
Hide members
10.1HMOX2, BLVRB, UGT1A1

Compounds for genes affiliated with Pyloric Stenosis

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44Novoseek, 28IUPHAR, 24HMDB, 2BitterDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1gv 1500134410.6GAST, NOS1
2gsmtx-42810.6TRPC6, TRPC1
3trimebutine4410.5GAST, MLN
4hematoxylin4410.5BLVRB, DES, S100B
5orcein4410.5DES, S100B
6skf 963654410.5TRPC6, TRPC1
7ng-nitro-l-arginine4410.5GAST, BLVRB, NOS1
8lafutidine4410.5MLN, GAST
9catecholamine4410.4S100B, BLVRB, GDNF, NGFR
10skf963652810.4TRPC1, TRPC6
11biliverdin44 2411.4HMOX2, BLVRB
12acetaminophen44 2 49 11 2414.4UGT1A1
13nicotine44 49 28 1113.4GAST, NOS1, NGFR, UGT1A1
14choline44 11 2412.4S100B, BLVRB, NGFR, GDNF, NOS1
15capsaicin44 2811.4GDNF, TRPC1, NOS1
16bromodeoxyuridine4410.3GDNF, GAST, S100B, DES
17formaldehyde44 2411.3NOS1, DES, BLVRB, TYMP, S100B
18indomethacin44 59 28 1113.3UGT1A1, NOS1, BLVRB, TYMP, NGFR
19s 1004410.3S100B, DES
20atropine44 28 1112.3GAST, MLN, NOS1
21ethanol44 49 11 2413.3BLVRB, GDNF, DES, S100B, NGFR
22norepinephrine44 11 2412.3NOS1, DES, GAST, S100B, GDNF
23nadph44 2411.3NGFR, S100B, BLVRB, HMOX2, NOS1
24ganglioside4410.3NGFR, DES, GDNF
25paraffin4410.2TYMP, BLVRB, DES, S100B, NGFR
26gaba4410.2NGFR, GAST, S100B, GDNF, NOS1, BLVRB
27superoxide44 2411.2NOS1, HMOX2, GDNF, BLVRB, NGFR
28iron44 2411.2GDNF, HMOX2, BLVRB, DES, S100B
29thymidine44 2411.2TYMP, GAST, NGFR, S100B, DES, UGT1A1
30creatinine4410.2NOS1, GAST, S100B, DES, TYMP, GDNF
31bethanechol44 28 1112.2MLN, GAST
32dexamethasone44 49 28 1113.2GAST, S100B, NOS1, GDNF, NGFR, UGT1A1
33testosterone44 59 11 2413.1DES, S100B, NOS1, BLVRB, UGT1A1, GAST
34vegf4410.1TYMP, GDNF, NGFR, S100B, GAST, DES
35glutamate4410.1HMOX2, GAST, BLVRB, NGFR, GDNF, NOS1
36arginine4410.1MLN, UGT1A1, S100B, HMOX2, BLVRB, DES
37dbc-amp4410.1S100B, GDNF, NGFR
38adenylate4410.0S100B, NOS1, GDNF, BLVRB, DES, MLN
39oxygen44 2411.0TYMP, DES, NOS1, HMOX2, GDNF, NGFR
40alanine4410.0GAST, MLN, GDNF, NOS1, UGT1A1, S100B
41heparin44 28 11 2413.0GAST, MLN, GDNF, DES, S100B
42progesterone44 59 28 11 2414.0BLVRB, DES, UGT1A1, MLN, TYMP, NGFR
43dopamine44 28 11 2413.0BLVRB, NOS1, NGFR, MLN, GAST, S100B
44gd3+289.9TRPC1, TRPC6
45acetylcholine44 49 28 11 2413.9NOS1, HMOX2, GDNF, NGFR, BLVRB, DES
46serine449.9GDNF, NGFR, NOS1, MLN, TYMP, NKX2-5
47glucose449.8GAST, NGFR, GDNF, HMOX2, TYMP, MLN
48tyrosine449.7HMOX2, NGFR, TYMP, BLVRB, DES, MLN
49nitric oxide44 11 2411.6NGFR, NOS1, S100B, HMOX2, GDNF, TYMP
50calcium44 49 11 2412.6GAST, HMOX2, GDNF, NGFR, BLVRB, TRPC6

GO Terms for genes affiliated with Pyloric Stenosis

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16Gene Ontology
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Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:04216710.1HMOX2, BLVRB, UGT1A1
2porphyrin-containing compound metabolic processGO:00677810.0HMOX2, BLVRB, UGT1A1
3regulation of cardiac muscle contractionGO:05511710.0NKX2-5, NOS1
4axon guidanceGO:00741110.0GDNF, NGFR, TRPC6, TRPC1

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:01527910.2TRPC6, TRPC1
2inositol 1,4,5 trisphosphate bindingGO:0706799.9TRPC6, TRPC1

Products for genes affiliated with Pyloric Stenosis

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Sources for Pyloric Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet