MCID: PYL006
MIFTS: 46

Pyloric Stenosis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Pyloric Stenosis

Aliases & Descriptions for Pyloric Stenosis:

Name: Pyloric Stenosis 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12639
ICD10 33 K31.1
MeSH 42 D011707
NCIt 47 C34966
SNOMED-CT 64 367403001
UMLS 69 C0034194

Summaries for Pyloric Stenosis

MalaCards based summary : Pyloric Stenosis is related to hiatus hernia and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Neuroscience and Signaling events regulated by Ret tyrosine kinase. The drugs Aspirin and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 71 Pyloric stenosis is a narrowing of the opening from the stomach to the first part of the small intestine... more...

Related Diseases for Pyloric Stenosis

Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 hiatus hernia 27.7 DMD HMOX2 MBNL1 NKX2-5 NOS1 NTF4
2 hypertrophic pyloric stenosis 12.6
3 pyloric stenosis, infantile hypertrophic, 5 12.0
4 pyloric stenosis, infantile hypertrophic, 4 12.0
5 pyloric stenosis, infantile hypertrophic, 3 12.0
6 pyloric stenosis, infantile hypertrophic, 2 12.0
7 epidermolysis bullosa, junctional, with pyloric stenosis 11.9
8 intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome 11.9
9 acquired gastric outlet stenosis 11.5
10 autoimmune gastrointestinal dysmotility 11.0
11 esophagitis 10.2
12 ascariasis 10.2 NTRK3 SST
13 pylorospasm 10.2
14 meigel disease 10.1 GDNF RET
15 prosthetic joint infection 10.1 DMD NOS1
16 early-onset parkinson disease 10.1 RET SST
17 hypoparathyroidism-intellectual disability-dysmorphism syndrome 10.1 GDNF RET
18 esophageal atresia 10.0
19 duodenitis 10.0
20 eosinophilic gastroenteritis 10.0
21 gastroenteritis 10.0
22 neuronitis 10.0
23 psychosexual disorder 10.0 GDNF NOS1
24 sweat gland cancer 10.0 GDNF RET SST
25 gastric cancer 10.0
26 neutropenia, severe congenital, 5, autosomal recessive 10.0 GDNF RET SST
27 cardiomyopathy, familial restrictive, 3 10.0 DMD HMOX2
28 tracheoesophageal fistula 9.9
29 crohn's disease 9.9
30 epidermolysis bullosa 9.9
31 mucositis 9.9
32 hirschsprung disease 1 9.9 GDNF RET
33 pheochromocytoma 9.9 GDNF RET SST
34 gastric dilatation 9.9
35 pertussis 9.9
36 ichthyosis 9.9
37 pancreatitis 9.9
38 pneumatosis cystoides intestinalis 9.9
39 gilbert syndrome 9.9
40 ariboflavinosis 9.8 GDNF HDC RET
41 gastric ulcer 9.8
42 junctional epidermolysis bullosa 9.8
43 jejunal atresia 9.8
44 congenital diaphragmatic hernia 9.8
45 heart disease 9.8
46 gastritis 9.8
47 duodenal ulcer 9.8
48 achalasia 9.8
49 adenomyoma 9.8
50 gastroesophageal reflux 9.8

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to Pyloric Stenosis

Symptoms & Phenotypes for Pyloric Stenosis

MGI Mouse Phenotypes related to Pyloric Stenosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 DMD GDNF HDC HMOX2 MBNL1 NOS1
2 cardiovascular system MP:0005385 10.11 DMD GDNF HMOX2 MBNL1 NKX2-5 NOS1
3 growth/size/body region MP:0005378 10.1 DMD GDNF HDC MBNL1 NKX2-5 NOS1
4 homeostasis/metabolism MP:0005376 10.02 DMD HDC HMOX2 NKX2-5 NOS1 NTF4
5 mortality/aging MP:0010768 10.02 HMOX2 MBNL1 NKX2-5 NOS1 NTF4 NTRK3
6 digestive/alimentary MP:0005381 9.98 DMD GDNF HMOX2 NKX2-5 NOS1 RET
7 nervous system MP:0003631 9.97 TRPC6 DMD GDNF HDC HMOX2 MBNL1
8 muscle MP:0005369 9.86 DMD GDNF HMOX2 MBNL1 NKX2-5 NOS1
9 no phenotypic analysis MP:0003012 9.56 DMD HDC NKX2-5 NOS1 NTRK3 RET
10 respiratory system MP:0005388 9.1 DMD HMOX2 NKX2-5 NOS1 NTRK3 RET

Drugs & Therapeutics for Pyloric Stenosis

Drugs for Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
3
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
4
Ibuprofen Approved Phase 3 15687-27-1 3672
5
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
6
Famotidine Approved Phase 3 76824-35-6 3325
7
Naproxen Approved, Vet_approved Phase 3 22204-53-1 1302 156391
8
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
9
Meperidine Approved Phase 3 57-42-1 4058
10
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
11
Ticlopidine Approved Phase 3 55142-85-3 5472
12
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
13
Dexlansoprazole Phase 3 138530-94-6, 103577-45-3 9578005
14
Histamine Phosphate Phase 3 51-74-1 65513
15
Proton pump inhibitors Phase 3
16 Analgesics Phase 3
17 Gastrointestinal Agents Phase 3
18 Neurotransmitter Agents Phase 3
19 Cyclooxygenase 2 Inhibitors Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Analgesics, Non-Narcotic Phase 3
22 Histamine Antagonists Phase 3
23 Histamine H2 Antagonists Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Antacids Phase 3
26 Platelet Aggregation Inhibitors Phase 3
27 Fibrinolytic Agents Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30 Anti-Ulcer Agents Phase 3
31 Antipyretics Phase 3
32 Antirheumatic Agents Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3
34 Purinergic P2 Receptor Antagonists Phase 3
35 Purinergic P2Y Receptor Antagonists Phase 3
36
Acetaminophen Approved 103-90-2 1983
37
Epinephrine Approved, Vet_approved 51-43-4 5816
38
Rocuronium Approved 119302-91-9, 143558-00-3 441290
39
Sevoflurane Approved, Vet_approved 28523-86-6 5206
40
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
41
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
42
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7 4594 9579578
43
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
44
Methylene blue Investigational 61-73-4
45 mosapride 112885-41-3
46 Chelating Agents
47
Serotonin 50-67-9 5202
48 Serotonin Agents
49 Hemostatics
50 Anesthetics

Interventional clinical trials:

(show all 32)
id Name Status NCT ID Phase
1 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
2 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
3 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Unknown status NCT00753441 Phase 2, Phase 3
4 Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis Completed NCT00195949 Phase 3
5 Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction Completed NCT01646476 Phase 3
6 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3
7 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3
8 Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy Recruiting NCT02784470 Phase 3
9 Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer Recruiting NCT02064803 Phase 3
10 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3
11 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
12 Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction Terminated NCT00487552 Phase 1
13 Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis Unknown status NCT00409734
14 The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood Unknown status NCT01159509
15 The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents Unknown status NCT02440724
16 Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis Unknown status NCT00144924
17 Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis Completed NCT01139853 Early Phase 1
18 Gastric Outlet Obstructions Tailored Covered Stents for GOO Completed NCT02299258
19 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
20 ComVi and D-type Stent in Malignant GOO Completed NCT01839292
21 Different Feeding Methods After Pyloromyotomy Completed NCT01509417
22 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
23 Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation (IRE) System Recruiting NCT02041936
24 Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance. Recruiting NCT02562157
25 Biliary Drainage in Patients With Duodenal Metal Stent Active, not recruiting NCT02376907
26 Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy Enrolling by invitation NCT02775214
27 Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy Enrolling by invitation NCT02359305
28 Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis Enrolling by invitation NCT02564965
29 Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia Not yet recruiting NCT02879292
30 Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study Not yet recruiting NCT03095144
31 Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China Not yet recruiting NCT03040817
32 Endoscopic Sleeve Gastroplasty for Morbid Obesity Not yet recruiting NCT03124485

Search NIH Clinical Center for Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis

Genetic Tests for Pyloric Stenosis

Genetic tests related to Pyloric Stenosis:

id Genetic test Affiliating Genes
1 Pyloric Stenosis 29

Anatomical Context for Pyloric Stenosis

MalaCards organs/tissues related to Pyloric Stenosis:

39
Small Intestine, Pancreas, Breast, Smooth Muscle, Heart, Kidney, Testes

Publications for Pyloric Stenosis

Articles related to Pyloric Stenosis:

(show top 50) (show all 795)
id Title Authors Year
1
Recent changes in the features of hypertrophic pyloric stenosis. ( 26615824 )
2016
2
Pitfall in the remote imaging of pyloric stenosis. ( 27260853 )
2016
3
Health disparities in infants with hypertrophic pyloric stenosis. ( 27586849 )
2016
4
Treating idiopathic hypertrophic pyloric stenosis with sequential therapy: A clinical study. ( 27439633 )
2016
5
Recurrent pyloric stenosis. ( 27389044 )
2016
6
Optimizing fluid resuscitation in hypertrophic pyloric stenosis. ( 26876090 )
2016
7
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )
2016
8
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
9
Ultrasound assessment of the gastric contents for the guidance of the anaesthetic strategy in infants with hypertrophic pyloric stenosis: a prospective cohort study. ( 27106968 )
2016
10
Cost of Hospitalization for Infantile Pyloric Stenosis. ( 26802838 )
2016
11
Successful combination of endoscopic pyloromyotomy and balloon dilatation for hypertrophic pyloric stenosis in an older child: A novel procedure. ( 27915443 )
2016
12
Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 27655365 )
2016
13
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. ( 26944185 )
2016
14
Prematurity Affects Age of Presentation of Pyloric Stenosis. ( 27149987 )
2016
15
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )
2016
16
No association between macrolide treatment in infancy and later pyloric stenosis in Sweden. ( 26694588 )
2016
17
Contemporary management of pyloric stenosis. ( 27521712 )
2016
18
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )
2016
19
Roux-en-Y augmented gastric advancement: An alternative technique for concurrent esophageal and pyloric stenosis secondary to corrosive intake. ( 28070231 )
2016
20
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )
2016
21
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. ( 27292596 )
2016
22
Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. ( 27506212 )
2016
23
Asymmetric Hypertrophic Pyloric Stenosis with Concurrent Pancreatic Rest Presenting as Gastric Outlet Obstruction. ( 27179550 )
2016
24
The cervix sign and other sonographic signs of hypertrophic pyloric stenosis. ( 27315074 )
2016
25
Adult idiopathic hypertrophic pyloric stenosis. ( 27362602 )
2016
26
Gastric wall ischemia following massive gastric distension due to peptic pyloric stenosis: a case report. ( 26851051 )
2016
27
Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. ( 27528563 )
2016
28
NSAID-induced pyloric stenosis leading to oesophageal intramucosal dissection. ( 27199442 )
2016
29
A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. ( 27829521 )
2016
30
Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? ( 27251656 )
2016
31
A novel missense mutation in the transcription factor FOXF1 co-segregating with infantile hypertrophic pyloric stenosis in the extended pedigree linked to IHPS5 on chromosome 16q24. ( 27855150 )
2016
32
Risk factors and management for pyloric stenosis occurred after endoscopic submucosal dissection adjacent to pylorus. ( 27977608 )
2016
33
Azithromycin: pyloric stenosis in neonates. ( 27486645 )
2016
34
The use of ultrasonography in infantile hypertrophic pyloric stenosis: does the patient's age and weight affect pyloric size and pyloric ratio? ( 25745654 )
2015
35
Pyloric stenosis-postoperative care on a nonsurgical ward. ( 25972312 )
2015
36
Recurrent Pyloric Stenosis: A Rare Entity. ( 26601744 )
2015
37
Birth outcomes of male and female patients with infantile hypertrophic pyloric stenosis - a population-based case-control study. ( 26135791 )
2015
38
One hundred years of pyloric stenosis in the Royal Hospital for Sick Children Edinburgh. ( 25638619 )
2015
39
Endoscopic pyloromyotomy for congenital pyloric stenosis. ( 26385284 )
2015
40
The cause of pyloric stenosis of infancy: A hyperacidity pathogenesis. ( 26654484 )
2015
41
Brain oxygenation during laparoscopic correction of hypertrophic pyloric stenosis. ( 25768674 )
2015
42
How to best induce anesthesia in infants with pyloric stenosis? ( 26053769 )
2015
43
Pneumatosis intestinalis presenting as pneumoperitoneum in a teenage girl with pyloric stenosis. ( 25721833 )
2015
44
Pyloric stenosis after a Roux-en-Y gastric bypass: a case report. ( 25541110 )
2015
45
Peroral endoscopic pyloromyotomy for primary pyloric stenosis. ( 26714160 )
2015
46
Incidence and Concurrent Laparoscopic Repair of Hypertrophic Pyloric Stenosis and Patent Processus Vaginalis. ( 25836622 )
2015
47
Post-Operative Impact of Nasogastric Tubes on length of stay in infants with pyloric Stenosis (POINTS): A prospective randomized controlled pilot trial. ( 25783381 )
2015
48
Aspiration risk in pyloric stenosis. ( 26214298 )
2015
49
50 years ago in The Journal of Pediatrics: congenital pyloric stenosis: a controlled evaluation of medical treatment utilizing methyl-scopolamine-nitrate. ( 25722265 )
2015
50
Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. ( 26581339 )
2015

Variations for Pyloric Stenosis

Expression for Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for Pyloric Stenosis

Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 NOS1 NTRK3 RET TRPC6
2 10.84 GDNF RET
3 10.55 TRPC5 TRPC6
4 10.23 DMD NOS1

GO Terms for Pyloric Stenosis

Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 DMD NOS1 RET TRPC5

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.84 GDNF NKX2-5 NTRK3 TRPC5
2 neuron differentiation GO:0030182 9.63 RET TRPC5 TRPC6
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.61 NTF4 NTRK3 RET
4 regulation of cytosolic calcium ion concentration GO:0051480 9.55 TRPC5 TRPC6
5 nervous system development GO:0007399 9.55 GDNF MBNL1 NTRK3 RET TRPC5
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.52 TRPC5 TRPC6
7 neural crest cell migration GO:0001755 9.51 GDNF RET
8 regulation of cardiac muscle contraction GO:0055117 9.49 NKX2-5 NOS1
9 innervation GO:0060384 9.48 NTF4 RET
10 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.4 DMD NOS1
11 manganese ion transport GO:0006828 9.37 TRPC5 TRPC6
12 enteric nervous system development GO:0048484 9.32 GDNF RET
13 negative regulation of dendrite morphogenesis GO:0050774 9.26 TRPC5 TRPC6
14 mechanoreceptor differentiation GO:0042490 8.96 NTF4 NTRK3
15 positive regulation of neuron differentiation GO:0045666 8.92 DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 store-operated calcium channel activity GO:0015279 9.16 TRPC5 TRPC6
2 actinin binding GO:0042805 8.96 TRPC5 TRPC6
3 inositol 1,4,5 trisphosphate binding GO:0070679 8.62 TRPC5 TRPC6
4 protein binding GO:0005515 10.03 DMD GDNF HDC HMOX2 MBNL1 NKX2-5

Sources for Pyloric Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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