MCID: PYL006
MIFTS: 47

Pyloric Stenosis

Categories: Gastrointestinal diseases

Aliases & Classifications for Pyloric Stenosis

MalaCards integrated aliases for Pyloric Stenosis:

Name: Pyloric Stenosis 12 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12639
ICD10 32 K31.1
MeSH 41 D011707
NCIt 46 C34966
SNOMED-CT 64 367403001
UMLS 69 C0034194

Summaries for Pyloric Stenosis

MalaCards based summary : Pyloric Stenosis is related to hypertrophic pyloric stenosis and hirschsprung disease 1. An important gene associated with Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Neuroscience and Signaling events regulated by Ret tyrosine kinase. The drugs Midazolam and Famotidine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 Pyloric stenosis is a narrowing of the opening from the stomach to the first part of the small intestine... more...

Related Diseases for Pyloric Stenosis

Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 hypertrophic pyloric stenosis 30.4 DMD FOXF1 MBNL1 NKX2-5 NOS1 NTF4
2 hirschsprung disease 1 29.3 GDNF NOS1 NTRK3 RET
3 pyloric stenosis, infantile hypertrophic, 1 12.6
4 pyloric stenosis, infantile hypertrophic, 5 12.3
5 pyloric stenosis, infantile hypertrophic, 4 12.1
6 pyloric stenosis, infantile hypertrophic, 2 12.1
7 pyloric stenosis, infantile hypertrophic, 3 12.1
8 intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome 12.0
9 acquired gastric outlet stenosis 11.8
10 duodenal atresia 11.1
11 congenital generalized lipodystrophy 11.1
12 epidermolysis bullosa junctionalis with pyloric atresia 11.1
13 esophagitis 10.3
14 type c thymoma 10.2 NTRK3 SST
15 aging 10.2
16 pylorospasm 10.2
17 medullary sponge kidney 10.2 GDNF RET
18 ectopic cushing syndrome 10.2 RET SST
19 hypoganglionosis 10.2 GDNF RET
20 jejunoileitis 10.1 GDNF NOS1
21 multiple endocrine neoplasia, type iib 10.1 GDNF RET
22 tracheoesophageal fistula with or without esophageal atresia 10.1
23 esophageal atresia 10.1
24 gastroenteritis 10.1
25 eosinophilic gastroenteritis 10.1
26 neuronitis 10.1
27 duodenitis 10.1
28 gastric cancer 10.1
29 muscular dystrophy, becker type 10.1 DMD NOS1
30 crohn's disease 10.0
31 mucositis 10.0
32 epidermolysis bullosa 10.0
33 streptococcal group a invasive disease 10.0
34 tracheoesophageal fistula 10.0
35 colonic disease 10.0 GDNF RET
36 gilbert syndrome 10.0
37 ichthyosis, x-linked 10.0
38 pertussis 10.0
39 heart disease 10.0
40 pneumatosis cystoides intestinalis 10.0
41 ichthyosis 10.0
42 gastric dilatation 10.0
43 pancreatitis 10.0
44 goldberg-shprintzen syndrome 9.9 GDNF RET
45 constipation 9.9 GDNF RET SST
46 thyroid carcinoma, familial medullary 9.9 GDNF RET SST
47 gastroesophageal reflux 9.9
48 diaphragmatic hernia, congenital 9.9
49 jejunal atresia 9.9
50 myasthenia gravis 9.9

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to Pyloric Stenosis

Symptoms & Phenotypes for Pyloric Stenosis

MGI Mouse Phenotypes related to Pyloric Stenosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.2 DMD GDNF HDC MBNL1 NOS1 NTF4
2 cardiovascular system MP:0005385 10.09 DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
3 growth/size/body region MP:0005378 10.07 DMD NTRK3 RET SST GDNF HDC
4 mortality/aging MP:0010768 10.02 DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
5 digestive/alimentary MP:0005381 9.95 DMD FOXF1 GDNF NKX2-5 NOS1 RET
6 nervous system MP:0003631 9.93 NTF4 NTRK3 RET SST TRPC5 TRPC6
7 muscle MP:0005369 9.86 MBNL1 NKX2-5 NOS1 RET TRPC6 DMD
8 no phenotypic analysis MP:0003012 9.56 DMD HDC NKX2-5 NOS1 NTRK3 RET
9 respiratory system MP:0005388 9.1 DMD FOXF1 NKX2-5 NOS1 NTRK3 RET

Drugs & Therapeutics for Pyloric Stenosis

Drugs for Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
2
Famotidine Approved Phase 3 76824-35-6 3325
3
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
4
Ibuprofen Approved Phase 3 15687-27-1 3672
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
7
Dexlansoprazole Approved, Investigational Phase 3 138530-94-6, 103577-45-3 9578005
8
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
9
Naproxen Approved, Vet_approved Phase 3 22204-53-1 156391 1302
10
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
11
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
12
Ticlopidine Approved Phase 3 55142-85-3 5472
13 Analgesics Phase 3
14 Analgesics, Non-Narcotic Phase 3
15 Antacids Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antirheumatic Agents Phase 3
19 Anti-Ulcer Agents Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Gastrointestinal Agents Phase 3
22 Histamine Antagonists Phase 3
23 Histamine H2 Antagonists Phase 3
24
Histamine Phosphate Phase 3 51-74-1 65513
25 Neurotransmitter Agents Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Antipyretics Phase 3
28 Cyclooxygenase 2 Inhibitors Phase 3
29 Fibrinolytic Agents Phase 3
30 Platelet Aggregation Inhibitors Phase 3
31 Proton pump inhibitors Phase 3
32 Anesthetics Phase 2, Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3
34 Purinergic P2 Receptor Antagonists Phase 3
35 Purinergic P2Y Receptor Antagonists Phase 3
36
Acetaminophen Approved 103-90-2 1983
37
Azithromycin Approved 83905-01-5 53477736 447043 55185
38
Cefazolin Approved 25953-19-9 33255 656510
39
Clindamycin Approved, Vet_approved 18323-44-9 29029
40
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7 9579578 4594
41
Methylene blue Approved, Investigational 61-73-4
42
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
43
Epinephrine Approved, Vet_approved 51-43-4 5816
44
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
45
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
46 Racepinephrine Approved 329-65-7
47
Rocuronium Approved 119302-91-9, 143558-00-3 441290
48
Sevoflurane Approved, Vet_approved 28523-86-6 5206
49
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
50 Mosapride Investigational 112885-41-3

Interventional clinical trials:

(show all 34)

# Name Status NCT ID Phase Drugs
1 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
2 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
3 Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis Completed NCT00195949 Phase 3
4 Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction Completed NCT01646476 Phase 3
5 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3 Ibuprofen/famotidine;Ibuprofen
6 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3 Lansoprazole and naproxen and aspirin;Celecoxib and aspirin
7 Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy Recruiting NCT02784470 Phase 3
8 Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer Recruiting NCT02064803 Phase 3
9 Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial. Not yet recruiting NCT03223831 Phase 3
10 EUS - Guided Balloon-occluded Gastrojejunostomy Bypass Not yet recruiting NCT03223480 Phase 2, Phase 3
11 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
12 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
13 Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis Unknown status NCT00409734
14 The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents Unknown status NCT02440724
15 The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood Unknown status NCT01159509
16 Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis Unknown status NCT00144924
17 Biliary Drainage in Patients With Duodenal Metal Stent Unknown status NCT02376907
18 Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis Completed NCT01139853 Early Phase 1
19 Gastric Outlet Obstructions Tailored Covered Stents for GOO Completed NCT02299258
20 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
21 ComVi and D-type Stent in Malignant GOO Completed NCT01839292
22 Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy Completed NCT02359305 Acetaminophen;Acetaminophen
23 Different Feeding Methods After Pyloromyotomy Completed NCT01509417
24 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Azithromycin and standard of care;Placebo and standard of care
25 Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China Recruiting NCT03040817 Esomeprazole + Mosapride
26 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
27 Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation (IRE) System Recruiting NCT02041936
28 Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy Enrolling by invitation NCT02775214
29 Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis Enrolling by invitation NCT02564965
30 EUS-GE vs ES for Palliation of GOO Not yet recruiting NCT03259763
31 Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia Not yet recruiting NCT02879292
32 Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study Not yet recruiting NCT03095144
33 Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction Terminated NCT00487552
34 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Terminated NCT00753441

Search NIH Clinical Center for Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis

Genetic Tests for Pyloric Stenosis

Genetic tests related to Pyloric Stenosis:

# Genetic test Affiliating Genes
1 Pyloric Stenosis 28

Anatomical Context for Pyloric Stenosis

MalaCards organs/tissues related to Pyloric Stenosis:

38
Small Intestine, Pancreas, Heart, Kidney, Smooth Muscle, Testes, Cervix

Publications for Pyloric Stenosis

Articles related to Pyloric Stenosis:

(show top 50) (show all 817)
# Title Authors Year
1
Pyloric stenosis: an enigma more than a century after the first successful treatment. ( 29030700 )
2018
2
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a survey of 407 children. ( 29411105 )
2018
3
Current perioperative care of infants with pyloric stenosis: comparison of survey results. ( 29157882 )
2018
4
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
5
Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon. ( 29338765 )
2018
6
Excessive Bright Echoes Sign for Hypertrophic Pyloric Stenosis Suggest the Diagnosis: Gastric Pneumatosis and Portal Venous Gas in Infants Suggest HPS. ( 28295432 )
2017
7
Application of color Doppler ultrasound combined with Doppler imaging artifacts in the diagnosis and estimate of congenital hypertrophic pyloric stenosis. ( 28842652 )
2017
8
Transient neonatal myasthenia gravis with infantile hypertrophic pyloric stenosis: coincidence or causation? ( 29099348 )
2017
9
Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. ( 28318599 )
2017
10
The treatment of pyloric stenosis: Evolution in practice. ( 29148193 )
2017
11
Population-level surgical outcomes for infantile hypertrophic pyloric stenosis. ( 28576429 )
2017
12
A Difficult Recurrent Hypertrophic Pyloric Stenosis. ( 28770145 )
2017
13
Atropine Treatment for Hypertrophic Pyloric Stenosis: A Systematic Review and Meta-analysis. ( 28701002 )
2017
14
Consideration of pyloric stenosis as a cause of feeding dysfunction in children with cyanotic heart disease. ( 28928620 )
2017
15
Use of a lumen-apposing metal stent to treat pyloric stenosis. ( 28389214 )
2017
16
Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis? ( 28550912 )
2017
17
Corrected to uncorrected? The metabolic conundrum of hypertrophic pyloric stenosis. ( 28189444 )
2017
18
Epidemiological and clinical characteristics of 304 patients with infantile hypertrophic pyloric stenosis in Anhui Province of East China, 2012-2015. ( 28701060 )
2017
19
Caterpillar Sign in Infantile Hypertrophic Pyloric Stenosis. ( 29236645 )
2017
20
A breathtakingly rare presentation of pyloric stenosis. ( 28665094 )
2017
21
50 Years Ago in The Journal of Pediatrics: The Radiographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis. ( 28648281 )
2017
22
Contemporary management of pyloric stenosis. ( 27521712 )
2016
23
Risk factors and management for pyloric stenosis occurred after endoscopic submucosal dissection adjacent to pylorus. ( 27977608 )
2016
24
Health disparities in infants with hypertrophic pyloric stenosis. ( 27586849 )
2016
25
Recurrent pyloric stenosis. ( 27389044 )
2016
26
Ultrasound assessment of the gastric contents for the guidance of the anaesthetic strategy in infants with hypertrophic pyloric stenosis: a prospective cohort study. ( 27106968 )
2016
27
Pitfall in the remote imaging of pyloric stenosis. ( 27260853 )
2016
28
Prematurity Affects Age of Presentation of Pyloric Stenosis. ( 27149987 )
2016
29
Gastric wall ischemia following massive gastric distension due to peptic pyloric stenosis: a case report. ( 26851051 )
2016
30
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )
2016
31
NSAID-induced pyloric stenosis leading to oesophageal intramucosal dissection. ( 27199442 )
2016
32
Cost of Hospitalization for Infantile Pyloric Stenosis. ( 26802838 )
2016
33
Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. ( 27528563 )
2016
34
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )
2016
35
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )
2016
36
Recent changes in the features of hypertrophic pyloric stenosis. ( 26615824 )
2016
37
Idiopathic pyloric stenosis. ( 28154715 )
2016
38
Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 27655365 )
2016
39
The cervix sign and other sonographic signs of hypertrophic pyloric stenosis. ( 27315074 )
2016
40
Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? ( 27251656 )
2016
41
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. ( 26944185 )
2016
42
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
43
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. ( 27292596 )
2016
44
Successful combination of endoscopic pyloromyotomy and balloon dilatation for hypertrophic pyloric stenosis in an older child: A novel procedure. ( 27915443 )
2016
45
Roux-en-Y augmented gastric advancement: An alternative technique for concurrent esophageal and pyloric stenosis secondary to corrosive intake. ( 28070231 )
2016
46
No association between macrolide treatment in infancy and later pyloric stenosis in Sweden. ( 26694588 )
2016
47
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )
2016
48
A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. ( 27829521 )
2016
49
Asymmetric Hypertrophic Pyloric Stenosis with Concurrent Pancreatic Rest Presenting as Gastric Outlet Obstruction. ( 27179550 )
2016
50
Optimizing fluid resuscitation in hypertrophic pyloric stenosis. ( 26876090 )
2016

Variations for Pyloric Stenosis

Expression for Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for Pyloric Stenosis

Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 NOS1 NTRK3 RET TRPC6
2 10.84 GDNF RET
3 10.55 TRPC5 TRPC6
4 10.23 DMD NOS1

GO Terms for Pyloric Stenosis

Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.26 DMD RET SST TRPC5
2 membrane raft GO:0045121 8.92 DMD NOS1 RET TRPC5

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.72 FOXF1 NTRK3 RET
2 nervous system development GO:0007399 9.72 GDNF MBNL1 NTRK3 RET TRPC5
3 positive regulation of cell proliferation GO:0008284 9.65 DMD GDNF NKX2-5 NTRK3 TRPC5
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.63 NTF4 NTRK3 RET
5 regulation of cytosolic calcium ion concentration GO:0051480 9.56 TRPC5 TRPC6
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.54 TRPC5 TRPC6
7 neural crest cell migration GO:0001755 9.52 GDNF RET
8 regulation of cardiac muscle contraction GO:0055117 9.51 NKX2-5 NOS1
9 innervation GO:0060384 9.49 NTF4 RET
10 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.48 DMD NOS1
11 enteric nervous system development GO:0048484 9.43 GDNF RET
12 manganese ion transport GO:0006828 9.4 TRPC5 TRPC6
13 negative regulation of dendrite morphogenesis GO:0050774 9.37 TRPC5 TRPC6
14 neuron differentiation GO:0030182 9.26 DMD RET TRPC5 TRPC6
15 mechanoreceptor differentiation GO:0042490 9.16 NTF4 NTRK3
16 positive regulation of neuron differentiation GO:0045666 8.92 DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inositol 1,4,5 trisphosphate binding GO:0070679 9.16 TRPC5 TRPC6
2 actinin binding GO:0042805 8.96 TRPC5 TRPC6
3 store-operated calcium channel activity GO:0015279 8.62 TRPC5 TRPC6

Sources for Pyloric Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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