MCID: PYL006
MIFTS: 50

Pyloric Stenosis malady

Gastrointestinal diseases category
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Summaries for Pyloric Stenosis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards: Pyloric Stenosis, also known as acquired stenosis, is related to hirschsprung's disease and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and mptp have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Pyloric Stenosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

pyloric stenosis 8 10 45
acquired stenosis 62


External Ids:

Disease Ontology8 DOID:12639
NCIt40 C34966
SNOMED-CT58 367403001
MeSH35 D011707

Related Diseases for Pyloric Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease30.2GDNF
2hypertrophic pyloric stenosis11.4
3pylorospasm10.6
4esophagitis10.5
5neuronitis10.5
6eosinophilic gastroenteritis10.5
7duodenitis10.5
8gastroenteritis10.5
9crohn's disease10.4
10esophageal atresia10.4
11acquired gastric outlet stenosis10.4
12x-linked ichthyosis10.3
13pneumatosis cystoides intestinalis10.3
14epidermolysis bullosa10.3
15pertussis10.3
16tracheoesophageal fistula10.3
17epidermolysis bullosa, junctional, with pyloric stenosis10.3
18gastric outlet obstruction10.3
19duodenal ulcer10.2
20gilbert syndrome10.2
21gastric ulcer10.2
22epidermolysis bullosa simplex10.2
23junctional epidermolysis bullosa10.2
24gastric dilatation10.2
25congenital diaphragmatic hernia10.2
26pancreatitis10.2
27jejunal atresia10.2
28marden-walker syndrome10.2
29pyloric stenosis, infantile hypertrophic, 310.2
30pyloric stenosis, infantile hypertrophic 110.2
31pyloric stenosis, infantile hypertrophic, 210.2
32pyloric stenosis, infantile hypertrophic, 510.2
33pyloric stenosis, infantile hypertrophic, 410.2
34intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
35atrioventricular block10.1NKX2-5
36glomus tumor10.1DES
3721-hydroxylase deficiency10.1
38rothmund-thomson syndrome10.1
39cystic fibrosis10.1
40congenital adrenal hyperplasia10.1
41mesenteric lymphadenitis10.1
42ornithine carbamoyltransferase deficiency10.1
43phenylketonuria10.1
44dyspepsia10.1
45polyhydramnios10.1
46hypoglycemia10.1
47situs inversus10.1
48polycystic kidney disease10.1
49gastroduodenitis10.1
50nephrocalcinosis10.1

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Symptoms for Pyloric Stenosis

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Drugs & Therapeutics for Pyloric Stenosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

Genetic Tests for Pyloric Stenosis

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Anatomical Context for Pyloric Stenosis

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33MalaCards
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MalaCards organs/tissues related to Pyloric Stenosis:

33
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Testes, Ovary, Skin, Heart, Lung, Liver, Endothelial

Animal Models for Pyloric Stenosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pyloric Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6NOS1, HMOX2, NKX2-5, NGFR
2MP:00053818.4GDNF, NGFR, HMOX2, NOS1
3MP:00053768.1NOS1, HMOX2, NKX2-5, NGFR, DES
4MP:00053868.0GDNF, DES, NGFR, HMOX2, NOS1
5MP:00036317.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
6MP:00053697.7NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
7MP:00053857.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1
8MP:00107687.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1

Publications for Pyloric Stenosis

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52PubMed
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Articles related to Pyloric Stenosis:

(show top 50)    (show all 694)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
3
Images in clinical medicine. Peristaltic waves in pyloric stenosis. (24088114)
2013
4
Development of pyloric stenosis after a 4-day course of oral erythromycin. (23558266)
2013
5
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
6
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
7
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Proton pump inhibition is a feasible primary alternative to surgery and balloon dilatation in adult peptic pyloric stenosis (APS): report of six consecutive cases. (16551413)
2006
12
Familial pyloric stenosis associated with developmental delays. (15990644)
2005
13
Pyloric stenosis and neuronal nitric oxide synthase]. (15361336)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Junctional epidermolysis bullosa with pyloric stenosis. (11841649)
2001
16
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
17
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
18
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
19
Ectopic pancreas: a rare cause of pyloric stenosis. (10862516)
2000
20
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
21
Erythromycin use linked to pyloric stenosis. (10738394)
2000
22
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
23
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
24
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
25
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
26
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
27
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
28
Congenital pyloric stenosis: a modified umbilical incision for pyloromyotomy (9069247)
1997
29
Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. (8678208)
1996
30
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
31
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
32
Benign pyloric stenosis in an intrathoracic stomach. (7656368)
1995
33
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
34
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
35
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
36
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
37
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
38
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
39
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
40
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
41
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
42
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
43
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
44
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
45
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Pyloric Stenosis

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Expression for genes affiliated with Pyloric Stenosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

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Pathways for genes affiliated with Pyloric Stenosis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN
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Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis38
heme degradation38
Heme Biosynthesis38
heme biosynthesis38
heme biosynthesis from uroporphyrinogen-III I38
9.2HMOX2, UGT1A1
2
Show member pathways
9.0NOS1, NGFR, GDNF
39.0NOS1, NGFR, GDNF

Compounds for genes affiliated with Pyloric Stenosis

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45Novoseek, 29IUPHAR, 51PharmGKB, 24HMDB, 11DrugBank, 61Tocris Bioscience, 3BitterDB
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Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin4510.1HMOX2, NOS1
2mptp459.9NOS1, GDNF
3capsaicin45 2910.9NOS1, GDNF
4peroxynitrite459.7NGFR, NOS1
5guanylate459.6HMOX2, NOS1
6hematoxylin459.6DES, NGFR
7imipramine45 29 51 24 1113.6UGT1A1, NOS1
8dbc-amp459.5NGFR, GDNF
9norepinephrine45 24 1111.4NOS1, GDNF, DES
10choline45 24 1111.4GDNF, NGFR, NOS1
11creatinine459.4NOS1, GDNF, DES
12nadph45 2410.4NGFR, HMOX2, NOS1
13gaba459.4NGFR, NOS1, GDNF
14hydroxyurea45 51 1111.3UGT1A1, NOS1
15actinomycin d459.3DES, GDNF, HMOX2
16nmda45 2910.3NGFR, GDNF, NOS1
17iron45 2410.3HMOX2, DES, GDNF
18adenylate459.3GDNF, DES, NOS1
19ibuprofen45 29 51 24 1113.3NGFR, UGT1A1
20ganglioside459.2NGFR, DES, GDNF
21catecholamine459.2NGFR, GDNF
22h2o2459.2NOS1, DES, GDNF
23ethanol45 51 24 1112.2GDNF, NGFR, DES
24genistein45 29 61 3 24 1114.1GDNF, NOS1, UGT1A1
25nicotine45 29 51 1112.1UGT1A1, NOS1, NGFR
26aspartate459.1GDNF, NOS1, UGT1A1
27indomethacin45 29 61 1112.0NGFR, NOS1, UGT1A1
28cyclic amp45 2410.0GDNF, NGFR, DES
29morphine45 51 29 1112.0UGT1A1, NOS1
30dopamine45 29 24 1111.9GDNF, NGFR, HMOX2, NOS1
31superoxide45 249.9NGFR, NOS1, HMOX2, GDNF
32glutamate458.9GDNF, HMOX2, NOS1, NGFR
33testosterone45 61 24 1111.9UGT1A1, NOS1, DES
34vegf458.8GDNF, NOS1, DES, NGFR
35thymidine45 249.8NGFR, UGT1A1, DES
36cysteine458.8NOS1, GDNF, DES, NGFR
37glucose458.7NGFR, GDNF, HMOX2, DES
38arginine458.7HMOX2, DES, NOS1, UGT1A1
39dexamethasone45 51 29 1111.6NOS1, GDNF, NGFR, UGT1A1
40steroid458.5UGT1A1, NGFR, DES
41progesterone45 29 61 24 1112.5DES, UGT1A1, NGFR, HMOX2
42serine458.4NKX2-5, NGFR, DES, GDNF, NOS1
43acetylcholine45 51 29 24 1112.4HMOX2, NOS1, NGFR, GDNF, DES
44oxygen45 249.4GDNF, DES, NGFR, HMOX2, NOS1
45calcium45 51 24 1111.4GDNF, NOS1, HMOX2, DES, NGFR
46retinoic acid45 249.1GDNF, DES, UGT1A1, NOS1, NGFR
47nitric oxide45 24 1110.0NKX2-5, GDNF, NOS1, HMOX2, DES, NGFR
48tyrosine458.0NGFR, HMOX2, GDNF, UGT1A1, DES
49estrogen457.6UGT1A1, DES, GDNF, HMOX2, NOS1, NGFR

GO Terms for genes affiliated with Pyloric Stenosis

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16Gene Ontology
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Cellular components related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.6NOS1, DES

Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:0551179.7NKX2-5, NOS1
2heme catabolic processGO:0421679.3HMOX2, UGT1A1
3positive regulation of transcription from RNA polymerase II promoterGO:0459449.2NOS1, NKX2-5, GDNF
4porphyrin-containing compound metabolic processGO:0067789.1HMOX2, UGT1A1
5negative regulation of apoptotic processGO:0430668.6NGFR, NKX2-5, GDNF

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.7NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Pyloric Stenosis

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  • Antibodies
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Sources for Pyloric Stenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet