MCID: PYL006
MIFTS: 49

Pyloric Stenosis malady

Summaries for Pyloric Stenosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards: Pyloric Stenosis, also known as acquired stenosis, is related to esophagitis and achalasia. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Role of second messengers in netrin-1 signaling and Spinal Cord Injury. The compounds gv 150013 and gsmtx-4 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Pyloric Stenosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

pyloric stenosis 8 10 44
acquired stenosis 60


External Ids:

Disease Ontology8 DOID:12639
MeSH34 D011707
SNOMED-CT56 367403001
NCIt39 C34966

Related Diseases for Pyloric Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis30.7GAST
2achalasia30.2GAST, BLVRB, NOS1
3hirschsprung's disease30.0GDNF
4hypoglycemia30.0MLN, GAST
5cystic fibrosis30.0NGFR
6hypertrophic pyloric stenosis11.4
7pylorospasm10.5
8neuronitis10.4
9eosinophilic gastroenteritis10.4
10duodenitis10.4
11gastroenteritis10.4
12crohn's disease10.3
13esophageal atresia10.3
14acquired gastric outlet stenosis10.3
15gilbert syndrome10.3
16x-linked ichthyosis10.3
17pneumatosis cystoides intestinalis10.3
18epidermolysis bullosa10.3
19pertussis10.3
20epidermolysis bullosa, junctional, with pyloric stenosis10.3
21duodenal ulcer10.2
22epidermolysis bullosa simplex10.2
23junctional epidermolysis bullosa10.2
24gastric dilatation10.2
25tracheal stenosis10.2
26gastric ulcer10.2
27congenital diaphragmatic hernia10.2
28pancreatitis10.2
29pyloric stenosis, infantile hypertrophic, 310.2
30pyloric stenosis, infantile hypertrophic 110.2
31pyloric stenosis, infantile hypertrophic, 210.2
32pyloric stenosis, infantile hypertrophic, 510.2
33pyloric stenosis, infantile hypertrophic, 410.2
34intellectual deficit-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
35acquired tear duct stenosis10.1
3621-hydroxylase deficiency10.0
37vacterl association10.0
38smith-lemli-opitz syndrome10.0
39rothmund-thomson syndrome10.0
40cutis laxa10.0
41renal agenesis10.0
42plexiform schwannoma10.0
43congenital hypothyroidism10.0
44pseudohypoaldosteronism10.0
45hydronephrosis10.0
46systemic lupus erythematosus10.0
47gastroschisis10.0
48sudden infant death syndrome10.0
49arterial tortuosity syndrome10.0
50dyspepsia10.0

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Clinical Features for Pyloric Stenosis

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Drugs & Therapeutics for Pyloric Stenosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pyloric Stenosis

Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

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Genetic Tests for Pyloric Stenosis

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Anatomical Context for Pyloric Stenosis

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32MalaCards
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MalaCards organs/tissues related to Pyloric Stenosis:

32
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Endothelial, Heart, Lung, Liver, Ovary, Skin, Testes

Animal Models for Pyloric Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyloric Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.8NOS1, GAST, TRPC1, NGFR, HMOX2, GDNF
2MP:00053699.7DES, NKX2-5, TRPC6, NGFR, GDNF, HMOX2
3MP:00053859.3NOS1, NKX2-5, HMOX2, DES, GDNF, NGFR

Publications for Pyloric Stenosis

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50PubMed
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Articles related to Pyloric Stenosis:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Pyloromyotomy versus i.v. atropine therapy for the treatment of infantile pyloric stenosis: nationwide hospital discharge database analysis. (23489384)
2013
2
Postoperative emesis after laparoscopic pyloromyotomy in infantile hypertrophic pyloric stenosis. (24117731)
2013
3
Predictive factors of negative outcome in initial atropine therapy for infantile hypertrophic pyloric stenosis. (23701208)
2013
4
Pyloric stenosis in pediatric surgery: an evidence-based review. (22595707)
2012
5
Hypertrophic pyloric stenosis in the Third World. (21914675)
2011
6
The changing clinical presentation of hypertrophic pyloric stenosis: the experience of a large, tertiary care pediatric hospital. (21098534)
2011
7
Ranitidine may modify the biochemical disturbance in hypertrophic pyloric stenosis. (22295357)
2011
8
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
9
Adult pyloric stenosis masquerading as acute renal failure. (20058581)
2009
10
No association between a promoter NOS1 polymorphism (rs41279104) and Infantile Hypertrophic Pyloric Stenosis. (19851341)
2009
11
Ultrasound as a diagnostic tool used by surgeons in pyloric stenosis. (18206462)
2008
12
Effects of Rikkunshi-to on infantile hypertrophic pyloric stenosis, refractory to atropine. (18937758)
2008
13
Current management of hypertrophic pyloric stenosis. (17210480)
2007
14
Gastric outlet obstruction after long-term prostaglandin administration mimicking hypertrophic pyloric stenosis. (17968795)
2007
15
Conservative treatment of infantile hypertrophic pyloric stenosis with intravenous atropine sulfate does not replace pyloromyotomy. (17021743)
2006
16
A novel point mutation of the androgen receptor (F804L) in an Egyptian newborn with complete androgen insensitivity associated with congenital glaucoma and hypertrophic pyloric stenosis. (12519373)
2003
17
Erythromycin use during pregnancy in relation to pyloric stenosis. (11854652)
2002
18
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
19
Erythromycin-induced pyloric stenosis in infants. (11503852)
2001
20
Fluid resuscitation in infantile hypertrophic pyloric stenosis. (11430709)
2001
21
Ultrasonographic diagnosis criteria using scoring for hypertrophic pyloric stenosis. (11101721)
2000
22
Hunterian Lecture. The ontogeny of the peptide innervation of the human pylorus with special reference to understanding the aetiology and pathogenesis of infantile hypertrophic pyloric stenosis. (11103151)
2000
23
Is acid base determination an accurate predictor of pyloric stenosis? (11115037)
2000
24
A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis. (10663874)
2000
25
Pyloromyotomy versus atropine sulfate for infantile hypertrophic pyloric stenosis. (10693692)
2000
26
Jaundice with hypertrophic pyloric stenosis as an early manifestation of Gilbert syndrome. (10490432)
1999
27
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
28
The role of ultrasonography in the diagnosis of pyloric stenosis: a decision analysis. (9607467)
1998
29
Increased prevalence of urinary tract infections and anomalies in infants with pyloric stenosis. (9925002)
1998
30
Age-related changes in innervation in hypertrophic pyloric stenosis. (9434002)
1997
31
Congenital hypertrophic pyloric stenosis with associated polyhydramnios in a premature infant. (9241512)
1997
32
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
33
Who should treat pyloric stenosis: the general or specialist pediatric surgeon? (8943117)
1996
34
Through-the-scope balloon dilation for pyloric stenosis: long-term results. (8635729)
1996
35
Surgical technique of laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis. (8520173)
1995
36
Tuberculous mesenteric lymphadenitis presenting as pyloric stenosis. (7555442)
1995
37
Hypertrophic pyloric stenosis: ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal. (8583319)
1995
38
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
39
Investigation and diagnosis of hypertrophic pyloric stenosis. (1573614)
1992
40
Serum electrolytes and capillary blood gases in the management of hypertrophic pyloric stenosis. (1555094)
1992
41
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
42
A rational approach to the diagnosis of hypertrophic pyloric stenosis: do the results match the claims? (2406409)
1990
43
Abnormalities of peptide-containing nerve fibers in infantile hypertrophic pyloric stenosis. (2431951)
1987
44
Adult hypertrophic pyloric stenosis: case report. (3775682)
1986
45
Infantile hypertrophic pyloric stenosis--a study of fifty cases. (3744462)
1986
46
Serum gastrin levels and lower oesophageal sphincter pressures in infants with congenital hypertrophic pyloric stenosis. (6495875)
1984
47
Sonographic diagnosis of hypertrophic pyloric stenosis. (6620030)
1983
48
Ultrasound diagnosis of hypertrophic pyloric stenosis: real-time application and the demonstration of a new sonographic sign. (6836129)
1983
49
Association of antral diaphragms and hypertrophic pyloric stenosis. (97994)
1978
50
The value of the double-track sign as a differentiating factor between pylorospasm and hypertrophic pyloric stenosis in infants. (5934325)
1966

Genetic Variations for Pyloric Stenosis

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Expression for genes affiliated with Pyloric Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

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Pathways for genes affiliated with Pyloric Stenosis

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TRPC6, TRPC1
210.2NOS1, GDNF, NGFR
3
Hide members
10.1UGT1A1, BLVRB, HMOX2
4
Hide members
10.1HMOX2, BLVRB, UGT1A1

Compounds for genes affiliated with Pyloric Stenosis

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44Novoseek, 28IUPHAR, 24HMDB, 2BitterDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1gv 1500134410.6GAST, NOS1
2gsmtx-42810.6TRPC1, TRPC6
3trimebutine4410.5GAST, MLN
4hematoxylin4410.5S100B, DES, BLVRB
5orcein4410.5DES, S100B
6skf 963654410.5TRPC6, TRPC1
7ng-nitro-l-arginine4410.5NOS1, BLVRB, GAST
8lafutidine4410.5MLN, GAST
9catecholamine4410.4S100B, BLVRB, NGFR, GDNF
10skf963652810.4TRPC6, TRPC1
11biliverdin44 2411.4HMOX2, BLVRB
12acetaminophen44 2 49 11 2414.4UGT1A1
13nicotine44 49 28 1113.4NOS1, NGFR, UGT1A1, GAST
14choline44 11 2412.4S100B, BLVRB, NGFR, GDNF, NOS1
15capsaicin44 2811.4NOS1, GDNF, TRPC1
16bromodeoxyuridine4410.3GDNF, DES, GAST, S100B
17formaldehyde44 2411.3S100B, DES, BLVRB, TYMP, NOS1
18indomethacin44 59 28 1113.3UGT1A1, BLVRB, TYMP, NGFR, NOS1
19s 1004410.3S100B, DES
20atropine44 28 1112.3GAST, MLN, NOS1
21ethanol44 49 11 2413.3S100B, DES, BLVRB, NGFR, GDNF
22norepinephrine44 11 2412.3S100B, GAST, DES, GDNF, NOS1
23nadph44 2411.3S100B, BLVRB, NGFR, HMOX2, NOS1
24ganglioside4410.3GDNF, NGFR, DES
25paraffin4410.2S100B, DES, BLVRB, TYMP, NGFR
26gaba4410.2S100B, GAST, BLVRB, NGFR, GDNF, NOS1
27superoxide44 2411.2BLVRB, NGFR, GDNF, HMOX2, NOS1
28iron44 2411.2S100B, DES, BLVRB, GDNF, HMOX2
29thymidine44 2411.2S100B, GAST, UGT1A1, DES, TYMP, NGFR
30creatinine4410.2S100B, GAST, DES, TYMP, GDNF, NOS1
31bethanechol44 28 1112.2MLN, GAST
32dexamethasone44 49 28 1113.2S100B, GAST, UGT1A1, NGFR, GDNF, NOS1
33testosterone44 59 11 2413.1S100B, GAST, UGT1A1, DES, BLVRB, NOS1
34vegf4410.1S100B, GAST, DES, TYMP, NGFR, GDNF
35glutamate4410.1S100B, GAST, BLVRB, NGFR, GDNF, HMOX2
36arginine4410.1S100B, UGT1A1, MLN, DES, BLVRB, HMOX2
37dbc-amp4410.1GDNF, NGFR, S100B
38adenylate4410.0S100B, GAST, MLN, DES, BLVRB, GDNF
39oxygen44 2411.0S100B, DES, BLVRB, TYMP, NGFR, GDNF
40alanine4410.0S100B, GAST, UGT1A1, MLN, GDNF, NOS1
41heparin44 28 11 2413.0S100B, GAST, MLN, DES, GDNF
42progesterone44 59 28 11 2414.0S100B, UGT1A1, MLN, DES, BLVRB, TYMP
43dopamine44 28 11 2413.0S100B, GAST, MLN, BLVRB, NGFR, GDNF
44gd3+289.9TRPC6, TRPC1
45acetylcholine44 49 28 11 2413.9NOS1, S100B, GAST, MLN, DES, BLVRB
46serine449.9S100B, GAST, MLN, DES, NKX2-5, TYMP
47glucose449.8S100B, GAST, MLN, DES, BLVRB, TYMP
48tyrosine449.7S100B, GAST, UGT1A1, MLN, DES, BLVRB
49nitric oxide44 11 2411.6S100B, MLN, DES, NKX2-5, TRPC1, BLVRB
50calcium44 49 11 2412.6S100B, GAST, MLN, DES, TRPC1, TRPC6

GO Terms for genes affiliated with Pyloric Stenosis

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16Gene Ontology
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Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:04216710.1HMOX2, BLVRB, UGT1A1
2porphyrin-containing compound metabolic processGO:00677810.0HMOX2, BLVRB, UGT1A1
3regulation of cardiac muscle contractionGO:05511710.0NKX2-5, NOS1
4axon guidanceGO:00741110.0GDNF, NGFR, TRPC6, TRPC1

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:01527910.2TRPC6, TRPC1
2inositol 1,4,5 trisphosphate bindingGO:0706799.9TRPC6, TRPC1

Products for genes affiliated with Pyloric Stenosis

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Sources for Pyloric Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet