MCID: PYL006
MIFTS: 44

Pyloric Stenosis malady

Summaries for Pyloric Stenosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards: Pyloric Stenosis, also known as acquired stenosis, is related to hirschsprung's disease and achalasia. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Role of second messengers in netrin-1 signaling and Spinal Cord Injury. The compounds gv 150013 and gsmtx-4 have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Pyloric Stenosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

pyloric stenosis 8 10 45
acquired stenosis 61


External Ids:

Disease Ontology8 DOID:12639
MeSH35 D011707
SNOMED-CT57 367403001
NCIt40 C34966

Related Diseases for Pyloric Stenosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease30.3GDNF
2achalasia30.3GAST, BLVRB, NOS1
3gastric outlet obstruction30.3GAST, MLN
4hypoglycemia30.0MLN, GAST
5cystic fibrosis30.0NGFR
6hypertrophic pyloric stenosis11.4
7pyloric stenosis, infantile hypertrophic 110.6
8pylorospasm10.6
9eosinophilic gastroenteritis10.4
10pyloric stenosis, infantile hypertrophic, 210.4
11crohn's disease10.3
12esophageal atresia10.3
13gilbert syndrome10.3
14pneumatosis cystoides intestinalis10.3
15acquired gastric outlet stenosis10.3
16tracheoesophageal fistula10.3
17epidermolysis bullosa, junctional, with pyloric stenosis10.3
18duodenal ulcer10.2
19epidermolysis bullosa simplex10.2
20junctional epidermolysis bullosa10.2
21gastric dilatation10.2
22tracheal stenosis10.2
23gastric ulcer10.2
24congenital diaphragmatic hernia10.2
25esophageal atresia/tracheoesophageal fistula10.2
26jejunal atresia10.2
27marden-walker syndrome10.2
28pyloric stenosis, infantile hypertrophic, 310.2
29pyloric stenosis, infantile hypertrophic, 510.2
30pyloric stenosis, infantile hypertrophic, 410.2
31intellectual deficit-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
32acquired tear duct stenosis10.1
33vacterl association10.0
34smith-lemli-opitz syndrome10.0
35rothmund-thomson syndrome10.0
36cutis laxa10.0
37renal agenesis10.0
38plexiform schwannoma10.0
39congenital hypothyroidism10.0
40pseudohypoaldosteronism10.0
41hydronephrosis10.0
42systemic lupus erythematosus10.0
43gastroschisis10.0
44sudden infant death syndrome10.0
45arterial tortuosity syndrome10.0
46wernicke encephalopathy10.0
47dyspepsia10.0
48congenital adrenal hyperplasia10.0
49mesenteric lymphadenitis10.0
50phenylketonuria10.0

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Clinical Features for Pyloric Stenosis

Drugs & Therapeutics for Pyloric Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pyloric Stenosis

Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

Search CenterWatch for Pyloric Stenosis

Genetic Tests for Pyloric Stenosis

Anatomical Context for Pyloric Stenosis

Animal Models for Pyloric Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pyloric Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.8NOS1, GAST, TRPC1, NGFR, HMOX2, GDNF
2MP:00053699.7DES, NKX2-5, TRPC6, NGFR, GDNF, HMOX2
3MP:00053859.3NOS1, NKX2-5, HMOX2, DES, GDNF, NGFR

Publications for Pyloric Stenosis

Sources:
51PubMed
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Articles related to Pyloric Stenosis:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Images in clinical medicine. Peristaltic waves in pyloric stenosis. (24088114)
2013
2
Gastric pneumatosis secondary to pyloric stenosis. (23480927)
2013
3
The association of molybdenum cofactor deficiency and pyloric stenosis. (23128059)
2012
4
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. (22306654)
2012
5
Can you be too premature to develop pyloric stenosis? (23008371)
2012
6
Preliminary experience with a new approach for infantile hypertrophic pyloric stenosis: the single-port, laparoscopic-assisted pyloromyotomy. (21136088)
2011
7
An adult case of eosinophilic pyloric stenosis maintained on remission with oral budesonide. (21409859)
2011
8
Early developmental outcome of infants with infantile hypertrophic pyloric stenosis. (21129547)
2010
9
A rare presentation in a case of gastric duplication cyst communicating to the pancreatic duct: coincidental detection during pyloromyotomy for hypertrophic pyloric stenosis. (18778980)
2008
10
Recurrent pyloric stenosis: to dilate or operate? A preliminary report. (18280264)
2008
11
Hypertrophic pyloric stenosis in newborns younger than 21 days: remodeling the path of surgical intervention. (18558172)
2008
12
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
13
Are young infants treated with erythromycin at risk for developing hypertrophic pyloric stenosis? (17337692)
2007
14
Pyloric stenosis as a presenting symptom of Crohn's disease. (16802014)
2006
15
Evaluation of a Bayesian decision network for diagnosing pyloric stenosis. (16410126)
2006
16
Antral web associated with distal antral hypertrophy and prepyloric stenosis mimicking hypertrophic pyloric stenosis. (15641157)
2005
17
A histological study of the hph-1 mouse mutant: an animal model of phenylketonuria and infantile hypertrophic pyloric stenosis. (15144277)
2004
18
Pyloric stenosis. (17378966)
2004
19
Pyloric stenosis and pyloric atresia: the same pathogenesis? (12071832)
2002
20
A randomized multicenter study of remifentanil compared with halothane in neonates and infants undergoing pyloromyotomy. II. Perioperative breathing patterns in neonates and infants with pyloric stenosis. (11726412)
2001
21
Palliation of pyloric stenosis caused by gastric cancer using an endoscopically placed covered ultraflex stent: covered stent inside an occluded uncovered stent. (10960550)
2000
22
Delineation of a new syndrome: clustering of pyloric stenosis, endometriosis, and breast cancer in two families. (11183186)
2000
23
Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. (10634345)
1999
24
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
25
Increased insulin-like growth factor and platelet-derived growth factor system in the pyloric muscle in infantile hypertrophic pyloric stenosis. (9498422)
1998
26
Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. (9553181)
1998
27
Pyloric stenosis due to Crohn's disease. (9773942)
1998
28
Gastric carcinoma with pyloric stenosis. (9526526)
1998
29
Congenital pyloric stenosis: a modified umbilical incision for pyloromyotomy (9069247)
1997
30
Prognostic factors of the postoperative vomiting in case of hypertrophic pyloric stenosis. (9165255)
1997
31
Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. (8678208)
1996
32
Changing patterns of diagnosis and treatment of infantile hypertrophic pyloric stenosis: a clinical audit of 303 patients. (8986971)
1996
33
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
34
Pyloric stenosis is a pediatrician's diagnosis. (8008463)
1994
35
Prognosis of patients with gastric cancer and pyloric stenosis: histological differentiation. (8052781)
1994
36
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. (8237916)
1993
37
Infantile hypertrophic pyloric stenosis: a clinical review from a general hospital. (8240866)
1993
38
Sonography of hypertrophic pyloric stenosis: frequency and cause of nonuniform echogenicity of the thickened pyloric muscle. (1727338)
1992
39
Increasing infantile hypertrophic pyloric stenosis? Experience in an overseas military hospital. (1757904)
1991
40
Physical examination for 'initial evaluation' of hypertrophic pyloric stenosis. (2301312)
1990
41
Jaundice with hypertrophic pyloric stenosis: a possible manifestation of Gilbert syndrome. (2348286)
1990
42
The significance of alkalosis and hypochloremia in hypertrophic pyloric stenosis. (2593055)
1989
43
Changing patterns in the diagnosis of hypertrophic pyloric stenosis. (3277156)
1988
44
Infantile hypertrophic pyloric stenosis and subsequent ulcer dyspepsia. A follow-up study of medically and surgically treated patients. (3232484)
1988
45
Sonography of hypertrophic pyloric stenosis. (3900557)
1985
46
Infantile hypertrophic pyloric stenosis in South Glamorgan 1970-9. Effects of changes in feeding practice. (6614972)
1983
47
Hypertrophic pyloric stenosis associated with X-linked ichthyosis in two brothers. (6682359)
1983
48
Changing incidence of infantile hypertrophic pyloric stenosis. (6614971)
1983
49
Infantile hypertrophic pyloric stenosis: surgical experience of 24 cases. (7344572)
1981
50
Pyloric stenosis following pylorospasm. (18934574)
1948

Genetic Variations for Pyloric Stenosis

Expression for genes affiliated with Pyloric Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for genes affiliated with Pyloric Stenosis

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TRPC6, TRPC1
210.2NGFR, GDNF, NOS1
3
Hide members
10.1UGT1A1, HMOX2, BLVRB
4
Hide members
10.1UGT1A1, BLVRB, HMOX2

Compounds for genes affiliated with Pyloric Stenosis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 2BitterDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
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Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1gv 1500134510.6GAST, NOS1
2gsmtx-42910.6TRPC1, TRPC6
3trimebutine4510.5GAST, MLN
4hematoxylin4510.5S100B, DES, BLVRB
5orcein4510.5DES, S100B
6skf 963654510.5TRPC6, TRPC1
7ng-nitro-l-arginine4510.5NOS1, BLVRB, GAST
8lafutidine4510.5MLN, GAST
9catecholamine4510.4S100B, BLVRB, NGFR, GDNF
10skf963652910.4TRPC6, TRPC1
11biliverdin45 2411.4HMOX2, BLVRB
12acetaminophen45 2 50 11 2414.4UGT1A1
13nicotine45 50 29 1113.4NOS1, NGFR, UGT1A1, GAST
14choline45 11 2412.4S100B, BLVRB, NGFR, GDNF, NOS1
15capsaicin45 2911.4NOS1, GDNF, TRPC1
16bromodeoxyuridine4510.3GDNF, DES, GAST, S100B
17formaldehyde45 2411.3S100B, DES, BLVRB, TYMP, NOS1
18indomethacin45 60 29 1113.3UGT1A1, BLVRB, TYMP, NGFR, NOS1
19s 1004510.3S100B, DES
20atropine45 29 1112.3GAST, MLN, NOS1
21ethanol45 50 11 2413.3S100B, DES, BLVRB, NGFR, GDNF
22norepinephrine45 11 2412.3S100B, GAST, DES, GDNF, NOS1
23nadph45 2411.3S100B, BLVRB, NGFR, HMOX2, NOS1
24ganglioside4510.3GDNF, NGFR, DES
25paraffin4510.2S100B, DES, BLVRB, TYMP, NGFR
26gaba4510.2S100B, GAST, BLVRB, NGFR, GDNF, NOS1
27superoxide45 2411.2BLVRB, NGFR, GDNF, HMOX2, NOS1
28iron45 2411.2S100B, DES, BLVRB, GDNF, HMOX2
29thymidine45 2411.2S100B, GAST, UGT1A1, DES, TYMP, NGFR
30creatinine4510.2S100B, GAST, DES, TYMP, GDNF, NOS1
31bethanechol45 29 1112.2MLN, GAST
32dexamethasone45 50 29 1113.2S100B, GAST, UGT1A1, NGFR, GDNF, NOS1
33testosterone45 60 11 2413.1S100B, GAST, UGT1A1, DES, BLVRB, NOS1
34vegf4510.1S100B, GAST, DES, TYMP, NGFR, GDNF
35glutamate4510.1S100B, GAST, BLVRB, NGFR, GDNF, HMOX2
36arginine4510.1S100B, UGT1A1, MLN, DES, BLVRB, HMOX2
37dbc-amp4510.1GDNF, NGFR, S100B
38adenylate4510.0S100B, GAST, MLN, DES, BLVRB, GDNF
39oxygen45 2411.0S100B, DES, BLVRB, TYMP, NGFR, GDNF
40alanine4510.0S100B, GAST, UGT1A1, MLN, GDNF, NOS1
41heparin45 29 11 2413.0S100B, GAST, MLN, DES, GDNF
42progesterone45 60 29 11 2414.0S100B, UGT1A1, MLN, DES, BLVRB, TYMP
43dopamine45 29 11 2413.0S100B, GAST, MLN, BLVRB, NGFR, GDNF
44gd3+299.9TRPC6, TRPC1
45acetylcholine45 50 29 11 2413.9NOS1, S100B, GAST, MLN, DES, BLVRB
46serine459.9S100B, GAST, MLN, DES, NKX2-5, TYMP
47glucose459.8S100B, GAST, MLN, DES, BLVRB, TYMP
48tyrosine459.7S100B, GAST, UGT1A1, MLN, DES, BLVRB
49nitric oxide45 11 2411.6S100B, MLN, DES, NKX2-5, TRPC1, BLVRB
50calcium45 50 11 2412.6S100B, GAST, MLN, DES, TRPC1, TRPC6

GO Terms for genes affiliated with Pyloric Stenosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:04216710.1UGT1A1, BLVRB, HMOX2
2porphyrin-containing compound metabolic processGO:00677810.0HMOX2, BLVRB, UGT1A1
3regulation of cardiac muscle contractionGO:05511710.0NOS1, NKX2-5
4axon guidanceGO:00741110.0TRPC6, NGFR, GDNF, TRPC1

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:01527910.2TRPC6, TRPC1
2inositol 1,4,5 trisphosphate bindingGO:0706799.9TRPC6, TRPC1

Products for genes affiliated with Pyloric Stenosis

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Sources for Pyloric Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet