MCID: PYL006
MIFTS: 41

Pyloric Stenosis malady

Summaries for Pyloric Stenosis

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Wikipedia:63 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards based summary: Pyloric Stenosis is related to hypertrophic pyloric stenosis and pylorospasm. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and mptp have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Pyloric Stenosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 55SNOMED-CT, 38NCIt, 33MeSH, 60UMLS
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Pyloric Stenosis, Aliases & Descriptions:

Name: Pyloric Stenosis 9 11 43


External Ids:

Disease Ontology9 DOID:12639
NCIt38 C34966
SNOMED-CT55 367403001
MeSH33 D011707

Related Diseases for Pyloric Stenosis

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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic pyloric stenosis11.4
2pylorospasm10.6
3esophagitis10.5
4neuronitis10.5
5eosinophilic gastroenteritis10.5
6duodenitis10.5
7gastroenteritis10.5
8acquired gastric outlet stenosis10.4
9atrioventricular block10.4NKX2-5
10hirschsprung disease 110.4GDNF
11pyloric stenosis, infantile hypertrophic, 310.4
12pyloric stenosis, infantile hypertrophic, 210.4
13pyloric stenosis, infantile hypertrophic, 510.4
14marden-walker syndrome10.4
15pyloric stenosis, infantile hypertrophic, 410.4
16crohn's disease10.4
17esophageal atresia10.4
18gastric outlet obstruction10.4
19glomus tumor10.3DES
20smith-lemli-opitz syndrome10.3
21jacobsen syndrome10.3
22ulnar-mammary syndrome10.3
23koolen-de vries syndrome10.3
24intestinal pseudoobstruction, neuronal10.3
25epidermolysis bullosa, junctional, with pyloric stenosis10.3
26gilbert syndrome10.3
27gastric dilatation10.3
28pneumatosis cystoides intestinalis10.3
29epidermolysis bullosa10.3
30pertussis10.3
31tracheoesophageal fistula10.3
32intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.3
33neonatal jaundice10.3UGT1A1
34epidermolysis bullosa, junctional, non-herlitz type10.2
35kleefstra syndrome10.2
36gastroesophageal reflux10.2
37renal cysts and diabetes syndrome10.2
38arterial tortuosity syndrome10.2
39ornithine transcarbamylase deficiency10.2
40hypoparathyroidism, sensorineural deafness, and renal dysplasia10.2
41heterotopia, periventricular, ed variant10.2
42chronic granulomatous disease10.2
43duodenal ulcer10.2
44gastric ulcer10.2
45cornelia de lange syndrome10.2
46epidermolysis bullosa simplex10.2
47junctional epidermolysis bullosa10.2
48achalasia10.2
49congenital diaphragmatic hernia10.2
50gastritis10.2

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Symptoms for Pyloric Stenosis

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Drugs & Therapeutics for Pyloric Stenosis

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Drug clinical trials:

Search ClinicalTrials for Pyloric Stenosis

Search NIH Clinical Center for Pyloric Stenosis

Genetic Tests for Pyloric Stenosis

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Anatomical Context for Pyloric Stenosis

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MalaCards organs/tissues related to Pyloric Stenosis:

31
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Brain, Heart, Liver, Lung, Skin, Ovary, Testes, Endothelial

Animal Models for Pyloric Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Pyloric Stenosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6NOS1, HMOX2, NKX2-5, NGFR
2MP:00053818.4GDNF, NGFR, HMOX2, NOS1
3MP:00053768.1NOS1, HMOX2, NKX2-5, NGFR, DES
4MP:00053868.0GDNF, DES, NGFR, HMOX2, NOS1
5MP:00036317.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
6MP:00053697.7NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
7MP:00053857.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1
8MP:00107687.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1

Publications for Pyloric Stenosis

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Articles related to Pyloric Stenosis:

(show top 50)    (show all 733)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
3
Images in clinical medicine. Peristaltic waves in pyloric stenosis. (24088114)
2013
4
Development of pyloric stenosis after a 4-day course of oral erythromycin. (23558266)
2013
5
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
6
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
7
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Proton pump inhibition is a feasible primary alternative to surgery and balloon dilatation in adult peptic pyloric stenosis (APS): report of six consecutive cases. (16551413)
2006
12
Familial pyloric stenosis associated with developmental delays. (15990644)
2005
13
Pyloric stenosis and neuronal nitric oxide synthase]. (15361336)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Junctional epidermolysis bullosa with pyloric stenosis. (11841649)
2001
16
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
17
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
18
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
19
Ectopic pancreas: a rare cause of pyloric stenosis. (10862516)
2000
20
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
21
Erythromycin use linked to pyloric stenosis. (10738394)
2000
22
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
23
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
24
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
25
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
26
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
27
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
28
Congenital pyloric stenosis: a modified umbilical incision for pyloromyotomy (9069247)
1997
29
Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. (8678208)
1996
30
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
31
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
32
Benign pyloric stenosis in an intrathoracic stomach. (7656368)
1995
33
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
34
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
35
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
36
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
37
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
38
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
39
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
40
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
41
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
42
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
43
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
44
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
45
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Pyloric Stenosis

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Expression for genes affiliated with Pyloric Stenosis

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Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for genes affiliated with Pyloric Stenosis

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Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.2HMOX2, UGT1A1
2
Show member pathways
9.0NOS1, NGFR, GDNF
39.0NOS1, NGFR, GDNF

Compounds for genes affiliated with Pyloric Stenosis

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Compounds related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin4310.1NOS1, HMOX2
2mptp439.9GDNF, NOS1
3capsaicin43 2810.9GDNF, NOS1
4peroxynitrite439.7NGFR, NOS1
5guanylate439.6NOS1, HMOX2
6hematoxylin439.6DES, NGFR
7imipramine43 28 49 24 1213.6UGT1A1, NOS1
8dbc-amp439.5NGFR, GDNF
9norepinephrine43 24 1211.4GDNF, DES, NOS1
10choline43 24 1211.4NOS1, NGFR, GDNF
11creatinine439.4GDNF, DES, NOS1
12nadph43 2410.4NGFR, HMOX2, NOS1
13gaba439.4NOS1, NGFR, GDNF
14hydroxyurea43 49 1211.3UGT1A1, NOS1
15actinomycin d439.3HMOX2, DES, GDNF
16nmda43 2810.3NOS1, NGFR, GDNF
17iron43 2410.3HMOX2, DES, GDNF
18adenylate439.3NOS1, DES, GDNF
19ibuprofen43 28 49 24 1213.3UGT1A1, NGFR
20ganglioside439.2NGFR, DES, GDNF
21catecholamine439.2GDNF, NGFR
22h2o2439.2GDNF, DES, NOS1
23ethanol43 49 24 1212.2NGFR, DES, GDNF
24genistein43 28 59 2 24 1214.1NOS1, UGT1A1, GDNF
25nicotine43 28 49 1212.1NOS1, NGFR, UGT1A1
26aspartate439.1NOS1, UGT1A1, GDNF
27indomethacin43 28 59 1212.0UGT1A1, NGFR, NOS1
28cyclic amp43 2410.0NGFR, DES, GDNF
29morphine43 49 28 1212.0NOS1, UGT1A1
30dopamine43 28 24 1211.9GDNF, NGFR, HMOX2, NOS1
31superoxide43 249.9NOS1, HMOX2, NGFR, GDNF
32glutamate438.9GDNF, NGFR, HMOX2, NOS1
33testosterone43 59 24 1211.9NOS1, UGT1A1, DES
34vegf438.8GDNF, DES, NGFR, NOS1
35thymidine43 249.8NGFR, UGT1A1, DES
36cysteine438.8GDNF, DES, NGFR, NOS1
37glucose438.7GDNF, DES, NGFR, HMOX2
38arginine438.7DES, UGT1A1, HMOX2, NOS1
39dexamethasone43 49 28 1211.6GDNF, UGT1A1, NGFR, NOS1
40steroid438.5NGFR, UGT1A1, DES
41progesterone43 28 59 24 1212.5DES, UGT1A1, NGFR, HMOX2
42serine438.4GDNF, DES, NGFR, NKX2-5, NOS1
43acetylcholine43 49 28 24 1212.4GDNF, DES, NGFR, HMOX2, NOS1
44oxygen43 249.4GDNF, DES, NGFR, HMOX2, NOS1
45calcium43 49 24 1211.4NOS1, HMOX2, NGFR, DES, GDNF
46retinoic acid43 249.1GDNF, DES, UGT1A1, NGFR, NOS1
47nitric oxide43 24 1210.0NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
48tyrosine438.0GDNF, DES, UGT1A1, NGFR, HMOX2
49estrogen437.6GDNF, DES, UGT1A1, NGFR, HMOX2, NOS1

GO Terms for genes affiliated with Pyloric Stenosis

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Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:00423839.6NOS1, DES

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:00551179.7NOS1, NKX2-5
2heme catabolic processGO:00421679.3HMOX2, UGT1A1
3positive regulation of transcription from RNA polymerase II promoterGO:00459449.2NOS1, NKX2-5, GDNF
4porphyrin-containing compound metabolic processGO:00067789.1HMOX2, UGT1A1
5negative regulation of apoptotic processGO:00430668.6GDNF, NGFR, NKX2-5

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428038.7NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Pyloric Stenosis

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Sources for Pyloric Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet