MCID: PYL006
MIFTS: 50

Pyloric Stenosis malady

Gastrointestinal diseases category

Summaries for Pyloric Stenosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pyloric stenosis or pylorostenosis is narrowing (stenosis) of the opening from the stomach to the first... more...

MalaCards: Pyloric Stenosis, also known as acquired stenosis, is related to hirschsprung's disease and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (nitric oxide synthase 1 (neuronal)), and among its related pathways are Metabolism of porphyrins and PEDF Induced Signaling. The compounds zinc protoporphyrin and mptp have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and breast, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Pyloric Stenosis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

pyloric stenosis 9 11 46
acquired stenosis 63


External Ids:

Disease Ontology9 DOID:12639
NCIt41 C34966
SNOMED-CT59 367403001
MeSH36 D011707

Related Diseases for Pyloric Stenosis

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18GeneCards, 19GeneDecks
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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease30.2GDNF
2hypertrophic pyloric stenosis11.4
3pylorospasm10.6
4esophagitis10.5
5neuronitis10.5
6eosinophilic gastroenteritis10.5
7duodenitis10.5
8gastroenteritis10.5
9crohn's disease10.4
10esophageal atresia10.4
11acquired gastric outlet stenosis10.4
12x-linked ichthyosis10.3
13pneumatosis cystoides intestinalis10.3
14epidermolysis bullosa10.3
15pertussis10.3
16tracheoesophageal fistula10.3
17epidermolysis bullosa, junctional, with pyloric stenosis10.3
18gastric outlet obstruction10.3
19duodenal ulcer10.2
20gilbert syndrome10.2
21gastric ulcer10.2
22epidermolysis bullosa simplex10.2
23junctional epidermolysis bullosa10.2
24gastric dilatation10.2
25congenital diaphragmatic hernia10.2
26pancreatitis10.2
27jejunal atresia10.2
28marden-walker syndrome10.2
29pyloric stenosis, infantile hypertrophic, 310.2
30pyloric stenosis, infantile hypertrophic 110.2
31pyloric stenosis, infantile hypertrophic, 210.2
32pyloric stenosis, infantile hypertrophic, 510.2
33pyloric stenosis, infantile hypertrophic, 410.2
34intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome10.2
35atrioventricular block10.1NKX2-5
36glomus tumor10.1DES
3721-hydroxylase deficiency10.1
38rothmund-thomson syndrome10.1
39cystic fibrosis10.1
40congenital adrenal hyperplasia10.1
41mesenteric lymphadenitis10.1
42ornithine carbamoyltransferase deficiency10.1
43phenylketonuria10.1
44dyspepsia10.1
45polyhydramnios10.1
46hypoglycemia10.1
47situs inversus10.1
48polycystic kidney disease10.1
49gastroduodenitis10.1
50nephrocalcinosis10.1

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to pyloric stenosis

Symptoms for Pyloric Stenosis

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Drugs & Therapeutics for Pyloric Stenosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pyloric Stenosis

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Anatomical Context for Pyloric Stenosis

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34MalaCards
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MalaCards organs/tissues related to Pyloric Stenosis:

34
Small intestine, Pancreas, Breast, Smooth muscle, Kidney, Testes, Ovary, Skin, Heart, Lung, Liver, Endothelial

Animal Models for Pyloric Stenosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pyloric Stenosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6NOS1, HMOX2, NKX2-5, NGFR
2MP:00053818.4GDNF, NGFR, HMOX2, NOS1
3MP:00053768.1NOS1, HMOX2, NKX2-5, NGFR, DES
4MP:00053868.0GDNF, DES, NGFR, HMOX2, NOS1
5MP:00036317.8GDNF, NGFR, NKX2-5, HMOX2, NOS1
6MP:00053697.7NOS1, HMOX2, NKX2-5, NGFR, DES, GDNF
7MP:00053857.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1
8MP:00107687.7GDNF, DES, NGFR, NKX2-5, HMOX2, NOS1

Publications for Pyloric Stenosis

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53PubMed
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Articles related to Pyloric Stenosis:

(show top 50)    (show all 694)
idTitleAuthorsYear
1
Infantile hypertrophic pyloric stenosis: has anything changed? (23198903)
2013
2
Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. (24146084)
2013
3
Images in clinical medicine. Peristaltic waves in pyloric stenosis. (24088114)
2013
4
Development of pyloric stenosis after a 4-day course of oral erythromycin. (23558266)
2013
5
Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. (21293220)
2011
6
The role of RET genomic variants in infantile hypertrophic pyloric stenosis. (22169991)
2011
7
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
8
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
9
Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy. (17934821)
2008
10
Ultrasonographic serial measurements of the morphologic resolution of the pylorus after Ramstedt pyloromyotomy for infantile hypertrophic pyloric stenosis. (18029919)
2007
11
Proton pump inhibition is a feasible primary alternative to surgery and balloon dilatation in adult peptic pyloric stenosis (APS): report of six consecutive cases. (16551413)
2006
12
Familial pyloric stenosis associated with developmental delays. (15990644)
2005
13
Pyloric stenosis and neuronal nitric oxide synthase]. (15361336)
2004
14
Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. (12090829)
2002
15
Junctional epidermolysis bullosa with pyloric stenosis. (11841649)
2001
16
Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. (11562617)
2001
17
Absence of Epstein-Barr virus in smooth muscle cells of idiopathic hypertrophic pyloric stenosis. (11231484)
2001
18
In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? (11566686)
2001
19
Ectopic pancreas: a rare cause of pyloric stenosis. (10862516)
2000
20
Infantile hypertrophic pyloric stenosis in a 5-month-old baby: case report. (10974761)
2000
21
Erythromycin use linked to pyloric stenosis. (10738394)
2000
22
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
23
Pyloric muscle in asymptomatic infants: sonographic evaluation and discrimination from idiopathic hypertrophic pyloric stenosis. (9634457)
1998
24
Ultrasonographic follow-up of the healing process of medically treated hypertrophic pyloric stenosis. (9561540)
1998
25
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. (9805307)
1998
26
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
27
Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. (9354728)
1997
28
Congenital pyloric stenosis: a modified umbilical incision for pyloromyotomy (9069247)
1997
29
Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. (8678208)
1996
30
Early infantile hypertrophic pyloric stenosis: surgery at 26 hours of age. (8877358)
1996
31
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
32
Benign pyloric stenosis in an intrathoracic stomach. (7656368)
1995
33
The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. (8162680)
1994
34
An analysis of feeding regimens after pyloromyotomy for hypertrophic pyloric stenosis. (8301463)
1993
35
Infantile hypertrophic pyloric stenosis: myopathic type. (2169173)
1990
36
Multinodular adult hypertrophic pyloric stenosis. (2584668)
1989
37
Does earlier admission in infantile hypertrophic pyloric stenosis (IHPS) apparently increase incidence rates? (3335980)
1988
38
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986
39
Infantile hypertrophic pyloric stenosis: a review of 222 cases. (3460546)
1986
40
300 infants with hypertrophic pyloric stenosis: presentation and outcome. (3721820)
1986
41
The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis. (3458896)
1986
42
Report of two patients with hypertrophic pyloric stenosis and Hirschsprung's disease. Coincident or common etiology? (4026078)
1985
43
Muscle thickness in hypertrophic pyloric stenosis: sonographic determination. (6600332)
1983
44
Infantile hypertrophic pyloric stenosis--congenital or acquired? (7077061)
1982
45
Infantile hypertrophic pyloric stenosis -- a rarity in Malaysia? (7167088)
1982
46
X-linked ichthyosis associated with hypertrophic pyloric stenosis in three brothers. (7196302)
1981
47
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis. (7421172)
1980
48
Idiopathic hypertrophic pyloric stenosis in adults. (7401003)
1980
49
Late presentation of hypertrophic pyloric stenosis. (470691)
1979
50
Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis. (117092)
1979

Variations for Pyloric Stenosis

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Expression for genes affiliated with Pyloric Stenosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyloric Stenosis

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Pathways for genes affiliated with Pyloric Stenosis

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Pyloric Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.2HMOX2, UGT1A1
2
Show member pathways
9.0NOS1, NGFR, GDNF
39.0NOS1, NGFR, GDNF

Compounds for genes affiliated with Pyloric Stenosis

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Pyloric Stenosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin4610.1HMOX2, NOS1
2mptp469.9NOS1, GDNF
3capsaicin46 3010.9NOS1, GDNF
4peroxynitrite469.7NGFR, NOS1
5guanylate469.6HMOX2, NOS1
6hematoxylin469.6DES, NGFR
7imipramine46 30 52 25 1213.6UGT1A1, NOS1
8dbc-amp469.5NGFR, GDNF
9norepinephrine46 25 1211.4NOS1, GDNF, DES
10choline46 25 1211.4GDNF, NGFR, NOS1
11creatinine469.4NOS1, GDNF, DES
12nadph46 2510.4NGFR, HMOX2, NOS1
13gaba469.4NGFR, NOS1, GDNF
14hydroxyurea46 52 1211.3UGT1A1, NOS1
15actinomycin d469.3DES, GDNF, HMOX2
16nmda46 3010.3NGFR, GDNF, NOS1
17iron46 2510.3HMOX2, DES, GDNF
18adenylate469.3GDNF, DES, NOS1
19ibuprofen46 30 52 25 1213.3NGFR, UGT1A1
20ganglioside469.2NGFR, DES, GDNF
21catecholamine469.2NGFR, GDNF
22h2o2469.2NOS1, DES, GDNF
23ethanol46 52 25 1212.2GDNF, NGFR, DES
24genistein46 30 62 3 25 1214.1GDNF, NOS1, UGT1A1
25nicotine46 30 52 1212.1UGT1A1, NOS1, NGFR
26aspartate469.1GDNF, NOS1, UGT1A1
27indomethacin46 30 62 1212.0NGFR, NOS1, UGT1A1
28cyclic amp46 2510.0GDNF, NGFR, DES
29morphine46 52 30 1212.0UGT1A1, NOS1
30dopamine46 30 25 1211.9GDNF, NGFR, HMOX2, NOS1
31superoxide46 259.9NGFR, NOS1, HMOX2, GDNF
32glutamate468.9GDNF, HMOX2, NOS1, NGFR
33testosterone46 62 25 1211.9UGT1A1, NOS1, DES
34vegf468.8GDNF, NOS1, DES, NGFR
35thymidine46 259.8NGFR, UGT1A1, DES
36cysteine468.8NOS1, GDNF, DES, NGFR
37glucose468.7NGFR, GDNF, HMOX2, DES
38arginine468.7HMOX2, DES, NOS1, UGT1A1
39dexamethasone46 52 30 1211.6NOS1, GDNF, NGFR, UGT1A1
40steroid468.5UGT1A1, NGFR, DES
41progesterone46 30 62 25 1212.5DES, UGT1A1, NGFR, HMOX2
42serine468.4NKX2-5, NGFR, DES, GDNF, NOS1
43acetylcholine46 52 30 25 1212.4HMOX2, NOS1, NGFR, GDNF, DES
44oxygen46 259.4GDNF, DES, NGFR, HMOX2, NOS1
45calcium46 52 25 1211.4GDNF, NOS1, HMOX2, DES, NGFR
46retinoic acid46 259.1GDNF, DES, UGT1A1, NOS1, NGFR
47nitric oxide46 25 1210.0NKX2-5, GDNF, NOS1, HMOX2, DES, NGFR
48tyrosine468.0NGFR, HMOX2, GDNF, UGT1A1, DES
49estrogen467.6UGT1A1, DES, GDNF, HMOX2, NOS1, NGFR

GO Terms for genes affiliated with Pyloric Stenosis

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17Gene Ontology
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Cellular components related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.6NOS1, DES

Biological processes related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle contractionGO:0551179.7NKX2-5, NOS1
2heme catabolic processGO:0421679.3HMOX2, UGT1A1
3positive regulation of transcription from RNA polymerase II promoterGO:0459449.2NOS1, NKX2-5, GDNF
4porphyrin-containing compound metabolic processGO:0067789.1HMOX2, UGT1A1
5negative regulation of apoptotic processGO:0430668.6NGFR, NKX2-5, GDNF

Molecular functions related to Pyloric Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.7NKX2-5, UGT1A1, GDNF

Products for genes affiliated with Pyloric Stenosis

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  • Antibodies
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Sources for Pyloric Stenosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet