Aliases & Classifications for Pyoderma

Summaries for Pyoderma

Disease Ontology : 12 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

MalaCards based summary : Pyoderma is related to pyoderma gangrenosum and collagenous colitis, and has symptoms including exanthema, pruritus and pustular rash. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and neutrophil, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial... more...

Related Diseases for Pyoderma

Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
id Related Disease Score Top Affiliating Genes
1 pyoderma gangrenosum 33.8 CXCL8 F3 TNF
2 collagenous colitis 29.5 CXCL8 NOD2 TNF
3 burns 29.4 CXCL8 MMP9 TNF
4 myiasis 29.3 CXCL8 MEFV TNF
5 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.0
6 pyogenic arthritis, pyoderma gangrenosum and acne 12.0
7 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 11.7
8 crohn's disease 11.1
9 impetigo 11.1
10 actinic prurigo polymorphic light eruption, hereditary 10.9
11 polydactyly, postaxial, types a1 and b 10.8
12 ileocolitis 10.8
13 cutaneous diphtheria 10.8
14 radial ray agenesis 10.3 IL1R1 PSTPIP1
15 nemaline myopathy 1, autosomal dominant or recessive 10.3 PSTPIP1 TNF
16 dermatosis papulosa nigra 10.2 NOD2 TNF
17 conidiobolomycosis 10.2 CXCL8 TNF
18 myeloid neoplasms associated with pdgfrb rearrangement 10.2 MEFV TNF
19 tau syndrome 10.2 MEFV TNF
20 thymic neuroendocrine carcinoma 10.2 CXCL8 TNF
21 candidiasis, familial, 4, autosomal recessive 10.2 MEFV TNF
22 colitis 10.2
23 coronary arterial fistulas 10.2 CXCL8 NOD2
24 amyotrophic lateral sclerosis type 5 10.2 NOD2 TNF
25 senile reticular retinal degeneration 10.2 CXCL8 IL1R1 TNF
26 muckle-wells syndrome 10.2 IL1R1 MEFV
27 ulcerative colitis 10.2
28 functional gastric disease 10.2 IL1R1 NOD2 TNF
29 amyotrophic lateral sclerosis type 14 10.2 CXCL8 NOD2 TNF
30 bare lymphocyte syndrome, type i 10.2 CXCL8 IL1R1 TNF
31 parkinson disease 11 10.2 CXCL8 NOD2 TNF
32 warthin tumor 10.2 IL1R1 TNF
33 pyloric stenosis, infantile hypertrophic, 2 10.2 MEFV PSTPIP1 TNF
34 benign neonatal seizures 10.2 IL1R1 MEFV TNF
35 patellar tendinitis 10.2 CXCL8 IFNA2 IL1R1
36 pulmonary artery coming from the aorta 10.2 MEFV NOD2 PSTPIP1
37 benign eccrine breast spiradenoma 10.2 CXCL8 NOD2 TNF
38 wilkes stevenson syndrome 10.1 CXCL8 IL1R1 MEFV
39 uterine ligament clear cell adenocarcinoma 10.1 CXCL8 NOD2 TNF
40 strawberry gallbladder 10.1 CXCL8 MEFV TNF
41 meier-gorlin syndrome 3 10.1 MEFV NOD2 TNF
42 major depressive disorder and accelerated response to antidepressant drug treatment 10.1 CXCL8 ITGB2 TNF
43 esotropia 10.1 IFNA2 ITGB2 MEFV
44 childhood malignant hemangiopericytoma 10.1 CXCL8 NOD2 TNF
45 acute gonococcal cystitis 10.1 CXCL8 NOD2
46 senile cataract 10.1 IFNA2 MEFV TNF
47 acne 10.1
48 acute kidney failure 10.1 CXCL8 ITGB2 PSTPIP1 TNF
49 tetanus 10.1 MEFV TNF
50 inflammatory bowel disease 10.1

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma

Symptoms & Phenotypes for Pyoderma

UMLS symptoms related to Pyoderma:


exanthema, pruritus, pustular rash

MGI Mouse Phenotypes related to Pyoderma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 TNF BTK F3 IL1R1 ITGB2 MEFV
2 immune system MP:0005387 9.65 BTK F3 IL1R1 ITGB2 MEFV MMP10
3 integument MP:0010771 9.17 BTK F3 IL1R1 ITGB2 MEFV MMP9

Drugs & Therapeutics for Pyoderma

Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 3
2 Anti-Infective Agents Phase 4,Phase 3
3
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
4 Pharmaceutical Solutions Phase 3,Phase 2
5
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
6 Antibodies Phase 2,Phase 1
7 Antibodies, Monoclonal Phase 2,Phase 1
8 Immunoglobulins Phase 2,Phase 1
9 Calcineurin Inhibitors Phase 2
10 Immunosuppressive Agents Phase 2
11 Dermatologic Agents Phase 2
12 Antirheumatic Agents Phase 2
13
Infliximab Approved 170277-31-3
14
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
15 Gastrointestinal Agents
16 Vaccines
17 Amoxicillin-Potassium Clavulanate Combination
18 beta-Lactamase Inhibitors
19 Clavulanic Acid

Interventional clinical trials:

(show all 24)
id Name Status NCT ID Phase
1 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas (Study P04460) Withdrawn NCT00202891 Phase 4
2 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3
3 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3
4 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3
5 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3
6 Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum Completed NCT01882504 Phase 2
7 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
8 Canakinumab for Pyoderma Gangrenosum Completed NCT01302795 Phase 2
9 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2
10 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Recruiting NCT03137160 Phase 2
11 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2
12 Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum Recruiting NCT03072953 Phase 2
13 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Recruiting NCT02902822 Phase 2
14 Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2
15 Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00690846 Phase 2
16 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Unknown status NCT00933296
17 Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease Completed NCT00791557
18 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
19 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
20 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
21 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
22 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275
23 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
24 A Real World, Observational Registry of Chronic Wounds and Ulcers Recruiting NCT02280733

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

MalaCards organs/tissues related to Pyoderma:

39
Skin, Breast, Neutrophil, T Cells, Myeloid, Lung, Bone

Publications for Pyoderma

Articles related to Pyoderma:

(show top 50) (show all 835)
id Title Authors Year
1
Establishing a canine superficial pyoderma model. ( 27891724 )
2017
2
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
3
Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis. ( 27384061 )
2016
4
Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. ( 27617462 )
2016
5
Pyoderma gangrenosum and necrotizing fasciitis-like opportunistic invasive cutaneous fungal infection. ( 27126743 )
2016
6
Pyoderma Vegetans Misdiagnosed as Verrucous Carcinoma. ( 26825160 )
2016
7
Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I. ( 27219252 )
2016
8
Clinical features, causes, treatments, and outcomes of peristomal pyoderma gangrenosum (PPG) in 44 patients: The Mayo Clinic experience, 1996 through 2013. ( 27473454 )
2016
9
Biologics for the treatment of pyoderma gangrenosum in ulcerative colitis. ( 27799888 )
2016
10
Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases. ( 28025853 )
2016
11
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
12
Pediatric pyoderma gangrenosum: is it just big wounds on little adults? ( 27916349 )
2016
13
High level of serum human interleukin-18 in a patient with pyogenic arthritis, pyoderma gangrenosum and acne syndrome. ( 27505688 )
2016
14
Pyoderma gangrenosum of the eyelid. ( 27085278 )
2016
15
Postoperative Pyoderma Gangrenosum: AA Clinical Review of Published Cases. ( 27489052 )
2016
16
Gene Therapy for Pyoderma Gangrenosum: Optimal Transfection Conditions and Effect of Drugs on Gene Delivery in the HaCaT Cell Line Using Cationic Liposomes. ( 27159975 )
2016
17
Post Surgical Pyoderma Gangrenosum in flap surgery: diagnostic clues and treatment recommendations. ( 27938245 )
2016
18
Pyoderma gangrenosum with extensive pulmonary involvement. ( 27658239 )
2016
19
Pyoderma gangrenosum and its syndromic forms: Evidence for a link with autoinflammation. ( 27106250 )
2016
20
Successful Treatment of Pyoderma Gangrenosum after Augmentation Mastopexy Using Vacuum Therapy. ( 27975008 )
2016
21
Severe pyoderma gangrenosum in association with a flame burn. ( 27583260 )
2016
22
Intralesional methotrexate as an adjuvant treatment for pyoderma gangrenosum: A case report. ( 27451930 )
2016
23
Cutaneous Angiosarcoma Simulating as Pyoderma in a Middle-aged Indian female: A Rare Case Report. ( 27904196 )
2016
24
Severe Bilateral Lower Extremity Pyoderma Gangrenosum. ( 27980702 )
2016
25
Superficial granulomatous pyoderma: A great mimicker. ( 28004648 )
2016
26
Pyoderma gangrenosum after trauma in a dog. ( 27108868 )
2016
27
Successful Treatment of Pyoderma Gangrenosum with Cryoglobulinemia and Hepatitis C. ( 27345376 )
2016
28
Delayed diagnosis of bullous pyoderma gangrenosum with acute myelogenous leukemia. ( 27811462 )
2016
29
Autoinflammation in pyoderma gangrenosum and its syndromic form PASH. ( 27943240 )
2016
30
Streptococcal Immunity Is Constrained by Lack of Immunological Memory following a Single Episode of Pyoderma. ( 28027314 )
2016
31
Pyoderma gangrenosum associated with mantle cell lymphoma. ( 27559522 )
2016
32
Pyoderma gangrenosum mimicking mediastinitis after cardiac surgery: a case study. ( 27286670 )
2016
33
Treatment of pyoderma gangrenosum with thalidomide in a myelodysplastic syndrome case. ( 27051318 )
2016
34
Bullous Pyoderma Gangrenosum With Subungual Involvement Associated With Ulcerative Colitis. ( 27893467 )
2016
35
Unusual cause of breast wound: postoperative pyoderma gangrenosum. ( 27444684 )
2016
36
High-dose ustekinumab for the treatment of severe, recalcitrant pyoderma gangrenosum. ( 27502191 )
2016
37
Pyoderma gangrenosum: A clinico-epidemiological study. ( 27549869 )
2016
38
Antimicrobial resistance, integron carriage, and gyrA and gyrB mutations in Pseudomonas aeruginosa isolated from dogs with otitis externa and pyoderma in Brazil. ( 26833540 )
2016
39
Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum. ( 27864925 )
2016
40
Hyperbaric Oxygen Therapy for the Adjunctive Treatment of Pyoderma Gangrenosum: A Case Report. ( 27192719 )
2016
41
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years. ( 26776602 )
2016
42
Successful treatment of large refractory pyoderma gangrenosum-like presentation of granulomatosis with polyangiitis with rituximab. ( 27126548 )
2016
43
Concomitant Pyoderma Gangrenosum and Erythema Nodosum in a Patient With Ulcerative Colitis. ( 27474109 )
2016
44
Ocular pyoderma gangrenosum: A systematic review. ( 27836332 )
2016
45
Pyoderma Gangrenosum-A New Manifestation of Wilson Disease? ( 27194899 )
2016
46
Pyoderma Gangrenosum in the Urologist Clinic. ( 27867335 )
2016
47
The diagnosis you wish you had never operated on: Pyoderma gangrenosum misdiagnosed as necrotizing fasciitis-a case report. ( 27875063 )
2016
48
Pyoderma gangrenosum associated with alitretinoin therapy. ( 27051854 )
2016
49
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. ( 27524799 )
2016
50
Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum. ( 27585859 )
2016

Variations for Pyoderma

Expression for Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for Pyoderma

Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 BTK C7 CXCL8 IFNA2 IL1R1 ITGB2
2
Show member pathways
13.06 CXCL8 IFNA2 IL1R1 ITGB2 MMP9 NOD2
3
Show member pathways
12.74 BTK CXCL8 IFNA2 MMP9 TNF
4
Show member pathways
12.13 CXCL8 IL1R1 TNF
5
Show member pathways
12.11 BTK CXCL8 F3 IFNA2 IL1R1 MEFV
6
Show member pathways
12.05 CXCL8 IL1R1 TNF
7
Show member pathways
12.01 CXCL8 IFNA2 TNF
8 11.99 IFNA2 ITGB2 NOD2 TNF
9 11.96 C7 F3 ITGB2
10 11.96 IL1R1 MMP9 TNF
11 11.92 CXCL8 IFNA2 TNF
12 11.9 BTK IL1R1 TNF
13
Show member pathways
11.85 MEFV NOD2 PSTPIP1
14 11.82 F3 ITGB2 MMP9
15 11.81 MMP9 NOD2 TNF
16 11.76 CXCL8 F3 TNF
17
Show member pathways
11.76 MMP10 MMP9 TNF
18 11.75 CXCL8 IL1R1 MMP9 TNF
19 11.71 CXCL8 ITGB2 TNF
20 11.68 CXCL8 ITGB2 MMP9 TNF
21 11.61 CXCL8 ITGB2 TNF
22 11.54 CXCL8 IL1R1 ITGB2 TNF
23 11.52 CXCL8 MMP9 TNF
24
Show member pathways
11.51 CXCL8 MMP9 TNF
25 11.49 CXCL8 MMP10 MMP9
26 11.43 CXCL8 ITGB2 TNF
27 11.43 BTK CXCL8 IL1R1 TNF
28 11.36 CXCL8 IL1R1 TNF
29 11.34 CXCL8 ITGB2 TNF
30 11.31 ITGB2 MMP9 TNF
31 11.05 IL1R1 MMP9
32 11.03 CXCL8 TNF
33 11.01 NOD2 TNF
34 10.91 CXCL8 TNF

GO Terms for Pyoderma

Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CXCL8 F3 IFNA2 MMP10 MMP9 TNF
2 extracellular region GO:0005576 9.56 C7 CXCL8 F3 IFNA2 IL1R1 MMP10
3 cell surface GO:0009986 9.02 F3 IL1R1 ITGB2 NOD2 TNF

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 BTK MEFV NOD2 PSTPIP1
2 cytokine-mediated signaling pathway GO:0019221 9.65 F3 IFNA2 IL1R1
3 defense response GO:0006952 9.56 CXCL8 IFNA2 NOD2 TNF
4 positive regulation of angiogenesis GO:0045766 9.54 CXCL8 F3 ITGB2
5 positive regulation of interleukin-8 production GO:0032757 9.51 NOD2 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.46 NOD2 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.46 BTK ITGB2 NOD2 TNF
8 embryonic digestive tract development GO:0048566 9.43 CXCL8 TNF
9 innate immune response GO:0045087 9.43 BTK C7 IFNA2 MEFV NOD2 PSTPIP1
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP9 TNF
11 cellular extravasation GO:0045123 9.32 ITGB2 TNF
12 inflammatory response GO:0006954 9.1 CXCL8 IFNA2 ITGB2 MEFV PSTPIP1 TNF

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 F3 IL1R1 TNF

Sources for Pyoderma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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