MCID: PYD002
MIFTS: 51

Pyoderma malady

Skin diseases category
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Summaries for Pyoderma

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Wikipedia:65 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as... more...

MalaCards based summary: Pyoderma is related to pyoderma gangrenosum and colitis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Signaling by Interleukins and Interleukin-1 signaling. The compounds methotrexate and il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are liver/biliary system and skeleton.

Disease Ontology:8 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

Aliases & Classifications for Pyoderma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Pyoderma, Aliases & Descriptions:

Name: Pyoderma 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:4223
MeSH34 D011711
ICD9CM27 686.00, 686.0
ICD1025 L08.0

Related Diseases for Pyoderma

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Diseases related to Pyoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum30.9MVK, MEFV, PSTPIP1, NLRP3, NOD2
2colitis30.8IL1R1, NOD2
3inflammatory bowel disease30.5IL1R1, PSTPIP1, NOD2
4ulcerative colitis30.5NOD2, IL1R1
5dermatitis30.1NOD2, NLRP3
6rheumatoid arthritis29.9IL1R1, MEFV, NOD2
7cataract29.7IL1R1, MVK
8arthritis29.5IL1R1, MVK, MEFV, PSTPIP1, NOD2, NLRP3
9acne10.5
10pyogenic arthritis, pyoderma gangrenosum and acne10.5
11crohn's disease10.5
12blastomycosis10.4
13myelodysplastic syndromes10.4
14hidradenitis10.3
15vasculitis10.3
16breast reconstruction10.3
17hidradenitis suppurativa10.2
18subcorneal pustular dermatosis10.2
19pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
20hepatitis10.2
21leukemia10.2
22takayasu's arteritis10.2
23ecthyma10.2
24myeloma10.2
25psoriasis10.2
26periodic fever, familial, autosomal dominant10.2MVK, MEFV
27relapsing fever10.2MEFV, MVK
28systemic lupus erythematosus10.2
29necrotizing fasciitis10.2
30collagenous colitis10.2
31agammaglobulinemia10.2
32fasciitis10.2
33lupus erythematosus10.2
34scabies10.2
35familial mediterranean fever10.1MEFV, NLRP3
36rheumatic disease10.1MEFV, IL1R1
37berger disease10.1IL1R1, MEFV
38aseptic meningitis10.1IL1R1, NLRP3
39autoimmune hepatitis10.1
40behcet's disease10.1
41relapsing polychondritis10.1
42sporotrichosis10.1
43leukocyte adhesion deficiency10.1
44folliculitis10.1
45osteomyelitis10.1
46otitis externa10.1
47chronic recurrent multifocal osteomyelitis10.1
48erythema elevatum diutinum10.1
49burns10.0
50chronic myelomonocytic leukemia10.0

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to pyoderma

Symptoms for Pyoderma

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Drugs & Therapeutics for Pyoderma

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Drug clinical trials:

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Search NIH Clinical Center for Pyoderma

Genetic Tests for Pyoderma

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Anatomical Context for Pyoderma

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MalaCards organs/tissues related to Pyoderma:

32
Skin, Breast, T cells, Neutrophil, Myeloid, Bone, Lung, Bone marrow, Monocytes, Heart, Liver, Prostate, Testes, Endothelial

Animal Models for Pyoderma or affiliated genes

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MGI Mouse Phenotypes related to Pyoderma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6IL1R1, NLRP3, MEFV
2MP:00053908.1NOD2, NLRP3, IL1R1, MEFV
3MP:00053788.1NOD2, NLRP3, IL1R1, MEFV
4MP:00053848.0NOD2, MEFV, IL1R1, NLRP3
5MP:00053977.8NOD2, PSTPIP1, MEFV, IL1R1, NLRP3
6MP:00053877.7NLRP3, IL1R1, MEFV, PSTPIP1, NOD2

Publications for Pyoderma

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Articles related to Pyoderma:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
The Genetics of Pyoderma Gangrenosum and Implications for Treatment: A Systematic Review. (25350484)
2014
2
Recurrent pyoderma gangrenosum after cesarean delivery successfully treated with vacuum-assisted closure and split thickness skin graft: A case report. (25370183)
2014
3
Pyoderma gangrenosum with renal and splenic impairment - case report. (24346905)
2013
4
Penile pyoderma gangrenosum. (24339469)
2013
5
Letter to the editor: Temporary renal insufficiency associated with topical tacrolimus treatment of multilocal pyoderma gangrenosum. (24133568)
2013
6
Pyoderma gangrenosum in a newborn - case report. (24346911)
2013
7
Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma. (23331693)
2013
8
Dermacase. Can you identify this condition? Pyoderma gangrenosum. (23585606)
2013
9
Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications. (23661290)
2013
10
Auricular pyoderma gangrenosum associated with Crohn's disease. (22585655)
2012
11
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
12
Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab. (22301049)
2012
13
Superficial granulomatous pyoderma of the face: a case report and review of the literature. (23308303)
2012
14
Nasal carriage of Staphylococcus schleiferi from healthy dogs and dogs with otitis, pyoderma or both. (22771206)
2012
15
Pyoderma gangrenosum in breast reconstruction. (22747349)
2012
16
Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China. (22229826)
2012
17
Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. (22534879)
2012
18
Penile pyoderma gangrenosum successfully treated with topical Imiquimod. (22021975)
2011
19
Staged correction of an equinovarus deformity due to pyoderma gangrenosum using a Taylor spatial frame and tibiotalar calcaneal fusion with an intramedullary device. (21863298)
2011
20
Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum. (22281912)
2011
21
Pyoderma gangrenosum following trauma of the knee: a case of pathergy and review of orthopaedic cases. (20638661)
2011
22
Tattoo related pyoderma/ectyma gangrenous as presenting feature of relapsed acute myeloid leukaemia: an exceptionally rare observation. (20883993)
2011
23
Ciprofloxacin induced pyoderma gangrenosum. (23130244)
2011
24
Pyoderma gangrenosum of the breast after bilateral simple mastectomies for ductal carcinoma in situ. (21944335)
2011
25
Beclometasone inhaler used to treat pyoderma gangrenosum. (20500206)
2010
26
Superficial granulomatous pyoderma: a case in an 11-year-old girl and review of the literature. (21182640)
2010
27
A case of pyoderma gangrenosum with ulcerative colitis treated with mesalazine. (21165212)
2010
28
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. (19673875)
2009
29
Adalimumab treatment for peristomal pyoderma gangrenosum associated with Crohn's disease. (18942748)
2009
30
Early diagnosis and early corticosteroid administration improves healing of peristomal pyoderma gangrenosum in inflammatory bowel disease. (19279428)
2009
31
Seat belt pyoderma gangrenosum: minor pressure as a causative factor. (18837131)
2008
32
Pyoderma gangrenosum of the scalp following hair highlights in a postpartum patient. (18086612)
2008
33
An open-label pilot study of alefacept for the treatment of pyoderma gangrenosum. (18384543)
2008
34
A novel therapy for the treatment of pyoderma gangrenosum. (18935734)
2008
35
Pyoderma gangrenosum in the head and neck. (17224531)
2007
36
Negative pressure dressing in the management of pyoderma gangrenosum ulcer. (17938337)
2007
37
Pulmonary manifestations of Pyoderma gangrenosum. (17555913)
2007
38
Pyoderma gangrenosum in an infant. (16918628)
2006
39
The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum. (16415387)
2006
40
A case of pyoderma gangrenosum responding to high-dose intravenous immunoglobulin therapy. (16863619)
2006
41
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. (17047113)
2006
42
Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis. (16428159)
2005
43
Small joint monoarthritis and pyoderma gangrenosum in newly diagnosed ulcerative colitis: an unusual presentation. (17043551)
2004
44
Pyoderma gangrenosum complicated by ecthyma gangrenosum. (15149521)
2004
45
Pyoderma and scabies: a benign association? (12734437)
2003
46
A case of SAPHO syndrome with pyoderma gangrenosum and inflammatory bowel disease masquerading as BehAset's disease. (12918720)
2003
47
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. (9212761)
1997
48
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
49
Klippel-Trenaunay-Weber syndrome mimicking pyoderma gangrenosum. (8537163)
1995
50
Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases. (1572226)
1992

Variations for Pyoderma

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Expression for genes affiliated with Pyoderma

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Expression patterns in normal tissues for genes affiliated with Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for genes affiliated with Pyoderma

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Compounds for genes affiliated with Pyoderma

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Sources:
50PharmGKB, 44Novoseek, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Pyoderma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1methotrexate50 44 1111.3NLRP3, IL1R1
2il 10449.2IL1R1, NOD2
3infliximab44 50 1111.2NOD2, IL1R1
4peptidoglycan44 2810.1NOD2, IL1R1
5mevalonate449.1NLRP3, MVK, MEFV
6anakinra44 1110.0NLRP3, IL1R1, MVK
7endotoxin448.9MEFV, IL1R1, NOD2
8prednisolone44 28 1110.8NOD2, IL1R1
9threonine448.1NOD2, NLRP3, IL1R1, MVK
10serine448.1PSTPIP1, MVK, IL1R1, NOD2

GO Terms for genes affiliated with Pyoderma

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Cellular components related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.6NOD2, NLRP3, MVK, MEFV, PSTPIP1

Biological processes related to Pyoderma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:0326959.4NOD2, MEFV
2detection of biotic stimulusGO:0095959.3NLRP3, NOD2
3positive regulation of interleukin-1 beta secretionGO:0507189.2NLRP3, NOD2
4regulation of inflammatory responseGO:0507279.1IL1R1, NOD2
5negative regulation of inflammatory responseGO:0507289.1NLRP3, MVK, MEFV
6inflammatory responseGO:0069549.1NLRP3, MEFV, PSTPIP1
7protein oligomerizationGO:0512599.1NOD2, NLRP3
8positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, NLRP3
9defense responseGO:0069528.9NOD2, NLRP3
10negative regulation of NF-kappaB transcription factor activityGO:0320888.7NOD2, NLRP3
11nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.4NOD2, NLRP3, MEFV, PSTPIP1
12innate immune responseGO:0450878.4NOD2, NLRP3, MEFV, PSTPIP1

Molecular functions related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.0NOD2, NLRP3

Products for genes affiliated with Pyoderma

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Sources for Pyoderma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet