MCID: PYD002
MIFTS: 49

Pyoderma malady

Skin diseases category

Summaries for Pyoderma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as... more...

MalaCards: Pyoderma is related to pyoderma gangrenosum and ulcerative colitis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and TRAF6 Mediated Induction of proinflammatory cytokines. The compounds anakinra and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are integument and immune system.

Disease Ontology:8 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

Aliases & Classifications for Pyoderma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pyoderma 8 44 60


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Disease Ontology8 DOID:4223
MeSH34 D011711
ICD9CM27 686.00, 686.0
ICD1025 L08.0

Related Diseases for Pyoderma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum31.7NLRP3, MVK, PSTPIP1, MEFV, MESDC1, NOD2
2ulcerative colitis30.8NOD2, IL1R1, PRTN3, ITGB2
3inflammatory bowel disease30.7NOD2, IL1R1, PRTN3, ITGB2, PSTPIP1
4arthritis30.6NLRP3, MVK, PSTPIP1, MEFV, ITGB2, PRTN3
5crohn's disease30.6NOD2
6vasculitis30.3PRTN3, ITGB2, MEFV, APOH
7rheumatoid arthritis30.2NOD2, IL1R1, BTK, PRTN3, ITGB2, MEFV
8dermatitis30.2NLRP3, ITGB2, NOD2
9leukemia30.2IDS, ITGB2, PRTN3, BTK, IL1R1
10psoriasis30.2ITGB2, IL1R1, NOD2, SERPINB13
11osteomyelitis30.1PSTPIP2
12lupus erythematosus30.0APOH
13systemic lupus erythematosus30.0APOH, ITGB2, PRTN3, IL1R1, NOD2
14sapho syndrome29.9PSTPIP2
15squamous cell carcinoma29.9ITGB2, PRTN3, IL1R1, MMP10, MMP26, SERPINB13
16pneumonia29.7BTK
17polyarteritis nodosa29.7MEFV, PRTN3
18conjunctivitis29.7NLRP3
19urticaria29.7ITGB2, NLRP3
20multiple sclerosis29.7ITGB2, IL1R1
21wegener's granulomatosis29.7PRTN3, ITGB2
22glomerulonephritis29.7IL1R1, PRTN3, ITGB2
23acne10.4
24blastomycosis10.4
25pyogenic arthritis, pyoderma gangrenosum and acne10.3
26hidradenitis10.3
27breast reconstruction10.2
28subcorneal pustular dermatosis10.2
29hidradenitis suppurativa10.2
30takayasu's arteritis10.2
31ecthyma10.2
32myeloma10.2
33pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
34agammaglobulinemia10.1
35cutaneous t cell lymphoma10.1
36hepatitis10.1
37scabies10.1
38antiphospholipid syndrome10.0
39relapsing polychondritis10.0
40folliculitis10.0
41leukocyte adhesion deficiency10.0
42necrotizing fasciitis10.0
43behcet's disease10.0
44sporotrichosis10.0
45acute leukemia10.0
46fasciitis10.0
47otitis externa10.0
48mevalonic aciduria10.0MVK
49spondylitis10.0NOD2
50amyloidosis10.0MEFV

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to pyoderma

Clinical Features for Pyoderma

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Drugs & Therapeutics for Pyoderma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pyoderma

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Anatomical Context for Pyoderma

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32MalaCards
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MalaCards organs/tissues related to Pyoderma:

32
Skin, Breast, T cells, Myeloid, Bone, Lung, Monocytes, Bone marrow, Prostate, Testes, Liver, Heart, Endothelial

Animal Models for Pyoderma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyoderma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2IDS, PSTPIP2, MEFV, ITGB2, BTK, IL1R1
2MP:00053878.2NOD2, NLRP3, IDS, PSTPIP1, PSTPIP2, MEFV

Publications for Pyoderma

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50PubMed
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Articles related to Pyoderma:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Concurrent hidradenitis suppurativa, inflammatory acne, dissecting cellulitis of the scalp, and pyoderma gangrenosum in a 16-year-old boy. (24118007)
2014
2
Pyoderma gangrenosum in a newborn - case report. (24346911)
2013
3
Pyoderma gangrenosum following foot and ankle surgery: a case report. (23637240)
2013
4
Pyoderma gangrenosum - a frequently misdiagnosed skin condition. (24033196)
2013
5
Refractory postsurgical pyoderma gangrenosum in a patient with Beckwith Wiedemann syndrome: response to multimodal therapy. (24154999)
2013
6
Pyoderma gangrenosum arising in a breast reduction scar: seven years post-procedure. (23759719)
2013
7
Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus. (23933249)
2013
8
Pyoderma gangrenosum with wrist joint destruction: case report. (23267758)
2013
9
Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum-like lesions. (23551965)
2013
10
Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab. (22301049)
2012
11
A mechanically powered negative pressure device used in conjunction with a bioengineered cell-based product for the treatment of pyoderma gangrenosum: a case report i>?. (22933700)
2012
12
Pyoderma gangrenosum, acne conglobata, suppurative hidradenitis, and axial spondyloarthritis: efficacy of anti-tumor necrosis factor I+ therapy. (23188209)
2012
13
Synchronous pyoderma gangrenosum and inflammatory bowel disease, healing after total proctocolectomy. (22892784)
2012
14
UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial. (22540770)
2012
15
Bullous pyoderma gangrenosum of the bilateral dorsal hands. (23039059)
2012
16
Pyoderma gangrenosum postlaparoscopy: a rare complication. (22318079)
2012
17
Clinical features and management of parastomal pyoderma gangrenosum in inflammatory bowel disease. (22584791)
2012
18
Photoletter to the editor: Oral ulceration in pyoderma gangrenosum. (21894254)
2011
19
Effectiveness of mycophenolic acid in refractory pyoderma gangrenosum. (20859217)
2010
20
Treatment of postsurgical pyoderma gangrenosum with a high-potency topical steroid. (20556729)
2010
21
Pyoderma gangrenosum: an updated review. (19470075)
2009
22
Pyoderma Gangrenosum in Crohn's Disease: Unusual Presentation and Management. (21103252)
2009
23
Pyoderma gangrenosum with myelodysplastic syndrome treated with analogous bone marrow transplantation. (19197560)
2009
24
Successful renal transplantation for a patient with pyoderma gangrenosum. (19249575)
2009
25
An unusual presentation of blastomycosislike pyoderma (pyoderma vegetans) and a review of the literature. (19911675)
2009
26
Pyoderma vegetans in a renal transplant recipient: first case of human infection with Nocardia vinacea. (19543072)
2009
27
Wegener's granulomatosis presenting as pyoderma gangrenosum. (18076660)
2008
28
Primary pyoderma gangrenosum of the lungs. (19119117)
2008
29
Multifocal papular deep bacterial pyoderma in a Boxer dog caused by Pseudomonas aeruginosa. (18959531)
2008
30
Leukocyte adsorption apheresis for the treatment of pyoderma gangrenosum. (19239562)
2008
31
Pyoderma gangrenosum after silicone prosthesis implant in the breasts and facial plastic surgery. (18289335)
2008
32
Negative pressure dressing in the management of pyoderma gangrenosum ulcer. (17938337)
2007
33
Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. (17306049)
2007
34
Blastomycosis-like pyoderma. (17456921)
2007
35
IgG multiple myeloma presented with ulcerative pyoderma gangrenosum. (17613774)
2007
36
Post-surgical pyoderma gangrenosum: a clinical entity. (17966539)
2007
37
Peristomal pyoderma gangrenosum associated with collagenous colitis. (17515527)
2007
38
Improvement of idiopathic pyoderma gangrenosum during treatment with anti-tumor necrosis factor alfa monoclonal antibody. (17558009)
2007
39
Recurrent postoperative pyoderma gangrenosum complicating pacemaker insertion. (16643154)
2006
40
BehAset's disease-like presentation of bullous pyoderma gangrenosum associated with Crohn's disease. (16681583)
2006
41
Pyoderma gangrenosum versus chronic venous ulceration: comparison of diagnostic features. (17241569)
2006
42
Pyoderma gangrenosum of the breasts precipitated by breast surgery. (16844520)
2006
43
Pyoderma gangrenosum complicated by ecthyma gangrenosum. (15149521)
2004
44
A case of SAPHO syndrome with pyoderma gangrenosum and inflammatory bowel disease masquerading as BehAset's disease. (12918720)
2003
45
Evaluation of in vitro activity of two topical products against three organisms isolated from canine referral patients with otitis externa and cutaneous pyoderma. (19757573)
2000
46
Pyoderma gangrenosum and extensive caval thrombosis associated with the antiphospholipid syndrome--a case report. (9482516)
1998
47
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. (9212761)
1997
48
Pyoderma gangrenosum in association with undifferentiated seronegative spondylarthropathy. (8651972)
1996
49
Unusual pyodermas (hidrosadenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp). (14826630)
1951
50
Necrobiosis lipoidica diabeticorum following pyoderma. (18208051)
1948

Genetic Variations for Pyoderma

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Expression for genes affiliated with Pyoderma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for genes affiliated with Pyoderma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Pathways related to Pyoderma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MEFV, PSTPIP1, NLRP3
2
Hide members
10.0NOD2, BTK, ITGB2
3
Hide members
9.9NOD2, MEFV, PSTPIP1, NLRP3
49.9SERPINB13, IL1R1, ITGB2
5
Hide members
9.8NLRP3, BTK, IL1R1, NOD2
6
Hide members
9.5NLRP3, PSTPIP1, MEFV, ITGB2, BTK, IL1R1

Compounds for genes affiliated with Pyoderma

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44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 28IUPHAR, 24HMDB
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Compounds related to Pyoderma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1anakinra44 1111.3IL1R1, MVK, NLRP3
2mevalonate4410.2NLRP3, MVK, MEFV, ITGB2
3hydroxychloroquine44 1111.1IL1R1, APOH
4infliximab44 49 1112.0NOD2, IL1R1, PRTN3, APOH
5ivig4410.0APOH, ITGB2, BTK, IL1R1
6rituximab44 49 1112.0IL1R1, PRTN3, APOH
7procainamide44 1111.0APOH, ITGB2
8propylthiouracil44 2 1112.0APOH
9prednisolone44 28 1112.0APOH, ITGB2, IL1R1, NOD2
10endotoxin449.9APOH, MEFV, ITGB2, IL1R1, NOD2
11gold449.8IL1R1, PRTN3, APOH
12fibrinogen449.7APOH, ITGB2, BTK, IL1R1, MMP26
13threonine449.7NLRP3, MVK, ITGB2, BTK, IL1R1, NOD2
14atp44 2810.6NLRP3, MVK, APOH, GUCA1A, ITGB2, BTK
15cysteine449.4IDS, GUCA1A, ITGB2, BTK, IL1R1, SERPINB13
16serine449.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
17calcium44 49 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, BTK

GO Terms for genes affiliated with Pyoderma

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16Gene Ontology
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Biological processes related to Pyoderma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.4NOD2, NLRP3
2negative regulation of interleukin-12 productionGO:03269510.3NOD2, MEFV
3negative regulation of inflammatory responseGO:05072810.2MEFV, MVK, NLRP3
4positive regulation of interleukin-1 beta secretionGO:05071810.2NOD2, NLRP3
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.1NOD2, MEFV, PSTPIP1, NLRP3
6toll-like receptor 4 signaling pathwayGO:03414210.0NOD2, BTK, ITGB2
7collagen catabolic processGO:03057410.0PRTN3, MMP10, MMP26
8positive regulation of NF-kappaB transcription factor activityGO:0510929.9NLRP3, BTK, NOD2
9toll-like receptor signaling pathwayGO:0022249.7ITGB2, BTK, NOD2
10innate immune responseGO:0450879.6NLRP3, PSTPIP1, MEFV, ITGB2, BTK, NOD2

Molecular functions related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma

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  • Antibodies
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Sources for Pyoderma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet