Pyoderma malady

Wikipedia: Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as...⁴⁴ more...

MalaCards: Pyoderma is related to pyogenic arthritis, pyoderma gangrenosum and acne and arthritis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Immune System. The compounds ivig and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin and monocytes, and related mouse phenotypes are hematopoietic system and skeleton.

Disease Ontology: Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.⁶

Aliases & Descriptions:

pyoderma 6 8 32 43

Diseases related to pyoderma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 524)

id	Related Disease	Score	Top Affiliating Genes
1	pyogenic arthritis, pyoderma gangrenosum and acne	31.5	MEFV, PTPN18, PSTPIP1
2	arthritis	29.2	IL6, IL8, TNF
3	acne	28.2	MMP1, IL1R1, IL8, IFNA2, TNF, NOD2
4	myelodysplastic syndrome	27.1	BTK, CD40LG, CD55, MEFV, IL6, IL8
5	agammaglobulinemia	27.0	BTK, CD40LG, IL6, TNF
6	antiphospholipid syndrome	27.0	CD40LG, APOH, F3, TNF
7	inflammatory bowel disease	26.2	CD55, ITGB2, MMP1, IL1R1, IL6, IL8
8	immunodeficiency	25.7	BTK, CD40LG, CD55, ITGB2, IL6, APOH
9	wegener's granulomatosis	25.6	ITGB2, IL6, IL8, APOH, F3, TNF
10	acquired immunodeficiency syndrome	25.4	CD40LG, IL6, APOH, IFNA2, F3, ALB
11	pyoderma gangrenosum	25.4	SERPINB13, MVK, CD40LG, CD55, ITGB2, MMP1
12	ulcerative colitis	25.1	CD55, ITGB2, MMP1, IL1R1, IL6, IL8
13	hodgkin's lymphoma	23.1	CD40LG, CD55, ITGB2, IL6, IL8, APOH
14	thrombosis	22.5	CD40LG, CD55, ITGB2, MMP1, MEFV, IL1R1
15	psoriasis	22.1	SERPINB13, CD40LG, CD55, ITGB2, MMP1, IL1R1
16	mevalonic aciduria	13.6	MVK, IDS, NLRP3
17	familial cold autoinflammatory syndrome	13.6	MEFV, IL1R1, NLRP3
18	cryopyrin-associated periodic syndrome	13.6	IL1R1, NLRP3
19	paralytic poliomyelitis	13.5	BTK, CD40LG
20	chronic infantile neurological cutaneous articular syndrome	13.5	MVK, MEFV, IL1R1, NLRP3
21	discoid lupus erythematosus of eyelid	13.4	APOH, IFNA2
22	degos disease	13.4	APOH, IFNA2
23	periodic fever, familial, autosomal dominant	13.4	MVK, MEFV, TNF
24	granulomatous dermatitis	13.4	TNF, NOD2
25	familial mediterranean fever	13.4	MEFV, TNF, NLRP3
26	mononeuropathy	13.3	APOH, IFNA2, PRTN3
27	catastrophic antiphospholipid syndrome	13.3	CD40LG, APOH, F3
28	sapho syndrome	13.3	TNF, NOD2, PSTPIP2
29	purpura fulminans	13.3	APOH, F3, CSF3
30	vulvar vestibulitis syndrome	13.3	IL1R1, TNF, NLRP3
31	hematuria	13.2	CD40LG, F3, PRTN3
32	erythema nodosum, idiopathic	13.2	TNF, NOD2
33	sycp3-related pregnancy loss, susceptibility to	13.2	CD40LG, APOH, F3
34	relapsing polychondritis	13.2	IL8, APOH, PRTN3
35	membranous glomerulonephritis	13.2	ITGB2, ALB
36	selective iga deficiency disease	13.2	BTK, CD40LG
37	erysipelas	13.2	CD40LG, MEFV, TNF
38	intestinal obstruction	13.2	MVK, ALB, NOD2
39	myelitis	13.2	CD40LG, IL6, APOH
40	muckle-wells syndrome	13.2	MEFV, IL1R1, IL8, NLRP3
41	wells syndrome	13.2	MEFV, IL1R1, IL8, NLRP3
42	nodular regenerative hyperplasia	13.2	IL6, APOH, F3
43	erythema elevatum diutinum	13.2	ITGB2, IL8
44	acquired von willebrand syndrome	13.1	CD40LG, F3
45	central nervous system disease	13.1	CD40LG, IL6, APOH
46	collagenous colitis	13.1	CD40LG, MMP1, APOH, NOD2
47	colchicine resistance	13.1	MEFV, IL1R1
48	mycobacterium marinum	13.1	IL8, TNF
49	peripheral vertigo	13.1	APOH, F3
50	fissured tongue	13.1	IL6, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pyoderma:

²²

MGI Mouse Phenotypes related to pyoderma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.5	CSF3, PSTPIP2, NOD2, MEFV, BTK
2	skeleton phenotype	MP:0005390	8.9	NOD2, IDS, IL6, IL1R1, MEFV, ITGB2
3	integument phenotype	MP:0010771	8.5	CSF3, PSTPIP2, NLRP3, F3, IDS, IL1R1
4	immune system phenotype	MP:0005387	8.3	BTK, PRTN3, PSTPIP1, PSTPIP2, NOD2, TNF
5	mortality/aging	MP:0010768	7.8	PSTPIP2, NLRP3, NOD2, F3, IDS, APOH

Articles related to pyoderma:

(show all 26)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in the PSTPIP1 gene and aberrant splicing v ariants in patients with pyoderma gangrenosum. (21790734)	Nesterovitch A.B.... Glant T.T.	2011	PSTPIP1
2	Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene. (21438098)	Lin Z.... Koltun W.A.	2011	PSTPIP1
3	Targeted treatment of pyoderma gangrenosum in PAPA (p yogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. (19673875)	Brenner M.... Herzer P.	2009	IL1R1
4	Reduction of interleukin-6, interleukin-8, and anti-p hosphatidylserine-prothrombin complex antibody by granulocyte and monocyte adso rption apheresis in a patient with pyoderma gangrenosum and ulcerative colitis. (19727102)	Kawakami T.... Soma Y.	2009	IL6, IL8
5	Pyogenic arthritis, pyoderma gangrenosum, and acne sy ndrome (PAPA syndrome): report of a sporadic case without an identifiable mutat ion in the CD2BP1 gene. (19700023)	Hong J.B.... Chiu H.C.	2009	PSTPIP1
6	Wegener's granulomatosis presenting as pyoderma gangrenosum. (18076660)	Boudny C.... Simon D.	2008	PRTN3
7	Blastomycosis-like pyoderma. (17456921)	Sawalka S.S.... Jerajani H.R.	2007	ALB
8	Pyoderma gangrenosum and exacerbation of psoriasis re sulting from pegylated interferon alpha and ribavirin treatment of chronic hepa titis C. (17700270)	Yurci A.... Yucesoy M.	2007	IFNA2
9	Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum. (18001410)	Bister V.... Saarialho-Kere U.	2007	MMP1, MMP10, MMP26
10	The role of anti-tumor necrosis factor-alpha therapy in Pyoderma gangrenosum associated with inflammatory bowel disease. (17428111)	ReguiaA^ Z.... Grange F.	2007	TNF
11	Successful treatment of myelodysplastic syndrome-indu ced pyoderma gangrenosum. (17179573)	Koca E.... Ozcebe O.I.	2006	IFNA2
12	Adalimumab therapy for recalcitrant pyoderma gangreno sum. (17149453)	Fonder M.A.... Meyerle J.H.	2006	TNF
13	De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. (16729790)	Lin M.T.... Yang H.C.	2006	BTK
14	Pyoderma gangrenosum complicating pegylated granulocyte colony-stimulating factor in Hodgkin lymphoma. (16371028)	Miall F.M.... Dyer M.J.	2006	CSF3
15	Pyoderma gangrenosum related to a new granulocyte col ony-stimulating factor. (16603845)	White L.E.... Medenica M.M.	2006	CSF3
16	Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome. (15916580)	Stichweh D.S.... Pascual V.	2005	PSTPIP1
17	Treatment of pyoderma gangrenosum with etanercept. (15303791)	McGowan J.W.... Lynn A.	2004	TNF
18	CD2BP1 and CARD15 mutations are not associated with pyoderma gangrenosum in patients with inflammatory bowel disease. (15102098)	Newman B.... Siminovitch K.A.	2004	NOD2, PSTPIP1
19	Pyoderma gangrenosum associated with paroxysmal nocturnal hemoglobulinuria and monoclonal gammopathy. (11890301)	Matsubara K.... Mizutani H.	2002	CD55
20	Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome. (11703524)	Laochumroonvorapong P.... Levy H.	2001	CD40LG
21	Pyoderma gangrenosum following cytosine arabinoside, aclarubicin and granulocyte colony-stimulating factor combination therapy in myelodysplastic syndrome. (9617871)	Takagi S.... Matsuoka T.	1998	CSF3
22	Pyoderma gangrenosum in a child with congenital partial deficiency of leucocyte adherence glycoproteins. (9990374)	Bedlow A.J.... Marsden R.A.	1998	ITGB2
23	Pyoderma gangrenosum and extensive caval thrombosis associated with the antiphospholipid syndrome--a case report. (9482516)	Chacek S.... QuiA+ones-Galvan A.	1998	F3, APOH
24	Bullous pyoderma gangrenosum in a patient with myelodysplastic syndrome during granulocyte colony-stimulating factor therapy. (9389372)	Lewerin C.... Swolin B.	1997	CSF3
25	Fatal pyoderma gangrenosum in association with C7 deficiency. (1517503)	Friduss S.R.... Fivenson D.P.	1992	C7
26	Bullous pyoderma gangrenosum after granulocyte colony-stimulating factor treatment. (1712666)	Ross H.J.... Figlin R.A.	1991	CSF3

Genes related to pyoderma according to GeneCards:

(show all 31)

id	Symbol	Description	Score	GeneCards Section Context
1	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	11.0	Publications
2	MVK	mevalonate kinase	11.0
3	MEFV	Mediterranean fever	11.0
4	NLRP3	NLR family, pyrin domain containing 3	11.0
5	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
6	MESDC1	mesoderm development candidate 1	11.0
7	MMP26	matrix metallopeptidase 26	11.0	Publications
8	PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	11.0
9	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
10	GUCA1A	guanylate cyclase activator 1A (retina)	11.0
11	IDS	iduronate 2-sulfatase	11.0
12	C7	complement component 7	11.0	Publications
13	PRTN3	proteinase 3	11.0	Publications
14	PSTPIP2	proline-serine-threonine phosphatase interacting protein 2	11.0
15	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0	Publications
16	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
17	IL1R1	interleukin 1 receptor, type I	11.0	Publications
18	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
19	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
20	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
21	CD40LG	CD40 ligand	11.0	Publications
22	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
23	IFNA2	interferon, alpha 2	11.0	Publications
24	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications
26	IL8	interleukin 8	11.0	Publications
27	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
28	MESDC2	mesoderm development candidate 2	11.0
29	SERPINB13	serpin peptidase inhibitor, clade B (ovalbumin), member 13	11.0
30	OR6B1	olfactory receptor, family 6, subfamily B, member 1	11.0	Disorders
31	ALB	albumin	11.0	Publications

Pathways related to pyoderma according to GeneDecks:

(show all 42)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.4	BTK, CSF3
2	Immune System38	10.2	PSTPIP1, NLRP3, IL1R1, MEFV
3	Immune response_Alternative complement pathway41	10.1	C7, ITGB2, CD55
4	Immune response Alternative complement pathway10	10.1	C7, ITGB2, CD55
5	Immune response_Lectin induced complement pathway41	10.0	C7, ITGB2, CD55
6	Inhibition of Matrix Metalloproteinases36	10.0	MMP1, MMP10, MMP26
7	Immune response Lectin Induced complement pathway10	10.0	C7, ITGB2, CD55
8	Immune response_Bacterial infections in normal airways41	9.9	IL1R1
9	PGC1Alpha Pathway36	9.8	IL8, IL1R1, BTK
10	Akt Signaling36	9.6	TNF, IL6, ITGB2, BTK
11	Cytokine production by Th17 cells in CF41	9.5	IL6, IL8, CSF3
12	Bacterial infections in CF airways41	9.4	IL1R1, IL6, IL8, TNF
13	Rho Family GTPases36	9.4	BTK, ITGB2, IL8, CSF3
14	Cytokine Network36	9.3	IL6, IL8, IFNA2, TNF
15	Immune response_MIF in innate immunity response41	9.3	TNF, IL8, IL6
16	Tuberculosis20	9.3	NOD2, TNF, IFNA2, IL6, ITGB2
17	Immune response_MIF-mediated glucocorticoid regulation41	9.3	TNF, IL8, IL6, MMP1
18	Immune response MIF-mediated glucocorticoid regulation10	9.3	TNF, IL8, IL6, MMP1
19	Pertussis20	9.3	NLRP3, TNF, IL8, IL6, ITGB2
20	Transendothelial Migration of Leukocytes36	9.3	IL8, MMP26, MMP10, MMP1, ITGB2, BTK
21	Hematopoietic cell lineage20	9.3	CSF3, TNF, IL6, IL1R1, CD55
22	Immune response MIF in innate immunity response10	9.2	TNF, IL8, IL6
23	Toll-like receptor signaling pathway20	9.2	TNF, IFNA2, IL8, IL6
24	Immune response IL-1 signaling pathway10	9.2	TNF, F3, IL8, IL6, IL1R1
25	Immune response_IL-1 signaling pathway41	9.2	TNF, F3, IL8, IL6, IL1R1
26	MIF Mediated Glucocorticoid Regulation36	9.1	CSF3, TNF, IL8, IL6, BTK
27	MIF Regulation of Innate Immune Cells36	9.1	CSF3, TNF, IL8, IL6, BTK
28	all-trans-Retinoic Acid Signaling in Brain36	9.1	CSF3, TNF, IL8, IL6, BTK
29	PEDF Induced Signaling36	9.1	BTK, IL6, IL8, TNF, CSF3
30	Influenza A20	9.1	NLRP3, TNF, IFNA2, IL8, IL6
31	NOD-like receptor signaling pathway20	9.1	MEFV, PSTPIP1, NLRP3, NOD2, TNF, IL8
32	IL-6 Pathway36	9.1	BTK, IL6, IL8, TNF, CSF3
33	Rheumatoid arthritis20	9.1	TNF, IL8, IL6, MMP1, ITGB2
34	Endothelin-1 Signaling Pathway36	9.0	CSF3, TNF, IL8, IL6, BTK
35	STAT3 Pathway36	8.9	CSF3, TNF, IL8, IL6, IL1R1, BTK
36	Malaria20	8.9	CSF3, TNF, IL8, IL6, ITGB2, CD40LG
37	Tec Kinases Signaling36	8.9	TNF, IL8, IL6, IL1R1, ITGB2, BTK
38	Antioxidant Action of Vitamin-C36	8.7	CSF3, TNF, IL8, IL6, IL1R1, BTK
39	p38 Signaling36	8.7	CSF3, TNF, IL8, IL6, IL1R1, BTK
40	Amoebiasis20	8.6	TNF, IL8, IL6, IL1R1, ITGB2, SERPINB13
41	Cytokine-cytokine receptor interaction20	8.6	CSF3, TNF, IFNA2, IL8, IL6, IL1R1
42	Molecular Mechanisms of Cancer36	8.2	CSF3, TNF, IL8, IL6, IL1R1, ITGB2

Compounds related to pyoderma according to GeneDecks:

(show top 50)    (show all 136)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.7	BTK
2	cyclophosphamide32 34 9 9	13.3	APOH, ITGB2
3	epinephrine32 9 18 9	13.2	MMP1, F3
4	hydroxychloroquine32 9 9	12.1	CD40LG, APOH, IL1R1
5	hyaluronic acid32 18	11.1	ITGB2, PRTN3, MMP1
6	rituximab32 34 9 9	12.9	CD55, PRTN3, IL1R1, CD40LG
7	n-formylmethionyl-leucylphenylalanine32	9.9	CD55, ITGB2, CSF3, PRTN3
8	endotoxin32	9.6	MEFV, IL1R1, APOH, F3, CSF3, ITGB2
9	anakinra32 9 9	11.6	NLRP3, IL6, IL1R1, MVK, TNF
10	aebsf32	9.5	IL8, F3, TNF, PRTN3
11	polysulfone32	9.4	ALB, IL1R1, ITGB2, F3
12	leflunomide32 9 9	11.2	MMP1, IL1R1, BTK, TNF, IL6
13	il 1032	9.2	IL1R1, NOD2, IL6, TNF, IL8
14	peptidoglycan32	9.2	IL1R1, IL6, IL8, TNF, NOD2
15	imiquimod32 42 9 9	12.1	IL6, IL8, IFNA2, TNF
16	il-1232	9.1	TNF, CD40LG, IL1R1, IL6, IL8
17	lipoteichoic acid32	9.1	IL1R1, APOH, TNF, IL6, IL8
18	thalidomide32 42 9 9	12.1	ITGB2, IL6, IFNA2, CD40LG, TNF
19	heparin32 9 18 9	12.1	ALB, F3, ITGB2, CD55
20	dextran sulfate32	9.1	CD40LG, ALB, F3, IL6, APOH
21	ccl332	9.0	IL6, IL8, TNF, CSF3, IL1R1
22	polymyxin b32	9.0	ITGB2, TNF, IL8, IL6
23	sb 20358032 42	10.0	TNF, ITGB2, IL1R1, BTK, MMP1, IL6
24	ibuprofen32 9 18 9	12.0	MMP1, IL1R1, IL6, F3, ALB
25	gm-csf32	9.0	CSF3, TNF, IL6, IL8
26	simvastatin32 34 42 9 18 9	13.9	ITGB2, TNF, MVK, F3, IL6, IL8
27	neopterin32	8.8	IFNA2, TNF, IL8, IL6, CD40LG, IL1R1
28	pdtc32	8.8	TNF, F3, IL8, MMP1, IL6
29	fmlp32	8.8	CD55, ITGB2, CSF3, PRTN3, TNF, IL8
30	pentoxifylline32 9 9	10.6	F3, MMP1, IL8, TNF, IL6, IL1R1
31	infliximab32 9 9	10.6	MMP1, PRTN3, IL1R1, APOH, IFNA2, TNF
32	herbimycin a32 42	9.6	MMP1, CD40LG, TNF, IL8, ITGB2, IL6
33	etanercept32 9 9	10.5	IL6, IFNA2, APOH, TNF, IL8, MMP1
34	methotrexate32 34 42 9 9	12.3	MMP1, CSF3, TNF, NLRP3, ALB, APOH
35	genistein32 9 18 9	11.3	BTK, CD40LG, ITGB2, IL6, IL8, MMP1
36	rantes32	8.3	IL8, IL6, IL1R1, MMP1, ITGB2, TNF
37	indomethacin32 9 9	10.1	TNF, CD40LG, ALB, IFNA2, IL6, MMP1
38	cyclosporin a32 42	9.0	CSF3, IL1R1, IL6, CD40LG, CD55, ITGB2
39	fibrinogen32	8.0	BTK, TNF, F3, APOH, IL6, IL1R1
40	cysteine32	7.9	BTK, CD40LG, CD55, MMP1, GUCA1A, IFNA2
41	creatinine32	7.9	ALB, F3, APOH, IL6, MMP1, ITGB2
42	cycloheximide32	7.8	IL8, PRTN3, CSF3, ITGB2, MMP1, IL1R1
43	prednisolone32 9 9	9.8	CSF3, APOH, NOD2, IFNA2, ALB, IL6
44	histamine32 18	8.8	ITGB2, ALB, IL6, CD40LG, TNF, IFNA2
45	lactate32	7.7	IL8, ALB, TNF, APOH, IL6, ITGB2
46	alanine32	7.7	IL1R1, IL6, IFNA2, F3, PRTN3, ITGB2
47	retinoic acid32 42 18	9.7	PRTN3, TNF, IL6, IFNA2, F3, IL1R1
48	dexamethasone32 42 34 9 9	11.3	CD40LG, CD55, ITGB2, MMP1, IL1R1, IL6
49	vegf32	7.0	CD40LG, IL8, CD55, MMP1, MMP10, IL6
50	serine32	6.9	F3, CD40LG, MVK, PRTN3, NOD2, TNF

Cellular components related to pyoderma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.2	CD40LG, TNF, ALB, F3, IFNA2, APOH

Biological processes related to pyoderma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	detection of biotic stimulus	GO:009595	10.3	NOD2, NLRP3
2	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.1	MEFV, NOD2, NLRP3, PSTPIP1
3	positive regulation of B cell activation	GO:050871	9.9	IL6, NOD2
4	collagen catabolic process	GO:030574	9.8	PRTN3, MMP26, MMP10, MMP1
5	regulation of immunoglobulin secretion	GO:051023	9.7	CD40LG, TNF
6	negative regulation of lipid storage	GO:010888	9.6	IL6, TNF
7	positive regulation of interleukin-6 production	GO:032755	9.6	NOD2, TNF, IL6
8	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.3	NLRP3, NOD2, TNF, IL6, BTK
9	calcium-mediated signaling	GO:019722	9.2	TNF, IL8, BTK
10	innate immune response	GO:045087	8.9	BTK, PSTPIP1, C7, NLRP3, NOD2, IFNA2
11	inflammatory response	GO:006954	8.4	NLRP3, TNF, IFNA2, IL8, IL6, MEFV

Molecular functions related to pyoderma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.8	CD40LG, IL6, IFNA2, TNF, CSF3