Aliases & Classifications for Pyoderma

MalaCards integrated aliases for Pyoderma:

Name: Pyoderma 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4223
ICD10 33 L08.0
ICD9CM 35 686.0 686.00
MeSH 42 D011711
UMLS 69 C0034212

Summaries for Pyoderma

Disease Ontology : 12 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

MalaCards based summary : Pyoderma is related to lymphoma and scabies, and has symptoms including exanthema, pruritus and pustular rash. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial... more...

Related Diseases for Pyoderma

Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.3 APOH MEFV TNF
2 scabies 30.1 CXCL8 MEFV TNF
3 ectropion 29.8 MMP1 MMP9
4 prostatitis 29.7 APOH IL1R1
5 collagenous colitis 29.7 APOH MMP9
6 microscopic colitis 29.3 CXCL8 NOD2 TNF
7 rheumatoid arthritis 29.1 CXCL8 IL1R1 ITGB2 MMP1 TNF
8 myopathy 22.8 APOH BTK CXCL8 IFNA2 IL1R1 ITGB2
9 pyoderma gangrenosum 12.5
10 pyogenic arthritis, pyoderma gangrenosum and acne 12.2
11 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.0
12 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 11.8
13 crohn's disease 11.1
14 gapo syndrome 11.1
15 impetigo 11.1
16 actinic prurigo 10.9
17 pyruvate kinase deficiency, liver type 10.8 IL1R1 PSTPIP1
18 ileocolitis 10.7
19 cutaneous diphtheria 10.7
20 corticosteroid-sensitive aseptic abscesses 10.7
21 tabatznik syndrome 10.7 MEFV TNF
22 craniometaphyseal dysplasia 10.7 MEFV TNF
23 walker dyson syndrome 10.7 IL1R1 TNF
24 basidiobolomycosis 10.7 CXCL8 TNF
25 spirillary rat-bite fever 10.7 CXCL8 TNF
26 familial cold-induced inflammatory syndrome 1 10.7 IL1R1 MEFV
27 tarsal tunnel syndrome 10.6 CXCL8 TNF
28 crohn's colitis 10.6 NOD2 TNF
29 neuromuscular disease 10.6 NOD2 TNF
30 halal setton wang syndrome 10.6 CXCL8 TNF
31 tetanus 10.6 MEFV TNF
32 mechanical lagophthalmos 10.6 MEFV TNF
33 pulmonary hypertension 10.6 MMP1 TNF
34 plantar wart 10.6 CXCL8 TNF
35 multiple sclerosis 5 10.5 MEFV TNF
36 familial mediterranean fever, ad 10.5 MEFV PSTPIP1 TNF
37 congenital insensitivity to pain with hyperhidrosis 10.5 CXCL8 NOD2
38 benign neonatal seizures 10.5 IL1R1 MEFV TNF
39 acute gonococcal cystitis 10.5 CXCL8 NOD2
40 senile reticular retinal degeneration 10.5 CXCL8 IL1R1 TNF
41 pasteurellosis 10.5 CXCL8 TNF
42 epulis 10.5 CXCL8 TNF
43 congenital nystagmus 10.5 IFNA2 MEFV TNF
44 ragweed sensitivity 10.5 CXCL8 IL1R1 TNF
45 louping ill 10.4 CXCL8 MEFV TNF
46 dentin caries 10.4 CXCL8 IFNA2 IL1R1
47 esophagus melanoma 10.4 CXCL8 MEFV TNF
48 mycobacterium kansasii 10.4 CXCL8 TNF
49 acute erythroid leukemia 10.4 CXCL8 IFNA2 PSTPIP1
50 whistling face syndrome, recessive form 10.4 CXCL8 IL1R1 MEFV

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma

Symptoms & Phenotypes for Pyoderma

UMLS symptoms related to Pyoderma:


exanthema, pruritus, pustular rash

MGI Mouse Phenotypes related to Pyoderma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 MMP9 NOD2 PSTPIP1 TNF BTK IL1R1
2 immune system MP:0005387 9.32 BTK IL1R1 ITGB2 MEFV MMP1 MMP10

Drugs & Therapeutics for Pyoderma

Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 3
2 Anti-Infective Agents Phase 4,Phase 3
3
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
4 Pharmaceutical Solutions Phase 3,Phase 2
5
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
6 Antibodies Phase 2,Phase 1
7 Antibodies, Monoclonal Phase 2,Phase 1
8 Immunoglobulins Phase 2,Phase 1
9 Calcineurin Inhibitors Phase 2
10 Immunosuppressive Agents Phase 2
11 Dermatologic Agents Phase 2
12 Antirheumatic Agents Phase 2
13
Infliximab Approved 170277-31-3
14
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
15 Gastrointestinal Agents
16 Vaccines
17 Amoxicillin-Potassium Clavulanate Combination
18 beta-Lactamase Inhibitors
19 Clavulanic Acid

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas (Study P04460) Withdrawn NCT00202891 Phase 4 sisomicin
2 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
3 A Study Assessing the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Participants in Japan Recruiting NCT03311464 Phase 3 adalimumab
4 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
5 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
6 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
7 Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
8 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
9 Canakinumab for Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
10 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
11 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Recruiting NCT03137160 Phase 2
12 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2 Secukinumab
13 Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum Recruiting NCT03072953 Phase 2 APD334
14 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Recruiting NCT02902822 Phase 2
15 Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira;Humira
16 Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00690846 Phase 2 adalimumab
17 Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease Completed NCT00791557 Infliximab
18 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
19 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
20 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
21 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
22 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
23 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
24 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
25 A Real World, Observational Registry of Chronic Wounds and Ulcers Recruiting NCT02280733

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

MalaCards organs/tissues related to Pyoderma:

39
Skin, Neutrophil, Lung, T Cells, Myeloid, Bone, Monocytes

Publications for Pyoderma

Articles related to Pyoderma:

(show top 50) (show all 859)
id Title Authors Year
1
Extensive Pyoderma Gangrenosum: A Challenging Diagnosis and Literature Review of Management. ( 28944125 )
2017
2
Topical Medical Cannabis (TMC): A new treatment for wound pain-Three cases of Pyoderma Gangrenosum. ( 28818631 )
2017
3
Questionnaire survey of detrimental fur animal epidemic necrotic pyoderma in Finland. ( 28774326 )
2017
4
A case of eosinophilic fasciitis associated with pyoderma gangrenosum. ( 28150344 )
2017
5
Pyoderma gangrenosum in pregnancy successfully treated with infliximab and prednisone. ( 28879220 )
2017
6
Pyoderma Gangrenosum after Breast Mastectomy and Primary Rectus Abdominis Flap Reconstruction. ( 28871582 )
2017
7
Establishing a canine superficial pyoderma model. ( 27891724 )
2017
8
Reconstructive microsurgical approach for the treatment of pyoderma gangrenosum. ( 28918934 )
2017
9
Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment. ( 28943508 )
2017
10
Pyoderma gangrenosum associated with Crohn's disease in a Malawian teenage boy: case report and review of literature. ( 28767000 )
2017
11
Image Gallery: Pyoderma gangrenosum in a patient with myelodysplastic syndrome treated with azacitidine. ( 28940271 )
2017
12
Granulomatosis with Polyangiitis Presenting with Pyoderma Gangrenosum-Like Ulceration and Negative Cytoplasmic Antineutrophilic Cytoplasmic Antibodies in a Child. ( 28884919 )
2017
13
Comparison of pyoderma gangrenosum and hypertensive ischemic leg ulcer Martorell in a Swiss cohort. ( 28832960 )
2017
14
Pyoderma Gangrenosum: A Current Problem as Much as an Unknown One. ( 28915774 )
2017
15
Sporotrichosis masquerading as pyoderma gangrenosum. ( 28627095 )
2017
16
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature. ( 28884797 )
2017
17
Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. ( 28596664 )
2017
18
Pyoderma gangrenosum in a patient with chronic granulomatous disease: A case report. ( 28767612 )
2017
19
Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature. ( 28933699 )
2017
20
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
21
Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia. ( 28761297 )
2017
22
Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with hypogammaglobulinemia. ( 28815770 )
2017
23
Pyoderma gangrenosum affecting the eye, orbit, and adnexa. A review. ( 28862478 )
2017
24
Iliopsoas and intraperitoneal abscesses associated with pyoderma gangrenosum. ( 28869344 )
2017
25
Pyoderma Gangrenosum as the Initial Manifestation of Small Cell Lung Cancer with Dermatomyositis. ( 28836564 )
2017
26
Risk of Developing Pyoderma Gangrenosum after Procedures in Patients with a Known History of Pyoderma Gangrenosum - A Retrospective Analysis. ( 28947285 )
2017
27
Severe Bilateral Lower Extremity Pyoderma Gangrenosum. ( 27980702 )
2016
28
Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum. ( 27864925 )
2016
29
Biologics for the treatment of pyoderma gangrenosum in ulcerative colitis. ( 27799888 )
2016
30
Concomitant Pyoderma Gangrenosum and Erythema Nodosum in a Patient With Ulcerative Colitis. ( 27474109 )
2016
31
Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis. ( 27384061 )
2016
32
Intestinal BehAset's disease with pyoderma gangrenosum successfully treated with the combination therapy of adalimumab and glucocorticoids. ( 27142127 )
2016
33
Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases. ( 28025853 )
2016
34
Intractable Postoperative Wounds Caused by Self-Inflicted Trauma in a Patient with Cutaneous Munchausen Syndrome Presenting as a Pyoderma Gangrenosum-Like Lesion. ( 27194978 )
2016
35
Pyoderma Gangrenosum in a Patient With Hereditary Spherocytosis. ( 26711368 )
2016
36
Pyoderma gangrenosum: A clinico-epidemiological study. ( 27549869 )
2016
37
Post Surgical Pyoderma Gangrenosum in flap surgery: diagnostic clues and treatment recommendations. ( 27938245 )
2016
38
Hyperbaric Oxygen Therapy for the Adjunctive Treatment of Pyoderma Gangrenosum: A Case Report. ( 27192719 )
2016
39
Severe pyoderma gangrenosum in association with a flame burn. ( 27583260 )
2016
40
Pyogenic Arthritis, Pyoderma Gangrenosum, Acne, Suppurative Hidradenitis (PA-PASH) Syndrome: An Atypical Presentation of a Rare Syndrome. ( 27530224 )
2016
41
Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I. ( 27219252 )
2016
42
Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. ( 27617462 )
2016
43
Successful Treatment of Pyoderma Gangrenosum after Augmentation Mastopexy Using Vacuum Therapy. ( 27975008 )
2016
44
Unusual cause of breast wound: postoperative pyoderma gangrenosum. ( 27444684 )
2016
45
Successful treatment of large refractory pyoderma gangrenosum-like presentation of granulomatosis with polyangiitis with rituximab. ( 27126548 )
2016
46
Postsurgical pyoderma gangrenosum successfully treated with cyclosporine. ( 27852992 )
2016
47
Case of facial pyoderma gangrenosum. ( 27027635 )
2016
48
Multiple Pyoderma Gangrenosum Ulcers Associated with Cocaine Abuse. ( 28003907 )
2016
49
Autoinflammation in pyoderma gangrenosum and its syndromic form PASH. ( 27943240 )
2016
50
Generalized Pyoderma Gangrenosum Associated with Ulcerative Colitis: Successful Treatment with Infliximab and Azathioprine. ( 27149138 )
2016

Variations for Pyoderma

Expression for Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for Pyoderma

Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BTK CXCL8 IFNA2 IL1R1 ITGB2 MEFV
2
Show member pathways
13.26 BTK CXCL8 ITGB2 MMP1 MMP10 MMP9
3
Show member pathways
13.03 CXCL8 IFNA2 IL1R1 ITGB2 MMP1 MMP9
4
Show member pathways
12.74 BTK CXCL8 IFNA2 TNF
5
Show member pathways
12.61 ITGB2 MMP1 MMP10 MMP9
6
Show member pathways
12.21 CXCL8 MMP1 MMP9 TNF
7 12.08 IFNA2 ITGB2 NOD2 TNF
8
Show member pathways
12.07 CXCL8 IL1R1 TNF
9 12.06 MMP1 MMP9 TNF
10
Show member pathways
12.06 BTK CXCL8 IFNA2 IL1R1 MEFV NOD2
11
Show member pathways
12.01 CXCL8 IFNA2 TNF
12 11.96 IL1R1 MMP9 TNF
13 11.93 CXCL8 IFNA2 TNF
14 11.91 BTK IL1R1 TNF
15 11.87 CXCL8 IL1R1 MMP9 TNF
16
Show member pathways
11.85 MEFV NOD2 PSTPIP1
17 11.81 MMP9 NOD2 TNF
18
Show member pathways
11.77 MMP1 MMP10 MMP9 TNF
19 11.74 CXCL8 IL1R1 ITGB2 TNF
20 11.71 BTK CXCL8 IL1R1 TNF
21 11.66 CXCL8 ITGB2 TNF
22 11.63 CXCL8 MMP1 MMP9
23 11.62 CXCL8 ITGB2 MMP1 TNF
24 11.56 CXCL8 MMP9 TNF
25 11.48 CXCL8 ITGB2 TNF
26 11.42 CXCL8 IL1R1 TNF
27 11.41 CXCL8 ITGB2 TNF
28 11.41 CXCL8 ITGB2 MMP1 MMP9 TNF
29 11.39 ITGB2 MMP9 TNF
30
Show member pathways
11.36 CXCL8 MMP1 MMP9 TNF
31 11.24 CXCL8 MMP1 MMP10 MMP9
32 11.22 CXCL8 MMP1 MMP9
33 11.06 IL1R1 MMP9
34 11.03 CXCL8 TNF
35 11.01 NOD2 TNF
36 10.92 CXCL8 TNF
37 10.85 MMP1 MMP9

GO Terms for Pyoderma

Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.46 APOH MMP1 MMP10 MMP9
2 cell surface GO:0009986 9.35 APOH IL1R1 ITGB2 NOD2 TNF
3 extracellular region GO:0005576 9.23 APOH CXCL8 IFNA2 IL1R1 MMP1 MMP10

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.77 BTK IFNA2 MEFV NOD2 PSTPIP1
2 leukocyte migration GO:0050900 9.62 ITGB2 MMP1 MMP9 TNF
3 extracellular matrix disassembly GO:0022617 9.61 MMP1 MMP10 MMP9
4 collagen catabolic process GO:0030574 9.58 MMP1 MMP10 MMP9
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.49 MMP9 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.48 NOD2 TNF
7 embryonic digestive tract development GO:0048566 9.46 CXCL8 TNF
8 defense response GO:0006952 9.46 CXCL8 IFNA2 NOD2 TNF
9 cellular extravasation GO:0045123 9.26 ITGB2 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 BTK ITGB2 NOD2 TNF
11 inflammatory response GO:0006954 9.1 CXCL8 IFNA2 ITGB2 MEFV PSTPIP1 TNF

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.33 MMP1 MMP10 MMP9
2 metalloendopeptidase activity GO:0004222 9.13 MMP1 MMP10 MMP9
3 identical protein binding GO:0042802 8.92 APOH BTK MMP9 TNF

Sources for Pyoderma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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