MCID: PYD002
MIFTS: 51

Pyoderma malady

Skin diseases category
Download this MalaCard

Summaries for Pyoderma

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as... more...

MalaCards: Pyoderma is related to pyoderma gangrenosum and ulcerative colitis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Signaling by Interleukins and Interleukin-1 signaling. The compounds methotrexate and il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are liver/biliary system and skeleton.

Disease Ontology:8 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

Aliases & Classifications for Pyoderma

About this section
Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pyoderma 8 45 62


External Ids:

Disease Ontology8 DOID:4223
MeSH35 D011711
ICD9CM27 686.0, 686.00
ICD1025 L08.0

Related Diseases for Pyoderma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pyoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum31.6NOD2, NLRP3, MVK, MEFV, PSTPIP1
2ulcerative colitis30.8NOD2, IL1R1
3inflammatory bowel disease30.7PSTPIP1, IL1R1, NOD2
4arthritis30.4PSTPIP1, MEFV, MVK, IL1R1, NLRP3, NOD2
5rheumatoid arthritis30.2MEFV, IL1R1, NOD2
6dermatitis30.2NOD2, NLRP3
7cataract29.7IL1R1, MVK
8acne10.5
9pyogenic arthritis, pyoderma gangrenosum and acne10.5
10crohn's disease10.4
11blastomycosis10.4
12myelodysplastic syndromes10.4
13hidradenitis10.3
14vasculitis10.3
15breast reconstruction10.3
16subcorneal pustular dermatosis10.3
17pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.3
18hidradenitis suppurativa10.2
19takayasu's arteritis10.2
20ecthyma10.2
21leukemia10.2
22myeloma10.2
23agammaglobulinemia10.1
24hepatitis10.1
25osteomyelitis10.1
26psoriasis10.1
27scabies10.1
28chronic recurrent multifocal osteomyelitis10.1
29collagenous colitis10.1
30relapsing polychondritis10.1
31leukocyte adhesion deficiency10.1
32necrotizing fasciitis10.1
33folliculitis10.1
34systemic lupus erythematosus10.1
35sporotrichosis10.1
36behcet's disease10.1
37fasciitis10.1
38lupus erythematosus10.1
39otitis externa10.1
40erythema elevatum diutinum10.1
41periodic fever, familial, autosomal dominant10.0MEFV, MVK
42relapsing fever10.0MVK, MEFV
43familial mediterranean fever10.0MEFV, NLRP3
44rheumatic disease10.0MEFV, IL1R1
45aseptic meningitis10.0IL1R1, NLRP3
46iga glomerulonephritis10.0IL1R1, MEFV
47acute graft versus host disease10.0IL1R1, NOD2
48ankylosing spondylitis10.0NOD2, IL1R1
49burns10.0
50rosacea10.0

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to pyoderma

Symptoms for Pyoderma

About this section

Drugs & Therapeutics for Pyoderma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pyoderma

Search NIH Clinical Center for Pyoderma

Genetic Tests for Pyoderma

About this section

Anatomical Context for Pyoderma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pyoderma:

33
Skin, Breast, T cells, Myeloid, Bone, Lung, Monocytes, Bone marrow, Prostate, Testes, Liver, Heart, Endothelial

Animal Models for Pyoderma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Pyoderma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6IL1R1, NLRP3, MEFV
2MP:00053908.1NOD2, NLRP3, IL1R1, MEFV
3MP:00053788.1NOD2, NLRP3, IL1R1, MEFV
4MP:00053848.0NOD2, MEFV, IL1R1, NLRP3
5MP:00053977.8NOD2, PSTPIP1, MEFV, IL1R1, NLRP3
6MP:00053877.7NLRP3, IL1R1, MEFV, PSTPIP1, NOD2

Publications for Pyoderma

About this section
Sources:
52PubMed
See all sources

Articles related to Pyoderma:

(show top 50)    (show all 666)
idTitleAuthorsYear
1
Pyoderma gangrenosum with renal and splenic impairment - case report. (24346905)
2013
2
Penile pyoderma gangrenosum. (24339469)
2013
3
Letter to the editor: Temporary renal insufficiency associated with topical tacrolimus treatment of multilocal pyoderma gangrenosum. (24133568)
2013
4
Pyoderma gangrenosum in a newborn - case report. (24346911)
2013
5
Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma. (23331693)
2013
6
Dermacase. Can you identify this condition? Pyoderma gangrenosum. (23585606)
2013
7
Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications. (23661290)
2013
8
Auricular pyoderma gangrenosum associated with Crohn's disease. (22585655)
2012
9
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
10
Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab. (22301049)
2012
11
Superficial granulomatous pyoderma of the face: a case report and review of the literature. (23308303)
2012
12
Nasal carriage of Staphylococcus schleiferi from healthy dogs and dogs with otitis, pyoderma or both. (22771206)
2012
13
Pyoderma gangrenosum in breast reconstruction. (22747349)
2012
14
Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China. (22229826)
2012
15
Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. (22534879)
2012
16
Penile pyoderma gangrenosum successfully treated with topical Imiquimod. (22021975)
2011
17
Staged correction of an equinovarus deformity due to pyoderma gangrenosum using a Taylor spatial frame and tibiotalar calcaneal fusion with an intramedullary device. (21863298)
2011
18
Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum. (22281912)
2011
19
Pyoderma gangrenosum following trauma of the knee: a case of pathergy and review of orthopaedic cases. (20638661)
2011
20
Tattoo related pyoderma/ectyma gangrenous as presenting feature of relapsed acute myeloid leukaemia: an exceptionally rare observation. (20883993)
2011
21
Ciprofloxacin induced pyoderma gangrenosum. (23130244)
2011
22
Pyoderma gangrenosum of the breast after bilateral simple mastectomies for ductal carcinoma in situ. (21944335)
2011
23
Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. (19846444)
2010
24
Beclometasone inhaler used to treat pyoderma gangrenosum. (20500206)
2010
25
Superficial granulomatous pyoderma: a case in an 11-year-old girl and review of the literature. (21182640)
2010
26
A case of pyoderma gangrenosum with ulcerative colitis treated with mesalazine. (21165212)
2010
27
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. (19673875)
2009
28
Adalimumab treatment for peristomal pyoderma gangrenosum associated with Crohn's disease. (18942748)
2009
29
Early diagnosis and early corticosteroid administration improves healing of peristomal pyoderma gangrenosum in inflammatory bowel disease. (19279428)
2009
30
Seat belt pyoderma gangrenosum: minor pressure as a causative factor. (18837131)
2008
31
Pyoderma gangrenosum of the scalp following hair highlights in a postpartum patient. (18086612)
2008
32
An open-label pilot study of alefacept for the treatment of pyoderma gangrenosum. (18384543)
2008
33
A novel therapy for the treatment of pyoderma gangrenosum. (18935734)
2008
34
Pyoderma gangrenosum in the head and neck. (17224531)
2007
35
Negative pressure dressing in the management of pyoderma gangrenosum ulcer. (17938337)
2007
36
Pulmonary manifestations of Pyoderma gangrenosum. (17555913)
2007
37
Pyoderma gangrenosum in an infant. (16918628)
2006
38
The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum. (16415387)
2006
39
A case of pyoderma gangrenosum responding to high-dose intravenous immunoglobulin therapy. (16863619)
2006
40
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. (17047113)
2006
41
Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis. (16428159)
2005
42
Small joint monoarthritis and pyoderma gangrenosum in newly diagnosed ulcerative colitis: an unusual presentation. (17043551)
2004
43
Pyoderma gangrenosum complicated by ecthyma gangrenosum. (15149521)
2004
44
Pyoderma and scabies: a benign association? (12734437)
2003
45
A case of SAPHO syndrome with pyoderma gangrenosum and inflammatory bowel disease masquerading as BehAset's disease. (12918720)
2003
46
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. (9212761)
1997
47
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
48
Klippel-Trenaunay-Weber syndrome mimicking pyoderma gangrenosum. (8537163)
1995
49
Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases. (1572226)
1992
50
Pyoderma gangrenosum followed by subcorneal pustular dermatosis in a patient with IgA paraproteinemia. (1999540)
1991

Variations for Pyoderma

About this section

Expression for genes affiliated with Pyoderma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for genes affiliated with Pyoderma

About this section
Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 30KEGG
See all sources

Compounds for genes affiliated with Pyoderma

About this section
Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Pyoderma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1methotrexate51 45 1111.3NLRP3, IL1R1
2il 10459.2IL1R1, NOD2
3infliximab45 51 1111.2IL1R1, NOD2
4peptidoglycan45 2910.1IL1R1, NOD2
5mevalonate459.1MEFV, MVK, NLRP3
6anakinra45 1110.0MVK, IL1R1, NLRP3
7endotoxin458.9MEFV, IL1R1, NOD2
8prednisolone45 29 1110.8IL1R1, NOD2
9threonine458.1NOD2, NLRP3, IL1R1, MVK
10serine458.1NOD2, IL1R1, PSTPIP1, MVK

GO Terms for genes affiliated with Pyoderma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.6NOD2, NLRP3, MVK, MEFV, PSTPIP1

Biological processes related to Pyoderma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:0326959.4NOD2, MEFV
2detection of biotic stimulusGO:0095959.3NLRP3, NOD2
3positive regulation of interleukin-1 beta secretionGO:0507189.2NLRP3, NOD2
4regulation of inflammatory responseGO:0507279.1IL1R1, NOD2
5negative regulation of inflammatory responseGO:0507289.1NLRP3, MVK, MEFV
6inflammatory responseGO:0069549.1NLRP3, MEFV, PSTPIP1
7protein oligomerizationGO:0512599.1NOD2, NLRP3
8positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, NLRP3
9defense responseGO:0069528.9NOD2, NLRP3
10negative regulation of NF-kappaB transcription factor activityGO:0320888.7NOD2, NLRP3
11nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.4NOD2, NLRP3, MEFV, PSTPIP1
12innate immune responseGO:0450878.4NOD2, NLRP3, MEFV, PSTPIP1

Molecular functions related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.0NOD2, NLRP3

Products for genes affiliated with Pyoderma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyoderma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet