MCID: PYD002
MIFTS: 49

Pyoderma malady

Skin diseases category

Summaries for Pyoderma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as... more...

MalaCards: Pyoderma is related to pyoderma gangrenosum and ulcerative colitis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and TRAF6 Mediated Induction of proinflammatory cytokines. The compounds anakinra and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are integument and immune system.

Disease Ontology:8 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

Aliases & Classifications for Pyoderma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pyoderma 8 44 60


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Disease Ontology8 DOID:4223
MeSH34 D011711
ICD9CM27 686.00, 686.0
ICD1025 L08.0

Related Diseases for Pyoderma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum31.7NLRP3, MVK, PSTPIP1, MEFV, MESDC1, NOD2
2ulcerative colitis30.8NOD2, IL1R1, PRTN3, ITGB2
3inflammatory bowel disease30.7NOD2, IL1R1, PRTN3, ITGB2, PSTPIP1
4arthritis30.6NLRP3, MVK, PSTPIP1, MEFV, ITGB2, PRTN3
5crohn's disease30.6NOD2
6vasculitis30.3PRTN3, ITGB2, MEFV, APOH
7rheumatoid arthritis30.2NOD2, IL1R1, BTK, PRTN3, ITGB2, MEFV
8dermatitis30.2NLRP3, ITGB2, NOD2
9leukemia30.2IDS, ITGB2, PRTN3, BTK, IL1R1
10psoriasis30.2ITGB2, IL1R1, NOD2, SERPINB13
11osteomyelitis30.1PSTPIP2
12lupus erythematosus30.0APOH
13systemic lupus erythematosus30.0APOH, ITGB2, PRTN3, IL1R1, NOD2
14sapho syndrome29.9PSTPIP2
15squamous cell carcinoma29.9ITGB2, PRTN3, IL1R1, MMP10, MMP26, SERPINB13
16pneumonia29.7BTK
17polyarteritis nodosa29.7MEFV, PRTN3
18conjunctivitis29.7NLRP3
19urticaria29.7ITGB2, NLRP3
20multiple sclerosis29.7ITGB2, IL1R1
21wegener's granulomatosis29.7PRTN3, ITGB2
22glomerulonephritis29.7IL1R1, PRTN3, ITGB2
23acne10.4
24blastomycosis10.4
25pyogenic arthritis, pyoderma gangrenosum and acne10.3
26hidradenitis10.3
27breast reconstruction10.2
28subcorneal pustular dermatosis10.2
29hidradenitis suppurativa10.2
30takayasu's arteritis10.2
31ecthyma10.2
32myeloma10.2
33pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
34agammaglobulinemia10.1
35cutaneous t cell lymphoma10.1
36hepatitis10.1
37scabies10.1
38antiphospholipid syndrome10.0
39relapsing polychondritis10.0
40folliculitis10.0
41leukocyte adhesion deficiency10.0
42necrotizing fasciitis10.0
43behcet's disease10.0
44sporotrichosis10.0
45acute leukemia10.0
46fasciitis10.0
47otitis externa10.0
48mevalonic aciduria10.0MVK
49spondylitis10.0NOD2
50amyloidosis10.0MEFV

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to pyoderma

Clinical Features for Pyoderma

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Drugs & Therapeutics for Pyoderma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pyoderma

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Genetic Tests for Pyoderma

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Anatomical Context for Pyoderma

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32MalaCards
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MalaCards organs/tissues related to Pyoderma:

32
Skin, Breast, T cells, Myeloid, Bone, Lung, Monocytes, Bone marrow, Endothelial, Testes, Heart, Liver, Prostate

Animal Models for Pyoderma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyoderma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2IDS, PSTPIP2, MEFV, ITGB2, BTK, IL1R1
2MP:00053878.2NOD2, NLRP3, IDS, PSTPIP1, PSTPIP2, MEFV

Publications for Pyoderma

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50PubMed
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Articles related to Pyoderma:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Understanding methicillin resistance in staphylococci isolated from dogs with pyoderma. (24004228)
2013
2
Extensive postoperative pyoderma gangrenosum. (23314452)
2013
3
Treatment of a relapsing facial pyoderma gangrenosum (malignant pyoderma). (23330662)
2013
4
A case of antibacterial-responsive mucocutaneous disease in a seven-year-old dwarf lop rabbit (Oryctolagus cuniculus) resembling mucocutaneous pyoderma of dogs. (23346925)
2013
5
Systematic review: IBD-associated pyoderma gangrenosum in the biologic era, the response to therapy. (23914999)
2013
6
Education and imaging. Gastrointestinal: severe inflammatory bowel disease-associated pyoderma gangrenosum. (24147454)
2013
7
Retinal vasculitis associated with pyoderma gangrenosum: a case report. (22669709)
2012
8
Letter: Treatment-resistant pyoderma gangrenosum. (22559023)
2012
9
Propylthiouracil-induced antineutrophil cytoplasmic antibody positive vasculitis clinically mimicking pyoderma gangrenosum. (22132781)
2012
10
Photoletter to the editor: Scarring alopecia resulting from pyoderma gangrenosum of the scalp. (22514589)
2012
11
The use of etanercept in the treatment of peristomal pyoderma gangrenosum. (22582915)
2012
12
The effectiveness of systemic antimicrobial treatment in canine superficial and deep pyoderma: a systematic review. (22734856)
2012
13
Ustekinumab for pyoderma gangrenosum-reply. (23752957)
2012
14
Penile pyoderma gangrenosum successfully treated with topical Imiquimod. (22021975)
2011
15
Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum. (22281912)
2011
16
Pyoderma gangrenosum in a renal transplantation patient having immunosuppressive treatment for 5 years. (21902729)
2011
17
Ulcerative colitis complicated by atypical peristomal pyoderma gangrenosum. (21630389)
2011
18
Pyoderma gangrenosum: an Indian perspective. (21070329)
2011
19
Severe pyoderma gangrenosum unresponsive to etanercept and adalimumab. (20673157)
2011
20
Adalimumab for pyoderma gangrenosum associated with inflammatory bowel disease. (21953808)
2011
21
Necrotizing fasciitis versus pyoderma gangrenosum: securing the correct diagnosis! A case report and literature review. (21625613)
2011
22
Use of infliximab in a patient with pyoderma gangrenosum and rheumatoid arthritis. (20680379)
2010
23
A case of atypical pyoderma gangrenosum. (21886741)
2010
24
Pyoderma gangrenosum. (20213372)
2010
25
Good response of a combined treatment of acitretin and antibiotics in blastomycosis-like pyoderma. (19213654)
2009
26
Development of pyoderma gangrenosum during therapy with infliximab. (21886723)
2009
27
Traumatic pyoderma gangrenosum of the face: pathergy development after bike accident. (19060470)
2009
28
An open-label pilot study of alefacept for the treatment of pyoderma gangrenosum. (18384543)
2008
29
The clinical and histopathological description of geometric phagedenism (pyoderma gangrenosum) by Louis Brocq one century ago. (18559764)
2008
30
Successful treatment of pyoderma gangrenosum associated with myelodysplastic syndrome using high-dose intravenous immunoglobulin. (19043265)
2008
31
Successful treatment of severe pyoderma gangrenosum with pimecrolimus cream 1%. (18181988)
2008
32
Pyoderma gangrenosum. (19086358)
2008
33
Pyoderma faciale. (18666391)
2008
34
Response to infliximab in atypical pyoderma gangrenosum associated with ulcerative colitis. (19032482)
2008
35
Superficial granulomatous pyoderma gangrenosum of the penis: a case report. (17619745)
2007
36
Extranodal NK/T-cell lymphoma nasal type mimicking pyoderma gangrenosum. (17340032)
2007
37
Use of infliximab in pyoderma gangrenosum. (17535196)
2007
38
Pyoderma gangrenosum in an infant. (16918628)
2006
39
Pyoderma gangrenosum associated with isotretinoin therapy. (17052521)
2006
40
Pyoderma Gangrenosum and Full-Thickness Burns: is there a Problem of Differential Diagnosis? (21991027)
2006
41
Factitious panniculitis masquerading as pyoderma gangrenosum. (15807683)
2005
42
Small joint monoarthritis and pyoderma gangrenosum in newly diagnosed ulcerative colitis: an unusual presentation. (17043551)
2004
43
Pyoderma gangrenosum. (17642880)
2003
44
Tinea capitis in adult women masquerading as bacterial pyoderma. (12894115)
2003
45
Pyoderma gangrenosum, erythema elevatum diutinum and IgA monoclonal gammopathy. (7763217)
1995
46
Pyoderma gangrenosum followed by subcorneal pustular dermatosis in a patient with IgA paraproteinemia. (1999540)
1991
47
Cutaneous vasculitis, hypersensitivity vasculitis, erythema nodosum, and pyoderma gangrenosum. (2043448)
1991
48
Pyoderma gangrenosum complicating Felty's syndrome. (2213783)
1990
49
Pyoderma gangrenosum associated with transient acantholytic dermatosis (pemphigus erythematosus-like) and paraproteinemia. (6164226)
1981
50
Two cases of pyoderma (ecthyma) gengraenosum associated with the presence of an abnormal serumprotein (beta-2-A-paraprotein). With a review of the literature. (5332036)
1966

Genetic Variations for Pyoderma

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Expression for genes affiliated with Pyoderma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for genes affiliated with Pyoderma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Pathways related to Pyoderma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MEFV, PSTPIP1, NLRP3
2
Hide members
10.0NOD2, BTK, ITGB2
3
Hide members
9.9NOD2, MEFV, PSTPIP1, NLRP3
49.9SERPINB13, IL1R1, ITGB2
5
Hide members
9.8NLRP3, BTK, IL1R1, NOD2
6
Hide members
9.5NLRP3, PSTPIP1, MEFV, ITGB2, BTK, IL1R1

Compounds for genes affiliated with Pyoderma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 28IUPHAR, 24HMDB
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Compounds related to Pyoderma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1anakinra44 1111.3IL1R1, MVK, NLRP3
2mevalonate4410.2NLRP3, MVK, MEFV, ITGB2
3hydroxychloroquine44 1111.1IL1R1, APOH
4infliximab44 49 1112.0NOD2, IL1R1, PRTN3, APOH
5ivig4410.0APOH, ITGB2, BTK, IL1R1
6rituximab44 49 1112.0IL1R1, PRTN3, APOH
7procainamide44 1111.0APOH, ITGB2
8propylthiouracil44 2 1112.0APOH
9prednisolone44 28 1112.0APOH, ITGB2, IL1R1, NOD2
10endotoxin449.9APOH, MEFV, ITGB2, IL1R1, NOD2
11gold449.8IL1R1, PRTN3, APOH
12fibrinogen449.7APOH, ITGB2, BTK, IL1R1, MMP26
13threonine449.7NLRP3, MVK, ITGB2, BTK, IL1R1, NOD2
14atp44 2810.6NLRP3, MVK, APOH, GUCA1A, ITGB2, BTK
15cysteine449.4IDS, GUCA1A, ITGB2, BTK, IL1R1, SERPINB13
16serine449.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
17calcium44 49 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, BTK

GO Terms for genes affiliated with Pyoderma

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16Gene Ontology
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Biological processes related to Pyoderma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.4NOD2, NLRP3
2negative regulation of interleukin-12 productionGO:03269510.3NOD2, MEFV
3negative regulation of inflammatory responseGO:05072810.2MEFV, MVK, NLRP3
4positive regulation of interleukin-1 beta secretionGO:05071810.2NOD2, NLRP3
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.1NOD2, MEFV, PSTPIP1, NLRP3
6toll-like receptor 4 signaling pathwayGO:03414210.0NOD2, BTK, ITGB2
7collagen catabolic processGO:03057410.0PRTN3, MMP10, MMP26
8positive regulation of NF-kappaB transcription factor activityGO:0510929.9NLRP3, BTK, NOD2
9toll-like receptor signaling pathwayGO:0022249.7ITGB2, BTK, NOD2
10innate immune responseGO:0450879.6NLRP3, PSTPIP1, MEFV, ITGB2, BTK, NOD2

Molecular functions related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma

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  • Antibodies
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Sources for Pyoderma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet