MCID: PYD002
MIFTS: 43

Pyoderma malady

Skin category

Summaries for Pyoderma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as... more...

MalaCards: Pyoderma is related to pyoderma gangrenosum and ulcerative colitis. An important gene associated with Pyoderma is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and TRAF6 Mediated Induction of proinflammatory cytokines. The compounds anakinra and mevalonate have been mentioned in the context of this disorder. Related mouse phenotypes are integument and immune system.

Disease Ontology:8 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

Aliases & Classifications for Pyoderma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

pyoderma 8 45 61


External Ids:

Disease Ontology8 DOID:4223
MeSH35 D011711
ICD9CM27 686.00, 686.0
ICD1025 L08.0

Related Diseases for Pyoderma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pyoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1pyoderma gangrenosum31.8NLRP3, MVK, PSTPIP1, MEFV, MESDC1, NOD2
2ulcerative colitis30.9NOD2, IL1R1, PRTN3, ITGB2
3arthritis30.7NLRP3, MVK, PSTPIP1, MEFV, ITGB2, PRTN3
4vasculitis30.4PRTN3, ITGB2, MEFV, APOH
5crohn's disease30.2NOD2
6systemic lupus erythematosus30.1APOH, ITGB2, PRTN3, IL1R1, NOD2
7sapho syndrome29.9PSTPIP2
8squamous cell carcinoma29.9ITGB2, PRTN3, IL1R1, MMP10, MMP26, SERPINB13
9polyarteritis nodosa29.7MEFV, PRTN3
10urticaria29.7ITGB2, NLRP3
11wegener's granulomatosis29.7PRTN3, ITGB2
12rheumatic disease29.7APOH, MEFV, IL1R1
13acne10.5
14blastomycosis10.4
15pyogenic arthritis, pyoderma gangrenosum and acne10.4
16n syndrome10.3
17subcorneal pustular dermatosis10.3
18breast reconstruction10.2
19hidradenitis suppurativa10.2
20ecthyma10.2
21pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.2
22pyoderma gangrenosum - acne - suppurative hidradenitis10.2
23agammaglobulinemia10.1
24chronic recurrent multifocal osteomyelitis10.1
25collagenous colitis10.1
26antiphospholipid syndrome10.1
27relapsing polychondritis10.1
28folliculitis10.1
29hepatitis e10.1
30leukocyte adhesion deficiency10.1
31necrotizing fasciitis10.1
32sporotrichosis10.1
33acute leukemia10.1
34hepatitis a10.1
35erythema elevatum diutinum10.1
36burns10.0
37paronychia10.0
38rheumatic fever10.0
39rosacea10.0
40cicatricial ectropion10.0
41cellulitis10.0
42common variable immunodeficiency10.0
43pharyngitis10.0
44pemphigus10.0
45autoimmune hepatitis10.0
46behcet's disease10.0
47adenocarcinoma10.0
48acute febrile neutrophilic dermatosis10.0
49chronic myelomonocytic leukemia10.0
50lymphomatoid papulosis10.0

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to pyoderma

Clinical Features for Pyoderma

Drugs & Therapeutics for Pyoderma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pyoderma

Drug clinical trials:

Search ClinicalTrials for Pyoderma

Search NIH Clinical Center for Pyoderma

Search CenterWatch for Pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

Animal Models for Pyoderma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pyoderma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2IDS, PSTPIP2, MEFV, ITGB2, BTK, IL1R1
2MP:00053878.2NOD2, NLRP3, IDS, PSTPIP1, PSTPIP2, MEFV

Publications for Pyoderma

Sources:
51PubMed
See all sources

Articles related to Pyoderma:

(show top 50)    (show all 675)
idTitleAuthorsYear
1
Pyoderma gangrenosum with renal and splenic impairment - case report. (24346905)
2013
2
Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma. (23331693)
2013
3
Inpatient Management of Pyoderma Gangrenosum: Treatments, Outcomes, and Clinical Implications. (23903083)
2013
4
Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet's syndrome: a comprehensive review and disease classification criteria. (23334898)
2013
5
Predictive factors for erythema nodosum and pyoderma gangrenosum in inflammatory bowel disease. (23927379)
2013
6
Treatment of pyoderma gangrenosum with topical factor XIII. (24135449)
2013
7
Pyoderma gangrenosum in breast reconstruction. (22747349)
2012
8
Pyoderma gangrenosum in a patient with primary cutaneous peripheral T-cell lymphoma, not otherwise specified. (23228951)
2012
9
Pyoderma gangrenosum: a rare cause of breast ulceration. (22778682)
2012
10
Photoletter to the editor: Localized pyoderma gangrenosum after interferon-alpha2b injections. (23091590)
2012
11
Vulvar pyoderma gangrenosum with renal involvement. (22652578)
2012
12
Staged correction of an equinovarus deformity due to pyoderma gangrenosum using a Taylor spatial frame and tibiotalar calcaneal fusion with an intramedullary device. (21863298)
2011
13
Comparison of a chlorhexidine and a benzoyl peroxide shampoo as sole treatment in canine superficial pyoderma. (21831997)
2011
14
Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet's syndrome). (21410617)
2011
15
Pyoderma gangrenosum-like lesions in leukocyte adhesion deficiency I treated with intravenous immunoglobulin. (21366684)
2011
16
Blastomycosis-like pyoderma in association with recurrent vesicular hand eczema: good response to acitretin. (21426875)
2011
17
Ulcerative pyoderma gangrenosum in mixed connective tissue disorder: a rare association and role of azathioprine in the management. (22121294)
2011
18
Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. (19846444)
2010
19
Superficial granulomatous pyoderma with ocular involvement. (20719707)
2010
20
A novel approach to the management of pyoderma gangrenosum complicating reduction mammaplasty. (20442095)
2010
21
Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation. (20349240)
2010
22
Therapeutic hotline. Infliximab for treatment of resistant pyoderma gangrenosum associated with ulcerative colitis and psoriasis. A case report. (20868408)
2010
23
Necrotizing pyoderma gangrenosum: an unusual differential diagnosis of necrotizing fasciitis. (20202917)
2010
24
Pyoderma gangrenosum responding to ciclosporin without adverse effects in a patient with lymphomatoid papulosis. (20456406)
2010
25
In vitro antimicrobial susceptibility of staphylococci isolated from canine pyoderma in Rio de Janeiro, Brazil. (24031392)
2009
26
Monster parastomal pyoderma gangrenosum effectively treated by topical tacrolimus. (21172277)
2009
27
Mycophenolate mofetil as therapy for pyoderma gangrenosum. (19620559)
2009
28
Pyoderma gangrenosum in pregnancy. (19638335)
2009
29
Mycosis fungoides and CD30+ cutaneous T-cell lymphoma simulating pyoderma gangrenosum in a patient with ulcerative colitis. (21886726)
2009
30
Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases: a cohort study of 2402 patients. (18794711)
2008
31
Pyoderma gangrenosum affecting the vulva. (19052422)
2008
32
Pyoderma gangrenosum with pathergy in a pregnant patient without associated systemic disease. (18441849)
2008
33
Pyoderma gangrenosum in association with autoimmune neutropenia of infancy. (19067867)
2008
34
Efficacy and tolerability of once-daily cephalexin in canine superficial pyoderma: an open controlled study. (18631220)
2008
35
Successful treatment with infliximab of refractory pyoderma gangrenosum in 2 patients with inflammatory bowel diseases. (17508417)
2007
36
Oral amoxicillin vs. oral erythromycin in the treatment of pyoderma in Bamako, Mali: an open randomized trial. (17958625)
2007
37
Pyoderma gangrenosum developing during therapy with TNF-alpha antagonists in a patient with rheumatoid arthritis. (17876646)
2007
38
Diagnosis and treatment of pyoderma gangrenosum. (16858047)
2006
39
Pyoderma gangrenosum following reduction mammaplasty. (19554230)
2006
40
Rule out smallpox in the ED: an interesting case of streptococcus pyoderma. (16490659)
2006
41
Adverse reactions to gefitinib (Iressa): revealing sycosis- and pyoderma gangrenosum-like lesions. (16911406)
2006
42
Pyoderma gangrenosum in association with juvenile rheumatoid arthritis. (16361736)
2005
43
Successful surgical treatment of Takayasu's arteritis associated with pyoderma gangrenosum. (16242485)
2005
44
Outcome of pregnancy in a patient with relapsing polychondritis and pyoderma gangrenosum. (12447644)
2002
45
A nursery outbreak of Staphylococcus aureus pyoderma originating from a nurse with paronychia. (11918123)
2002
46
Pyoderma gangrenosum in a patient with autoimmune haemolytic anaemia and complement deficiency. (10886151)
2000
47
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
48
Pyoderma gangrenosum and subcorneal pustular dermatosis, without monoclonal gammopathy. (8148286)
1994
49
Pyoderma gangrenosum versus acute febrile neutrophilic dermatosis (Sweet's syndrome) (3674086)
1987
50
Epidemic staphylococcal pyoderma associated with Ritter's disease and the appearance of phage type 3B/71. (13975789)
1963

Genetic Variations for Pyoderma

Expression for genes affiliated with Pyoderma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for genes affiliated with Pyoderma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems
See all sources

Pathways related to Pyoderma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PSTPIP1, MEFV, NLRP3
2
Hide members
10.0ITGB2, BTK, NOD2
3
Hide members
9.9NLRP3, PSTPIP1, NOD2, MEFV
49.9ITGB2, IL1R1, SERPINB13
5
Hide members
9.8IL1R1, NOD2, NLRP3, BTK
6
Hide members
9.5IL1R1, BTK, ITGB2, MEFV, PSTPIP1, NLRP3

Compounds for genes affiliated with Pyoderma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB, 29IUPHAR, 24HMDB
See all sources

Compounds related to Pyoderma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1anakinra45 1111.3IL1R1, MVK, NLRP3
2mevalonate4510.2NLRP3, MVK, MEFV, ITGB2
3hydroxychloroquine45 1111.1IL1R1, APOH
4infliximab45 50 1112.0NOD2, IL1R1, PRTN3, APOH
5ivig4510.0APOH, ITGB2, BTK, IL1R1
6rituximab45 50 1112.0IL1R1, PRTN3, APOH
7procainamide45 1111.0APOH, ITGB2
8propylthiouracil45 2 1112.0APOH
9prednisolone45 29 1112.0APOH, ITGB2, IL1R1, NOD2
10endotoxin459.9APOH, MEFV, ITGB2, IL1R1, NOD2
11gold459.8IL1R1, PRTN3, APOH
12fibrinogen459.7APOH, ITGB2, BTK, IL1R1, MMP26
13threonine459.7NLRP3, MVK, ITGB2, BTK, IL1R1, NOD2
14atp45 2910.6NLRP3, MVK, APOH, GUCA1A, ITGB2, BTK
15cysteine459.4IDS, GUCA1A, ITGB2, BTK, IL1R1, SERPINB13
16serine459.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
17calcium45 50 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, BTK

GO Terms for genes affiliated with Pyoderma

Sources:
16Gene Ontology
See all sources

Biological processes related to Pyoderma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.4NOD2, NLRP3
2negative regulation of interleukin-12 productionGO:03269510.3NOD2, MEFV
3negative regulation of inflammatory responseGO:05072810.2MEFV, MVK, NLRP3
4positive regulation of interleukin-1 beta secretionGO:05071810.2NOD2, NLRP3
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.1NOD2, MEFV, PSTPIP1, NLRP3
6toll-like receptor 4 signaling pathwayGO:03414210.0NOD2, BTK, ITGB2
7collagen catabolic processGO:03057410.0PRTN3, MMP10, MMP26
8positive regulation of NF-kappaB transcription factor activityGO:0510929.9NLRP3, BTK, NOD2
9toll-like receptor signaling pathwayGO:0022249.7ITGB2, BTK, NOD2
10innate immune responseGO:0450879.6NLRP3, PSTPIP1, MEFV, ITGB2, BTK, NOD2

Molecular functions related to Pyoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyoderma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet