Aliases & Classifications for Pyoderma

MalaCards integrated aliases for Pyoderma:

Name: Pyoderma 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4223
ICD10 32 L08.0
ICD9CM 34 686.0 686.00
MeSH 41 D011711
UMLS 69 C0034212

Summaries for Pyoderma

Disease Ontology : 12 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

MalaCards based summary : Pyoderma is related to pyogenic arthritis, pyoderma gangrenosum and acne and ileocolitis, and has symptoms including pustular rash, pruritus and exanthema. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial... more...

Related Diseases for Pyoderma

Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 pyogenic arthritis, pyoderma gangrenosum and acne 34.3 IL1R1 PSTPIP1
2 ileocolitis 31.9 NOD2 TNF
3 pyoderma gangrenosum 31.9 CXCL8 IFNA2 ITGB2 MEFV MMP10 NOD2
4 ulcerative colitis 30.6 CXCL8 NOD2 TNF
5 colitis 30.6 CXCL8 NOD2 TNF
6 scleritis 30.3 ITGB2 TNF
7 sapho syndrome 30.0 CXCL8 NOD2
8 wegener granulomatosis 30.0 CXCL8 ITGB2 TNF
9 arthritis 30.0 CXCL8 MMP1 NOD2 TNF
10 pouchitis 29.9 CXCL8 NOD2
11 vasculitis 29.8 APOH IFNA2 MEFV TNF
12 inflammatory bowel disease 29.5 CXCL8 IL1R1 MMP1 NOD2 PSTPIP1 TNF
13 polyarteritis nodosa 29.4 APOH IFNA2 MEFV
14 rheumatoid arthritis 29.3 CXCL8 IL1R1 ITGB2 MMP1 TNF
15 purpura 29.0 APOH F3 TNF
16 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.2
17 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.0
18 gapo syndrome 11.2
19 cutaneous diphtheria 11.2
20 impetigo 11.2
21 corticosteroid-sensitive aseptic abscesses 11.2
22 actinic prurigo 11.0
23 polydactyly, postaxial, type a1 10.9
24 systemic onset juvenile idiopathic arthritis 10.5 MEFV TNF
25 autoinflammation, panniculitis, and dermatosis syndrome 10.5 MEFV TNF
26 vulvar vestibulitis syndrome 10.5 IL1R1 TNF
27 paratyphoid fever 10.5 IL1R1 TNF
28 tungiasis 10.5 CXCL8 TNF
29 streptococcal toxic-shock syndrome 10.4 CXCL8 TNF
30 familial cold autoinflammatory syndrome 1 10.4 IL1R1 MEFV
31 trichuriasis 10.4 CXCL8 TNF
32 haemophilus influenzae 10.4 CXCL8 TNF
33 erysipelas 10.4 MEFV TNF
34 granulomatous dermatitis 10.4 NOD2 TNF
35 relapsing fever 10.4 MEFV TNF
36 periodic fever, familial, autosomal dominant 10.4 MEFV TNF
37 clonorchiasis 10.4 CXCL8 TNF
38 kashin-beck disease 10.4 MMP1 TNF
39 sweat gland disease 10.4 PSTPIP1 TNF
40 meconium aspiration syndrome 10.3 CXCL8 TNF
41 dental pulp disease 10.3 CXCL8 TNF
42 mycobacterium abscessus 10.3 CXCL8 TNF
43 louse-borne relapsing fever 10.3 CXCL8 TNF
44 adult-onset still's disease 10.3 IL1R1 MEFV TNF
45 aseptic meningitis 10.3 CXCL8 IL1R1 TNF
46 adult respiratory distress syndrome 10.3 CXCL8 IL1R1 TNF
47 chorioamnionitis 10.3 CXCL8 IL1R1 TNF
48 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 CXCL8 IL1R1 TNF
49 pleurisy 10.3 CXCL8 MEFV TNF
50 papilledema 10.3 APOH IL1R1

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma

Symptoms & Phenotypes for Pyoderma

UMLS symptoms related to Pyoderma:


pustular rash, pruritus, exanthema

MGI Mouse Phenotypes related to Pyoderma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 BTK F3 IL1R1 ITGB2 MEFV NOD2
2 immune system MP:0005387 9.32 BTK F3 IL1R1 ITGB2 MEFV MMP1

Drugs & Therapeutics for Pyoderma

Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 3
2 Anti-Infective Agents Phase 4,Phase 3
3
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
4
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
5 Pharmaceutical Solutions Phase 3,Phase 2
6 Antirheumatic Agents Phase 3,Phase 2
7 Anti-Inflammatory Agents Phase 3,Phase 2
8
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
9 Dermatologic Agents Phase 2
10 Antibodies, Monoclonal Phase 2,Phase 1
11 Immunoglobulins Phase 2,Phase 1
12 Immunosuppressive Agents Phase 2
13 Antibodies Phase 2,Phase 1
14 Calcineurin Inhibitors Phase 2
15
Infliximab Approved 170277-31-3
16
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
17 Clavulanic Acid
18 Gastrointestinal Agents
19 Amoxicillin-Potassium Clavulanate Combination
20 Vaccines
21 beta-Lactamase Inhibitors

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas (Study P04460) Withdrawn NCT00202891 Phase 4 sisomicin
2 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
3 A Study Assessing the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Participants in Japan Recruiting NCT03311464 Phase 3 adalimumab
4 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
5 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
6 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
7 Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
8 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
9 Canakinumab for Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
10 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
11 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Recruiting NCT03137160 Phase 2
12 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2 Secukinumab
13 Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum Recruiting NCT03072953 Phase 2 APD334
14 Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira;Humira
15 Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00690846 Phase 2 adalimumab
16 Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease Completed NCT00791557 Infliximab
17 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
18 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
19 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
20 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
21 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
22 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
23 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
24 A Real World, Observational Registry of Chronic Wounds and Ulcers Recruiting NCT02280733
25 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

MalaCards organs/tissues related to Pyoderma:

38
Skin, Neutrophil, Lung, T Cells, Myeloid, Bone, Monocytes

Publications for Pyoderma

Articles related to Pyoderma:

(show top 50) (show all 888)
# Title Authors Year
1
A systematic review of pyoderma gangrenosum with pulmonmary involvement: clinical presentation, diagnosis, and management. ( 29377399 )
2018
2
The impact of underlying disease state on outcomes in patients with pyoderma gangrenosum: A national survey. ( 29438762 )
2018
3
Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis. ( 29422812 )
2018
4
Pyoderma gangrenosum successfully treated with topical tacrolimus. ( 29368849 )
2018
5
Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. ( 29450466 )
2018
6
A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )
2018
7
Cutaneous Diphtheria Mimicking Pyoderma Gangrenosum. ( 29282460 )
2018
8
Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report. ( 29425752 )
2018
9
Recurrent pyoderma and its underlying primary diseases: a retrospective evaluation of 157 dogs. ( 29419485 )
2018
10
Diagnosis uPGrade-Advances in Pyoderma Gangrenosum. ( 29450448 )
2018
11
Pyoderma gangrenosum in the genital area: successful treatment using adalimumab. ( 29378677 )
2018
12
Pyoderma Gangrenosum Under Dabrafenib and Trametinib for Metastatic Melanoma. ( 29362816 )
2018
13
Pyoderma gangrenosum: a review of pathogenesis and treatment. ( 29406827 )
2018
14
<i>LPIN2</i> gene mutation in a patient with overlapping neutrophilic disease (pyoderma gangrenosum and aseptic abscess syndrome). ( 29387759 )
2018
15
The PARACELSUS score: A novel diagnostic tool for pyoderma gangrenosum. ( 29388188 )
2018
16
Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma. ( 29386837 )
2018
17
The Validity of the Diagnostic Code for Pyoderma Gangrenosum in an Electronic Database. ( 29451671 )
2018
18
Suppression of pathergy in pyoderma gangrenosum with infliximab allowing for successful tendon debridement. ( 29379860 )
2018
19
Successful therapy of Pyoderma gangrenosum with a JAK2 inhibitor. ( 29451690 )
2018
20
Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum. ( 29243307 )
2018
21
The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum. ( 29450453 )
2018
22
Granulomatosis with Polyangiitis Presenting with Pyoderma Gangrenosum-Like Ulceration and Negative Cytoplasmic Antineutrophilic Cytoplasmic Antibodies in a Child. ( 28884919 )
2017
23
Establishing a canine superficial pyoderma model. ( 27891724 )
2017
24
Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. ( 28596664 )
2017
25
Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment. ( 28943508 )
2017
26
Pyoderma gangrenosum affecting the eye, orbit, and adnexa. A review. ( 28862478 )
2017
27
Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia. ( 28761297 )
2017
28
Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 28980537 )
2017
29
Risk of Developing Pyoderma Gangrenosum after Procedures in Patients with a Known History of Pyoderma Gangrenosum - A Retrospective Analysis. ( 28947285 )
2017
30
Extensive Pyoderma Gangrenosum: A Challenging Diagnosis and Literature Review of Management. ( 28944125 )
2017
31
Iliopsoas and intraperitoneal abscesses associated with pyoderma gangrenosum. ( 28869344 )
2017
32
Evaluation of C-reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs. ( 29168248 )
2017
33
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature. ( 28884797 )
2017
34
Successful treatment of a patient with myelodysplastic syndrome accompanied by pyoderma gangrenosum and BehAset's disease using allogeneic stem cell transplantation. ( 29333411 )
2017
35
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
36
Pyoderma Gangrenosum as the Initial Manifestation of Small Cell Lung Cancer with Dermatomyositis. ( 28836564 )
2017
37
Reconstructive microsurgical approach for the treatment of pyoderma gangrenosum. ( 28918934 )
2017
38
Non-response to Interleukin-1 Antagonist Canakinumab in Two Patients with Refractory Pyoderma Gangrenosum and Hidradenitis Suppurativa. ( 29344326 )
2017
39
Questionnaire survey of detrimental fur animal epidemic necrotic pyoderma in Finland. ( 28774326 )
2017
40
Pyoderma Gangrenosum: A Current Problem as Much as an Unknown One. ( 28915774 )
2017
41
Sporotrichosis masquerading as pyoderma gangrenosum. ( 28627095 )
2017
42
Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature. ( 28933699 )
2017
43
Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with hypogammaglobulinemia. ( 28815770 )
2017
44
Image Gallery: Pyoderma gangrenosum in a patient with myelodysplastic syndrome treated with azacitidine. ( 28940271 )
2017
45
Topical Medical Cannabis (TMC): A new treatment for wound pain-Three cases of Pyoderma Gangrenosum. ( 28818631 )
2017
46
Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum. ( 29264381 )
2017
47
Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab. ( 29447652 )
2017
48
A case of eosinophilic fasciitis associated with pyoderma gangrenosum. ( 28150344 )
2017
49
Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies. ( 29379508 )
2017
50
Successful treatment of pyoderma gangrenosum with anakinra in a patient with Wiskott-Aldrich syndrome. ( 29214738 )
2017

Variations for Pyoderma

Expression for Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for Pyoderma

Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 BTK CXCL8 IFNA2 IL1R1 ITGB2 MEFV
2
Show member pathways
13.02 CXCL8 IFNA2 IL1R1 ITGB2 MMP1 NOD2
3
Show member pathways
12.1 CXCL8 IL1R1 TNF
4
Show member pathways
12.1 BTK CXCL8 F3 IFNA2 IL1R1 MEFV
5
Show member pathways
12.02 CXCL8 IL1R1 TNF
6
Show member pathways
12.01 BTK CXCL8 ITGB2 MMP1 MMP10
7
Show member pathways
11.98 CXCL8 IFNA2 TNF
8 11.96 IFNA2 ITGB2 NOD2 TNF
9 11.9 CXCL8 IFNA2 TNF
10 11.87 BTK IL1R1 TNF
11 11.84 CXCL8 IL1R1 TNF
12
Show member pathways
11.81 MEFV NOD2 PSTPIP1
13 11.74 CXCL8 F3 TNF
14
Show member pathways
11.73 MMP1 MMP10 TNF
15 11.68 CXCL8 ITGB2 MMP1 TNF
16 11.6 CXCL8 ITGB2 TNF
17 11.54 CXCL8 IL1R1 ITGB2 TNF
18
Show member pathways
11.51 CXCL8 MMP1 TNF
19 11.49 CXCL8 MMP1 MMP10
20 11.43 BTK CXCL8 IL1R1 TNF
21 11.41 CXCL8 ITGB2 TNF
22 11.32 CXCL8 IL1R1 TNF
23 11.3 CXCL8 ITGB2 TNF
24 11.21 CXCL8 ITGB2 MMP1 TNF
25 11 CXCL8 TNF
26 10.98 NOD2 TNF
27 10.89 CXCL8 TNF

GO Terms for Pyoderma

Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH CXCL8 F3 IFNA2 IL1R1 MMP1
2 extracellular matrix GO:0031012 9.46 APOH F3 MMP1 MMP10
3 cell surface GO:0009986 9.1 APOH F3 IL1R1 ITGB2 NOD2 TNF

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.72 BTK IFNA2 MEFV NOD2 PSTPIP1
2 cytokine-mediated signaling pathway GO:0019221 9.63 F3 IFNA2 IL1R1
3 positive regulation of angiogenesis GO:0045766 9.61 CXCL8 F3 ITGB2
4 regulation of inflammatory response GO:0050727 9.54 IL1R1 NOD2 TNF
5 positive regulation of interleukin-8 production GO:0032757 9.49 NOD2 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.48 NOD2 TNF
7 defense response GO:0006952 9.46 CXCL8 IFNA2 NOD2 TNF
8 embryonic digestive tract development GO:0048566 9.4 CXCL8 TNF
9 cellular extravasation GO:0045123 9.26 ITGB2 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 BTK ITGB2 NOD2 TNF
11 inflammatory response GO:0006954 9.1 CXCL8 IFNA2 ITGB2 MEFV PSTPIP1 TNF

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 F3 IL1R1 TNF

Sources for Pyoderma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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