MCID: PYD001
MIFTS: 53

Pyoderma Gangrenosum malady

Skin, Bone categories

Summaries for Pyoderma Gangrenosum

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  each year in the united states, pyoderma gangrenosum occurs in about 1 person per 100.000 people. last updated: 4/26/2011

MalaCards: Pyoderma Gangrenosum is related to ulcerative colitis and acne, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, cutaneous rash and lung/pulmonary infiltrates. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs clofazimine and sulfapyridine pwdr and the compounds propylthiouracil and oxygen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and liver, and related mouse phenotype immune system.

Wikipedia:64 Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that... more...

Aliases & Classifications for Pyoderma Gangrenosum

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin, Bone


Characteristics (Orphanet epidemiological data):

49
pyoderma gangrenosum:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

pyoderma gangrenosum 8 43 10 45 49 61


External Ids:

Disease Ontology8 DOID:8553
ICD9CM27 686.01
MeSH35 D017511
ICD10 via Orphanet26 L88
SNOMED-CT57 74578003
SNOMED-CT via Orphanet58 74578003
UMLS via Orphanet62 C0085652
MESH via Orphanet36 D017511
ICD1025 L88

Related Diseases for Pyoderma Gangrenosum

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyoderma Gangrenosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.3NOD2, PRTN3, ITGB2, IL1R1
2acne31.1PSTPIP1
3arthritis31.1MEFV, MMP10, IL1R1, PRTN3, ITGB2, NOD2
4vasculitis30.8APOH, IFNA2, MEFV, ITGB2, PRTN3
5crohn's disease30.6NOD2
6acute leukemia30.5ITGB2, PRTN3, CSF3
7systemic lupus erythematosus30.5ITGB2, NOD2, IL1R1, PRTN3, APOH
8behcet's disease30.4MEFV, APOH, IFNA2
9adenocarcinoma30.4MMP26, MMP10, ITGB2
10splenomegaly30.4ITGB2, CSF3, IFNA2
11graves' disease30.2ITGB2
12urticaria30.2ITGB2, NLRP3
13retinal vasculitis30.2APOH
14wegener's granulomatosis30.2ITGB2, PRTN3
15polycythemia vera30.2IFNA2
16stomatitis30.2IFNA2, CSF3
17polyarteritis nodosa30.2PRTN3, MEFV, IFNA2
18tuberculosis30.2ITGB2, NOD2
19mycosis fungoides30.2IFNA2, ITGB2
20squamous cell carcinoma30.2PRTN3, IL1R1, MMP10, SERPINB13, ITGB2, MMP26
21hepatitis c30.2IFNA2, PRTN3, IL1R1
22pyogenic arthritis, pyoderma gangrenosum and acne10.7
23subcorneal pustular dermatosis10.6
24n syndrome10.6
25breast reconstruction10.5
26hidradenitis suppurativa10.5
27pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.5
28pyoderma gangrenosum - acne - suppurative hidradenitis10.5
29collagenous colitis10.4
30antiphospholipid syndrome10.4
31relapsing polychondritis10.4
32hepatitis e10.4
33leukocyte adhesion deficiency10.4
34necrotizing fasciitis10.4
35sporotrichosis10.4
36hepatitis a10.4
37chronic recurrent multifocal osteomyelitis10.4
38erythema elevatum diutinum10.4
39burns10.3
40sapho syndrome10.3
41cicatricial ectropion10.3
42common variable immunodeficiency10.3
43pemphigus10.3
44autoimmune hepatitis10.3
45ecthyma10.3
46agammaglobulinemia10.3
47acute febrile neutrophilic dermatosis10.3
48chronic myelomonocytic leukemia10.3
49septic shock10.3
50inflammatory bowel disease 210.3

Graphical network of the top 20 diseases related to Pyoderma Gangrenosum:



Diseases related to pyoderma gangrenosum

Clinical Features for Pyoderma Gangrenosum

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 8)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • lung/pulmonary infiltrates
  • myositis
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • dermal/subcutaneous infiltration/induration
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Pyoderma Gangrenosum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pyoderma Gangrenosum

Drug clinical trials:

Search ClinicalTrials for Pyoderma Gangrenosum

Search NIH Clinical Center for Pyoderma Gangrenosum

Search CenterWatch for Pyoderma Gangrenosum

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pyoderma Gangrenosum

Anatomical Context for Pyoderma Gangrenosum

Sources:
33MalaCards
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MalaCards organs/tissues related to Pyoderma Gangrenosum:

33
Bone marrow, Small intestine, Liver, Lung, Breast, Skin, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Pyoderma Gangrenosum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pyoderma Gangrenosum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5NOD2, IDS, CSF3, PSTPIP1, MEFV, ITGB2

Publications for Pyoderma Gangrenosum

Sources:
51PubMed
See all sources

Articles related to Pyoderma Gangrenosum:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Pyoderma gangrenosum with renal and splenic impairment - case report. (24346905)
2013
2
Pyoderma gangrenosum following foot and ankle surgery: a case report. (23637240)
2013
3
Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation. (22607468)
2013
4
Pyoderma gangrenosum with an underlying ulcerative colitis associated with bone tuberculosis. (23440150)
2013
5
Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine. (24252079)
2013
6
Treatment of atypical pyoderma gangrenosum on the face. (23898452)
2013
7
Pyoderma gangrenosum: an exceptional complication of venous access device. (24190068)
2013
8
Etiology and management of pyoderma gangrenosum: a comprehensive review. (22356259)
2012
9
Pyoderma gangrenosum associated with inflammatory bowel disease. Report of two cases with good response to infliximab. (22104047)
2012
10
Pyoderma gangrenosum with extensive perianal involvement. (22372804)
2012
11
Pyoderma gangrenosum after inguinal hernia repair. (21086145)
2012
12
Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne). (22161697)
2012
13
Can snus (Swedish moist snuff) be used as a treatment of Pyoderma gangrenosum? (22341940)
2012
14
Anterior cruciate ligament reconstruction complicated by pyoderma gangrenosum. (23131219)
2012
15
Progression of IgA gammopathy to myeloma following infliximab treatment for pyoderma gangrenosum. (22103549)
2012
16
Pyoderma gangrenosum, acne and suppurative hidradenitis syndrome following bowel bypass surgery. (23171584)
2012
17
Fatal pyoderma gangrenosum with pathergy after coronary artery bypass grafting. (23304049)
2012
18
Successful treatment of localized pyoderma gangrenosum with topical pimecrolimus. (22971301)
2012
19
Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum. (22281912)
2011
20
Pyoderma gangrenosum requiring inpatient management: a report of 26 cases with follow up. (21834821)
2011
21
Pyoderma gangrenosum heralding acute leukemia for months: diagnostic hint written on the skin. (21464419)
2011
22
Skin ulcer mimicking pyoderma gangrenosum in a patient with incontinentia pigmenti. (21972955)
2011
23
Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. (19846444)
2010
24
Leukocyte adhesion deficiency type 1 presenting with recurrent pyoderma gangrenosum and flaccid scarring. (20807363)
2010
25
Plasma cell-rich acute rejection after renal transplantation in a patient with pyoderma gangrenosum: a case report. (20590693)
2010
26
Pyoderma gangrenosum: a review and update on new therapies. (20227580)
2010
27
Pyoderma gangrenosum associated with subcorneal pustular dermatosis and IgA myeloma. (18627386)
2009
28
Atypical pyoderma gangrenosum presenting as paronychia. (19559153)
2009
29
Pyoderma gangrenosum: common pitfalls in management and a stepwise, evidence-based, therapeutic approach. (19480746)
2009
30
The clinical and histopathological description of geometric phagedenism (pyoderma gangrenosum) by Louis Brocq one century ago. (18559764)
2008
31
Delayed diagnosis of pyoderma gangrenosum: a case study. (19037135)
2008
32
Leukocyte adsorption apheresis for the treatment of pyoderma gangrenosum. (19239562)
2008
33
Negative pressure dressing in the management of pyoderma gangrenosum ulcer. (17938337)
2007
34
A case report of steroid and immunosuppressant-resistant pyoderma gangrenosum successfully treated by granulocytapheresis. (17845399)
2007
35
Efficacy of granulocyte and monocyte adsorption apheresis for three cases of refractory pyoderma gangrenosum. (17497998)
2007
36
Clonality in the setting of Sweet's syndrome and pyoderma gangrenosum is not limited to underlying myeloproliferative disease. (17576331)
2007
37
Use of infliximab in pyoderma gangrenosum. (17535196)
2007
38
Bullous pyoderma gangrenosum in acute myeloid leukaemia. (17419746)
2007
39
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. (17047113)
2006
40
Management of a chronic wound secondary to pyoderma gangrenosum following uncomplicated lower segment Caesarean section incision. (16441701)
2006
41
BehAset's disease-like presentation of bullous pyoderma gangrenosum associated with Crohn's disease. (16681583)
2006
42
Pyoderma gangrenosum. (17131965)
2006
43
Adverse reactions to gefitinib (Iressa): revealing sycosis- and pyoderma gangrenosum-like lesions. (16911406)
2006
44
Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome. (15916580)
2005
45
Infliximab for treatment of pyoderma gangrenosum associated with clinically inactive Crohn's disease. A case report. (16400359)
2005
46
Small joint monoarthritis and pyoderma gangrenosum in newly diagnosed ulcerative colitis: an unusual presentation. (17043551)
2004
47
Multiple lesions of pyoderma gangrenosum in association with hyper-reactive malarial splenomegaly. (15030358)
2004
48
Nodular scleritis in a patient with pyoderma gangrenosum. (12470160)
2002
49
Pyoderma gangrenosum in association with undifferentiated seronegative spondylarthropathy. (8651972)
1996
50
Fatal pyoderma gangrenosum in association with C7 deficiency. (1517503)
1992

Genetic Variations for Pyoderma Gangrenosum

Expression for genes affiliated with Pyoderma Gangrenosum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pyoderma Gangrenosum

Search GEO for disease gene expression data for Pyoderma Gangrenosum.

Pathways for genes affiliated with Pyoderma Gangrenosum

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems
See all sources

Compounds for genes affiliated with Pyoderma Gangrenosum

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 2 1112.6APOH
2oxygen45 2411.4PRTN3
3anakinra45 1111.3IL1R1, MVK, NLRP3
4hydroxychloroquine45 1111.2IL1R1, APOH, IFNA2
5etanercept45 50 1112.2IL1R1, APOH, IFNA2
6mevalonate4510.2NLRP3, MVK, MEFV, ITGB2
7colchicine60 45 2 29 1114.1IFNA2, MEFV, ITGB2
8ivig4510.1APOH, ITGB2, IL1R1
9thalidomide45 50 60 1113.0IFNA2, ITGB2, IL1R1
10cellulose4510.0IFNA2, IL1R1
11filgrastim45 1110.9CSF3, IFNA2
12n-formylmethionyl-leucylphenylalanine459.9PRTN3, ITGB2, CSF3
13gold459.9IFNA2, APOH, PRTN3, IL1R1
1412-o-tetradecanoylphorbol 13-acetate459.9MMP10, IL1R1, ITGB2, IFNA2
15methotrexate45 50 1111.8IL1R1, APOH, CSF3, NLRP3
16infliximab45 50 1111.8IFNA2, APOH, PRTN3, IL1R1, NOD2
17azathioprine45 50 2 1112.8PRTN3, APOH, IFNA2
18procainamide45 1110.7ITGB2, APOH
19cyclophosphamide45 50 1111.7IFNA2, CSF3, APOH, ITGB2, IL1R1
20fibrinogen459.7APOH, ITGB2, IL1R1, MMP26
21rituximab45 50 1111.6IFNA2, CSF3, APOH, PRTN3, IL1R1
22endotoxin459.6CSF3, APOH, MEFV, ITGB2, IL1R1, NOD2
23prednisolone45 29 1111.5NOD2, IL1R1, ITGB2, APOH, CSF3, IFNA2
24superoxide45 2410.5IFNA2, CSF3, APOH, ITGB2, PRTN3
25vegf459.5IFNA2, CSF3, APOH, ITGB2, IL1R1, MMP10
26cysteine459.3IDS, IFNA2, GUCA1A, ITGB2, IL1R1, SERPINB13
27serine459.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
28retinoic acid45 2410.2IFNA2, CSF3, ITGB2, PRTN3, IL1R1, MMP26
29calcium45 50 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, IL1R1

GO Terms for genes affiliated with Pyoderma Gangrenosum

Sources:
16Gene Ontology
See all sources

Biological processes related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.3NLRP3, NOD2
2positive regulation of interleukin-1 beta secretionGO:05071810.2NLRP3, NOD2
3negative regulation of inflammatory responseGO:05072810.1MEFV, MVK, NLRP3
4negative regulation of interleukin-12 productionGO:03269510.1MEFV, NOD2
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.0PSTPIP1, MEFV, NOD2, NLRP3
6collagen catabolic processGO:0305749.8PRTN3, MMP10, MMP26
7inflammatory responseGO:0069549.4MEFV, IFNA2, NLRP3, ITGB2
8innate immune responseGO:0450879.4PSTPIP1, C7, NOD2, ITGB2, MEFV, NLRP3

Molecular functions related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma Gangrenosum

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyoderma Gangrenosum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet