MCID: PYD001
MIFTS: 57

Pyoderma Gangrenosum malady

Skin diseases, Bone diseases categories

Summaries for Pyoderma Gangrenosum

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  each year in the united states, pyoderma gangrenosum occurs in about 1 person per 100.000 people. last updated: 4/26/2011

MalaCards: Pyoderma Gangrenosum is related to ulcerative colitis and inflammatory bowel disease, and has symptoms including subcutaneous nodules/lipomas/tumefaction/swelling, erythema/erythematous lesions/erythroderma/polymorphous erythema and dermal/subcutaneous infiltration/induration. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs clofazimine and sulfapyridine pwdr and the compounds propylthiouracil and oxygen have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related mouse phenotype immune system.

Wikipedia:63 Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that... more...

Aliases & Classifications for Pyoderma Gangrenosum

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
pyoderma gangrenosum:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

pyoderma gangrenosum 8 42 10 44 48 60


External Ids:

Disease Ontology8 DOID:8553
ICD9CM27 686.01
MeSH34 D017511
ICD10 via Orphanet26 L88
SNOMED-CT56 74578003
SNOMED-CT via Orphanet57 74578003
UMLS via Orphanet61 C0085652
MESH via Orphanet35 D017511
ICD1025 L88

Related Diseases for Pyoderma Gangrenosum

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyoderma Gangrenosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.2ITGB2, PRTN3, IL1R1, NOD2
2inflammatory bowel disease31.1PSTPIP1, ITGB2, PRTN3, IL1R1, NOD2
3acne31.1PSTPIP1
4arthritis31.0NLRP3, MVK, PSTPIP1, MEFV, ITGB2, PRTN3
5crohn's disease31.0NOD2
6vasculitis30.8PRTN3, ITGB2, MEFV, APOH, IFNA2
7rheumatoid arthritis30.7APOH, MEFV, ITGB2, PRTN3, IL1R1, NOD2
8leukemia30.6IDS, IFNA2, CSF3, ITGB2, PRTN3, IL1R1
9hepatitis30.6IFNA2
10dermatitis30.6NLRP3, ITGB2, NOD2
11psoriasis30.6SERPINB13, NOD2, IL1R1, ITGB2
12lupus erythematosus30.5APOH, IFNA2
13behcet's disease30.5MEFV, APOH, IFNA2
14acute leukemia30.5PRTN3, ITGB2, CSF3
15systemic lupus erythematosus30.5NOD2, IL1R1, PRTN3, ITGB2, APOH
16adenocarcinoma30.3MMP26, MMP10, ITGB2
17neutropenia30.3IFNA2, CSF3, PRTN3
18hepatitis c30.3IL1R1, PRTN3, IFNA2
19sarcoidosis30.1NOD2
20graves' disease30.1ITGB2
21ischemia30.1ITGB2
22pneumonia30.1CSF3
23urticaria30.1ITGB2, NLRP3
24multiple sclerosis30.1ITGB2, IL1R1
25retinal vasculitis30.1APOH
26wegener's granulomatosis30.1PRTN3, ITGB2
27polycythemia vera30.1IFNA2
28stomatitis30.1IFNA2, CSF3
29polyarteritis nodosa30.1PRTN3, MEFV, IFNA2
30glomerulonephritis30.1IL1R1, PRTN3, ITGB2
31tuberculosis30.1NOD2, ITGB2
32mycosis fungoides30.1ITGB2, IFNA2
33squamous cell carcinoma30.1SERPINB13, MMP26, MMP10, IL1R1, PRTN3, ITGB2
34pyoderma11.5
35pyogenic arthritis, pyoderma gangrenosum and acne10.6
36hidradenitis10.6
37breast reconstruction10.5
38subcorneal pustular dermatosis10.5
39hidradenitis suppurativa10.5
40takayasu's arteritis10.5
41myeloma10.5
42pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.5
43cutaneous t cell lymphoma10.4
44antiphospholipid syndrome10.3
45relapsing polychondritis10.3
46leukocyte adhesion deficiency10.3
47necrotizing fasciitis10.3
48sporotrichosis10.3
49fasciitis10.3
50osteomyelitis10.3

Graphical network of the top 20 diseases related to Pyoderma Gangrenosum:



Diseases related to pyoderma gangrenosum

Clinical Features for Pyoderma Gangrenosum

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48Orphanet
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Symptoms:

48 (show all 8)
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • dermal/subcutaneous infiltration/induration
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • myositis
  • lung/pulmonary infiltrates
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum

Drugs & Therapeutics for Pyoderma Gangrenosum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pyoderma Gangrenosum

Drug clinical trials:

Search ClinicalTrials for Pyoderma Gangrenosum

Search NIH Clinical Center for Pyoderma Gangrenosum

Search CenterWatch for Pyoderma Gangrenosum

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pyoderma Gangrenosum

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Anatomical Context for Pyoderma Gangrenosum

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32MalaCards
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MalaCards organs/tissues related to Pyoderma Gangrenosum:

32
Skin, Breast, Lung, Bone, T cells, Myeloid, Monocytes, Bone marrow, Prostate, Liver, Endothelial

Animal Models for Pyoderma Gangrenosum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyoderma Gangrenosum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5NOD2, IDS, CSF3, PSTPIP1, MEFV, ITGB2

Publications for Pyoderma Gangrenosum

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Sources:
50PubMed
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Articles related to Pyoderma Gangrenosum:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Concurrent hidradenitis suppurativa, inflammatory acne, dissecting cellulitis of the scalp, and pyoderma gangrenosum in a 16-year-old boy. (24118007)
2014
2
Genital pyoderma gangrenosum: report of two cases and published work review of Japanese cases. (24033392)
2013
3
Necrotizing vasculitis secondary to disseminated histoplasmosis simulating pyoderma gangrenosum. (23661428)
2013
4
Postoperative pathergic pyoderma gangrenosum after aortic aneurysm repair. (24164156)
2013
5
Characteristics and treatment of pyoderma gangrenosum in inflammatory bowel disease. (23828140)
2013
6
Familial pyoderma gangrenosum in association with common variable immunodeficiency. (23662950)
2013
7
Idiopathic myelofibrosis and pyoderma gangrenosum involving a mutation of Janus kinase 2 (JAK2V617F), showing poor prognosis. (23557850)
2013
8
Vulvar pyoderma gangrenosum originating from a healed obstetric laceration. (23884257)
2013
9
Treatment of a relapsing facial pyoderma gangrenosum (malignant pyoderma). (23330662)
2013
10
Auricular pyoderma gangrenosum associated with Crohn's disease. (22585655)
2012
11
Propylthiouracil-induced antineutrophil cytoplasmic antibody positive vasculitis clinically mimicking pyoderma gangrenosum. (22132781)
2012
12
Successful treatment with infliximab for refractory pyoderma gangrenosum associated with inflammatory bowel disease. (21958000)
2012
13
Bullous pyoderma gangrenosum of the bilateral dorsal hands. (23039059)
2012
14
Staged correction of an equinovarus deformity due to pyoderma gangrenosum using a Taylor spatial frame and tibiotalar calcaneal fusion with an intramedullary device. (21863298)
2011
15
Pyoderma gangrenosum associated with renal carcinoma. (21571198)
2011
16
Management of peristomal pyoderma gangrenosum--two different approaches for the same clinical problem. (21922887)
2011
17
Eosinophilic pyoderma gangrenosum with pulmonary and oral lesions preceded by eosinophilic pneumonia: Unrecognized syndromic manifestations? (21700533)
2011
18
Clinical features of pyoderma gangrenosum and current diagnostic trends. (21292348)
2011
19
Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumab. (20804692)
2010
20
A novel approach to the management of pyoderma gangrenosum complicating reduction mammaplasty. (20442095)
2010
21
Case report: pyoderma gangrenosum following Deep Inferior Epigastric Perforator (Diep) free flap breast reconstruction. (19926352)
2010
22
Necrotizing pyoderma gangrenosum: an unusual differential diagnosis of necrotizing fasciitis. (20202917)
2010
23
Pyoderma gangrenosum after bone marrow transplantation for leukocyte adhesion deficiency type 1. (20550039)
2010
24
Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum: Two birds with one stone. (19437575)
2009
25
Pyoderma gangrenosum with myelodysplastic syndrome treated with analogous bone marrow transplantation. (19197560)
2009
26
Successful treatment of pyoderma gangrenosum associated with juvenile idiopathic arthritis with a combination of topical tacrolimus and oral prednisolone. (19189166)
2009
27
Iatrogenic pyoderma gangrenosum following iodine-containing contrast media. (19522901)
2009
28
Postoperative pyoderma gangrenosum: diagnostic value of 16s ribosomal RNA sequencing and review of the literature. (19094123)
2009
29
FK-506 ointment: an effective adjuvant therapy to treat a dramatic case of pyoderma gangrenosum of unilateral hand. (19486563)
2009
30
Port-site pyoderma gangrenosum - a rare complication of surgical trauma. (19558786)
2009
31
Analgesic effect of locally applied morphine to pyoderma gangrenosum. (19076804)
2009
32
Subungual pyoderma gangrenosum complicated by myopathy induced by ciclosporin and tacrolimus. (19236429)
2009
33
Traumatic pyoderma gangrenosum of the face: pathergy development after bike accident. (19060470)
2009
34
Cutaneous microangiopathic thrombosis complicated by pyoderma gangrenosum in post-cardiac surgery heparin-induced thrombocytopaenia. (18375181)
2009
35
An open-label pilot study of alefacept for the treatment of pyoderma gangrenosum. (18384543)
2008
36
Successful treatment of severe pyoderma gangrenosum with pimecrolimus cream 1%. (18181988)
2008
37
Infantile pyoderma gangrenosum. (18191692)
2008
38
Treatment of idiopathic pyoderma gangrenosum with infliximab: induction dosing regimen or on-demand therapy? (18216480)
2008
39
Dermatitis artefacta masquerading as pyoderma gangrenosum. (18937670)
2008
40
Pyoderma gangrenosum treated with infliximab in inactive ulcerative colitis. (18401859)
2008
41
Pyoderma gangrenosum in the head and neck. (17224531)
2007
42
Pyoderma gangrenosum--a review. (17433111)
2007
43
Diagnostic dilemma between intestinal BehAset disease and inflammatory bowel disease with pyoderma gangrenosum. (17007037)
2006
44
CD30+ anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines. (16923111)
2006
45
Pyoderma gangrenosum complicating pegylated granulocyte colony-stimulating factor in Hodgkin lymphoma. (16371028)
2006
46
Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum. (17179573)
2006
47
Pyoderma gangrenosum in a syringe driver site of a patient with non-Hodgkin's lymphoma. (16615193)
2006
48
Pyoderma gangrenosum as first clinical manifestation of gastric adenocarcinoma. (16643144)
2006
49
Pyoderma gangrenosum followed by subcorneal pustular dermatosis in a patient with IgA paraproteinemia. (1999540)
1991
50
Cutaneous vasculitis, hypersensitivity vasculitis, erythema nodosum, and pyoderma gangrenosum. (2043448)
1991

Genetic Variations for Pyoderma Gangrenosum

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Expression for genes affiliated with Pyoderma Gangrenosum

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyoderma Gangrenosum

Search GEO for disease gene expression data for Pyoderma Gangrenosum.

Pathways for genes affiliated with Pyoderma Gangrenosum

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Pyoderma Gangrenosum

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.6APOH
2oxygen44 2411.4PRTN3
3anakinra44 1111.3IL1R1, MVK, NLRP3
4hydroxychloroquine44 1111.2IL1R1, APOH, IFNA2
5etanercept44 49 1112.2IL1R1, APOH, IFNA2
6mevalonate4410.2NLRP3, MVK, MEFV, ITGB2
7colchicine59 44 2 28 1114.1IFNA2, MEFV, ITGB2
8ivig4410.1APOH, ITGB2, IL1R1
9thalidomide44 49 59 1113.0IFNA2, ITGB2, IL1R1
10cellulose4410.0IFNA2, IL1R1
11filgrastim44 1110.9CSF3, IFNA2
12n-formylmethionyl-leucylphenylalanine449.9PRTN3, ITGB2, CSF3
13gold449.9IFNA2, APOH, PRTN3, IL1R1
1412-o-tetradecanoylphorbol 13-acetate449.9MMP10, IL1R1, ITGB2, IFNA2
15methotrexate44 49 1111.8IL1R1, APOH, CSF3, NLRP3
16infliximab44 49 1111.8IFNA2, APOH, PRTN3, IL1R1, NOD2
17azathioprine44 49 2 1112.8PRTN3, APOH, IFNA2
18procainamide44 1110.7ITGB2, APOH
19cyclophosphamide44 49 1111.7IFNA2, CSF3, APOH, ITGB2, IL1R1
20fibrinogen449.7APOH, ITGB2, IL1R1, MMP26
21rituximab44 49 1111.6IFNA2, CSF3, APOH, PRTN3, IL1R1
22endotoxin449.6CSF3, APOH, MEFV, ITGB2, IL1R1, NOD2
23prednisolone44 28 1111.5NOD2, IL1R1, ITGB2, APOH, CSF3, IFNA2
24superoxide44 2410.5IFNA2, CSF3, APOH, ITGB2, PRTN3
25vegf449.5IFNA2, CSF3, APOH, ITGB2, IL1R1, MMP10
26cysteine449.3IDS, IFNA2, GUCA1A, ITGB2, IL1R1, SERPINB13
27serine449.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
28retinoic acid44 2410.2IFNA2, CSF3, ITGB2, PRTN3, IL1R1, MMP26
29calcium44 49 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, IL1R1

GO Terms for genes affiliated with Pyoderma Gangrenosum

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16Gene Ontology
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Biological processes related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.3NOD2, NLRP3
2positive regulation of interleukin-1 beta secretionGO:05071810.2NOD2, NLRP3
3negative regulation of inflammatory responseGO:05072810.1NLRP3, MVK, MEFV
4negative regulation of interleukin-12 productionGO:03269510.1NOD2, MEFV
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.0NOD2, MEFV, PSTPIP1, NLRP3
6collagen catabolic processGO:0305749.8MMP26, MMP10, PRTN3
7inflammatory responseGO:0069549.4NLRP3, IFNA2, MEFV, ITGB2
8innate immune responseGO:0450879.4NLRP3, IFNA2, PSTPIP1, MEFV, ITGB2, NOD2

Molecular functions related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma Gangrenosum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyoderma Gangrenosum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet