MCID: PYD001
MIFTS: 57

Pyoderma Gangrenosum malady

Skin diseases, Bone diseases categories

Summaries for Pyoderma Gangrenosum

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  each year in the united states, pyoderma gangrenosum occurs in about 1 person per 100.000 people. last updated: 4/26/2011

MalaCards: Pyoderma Gangrenosum is related to ulcerative colitis and inflammatory bowel disease, and has symptoms including lung/pulmonary infiltrates, myositis and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), and among its related pathways are Inflammasomes and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs clofazimine and sulfapyridine pwdr and the compounds propylthiouracil and oxygen have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related mouse phenotype immune system.

Wikipedia:63 Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that... more...

Aliases & Classifications for Pyoderma Gangrenosum

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
pyoderma gangrenosum:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

pyoderma gangrenosum 8 42 10 44 48 60


External Ids:

Disease Ontology8 DOID:8553
ICD9CM27 686.01
MeSH34 D017511
ICD10 via Orphanet26 L88
SNOMED-CT56 74578003
SNOMED-CT via Orphanet57 74578003
UMLS via Orphanet61 C0085652
MESH via Orphanet35 D017511
ICD1025 L88

Related Diseases for Pyoderma Gangrenosum

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pyoderma Gangrenosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.2ITGB2, PRTN3, IL1R1, NOD2
2inflammatory bowel disease31.1PSTPIP1, ITGB2, PRTN3, IL1R1, NOD2
3acne31.1PSTPIP1
4arthritis31.0NLRP3, MVK, PSTPIP1, MEFV, ITGB2, PRTN3
5crohn's disease31.0NOD2
6vasculitis30.8PRTN3, ITGB2, MEFV, APOH, IFNA2
7rheumatoid arthritis30.7APOH, MEFV, ITGB2, PRTN3, IL1R1, NOD2
8leukemia30.6IDS, IFNA2, CSF3, ITGB2, PRTN3, IL1R1
9hepatitis30.6IFNA2
10dermatitis30.6NLRP3, ITGB2, NOD2
11psoriasis30.6SERPINB13, NOD2, IL1R1, ITGB2
12lupus erythematosus30.5APOH, IFNA2
13behcet's disease30.5MEFV, APOH, IFNA2
14acute leukemia30.5PRTN3, ITGB2, CSF3
15systemic lupus erythematosus30.5NOD2, IL1R1, PRTN3, ITGB2, APOH
16adenocarcinoma30.3MMP26, MMP10, ITGB2
17neutropenia30.3IFNA2, CSF3, PRTN3
18hepatitis c30.3IL1R1, PRTN3, IFNA2
19sarcoidosis30.1NOD2
20graves' disease30.1ITGB2
21ischemia30.1ITGB2
22pneumonia30.1CSF3
23urticaria30.1ITGB2, NLRP3
24multiple sclerosis30.1ITGB2, IL1R1
25retinal vasculitis30.1APOH
26wegener's granulomatosis30.1PRTN3, ITGB2
27polycythemia vera30.1IFNA2
28stomatitis30.1IFNA2, CSF3
29polyarteritis nodosa30.1PRTN3, MEFV, IFNA2
30glomerulonephritis30.1IL1R1, PRTN3, ITGB2
31tuberculosis30.1NOD2, ITGB2
32mycosis fungoides30.1ITGB2, IFNA2
33squamous cell carcinoma30.1SERPINB13, MMP26, MMP10, IL1R1, PRTN3, ITGB2
34pyoderma11.5
35pyogenic arthritis, pyoderma gangrenosum and acne10.6
36hidradenitis10.6
37breast reconstruction10.5
38subcorneal pustular dermatosis10.5
39hidradenitis suppurativa10.5
40takayasu's arteritis10.5
41myeloma10.5
42pyogenic sterile arthritis, pyoderma gangrenosum, and acne10.5
43cutaneous t cell lymphoma10.4
44antiphospholipid syndrome10.3
45relapsing polychondritis10.3
46leukocyte adhesion deficiency10.3
47necrotizing fasciitis10.3
48sporotrichosis10.3
49fasciitis10.3
50osteomyelitis10.3

Graphical network of the top 20 diseases related to Pyoderma Gangrenosum:



Diseases related to pyoderma gangrenosum

Clinical Features for Pyoderma Gangrenosum

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48Orphanet
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Symptoms:

48 (show all 8)
  • lung/pulmonary infiltrates
  • myositis
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • dermal/subcutaneous infiltration/induration

Drugs & Therapeutics for Pyoderma Gangrenosum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pyoderma Gangrenosum

Drug clinical trials:

Search ClinicalTrials for Pyoderma Gangrenosum

Search NIH Clinical Center for Pyoderma Gangrenosum

Search CenterWatch for Pyoderma Gangrenosum

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pyoderma Gangrenosum

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Anatomical Context for Pyoderma Gangrenosum

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32MalaCards
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MalaCards organs/tissues related to Pyoderma Gangrenosum:

32
Skin, Breast, Lung, Bone, T cells, Myeloid, Monocytes, Bone marrow, Endothelial, Liver, Prostate

Animal Models for Pyoderma Gangrenosum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyoderma Gangrenosum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5NOD2, IDS, CSF3, PSTPIP1, MEFV, ITGB2

Publications for Pyoderma Gangrenosum

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Sources:
50PubMed
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Articles related to Pyoderma Gangrenosum:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Penile pyoderma gangrenosum. (24339469)
2013
2
Inpatient Management of Pyoderma Gangrenosum: Treatments, Outcomes, and Clinical Implications. (23903083)
2013
3
Pyoderma Gangrenosum Associated with an Aseptic Splenic Abscess in a Patient with Neurofibromatosis. (23535023)
2013
4
Treatment of pyoderma gangrenosum with mycophenolate mofetil as a steroid-sparing agent. (23850090)
2013
5
Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet's syndrome: the concept of neutrophilic disease. (24073904)
2013
6
Treatment of pyoderma gangrenosum with topical factor XIII. (24135449)
2013
7
Pyoderma Gangrenosum: The role of surgical treatment. (23750374)
2013
8
Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. (22534879)
2012
9
Pyoderma gangrenosum: a new complication after groin exposure for attempted endovascular aortic stent-graft placement. (21885476)
2012
10
Skin ulcers mimicking pyoderma gangrenosum in a patient with MTHFR polymorphism. (23158641)
2012
11
Penile pyoderma gangrenosum successfully treated with topical Imiquimod. (22021975)
2011
12
Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum. (21790734)
2011
13
Coexistent pyoderma gangrenosum and tibialis anterior myositis as presenting manifestations of Crohn's disease: case report and review of the literature. (19847433)
2011
14
Coexistence of fatal disseminated invasive aspergillosis and pyoderma gangrenosum: a case report. (21577002)
2011
15
Pyoderma gangrenosum-like lesions in leukocyte adhesion deficiency I treated with intravenous immunoglobulin. (21366684)
2011
16
Pyoderma gangrenosum following surgical procedures. (20465683)
2010
17
Unusual association between autoimmune hepatitis and severe pyoderma gangrenosum. (19590450)
2010
18
Pyoderma gangrenosum responding to ciclosporin without adverse effects in a patient with lymphomatoid papulosis. (20456406)
2010
19
Pyoderma gangrenosum associated with SjAPgren syndrome. (19467964)
2009
20
Systemic polyarteritis nodosa mimicking pyoderma gangrenosum in a rare association with small lymphocytic leukaemia/chronic lymphocytic leukaemia. (19438540)
2009
21
Reduction of interleukin-6, interleukin-8, and anti-phosphatidylserine-prothrombin complex antibody by granulocyte and monocyte adsorption apheresis in a patient with pyoderma gangrenosum and ulcerative colitis. (19727102)
2009
22
Pyoderma gangrenosum after abdominal surgery--a rare but none the less necessary differential diagnosis. (19603173)
2009
23
Treatment of refractory pyoderma gangrenosum with intravenous immunoglobulin. (19178495)
2009
24
Development of pyoderma gangrenosum during therapy with infliximab. (21886723)
2009
25
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome): report of a sporadic case without an identifiable mutation in the CD2BP1 gene. (19700023)
2009
26
A novel therapy for the treatment of pyoderma gangrenosum. (18935734)
2008
27
Primary pyoderma gangrenosum of the lungs. (19119117)
2008
28
Pyoderma gangrenosum and ulcerative colitis in the tropics. (19142449)
2008
29
Maggots do not survive in pyoderma gangrenosum. (18663307)
2008
30
Pyoderma gangrenosum manifesting as a cavitating lung lesion. (18498409)
2008
31
Bird-bite infection and pyoderma gangrenosum: a rare combination? (18676192)
2008
32
Intravenous immunoglobulin is effective as a sole immunomodulatory agent in pyoderma gangrenosum unresponsive to systemic corticosteroids. (17342799)
2007
33
Successful treatment with infliximab of refractory pyoderma gangrenosum in 2 patients with inflammatory bowel diseases. (17508417)
2007
34
Treatment of pyoderma gangrenosum with intravenous immunoglobulin. (17916196)
2007
35
A case of pyoderma gangrenosum responding to high-dose intravenous immunoglobulin therapy. (16863619)
2006
36
Pyoderma gangrenosum preceding the onset of cutaneous T-cell lymphoma. (16487114)
2006
37
Diagnosis and treatment of pyoderma gangrenosum. (16858047)
2006
38
Intestinal Behcet's disease with pyoderma gangrenosum: a case report. (16521233)
2006
39
Infantile Crohn disease presenting with diarrhea and pyoderma gangrenosum. (16445411)
2006
40
Prostatic infarction involving the urinary sphincter, an association with pyoderma gangrenosum. (16417963)
2006
41
Pyoderma gangrenosum in association with juvenile rheumatoid arthritis. (16361736)
2005
42
Pyoderma gangrenosum associated with hidradenitis suppurativa. (16197385)
2005
43
Pyoderma gangrenosum in a patient with collagenous colitis. (14576653)
2003
44
Skin ulcers associated with a tender and swollen arm. Pyoderma gangrenosum (PG) in association with chronic recurrent multifocal osteomyelitis (CRMO). (9762031)
1998
45
Pyoderma gangrenosum and subcorneal pustular dermatosis: clues to underlying immunoglobulin A myeloma. (8678088)
1996
46
Klippel-Trenaunay-Weber syndrome mimicking pyoderma gangrenosum. (8537163)
1995
47
Bullous pyoderma gangrenosum after granulocyte colony-stimulating factor treatment. (1712666)
1991
48
Pyoderma gangrenosum versus acute febrile neutrophilic dermatosis (Sweet's syndrome) (3674086)
1987
49
Pyoderma gangrenosum, subcorneal pustular dermatosis and IgA paraproteinaemia. (3510651)
1986
50
Acute febrile neutrophilic dermatosis (Sweet's syndrome) and the related conditions of "bowel bypass" syndrome and bullous pyoderma gangrenosum. (3912087)
1985

Genetic Variations for Pyoderma Gangrenosum

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Expression for genes affiliated with Pyoderma Gangrenosum

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyoderma Gangrenosum

Search GEO for disease gene expression data for Pyoderma Gangrenosum.

Pathways for genes affiliated with Pyoderma Gangrenosum

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Pyoderma Gangrenosum

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.6APOH
2oxygen44 2411.4PRTN3
3anakinra44 1111.3IL1R1, MVK, NLRP3
4hydroxychloroquine44 1111.2IL1R1, APOH, IFNA2
5etanercept44 49 1112.2IL1R1, APOH, IFNA2
6mevalonate4410.2NLRP3, MVK, MEFV, ITGB2
7colchicine59 44 2 28 1114.1IFNA2, MEFV, ITGB2
8ivig4410.1APOH, ITGB2, IL1R1
9thalidomide44 49 59 1113.0IFNA2, ITGB2, IL1R1
10cellulose4410.0IFNA2, IL1R1
11filgrastim44 1110.9CSF3, IFNA2
12n-formylmethionyl-leucylphenylalanine449.9PRTN3, ITGB2, CSF3
13gold449.9IFNA2, APOH, PRTN3, IL1R1
1412-o-tetradecanoylphorbol 13-acetate449.9MMP10, IL1R1, ITGB2, IFNA2
15methotrexate44 49 1111.8IL1R1, APOH, CSF3, NLRP3
16infliximab44 49 1111.8IFNA2, APOH, PRTN3, IL1R1, NOD2
17azathioprine44 49 2 1112.8PRTN3, APOH, IFNA2
18procainamide44 1110.7ITGB2, APOH
19cyclophosphamide44 49 1111.7IFNA2, CSF3, APOH, ITGB2, IL1R1
20fibrinogen449.7APOH, ITGB2, IL1R1, MMP26
21rituximab44 49 1111.6IFNA2, CSF3, APOH, PRTN3, IL1R1
22endotoxin449.6CSF3, APOH, MEFV, ITGB2, IL1R1, NOD2
23prednisolone44 28 1111.5NOD2, IL1R1, ITGB2, APOH, CSF3, IFNA2
24superoxide44 2410.5IFNA2, CSF3, APOH, ITGB2, PRTN3
25vegf449.5IFNA2, CSF3, APOH, ITGB2, IL1R1, MMP10
26cysteine449.3IDS, IFNA2, GUCA1A, ITGB2, IL1R1, SERPINB13
27serine449.3MVK, PSTPIP1, ITGB2, PRTN3, IL1R1, MMP10
28retinoic acid44 2410.2IFNA2, CSF3, ITGB2, PRTN3, IL1R1, MMP26
29calcium44 49 11 2411.9IDS, APOH, GUCA1A, ITGB2, PRTN3, IL1R1

GO Terms for genes affiliated with Pyoderma Gangrenosum

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16Gene Ontology
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Biological processes related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1detection of biotic stimulusGO:00959510.3NLRP3, NOD2
2positive regulation of interleukin-1 beta secretionGO:05071810.2NLRP3, NOD2
3negative regulation of inflammatory responseGO:05072810.1MEFV, MVK, NLRP3
4negative regulation of interleukin-12 productionGO:03269510.1MEFV, NOD2
5nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.0PSTPIP1, MEFV, NOD2, NLRP3
6collagen catabolic processGO:0305749.8PRTN3, MMP10, MMP26
7inflammatory responseGO:0069549.4MEFV, IFNA2, NLRP3, ITGB2
8innate immune responseGO:0450879.4PSTPIP1, C7, NOD2, ITGB2, MEFV, NLRP3

Molecular functions related to Pyoderma Gangrenosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.2NOD2, NLRP3

Products for genes affiliated with Pyoderma Gangrenosum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pyoderma Gangrenosum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet