MCID: PYD001
MIFTS: 48

Pyoderma Gangrenosum malady

Categories: Rare diseases, Skin diseases, Bone diseases

Aliases & Classifications for Pyoderma Gangrenosum

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Pyoderma Gangrenosum:

Name: Pyoderma Gangrenosum 11 46 13 52 48 37 66

Characteristics:

Orphanet epidemiological data:

52
pyoderma gangrenosum:
Prevalence: 1-9/100000 (United States),1-9/1000000 (United Kingdom),1-9/1000000 (Spain),1-9/1000000 (Worldwide); Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:8553
ICD1028 L88
ICD9CM30 686.01
MeSH37 D017511
SNOMED-CT60 74578003
Orphanet52 ORPHA48104
ICD10 via Orphanet29 L88
MESH via Orphanet38 D017511
UMLS via Orphanet67 C0085652

Summaries for Pyoderma Gangrenosum

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NIH Rare Diseases:46 Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, vasculitis, leukemia, and other conditions. each year in the united states, pyoderma gangrenosum occurs in about 1 person per 100,000 people. pyoderma gangrenosum belongs to a group of autoinflammatory skin diseases called neutrophilic dermatoses. neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections. ulcerations associated with pyoderma gangrenosum may occur after trauma or injury to the skin, a process called pathergy. treatment involves wound care and the use of anti-inflammatory agents, including antibiotics, corticosteroids, immunosuppressants, and biologics.  last updated: 8/15/2016

MalaCards based summary: Pyoderma Gangrenosum is related to burns and skin disease, and has symptoms including skin rash, pulmonary infiltrates and myositis. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways are EBV LMP1 signaling and Immune response_MIF-mediated glucocorticoid regulation. The drugs clofazimine and sulfapyridine pwdr have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and breast, and related mouse phenotype immune system.

Wikipedia:69 Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that... more...

Related Diseases for Pyoderma Gangrenosum

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Diseases related to Pyoderma Gangrenosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1burns30.5CXCL8, TNF
2skin disease30.2CXCL8, TNF
3malakoplakia29.8CXCL8, MMP9
4microscopic colitis29.1CXCL8, NOD2, TNF
5rheumatoid arthritis29.0CXCL8, IL1R1, ITGB2, MMP9, TNF
6pyogenic sterile arthritis, pyoderma gangrenosum, and acne12.5
7pyogenic arthritis, pyoderma gangrenosum and acne12.4
8pyoderma gangrenosum-acne-suppurative hidradenitis syndrome12.2
9pyoderma11.6
10crohn's disease10.9
11zori stalker williams syndrome10.7IL1R1, PSTPIP1
12warm antibody hemolytic anemia10.6IL1R1, TNF
13astrocytoma10.6IL1R1, TNF
14colitis10.6
15mixed connective tissue disease10.6IL1R1, TNF
16ulcerative colitis10.6
17primary biliary cirrhosis10.5IL1R1, TNF
18acne10.5
19loin pain hematuria syndrome10.5ITGB2, TNF
20arthritis10.5
21keloids10.5IL1R1, TNF
22large cell carcinoma with rhabdoid phenotype10.4MMP9, TNF
23pyloric stenosis, infantile hypertrophic, 210.4PSTPIP1, TNF
24leukoplakia10.4IL1R1, TNF
25hidradenitis10.4
26basidiobolomycosis10.4CXCL8, TNF
27lymphoma10.4
28maligant granulosa cell tumor of ovary10.4CXCL8, TNF
29addison's disease10.3CXCL8, TNF
303-alpha hydroxyacyl-coa dehydrogenase deficiency10.3CXCL8, TNF
31myelodysplastic syndrome10.3
32pasteurellosis10.3CXCL8, TNF
33t-cell lymphoma 1a10.3CXCL8, TNF
34paraphimosis10.3CXCL8, TNF
35uterus carcinoma in situ10.3CXCL8, PSTPIP1
36qualitative platelet defect10.3CXCL8, TNF
37mycobacterium fortuitum10.3CXCL8, TNF
38chorioretinitis10.3MMP9, TNF
39orbital lymphangioma10.3CXCL8, TNF
40pseudoretinitis pigmentosa10.3CXCL8, TNF
41paraneoplastic polyneuropathy10.3CXCL8, TNF
42mechanical lagophthalmos10.3CXCL8, TNF
43oral candidiasis10.3CXCL8, TNF
44hidradenitis suppurativa10.3
45vasculitis10.3
46breast reconstruction10.2
47hepatitis10.2
48subcorneal pustular dermatosis10.2
49ileocolitis10.2
50inner ear cancer10.2CXCL8, TNF

Graphical network of the top 20 diseases related to Pyoderma Gangrenosum:



Diseases related to pyoderma gangrenosum

Symptoms for Pyoderma Gangrenosum

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Symptoms:

 52 (show all 15)
  • atrophic scars
  • rheumatoid arthritis
  • fever
  • inflammation of the large intestine
  • arthralgia
  • myelodysplasia
  • myalgia
  • abnormal blistering of the skin
  • hypergammaglobulinemia
  • myeloid leukemia
  • myositis
  • papule
  • skin vesicle
  • pustule
  • skin ulcer

HPO human phenotypes related to Pyoderma Gangrenosum:

id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pulmonary infiltrates hallmark (90%) HP:0002113
3 myositis hallmark (90%) HP:0100614
4 skin ulcer hallmark (90%) HP:0200042
5 abnormal blistering of the skin typical (50%) HP:0008066

UMLS symptoms related to Pyoderma Gangrenosum:


cachexia, cancer pain, tumor pain, metastatic pain, breakthrough pain

Drugs & Therapeutics for Pyoderma Gangrenosum

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Drugs for Pyoderma Gangrenosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MinocyclinePhase 321610118-90-85281021
Synonyms:
(2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10118-90-8
13614-98-7 (mono-hydrochloride)
4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
4708-96-7
7-Dimethylamino-6-demethyl-6-deoxytetracycline
AC1NQXWM
BRN 3077644
Bio-0062
Borymycin
C07225
C23H27N3O7
CHEBI:50694
CHEBI:529981
CHEMBL1434
CHEMBL259172
CID5281021
CL 59806
CRL-1605 & Minocycline
D05045
HMS2090D03
HSDB 3130
 
LMPK07000002
LS-93850
Lactoferrin B & Minocycline
Lactoferrin H & Minocycline
MINO
MIY
Minociclina
Minociclina [INN-Spanish]
Minociclinum
Minocin
Minocin (Hydrochloride)
Minocline
Minocyclin
Minocycline (USAN/INN)
Minocycline Monohydrochloride
Minocycline [USAN:BAN:INN]
Minocyclinum
Minocyclinum [INN-Latin]
NCGC00178854-01
NSC 141993
NSC141993
UNII-FYY3R43WGO
Vectrin (Hydrochloride)
minociclinum
minocycline
nchembio.559-comp1
2
TacrolimusPhase 21058104987-11-3445643, 439492
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
Anhydrous tacrolimus
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
 
FR900506
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus anhydrous
Tacrolimus hydrate
Tacrolimus, anhydrous
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
3
infliximab364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot StudyActive, not recruitingNCT00203697Phase 3
2An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma GangrenosumTerminatedNCT02326740Phase 3
3An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma GangrenosumTerminatedNCT02315417Phase 3
4A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma GangrenosumTerminatedNCT02318914Phase 3
5Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma GangrenosumCompletedNCT01882504Phase 2
6Canakinumab for Pyoderma GangrenosumCompletedNCT01302795Phase 2
7Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's DiseaseCompletedNCT01233570Phase 2
8RA-18C3 Therapy for Subjects With Pyoderma GangrenosumRecruitingNCT01965613Phase 2
9Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma GangrenosumRecruitingNCT02733094Phase 1, Phase 2
10Safety and Efficacy Study of Humira in Treatment of Pyoderma GangrenosumWithdrawnNCT00730717Phase 2
11Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma GangrenosumWithdrawnNCT00690846Phase 2
12Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel DiseaseCompletedNCT00791557
13Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275
14Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic FactorsRecruitingNCT00933296

Search NIH Clinical Center for Pyoderma Gangrenosum

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: pyoderma gangrenosum

Genetic Tests for Pyoderma Gangrenosum

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Anatomical Context for Pyoderma Gangrenosum

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MalaCards organs/tissues related to Pyoderma Gangrenosum:

34
Skin, Neutrophil, Breast, Bone, Lung, T cells, Myeloid

Animal Models for Pyoderma Gangrenosum or affiliated genes

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MGI Mouse Phenotypes related to Pyoderma Gangrenosum:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6IL1R1, ITGB2, MMP10, MMP9, NOD2, PSTPIP1

Publications for Pyoderma Gangrenosum

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Articles related to Pyoderma Gangrenosum:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. (26934168)
2016
2
Double Jeopardy: Autoimmune Myelofibrosis with Pyoderma Gangrenosum. (27401951)
2016
3
Granulomatous pyoderma gangrenosum of the genitalia in the absence of Crohn's disease. (26392658)
2015
4
Pyoderma gangrenosum secondary to azacitidine in myelodysplastic syndrome. (25765235)
2015
5
Certolizumab pegol - A new therapeutic option for refractory disseminated pyoderma gangrenosum associated with Crohn's disease. (25909366)
2015
6
MEFV gene mutation in two cases of pyoderma gangrenosum with aseptic arthritis. (26537665)
2015
7
The Genetics of Pyoderma Gangrenosum and Implications for Treatment: A Systematic Review. (25350484)
2014
8
Recurrent pyoderma gangrenosum after cesarean delivery successfully treated with vacuum-assisted closure and split thickness skin graft: A case report. (25370183)
2014
9
Pyoderma gangrenosum: a possible cutaneous complication of levamisole-tainted cocaine abuse. (24898775)
2014
10
Pyoderma gangrenosum with renal and splenic impairment - case report. (24346905)
2013
11
Penile pyoderma gangrenosum. (24339469)
2013
12
Dermacase. Can you identify this condition? Pyoderma gangrenosum. (23585606)
2013
13
Pyoderma gangrenosum following foot and ankle surgery: a case report. (23637240)
2013
14
Inpatient Management of Pyoderma Gangrenosum: Treatments, Outcomes, and Clinical Implications. (23903083)
2013
15
Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. (23293022)
2013
16
Pyoderma gangrenosum - a frequently misdiagnosed skin condition. (24033196)
2013
17
Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab. (22301049)
2012
18
Pyoderma gangrenosum in breast reconstruction. (22747349)
2012
19
Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. (22534879)
2012
20
Pyoderma gangrenosum in a patient with primary cutaneous peripheral T-cell lymphoma, not otherwise specified. (23228951)
2012
21
Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with x-linked agammaglobulinaemia. (22439627)
2012
22
A mechanically powered negative pressure device used in conjunction with a bioengineered cell-based product for the treatment of pyoderma gangrenosum: a case report i>?. (22933700)
2012
23
Penile pyoderma gangrenosum successfully treated with topical Imiquimod. (22021975)
2011
24
Staged correction of an equinovarus deformity due to pyoderma gangrenosum using a Taylor spatial frame and tibiotalar calcaneal fusion with an intramedullary device. (21863298)
2011
25
Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum. (22281912)
2011
26
Pyoderma gangrenosum of the breast after bilateral simple mastectomies for ductal carcinoma in situ. (21944335)
2011
27
Pyoderma gangrenosum associated with renal carcinoma. (21571198)
2011
28
Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. (19846444)
2010
29
Beclometasone inhaler used to treat pyoderma gangrenosum. (20500206)
2010
30
Use of infliximab in a patient with pyoderma gangrenosum and rheumatoid arthritis. (20680379)
2010
31
Pyoderma gangrenosum complicating bilateral total knee arthroplasty. (20806762)
2010
32
Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumab. (20804692)
2010
33
A case of atypical pyoderma gangrenosum. (21886741)
2010
34
Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum: Two birds with one stone. (19437575)
2009
35
Pyoderma gangrenosum of the scalp following hair highlights in a postpartum patient. (18086612)
2008
36
An open-label pilot study of alefacept for the treatment of pyoderma gangrenosum. (18384543)
2008
37
A novel therapy for the treatment of pyoderma gangrenosum. (18935734)
2008
38
Pyoderma gangrenosum after totally implanted central venous access device insertion. (18325095)
2008
39
Pyoderma gangrenosum in the head and neck. (17224531)
2007
40
Negative pressure dressing in the management of pyoderma gangrenosum ulcer. (17938337)
2007
41
Cavitary pyoderma gangrenosum treated with local infusion of corticosteroid. (17147967)
2007
42
The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum. (16415387)
2006
43
Bilateral pyoderma gangrenosum complicating minimal access cranial suspension face lift. (19338926)
2006
44
Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis. (16428159)
2005
45
Pyoderma gangrenosum complicated by ecthyma gangrenosum. (15149521)
2004
46
Treatment of pyoderma gangrenosum with etanercept. (15303791)
2004
47
A case of SAPHO syndrome with pyoderma gangrenosum and inflammatory bowel disease masquerading as BehAset's disease. (12918720)
2003
48
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. (9212761)
1997
49
Fatal pyoderma gangrenosum in association with C7 deficiency. (1517503)
1992
50
Pyoderma gangrenosum followed by subcorneal pustular dermatosis in a patient with IgA paraproteinemia. (1999540)
1991

Variations for Pyoderma Gangrenosum

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Expression for genes affiliated with Pyoderma Gangrenosum

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Search GEO for disease gene expression data for Pyoderma Gangrenosum.

Pathways for genes affiliated with Pyoderma Gangrenosum

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Pathways related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.8CXCL8, TNF
29.8CXCL8, TNF
39.7NOD2, TNF
49.6CXCL8, MMP9
59.4CXCL8, ITGB2, TNF
69.4CXCL8, ITGB2, TNF
79.4CXCL8, ITGB2, TNF
89.4CXCL8, ITGB2, TNF
99.3ITGB2, MMP9, TNF
109.3CXCL8, IL1R1, TNF
11
Show member pathways
9.3CXCL8, IL1R1, TNF
12
Show member pathways
9.3CXCL8, IL1R1, TNF
139.2MMP9, NOD2, TNF
14
Show member pathways
9.2MMP10, MMP9, TNF
15
Show member pathways
9.2CXCL8, IFNA2, TNF
169.2CXCL8, IFNA2, TNF
179.1CXCL8, MMP10, MMP9
18
Show member pathways
9.1CXCL8, NOD2, PSTPIP1, TNF
198.9CXCL8, IL1R1, ITGB2, TNF
208.8IFNA2, ITGB2, NOD2, TNF
21
Show member pathways
8.8IFNA2, ITGB2, NOD2, TNF
228.7CXCL8, IL1R1, MMP9, TNF
23
Show member pathways
8.6CXCL8, IFNA2, MMP9, TNF
24
Show member pathways
8.2CXCL8, IFNA2, IL1R1, NOD2, TNF
25
Show member pathways
7.1C7, IFNA2, IL1R1, ITGB2, NOD2, PSTPIP1

GO Terms for genes affiliated with Pyoderma Gangrenosum

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Cellular components related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.8IL1R1, ITGB2, NOD2, TNF
2extracellular spaceGO:00056157.7CXCL8, IFNA2, IL1R1, MMP10, MMP9, TNF
3extracellular regionGO:00055767.1C7, CXCL8, IFNA2, MMP10, MMP9, TNF

Biological processes related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular extravasationGO:004512310.4ITGB2, TNF
2embryonic digestive tract developmentGO:004856610.2CXCL8, TNF
3positive regulation of NIK/NF-kappaB signalingGO:190122410.2NOD2, TNF
4endodermal cell differentiationGO:003598710.1ITGB2, MMP9
5positive regulation of interleukin-8 productionGO:00327579.9NOD2, TNF
6receptor internalizationGO:00316239.7CXCL8, ITGB2
7positive regulation of NF-kappaB transcription factor activityGO:00510929.6ITGB2, NOD2, TNF
8leukocyte migrationGO:00509009.3ITGB2, MMP9, TNF
9extracellular matrix organizationGO:00301989.0ITGB2, MMP9, TNF
10inflammatory responseGO:00069548.6CXCL8, IFNA2, ITGB2, PSTPIP1, TNF

Sources for Pyoderma Gangrenosum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet