Pyogenic Granuloma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NIH Rare Diseases:⁴⁸ Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards based summary: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to clear cell acanthoma and hemangioma. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways are Angiogenesis (CST) and Wnt Signaling Pathway Netpath. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:⁷¹ Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

Sources:
²⁰GeneAnalytics, ²¹GeneCards
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Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)

id	Related Disease	Score	Top Affiliating Genes
1	clear cell acanthoma	10.9
2	hemangioma	10.3
3	capillary hemangioma	10.3
4	sarcoma	10.2
5	mucoepidermoid esophageal carcinoma	10.1	ANGPT1, TEK
6	madras motor neuron disease	10.1	ANGPT1, ANGPT2
7	achromatopsia	10.1	ANGPT1, ANGPT2
8	degenerative disc disease	10.1	TEK, VEGFA
9	hyperinsulinism	10.1	ANGPT2, VEGFA
10	submucous uterine fibroid	10.1	ANGPT2, VEGFA
11	vesiculobullous skin disease	10.1	TEK, VEGFA
12	hypersensitivity syndrome, carbamazepine-induced	10.1	ANGPT2, VEGFA
13	retinal degeneration	10.1	TEK, VEGFA
14	bipolar i disorder	10.1	ANGPT2, VEGFA
15	burns	10.1
16	adult infiltrating astrocytic neoplasm	10.1	ANGPT2, VEGFA
17	subdural empyema	10.0	TEK, VEGFA
18	melanoma	10.0
19	oppositional defiant disorder	10.0	TEK, VEGFA
20	pharc syndrome	10.0	MTOR, VEGFA
21	fibroma	10.0
22	esophagitis	10.0
23	human granulocytic anaplasmosis	10.0	TEK, VEGFA
24	pulmonary blastoma	10.0	ANGPT1, ANGPT2, TEK
25	multinodular goiter	10.0	MTOR, VEGFA
26	paronychia	10.0
27	ossifying fibroma	10.0
28	gingivitis	10.0
29	hyperpituitarism	9.9	ACTC1, TEK
30	isolated anterior cervical hypertrichosis	9.9	ACTC1, VEGFA
31	epidermolysis bullosa simplex, sutosomal recessive 2	9.9	ANGPT2, VEGFA
32	human venous malformation	9.9	ANGPT2, VEGFA
33	gangliosidosis gm1	9.9	ACTC1, MTOR
34	pituitary infarct	9.9	ANGPT2, TEK, VEGFA
35	vulvitis	9.9	ANGPT2, TEK, VEGFA
36	citrullinemia, type ii, neonatal-onset	9.9	ANGPT2, TEK, VEGFA
37	coronary stenosis	9.9	ACTC1, VEGFA
38	common variable immunodeficiency	9.9	ANGPT1, TEK, VEGFA
39	hepatocellular carcinoma	9.9
40	endotheliitis	9.9
41	benign familial neonatal epilepsy	9.9	ACTC1, VEGFA
42	localized junctional epidermolysis bullosa, non-herlitz type	9.9	ANGPT1, ANGPT2, VEGFA
43	mucinous ovarian cystadenoma	9.9	ANGPT1, TEK, VEGFA
44	glycerol kinase deficiency, adult form	9.9	ACTC1, VEGFA
45	mental retardation, autosomal recessive 27	9.9	ANGPT1, ANGPT2, VEGFA
46	sarcomatoid renal cell carcinoma	9.9	MTOR, VEGFA
47	kaposi sarcoma	9.8
48	acne	9.8
49	lymphoma	9.8
50	bacillary angiomatosis	9.8

Graphical network of the top 20 diseases related to Pyogenic Granuloma:

Symptoms & Phenotypes for Pyogenic Granuloma

Sources:
⁴¹MGI
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MGI Mouse Phenotypes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	7.9	ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA
2	homeostasis/metabolism	MP:0005376	7.9	ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA
3	mortality/aging	MP:0010768	7.8	ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA
4	muscle	MP:0005369	7.6	ACTC1, ANGPT1, MTOR, TEK, VEGFA

Drugs & Therapeutics for Pyogenic Granuloma

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Propranolol

approved, investigational

228

525-66-6

4946

Synonyms:

(+-)-Propranolol

(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol

(R)-(+)-propranolol

(S)-(-)-PROPRANOLOL

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol

1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane

1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol

1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol

1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol

1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol

1-Isopropylamino-3-(1-naphthyloxy)-2-propanol

1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol

1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

13013-17-7

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)

3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol

4199-09-1

4199-10-4

525-66-6

AB00053537

AC1L1JA4

AC1Q1QBV

AC1Q1QC0

AKOS000588816

AY 64043

AY-20694

Anaprilin

Anapriline

Angilol

Apsolol

Avlocardyl

BPBio1_001040

BRD-A10070317-003-06-9

BSPBio_000944

BSPBio_002682

Bedranol

Beprane

Berkolol

Beta Neg

Beta-Neg

Beta-Propranolol

Beta-Tablinen

Beta-Timelets

Betachron

Betadren

Betalong

Bio-0732

Bio1_000367

Bio1_000856

Bio1_001345

C07407

C16H21NO2

CBDivE_006180

CCRIS 3082

CHEBI:8499

CHEMBL27

CID4946

Cardinol

Caridolol

Corpendol

D,L-Propranolol

D08443

DB00571

DL-Propranolol hydrochloride

Deralin

DivK1c_000023

Dl-Propranolol Hydrochloride

Dociton

Duranol

EINECS 208-378-0

EINECS 235-867-6

Efektolol

Elbrol

Etalong

Euprovasin

Frekven

HMS2090L21

Herzbase

ICI 45520

IDI1_000023

INDERIDE-40/25

INDERIDE-80/25

Ikopal

Inderal

Inderal La

Inderal hydrochloride

Inderalici

Inderex

Inderide

Inderol

Indobloc

InnoPranXL

Innopran XL

Intermigran

KBio1_000023

KBio2_002515

KBio2_005083

KBio2_007651

KBio3_001766

KBio3_001902

KBio3_002993

KBioGR_001347

KBioGR_001684

KBioGR_002515

KBioSS_002523

Kemi

Kemi S

L000679

LS-122410

LS-184129

Lopac0_000896

Migrastat

MolPort-001-794-623

NCGC00015798-07

NCGC00024690-02

NCGC00024690-03

NINDS_000023

NSC91523

Naprilin

Obsidan

Obzidan

Oposim

Oprea1_304193

PDSP1_000767

PDSP1_001607

PDSP1_001608

PDSP2_000755

PDSP2_001591

PDSP2_001592

Prano-Puren

Pranolol

Prestwick0_000952

Prestwick1_000952

Prestwick2_000952

Prestwick3_000952

Pronovan

Propanalol

Propanix

Propanolol

Propanolol [INN-Spanish]

Prophylux

Propranalol

Propranolol

Propranolol (INN)

Propranolol (TN)

Propranolol Hcl

Propranolol Hcl Intensol

Propranolol Hydrochloride

Propranolol [INN:BAN]

Propranololo

Propranololo [DCIT]

Propranololum

Propranololum [INN-Latin]

Propranur

Proprasylyt

Pylapron

R,S-Propranolol Hydrochloride

Racemic propranolol

Rapynogen

Reducor

Reducor Line

Reducor line

SPBio_001361

SPBio_001658

SPBio_003093

STK735510

Sagittol

Sawatal

Servanolol

Sloprolol

Spectrum2_001301

Spectrum2_001699

Spectrum3_000883

Spectrum3_001071

Spectrum4_000974

Spectrum4_001222

Spectrum5_000751

Sumial

Tesnol

UNII-9Y8NXQ24VQ

b-Propranolol

beta-Propranolol

cMAP_000071

etalong

propranolol

propranololo

β-Propranolol

2

Neurotransmitter Agents

18340

3

Adrenergic beta-Antagonists

1193

4

Adrenergic Antagonists

1573

5

Adrenergic Agents

5352

Interventional clinical trials:

id	Name	Status	NCT ID
1	Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors	Completed	NCT02334930
2	Modified Instrumentation for Surgery to Correct Trichiasis	Completed	NCT00886015
3	Maximizing Trichiasis Surgery Success	Recruiting	NCT03100747
4	Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails	Not yet recruiting	NCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Pyogenic Granuloma:

³⁶

Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Testes

Publications for Pyogenic Granuloma

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Pyogenic Granuloma:

(show top 50) (show all 581)

id	Title	Authors	Year
1	Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis. (27982195)	Lima C.F.... Carvalho Y.R.	2016
2	Capillary hemangioma or pyogenic granuloma. (27041829)	Trivedi S.	2016
3	The Histopathological Spectrum of Pyogenic Granuloma: A Case Series. (27382492)	Marla V.... Shrestha S.	2016
4	Angioleiomyoma of Gingiva Masquerading as Pyogenic Granuloma. (27504561)	Bajpai M.... Kumar M.	2016
5	Timolol for the treatment of pyogenic granuloma (PG) in children. (27543231)	KnAPpfel N.... MartA-n-Santiago A.	2016
6	Pyogenic granuloma underlying cutaneous horn in a young boy. (27057494)	Nair P.A.... Pilani A.P.	2016
7	Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report. (26889266)	Liu J.... Luo D.	2016
8	Periungual Pyogenic Granuloma: The Importance of the Medical History. (27386461)	Alessandrini A.... Piraccini B.M.	2016
9	Oral Pathology Quiz #90. Case Number 4. Pyogenic granuloma. (27159943)		2016
10	Pyogenic granuloma of the duodenum. (26948163)	Meeks M.W.... Lai J.P.	2016
11	Recurrent Pyogenic Granuloma Around Dental Implants: A Rare Case Report. (27333016)	Gefrerer L.... Wojtowicz A.	2016
12	Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser. (27874157)	Al-Mohaya M.A.... Al-Malik A.M.	2016
13	BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. (26802240)	Groesser L.... Hafner C.	2016
14	Oral pyogenic granuloma gravidarum: A case report describing a large bleeding lingual lesion. (28019137)	Guastella C.... Pignataro L.	2016
15	Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision. (27258719)	Daif E.T.	2016
16	Color-Doppler US features of a pyogenic granuloma of the upper dorsum tongue. (26941877)	Cantisani V.... D'Ambrosio F.	2016
17	Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia. (27403353)	Meeks M.W.... Lai J.P.	2016
18	Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. (27210602)	Li J.... Shinder R.	2016
19	Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature. (27192522)	Dastgheib L.... Aslani F.S.	2016
20	Pyogenic granuloma of the jejunum; diagnosis and treatment with double-balloon enteroscopy: A case report. (27161794)	De MarA-a J.... MatanA^ R.	2016
21	Is timolol an effective treatment for pyogenic granuloma? (26872444)	Gupta D.... Thappa D.M.	2016
22	Treatment of pediatric pyogenic granuloma in a functionally and cosmetically sensitive area with the 1064nm ND:Yag laser. (27617472)	Au S.... Scribner J.	2016
23	Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. (27990392)	Bains A.... Tegta G.R.	2016
24	Management of a Recurrent Pyogenic Granuloma of the Hard Palate with Diode Laser: A Case Report. (27330700)	Hasanoglu Erbasar G.N.... Cetiner S.	2016
25	Oral Pyogenic Granuloma After Bone Marrow Transplant in the Pediatric/Adolescent Population: Report of 5 Cases. (27271813)	Cheney-Peters D.... Lund T.C.	2016
26	Agminated eruptive pyogenic granuloma on chin following redundant needle injections. (26813235)	Chae J.B.... Shin J.W.	2016
27	Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. (27116335)	Henning B.... Goldinger S.M.	2016
28	Pyogenic Granuloma in a Patient on Gefitinib. (27865223)	Massa A.... Varela P.	2016
29	Demographics and etiologic factors of nasal pyogenic granuloma. (27122134)	Lopez A.... Scognamiglio T.	2016
30	CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature. (27420917)	Truschnegg A.... Jakse N.	2016
31	Pyogenic Granuloma on the Upper Lip: A Rare Location. (27997445)	Mulinari-Santos G.... Taveira L.A.	2016
32	Pyogenic Granuloma-Like Kaposi's Sarcoma. (27072065)	McClain C.M.... Hafeez Diwan A.	2016
33	Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. (26955141)	Rao A.G.... Anoosha .	2016
34	Extra-Gingival Pyogenic Granuloma Displacing Teeth. (27755424)	Dal PrA! K.J.... Tjioe K.C.	2016
35	Pyogenic granuloma association with isotretinoin treatment for acne. (27885661)	Simmons B.J.... Hu S.	2016
36	Squamous cell carcinoma of the nail fold masquerading as pyogenic granuloma. (27241502)	Khullar G.... Kanwar A.J.	2016
37	Expression of embryonic stem cell markers in pyogenic granuloma. (27509392)	Blackwell M.G.... Tan S.T.	2016
38	Pyogenic granuloma possibly associated with capecitabine therapy. (27864844)	Fujiwara C.... Ishikawa O.	2016
39	A Rare Case of Pyogenic Granuloma with a Natal Tooth. (27891487)	Agarwal N.... Anand A.	2016
40	Pyogenic granuloma-like basal cell carcinoma on the abdomen: A deceptive presentation. (27730056)	Kumar P.... Savant S.S.	2016
41	Chronic red eye due to amelanotic conjuctival melanoma masquerading as pyogenic granuloma. More than meets the eye. (25619360)	Kopsachilis N.... Tsatsos M.	2015
42	Multiple Pyogenic Granulomas After Burns: Response to Conservative Treatment in Five Children. (25895011)	Zhao H.... Fu X.	2015
43	Unusual case of pyogenic granuloma-like Kaposi's sarcoma on the sole. (25683322)	Lee M.K.... Kim K.J.	2015
44	Congenital and Disseminated Pyogenic Granuloma-like Vascular Lesions. (25720992)	Mallet S.... AndrAc N.	2015
45	Oral and Maxillofacial Pathology. Case of the Month. Diagnosis. Pregnancy tumor (Pyogenic granuloma). (26863731)	Khavandgar Z.... Ding M.	2015
46	The Combined use of Diode LASER & Conscious Sedation in the Excision of Pyogenic Granuloma in A Nine-Year-Old Patient. (26816994)	Gokhale S.T.... Bhattacharya D.	2015
47	An intraoral epitheloid hemangioendothelioma masquerading clinically as pyogenic granuloma. (25821301)	Sreenivasan B.S.... Sebastian J.	2015
48	Pyogenic granuloma in differential iron deficiency diagnosis. (25698283)	Bengi G.... YAPrA1koA9lu K.	2015
49	Pyogenic granuloma in the small intestine: a rare cause of obscure gastrointestinal bleeding. (25857476)	Katsurahara M.... Horiki N.	2015
50	Red, exophytic nodule of the plantar foot an unusual presentation of a pyogenic granuloma. (25815662)	Kober M.M.... Khachemoune A.	2015

Genes related to Pyogenic Granuloma

Sources:
²¹GeneCards, ⁵⁰Novoseek
See all MalaCards sources

Genes related to Pyogenic Granuloma:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	TEK	TEK Receptor Tyrosine Kinase	33.48	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	10929871
2	ACTC1	Actin, Alpha, Cardiac Muscle 1	33.12	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	12147659
3	ANGPT2	Angiopoietin 2	31.86	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	10929871, 15089929
4	ANGPT1	Angiopoietin 1	31.74	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	10929871
5	VEGFA	Vascular Endothelial Growth Factor A	28.01	GeneCards inferred via : Disorders, Publications (show sections)
6	MTOR	Mechanistic Target Of Rapamycin	27.77	GeneCards inferred via : Disorders, Publications (show sections)

Variations for Pyogenic Granuloma

Expression for genes affiliated with Pyogenic Granuloma

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 16)

id	Super pathways	Score	Top Affiliating Genes
1	Angiogenesis (CST)³ Show member pathways Angiogenesis³	9.5	ANGPT2, TEK
2	Wnt Signaling Pathway Netpath⁴²	9.5	MTOR, TEK
3	G-protein signaling_H-RAS regulation pathway⁶⁵	9.4	ANGPT1, TEK
4	Immune response IL-23 signaling pathway⁶⁵ Show member pathways Development Angiopoietin - Tie2 signaling⁶⁵ Rac1/Pak1/p38/MMP-2 pathway⁴² IL23-mediated signaling events⁴² Development PDGF signaling via STATs and NF-kB⁶⁵ Angiopoietin receptor Tie2-mediated signaling⁴² Immune response IL-10 signaling pathway⁶⁵ Angiopoietin-TIE2 Signaling⁵⁸	8.9	ANGPT1, ANGPT2, TEK
5	Cell surface interactions at the vascular wall⁶⁰ Show member pathways Tie2 Signaling⁶⁰ PECAM1 interactions⁶⁰ Fibronectin matrix formation⁶⁰	8.9	ANGPT1, ANGPT2, TEK
6	Rheumatoid arthritis³⁴	8.6	ANGPT1, TEK, VEGFA
7	Angiogenesis (WikiPathways)⁴² Show member pathways Angiogenesis⁴²	8.6	ANGPT1, TEK, VEGFA
8	Photodynamic therapy-induced HIF-1 survival signaling⁴²	8.5	ANGPT1, ANGPT2, VEGFA
9	Akt Signaling⁵⁸ Show member pathways p38 Signaling⁵⁸ Tec Kinases Signaling⁵⁸	8.4	ANGPT1, ANGPT2, MTOR, TEK
10	Ras signaling pathway³⁴ Show member pathways Rap1 signaling pathway³⁴	8.1	ANGPT1, ANGPT2, TEK, VEGFA
11	Response to elevated platelet cytosolic Ca2+⁶⁰ Show member pathways Hemostasis⁶⁰ Platelet activation, signaling and aggregation⁶⁰ Platelet degranulation⁶⁰ Disinhibition of SNARE formation⁶⁰	8.1	ANGPT1, ANGPT2, TEK, VEGFA
12	ERK Signaling⁵⁸ Show member pathways ILK Signaling⁵⁸ Molecular Mechanisms of Cancer⁵⁸ MAPK Signaling⁵⁸ Rho Family GTPases⁵⁸	7.6	ANGPT1, ANGPT2, MTOR, TEK, VEGFA
13	TGF-Beta Pathway⁵⁸ Show member pathways JNK Pathway⁵⁸ JAK-STAT Pathway⁵⁸ Regulation of eIF4 and p70S6K⁵⁸ SOCS Pathway⁵⁸ MAPK Family Pathway⁵⁸	7.6	ANGPT1, ANGPT2, MTOR, TEK, VEGFA
14	PI3K-Akt signaling pathway³⁴	7.6	ANGPT1, ANGPT2, MTOR, TEK, VEGFA
15	HIF-1 signaling pathway³⁴	7.6	ANGPT1, ANGPT2, MTOR, TEK, VEGFA
16	PEDF Induced Signaling⁵⁸ Show member pathways Glucocorticoid Receptor Signaling⁵⁸ Endothelin-1 Signaling Pathway⁵⁸ Cytokine-cytokine receptor interaction³⁴ IL-6 Pathway⁵⁸ STAT3 Pathway⁵⁸ PGC1Alpha Pathway⁵⁸ all-trans-Retinoic Acid Signaling in Brain⁵⁸ MIF Regulation of Innate Immune Cells⁵⁸ NFAT Signaling and Lymphocyte Interactions⁵⁸ RAR-Gamma-RXR-Alpha Degradation⁵⁸ MIF Mediated Glucocorticoid Regulation⁵⁸	7.6	ANGPT1, ANGPT2, MTOR, TEK, VEGFA

GO Terms for genes affiliated with Pyogenic Granuloma

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	actin filament	GO:0005884	10.3	ACTC1, TEK
2	microvillus	GO:0005902	9.4	ANGPT1, TEK
3	extracellular space	GO:0005615	8.5	ACTC1, ANGPT1, ANGPT2, VEGFA

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of angiogenesis	GO:0016525	10.3	ANGPT2, TEK
2	cardiac muscle contraction	GO:0060048	10.2	ACTC1, MTOR
3	germ cell development	GO:0007281	10.2	ANGPT2, MTOR
4	maternal process involved in female pregnancy	GO:0060135	10.2	ANGPT2, MTOR
5	negative regulation of endothelial cell apoptotic process	GO:2000352	10.2	ANGPT1, TEK
6	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	10.1	ANGPT1, TEK
7	negative regulation of protein phosphorylation	GO:0001933	10.1	ANGPT1, MTOR
8	positive regulation of focal adhesion assembly	GO:0051894	9.9	TEK, VEGFA
9	growth	GO:0040007	9.9	MTOR, VEGFA
10	heart morphogenesis	GO:0003007	9.9	MTOR, VEGFA
11	positive chemotaxis	GO:0050918	9.8	ANGPT1, VEGFA
12	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.7	ANGPT1, VEGFA
13	positive regulation of cell adhesion	GO:0045785	9.7	ANGPT1, VEGFA
14	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.7	ANGPT1, VEGFA
15	glomerulus vasculature development	GO:0072012	9.7	ANGPT1, ANGPT2, TEK
16	leukocyte migration	GO:0050900	9.7	ANGPT1, ANGPT2, TEK
17	positive regulation of receptor internalization	GO:0002092	9.6	ANGPT1, VEGFA
18	positive regulation of protein kinase B signaling	GO:0051897	9.6	ANGPT1, MTOR, TEK
19	sprouting angiogenesis	GO:0002040	9.4	ANGPT1, TEK
20	positive regulation of angiogenesis	GO:0045766	9.4	ANGPT2, TEK, VEGFA
21	positive regulation of endothelial cell proliferation	GO:0001938	9.4	MTOR, TEK, VEGFA
22	positive regulation of gene expression	GO:0010628	9.4	ACTC1, MTOR, VEGFA
23	positive regulation of endothelial cell migration	GO:0010595	9.3	ANGPT1, TEK, VEGFA
24	positive regulation of protein phosphorylation	GO:0001934	9.3	MTOR, TEK, VEGFA
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.2	ANGPT1, MTOR, VEGFA
26	response to hypoxia	GO:0001666	9.1	ANGPT2, TEK, VEGFA
27	Tie signaling pathway	GO:0048014	8.9	ANGPT1, ANGPT2, TEK
28	negative regulation of apoptotic process	GO:0043066	8.9	ACTC1, ANGPT1, TEK, VEGFA
29	angiogenesis	GO:0001525	8.9	ANGPT1, ANGPT2, TEK, VEGFA