Pyogenic Granuloma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pyogenic Granuloma

Sources:
⁴²NIH Rare Diseases, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to hemangioma and capillary hemangioma. An important gene associated with Pyogenic Granuloma is ANGPT2 (angiopoietin 2), and among its related pathways are Cell adhesion Plasmin signaling and Glioma. The compounds fumagillin and heparin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Wikipedia:⁶³ Pyogenic granuloma (also known as a \"Eruptive hemangioma\", \"Granulation tissue-type hemangioma\",... more...

Aliases & Classifications for Pyogenic Granuloma

Sources:
⁴²NIH Rare Diseases, ⁶⁰UMLS, ⁴⁴Novoseek, ²⁵ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases

ICD10: ²⁵

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Other disorders of skin and subcutaneous tissue, not elsewhere classified

Pyogenic granuloma

Aliases & Descriptions:

pyogenic granuloma ⁴² ⁶⁰

lobular capillary hemangioma ⁴²

granuloma pyogenic ⁴⁴

External Ids:

ICD10²⁵ L98.0

Related Diseases for Pyogenic Granuloma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 191)

id	Related Disease	Score	Top Affiliating Genes
1	hemangioma	31.0	PECAM1, TEK, ACTC1, SLC2A1, THBS1, FGF2
2	capillary hemangioma	31.0	SLC2A1
3	sarcoma	30.8	TP63, PECAM1, TEK, ACTC1, ANGPT2, MTOR
4	kaposi's sarcoma	30.6	PECAM1, TEK, FGF2, VEGFA
5	gingivitis	30.5	DSPP
6	hepatocellular carcinoma	30.4	TP73, TEK, SLC2A1, PLG, FGF2, EPHB4
7	melanoma	30.4	TP73, TP63, PECAM1, TEK, ACTC1, THBS1
8	papilloma	30.3	TP73, TP63, ACTC1
9	angiosarcoma	30.3	PECAM1, TEK, ACTC1, VWF, ANGPT2, ANGPT1
10	breast cancer	30.2	TP73, TP63, PECAM1, TEK, SLC2A1, THBS1
11	conjunctivitis	30.0	PLG
12	neurofibroma	30.0	TP73, ACTC1
13	arteriovenous malformation	30.0	PECAM1, SLC2A1
14	arthritis	30.0	PECAM1, TEK, THBS1, PLG, FGF2, ANGPT1
15	adenoma	30.0	TP73, TP63, ACTC1, SLC2A1, THBS1, ANGPT2
16	myeloma	30.0	FGF2, ANGPT2, VEGFA, MTOR, STAT3
17	rheumatoid arthritis	30.0	PECAM1, TEK, PLG, ANGPT2, ANGPT1, DSPP
18	leukemia	30.0	TP73, PECAM1, TEK, PLG, FGF2, ANGPT2
19	squamous cell carcinoma	30.0	TP73, TP63, PECAM1, TEK, ACTC1, SLC2A1
20	burns	10.4
21	orbital granuloma	10.4
22	esophagitis	10.4
23	paronychia	10.4
24	ossifying fibroma	10.4
25	acquired hemangioma	10.2
26	hemangioma of liver	10.2
27	nasal cavity inverting papilloma	10.2
28	central nervous system hemangioma	10.2
29	inverted papilloma	10.2
30	amelanotic melanoma	10.2
31	barrett's esophagus	10.2
32	acne	10.2
33	basal cell carcinoma	10.2
34	epulis	10.2
35	laryngitis	10.2
36	periodontitis	10.2
37	graft versus host disease	10.0
38	hemangioma of subcutaneous tissue	10.0
39	pleomorphic adenoma	10.0
40	mast-cell sarcoma	10.0
41	congenital epulis	10.0
42	clear cell acanthoma	10.0
43	rosacea	10.0
44	epidermolytic hyperkeratosis	10.0
45	cornea squamous cell carcinoma	10.0
46	giant hemangioma	10.0
47	pemphigus	10.0
48	intussusception	10.0
49	microphthalmia	10.0
50	chronic canaliculitis	10.0

Graphical network of the top 20 diseases related to Pyogenic Granuloma:

Clinical Features for Pyogenic Granuloma

Drugs & Therapeutics for Pyogenic Granuloma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pyogenic Granuloma

Drug clinical trials:

Search ClinicalTrials for Pyogenic Granuloma

Search NIH Clinical Center for Pyogenic Granuloma

Search CenterWatch for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Pyogenic Granuloma:

³²

Skin

Animal Models for Pyogenic Granuloma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Pyogenic Granuloma:

³⁶ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	STAT3, PLG, TP73
2	muscle phenotype	MP:0005369	9.4	FGF2, ACTC1, THBS1, EPHB4, ANGPT1
3	renal/urinary system phenotype	MP:0005367	9.3	THBS1, PECAM1, EFNB2, ANGPT1, PLG
4	reproductive system phenotype	MP:0005389	9.2	TP73, VEGFA, THBS1, PLG, STAT3
5	integument phenotype	MP:0010771	9.0	ANGPT2, PLG, EFNB2, VEGFA, STAT3
6	vision/eye phenotype	MP:0005391	8.7	ANGPT2, EFNB2, FGF2, PLG, THBS1, ATF2
7	liver/biliary system phenotype	MP:0005370	8.6	VEGFA, PLG, STAT3, ATF2, THBS1, PECAM1
8	nervous system phenotype	MP:0003631	8.5	EFNB2, PLG, ATF2, SLC2A1, STAT3, TP73
9	embryogenesis phenotype	MP:0005380	8.3	EPHB4, TP63, SLC2A1, PGR, ATF2, EFNB2
10	homeostasis/metabolism phenotype	MP:0005376	8.1	ATF2, MTOR, EFNB2, PGR, PECAM1, PLG
11	tumorigenesis	MP:0002006	7.9	THBS1, TP73, STAT3, ATF2, VEGFA, FGF2
12	digestive/alimentary phenotype	MP:0005381	7.8	VWF, THBS1, PECAM1, TP73, TP63, EFNB2
13	skeleton phenotype	MP:0005390	7.5	STAT3, ATF2, MTOR, VEGFA, EFNB2, FGF2
14	respiratory system phenotype	MP:0005388	7.4	PECAM1, STAT3, ATF2, MTOR, THBS1, EFNB2
15	normal phenotype	MP:0002873	7.2	TP63, PGR, ACTC1, EFNB2, VEGFA, MTOR
16	behavior/neurological phenotype	MP:0005386	6.9	EFNB2, FGF2, PGR, SLC2A1, TP73, TP63
17	hematopoietic system phenotype	MP:0005397	6.8	TP73, PGR, FGF2, STAT3, ATF2, MTOR
18	cardiovascular system phenotype	MP:0005385	6.7	TP73, STAT3, ATF2, ANGPT1, ANGPT2, EFNB2
19	immune system phenotype	MP:0005387	6.6	VWF, MTOR, VEGFA, PGR, EFNB2, PLG
20	growth/size phenotype	MP:0005378	6.3	ACTC1, VEGFA, SLC2A1, THBS1, PLG, EPHB4
21	cellular phenotype	MP:0005384	5.9	SLC2A1, EFNB2, VWF, VEGFA, TEK, MTOR
22	mortality/aging	MP:0010768	5.2	VWF, PLG, THBS1, SLC2A1, ACTC1, TEK

Publications for Pyogenic Granuloma

Genes related to Pyogenic Granuloma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Pyogenic Granuloma:

(show all 22)

id	Symbol	Description	Score	Implication
1	ANGPT2	angiopoietin 2	20.46	GeneCards inferred : Publications, Disorders (show sections)
2	ACTC1	actin, alpha, cardiac muscle 1	19.55	GeneCards inferred : Publications, Disorders (show sections)
3	PECAM1	platelet/endothelial cell adhesion molecule 1	18.64	GeneCards inferred : Publications, Disorders (show sections)
4	PLG	plasminogen	17.73	GeneCards inferred : Publications, Disorders (show sections)
5	TEK	TEK tyrosine kinase, endothelial	16.82	GeneCards inferred : Publications, Disorders (show sections)
6	THBS1	thrombospondin 1	15.92	GeneCards inferred : Publications, Disorders (show sections)
7	TP73	tumor protein p73	15.01	GeneCards inferred : Publications, Disorders (show sections)
8	DSPP	dentin sialophosphoprotein	14.10	GeneCards inferred : Publications, Disorders (show sections)
9	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	13.19	GeneCards inferred : Publications, Disorders (show sections)
10	ANGPT1	angiopoietin 1	12.28	GeneCards inferred : Publications, Disorders (show sections)
11	PGR	progesterone receptor	11.37	GeneCards inferred : Publications, Disorders (show sections)
12	FGF2	fibroblast growth factor 2 (basic)	10.46	GeneCards inferred : Publications, Disorders (show sections)
13	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	9.55	GeneCards inferred : Publications, Disorders (show sections)
14	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	8.64	GeneCards inferred : Publications, Disorders (show sections)
15	TP63	tumor protein p63	7.73	GeneCards inferred : Publications, Disorders (show sections)
16	VWF	von Willebrand factor	6.82	GeneCards inferred : Publications, Disorders (show sections)
17	VEGFA	vascular endothelial growth factor A	5.92	GeneCards inferred : Publications, Disorders (show sections)
18	EPHB4	EPH receptor B4	5.01	GeneCards inferred : Publications, Disorders (show sections)
19	EFNB2	ephrin-B2	4.10	GeneCards inferred : Publications, Disorders (show sections)
20	ATF2	activating transcription factor 2	3.19	GeneCards inferred : Publications, Disorders (show sections)
21	ESR1	estrogen receptor 1	2.28	GeneCards inferred : Publications, Disorders (show sections)
22	TP53	tumor protein p53	1.37	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Pyogenic Granuloma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	21	21	21
2	LSBio	-	-	22

Genetic Variations for Pyogenic Granuloma

Expression for genes affiliated with Pyogenic Granuloma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

Sources:
¹²EMD Millipore, ²⁹KEGG, ⁴Cell Signaling Technology, ³⁷NCBI BioSystems Database, ⁵³Reactome, ⁵¹QIAGEN
See all sources

Pathways related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 37)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Cell adhesion Plasmin signaling¹²	10.3	PLG
2	Glioma²⁹ Hide members Prostate cancer²⁹	10.2	MTOR
3	Rheumatoid arthritis²⁹	10.0	TEK, ANGPT1
4	Tyrosine Kinases / Adaptors⁴	10.0	EFNB2
5	Development NOTCH1-mediated pathway for NF-KB activity modulation¹² Hide members Development Notch Signaling Pathway¹²	9.9	TP63, TP73
6	Apoptosis Modulation and Signaling³⁷ Hide members Apoptosis³⁷	9.9	TP63, TP73
7	Tie2 Signaling⁵³	9.8	TEK, ANGPT1, ANGPT2
8	Syndecan-4-mediated signaling events³⁷	9.8	THBS1, FGF2, PLG
9	Cell surface interactions at the vascular wall⁵³	9.7	PECAM1, ANGPT1, ANGPT2, TEK
10	Non-integrin membrane-ECM interactions⁵³ Hide members Integrin cell surface interactions⁵³ ECM-receptor interaction²⁹ Syndecan interactions⁵³	9.6	FGF2, VWF, PECAM1
11	Adipocytokine signaling pathway²⁹	9.6	MTOR, STAT3, SLC2A1
12	EphrinB-EPHB pathway³⁷	9.5	EPHB4, EFNB2
13	PEDF Induced Signaling⁵¹ Hide members STAT3 Pathway⁵¹ Endothelin-1 Signaling Pathway⁵¹ all-trans-Retinoic Acid Signaling in Brain⁵¹ NFAT Signaling and Lymphocyte Interactions⁵¹ RAR-Gamma-RXR-Alpha Degradation⁵¹ PGC1Alpha Pathway⁵¹ Glucocorticoid Receptor Signaling⁵¹ IL-6 Pathway⁵¹ MIF Regulation of Innate Immune Cells⁵¹ MIF Mediated Glucocorticoid Regulation⁵¹	9.4	TEK, ANGPT2, ANGPT1, EPHB4
14	Pathways in cancer²⁹	9.3	FGF2, SLC2A1, STAT3, MTOR
15	Angiogenesis³⁷	9.3	TEK, FGF2, VEGFA, ANGPT1
16	Platelet activation, signaling and aggregation⁵³ Hide members Hemostasis⁵³	9.3	VWF, PLG, THBS1, TEK, PECAM1
17	PIP3 activates AKT signaling⁵³ Hide members Signaling by ERBB4⁵³ PI-3K cascade⁵³ Signaling by SCF-KIT⁵³ PI3K events in ERBB2 signaling⁵³ PI3K events in ERBB4 signaling⁵³ GAB1 signalosome⁵³ PI3K/AKT Signaling in Cancer⁵³ Constitutive PI3K/AKT Signaling in Cancer⁵³ PI3K/AKT activation⁵³	9.3	FGF2, PGR, MTOR, STAT3
18	Immune response IFN gamma signaling pathway Hide members IFN-gamma pathway³⁷ Immune response IFN gamma signaling pathway¹²	9.2	MTOR, STAT3, ATF2
19	Immune response IL-12-induced IFN-gamma production¹² Hide members IL12-mediated signaling events³⁷	9.2	STAT3, ATF2, MTOR
20	CDC42 signaling events³⁷ Hide members RAC1 signaling pathway³⁷	9.2	STAT3, ATF2, MTOR
21	Focal Adhesion³⁷ Hide members Focal adhesion²⁹ HGF Pathway⁵¹	9.2	VWF, STAT3, VEGFA, THBS1
22	Signaling by FGFR⁵³ Hide members Signaling by PDGF⁵³ Signaling by EGFR⁵³ DAP12 signaling⁵³ Signaling by ERBB2⁵³ DAP12 interactions⁵³ Signaling by FGFR in disease⁵³ Downstream signaling of activated FGFR⁵³ Signalling by NGF⁵³ Downstream signal transduction⁵³ Signaling by EGFR in Cancer⁵³ NGF signalling via TRKA from the plasma membrane⁵³	9.2	FGF2, MTOR, PLG, THBS1, STAT3
23	Angiogenesis⁴	9.1	PECAM1, FGF2, ANGPT2, TEK, EFNB2
24	Platelet degranulation ⁵³ Hide members Response to elevated platelet cytosolic Ca2+⁵³	9.1	VWF, THBS1, PECAM1, PLG, VEGFA
25	Development PDGF signaling via STATs and NF-kB Hide members Angiopoietin-TIE2 Signaling⁵¹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development Angiopoietin - Tie2 signaling¹² IL23-mediated signaling events³⁷ Immune response IL-10 signaling pathway¹² Development PDGF signaling via STATs and NF-kB¹² Immune response IL-23 signaling pathway¹²	9.1	STAT3, TEK, PLG, FGF2, ANGPT1, ANGPT2
26	Development HGF signaling pathway¹² Hide members Neurotrophin signaling pathway²⁹ Renal cell carcinoma²⁹ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)³⁷ Signaling of Hepatocyte Growth Factor Receptor³⁷	9.0	TP73, STAT3, MTOR, VEGFA, SLC2A1
27	Integrin Pathway⁵¹ Hide members Transendothelial Migration of Leukocytes⁵¹ Inhibition of Angiogenesis by TSP1⁵¹ UPA-UPAR Pathway⁵¹ GnRH Signaling⁵¹	9.0	PLG, STAT3, THBS1, ATF2, PECAM1
28	Proteoglycans in cancer²⁹	9.0	STAT3, MTOR, THBS1, FGF2, VEGFA
29	MicroRNAs in cancer²⁹	8.9	STAT3, TP63, THBS1, MTOR, VEGFA
30	PAK Pathway⁵¹ Hide members Antioxidant Action of Vitamin-C⁵¹ Epithelial Adherens Junctions⁵¹	8.7	ATF2, ANGPT1, ANGPT2, TEK, FGF2, SLC2A1
31	Translation Insulin regulation of translation Hide members Cell adhesion PLAU signaling¹² Transcription Receptor-mediated HIF regulation¹² mTOR signaling pathway²⁹ Development CNTF receptor signaling¹² Insulin signaling pathway²⁹ ErbB2/ErbB3 signaling events³⁷ Development Growth hormone signaling via PI3K/AKT and MAPK cascades¹² Translation Insulin regulation of translation¹² Translation Regulation activity of EIF4F¹²	8.6	MTOR, PLG, VEGFA, STAT3, ATF2
32	HIF-1 signaling pathway²⁹	8.6	STAT3, MTOR, VEGFA, ANGPT1, SLC2A1, ANGPT2
33	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	8.2	STAT3, TEK, FGF2, EPHB4, ANGPT2, ANGPT1
34	TGF-Beta Pathway⁵¹ Hide members JAK-STAT Pathway⁵¹ JNK Pathway⁵¹ SOCS Pathway⁵¹ Regulation of eIF4 and p70S6K⁵¹ MAPK Family Pathway⁵¹	8.2	STAT3, ATF2, ANGPT1, ANGPT2, EPHB4, FGF2
35	Rho Family GTPases⁵¹ Hide members ILK Signaling⁵¹ Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹ MAPK Signaling⁵¹	8.2	ANGPT1, EPHB4, ANGPT2, FGF2, TEK, STAT3
36	Signaling by GPCR⁵³ Hide members Signal Transduction⁵³	7.9	FGF2, MTOR, STAT3, PGR, VWF, PLG
37	PI3K-Akt signaling pathway²⁹	7.6	ANGPT2, ANGPT1, VEGFA, MTOR, FGF2, VWF

Compounds for genes affiliated with Pyogenic Granuloma

Sources:
⁴⁴Novoseek, ⁵⁹Tocris Bioscience, ¹¹DrugBank, ²⁸IUPHAR, ²⁴HMDB, ⁴⁹PharmGKB, ²BitterDB
See all sources

Compounds related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show top 50) (show all 96)

id	Compound	Score	Top Affiliating Genes
1	fumagillin⁴⁴ ⁵⁹ ¹¹	11.9	VEGFA, PLG, FGF2
2	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.8	VEGFA, PLG, SLC2A1, PECAM1
3	mannitol⁴⁴ ¹¹	10.7	ATF2, SLC2A1, TP73
4	infliximab⁴⁴ ⁴⁹ ¹¹	11.6	ANGPT2, TEK, VEGFA, FGF2
5	hematoxylin⁴⁴	9.6	PLG, ACTC1, PECAM1, TP63
6	cytochalasin d⁴⁴ ⁵⁹	10.5	FGF2, VWF, PECAM1, SLC2A1, THBS1
7	thalidomide⁴⁴ ⁴⁹ ⁵⁹ ¹¹	12.4	VEGFA, FGF2, PLG, THBS1, STAT3
8	steroid⁴⁴	9.4	MTOR, ANGPT2, ACTC1, PLG, ANGPT1
9	fibrinogen⁴⁴	9.4	PECAM1, ANGPT1, ANGPT2, VWF, PLG, THBS1
10	gefitinib⁴⁴ ⁴⁹ ¹¹	11.3	PLG, VEGFA, FGF2, MTOR, STAT3
11	arsenite⁴⁴ ²⁴	10.3	MTOR, STAT3, VEGFA, PGR
12	tetracycline⁴⁴ ¹¹	10.3	DSPP, ANGPT1, VWF, THBS1, TP73, FGF2
13	docetaxel⁴⁴ ⁴⁹ ⁵⁹ ¹¹	12.3	PLG, PGR, VEGFA, MTOR, STAT3
14	serine⁴⁴	9.3	THBS1, FGF2, SLC2A1, TEK, PECAM1, PLG
15	imatinib⁴⁴ ⁴⁹ ¹¹	11.3	VEGFA, ACTC1, MTOR, STAT3, TP73
16	paclitaxel⁴⁴ ⁴⁹ ¹¹	11.3	PGR, VEGFA, STAT3, PLG, ANGPT1, THBS1
17	glucose⁴⁴	9.2	SLC2A1, ACTC1, THBS1, ANGPT2, ANGPT1, ATF2
18	ribonucleic acid⁴⁴	9.2	ANGPT1, PGR, THBS1, SLC2A1, TEK, PECAM1
19	wortmannin⁴⁴	9.2	STAT3, MTOR, ANGPT1, ANGPT2, THBS1, SLC2A1
20	anisomycin⁴⁴ ¹¹	10.2	MTOR, PECAM1, SLC2A1, ATF2, STAT3
21	agar⁴⁴	9.2	SLC2A1, STAT3, FGF2, PECAM1, DSPP, PGR
22	prostacyclin⁴⁴	9.1	VEGFA, ANGPT1, FGF2, VWF, PECAM1, THBS1
23	tamoxifen⁴⁴ ⁴⁹ ²⁸ ¹¹	12.1	THBS1, PGR, STAT3, MTOR, VEGFA, PLG
24	progestin⁴⁴	9.1	ANGPT2, PGR, VEGFA, ANGPT1
25	matrigel⁴⁴	9.1	STAT3, MTOR, ANGPT1, PLG, THBS1, ACTC1
26	actinomycin d⁴⁴	9.0	FGF2, VEGFA, STAT3, SLC2A1, PECAM1, TP73
27	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.0	ANGPT2, FGF2, SLC2A1, DSPP, VEGFA, MTOR
28	rapamycin⁴⁴	8.9	SLC2A1, THBS1, ANGPT1, VEGFA, PECAM1, STAT3
29	5fluorouracil⁴⁴	8.9	STAT3, VEGFA, MTOR, PGR, THBS1, SLC2A1
30	phosphatidylinositol⁴⁴	8.8	STAT3, SLC2A1, ANGPT1, TEK, ANGPT2, FGF2
31	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	13.8	MTOR, VEGFA, FGF2, STAT3, PGR, SLC2A1
32	calcitriol⁴⁴ ⁵⁹ ¹¹ ²⁴	11.8	FGF2, THBS1, DSPP, ATF2, SLC2A1
33	ly294002⁴⁴	8.7	MTOR, STAT3, VEGFA, THBS1, ANGPT1, ANGPT2
34	pd 98,059⁴⁴	8.6	ANGPT1, ATF2, SLC2A1, THBS1, MTOR, FGF2
35	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	11.6	PGR, MTOR, VWF, THBS1, TP63, ACTC1
36	nitric oxide⁴⁴ ¹¹ ²⁴	10.6	VWF, ATF2, ANGPT2, PECAM1, TEK, THBS1
37	threonine⁴⁴	8.4	ATF2, THBS1, PECAM1, TP73, MTOR, TEK
38	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.4	TP73, VEGFA, TP63, SLC2A1, ATF2, STAT3
39	thymidine⁴⁴ ²⁴	9.3	EPHB4, ANGPT2, ANGPT1, PECAM1, FGF2, PLG
40	oxygen⁴⁴ ²⁴	9.3	ANGPT2, THBS1, ATF2, SLC2A1, ACTC1, TEK
41	h2o2⁴⁴	8.3	ATF2, STAT3, THBS1, VWF, DSPP, PECAM1
42	alanine⁴⁴	8.2	DSPP, SLC2A1, STAT3, ATF2, FGF2, THBS1
43	doxorubicin⁴⁴ ⁴⁹ ¹¹	10.0	VEGFA, STAT3, TP63, TP73, THBS1, PGR
44	cysteine⁴⁴	7.9	PLG, PGR, DSPP, VWF, ATF2, STAT3
45	cyclosporin a⁴⁴ ²⁸ ⁵⁹	9.7	STAT3, ATF2, MTOR, ANGPT1, ANGPT2, FGF2
46	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	10.6	VWF, TP63, MTOR, ACTC1, PECAM1, ATF2
47	paraffin⁴⁴	7.0	STAT3, TP73, DSPP, VEGFA, ANGPT1, ANGPT2
48	retinoic acid⁴⁴ ²⁴	7.9	MTOR, EFNB2, PECAM1, ATF2, ANGPT2, FGF2
49	vegf⁴⁴	5.8	STAT3, MTOR, ANGPT1, ANGPT2, EFNB2, EPHB4
50	tyrosine⁴⁴	5.4	TP63, PECAM1, TEK, ACTC1, SLC2A1, TP73

GO Terms for genes affiliated with Pyogenic Granuloma

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Pyogenic Granuloma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule	GO:031091	9.9	THBS1, VWF
2	platelet alpha granule lumen	GO:031093	9.4	VEGFA, VWF, PLG, THBS1
3	cell surface	GO:009986	8.9	VEGFA, EPHB4, PLG, THBS1, TEK
4	extracellular space	GO:005615	8.8	VEGFA, ANGPT1, ANGPT2, FGF2, PLG, THBS1
5	extracellular region	GO:005576	8.1	FGF2, THBS1, PLG, VWF, TEK, VEGFA

Biological processes related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 34)

id	Name	GO ID	Score	Top Affiliating Genes
1	glomerulus vasculature development	GO:072012	10.4	ANGPT2, ANGPT1
2	negative regulation of fibrinolysis	GO:051918	10.2	THBS1, PLG
3	Tie signaling pathway	GO:048014	10.2	ANGPT1, TEK, ANGPT2
4	negative regulation of angiogenesis	GO:016525	10.2	TEK, THBS1, ANGPT2
5	negative regulation of blood vessel endothelial cell migration	GO:043537	10.2	ANGPT2, THBS1, FGF2
6	sprouting angiogenesis	GO:002040	10.2	TEK, THBS1, ANGPT1
7	positive regulation of intracellular protein kinase cascade	GO:010740	10.1	TEK, VEGFA
8	mitotic G1 DNA damage checkpoint	GO:031571	10.1	TP63, TP73
9	negative regulation of cell-substrate adhesion	GO:010812	10.1	ANGPT2, PLG
10	cell-substrate adhesion	GO:031589	10.1	VWF, ANGPT1
11	leukocyte migration	GO:050900	10.0	ANGPT1, ANGPT2, TEK, PECAM1
12	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.9	VEGFA, ANGPT1, TEK
13	negative regulation of endothelial cell apoptotic process	GO:2000352	9.9	TEK, ANGPT1
14	positive regulation of protein phosphorylation	GO:001934	9.9	MTOR, VEGFA
15	positive chemotaxis	GO:050918	9.9	ANGPT1, FGF2, VEGFA
16	positive regulation of protein kinase B signaling cascade	GO:051897	9.9	ANGPT1, TEK, MTOR, THBS1
17	activation of MAPK activity	GO:000187	9.8	THBS1, TP73, FGF2
18	positive regulation of endothelial cell migration	GO:010595	9.8	ANGPT1, THBS1, TEK, VEGFA
19	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	ANGPT1, VEGFA, MTOR
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.7	ANGPT1, TEK, FGF2
21	positive regulation of blood vessel endothelial cell migration	GO:043536	9.7	VEGFA, FGF2, THBS1, ANGPT1
22	positive regulation of endothelial cell proliferation	GO:001938	9.6	FGF2, VEGFA, MTOR, TEK
23	positive regulation of angiogenesis	GO:045766	9.6	ANGPT2, VEGFA, FGF2, THBS1, TEK
24	positive regulation of focal adhesion assembly	GO:051894	9.6	VEGFA, TEK
25	outflow tract morphogenesis	GO:003151	9.6	ATF2, THBS1, VEGFA
26	angiogenesis	GO:001525	9.5	VEGFA, ANGPT2, EPHB4, TEK
27	platelet degranulation	GO:002576	9.5	VWF, VEGFA, PLG, THBS1, PECAM1
28	platelet activation	GO:030168	9.5	THBS1, VEGFA, PLG, VWF, PECAM1
29	negative regulation of apoptotic process	GO:043066	9.3	VEGFA, THBS1, TEK, TP63, ANGPT1
30	cell migration involved in sprouting angiogenesis	GO:002042	9.2	EFNB2, VEGFA, EPHB4, FGF2
31	signal transduction	GO:007165	9.1	STAT3, MTOR, ANGPT2, PGR, FGF2, TEK
32	nervous system development	GO:007399	9.1	STAT3, EFNB2, FGF2, VEGFA
33	cell adhesion	GO:007155	9.0	EFNB2, PECAM1, EPHB4, THBS1, VWF
34	blood coagulation	GO:007596	8.9	TEK, PLG, VEGFA, ANGPT1, ANGPT2, VWF