MCID: PYG006
MIFTS: 49

Pyogenic Granuloma malady

Rare diseases, Skin diseases categories
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Summaries for Pyogenic Granuloma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to hemangioma and sarcoma. An important gene associated with Pyogenic Granuloma is ANGPT2 (angiopoietin 2), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and HIF-1 signaling pathway. The compounds glycosaminoglycan and infliximab have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:65 Pyogenic granuloma (also known as a \"Eruptive hemangioma\", \"Granulation tissue-type hemangioma\",... more...

Aliases & Classifications for Pyogenic Granuloma

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43NIH Rare Diseases, 62UMLS, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

pyogenic granuloma 43 62
lobular capillary hemangioma 43
granuloma pyogenic 45


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ICD1025 L98.0

Related Diseases for Pyogenic Granuloma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to pyogenic granuloma

Symptoms for Pyogenic Granuloma

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Drugs & Therapeutics for Pyogenic Granuloma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pyogenic Granuloma

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

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Anatomical Context for Pyogenic Granuloma

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33MalaCards
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MalaCards organs/tissues related to Pyogenic Granuloma:

33
Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Testes, Trachea, Adrenal gland, T cells, Kidney, Small intestine, Breast

Animal Models for Pyogenic Granuloma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pyogenic Granuloma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8PLG, ANGPT2, PECAM1
2MP:00053818.6PECAM1, ANGPT2, PLG
3MP:00053698.5ACTC1, PECAM1, TEK
4MP:00053848.0TEK, PECAM1, ACTC1, PLG
5MP:00053857.6PLG, ACTC1, ANGPT2, PECAM1, TEK
6MP:00053767.6TEK, PECAM1, ANGPT2, ACTC1, PLG

Publications for Pyogenic Granuloma

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52PubMed
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Articles related to Pyogenic Granuloma:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Pyogenic granuloma of the gingiva: A misnomer? - A case report and review of literature. (24174735)
2013
2
Case of the month. Pyogenic granuloma. (23923461)
2013
3
Esophageal pyogenic granuloma: endosonographic findings and endoscopic treatments. (23423701)
2013
4
Oral capillary haemangioma mimicking pyogenic granuloma: a challenge for diagnosis and management. (23417375)
2013
5
Pyogenic granuloma satellite of deep infection: tuberculous osteitis. (23647787)
2013
6
Dermoscopic and histological correlation of an atypical case of pyogenic granuloma. (23488571)
2013
7
Painless red lesion on the tongue. Pyogenic granuloma. (22414511)
2012
8
Exuberant pyogenic granuloma in extragingival site. (22936151)
2012
9
Photodynamic therapy with 5-aminolevulinic acid intralesional injection for pyogenic granuloma. (22250252)
2012
10
Giant cell tumor of tendon sheath mimicking pyogenic granuloma in the index finger pulp: a case report. (22351549)
2012
11
"Pyogenic granuloma - Hyperplastic lesion of the gingiva: case reports". (23091574)
2012
12
Concurrent occurrence of mucocele and pyogenic granuloma. (22028553)
2011
13
Pregnancy-associated pyogenic granuloma of the lip: a case report. (21970285)
2011
14
Violaceous papules of the back: a quiz. Diagnosis: recurrent pyogenic granuloma or Warner and Wilson-Jones syndrome (1, 2). (21103841)
2011
15
Clinical inquiries. What's the best treatment for pyogenic granuloma? (20074501)
2010
16
Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population. (20417014)
2010
17
Oral pathology quiz. Case number 2. Pyogenic granuloma. (20658767)
2010
18
Multiple pyogenic granuloma of the penis in a four-year-old child: a case report. (19918487)
2009
19
Congenital disseminated pyogenic granuloma. (19706097)
2009
20
Pyogenic granuloma: an unusual cause of massive gastrointestinal bleeding from the small bowel. (19373418)
2009
21
Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)
2009
22
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
23
Extragingival pyogenic granuloma: a case report. (19055747)
2008
24
Successful treatment of a therapy-resistant pyogenic granuloma with topical imiquimod 5% cream. (16766338)
2006
25
Comparison of cryotherapy and curettage for the treatment of pyogenic granuloma: a randomized trial. (16536810)
2006
26
Recurrent intraoral pyogenic granuloma with satellitosis treated with corticosteroids. (16390473)
2006
27
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
28
Is pyogenic granuloma associated with Bartonella infection? (16310070)
2005
29
Treatment of pyogenic granuloma by sodium tetradecyl sulfate sclerotherapy. (15897398)
2005
30
Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. (16005715)
2005
31
Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. (14613084)
2003
32
Pediatric pyogenic granuloma of the glans penis. (12639669)
2003
33
Pyogenic granuloma-like lesions during capecitabine therapy. (12452889)
2002
34
Laryngeal pyogenic granulomas do not express oestrogen or progesterone receptors. (11667991)
2001
35
Onychomadesis and pyogenic granuloma following cast immobilization. (11176706)
2001
36
Pyogenic granuloma: who are you? (11495513)
2001
37
Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. (10929871)
2000
38
Pyogenic granuloma: a complication of transconjunctival incisions. (10744252)
2000
39
Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma. (10233658)
1999
40
Multiple pyogenic granuloma demonstrated by SPECT using 99Tcm-labelled red blood cells. (10474504)
1999
41
Plaque radiation therapy for recurrent conjunctival pyogenic granuloma. (9565059)
1998
42
Pyogenic granuloma of the cornea. (9630306)
1998
43
Oral angiosarcoma misdiagnosed as a pyogenic granuloma. (9580135)
1998
44
The late development of oral pyogenic granuloma as a complication of pregnancy: a case report. (9051984)
1996
45
Oral pyogenic granuloma in pregnancy. (9764875)
1995
46
Intraoral pyogenic granuloma after allogeneic bone marrow transplant. Report of three cases. (7838468)
1994
47
Pyogenic granuloma following treatment of verruca vulgaris with cryotherapy and Duoplant. (2022132)
1991
48
The pyogenic granuloma. (6393917)
1984
49
A pyogenic granuloma and an irritation fibroma--case report. (297013)
1979
50
Pyogenic granuloma of the nasal cavity. (13902293)
1962

Variations for Pyogenic Granuloma

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Expression for genes affiliated with Pyogenic Granuloma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

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50PathCards, 55Reactome, 30KEGG, 5Cell Signaling Technology, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Pyogenic Granuloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3PECAM1, PLG
29.2ANGPT2, TEK
39.2ANGPT2, TEK
4
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.7PLG, ANGPT2, TEK
58.6ANGPT2, PECAM1, TEK
6
Show member pathways
8.6TEK, PECAM1, ANGPT2
7
Show member pathways
8.1PLG, ANGPT2, PECAM1, TEK

Compounds for genes affiliated with Pyogenic Granuloma

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1glycosaminoglycan459.4PECAM1, ACTC1
2infliximab45 51 1111.4ANGPT2, TEK
3formaldehyde45 2410.3ACTC1, PECAM1
4steroid459.2ANGPT2, ACTC1, PLG
5hematoxylin459.1PLG, ACTC1, PECAM1
6fibrinogen459.1PLG, ANGPT2, PECAM1
7cyclosporin a45 29 6111.1PECAM1, ANGPT2, ACTC1
8p002459.1PECAM1, TEK
9estrogen458.9PECAM1, ANGPT2, ACTC1
10retinoic acid45 249.8ACTC1, ANGPT2, PECAM1
11glucose458.6PECAM1, ANGPT2, ACTC1, PLG
12atp45 299.6PLG, ANGPT2, PECAM1
13calcium45 51 24 1111.5PLG, ACTC1, ANGPT2, PECAM1
14ribonucleic acid458.4ACTC1, ANGPT2, PECAM1, TEK
15paraffin458.4TEK, PECAM1, ANGPT2, ACTC1
16thymidine45 249.4TEK, PECAM1, ANGPT2, PLG
17nitric oxide45 24 1110.3PLG, ANGPT2, PECAM1, TEK
18cysteine458.3TEK, PECAM1, ANGPT2, PLG
19serine458.3PLG, ANGPT2, PECAM1, TEK
20matrigel457.9PLG, ACTC1, ANGPT2, PECAM1, TEK
21vegf457.9TEK, PECAM1, ANGPT2, ACTC1, PLG
22oxygen45 248.9TEK, PECAM1, ANGPT2, ACTC1, PLG
23tyrosine457.8TEK, PECAM1, ANGPT2, ACTC1, PLG

GO Terms for genes affiliated with Pyogenic Granuloma

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16Gene Ontology
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Cellular components related to Pyogenic Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1ACTC1, PLG
2actin filamentGO:0058849.0ACTC1, TEK
3extracellular spaceGO:0056158.4PLG, ACTC1, ANGPT2, PECAM1
4plasma membraneGO:0058868.1PLG, ANGPT2, PECAM1, TEK

Biological processes related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-substrate adhesionGO:0108129.7PLG, ANGPT2
2Tie signaling pathwayGO:0480149.5ANGPT2, TEK
3platelet degranulationGO:0025769.4PLG, PECAM1
4organ regenerationGO:0311009.4ANGPT2, TEK
5negative regulation of angiogenesisGO:0165259.3TEK, ANGPT2
6platelet activationGO:0301689.3PLG, PECAM1
7positive regulation of angiogenesisGO:0457669.3ANGPT2, TEK
8response to hypoxiaGO:0016669.1ANGPT2, TEK
9angiogenesisGO:0015258.9ANGPT2, TEK
10leukocyte migrationGO:0509008.8TEK, PECAM1, ANGPT2
11signal transductionGO:0071658.6TEK, PECAM1, ANGPT2
12blood coagulationGO:0075968.3PLG, ANGPT2, PECAM1, TEK

Products for genes affiliated with Pyogenic Granuloma

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Sources for Pyogenic Granuloma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet