MCID: PYG006
MIFTS: 41

Pyogenic Granuloma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

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Aliases & Descriptions for Pyogenic Granuloma:

Name: Pyogenic Granuloma 47 67
Lobular Capillary Hemangioma 47
 
Granuloma Pyogenic 49

Classifications:



External Ids:

ICD1029 L98.0

Summaries for Pyogenic Granuloma

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Wikipedia:70 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

MalaCards based summary: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to rheumatoid arthritis and clear cell acanthoma, and has symptoms including leser-trélat sign An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways are Angiogenesis (CST) and G-protein signaling_H-RAS regulation pathway. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are cardiovascular system and muscle.

Related Diseases for Pyogenic Granuloma

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Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.3ANGPT1, TEK, VEGFA
2clear cell acanthoma10.9
3hemangioma10.3
4capillary hemangioma10.3
5bile duct mucoepidermoid carcinoma10.2ANGPT1, TEK
6sarcoma10.2
7achromatopsia10.1ANGPT1, ANGPT2
8epidermolysis bullosa10.1TEK, VEGFA
9cyclothymic disorder10.1TEK, VEGFA
10hole retinal cyst10.1ANGPT2, VEGFA
11burns10.1
12epidural abscess10.1TEK, VEGFA
13gasserian ganglion meningioma10.0ANGPT2, VEGFA
14fibroma10.0
15esophagitis10.0
16renal fibrosis10.0TEK, VEGFA
17opportunistic mycosis10.0ANGPT2, VEGFA
18paronychia10.0
19ossifying fibroma10.0
20gingivitis10.0
21renal tubular transport disease9.9TEK, VEGFA
22neuropathy, hereditary sensory and autonomic, type vi9.9ANGPT2, VEGFA
23hematopoietic stem cell transplantation9.9TEK, VEGFA
24hepatocellular carcinoma9.9
25endotheliitis9.9
26frontal sinus squamous cell carcinoma9.9ACTC1, TEK
27kaposi sarcoma9.9
28acne9.9
29lymphoma9.9
30bacillary angiomatosis9.9
31basal cell carcinoma9.9
32amelanotic melanoma9.9
33weber syndrome9.9
34angiomatosis9.9
35striatonigral degeneration9.8ANGPT1, ANGPT2, TEK
36holoprosencephaly9.8ANGPT2, VEGFA
37breast cancer9.8
38anaplastic large cell lymphoma9.8
39leukemia9.8
40angiosarcoma9.8
41vaginitis9.8
42laryngitis9.8
43epulis9.8
44periodontitis9.8
45gigantism9.8
46hemangioendothelioma9.8
47iridogoniodysgenesis and skeletal anomalies9.8ACTC1, VEGFA
48vertebral artery occlusion9.7ANGPT2, TEK, VEGFA
49apocrine adenoma9.7ANGPT2, TEK, VEGFA
50citrullinemia, adult-onset type ii9.7ANGPT2, TEK, VEGFA

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to pyogenic granuloma

Symptoms for Pyogenic Granuloma

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UMLS symptoms related to Pyogenic Granuloma:


leser-trélat sign

Drugs & Therapeutics for Pyogenic Granuloma

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Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Propranololapproved, investigational216525-66-64946
Synonyms:
(+-)-Propranolol
(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol
(R)-(+)-propranolol
(S)-(-)-PROPRANOLOL
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane
1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
13013-17-7
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
4199-09-1
4199-10-4
525-66-6
AB00053537
AC1L1JA4
AC1Q1QBV
AC1Q1QC0
AKOS000588816
AY 64043
AY-20694
Anaprilin
Anapriline
Angilol
Apsolol
Avlocardyl
BPBio1_001040
BRD-A10070317-003-06-9
BSPBio_000944
BSPBio_002682
Bedranol
Beprane
Berkolol
Beta Neg
Beta-Neg
Beta-Propranolol
Beta-Tablinen
Beta-Timelets
Betachron
Betadren
Betalong
Bio-0732
Bio1_000367
Bio1_000856
Bio1_001345
C07407
C16H21NO2
CBDivE_006180
CCRIS 3082
CHEBI:8499
CHEMBL27
CID4946
Cardinol
Caridolol
Corpendol
D,L-Propranolol
D08443
DB00571
DL-Propranolol hydrochloride
Deralin
DivK1c_000023
Dl-Propranolol Hydrochloride
Dociton
Duranol
EINECS 208-378-0
EINECS 235-867-6
Efektolol
Elbrol
Etalong
Euprovasin
Frekven
HMS2090L21
Herzbase
ICI 45520
IDI1_000023
INDERIDE-40/25
INDERIDE-80/25
Ikopal
Inderal
Inderal La
Inderal hydrochloride
Inderalici
Inderex
Inderide
Inderol
Indobloc
InnoPranXL
 
Innopran XL
Intermigran
KBio1_000023
KBio2_002515
KBio2_005083
KBio2_007651
KBio3_001766
KBio3_001902
KBio3_002993
KBioGR_001347
KBioGR_001684
KBioGR_002515
KBioSS_002523
Kemi
Kemi S
L000679
LS-122410
LS-184129
Lopac0_000896
Migrastat
MolPort-001-794-623
NCGC00015798-07
NCGC00024690-02
NCGC00024690-03
NINDS_000023
NSC91523
Naprilin
Obsidan
Obzidan
Oposim
Oprea1_304193
PDSP1_000767
PDSP1_001607
PDSP1_001608
PDSP2_000755
PDSP2_001591
PDSP2_001592
Prano-Puren
Pranolol
Prestwick0_000952
Prestwick1_000952
Prestwick2_000952
Prestwick3_000952
Pronovan
Propanalol
Propanix
Propanolol
Propanolol [INN-Spanish]
Prophylux
Propranalol
Propranolol
Propranolol (INN)
Propranolol (TN)
Propranolol Hcl
Propranolol Hcl Intensol
Propranolol Hydrochloride
Propranolol [INN:BAN]
Propranololo
Propranololo [DCIT]
Propranololum
Propranololum [INN-Latin]
Propranur
Proprasylyt
Pylapron
R,S-Propranolol Hydrochloride
Racemic propranolol
Rapynogen
Reducor
Reducor Line
Reducor line
SPBio_001361
SPBio_001658
SPBio_003093
STK735510
Sagittol
Sawatal
Servanolol
Sloprolol
Spectrum2_001301
Spectrum2_001699
Spectrum3_000883
Spectrum3_001071
Spectrum4_000974
Spectrum4_001222
Spectrum5_000751
Sumial
Tesnol
UNII-9Y8NXQ24VQ
b-Propranolol
beta-Propranolol
cMAP_000071
etalong
propranolol
propranololo
β-Propranolol
2Neurotransmitter Agents17734
3Adrenergic beta-Antagonists1154
4Adrenergic Antagonists1535
5Adrenergic Agents5140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Modified Instrumentation for Surgery to Correct TrichiasisUnknown statusNCT00886015Phase 3
2Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric TumorsCompletedNCT02334930
3Clinical Efficacy of Nail Brace for Treatment of Ingrown ToenailsNot yet recruitingNCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

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Anatomical Context for Pyogenic Granuloma

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MalaCards organs/tissues related to Pyogenic Granuloma:

35
Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Testes

Animal Models for Pyogenic Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Pyogenic Granuloma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5ACTC1, ANGPT1, ANGPT2, TEK, VEGFA
2MP:00053698.4ACTC1, ANGPT1, MTOR, TEK, VEGFA
3MP:00053918.1ANGPT1, ANGPT2, TEK, VEGFA
4MP:00053767.9ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA
5MP:00107687.9ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA

Publications for Pyogenic Granuloma

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Articles related to Pyogenic Granuloma:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. (27116335)
2016
2
CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature. (27420917)
2016
3
Capillary hemangioma or pyogenic granuloma. (27041829)
2016
4
Demographics and etiologic factors of nasal pyogenic granuloma. (27122134)
2016
5
Oral pyogenic granuloma gravidarum: A case report describing a large bleeding lingual lesion. (28019137)
2016
6
Angioleiomyoma of Gingiva Masquerading as Pyogenic Granuloma. (27504561)
2016
7
Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. (27210602)
2016
8
Extra-Gingival Pyogenic Granuloma Displacing Teeth. (27755424)
2016
9
A Rare Case of Pyogenic Granuloma with a Natal Tooth. (27891487)
2016
10
Nodular swelling on the lower lip; pyogenic granuloma. (25525490)
2014
11
Pyogenic granuloma of the gingiva: A misnomer? - A case report and review of literature. (24174735)
2013
12
Case of the month. Pyogenic granuloma. (23923461)
2013
13
Oral capillary haemangioma mimicking pyogenic granuloma: a challenge for diagnosis and management. (23417375)
2013
14
Painless red lesion on the tongue. Pyogenic granuloma. (22414511)
2012
15
Photodynamic therapy with 5-aminolevulinic acid intralesional injection for pyogenic granuloma. (22250252)
2012
16
Pyogenic granuloma - Hyperplastic lesion of the gingiva: case reports". (23091574)
2012
17
Pyogenic granuloma: treatment with the 1,064-nm long-pulsed neodymium-doped yttrium aluminum garnet laser in 20 patients. (22272571)
2012
18
A case of childhood subcutaneous pyogenic granuloma (lobular capillary hemangioma). (21196416)
2012
19
Pregnancy-associated pyogenic granuloma of the lip: a case report. (21970285)
2011
20
Pyogenic granuloma. (21119538)
2011
21
Pyogenic granuloma of the foot with satellitosis: a role for conservative management. (21291657)
2011
22
Pyogenic granuloma of the distal trachea: a case report. (23208576)
2011
23
Clinical inquiries. What's the best treatment for pyogenic granuloma? (20074501)
2010
24
Complete resolution of a recurrent giant pyogenic granuloma on the palm of the hand following single dose of intralesional bleomycin injection. (19632910)
2010
25
Congenital disseminated pyogenic granuloma. (19706097)
2009
26
Pyogenic granuloma: an unusual cause of massive gastrointestinal bleeding from the small bowel. (19373418)
2009
27
Pyogenic granuloma as a surrogate indicator of deep seated foreign bodies: a case report. (19918522)
2009
28
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
29
Extragingival pyogenic granuloma: a case report. (19055747)
2008
30
Nasal pyogenic granuloma. (17210349)
2007
31
Recurrent intraoral pyogenic granuloma with satellitosis treated with corticosteroids. (16390473)
2006
32
Diagnostic quiz. Case no. 1. Pyogenic granuloma. (19226729)
2006
33
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
34
Is pyogenic granuloma associated with Bartonella infection? (16310070)
2005
35
Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. (16005715)
2005
36
Chronic Staphylococcus aureus infection leading to pyogenic granuloma and preventing socket re-epithelialization after orbital exenteration. (15942503)
2005
37
Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. (14613084)
2003
38
Pediatric pyogenic granuloma of the glans penis. (12639669)
2003
39
Pyogenic granuloma-like lesions during capecitabine therapy. (12452889)
2002
40
Laryngeal pyogenic granulomas do not express oestrogen or progesterone receptors. (11667991)
2001
41
Onychomadesis and pyogenic granuloma following cast immobilization. (11176706)
2001
42
Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. (10929871)
2000
43
Pyogenic granuloma: a complication of transconjunctival incisions. (10744252)
2000
44
Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma. (10233658)
1999
45
Oral angiosarcoma misdiagnosed as a pyogenic granuloma. (9580135)
1998
46
Oral pyogenic granuloma in pregnancy. (9764875)
1995
47
Pyogenic granuloma following treatment of verruca vulgaris with cryotherapy and Duoplant. (2022132)
1991
48
Localized vs generalized pyogenic granuloma. A clinicopathologic study. (2036033)
1991
49
A pyogenic granuloma and an irritation fibroma--case report. (297013)
1979
50
Pyogenic granuloma of the nasal cavity. (13902293)
1962

Variations for Pyogenic Granuloma

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Expression for genes affiliated with Pyogenic Granuloma

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Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

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Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5ANGPT2, TEK
29.4ANGPT1, TEK
3
Show member pathways
8.9ANGPT1, ANGPT2, TEK
4
Show member pathways
8.9ANGPT1, ANGPT2, TEK
5
Show member pathways
8.8ANGPT1, ANGPT2, MTOR
68.6ANGPT1, TEK, VEGFA
7
Show member pathways
8.6ANGPT1, TEK, VEGFA
8
Show member pathways
8.4ANGPT1, ANGPT2, MTOR, TEK
9
Show member pathways
8.1ANGPT1, ANGPT2, TEK, VEGFA
10
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
11
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
127.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
137.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
14
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA

GO Terms for genes affiliated with Pyogenic Granuloma

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Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:000590210.0ANGPT1, TEK
2actin filamentGO:00058849.8ACTC1, TEK
3extracellular spaceGO:00056158.1ACTC1, ANGPT1, ANGPT2, VEGFA
4extracellular regionGO:00055767.8ANGPT1, ANGPT2, TEK, VEGFA

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell apoptotic processGO:200035210.1ANGPT1, TEK
2sprouting angiogenesisGO:000204010.0ANGPT1, TEK
3animal organ regenerationGO:003110010.0ANGPT2, TEK
4glomerulus vasculature developmentGO:007201210.0ANGPT1, ANGPT2
5negative regulation of angiogenesisGO:001652510.0ANGPT2, TEK
6maternal process involved in female pregnancyGO:006013510.0ANGPT2, MTOR
7positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.9ANGPT1, TEK
8positive regulation of focal adhesion assemblyGO:00518949.8TEK, VEGFA
9germ cell developmentGO:00072819.7ANGPT2, MTOR
10cardiac muscle contractionGO:00600489.7ACTC1, MTOR
11transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.7ANGPT1, TEK
12positive regulation of blood vessel endothelial cell migrationGO:00435369.7ANGPT1, VEGFA
13growthGO:00400079.7MTOR, VEGFA
14negative regulation of protein phosphorylationGO:00019339.7ANGPT1, MTOR
15Tie signaling pathwayGO:00480149.6ANGPT1, ANGPT2, TEK
16positive regulation of cell adhesionGO:00457859.5ANGPT1, VEGFA
17positive chemotaxisGO:00509189.5ANGPT1, VEGFA
18heart morphogenesisGO:00030079.5MTOR, VEGFA
19positive regulation of protein kinase B signalingGO:00518979.4ANGPT1, MTOR, TEK
20positive regulation of endothelial cell migrationGO:00105959.2ANGPT1, TEK, VEGFA
21positive regulation of peptidyl-serine phosphorylationGO:00331389.2ANGPT1, VEGFA
22leukocyte migrationGO:00509009.2ANGPT1, ANGPT2, TEK
23positive regulation of endothelial cell proliferationGO:00019389.2MTOR, TEK, VEGFA
24positive regulation of protein phosphorylationGO:00019349.2MTOR, TEK, VEGFA
25positive regulation of angiogenesisGO:00457669.1ANGPT2, TEK, VEGFA
26positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.9ANGPT1, MTOR, VEGFA
27positive regulation of receptor internalizationGO:00020928.7ANGPT1, VEGFA
28response to hypoxiaGO:00016668.7ANGPT2, TEK, VEGFA
29positive regulation of gene expressionGO:00106288.6ACTC1, MTOR, VEGFA
30angiogenesisGO:00015258.4ANGPT1, ANGPT2, TEK, VEGFA
31negative regulation of apoptotic processGO:00430668.3ACTC1, ANGPT1, TEK, VEGFA

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.3ANGPT1, ANGPT2

Sources for Pyogenic Granuloma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet