MCID: PYG006
MIFTS: 41

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 50 69
Lobular Capillary Hemangioma 50
Granuloma Pyogenic 52

Classifications:



External Ids:

ICD10 33 L98.0

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 50 pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to cutaneous leishmaniasis and rheumatoid arthritis. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Propranolol and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 cutaneous leishmaniasis 29.1 ANGPT2 TEK VEGFA
2 rheumatoid arthritis 28.2 ANGPT1 TEK VEGFA
3 hemangioma 10.3
4 capillary hemangioma 10.3
5 cutaneous mucoepidermoid carcinoma 10.3 ANGPT1 TEK
6 macular dystrophy, atypical vitelliform 10.2 ANGPT1 ANGPT2
7 sydenham chorea 10.2 ANGPT1 ANGPT2
8 sarcoma 10.2
9 vesiculobullous skin disease 10.2 TEK VEGFA
10 submucous uterine fibroid 10.1 ANGPT2 VEGFA
11 bipolar i disorder 10.1 ANGPT2 VEGFA
12 lichen planus 10.1 TEK VEGFA
13 malignant granular cell skin tumor 10.1 ANGPT2 VEGFA
14 burns 10.1
15 melanoma 10.0
16 subdural empyema 10.0 TEK VEGFA
17 pituitary infarct 10.0 TEK VEGFA
18 fibroma 10.0
19 esophagitis 10.0
20 chikungunya 10.0 TEK VEGFA
21 paronychia 10.0
22 ossifying fibroma 10.0
23 gingivitis 10.0
24 hepatocellular carcinoma 9.9
25 endotheliitis 9.9
26 neuropathy, hereditary sensory and autonomic, type vi 9.9 ANGPT2 VEGFA
27 hyperpituitarism 9.9 ACTC1 TEK
28 testicular leydig cell tumor 9.9 ANGPT1 ANGPT2 TEK
29 kaposi sarcoma 9.8
30 acne 9.8
31 lymphoma 9.8
32 bacillary angiomatosis 9.8
33 basal cell carcinoma 9.8
34 amelanotic melanoma 9.8
35 hemangioendothelioma 9.8
36 weber syndrome 9.8
37 angiomatosis 9.8
38 vernal conjunctivitis 9.8 ANGPT2 VEGFA
39 iridogoniodysgenesis and skeletal anomalies 9.8 ACTC1 VEGFA
40 breast cancer 9.8
41 anaplastic large cell lymphoma 9.8
42 leukemia 9.8
43 angiosarcoma 9.8
44 squamous cell carcinoma 9.8
45 vaginitis 9.8
46 laryngitis 9.8
47 epulis 9.8
48 periodontitis 9.8
49 gigantism 9.8
50 renal fibrosis 9.7 ANGPT2 TEK VEGFA

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ANGPT1 ANGPT2 MTOR TEK VEGFA ACTC1
2 homeostasis/metabolism MP:0005376 9.63 ACTC1 ANGPT1 ANGPT2 MTOR TEK VEGFA
3 mortality/aging MP:0010768 9.43 ACTC1 ANGPT1 ANGPT2 MTOR TEK VEGFA
4 muscle MP:0005369 9.02 ANGPT1 MTOR TEK VEGFA ACTC1

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Adrenergic Agents
3 Adrenergic Antagonists
4 Adrenergic beta-Antagonists
5 Neurotransmitter Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
2 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
3 Maximizing Trichiasis Surgery Success Recruiting NCT03100747
4 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Not yet recruiting NCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

39
Skin, Tongue, Bone, Colon, Endothelial, Bone Marrow, Testes

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 601)
id Title Authors Year
1
Treatment of paediatric facial pyogenic granuloma with topical ingenol mebutate. ( 28691181 )
2017
2
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
3
Pyogenic Granuloma: A Retrospective Analysis of Cases Treated Over a 10-Year. ( 28913297 )
2017
4
Pyogenic granuloma-like lesion in children: Should we wait? ( 28615821 )
2017
5
Pyogenic Granuloma of the Esophagus. ( 28351792 )
2017
6
Pyogenic Granuloma in an Unusual Site. ( 28491928 )
2017
7
Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options. ( 28785323 )
2017
8
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis. ( 28658902 )
2017
9
Pyogenic Granuloma of the Penis: An Uncommon Lesion with Unusual Presentation. ( 28413384 )
2017
10
Image Gallery: Haemorrhagic shock due to a cutaneous pyogenic granuloma. ( 28833014 )
2017
11
Lobular capillary hemangioma (pyogenic granuloma) of the oral cavity. ( 28719705 )
2017
12
Optic Disc Pyogenic Granuloma. ( 28868280 )
2017
13
Cutaneous epithelioid hemangioendothelioma on the sole mimicking a pyogenic granuloma. ( 28664615 )
2017
14
Combined method to treat periungual pyogenic granuloma: Nail corner plasty, taping and topical bismuth subgallate. ( 28464348 )
2017
15
Pyogenic granuloma of the penis following chancre. ( 28850727 )
2017
16
Giant pyogenic granuloma of theA finger in an HIV-positive patient. ( 28556978 )
2017
17
Intravenous lobular capillary haemangioma (pyogenic granuloma): A case report and a review of imaging findings as reported in the literature. ( 28861947 )
2017
18
Pyogenic Granuloma of the Conjunctiva. ( 28445671 )
2017
19
Dermoscopy of pyogenic granuloma. ( 28819531 )
2017
20
Malignant fibrous histiocytoma masquerading as pyogenic granuloma. ( 28388346 )
2017
21
Periungual Pyogenic Granuloma: The Importance of the Medical History. ( 27386461 )
2016
22
Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision. ( 27258719 )
2016
23
Treatment of pediatric pyogenic granuloma in a functionally and cosmetically sensitive area with the 1064nm ND:Yag laser. ( 27617472 )
2016
24
Recurrent Pyogenic Granuloma Around Dental Implants: A Rare Case Report. ( 27333016 )
2016
25
Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report. ( 26889266 )
2016
26
Agminated eruptive pyogenic granuloma on chin following redundant needle injections. ( 26813235 )
2016
27
Angioleiomyoma of Gingiva Masquerading as Pyogenic Granuloma. ( 27504561 )
2016
28
The Histopathological Spectrum of Pyogenic Granuloma: A Case Series. ( 27382492 )
2016
29
CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature. ( 27420917 )
2016
30
Is timolol an effective treatment for pyogenic granuloma? ( 26872444 )
2016
31
A Rare Case of Pyogenic Granuloma with a Natal Tooth. ( 27891487 )
2016
32
Oral pyogenic granuloma gravidarum: A case report describing a large bleeding lingual lesion. ( 28019137 )
2016
33
Pyogenic granuloma of the jejunum; diagnosis and treatment with double-balloon enteroscopy: A case report. ( 27161794 )
2016
34
Pyogenic granuloma possibly associated with capecitabine therapy. ( 27864844 )
2016
35
Pyogenic Granuloma-Like Kaposi's Sarcoma. ( 27072065 )
2016
36
Pyogenic granuloma of the duodenum. ( 26948163 )
2016
37
Expression of embryonic stem cell markers in pyogenic granuloma. ( 27509392 )
2016
38
Management of a Recurrent Pyogenic Granuloma of the Hard Palate with Diode Laser: A Case Report. ( 27330700 )
2016
39
Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature. ( 27192522 )
2016
40
Timolol for the treatment of pyogenic granuloma (PG) in children. ( 27543231 )
2016
41
Pyogenic Granuloma on the Upper Lip: A Rare Location. ( 27997445 )
2016
42
Squamous cell carcinoma of the nail fold masquerading as pyogenic granuloma. ( 27241502 )
2016
43
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. ( 27116335 )
2016
44
BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. ( 26802240 )
2016
45
Capillary hemangioma or pyogenic granuloma. ( 27041829 )
2016
46
Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser. ( 27874157 )
2016
47
Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia. ( 27403353 )
2016
48
Oral Pathology Quiz #90. Case Number 4. Pyogenic granuloma. ( 27159943 )
2016
49
Pyogenic granuloma-like basal cell carcinoma on the abdomen: A deceptive presentation. ( 27730056 )
2016
50
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016

Variations for Pyogenic Granuloma

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ANGPT1 ANGPT2 MTOR TEK VEGFA
2
Show member pathways
13.19 ANGPT1 ANGPT2 MTOR TEK VEGFA
3
Show member pathways
13.07 ANGPT1 ANGPT2 MTOR TEK VEGFA
4
Show member pathways
12.99 ANGPT1 ANGPT2 MTOR TEK
5
Show member pathways
12.9 ANGPT1 ANGPT2 TEK VEGFA
6
Show member pathways
12.31 ANGPT1 ANGPT2 TEK VEGFA
7
Show member pathways
12.2 ANGPT1 ANGPT2 TEK
8 12.19 ANGPT1 ANGPT2 MTOR TEK VEGFA
9
Show member pathways
11.83 ANGPT1 ANGPT2 TEK
10 11.5 ANGPT2 TEK
11 11.45 ANGPT1 TEK VEGFA
12 11.23 MTOR TEK
13 11.05 ANGPT1 TEK
14 11.02 ANGPT1 ANGPT2 MTOR TEK VEGFA
15 10.9 ANGPT1 ANGPT2 VEGFA
16 10.51 ANGPT1 TEK VEGFA

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.96 ACTC1 TEK
2 microvillus GO:0005902 8.62 ANGPT1 TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 ACTC1 MTOR VEGFA
2 negative regulation of apoptotic process GO:0043066 9.76 ACTC1 ANGPT1 TEK VEGFA
3 leukocyte migration GO:0050900 9.72 ANGPT1 ANGPT2 TEK
4 response to hypoxia GO:0001666 9.69 ANGPT2 TEK VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.67 MTOR TEK VEGFA
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.64 ANGPT1 VEGFA
7 negative regulation of angiogenesis GO:0016525 9.64 ANGPT2 TEK
8 negative regulation of protein phosphorylation GO:0001933 9.63 ANGPT1 MTOR
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 ANGPT1 TEK
10 heart morphogenesis GO:0003007 9.62 MTOR VEGFA
11 positive regulation of cell adhesion GO:0045785 9.61 ANGPT1 VEGFA
12 cardiac muscle contraction GO:0060048 9.61 ACTC1 MTOR
13 positive regulation of angiogenesis GO:0045766 9.61 ANGPT2 TEK VEGFA
14 positive chemotaxis GO:0050918 9.6 ANGPT1 VEGFA
15 germ cell development GO:0007281 9.59 ANGPT2 MTOR
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ANGPT1 TEK
17 sprouting angiogenesis GO:0002040 9.58 ANGPT1 TEK
18 positive regulation of protein kinase B signaling GO:0051897 9.58 ANGPT1 MTOR TEK
19 maternal process involved in female pregnancy GO:0060135 9.57 ANGPT2 MTOR
20 positive regulation of focal adhesion assembly GO:0051894 9.56 TEK VEGFA
21 positive regulation of receptor internalization GO:0002092 9.54 ANGPT1 VEGFA
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 ANGPT1 MTOR VEGFA
23 positive regulation of blood vessel endothelial cell migration GO:0043536 9.52 ANGPT1 VEGFA
24 positive regulation of endothelial cell proliferation GO:0001938 9.5 MTOR TEK VEGFA
25 growth GO:0040007 9.48 MTOR VEGFA
26 angiogenesis GO:0001525 9.46 ANGPT1 ANGPT2 TEK VEGFA
27 positive regulation of endothelial cell migration GO:0010595 9.43 ANGPT1 TEK VEGFA
28 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
29 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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