Pyogenic Granuloma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pyogenic Granuloma

Sources:
⁴²NIH Rare Diseases, ⁶⁴Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards based summary: Pyogenic Granuloma, also known as hemangioma, lobular capillary, is related to hemangioendothelioma and kaposi's sarcoma. An important gene associated with Pyogenic Granuloma is ANGPT2 (angiopoietin 2), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and HIF-1 signaling pathway. The compounds glycosaminoglycan and infliximab have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:⁶⁴ Pyogenic granuloma (also known as a \"Eruptive hemangioma\", \"Granulation tissue-type hemangioma\",... more...

Aliases & Classifications for Pyogenic Granuloma

Sources:
⁴²NIH Rare Diseases, ⁶¹UMLS, ⁴⁴Novoseek, ²⁶ICD10
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Pyogenic Granuloma, Aliases & Descriptions:

Name: Pyogenic Granuloma ⁴² ⁶¹

Hemangioma, Lobular Capillary ⁶¹

Lobular Capillary Hemangioma ⁴²

Granuloma Pyogenic ⁴⁴

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases

ICD10: ²⁶

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Other disorders of skin and subcutaneous tissue, not elsewhere classified

Pyogenic granuloma

External Ids:

ICD10²⁶ L98.0

Related Diseases for Pyogenic Granuloma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 106)

id	Related Disease	Score	Top Affiliating Genes
1	hemangioendothelioma	30.8	PLG
2	kaposi's sarcoma	30.7	PECAM1, TEK
3	hemangioma	30.6	ACTC1, ANGPT2, PECAM1, TEK
4	sarcoma	30.3	ACTC1, ANGPT2, PECAM1, TEK
5	angiosarcoma	29.8	TEK, PECAM1, ANGPT2, ACTC1
6	arthritis	29.8	PLG, PECAM1, TEK
7	melanoma	29.7	TEK, PECAM1, ANGPT2, ACTC1, PLG
8	leukemia	29.7	PLG, ANGPT2, PECAM1, TEK
9	breast cancer	29.7	TEK, PECAM1, ANGPT2, PLG
10	rheumatoid arthritis	29.5	TEK, PECAM1, ANGPT2, PLG
11	capillary hemangioma	10.7
12	burns	10.5
13	fibroma	10.5
14	esophagitis	10.5
15	ossifying fibroma	10.5
16	paronychia	10.5
17	hepatocellular carcinoma	10.4
18	gingivitis	10.4
19	endotheliitis	10.4
20	malaria	10.3	PECAM1
21	sturge-weber syndrome	10.3
22	weber syndrome	10.3
23	angiomatosis	10.3
24	asthma	10.3
25	inverted papilloma	10.3
26	papilloma	10.3
27	acne	10.3
28	barrett's esophagus	10.3
29	amelanotic melanoma	10.3
30	basal cell carcinoma	10.3
31	epulis	10.3
32	laryngitis	10.3
33	periodontitis	10.3
34	vaginitis	10.3
35	gigantism	10.3
36	lymphangioma	10.1	ACTC1, PECAM1
37	chronic lymphocytic leukemia	10.1
38	cutaneous leishmaniasis	10.1
39	dentin dysplasia	10.1
40	graft versus host disease	10.1
41	multiple myeloma	10.1
42	pemphigus vulgaris	10.1
43	renal cell carcinoma	10.1
44	congenital epulis	10.1
45	pleomorphic adenoma	10.1
46	pemphigus	10.1
47	epidermolytic hyperkeratosis	10.1
48	rosacea	10.1
49	microphthalmia	10.1
50	intussusception	10.1

Graphical network of the top 20 diseases related to Pyogenic Granuloma:

Symptoms for Pyogenic Granuloma

Drugs & Therapeutics for Pyogenic Granuloma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pyogenic Granuloma

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Pyogenic Granuloma:

³²

Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Testes, Trachea, Kidney, Adrenal gland, Breast, T cells

Animal Models for Pyogenic Granuloma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Pyogenic Granuloma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	8.8	PLG, ANGPT2, PECAM1
2	digestive/alimentary phenotype	MP:0005381	8.6	PECAM1, ANGPT2, PLG
3	muscle phenotype	MP:0005369	8.5	ACTC1, PECAM1, TEK
4	cellular phenotype	MP:0005384	8.0	TEK, PECAM1, ACTC1, PLG
5	cardiovascular system phenotype	MP:0005385	7.6	PLG, ACTC1, ANGPT2, PECAM1, TEK
6	homeostasis/metabolism phenotype	MP:0005376	7.6	TEK, PECAM1, ANGPT2, ACTC1, PLG

Publications for Pyogenic Granuloma

Sources:
⁵¹PubMed
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Articles related to Pyogenic Granuloma:

(show top 50) (show all 512)

id	Title	Authors	Year
1	Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)	Luna S.A.... Camacho-Martinez F.	2014
2	Pyogenic granuloma of the ileum diagnosed by double-balloon enteroscopy. (25224187)	Kikuchi A.... Imaeda H.	2014
3	Pyogenic granuloma of the gingiva: A misnomer? - A case report and review of literature. (24174735)	Gomes S.R.... Tavadia J.K.	2013
4	Case of the month. Pyogenic granuloma. (23923461)	Robledo J.... Rominger J.W.	2013
5	Esophageal pyogenic granuloma: endosonographic findings and endoscopic treatments. (23423701)	Seoung H.G.... Park C.J.	2013
6	Oral capillary haemangioma mimicking pyogenic granuloma: a challenge for diagnosis and management. (23417375)	Patil A.... Huddar S.B.	2013
7	Pyogenic granuloma satellite of deep infection: tuberculous osteitis. (23647787)	Karbout N.... Akhdari N.	2013
8	Dermoscopic and histological correlation of an atypical case of pyogenic granuloma. (23488571)	Lacarrubba F.... Micali G.	2013
9	Painless red lesion on the tongue. Pyogenic granuloma. (22414511)	Brooks J.K.... Nikitakis N.G.	2012
10	Exuberant pyogenic granuloma in extragingival site. (22936151)	Costa F.W.... Pereira K.M.	2012
11	Photodynamic therapy with 5-aminolevulinic acid intralesional injection for pyogenic granuloma. (22250252)	Lee D.J.... Kim Y.C.	2012
12	Giant cell tumor of tendon sheath mimicking pyogenic granuloma in the index finger pulp: a case report. (22351549)	Jerome J.T.... Sridhar R.	2012
13	"Pyogenic granuloma - Hyperplastic lesion of the gingiva: case reports". (23091574)	Verma P.K.... Singh A.	2012
14	Concurrent occurrence of mucocele and pyogenic granuloma. (22028553)	Kim J.H.... Ahn S.K.	2011
15	Pregnancy-associated pyogenic granuloma of the lip: a case report. (21970285)	Adeyemo W.L.... Ajayi O.F.	2011
16	Clinical inquiries. What's the best treatment for pyogenic granuloma? (20074501)	Gilmore A.... Safranek S.	2010
17	Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population. (20417014)	GordA^n-NA_A+ez M.A.... GalvALo H.C.	2010
18	Oral pathology quiz. Case number 2. Pyogenic granuloma. (20658767)		2010
19	Multiple pyogenic granuloma of the penis in a four-year-old child: a case report. (19918487)	Spinelli C.... Pingitore R.	2009
20	Congenital disseminated pyogenic granuloma. (19706097)	Browning J.C.... Bree A.F.	2009
21	Pyogenic granuloma: an unusual cause of massive gastrointestinal bleeding from the small bowel. (19373418)	Moffatt D.C.... Singh H.	2009
22	Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)	das Chagas M.S.... Maia L.C.	2009
23	Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)	Salum F.G.... Nicola F.S.	2008
24	Extragingival pyogenic granuloma: a case report. (19055747)	Amirchaghmaghi M.... Mozafari P.M.	2008
25	Successful treatment of a therapy-resistant pyogenic granuloma with topical imiquimod 5% cream. (16766338)	Goldenberg G.... Jorizzo J.L.	2006
26	Comparison of cryotherapy and curettage for the treatment of pyogenic granuloma: a randomized trial. (16536810)	Ghodsi S.Z.... Farnaghi F.	2006
27	Recurrent intraoral pyogenic granuloma with satellitosis treated with corticosteroids. (16390473)	Parisi E.... Glick M.	2006
28	Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)	Ghekiere O.... Vande Berg B.	2005
29	Is pyogenic granuloma associated with Bartonella infection? (16310070)	Levy I.... Ben-Amitai D.	2005
30	Metastatic hepatocellular carcinoma of gingiva mimicking pyogenic granuloma. (12894096)	Rim J.H.... Kim J.A.	2003
31	Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. (14613084)	Al-Khateeb T.... Ababneh K.	2003
32	Pediatric pyogenic granuloma of the glans penis. (12639669)	Eickhorst K.M.... Barone J.G.	2003
33	Pyogenic granuloma-like lesions during capecitabine therapy. (12452889)	Piguet V.... Borradori L.	2002
34	Laryngeal pyogenic granulomas do not express oestrogen or progesterone receptors. (11667991)	Marrinan M.S.... Wasserman P.	2001
35	Onychomadesis and pyogenic granuloma following cast immobilization. (11176706)	Tosti A.... Camacho-Martinez F.	2001
36	Pyogenic granuloma: who are you? (11495513)	Grosshans E.	2001
37	Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. (10929871)	Yuan K.... Lin M.T.	2000
38	Pyogenic granuloma: a complication of transconjunctival incisions. (10744252)	Fryer R.H.... Reinke K.R.	2000
39	Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma. (10233658)	Kubota Y.... Nakayama J.	1999
40	Multiple pyogenic granuloma demonstrated by SPECT using 99Tcm-labelled red blood cells. (10474504)	Lin K.J.... Tzen K.Y.	1999
41	Plaque radiation therapy for recurrent conjunctival pyogenic granuloma. (9565059)	GA1ndA1z K.... Zhao D.Y.	1998
42	Pyogenic granuloma of the cornea. (9630306)	Papadopoulos M.... McKelvie P.A.	1998
43	Oral angiosarcoma misdiagnosed as a pyogenic granuloma. (9580135)	MuA+oz M.... MartA-n-Granizo R.	1998
44	The late development of oral pyogenic granuloma as a complication of pregnancy: a case report. (9051984)	Silverstein L.H.... Singh B.B.	1996
45	Oral pyogenic granuloma in pregnancy. (9764875)	Silverstein L.H.... Singh B.B.	1995
46	Intraoral pyogenic granuloma after allogeneic bone marrow transplant. Report of three cases. (7838468)	Lee L.... Rotstein L.E.	1994
47	Pyogenic granuloma following treatment of verruca vulgaris with cryotherapy and Duoplant. (2022132)	Kolbusz R.V.... O'Donoghue M.N.	1991
48	The pyogenic granuloma. (6393917)	Bucci F.A.... Wiener B.D.	1984
49	A pyogenic granuloma and an irritation fibroma--case report. (297013)	Meister F.... Bell W.A.	1979
50	Pyogenic granuloma of the nasal cavity. (13902293)	GROSSMAN J.W.... CRAMER O.S.	1962

Genes related to Pyogenic Granuloma

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¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Pyogenic Granuloma:

- Elite gene

id	Symbol	Description	Score	Implication
1	ANGPT2	angiopoietin 2	22.04	GeneCards inferred via : Publications (show sections)
2	ACTC1	actin, alpha, cardiac muscle 1	18.04	GeneCards inferred via : Publications (show sections)
3	PECAM1	platelet/endothelial cell adhesion molecule 1	14.04	GeneCards inferred via : Publications (show sections)
4	TEK	TEK tyrosine kinase, endothelial	10.04	GeneCards inferred via : Publications (show sections)
5	PLG	plasminogen	6.04	GeneCards inferred via : Publications (show sections)

Products for genes related to Pyogenic Granuloma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	5	5
2	Novus Biologicals	5	5	5	-

Variations for Pyogenic Granuloma

Expression for genes affiliated with Pyogenic Granuloma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁰KEGG, ⁵Cell Signaling Technology, ⁵⁹Thomson Reuters, ³⁷NCBI BioSystems Database, ⁵²QIAGEN
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Pathways related to Pyogenic Granuloma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+⁵⁴ Show member pathways Platelet degranulation⁵⁴ Disinhibition of SNARE formation⁵⁴	9.3	PECAM1, PLG
2	HIF-1 signaling pathway³⁰	9.2	ANGPT2, TEK
3	Tyrosine Kinases / Adaptors⁵	9.2	ANGPT2, TEK
4	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	8.7	PLG, ANGPT2, TEK
5	Angiogenesis⁵	8.6	ANGPT2, PECAM1, TEK
6	Cell surface interactions at the vascular wall⁵⁴ Show member pathways Tie2 Signaling⁵⁴ PECAM1 interactions⁵⁴	8.6	TEK, PECAM1, ANGPT2
7	Hemostasis⁵⁴ Show member pathways Platelet activation, signaling and aggregation⁵⁴	8.1	PLG, ANGPT2, PECAM1, TEK

Compounds for genes affiliated with Pyogenic Granuloma

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ¹²DrugBank, ²⁵HMDB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
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Compounds related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	glycosaminoglycan⁴⁴	9.4	PECAM1, ACTC1
2	infliximab⁴⁴ ⁵⁰ ¹²	11.4	ANGPT2, TEK
3	formaldehyde⁴⁴ ²⁵	10.3	ACTC1, PECAM1
4	steroid⁴⁴	9.2	ANGPT2, ACTC1, PLG
5	hematoxylin⁴⁴	9.1	PLG, ACTC1, PECAM1
6	fibrinogen⁴⁴	9.1	PLG, ANGPT2, PECAM1
7	cyclosporin a⁴⁴ ²⁹ ⁶⁰	11.1	PECAM1, ANGPT2, ACTC1
8	p002⁴⁴	9.1	PECAM1, TEK
9	estrogen⁴⁴	8.9	PECAM1, ANGPT2, ACTC1
10	retinoic acid⁴⁴ ²⁵	9.8	ACTC1, ANGPT2, PECAM1
11	glucose⁴⁴	8.6	PECAM1, ANGPT2, ACTC1, PLG
12	atp⁴⁴ ²⁹	9.6	PLG, ANGPT2, PECAM1
13	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	11.5	PLG, ACTC1, ANGPT2, PECAM1
14	ribonucleic acid⁴⁴	8.4	ACTC1, ANGPT2, PECAM1, TEK
15	paraffin⁴⁴	8.4	TEK, PECAM1, ANGPT2, ACTC1
16	thymidine⁴⁴ ²⁵	9.4	TEK, PECAM1, ANGPT2, PLG
17	nitric oxide⁴⁴ ²⁵ ¹²	10.3	PLG, ANGPT2, PECAM1, TEK
18	cysteine⁴⁴	8.3	TEK, PECAM1, ANGPT2, PLG
19	serine⁴⁴	8.3	PLG, ANGPT2, PECAM1, TEK
20	matrigel⁴⁴	7.9	PLG, ACTC1, ANGPT2, PECAM1, TEK
21	vegf⁴⁴	7.9	TEK, PECAM1, ANGPT2, ACTC1, PLG
22	oxygen⁴⁴ ²⁵	8.9	TEK, PECAM1, ANGPT2, ACTC1, PLG
23	tyrosine⁴⁴	7.8	TEK, PECAM1, ANGPT2, ACTC1, PLG

GO Terms for genes affiliated with Pyogenic Granuloma

Sources:
¹⁷Gene Ontology
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Cellular components related to Pyogenic Granuloma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:072562	9.1	ACTC1, PLG
2	actin filament	GO:005884	9.0	ACTC1, TEK
3	extracellular space	GO:005615	8.4	PLG, ACTC1, ANGPT2, PECAM1
4	plasma membrane	GO:005886	8.1	PLG, ANGPT2, PECAM1, TEK

Biological processes related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-substrate adhesion	GO:010812	9.7	PLG, ANGPT2
2	Tie signaling pathway	GO:048014	9.5	ANGPT2, TEK
3	platelet degranulation	GO:002576	9.4	PLG, PECAM1
4	organ regeneration	GO:031100	9.4	ANGPT2, TEK
5	negative regulation of angiogenesis	GO:016525	9.3	TEK, ANGPT2
6	platelet activation	GO:030168	9.3	PLG, PECAM1
7	positive regulation of angiogenesis	GO:045766	9.3	ANGPT2, TEK
8	response to hypoxia	GO:001666	9.1	ANGPT2, TEK
9	angiogenesis	GO:001525	8.9	ANGPT2, TEK
10	leukocyte migration	GO:050900	8.8	TEK, PECAM1, ANGPT2
11	signal transduction	GO:007165	8.6	TEK, PECAM1, ANGPT2
12	blood coagulation	GO:007596	8.3	PLG, ANGPT2, PECAM1, TEK

Products for genes affiliated with Pyogenic Granuloma

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Sources for Pyogenic Granuloma

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: PYG006 MIFTS: 49	Pyogenic Granuloma malady Rare diseases, Skin diseases categories
5 genes, 12 tissues, 106 related diseases, clinical trials Download this MalaCard Expand all tables

Pyogenic Granuloma malady