MCID: PYG006
MIFTS: 41

Pyogenic Granuloma malady

Skin diseases category

Summaries for Pyogenic Granuloma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to hemangioma and capillary hemangioma. An important gene associated with Pyogenic Granuloma is ANGPT2 (angiopoietin 2), and among its related pathways are Cell adhesion Plasmin signaling and Glioma. The compounds fumagillin and heparin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Wikipedia:63 Pyogenic granuloma (also known as a \"Eruptive hemangioma\", \"Granulation tissue-type hemangioma\",... more...

Aliases & Classifications for Pyogenic Granuloma

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42NIH Rare Diseases, 60UMLS, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pyogenic granuloma 42 60
lobular capillary hemangioma 42
granuloma pyogenic 44


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ICD1025 L98.0

Related Diseases for Pyogenic Granuloma

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17GeneCards, 18GeneDecks
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Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.0PECAM1, TEK, ACTC1, SLC2A1, THBS1, FGF2
2capillary hemangioma31.0SLC2A1
3sarcoma30.8TP63, PECAM1, TEK, ACTC1, ANGPT2, MTOR
4kaposi's sarcoma30.6PECAM1, TEK, FGF2, VEGFA
5gingivitis30.5DSPP
6hepatocellular carcinoma30.4TP73, TEK, SLC2A1, PLG, FGF2, EPHB4
7melanoma30.4TP73, TP63, PECAM1, TEK, ACTC1, THBS1
8papilloma30.3TP73, TP63, ACTC1
9angiosarcoma30.3PECAM1, TEK, ACTC1, VWF, ANGPT2, ANGPT1
10breast cancer30.2TP73, TP63, PECAM1, TEK, SLC2A1, THBS1
11conjunctivitis30.0PLG
12neurofibroma30.0TP73, ACTC1
13arteriovenous malformation30.0PECAM1, SLC2A1
14arthritis30.0PECAM1, TEK, THBS1, PLG, FGF2, ANGPT1
15adenoma30.0TP73, TP63, ACTC1, SLC2A1, THBS1, ANGPT2
16myeloma30.0FGF2, ANGPT2, VEGFA, MTOR, STAT3
17rheumatoid arthritis30.0PECAM1, TEK, PLG, ANGPT2, ANGPT1, DSPP
18leukemia30.0TP73, PECAM1, TEK, PLG, FGF2, ANGPT2
19squamous cell carcinoma30.0TP73, TP63, PECAM1, TEK, ACTC1, SLC2A1
20burns10.4
21orbital granuloma10.4
22esophagitis10.4
23paronychia10.4
24ossifying fibroma10.4
25acquired hemangioma10.2
26hemangioma of liver10.2
27nasal cavity inverting papilloma10.2
28central nervous system hemangioma10.2
29inverted papilloma10.2
30amelanotic melanoma10.2
31barrett's esophagus10.2
32acne10.2
33basal cell carcinoma10.2
34epulis10.2
35laryngitis10.2
36periodontitis10.2
37graft versus host disease10.0
38hemangioma of subcutaneous tissue10.0
39pleomorphic adenoma10.0
40mast-cell sarcoma10.0
41congenital epulis10.0
42clear cell acanthoma10.0
43rosacea10.0
44epidermolytic hyperkeratosis10.0
45cornea squamous cell carcinoma10.0
46giant hemangioma10.0
47pemphigus10.0
48intussusception10.0
49microphthalmia10.0
50chronic canaliculitis10.0

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to pyogenic granuloma

Clinical Features for Pyogenic Granuloma

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Drugs & Therapeutics for Pyogenic Granuloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pyogenic Granuloma

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Anatomical Context for Pyogenic Granuloma

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32MalaCards
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MalaCards organs/tissues related to Pyogenic Granuloma:

32
Skin

Animal Models for Pyogenic Granuloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pyogenic Granuloma:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7STAT3, PLG, TP73
2MP:00053699.4FGF2, ACTC1, THBS1, EPHB4, ANGPT1
3MP:00053679.3THBS1, PECAM1, EFNB2, ANGPT1, PLG
4MP:00053899.2TP73, VEGFA, THBS1, PLG, STAT3
5MP:00107719.0ANGPT2, PLG, EFNB2, VEGFA, STAT3
6MP:00053918.7ANGPT2, EFNB2, FGF2, PLG, THBS1, ATF2
7MP:00053708.6VEGFA, PLG, STAT3, ATF2, THBS1, PECAM1
8MP:00036318.5EFNB2, PLG, ATF2, SLC2A1, STAT3, TP73
9MP:00053808.3EPHB4, TP63, SLC2A1, PGR, ATF2, EFNB2
10MP:00053768.1ATF2, MTOR, EFNB2, PGR, PECAM1, PLG
11MP:00020067.9THBS1, TP73, STAT3, ATF2, VEGFA, FGF2
12MP:00053817.8VWF, THBS1, PECAM1, TP73, TP63, EFNB2
13MP:00053907.5STAT3, ATF2, MTOR, VEGFA, EFNB2, FGF2
14MP:00053887.4PECAM1, STAT3, ATF2, MTOR, THBS1, EFNB2
15MP:00028737.2TP63, PGR, ACTC1, EFNB2, VEGFA, MTOR
16MP:00053866.9EFNB2, FGF2, PGR, SLC2A1, TP73, TP63
17MP:00053976.8TP73, PGR, FGF2, STAT3, ATF2, MTOR
18MP:00053856.7TP73, STAT3, ATF2, ANGPT1, ANGPT2, EFNB2
19MP:00053876.6VWF, MTOR, VEGFA, PGR, EFNB2, PLG
20MP:00053786.3ACTC1, VEGFA, SLC2A1, THBS1, PLG, EPHB4
21MP:00053845.9SLC2A1, EFNB2, VWF, VEGFA, TEK, MTOR
22MP:00107685.2VWF, PLG, THBS1, SLC2A1, ACTC1, TEK

Publications for Pyogenic Granuloma

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Genetic Variations for Pyogenic Granuloma

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Expression for genes affiliated with Pyogenic Granuloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

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12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PLG
2
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10.2MTOR
310.0TEK, ANGPT1
410.0EFNB2
5
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9.9TP63, TP73
6
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9.9TP63, TP73
79.8TEK, ANGPT1, ANGPT2
89.8THBS1, FGF2, PLG
99.7PECAM1, ANGPT1, ANGPT2, TEK
10
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9.6FGF2, VWF, PECAM1
119.6MTOR, STAT3, SLC2A1
129.5EPHB4, EFNB2
13
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9.4TEK, ANGPT2, ANGPT1, EPHB4
149.3FGF2, SLC2A1, STAT3, MTOR
159.3TEK, FGF2, VEGFA, ANGPT1
16
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9.3VWF, PLG, THBS1, TEK, PECAM1
17
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9.3FGF2, PGR, MTOR, STAT3
18
Immune response IFN gamma signaling pathway
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9.2MTOR, STAT3, ATF2
19
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9.2STAT3, ATF2, MTOR
20
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9.2STAT3, ATF2, MTOR
21
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9.2VWF, STAT3, VEGFA, THBS1
22
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9.2FGF2, MTOR, PLG, THBS1, STAT3
239.1PECAM1, FGF2, ANGPT2, TEK, EFNB2
24
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9.1VWF, THBS1, PECAM1, PLG, VEGFA
25
Development PDGF signaling via STATs and NF-kB
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9.1STAT3, TEK, PLG, FGF2, ANGPT1, ANGPT2
26
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9.0TP73, STAT3, MTOR, VEGFA, SLC2A1
27
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9.0PLG, STAT3, THBS1, ATF2, PECAM1
289.0STAT3, MTOR, THBS1, FGF2, VEGFA
298.9STAT3, TP63, THBS1, MTOR, VEGFA
30
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8.7ATF2, ANGPT1, ANGPT2, TEK, FGF2, SLC2A1
31
Translation Insulin regulation of translation
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8.6MTOR, PLG, VEGFA, STAT3, ATF2
328.6STAT3, MTOR, VEGFA, ANGPT1, SLC2A1, ANGPT2
33
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8.2STAT3, TEK, FGF2, EPHB4, ANGPT2, ANGPT1
34
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8.2STAT3, ATF2, ANGPT1, ANGPT2, EPHB4, FGF2
35
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8.2ANGPT1, EPHB4, ANGPT2, FGF2, TEK, STAT3
36
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7.9FGF2, MTOR, STAT3, PGR, VWF, PLG
377.6ANGPT2, ANGPT1, VEGFA, MTOR, FGF2, VWF

Compounds for genes affiliated with Pyogenic Granuloma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1fumagillin44 59 1111.9VEGFA, PLG, FGF2
2heparin44 28 11 2412.8VEGFA, PLG, SLC2A1, PECAM1
3mannitol44 1110.7ATF2, SLC2A1, TP73
4infliximab44 49 1111.6ANGPT2, TEK, VEGFA, FGF2
5hematoxylin449.6PLG, ACTC1, PECAM1, TP63
6cytochalasin d44 5910.5FGF2, VWF, PECAM1, SLC2A1, THBS1
7thalidomide44 49 59 1112.4VEGFA, FGF2, PLG, THBS1, STAT3
8steroid449.4MTOR, ANGPT2, ACTC1, PLG, ANGPT1
9fibrinogen449.4PECAM1, ANGPT1, ANGPT2, VWF, PLG, THBS1
10gefitinib44 49 1111.3PLG, VEGFA, FGF2, MTOR, STAT3
11arsenite44 2410.3MTOR, STAT3, VEGFA, PGR
12tetracycline44 1110.3DSPP, ANGPT1, VWF, THBS1, TP73, FGF2
13docetaxel44 49 59 1112.3PLG, PGR, VEGFA, MTOR, STAT3
14serine449.3THBS1, FGF2, SLC2A1, TEK, PECAM1, PLG
15imatinib44 49 1111.3VEGFA, ACTC1, MTOR, STAT3, TP73
16paclitaxel44 49 1111.3PGR, VEGFA, STAT3, PLG, ANGPT1, THBS1
17glucose449.2SLC2A1, ACTC1, THBS1, ANGPT2, ANGPT1, ATF2
18ribonucleic acid449.2ANGPT1, PGR, THBS1, SLC2A1, TEK, PECAM1
19wortmannin449.2STAT3, MTOR, ANGPT1, ANGPT2, THBS1, SLC2A1
20anisomycin44 1110.2MTOR, PECAM1, SLC2A1, ATF2, STAT3
21agar449.2SLC2A1, STAT3, FGF2, PECAM1, DSPP, PGR
22prostacyclin449.1VEGFA, ANGPT1, FGF2, VWF, PECAM1, THBS1
23tamoxifen44 49 28 1112.1THBS1, PGR, STAT3, MTOR, VEGFA, PLG
24progestin449.1ANGPT2, PGR, VEGFA, ANGPT1
25matrigel449.1STAT3, MTOR, ANGPT1, PLG, THBS1, ACTC1
26actinomycin d449.0FGF2, VEGFA, STAT3, SLC2A1, PECAM1, TP73
27dexamethasone44 49 28 1112.0ANGPT2, FGF2, SLC2A1, DSPP, VEGFA, MTOR
28rapamycin448.9SLC2A1, THBS1, ANGPT1, VEGFA, PECAM1, STAT3
295fluorouracil448.9STAT3, VEGFA, MTOR, PGR, THBS1, SLC2A1
30phosphatidylinositol448.8STAT3, SLC2A1, ANGPT1, TEK, ANGPT2, FGF2
31genistein44 28 59 2 11 2413.8MTOR, VEGFA, FGF2, STAT3, PGR, SLC2A1
32calcitriol44 59 11 2411.8FGF2, THBS1, DSPP, ATF2, SLC2A1
33ly294002448.7MTOR, STAT3, VEGFA, THBS1, ANGPT1, ANGPT2
34pd 98,059448.6ANGPT1, ATF2, SLC2A1, THBS1, MTOR, FGF2
35testosterone44 59 11 2411.6PGR, MTOR, VWF, THBS1, TP63, ACTC1
36nitric oxide44 11 2410.6VWF, ATF2, ANGPT2, PECAM1, TEK, THBS1
37threonine448.4ATF2, THBS1, PECAM1, TP73, MTOR, TEK
38cisplatin44 49 59 1111.4TP73, VEGFA, TP63, SLC2A1, ATF2, STAT3
39thymidine44 249.3EPHB4, ANGPT2, ANGPT1, PECAM1, FGF2, PLG
40oxygen44 249.3ANGPT2, THBS1, ATF2, SLC2A1, ACTC1, TEK
41h2o2448.3ATF2, STAT3, THBS1, VWF, DSPP, PECAM1
42alanine448.2DSPP, SLC2A1, STAT3, ATF2, FGF2, THBS1
43doxorubicin44 49 1110.0VEGFA, STAT3, TP63, TP73, THBS1, PGR
44cysteine447.9PLG, PGR, DSPP, VWF, ATF2, STAT3
45cyclosporin a44 28 599.7STAT3, ATF2, MTOR, ANGPT1, ANGPT2, FGF2
46calcium44 49 11 2410.6VWF, TP63, MTOR, ACTC1, PECAM1, ATF2
47paraffin447.0STAT3, TP73, DSPP, VEGFA, ANGPT1, ANGPT2
48retinoic acid44 247.9MTOR, EFNB2, PECAM1, ATF2, ANGPT2, FGF2
49vegf445.8STAT3, MTOR, ANGPT1, ANGPT2, EFNB2, EPHB4
50tyrosine445.4TP63, PECAM1, TEK, ACTC1, SLC2A1, TP73

GO Terms for genes affiliated with Pyogenic Granuloma

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16Gene Ontology
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Cellular components related to Pyogenic Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.9THBS1, VWF
2platelet alpha granule lumenGO:0310939.4VEGFA, VWF, PLG, THBS1
3cell surfaceGO:0099868.9VEGFA, EPHB4, PLG, THBS1, TEK
4extracellular spaceGO:0056158.8VEGFA, ANGPT1, ANGPT2, FGF2, PLG, THBS1
5extracellular regionGO:0055768.1FGF2, THBS1, PLG, VWF, TEK, VEGFA

Biological processes related to Pyogenic Granuloma according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1glomerulus vasculature developmentGO:07201210.4ANGPT2, ANGPT1
2negative regulation of fibrinolysisGO:05191810.2THBS1, PLG
3Tie signaling pathwayGO:04801410.2ANGPT1, TEK, ANGPT2
4negative regulation of angiogenesisGO:01652510.2TEK, THBS1, ANGPT2
5negative regulation of blood vessel endothelial cell migrationGO:04353710.2ANGPT2, THBS1, FGF2
6sprouting angiogenesisGO:00204010.2TEK, THBS1, ANGPT1
7positive regulation of intracellular protein kinase cascadeGO:01074010.1TEK, VEGFA
8mitotic G1 DNA damage checkpointGO:03157110.1TP63, TP73
9negative regulation of cell-substrate adhesionGO:01081210.1ANGPT2, PLG
10cell-substrate adhesionGO:03158910.1VWF, ANGPT1
11leukocyte migrationGO:05090010.0ANGPT1, ANGPT2, TEK, PECAM1
12positive regulation of peptidyl-serine phosphorylationGO:0331389.9VEGFA, ANGPT1, TEK
13negative regulation of endothelial cell apoptotic processGO:20003529.9TEK, ANGPT1
14positive regulation of protein phosphorylationGO:0019349.9MTOR, VEGFA
15positive chemotaxisGO:0509189.9ANGPT1, FGF2, VEGFA
16positive regulation of protein kinase B signaling cascadeGO:0518979.9ANGPT1, TEK, MTOR, THBS1
17activation of MAPK activityGO:0001879.8THBS1, TP73, FGF2
18positive regulation of endothelial cell migrationGO:0105959.8ANGPT1, THBS1, TEK, VEGFA
19positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7ANGPT1, VEGFA, MTOR
20positive regulation of ERK1 and ERK2 cascadeGO:0703749.7ANGPT1, TEK, FGF2
21positive regulation of blood vessel endothelial cell migrationGO:0435369.7VEGFA, FGF2, THBS1, ANGPT1
22positive regulation of endothelial cell proliferationGO:0019389.6FGF2, VEGFA, MTOR, TEK
23positive regulation of angiogenesisGO:0457669.6ANGPT2, VEGFA, FGF2, THBS1, TEK
24positive regulation of focal adhesion assemblyGO:0518949.6VEGFA, TEK
25outflow tract morphogenesisGO:0031519.6ATF2, THBS1, VEGFA
26angiogenesisGO:0015259.5VEGFA, ANGPT2, EPHB4, TEK
27platelet degranulationGO:0025769.5VWF, VEGFA, PLG, THBS1, PECAM1
28platelet activationGO:0301689.5THBS1, VEGFA, PLG, VWF, PECAM1
29negative regulation of apoptotic processGO:0430669.3VEGFA, THBS1, TEK, TP63, ANGPT1
30cell migration involved in sprouting angiogenesisGO:0020429.2EFNB2, VEGFA, EPHB4, FGF2
31signal transductionGO:0071659.1STAT3, MTOR, ANGPT2, PGR, FGF2, TEK
32nervous system developmentGO:0073999.1STAT3, EFNB2, FGF2, VEGFA
33cell adhesionGO:0071559.0EFNB2, PECAM1, EPHB4, THBS1, VWF
34blood coagulationGO:0075968.9TEK, PLG, VEGFA, ANGPT1, ANGPT2, VWF

Molecular functions related to Pyogenic Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.7TP73, TP63, SLC2A1, THBS1, VWF, VEGFA
2protein bindingGO:0055154.8TP73, STAT3, ATF2, MTOR, VEGFA, ANGPT2

Products for genes affiliated with Pyogenic Granuloma

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  • Antibodies
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Sources for Pyogenic Granuloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet