MCID: PYG006
MIFTS: 41

Pyogenic Granuloma malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

Aliases & Descriptions for Pyogenic Granuloma:

Name: Pyogenic Granuloma 50 69
Lobular Capillary Hemangioma 50
Granuloma Pyogenic 52

Classifications:



External Ids:

ICD10 33 L98.0

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 50 pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to clear cell acanthoma and hemangioma. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Propranolol and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
id Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 10.9
2 hemangioma 10.3
3 capillary hemangioma 10.3
4 sarcoma 10.2
5 mucoepidermoid esophageal carcinoma 10.1 ANGPT1 TEK
6 madras motor neuron disease 10.1 ANGPT1 ANGPT2
7 achromatopsia 10.1 ANGPT1 ANGPT2
8 degenerative disc disease 10.1 TEK VEGFA
9 hyperinsulinism 10.1 ANGPT2 VEGFA
10 submucous uterine fibroid 10.1 ANGPT2 VEGFA
11 vesiculobullous skin disease 10.1 TEK VEGFA
12 hypersensitivity syndrome, carbamazepine-induced 10.1 ANGPT2 VEGFA
13 retinal degeneration 10.1 TEK VEGFA
14 bipolar i disorder 10.1 ANGPT2 VEGFA
15 burns 10.1
16 adult infiltrating astrocytic neoplasm 10.1 ANGPT2 VEGFA
17 subdural empyema 10.0 TEK VEGFA
18 melanoma 10.0
19 oppositional defiant disorder 10.0 TEK VEGFA
20 pharc syndrome 10.0 MTOR VEGFA
21 fibroma 10.0
22 esophagitis 10.0
23 human granulocytic anaplasmosis 10.0 TEK VEGFA
24 pulmonary blastoma 10.0 ANGPT1 ANGPT2 TEK
25 multinodular goiter 10.0 MTOR VEGFA
26 ossifying fibroma 10.0
27 gingivitis 10.0
28 paronychia 10.0
29 hyperpituitarism 9.9 ACTC1 TEK
30 isolated anterior cervical hypertrichosis 9.9 ACTC1 VEGFA
31 epidermolysis bullosa simplex, sutosomal recessive 2 9.9 ANGPT2 VEGFA
32 human venous malformation 9.9 ANGPT2 VEGFA
33 gangliosidosis gm1 9.9 ACTC1 MTOR
34 pituitary infarct 9.9 ANGPT2 TEK VEGFA
35 vulvitis 9.9 ANGPT2 TEK VEGFA
36 citrullinemia, type ii, neonatal-onset 9.9 ANGPT2 TEK VEGFA
37 coronary stenosis 9.9 ACTC1 VEGFA
38 common variable immunodeficiency 9.9 ANGPT1 TEK VEGFA
39 hepatocellular carcinoma 9.9
40 endotheliitis 9.9
41 benign familial neonatal epilepsy 9.9 ACTC1 VEGFA
42 localized junctional epidermolysis bullosa, non-herlitz type 9.9 ANGPT1 ANGPT2 VEGFA
43 mucinous ovarian cystadenoma 9.9 ANGPT1 TEK VEGFA
44 glycerol kinase deficiency, adult form 9.9 ACTC1 VEGFA
45 mental retardation, autosomal recessive 27 9.9 ANGPT1 ANGPT2 VEGFA
46 sarcomatoid renal cell carcinoma 9.9 MTOR VEGFA
47 kaposi sarcoma 9.8
48 lymphoma 9.8
49 bacillary angiomatosis 9.8
50 basal cell carcinoma 9.8

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ACTC1 ANGPT1 ANGPT2 MTOR TEK VEGFA
2 homeostasis/metabolism MP:0005376 9.63 ACTC1 ANGPT1 ANGPT2 MTOR TEK VEGFA
3 mortality/aging MP:0010768 9.43 ACTC1 ANGPT1 ANGPT2 MTOR TEK VEGFA
4 muscle MP:0005369 9.02 ANGPT1 MTOR TEK VEGFA ACTC1

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Adrenergic Agents
3 Adrenergic Antagonists
4 Neurotransmitter Agents
5 Adrenergic beta-Antagonists

Interventional clinical trials:


id Name Status NCT ID Phase
1 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
2 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
3 Maximizing Trichiasis Surgery Success Recruiting NCT03100747
4 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Not yet recruiting NCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

39
Skin, Tongue, Bone, Colon, Endothelial, Bone Marrow, Testes

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 581)
id Title Authors Year
1
Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis. ( 27982195 )
2016
2
Capillary hemangioma or pyogenic granuloma. ( 27041829 )
2016
3
The Histopathological Spectrum of Pyogenic Granuloma: A Case Series. ( 27382492 )
2016
4
Angioleiomyoma of Gingiva Masquerading as Pyogenic Granuloma. ( 27504561 )
2016
5
Timolol for the treatment of pyogenic granuloma (PG) in children. ( 27543231 )
2016
6
Pyogenic granuloma underlying cutaneous horn in a young boy. ( 27057494 )
2016
7
Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report. ( 26889266 )
2016
8
Periungual Pyogenic Granuloma: The Importance of the Medical History. ( 27386461 )
2016
9
Oral Pathology Quiz #90. Case Number 4. Pyogenic granuloma. ( 27159943 )
2016
10
Pyogenic granuloma of the duodenum. ( 26948163 )
2016
11
Recurrent Pyogenic Granuloma Around Dental Implants: A Rare Case Report. ( 27333016 )
2016
12
Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser. ( 27874157 )
2016
13
BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. ( 26802240 )
2016
14
Oral pyogenic granuloma gravidarum: A case report describing a large bleeding lingual lesion. ( 28019137 )
2016
15
Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision. ( 27258719 )
2016
16
Color-Doppler US features of a pyogenic granuloma of the upper dorsum tongue. ( 26941877 )
2016
17
Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia. ( 27403353 )
2016
18
Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. ( 27210602 )
2016
19
Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature. ( 27192522 )
2016
20
Pyogenic granuloma of the jejunum; diagnosis and treatment with double-balloon enteroscopy: A case report. ( 27161794 )
2016
21
Is timolol an effective treatment for pyogenic granuloma? ( 26872444 )
2016
22
Treatment of pediatric pyogenic granuloma in a functionally and cosmetically sensitive area with the 1064nm ND:Yag laser. ( 27617472 )
2016
23
Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. ( 27990392 )
2016
24
Management of a Recurrent Pyogenic Granuloma of the Hard Palate with Diode Laser: A Case Report. ( 27330700 )
2016
25
Oral Pyogenic Granuloma After Bone Marrow Transplant in the Pediatric/Adolescent Population: Report of 5 Cases. ( 27271813 )
2016
26
Agminated eruptive pyogenic granuloma on chin following redundant needle injections. ( 26813235 )
2016
27
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. ( 27116335 )
2016
28
Pyogenic Granuloma in a Patient on Gefitinib. ( 27865223 )
2016
29
Demographics and etiologic factors of nasal pyogenic granuloma. ( 27122134 )
2016
30
CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature. ( 27420917 )
2016
31
Pyogenic Granuloma on the Upper Lip: A Rare Location. ( 27997445 )
2016
32
Pyogenic Granuloma-Like Kaposi's Sarcoma. ( 27072065 )
2016
33
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
34
Extra-Gingival Pyogenic Granuloma Displacing Teeth. ( 27755424 )
2016
35
Pyogenic granuloma association with isotretinoin treatment for acne. ( 27885661 )
2016
36
Squamous cell carcinoma of the nail fold masquerading as pyogenic granuloma. ( 27241502 )
2016
37
Expression of embryonic stem cell markers in pyogenic granuloma. ( 27509392 )
2016
38
Pyogenic granuloma possibly associated with capecitabine therapy. ( 27864844 )
2016
39
A Rare Case of Pyogenic Granuloma with a Natal Tooth. ( 27891487 )
2016
40
Pyogenic granuloma-like basal cell carcinoma on the abdomen: A deceptive presentation. ( 27730056 )
2016
41
Chronic red eye due to amelanotic conjuctival melanoma masquerading as pyogenic granuloma. More than meets the eye. ( 25619360 )
2015
42
Multiple Pyogenic Granulomas After Burns: Response to Conservative Treatment in Five Children. ( 25895011 )
2015
43
Unusual case of pyogenic granuloma-like Kaposi's sarcoma on the sole. ( 25683322 )
2015
44
Congenital and Disseminated Pyogenic Granuloma-like Vascular Lesions. ( 25720992 )
2015
45
Oral and Maxillofacial Pathology. Case of the Month. Diagnosis. Pregnancy tumor (Pyogenic granuloma). ( 26863731 )
2015
46
The Combined use of Diode LASER & Conscious Sedation in the Excision of Pyogenic Granuloma in A Nine-Year-Old Patient. ( 26816994 )
2015
47
An intraoral epitheloid hemangioendothelioma masquerading clinically as pyogenic granuloma. ( 25821301 )
2015
48
Pyogenic granuloma in differential iron deficiency diagnosis. ( 25698283 )
2015
49
Pyogenic granuloma in the small intestine: a rare cause of obscure gastrointestinal bleeding. ( 25857476 )
2015
50
Red, exophytic nodule of the plantar foot an unusual presentation of a pyogenic granuloma. ( 25815662 )
2015

Variations for Pyogenic Granuloma

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ANGPT1 ANGPT2 MTOR TEK VEGFA
2
Show member pathways
13.19 ANGPT1 ANGPT2 MTOR TEK VEGFA
3
Show member pathways
13.07 ANGPT1 ANGPT2 MTOR TEK VEGFA
4
Show member pathways
12.99 ANGPT1 ANGPT2 MTOR TEK
5
Show member pathways
12.9 ANGPT1 ANGPT2 TEK VEGFA
6
Show member pathways
12.31 ANGPT1 ANGPT2 TEK VEGFA
7
Show member pathways
12.2 ANGPT1 ANGPT2 TEK
8 11.89 ANGPT1 ANGPT2 MTOR TEK VEGFA
9
Show member pathways
11.83 ANGPT1 ANGPT2 TEK
10 11.5 ANGPT2 TEK
11 11.45 ANGPT1 TEK VEGFA
12 11.23 MTOR TEK
13 11.05 ANGPT1 TEK
14 11.02 ANGPT1 ANGPT2 MTOR TEK VEGFA
15 11 ANGPT1 ANGPT2 VEGFA
16 10.71 ANGPT1 TEK VEGFA

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 ACTC1 ANGPT1 ANGPT2 VEGFA
2 actin filament GO:0005884 8.96 ACTC1 TEK
3 microvillus GO:0005902 8.62 ANGPT1 TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.79 ACTC1 MTOR VEGFA
2 negative regulation of apoptotic process GO:0043066 9.76 ACTC1 ANGPT1 TEK VEGFA
3 leukocyte migration GO:0050900 9.73 ANGPT1 ANGPT2 TEK
4 response to hypoxia GO:0001666 9.69 ANGPT2 TEK VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.67 MTOR TEK VEGFA
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.64 ANGPT1 VEGFA
7 negative regulation of protein phosphorylation GO:0001933 9.64 ANGPT1 MTOR
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 ANGPT1 TEK
9 negative regulation of angiogenesis GO:0016525 9.63 ANGPT2 TEK
10 heart morphogenesis GO:0003007 9.62 MTOR VEGFA
11 positive regulation of cell adhesion GO:0045785 9.62 ANGPT1 VEGFA
12 cardiac muscle contraction GO:0060048 9.61 ACTC1 MTOR
13 positive regulation of angiogenesis GO:0045766 9.61 ANGPT2 TEK VEGFA
14 positive chemotaxis GO:0050918 9.6 ANGPT1 VEGFA
15 germ cell development GO:0007281 9.59 ANGPT2 MTOR
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ANGPT1 TEK
17 maternal process involved in female pregnancy GO:0060135 9.58 ANGPT2 MTOR
18 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 ANGPT1 MTOR VEGFA
19 sprouting angiogenesis GO:0002040 9.57 ANGPT1 TEK
20 positive regulation of focal adhesion assembly GO:0051894 9.55 TEK VEGFA
21 positive regulation of receptor internalization GO:0002092 9.54 ANGPT1 VEGFA
22 positive regulation of protein kinase B signaling GO:0051897 9.54 ANGPT1 MTOR TEK
23 positive regulation of blood vessel endothelial cell migration GO:0043536 9.52 ANGPT1 VEGFA
24 positive regulation of endothelial cell proliferation GO:0001938 9.5 MTOR TEK VEGFA
25 growth GO:0040007 9.48 MTOR VEGFA
26 angiogenesis GO:0001525 9.46 ANGPT1 ANGPT2 TEK VEGFA
27 positive regulation of endothelial cell migration GO:0010595 9.43 ANGPT1 TEK VEGFA
28 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
29 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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