MCID: PYG006
MIFTS: 41

Pyogenic Granuloma malady

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotype Drugs

Aliases & Classifications for Pyogenic Granuloma

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Aliases & Descriptions for Pyogenic Granuloma:

Name: Pyogenic Granuloma 48 68
Lobular Capillary Hemangioma 48
 
Granuloma Pyogenic 50

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 30


External Ids:

ICD1030 L98.0

Summaries for Pyogenic Granuloma

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NIH Rare Diseases:48 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery, freezing, or lasers. Last updated: 11/13/2012

MalaCards based summary: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to rheumatoid arthritis and clear cell acanthoma, and has symptoms including leser-trélat sign An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways are Angiogenesis (CST) and G-protein signaling_H-RAS regulation pathway. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are cardiovascular system and muscle.

Wikipedia:71 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

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Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.3ANGPT1, TEK, VEGFA
2clear cell acanthoma10.9
3hemangioma10.3
4capillary hemangioma10.3
5bile duct mucoepidermoid carcinoma10.2ANGPT1, TEK
6sarcoma10.2
7achromatopsia10.1ANGPT1, ANGPT2
8epidermolysis bullosa10.1TEK, VEGFA
9cyclothymic disorder10.1TEK, VEGFA
10hole retinal cyst10.1ANGPT2, VEGFA
11burns10.1
12epidural abscess10.1TEK, VEGFA
13gasserian ganglion meningioma10.0ANGPT2, VEGFA
14fibroma10.0
15esophagitis10.0
16renal fibrosis10.0TEK, VEGFA
17opportunistic mycosis10.0ANGPT2, VEGFA
18paronychia10.0
19ossifying fibroma10.0
20gingivitis10.0
21renal tubular transport disease9.9TEK, VEGFA
22neuropathy, hereditary sensory and autonomic, type vi9.9ANGPT2, VEGFA
23hematopoietic stem cell transplantation9.9TEK, VEGFA
24hepatocellular carcinoma9.9
25endotheliitis9.9
26frontal sinus squamous cell carcinoma9.9ACTC1, TEK
27kaposi sarcoma9.9
28acne9.9
29lymphoma9.9
30bacillary angiomatosis9.9
31basal cell carcinoma9.9
32amelanotic melanoma9.9
33weber syndrome9.9
34angiomatosis9.9
35striatonigral degeneration9.8ANGPT1, ANGPT2, TEK
36holoprosencephaly9.8ANGPT2, VEGFA
37breast cancer9.8
38anaplastic large cell lymphoma9.8
39leukemia9.8
40angiosarcoma9.8
41vaginitis9.8
42laryngitis9.8
43epulis9.8
44periodontitis9.8
45gigantism9.8
46hemangioendothelioma9.8
47iridogoniodysgenesis and skeletal anomalies9.8ACTC1, VEGFA
48vertebral artery occlusion9.7ANGPT2, TEK, VEGFA
49apocrine adenoma9.7ANGPT2, TEK, VEGFA
50citrullinemia, adult-onset type ii9.7ANGPT2, TEK, VEGFA

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to pyogenic granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

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UMLS symptoms related to Pyogenic Granuloma:


leser-trélat sign

MGI Mouse Phenotypes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5ACTC1, ANGPT1, ANGPT2, TEK, VEGFA
2MP:00053698.4ACTC1, ANGPT1, MTOR, TEK, VEGFA
3MP:00053918.1ANGPT1, ANGPT2, TEK, VEGFA
4MP:00053767.9ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA
5MP:00107687.9ACTC1, ANGPT1, ANGPT2, MTOR, TEK, VEGFA

Drugs & Therapeutics for Pyogenic Granuloma

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Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Propranololapproved, investigational216525-66-64946
Synonyms:
(+-)-Propranolol
(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol
(R)-(+)-propranolol
(S)-(-)-PROPRANOLOL
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane
1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
13013-17-7
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
4199-09-1
4199-10-4
525-66-6
AB00053537
AC1L1JA4
AC1Q1QBV
AC1Q1QC0
AKOS000588816
AY 64043
AY-20694
Anaprilin
Anapriline
Angilol
Apsolol
Avlocardyl
BPBio1_001040
BRD-A10070317-003-06-9
BSPBio_000944
BSPBio_002682
Bedranol
Beprane
Berkolol
Beta Neg
Beta-Neg
Beta-Propranolol
Beta-Tablinen
Beta-Timelets
Betachron
Betadren
Betalong
Bio-0732
Bio1_000367
Bio1_000856
Bio1_001345
C07407
C16H21NO2
CBDivE_006180
CCRIS 3082
CHEBI:8499
CHEMBL27
CID4946
Cardinol
Caridolol
Corpendol
D,L-Propranolol
D08443
DB00571
DL-Propranolol hydrochloride
Deralin
DivK1c_000023
Dl-Propranolol Hydrochloride
Dociton
Duranol
EINECS 208-378-0
EINECS 235-867-6
Efektolol
Elbrol
Etalong
Euprovasin
Frekven
HMS2090L21
Herzbase
ICI 45520
IDI1_000023
INDERIDE-40/25
INDERIDE-80/25
Ikopal
Inderal
Inderal La
Inderal hydrochloride
Inderalici
Inderex
Inderide
Inderol
Indobloc
InnoPranXL
 
Innopran XL
Intermigran
KBio1_000023
KBio2_002515
KBio2_005083
KBio2_007651
KBio3_001766
KBio3_001902
KBio3_002993
KBioGR_001347
KBioGR_001684
KBioGR_002515
KBioSS_002523
Kemi
Kemi S
L000679
LS-122410
LS-184129
Lopac0_000896
Migrastat
MolPort-001-794-623
NCGC00015798-07
NCGC00024690-02
NCGC00024690-03
NINDS_000023
NSC91523
Naprilin
Obsidan
Obzidan
Oposim
Oprea1_304193
PDSP1_000767
PDSP1_001607
PDSP1_001608
PDSP2_000755
PDSP2_001591
PDSP2_001592
Prano-Puren
Pranolol
Prestwick0_000952
Prestwick1_000952
Prestwick2_000952
Prestwick3_000952
Pronovan
Propanalol
Propanix
Propanolol
Propanolol [INN-Spanish]
Prophylux
Propranalol
Propranolol
Propranolol (INN)
Propranolol (TN)
Propranolol Hcl
Propranolol Hcl Intensol
Propranolol Hydrochloride
Propranolol [INN:BAN]
Propranololo
Propranololo [DCIT]
Propranololum
Propranololum [INN-Latin]
Propranur
Proprasylyt
Pylapron
R,S-Propranolol Hydrochloride
Racemic propranolol
Rapynogen
Reducor
Reducor Line
Reducor line
SPBio_001361
SPBio_001658
SPBio_003093
STK735510
Sagittol
Sawatal
Servanolol
Sloprolol
Spectrum2_001301
Spectrum2_001699
Spectrum3_000883
Spectrum3_001071
Spectrum4_000974
Spectrum4_001222
Spectrum5_000751
Sumial
Tesnol
UNII-9Y8NXQ24VQ
b-Propranolol
beta-Propranolol
cMAP_000071
etalong
propranolol
propranololo
β-Propranolol
2Neurotransmitter Agents17734
3Adrenergic beta-Antagonists1154
4Adrenergic Antagonists1535
5Adrenergic Agents5140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Modified Instrumentation for Surgery to Correct TrichiasisUnknown statusNCT00886015Phase 3
2Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric TumorsCompletedNCT02334930
3Clinical Efficacy of Nail Brace for Treatment of Ingrown ToenailsNot yet recruitingNCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

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Anatomical Context for Pyogenic Granuloma

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MalaCards organs/tissues related to Pyogenic Granuloma:

36
Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Testes

Publications for Pyogenic Granuloma

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Articles related to Pyogenic Granuloma:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. (27116335)
2016
2
CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature. (27420917)
2016
3
Capillary hemangioma or pyogenic granuloma. (27041829)
2016
4
Demographics and etiologic factors of nasal pyogenic granuloma. (27122134)
2016
5
Oral pyogenic granuloma gravidarum: A case report describing a large bleeding lingual lesion. (28019137)
2016
6
Angioleiomyoma of Gingiva Masquerading as Pyogenic Granuloma. (27504561)
2016
7
Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. (27210602)
2016
8
Extra-Gingival Pyogenic Granuloma Displacing Teeth. (27755424)
2016
9
A Rare Case of Pyogenic Granuloma with a Natal Tooth. (27891487)
2016
10
Agminated eruptive pyogenic granuloma on chin following redundant needle injections. (26813235)
2016
11
Pyogenic granuloma underlying cutaneous horn in a young boy. (27057494)
2016
12
Oral Pathology Quiz #90. Case Number 4. Pyogenic granuloma. (27159943)
2016
13
The Histopathological Spectrum of Pyogenic Granuloma: A Case Series. (27382492)
2016
14
Pyogenic granuloma possibly associated with capecitabine therapy. (27864844)
2016
15
Is timolol an effective treatment for pyogenic granuloma? (26872444)
2016
16
Management of a Recurrent Pyogenic Granuloma of the Hard Palate with Diode Laser: A Case Report. (27330700)
2016
17
Pyogenic Granuloma in a Patient on Gefitinib. (27865223)
2016
18
Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia. (27403353)
2016
19
Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser. (27874157)
2016
20
Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. (27990392)
2016
21
Pyogenic Granuloma on the Upper Lip: A Rare Location. (27997445)
2016
22
Pyogenic Granuloma-Like Kaposi's Sarcoma. (27072065)
2016
23
Color-Doppler US features of a pyogenic granuloma of the upper dorsum tongue. (26941877)
2016
24
Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature. (27192522)
2016
25
Pyogenic granuloma of the jejunum; diagnosis and treatment with double-balloon enteroscopy: A case report. (27161794)
2016
26
Squamous cell carcinoma of the nail fold masquerading as pyogenic granuloma. (27241502)
2016
27
Treatment of pediatric pyogenic granuloma in a functionally and cosmetically sensitive area with the 1064nm ND:Yag laser. (27617472)
2016
28
Expression of embryonic stem cell markers in pyogenic granuloma. (27509392)
2016
29
Timolol for the treatment of pyogenic granuloma (PG) in children. (27543231)
2016
30
Periungual Pyogenic Granuloma: The Importance of the Medical History. (27386461)
2016
31
Pyogenic granuloma association with isotretinoin treatment for acne. (27885661)
2016
32
Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision. (27258719)
2016
33
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. (26955141)
2016
34
Recurrent Pyogenic Granuloma Around Dental Implants: A Rare Case Report. (27333016)
2016
35
BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. (26802240)
2016
36
Pyogenic granuloma of the duodenum. (26948163)
2016
37
Oral Pyogenic Granuloma After Bone Marrow Transplant in the Pediatric/Adolescent Population: Report of 5 Cases. (27271813)
2016
38
Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report. (26889266)
2016
39
Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis. (27982195)
2016
40
Pyogenic granuloma-like basal cell carcinoma on the abdomen: A deceptive presentation. (27730056)
2016
41
Chronic red eye due to amelanotic conjuctival melanoma masquerading as pyogenic granuloma. More than meets the eye. (25619360)
2015
42
Pyogenic granuloma in the small intestine: a rare cause of obscure gastrointestinal bleeding. (25857476)
2015
43
Multiple Pyogenic Granulomas After Burns: Response to Conservative Treatment in Five Children. (25895011)
2015
44
Palisaded Encapsulated Neuroma of the Tongue Clinically Mimicking a Pyogenic Granuloma: A Case Report and Review of Literature. (26877744)
2015
45
Pyogenic granuloma of the small bowel treated by double-balloon enteroscopy. (25660981)
2015
46
Expedited removal of pyogenic granuloma by diode laser in a pediatric patient. (25699167)
2015
47
Giant palatal pyogenic granuloma. (25651348)
2015
48
Oral and Maxillofacial Pathology. Case of the Month. Diagnosis. Pregnancy tumor (Pyogenic granuloma). (26863731)
2015
49
Red, exophytic nodule of the plantar foot an unusual presentation of a pyogenic granuloma. (25815662)
2015
50
Immunohistochemical Evaluation of Angiogenesis Related Markers in Pyogenic Granuloma of Gingiva. (26625754)
2015

Variations for Pyogenic Granuloma

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Expression for genes affiliated with Pyogenic Granuloma

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Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

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Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
1
Angiogenesis (CST)3
Show member pathways
9.5ANGPT2, TEK
2
G-protein signaling_H-RAS regulation pathway65
9.4ANGPT1, TEK
3
Cell surface interactions at the vascular wall60
Show member pathways
8.9ANGPT1, ANGPT2, TEK
4
Immune response IL-23 signaling pathway65
Show member pathways
8.9ANGPT1, ANGPT2, TEK
5
Immune response IFN gamma signaling pathway65
Show member pathways
8.8ANGPT1, ANGPT2, MTOR
6
Rheumatoid arthritis34
8.6ANGPT1, TEK, VEGFA
7
Angiogenesis (WikiPathways)42
Show member pathways
8.6ANGPT1, TEK, VEGFA
8
Akt Signaling58
Show member pathways
8.4ANGPT1, ANGPT2, MTOR, TEK
9
Ras signaling pathway34
Show member pathways
8.1ANGPT1, ANGPT2, TEK, VEGFA
10
ERK Signaling58
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
11
TGF-Beta Pathway58
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
12
PI3K-Akt signaling pathway34
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
13
HIF-1 signaling pathway34
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA
14
PEDF Induced Signaling58
Show member pathways
7.6ANGPT1, ANGPT2, MTOR, TEK, VEGFA

GO Terms for genes affiliated with Pyogenic Granuloma

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Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin filamentGO:000588410.4ACTC1, TEK
2microvillusGO:00059029.4ANGPT1, TEK
3extracellular regionGO:00055768.8ANGPT1, ANGPT2, TEK, VEGFA
4extracellular spaceGO:00056158.5ACTC1, ANGPT1, ANGPT2, VEGFA

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1animal organ regenerationGO:003110010.3ANGPT2, TEK
2negative regulation of angiogenesisGO:001652510.3ANGPT2, TEK
3cardiac muscle contractionGO:006004810.2ACTC1, MTOR
4germ cell developmentGO:000728110.2ANGPT2, MTOR
5maternal process involved in female pregnancyGO:006013510.2ANGPT2, MTOR
6negative regulation of endothelial cell apoptotic processGO:200035210.2ANGPT1, TEK
7positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.1ANGPT1, TEK
8glomerulus vasculature developmentGO:007201210.1ANGPT1, ANGPT2
9negative regulation of protein phosphorylationGO:000193310.1ANGPT1, MTOR
10sprouting angiogenesisGO:000204010.0ANGPT1, TEK
11positive regulation of focal adhesion assemblyGO:005189410.0TEK, VEGFA
12growthGO:00400079.9MTOR, VEGFA
13heart morphogenesisGO:00030079.9MTOR, VEGFA
14positive chemotaxisGO:00509189.8ANGPT1, VEGFA
15positive regulation of blood vessel endothelial cell migrationGO:00435369.7ANGPT1, VEGFA
16positive regulation of cell adhesionGO:00457859.7ANGPT1, VEGFA
17positive regulation of peptidyl-serine phosphorylationGO:00331389.7ANGPT1, VEGFA
18leukocyte migrationGO:00509009.7ANGPT1, ANGPT2, TEK
19positive regulation of receptor internalizationGO:00020929.7ANGPT1, VEGFA
20positive regulation of protein kinase B signalingGO:00518979.6ANGPT1, MTOR, TEK
21Tie signaling pathwayGO:00480149.5ANGPT1, ANGPT2, TEK
22transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.4ANGPT1, TEK
23positive regulation of angiogenesisGO:00457669.4ANGPT2, TEK, VEGFA
24positive regulation of endothelial cell proliferationGO:00019389.4MTOR, TEK, VEGFA
25positive regulation of gene expressionGO:00106289.4ACTC1, MTOR, VEGFA
26positive regulation of protein phosphorylationGO:00019349.3MTOR, TEK, VEGFA
27positive regulation of endothelial cell migrationGO:00105959.3ANGPT1, TEK, VEGFA
28response to hypoxiaGO:00016669.3ANGPT2, TEK, VEGFA
29positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2ANGPT1, MTOR, VEGFA
30negative regulation of apoptotic processGO:00430668.9ACTC1, ANGPT1, TEK, VEGFA
31angiogenesisGO:00015258.9ANGPT1, ANGPT2, TEK, VEGFA

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.3ANGPT1, ANGPT2

Sources for Pyogenic Granuloma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z