MCID: PYG006
MIFTS: 42

Pyogenic Granuloma malady

Rare diseases, Skin diseases categories

Summaries for Pyogenic Granuloma

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NIH Rare Diseases:41 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. they typically occur on the hands, arms, or face. while the exact cause of pyogenic granulomas is unknown, they often appear following injury. pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. small pyogenic granulomas may go away on their own. larger lesions are treated with surgery, electrocautery, freezing, or lasers. last updated: 11/13/2012

MalaCards based summary: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to hemangioendothelioma and hemangioma. An important gene associated with Pyogenic Granuloma is ANGPT2 (angiopoietin 2), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and HIF-1 signaling pathway. The compounds glycosaminoglycan and infliximab have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:63 Pyogenic granuloma (also known as a \"Eruptive hemangioma\", \"Granulation tissue-type hemangioma\",... more...

Aliases & Classifications for Pyogenic Granuloma

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS, 25ICD10
See all sources

Pyogenic Granuloma, Aliases & Descriptions:

Name: Pyogenic Granuloma 41 60
Lobular Capillary Hemangioma 41
 
Granuloma Pyogenic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

ICD1025 L98.0

Related Diseases for Pyogenic Granuloma

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Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to pyogenic granuloma

Symptoms for Pyogenic Granuloma

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Drugs & Therapeutics for Pyogenic Granuloma

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Drug clinical trials:

Search ClinicalTrials for Pyogenic Granuloma

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

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Anatomical Context for Pyogenic Granuloma

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MalaCards organs/tissues related to Pyogenic Granuloma:

31
Skin, Tongue, Bone, Colon, Endothelial, Bone marrow, Small intestine, Testes, Trachea, Eye, Kidney, Adrenal gland, Breast, T cells

Animal Models for Pyogenic Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Pyogenic Granuloma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8PLG, ANGPT2, PECAM1
2MP:00053818.6PECAM1, ANGPT2, PLG
3MP:00053698.5ACTC1, PECAM1, TEK
4MP:00053848.0TEK, PECAM1, ACTC1, PLG
5MP:00053857.6PLG, ACTC1, ANGPT2, PECAM1, TEK
6MP:00053767.6TEK, PECAM1, ANGPT2, ACTC1, PLG

Publications for Pyogenic Granuloma

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Articles related to Pyogenic Granuloma:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Pyogenic granuloma in differential iron deficiency diagnosis. (25698283)
2015
2
Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)
2014
3
Pyogenic Granuloma: Surgical Treatment with Er:YAG Laser. (25653822)
2014
4
Pyogenic granuloma of the ileum diagnosed by double-balloon enteroscopy. (25224187)
2014
5
Pyogenic granuloma of the ileum depicted by small-bowel radiography, capsule endoscopy and double balloon endoscopy. (25553608)
2014
6
Nodular swelling on the lower lip; pyogenic granuloma. (25525490)
2014
7
Pyogenic granuloma of the gingiva: A misnomer? - A case report and review of literature. (24174735)
2013
8
Case of the month. Pyogenic granuloma. (23923461)
2013
9
Esophageal pyogenic granuloma: endosonographic findings and endoscopic treatments. (23423701)
2013
10
Oral capillary haemangioma mimicking pyogenic granuloma: a challenge for diagnosis and management. (23417375)
2013
11
Painless red lesion on the tongue. Pyogenic granuloma. (22414511)
2012
12
Exuberant pyogenic granuloma in extragingival site. (22936151)
2012
13
Photodynamic therapy with 5-aminolevulinic acid intralesional injection for pyogenic granuloma. (22250252)
2012
14
Giant cell tumor of tendon sheath mimicking pyogenic granuloma in the index finger pulp: a case report. (22351549)
2012
15
"Pyogenic granuloma - Hyperplastic lesion of the gingiva: case reports". (23091574)
2012
16
Concurrent occurrence of mucocele and pyogenic granuloma. (22028553)
2011
17
Pregnancy-associated pyogenic granuloma of the lip: a case report. (21970285)
2011
18
Clinical inquiries. What's the best treatment for pyogenic granuloma? (20074501)
2010
19
Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population. (20417014)
2010
20
Oral pathology quiz. Case number 2. Pyogenic granuloma. (20658767)
2010
21
Multiple pyogenic granuloma of the penis in a four-year-old child: a case report. (19918487)
2009
22
Congenital disseminated pyogenic granuloma. (19706097)
2009
23
Pyogenic granuloma: an unusual cause of massive gastrointestinal bleeding from the small bowel. (19373418)
2009
24
Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)
2009
25
Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. (18496485)
2008
26
Extragingival pyogenic granuloma: a case report. (19055747)
2008
27
Successful treatment of a therapy-resistant pyogenic granuloma with topical imiquimod 5% cream. (16766338)
2006
28
Comparison of cryotherapy and curettage for the treatment of pyogenic granuloma: a randomized trial. (16536810)
2006
29
Recurrent intraoral pyogenic granuloma with satellitosis treated with corticosteroids. (16390473)
2006
30
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
31
Is pyogenic granuloma associated with Bartonella infection? (16310070)
2005
32
Metastatic hepatocellular carcinoma of gingiva mimicking pyogenic granuloma. (12894096)
2003
33
Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. (14613084)
2003
34
Pediatric pyogenic granuloma of the glans penis. (12639669)
2003
35
Pyogenic granuloma-like lesions during capecitabine therapy. (12452889)
2002
36
Laryngeal pyogenic granulomas do not express oestrogen or progesterone receptors. (11667991)
2001
37
Onychomadesis and pyogenic granuloma following cast immobilization. (11176706)
2001
38
Pyogenic granuloma: who are you? (11495513)
2001
39
Pyogenic granuloma: a complication of transconjunctival incisions. (10744252)
2000
40
Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma. (10233658)
1999
41
Plaque radiation therapy for recurrent conjunctival pyogenic granuloma. (9565059)
1998
42
Pyogenic granuloma of the cornea. (9630306)
1998
43
Oral angiosarcoma misdiagnosed as a pyogenic granuloma. (9580135)
1998
44
The late development of oral pyogenic granuloma as a complication of pregnancy: a case report. (9051984)
1996
45
Oral pyogenic granuloma in pregnancy. (9764875)
1995
46
Intraoral pyogenic granuloma after allogeneic bone marrow transplant. Report of three cases. (7838468)
1994
47
Pyogenic granuloma following treatment of verruca vulgaris with cryotherapy and Duoplant. (2022132)
1991
48
The pyogenic granuloma. (6393917)
1984
49
A pyogenic granuloma and an irritation fibroma--case report. (297013)
1979
50
Pyogenic granuloma of the nasal cavity. (13902293)
1962

Variations for Pyogenic Granuloma

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Expression for genes affiliated with Pyogenic Granuloma

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Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for genes affiliated with Pyogenic Granuloma

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Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3PECAM1, PLG
29.2ANGPT2, TEK
39.2ANGPT2, TEK
4
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.7PLG, ANGPT2, TEK
58.6ANGPT2, PECAM1, TEK
6
Show member pathways
8.6TEK, PECAM1, ANGPT2
7
Show member pathways
8.1PLG, ANGPT2, PECAM1, TEK

Compounds for genes affiliated with Pyogenic Granuloma

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Compounds related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1glycosaminoglycan439.4PECAM1, ACTC1
2infliximab43 49 1211.4ANGPT2, TEK
3formaldehyde43 2410.3ACTC1, PECAM1
4steroid439.2ANGPT2, ACTC1, PLG
5hematoxylin439.1PLG, ACTC1, PECAM1
6fibrinogen439.1PLG, ANGPT2, PECAM1
7cyclosporin a43 28 5911.1PECAM1, ANGPT2, ACTC1
8p002439.1PECAM1, TEK
9estrogen438.9PECAM1, ANGPT2, ACTC1
10retinoic acid43 249.8ACTC1, ANGPT2, PECAM1
11glucose438.6PECAM1, ANGPT2, ACTC1, PLG
12atp43 289.6PLG, ANGPT2, PECAM1
13calcium43 49 24 1211.5PLG, ACTC1, ANGPT2, PECAM1
14ribonucleic acid438.4ACTC1, ANGPT2, PECAM1, TEK
15paraffin438.4TEK, PECAM1, ANGPT2, ACTC1
16thymidine43 249.4TEK, PECAM1, ANGPT2, PLG
17nitric oxide43 24 1210.3PLG, ANGPT2, PECAM1, TEK
18cysteine438.3TEK, PECAM1, ANGPT2, PLG
19serine438.3PLG, ANGPT2, PECAM1, TEK
20matrigel437.9PLG, ACTC1, ANGPT2, PECAM1, TEK
21vegf437.9TEK, PECAM1, ANGPT2, ACTC1, PLG
22oxygen43 248.9TEK, PECAM1, ANGPT2, ACTC1, PLG
23tyrosine437.8TEK, PECAM1, ANGPT2, ACTC1, PLG

GO Terms for genes affiliated with Pyogenic Granuloma

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Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.1ACTC1, PLG
2actin filamentGO:00058849.0ACTC1, TEK
3extracellular spaceGO:00056158.4PLG, ACTC1, ANGPT2, PECAM1
4plasma membraneGO:00058868.1PLG, ANGPT2, PECAM1, TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-substrate adhesionGO:00108129.7PLG, ANGPT2
2Tie signaling pathwayGO:00480149.5ANGPT2, TEK
3platelet degranulationGO:00025769.4PLG, PECAM1
4organ regenerationGO:00311009.4ANGPT2, TEK
5negative regulation of angiogenesisGO:00165259.3TEK, ANGPT2
6platelet activationGO:00301689.3PLG, PECAM1
7positive regulation of angiogenesisGO:00457669.3ANGPT2, TEK
8response to hypoxiaGO:00016669.1ANGPT2, TEK
9angiogenesisGO:00015258.9ANGPT2, TEK
10leukocyte migrationGO:00509008.8TEK, PECAM1, ANGPT2
11signal transductionGO:00071658.6TEK, PECAM1, ANGPT2
12blood coagulationGO:00075968.3PLG, ANGPT2, PECAM1, TEK

Products for genes affiliated with Pyogenic Granuloma

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Sources for Pyogenic Granuloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet