MCID: PYG006
MIFTS: 45

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 49 69
Lobular Capillary Hemangioma 49
Granuloma Pyogenic 51

Classifications:



External Ids:

ICD10 32 L98.0
UMLS 69 C0085653

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 49 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery, freezing, or lasers. Last updated: 11/13/2012

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to capillary hemangioma and angiosarcoma. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Propranolol and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 capillary hemangioma 30.7 TEK VEGFA
2 angiosarcoma 29.7 TEK VEGFA
3 intravascular papillary endothelial hyperplasia 29.2 ACTC1 VEGFA
4 mucositis 29.2 MTOR VEGFA
5 hemangioma 28.8 ACTC1 ANGPT1 ANGPT2 TEK VEGFA
6 rheumatoid arthritis 28.6 ANGPT1 TEK VEGFA
7 sarcoma 10.3
8 intramuscular hemangioma 10.2 ANGPT1 TEK
9 burns 10.2
10 melanoma 10.1
11 macrophage activation syndrome 10.1 ANGPT1 ANGPT2
12 adenosquamous pancreas carcinoma 10.1 ANGPT1 TEK
13 twin-to-twin transfusion syndrome 10.1 ANGPT1 ANGPT2
14 esophagitis 10.1
15 paronychia 10.1
16 gingivitis 10.1
17 ossifying fibroma 10.1
18 background diabetic retinopathy 10.0 ANGPT2 VEGFA
19 poems syndrome 10.0 ANGPT2 VEGFA
20 diabetic macular edema 10.0 TEK VEGFA
21 hepatocellular carcinoma 10.0
22 endotheliitis 10.0
23 macular holes 10.0 ANGPT2 VEGFA
24 corneal neovascularization 10.0 TEK VEGFA
25 sturge-weber syndrome 9.9
26 basal cell carcinoma 1 9.9
27 lymphoma 9.9
28 bacillary angiomatosis 9.9
29 basal cell carcinoma 9.9
30 hemangioendothelioma 9.9
31 kaposi sarcoma 9.9
32 weber syndrome 9.9
33 angiomatosis 9.9
34 amelanotic melanoma 9.9
35 microvascular complications of diabetes 1 9.9 ANGPT2 VEGFA
36 retinal vascular disease 9.9 ANGPT2 VEGFA
37 leukemia 9.9
38 vaginitis 9.9
39 breast cancer 9.9
40 iron metabolism disease 9.9
41 gigantism 9.9
42 epulis 9.9
43 renal cell carcinoma, nonpapillary 9.9
44 anaplastic large cell lymphoma 9.9
45 periodontitis 9.9
46 laryngitis 9.9
47 squamous cell carcinoma 9.9
48 placenta accreta 9.8 ANGPT1 ANGPT2 TEK
49 glomangioma 9.8 ACTC1 TEK
50 hereditary hemorrhagic telangiectasia 9.8 ANGPT2 VEGFA

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 MTOR TEK VEGFA ACTC1 ANGPT1 ANGPT2
2 homeostasis/metabolism MP:0005376 9.63 MTOR TEK VEGFA ACTC1 ANGPT1 ANGPT2
3 mortality/aging MP:0010768 9.43 ANGPT2 MTOR TEK VEGFA ACTC1 ANGPT1
4 muscle MP:0005369 9.02 MTOR TEK VEGFA ACTC1 ANGPT1

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Adrenergic Agents
3 Adrenergic Antagonists
4 Adrenergic beta-Antagonists
5 Neurotransmitter Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
2 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
3 Maximizing Trichiasis Surgery Success Recruiting NCT03100747
4 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Not yet recruiting NCT03008629

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

38
Skin, Tongue, Bone, Colon, Endothelial, Bone Marrow, Testes

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 615)
# Title Authors Year
1
Photodynamic therapy for periungual pyogenic granuloma-like during chemotherapy: our preliminary results. ( 29429004 )
2018
2
Topical Betaxolol for Treating Relapsing Paronychia with Pyogenic Granuloma-Like Lesions Induced by Epidermal Growth Factor Receptor Inhibitors. ( 29339238 )
2018
3
Extragingival Pregnancy Pyogenic Granuloma on the Lip. ( 29040143 )
2018
4
Periungual pyogenic granuloma-like lesions following plaster cast immobilization: a case managed with symptomatic therapy. ( 28985457 )
2018
5
Pyogenic granuloma-like Kaposi's sarcoma on the first toe. ( 29446122 )
2018
6
No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma. ( 29406329 )
2018
7
Pyogenic Granuloma of the Jejunum: an Unusual Cause of Anemia. ( 29374349 )
2018
8
Combination of ligation and timolol before surgical excision of pyogenic granuloma. ( 29307642 )
2018
9
Pyogenic granuloma: A tumor that mimics infection. ( 29369925 )
2018
10
Dermoscopy of Pyogenic Granuloma. ( 29204415 )
2017
11
An innovative and less invasive management of recurrent pyogenic granuloma in the esthetic zone: A case report with 18-month follow-up. ( 29440794 )
2017
12
Solitary nodule of angiolymphoid hyperplasia with eosinophilia of the back masquerading as pyogenic granuloma. ( 29181182 )
2017
13
Pyogenic Granuloma of the Penis: An Uncommon Lesion with Unusual Presentation. ( 28413384 )
2017
14
Cutaneous epithelioid hemangioendothelioma on the sole mimicking a pyogenic granuloma. ( 28664615 )
2017
15
Pyogenic Granuloma: A Retrospective Analysis of Cases Treated Over a 10-Year. ( 28913297 )
2017
16
Intravenous lobular capillary haemangioma (pyogenic granuloma): A case report and a review of imaging findings as reported in the literature. ( 28861947 )
2017
17
Image Gallery: Haemorrhagic shock due to a cutaneous pyogenic granuloma. ( 28833014 )
2017
18
Pyogenic granuloma-like lesion in children: Should we wait? ( 28615821 )
2017
19
Pyogenic Granuloma of the Vermilion of the Upper Lip. ( 29034867 )
2017
20
Lobular capillary hemangioma (pyogenic granuloma) of the oral cavity. ( 28719705 )
2017
21
A Research of Pyogenic Granuloma Genesis Factor With Immunohistochemical Analysis. ( 29019819 )
2017
22
Metastatic renal cell carcinoma presenting as multiple pyogenic granuloma-like nodules on the penis. ( 28971132 )
2017
23
Pyogenic Granuloma in an Unusual Site. ( 28491928 )
2017
24
Pyogenic Granuloma of the Esophagus. ( 28351792 )
2017
25
Pyogenic granuloma of the penis following chancre. ( 28850727 )
2017
26
Giant pyogenic granuloma of theA finger in an HIV-positive patient. ( 28556978 )
2017
27
Treatment of paediatric facial pyogenic granuloma with topical ingenol mebutate. ( 28691181 )
2017
28
Combined method to treat periungual pyogenic granuloma: Nail corner plasty, taping and topical bismuth subgallate. ( 28464348 )
2017
29
Malignant fibrous histiocytoma masquerading as pyogenic granuloma. ( 28388346 )
2017
30
Dermoscopy of pyogenic granuloma. ( 28819531 )
2017
31
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis. ( 28658902 )
2017
32
Pyogenic Granuloma of the Conjunctiva. ( 28445671 )
2017
33
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
34
Optic Disc Pyogenic Granuloma. ( 28868280 )
2017
35
Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options. ( 28785323 )
2017
36
Pyogenic Granuloma-Like Kaposi's Sarcoma. ( 27072065 )
2016
37
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
38
Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. ( 27210602 )
2016
39
Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. ( 27990392 )
2016
40
Pyogenic granuloma association with isotretinoin treatment for acne. ( 27885661 )
2016
41
Demographics and etiologic factors of nasal pyogenic granuloma. ( 27122134 )
2016
42
Pyogenic granuloma underlying cutaneous horn in a young boy. ( 27057494 )
2016
43
Squamous cell carcinoma of the nail fold masquerading as pyogenic granuloma. ( 27241502 )
2016
44
Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision. ( 27258719 )
2016
45
Oral Pathology Quiz #90. Case Number 4. Pyogenic granuloma. ( 27159943 )
2016
46
Pyogenic granuloma of the duodenum. ( 26948163 )
2016
47
Timolol for the treatment of pyogenic granuloma (PG) in children. ( 27543231 )
2016
48
Treatment of pediatric pyogenic granuloma in a functionally and cosmetically sensitive area with the 1064nm ND:Yag laser. ( 27617472 )
2016
49
BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. ( 26802240 )
2016
50
The Histopathological Spectrum of Pyogenic Granuloma: A Case Series. ( 27382492 )
2016

Variations for Pyogenic Granuloma

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ANGPT1 ANGPT2 MTOR TEK VEGFA
2
Show member pathways
13.21 ANGPT1 ANGPT2 MTOR TEK VEGFA
3
Show member pathways
13.09 ANGPT1 ANGPT2 MTOR TEK VEGFA
4
Show member pathways
13.01 ANGPT1 ANGPT2 MTOR TEK
5
Show member pathways
12.94 ANGPT1 ANGPT2 TEK VEGFA
6
Show member pathways
12.48 ANGPT1 ANGPT2 MTOR TEK VEGFA
7 12.37 ANGPT1 ANGPT2 TEK VEGFA
8
Show member pathways
12.31 ANGPT1 ANGPT2 TEK VEGFA
9
Show member pathways
12.23 ANGPT1 ANGPT2 TEK
10
Show member pathways
12.2 ANGPT2 MTOR VEGFA
11
Show member pathways
11.86 ANGPT1 ANGPT2 TEK
12 11.52 ANGPT2 TEK
13 11.45 ANGPT1 TEK VEGFA
14 11.27 MTOR TEK
15 11.06 ANGPT1 TEK
16 11.02 ANGPT1 ANGPT2 MTOR TEK VEGFA
17 10.9 ANGPT1 ANGPT2 VEGFA
18 10.66 ANGPT1 ANGPT2 TEK
19 10.51 ANGPT1 TEK VEGFA

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.96 ACTC1 TEK
2 microvillus GO:0005902 8.62 ANGPT1 TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 ACTC1 MTOR VEGFA
2 leukocyte migration GO:0050900 9.71 ANGPT1 ANGPT2 TEK
3 negative regulation of apoptotic process GO:0043066 9.71 ACTC1 ANGPT1 TEK VEGFA
4 response to hypoxia GO:0001666 9.69 ANGPT2 TEK VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.67 MTOR TEK VEGFA
6 positive regulation of protein kinase B signaling GO:0051897 9.65 ANGPT1 MTOR TEK
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.64 ANGPT1 VEGFA
8 negative regulation of protein phosphorylation GO:0001933 9.63 ANGPT1 MTOR
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 ANGPT1 TEK
10 heart morphogenesis GO:0003007 9.62 MTOR VEGFA
11 positive regulation of cell adhesion GO:0045785 9.61 ANGPT1 VEGFA
12 cardiac muscle contraction GO:0060048 9.61 ACTC1 MTOR
13 positive regulation of angiogenesis GO:0045766 9.61 ANGPT2 TEK VEGFA
14 positive chemotaxis GO:0050918 9.6 ANGPT1 VEGFA
15 germ cell development GO:0007281 9.59 ANGPT2 MTOR
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 ANGPT1 VEGFA
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ANGPT1 TEK
18 sprouting angiogenesis GO:0002040 9.57 ANGPT1 TEK
19 maternal process involved in female pregnancy GO:0060135 9.56 ANGPT2 MTOR
20 positive regulation of focal adhesion assembly GO:0051894 9.55 TEK VEGFA
21 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 ANGPT1 MTOR VEGFA
22 positive regulation of receptor internalization GO:0002092 9.52 ANGPT1 VEGFA
23 positive regulation of endothelial cell proliferation GO:0001938 9.5 MTOR TEK VEGFA
24 growth GO:0040007 9.46 MTOR VEGFA
25 angiogenesis GO:0001525 9.46 ANGPT1 ANGPT2 TEK VEGFA
26 positive regulation of endothelial cell migration GO:0010595 9.43 ANGPT1 TEK VEGFA
27 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
28 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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