Aliases & Classifications for Q Fever

MalaCards integrated aliases for Q Fever:

Name: Q Fever 12 72 49 55 3 41 14 69
Infection Due to Coxiella Burnetii 12 55
Quadrilateral Fever 55 69
Query Fever 49 55
Coxiella Burnetii Fever 49
Pneumonia in Q Fever 69
Q Fever Pneumonia 49
Nine Mile Fever 55
Coxiellosis 55

Characteristics:

Orphanet epidemiological data:

55
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11100
ICD10 32 A78
ICD9CM 34 083.0
MeSH 41 D011778
NCIt 46 C34970
Orphanet 55 ORPHA781
MESH via Orphanet 42 D011778
UMLS via Orphanet 70 C0034362 C2973787
ICD10 via Orphanet 33 A78

Summaries for Q Fever

NIH Rare Diseases : 49 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and waste products of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection. In less than 5% of cases the affected people with acute Q fever infection develop a chronic Q fever. Treatment of the acute form is made with antibiotics. The chronic form's treatment depends on the symptoms. Last updated: 7/8/2015

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and spotted fever, and has symptoms including fever, headache and cough. An important gene associated with Q Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Doxycycline and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and monocytes, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia : 72 Q... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.4 IL10 TLR2 TNF
2 spotted fever 30.7 IFNG IL10 TNF
3 osteomyelitis 30.3 IFNG IL10 IL1B TNF
4 uveitis 30.3 IFNG IL10 TNF
5 ross river fever 30.3 CD40LG IL10
6 miller fisher syndrome 30.2 CD40LG TNF
7 neuritis 30.1 IFNG IL1B TNF
8 coccidioidomycosis 30.1 CD40LG TLR4
9 cat-scratch disease 30.1 CD40LG IFNG
10 prostatitis 30.0 IL10 IL1B TNF
11 plasmodium falciparum malaria 30.0 IFNG IL10 TNF
12 chronic fatigue syndrome 30.0 IL10 IL1B TNF
13 prosthetic joint infection 29.9 IL1B TLR2 TLR4
14 brucellosis 29.9 CD40LG IFNG IL10 TLR4 TNF
15 leptospirosis 29.9 CD40LG IL10 IL1B TLR2 TNF
16 arthritis 29.8 IFNG IL10 IL1B TNF
17 anterior uveitis 29.8 TLR4 TNF
18 campylobacteriosis 29.7 IFNG IL1B TLR4
19 pneumonia 29.7 CD40LG IL10 IL1B TLR2 TLR4 TNF
20 glomerulonephritis 29.6 CD40LG CD79A IL1B
21 peritonitis 29.6 IFNG IL10 IL1B TLR2 TNF
22 pertussis 29.4 IL10 IL1B TLR4 TNF
23 scrub typhus 29.4 CD40LG IL10 IL1B TLR2 TLR4 TNF
24 hepatitis b 29.4 IFNG TLR2 TLR4 TNF
25 trench fever 29.4 CD40LG TLR2 TLR4 TNF
26 crohn's disease 29.1 IFNG IL10 IL1B TLR4 TNF
27 lyme disease 28.9 CD40LG IL1B TLR1 TLR2 TNF
28 autoimmune disease 28.8 CD40LG CD79A IFNG IL10 IL1B TNF
29 mycobacterium tuberculosis 1 28.5 IFNG IL10 TLR1 TLR2 TLR4 TNF
30 systemic lupus erythematosus 28.4 CD40LG CD79A IFNG IL10 IL1B TLR4
31 malaria 28.3 CD40LG IFNG IL10 IL1B TLR2 TLR4
32 toxoplasmosis 28.2 CD40LG CD79A IFNG IL10 IL1B TLR4
33 chlamydia 27.9 CD40LG CD79A IFNG IL10 IL1B TLR2
34 melioidosis 27.8 IFNG IL10 TLR1 TLR10 TLR2 TLR4
35 tick infestation 10.9
36 punctate inner choroidopathy 10.6 IL10 TNF
37 tropical endomyocardial fibrosis 10.6 IL10 TNF
38 microscopic polyangiitis 10.6 IL10 TNF
39 multifocal choroiditis 10.6 IL10 TNF
40 tungiasis 10.6 IL10 TNF
41 endomyocardial fibrosis 10.5 IL10 TNF
42 hyperlucent lung 10.5 IFNG IL10
43 transient hypogammaglobulinemia 10.5 IL10 TNF
44 polyposis, gastric 10.5 IL1B TNF
45 choroiditis 10.5 IL10 TNF
46 autoimmune myocarditis 10.5 IFNG TNF
47 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
48 chronic beryllium disease 10.5 IFNG TNF
49 kashin-beck disease 10.5 IL1B TNF
50 trichosporonosis 10.5 IFNG TNF

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Symptoms:

12
  • fever
  • headache
  • cough
  • pleuritic chest pain
  • myalgia
  • arthralgia

MGI Mouse Phenotypes related to Q Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 TLR2 IFNG TLR4 IL10 ARG1 IL1B
2 immune system MP:0005387 10.07 TLR1 CD79A TLR2 IFNG TLR4 IL10
3 homeostasis/metabolism MP:0005376 10.06 CD79A TLR2 IFNG IL10 ARG1 CD40LG
4 integument MP:0010771 9.87 TLR2 IFNG TLR4 IL10 CD40LG IL1B
5 liver/biliary system MP:0005370 9.8 CD79A TLR2 IFNG TLR4 IL10 ARG1
6 neoplasm MP:0002006 9.7 CD79A TLR2 IFNG TLR4 IL10 IL1B
7 nervous system MP:0003631 9.61 CD79A TLR2 IFNG TLR4 IL10 ARG1
8 skeleton MP:0005390 9.17 TLR2 IFNG IL10 CD40LG IL1B TLR4

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4
6 Antimalarials Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Liver Extracts Phase 4
10 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4 Doxycycline;Placebo
2 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
3 Safety and Immunogenicity of Q Fever Vaccine Withdrawn NCT02092142 Phase 2
4 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328
5 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
6 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
7 Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island Completed NCT02898402
8 Q Fever and Auto-immunity Recruiting NCT02822807
9 Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Not yet recruiting NCT03334019

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

38
Testes, Liver, Monocytes, Bone, Bone Marrow, Endothelial, T Cells

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 694)
# Title Authors Year
1
Farming, Q fever and public health: agricultural practices and beyond. ( 29321921 )
2018
2
Q fever epidemic in Cayenne, French Guiana, epidemiologically linked to three-toed sloth. ( 29406281 )
2018
3
Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area. ( 29426406 )
2018
4
Vascular infection and vertebral destruction in a patient with Q fever. ( 29412972 )
2018
5
Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia. ( 29336685 )
2018
6
Understanding Q Fever Risk to Humans in Minnesota Through the Analysis of Spatiotemporal Trends. ( 29261435 )
2018
7
The First Serological Study of Q Fever in Humans in Lebanon. ( 29336692 )
2018
8
Draft Genome Sequence of<i>Coxiella burnetii</i>Historical Strain Leningrad-2, Isolated from Blood of a Patient with Acute Q Fever in Saint Petersburg, Russia. ( 29348343 )
2018
9
The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever. ( 29325142 )
2018
10
Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature. ( 29440832 )
2018
11
Tache Noire in a Patient with Acute Q Fever. ( 29298443 )
2018
12
Chronic Q Fever Infections in Israeli Children - A 25-Year Nationwide Study. ( 28938256 )
2017
13
Seroprevalence and risk factors for <i>Coxiella burnetii</i>, the causative agent of Q fever in the dromedary camel (<i>Camelus dromedarius</i>) population in Algeria. ( 28893076 )
2017
14
Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study. ( 28723794 )
2017
15
Workshop on Q fever. ( 28854800 )
2017
16
Coxiella burnetii infection (Q fever) mimicking systemic lupus erythematosus: two cases. ( 29251170 )
2017
17
Seroprevalence of rickettsial infections and Q fever in Bhutan. ( 29176880 )
2017
18
Q fever prosthetic joint infection. ( 28739619 )
2017
19
Retrospective Examination of Q Fever Endocarditis: An Underdiagnosed Disease in the Mainland of China. ( 28051025 )
2017
20
Unreliability of three commercial<i>Coxiella burnetii</i>phase II IgM ELISA kits for the seroscreening of acute Q fever in human cases. ( 29355147 )
2017
21
A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q Fever. ( 28868312 )
2017
22
Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever. ( 28549166 )
2017
23
Pulmonary manifestations of Q fever: analysis of 38 patients. ( 29268408 )
2017
24
Presentation and diagnosis of acute Q fever in Portugal - A case series. ( 28070491 )
2017
25
Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development. ( 28854806 )
2017
26
The clinical challenge of chronic Q fever with isolated liver involvement. ( 28715899 )
2017
27
Draft Genome Sequences of Three Coxiella burnetii Strains Isolated from Q Fever Patients. ( 28935742 )
2017
28
Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. ( 28709838 )
2017
29
Seroprevalence of Leptospirosis, Brucellosis, and Q Fever in a Wild Red Deer (Cervus elaphus) Population Kept in a Fenced Reserve in Absence of Contact with Livestock. ( 28873022 )
2017
30
Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity. ( 28779434 )
2017
31
Atypical outbreak of Q fever affecting low-risk residents of a remote rural town in New South Wales. ( 28899307 )
2017
32
Seroepidemiological study of Q fever in Lorestan province, western Iran, 2014. ( 29238456 )
2017
33
Reprint of "Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern CA'te d'Ivoire". ( 28867393 )
2017
34
Dot map cartograms for detection of infectious disease outbreaks: an application to Q fever, the Netherlands and pertussis, Germany. ( 28681721 )
2017
35
Epidemiology of Q fever in Iran: A systematic review and meta-analysis for estimating serological and molecular prevalence. ( 29259632 )
2017
36
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
37
Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass. ( 29270326 )
2017
38
Molecular detection of Coxiella burnetii from the formalin-fixed tissues of Q fever patients with acute hepatitis. ( 28672014 )
2017
39
From Q Fever to Coxiella burnetii Infection: a Paradigm Change. ( 27856520 )
2017
40
CXCL9, a promising biomarker in the diagnosis of chronic Q fever. ( 28793883 )
2017
41
Diagnosis of Acute Q Fever by Detection of<i>Coxiella burnetii</i>DNA using Real-Time PCR, Employing a Commercial Genesig Easy Kit. ( 29207703 )
2017
42
A case of Q fever with erythema nodosum. ( 28819912 )
2017
43
Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic. ( 29157226 )
2017
44
First Case of Q Fever Endocarditis Involving the Melody(Ar) Transcatheter Pulmonary Valve in an Afebrile Child. ( 28948320 )
2017
45
Chronic Recurrent Multifocal Q Fever Osteomyelitis in Children: An Emerging Clinical Challenge. ( 27294309 )
2016
46
A Case of Silent Q Fever Endocarditis. ( 28810106 )
2016
47
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. ( 27966835 )
2016
48
Q Fever Pneumonia in Southwest Germany: RadiographicA and Clinical Findings. ( 28002852 )
2016
49
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. ( 28036394 )
2016
50
A fatal case of disseminated chronic Q fever: a case report and brief review of the literature. ( 26940462 )
2016

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ARG1 CD40LG CD79A IFNG IL10 IL1B
2
Show member pathways
13.39 CD40LG IL10 IL1B TLR1 TLR10 TLR2
3
Show member pathways
13.2 CD79A IFNG IL1B TLR1 TLR10 TLR2
4
Show member pathways
12.97 IL1B TLR1 TLR10 TLR2 TLR4 TNF
5
Show member pathways
12.85 CD40LG IFNG IL10 IL1B TNF
6
Show member pathways
12.79 IFNG IL1B TLR2 TLR4 TNF
7
Show member pathways
12.69 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
8
Show member pathways
12.64 CD40LG CD79A IFNG IL10 TNF
9
Show member pathways
12.63 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
10
Show member pathways
12.62 CD40LG IFNG IL1B TNF
11
Show member pathways
12.62 IFNG IL10 IL1B TLR2 TLR4 TNF
12
Show member pathways
12.55 IFNG IL10 IL1B TNF
13
Show member pathways
12.49 IFNG IL10 IL1B TLR1 TLR2 TLR4
14
Show member pathways
12.47 CD40LG IFNG IL10 IL1B TNF
15 12.37 CD40LG CD79A IFNG IL10 IL1B TLR1
16
Show member pathways
12.34 IFNG IL1B TLR2 TNF
17
Show member pathways
12.3 TLR1 TLR10 TLR2 TLR4 TNF
18
Show member pathways
12.28 IFNG IL1B TLR4 TNF
19
Show member pathways
12.23 IFNG IL1B TLR4 TNF
20
Show member pathways
12.19 IFNG IL1B TLR1 TLR2 TLR4 TNF
21
Show member pathways
12.18 IFNG IL10 IL1B TNF
22
Show member pathways
12.18 CD40LG IFNG IL10 IL1B TLR2 TLR4
23 12.17 IFNG TLR1 TLR10 TLR2 TLR4 TNF
24 12.12 IFNG IL10 IL1B TLR1 TLR2 TLR4
25 12.1 TLR1 TLR10 TLR2 TLR4
26
Show member pathways
12.09 IL1B TLR1 TLR10 TLR2 TLR4
27 12.07 ARG1 IFNG IL1B TLR4 TNF
28 12.04 IFNG IL1B TNF
29 12.03 CD79A IFNG IL10 TNF
30 12.01 IFNG IL1B TNF
31 11.95 IL10 IL1B TNF
32 11.94 CD40LG IL1B TLR4 TNF
33 11.89 TLR1 TLR10 TLR2 TLR4
34 11.89 IFNG IL1B TLR2 TLR4 TNF
35 11.85 IFNG IL10 IL1B TNF
36
Show member pathways
11.84 IFNG IL1B TLR1 TLR10 TLR2 TLR4
37 11.82 IFNG IL1B TLR4
38 11.82 IL10 IL1B TLR4 TNF
39 11.81 IFNG IL10 IL1B TNF
40
Show member pathways
11.77 CD40LG IFNG TNF
41 11.73 CD40LG IL10 TLR2 TLR4 TNF
42
Show member pathways
11.72 CD40LG IFNG IL1B TNF
43 11.68 ARG1 CD40LG IL10
44 11.68 ARG1 IFNG IL10 IL1B TLR2 TLR4
45 11.66 IL1B TLR2 TLR4 TNF
46 11.57 IL10 IL1B TNF
47
Show member pathways
11.57 IFNG IL10 IL1B TLR1 TLR10 TLR2
48 11.56 IFNG IL1B TNF
49 11.52 IFNG IL1B TNF
50 11.51 IFNG IL1B TLR2 TLR4 TNF

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.56 CD40LG CD79A TLR4 TNF
2 integral component of plasma membrane GO:0005887 9.5 CD40LG CD79A TLR1 TLR10 TLR2 TLR4
3 membrane raft GO:0045121 9.46 CD79A TLR1 TLR2 TNF
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.96 IL10 TLR1 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.93 ARG1 IL10 IL1B TLR2 TLR4
3 cellular response to lipopolysaccharide GO:0071222 9.9 ARG1 IL10 TLR4 TNF
4 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.89 IL10 IL1B TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL1B TLR2 TLR4 TNF
7 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
8 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
9 B cell differentiation GO:0030183 9.85 CD40LG CD79A IL10
10 positive regulation of inflammatory response GO:0050729 9.85 TLR10 TLR2 TLR4
11 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B TLR2 TLR4 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.82 IL1B TLR4 TNF
13 toll-like receptor signaling pathway GO:0002224 9.81 TLR1 TLR10 TLR2 TLR4
14 B cell proliferation GO:0042100 9.79 CD40LG CD79A IL10
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 IFNG IL1B TLR4 TNF
16 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR4 TNF
17 positive regulation of interleukin-10 production GO:0032733 9.76 CD40LG TLR2 TLR4
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.76 TLR1 TLR10 TLR2 TLR4
19 positive regulation of chemokine production GO:0032722 9.75 TLR2 TLR4 TNF
20 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 IL10 TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.73 IFNG TNF
22 defense response to protozoan GO:0042832 9.73 ARG1 IL10
23 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
24 positive regulation of macrophage activation GO:0043032 9.73 IL10 TLR4
25 cell activation GO:0001775 9.73 TLR1 TLR2
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
29 positive regulation of interleukin-8 secretion GO:2000484 9.72 TLR1 TLR2
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 TLR2 TLR4
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
33 response to molecule of bacterial origin GO:0002237 9.71 IL10 TLR2
34 I-kappaB phosphorylation GO:0007252 9.71 TLR2 TLR4
35 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.71 TLR1 TLR4
36 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
37 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TLR4 TNF
38 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
39 macrophage activation GO:0042116 9.7 TLR1 TLR4
40 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
42 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.69 IL1B TLR1
44 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
45 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 TLR4
46 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
47 positive regulation of interleukin-12 production GO:0032735 9.67 CD40LG IFNG TLR2 TLR4
48 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
49 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
50 sequestering of triglyceride GO:0030730 9.65 IL1B TNF

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.46 CD79A TLR1 TLR10 TLR4
2 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
3 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL1B TNF
4 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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