MCID: QFV001
MIFTS: 60

Q Fever malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Q Fever

Aliases & Descriptions for Q Fever:

Name: Q Fever 12 50 56 3 3 42 14 69
Infection Due to Coxiella Burnetii 12 56
Quadrilateral Fever 56 69
Query Fever 50 56
Coxiella Burnetii Fever 50
Pneumonia in Q Fever 69
Q Fever Pneumonia 50
Nine Mile Fever 56
Coxiellosis 56

Characteristics:

Orphanet epidemiological data:

56
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11100
ICD10 33 A78
ICD9CM 35 083.0
MeSH 42 D011778
NCIt 47 C34970
Orphanet 56 ORPHA781
MESH via Orphanet 43 D011778
UMLS via Orphanet 70 C0034362
ICD10 via Orphanet 34 A78
UMLS 69 C0034362

Summaries for Q Fever

NIH Rare Diseases : 50 q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as coxiella burnetii. cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. humans are often very susceptible to the disease, and very few organisms may be required to cause infection. in less than 5% of cases the affected people with acute q fever infection develop a chronic q fever. treatment of the acute form is made with antibiotics. the chronic form's treatment depend on the symptoms. last updated: 7/8/2015

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and hepatitis, and has symptoms including fever, headache and cough. An important gene associated with Q Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Doxycycline and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include testes, monocytes and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia : 71 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
id Related Disease Score Top Affiliating Genes
1 endocarditis 30.9 CD40LG CD79A
2 hepatitis 30.7 IFNG IL10 TNF
3 spotted fever 30.0 CD40LG TLR2 TLR4 TNF
4 uveitis 30.0 CD40LG CD79A TNF
5 tularemia 29.8 CD40LG CD79A IFNG IL10 TNF
6 rift valley fever 29.6 IFNG IL1B TLR4 TNF
7 tuberculosis 29.5 CD40LG IL10 IL1B TNF
8 rickettsialpox 27.4 ARG1 CD40LG CD79A IFNG IL10 IL1B
9 tick infestation 10.7
10 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
11 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
12 intussusception 10.3 IL1B TNF
13 lagophthalmos 10.3 IL10 TNF
14 maturity-onset diabetes of the young 10.3 CD40LG IL10
15 asymptomatic neurosyphilis 10.3 IFNG IL10
16 multiple vertebral anomalies unusual facies 10.3 IL10 TNF
17 tau syndrome 10.3 IL1B TNF
18 autosomal dominant deafness-onychodystrophy syndrome 10.3 IFNG TNF
19 conidiobolomycosis 10.3 IL10 TNF
20 alcoholic neuropathy 10.3 CD40LG CD79A
21 camptodactyly vertebral fusion 10.3 CD40LG CD79A
22 malignant renovascular hypertension 10.3 CD79A IFNG
23 spinal polio 10.2 CD40LG CD79A
24 rabies 10.2 CD40LG CD79A
25 unilateral retinoblastoma 10.2 CD40LG CD79A
26 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
27 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL10 TNF
28 delta chain disease 10.2 CD40LG CD79A
29 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 IL1B TNF
30 cyclosporiasis 10.2 IFNG IL10 TNF
31 discitis 10.2 CD40LG CD79A
32 neurotic disorder 10.2 IFNG IL10 TNF
33 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
34 trichostrongyloidiasis 10.2 CD40LG CD79A
35 toxic optic neuropathy 10.2 CD79A IL1B
36 pulpitis 10.2 IFNG IL10 TNF
37 colloid adenoma 10.2 CD40LG CD79A
38 peripheral artery disease 10.2 IL10 TLR2 TNF
39 heart septal defect 10.2 CD40LG CD79A
40 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL10 TNF
41 erb-duchenne and dejerine-klumpke palsies 10.2 IFNG IL10 TNF
42 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
43 orbital osteomyelitis 10.2 IFNG IL10 TNF
44 mild pre-eclampsia 10.2 CD40LG CD79A
45 retinal microaneurysm 10.2 CD40LG CD79A
46 gonococcal endophthalmia 10.2 IL10 IL1B TNF
47 bladder signet ring cell adenocarcinoma 10.2 IL10 IL1B TNF
48 asbestosis 10.2 IL10 TLR2 TNF
49 pediatric meningioma 10.2 CD40LG CD79A
50 tonsil cancer 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Symptoms:

12
  • fever
  • headache
  • cough
  • pleuritic chest pain
  • myalgia
  • arthralgia

MGI Mouse Phenotypes related to Q Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 TLR2 TLR4 TNF ARG1 CD40LG CD79A
2 immune system MP:0005387 10.07 ARG1 CD40LG CD79A IFNG IL10 IL1B
3 homeostasis/metabolism MP:0005376 10.06 TLR2 TLR4 TNF ARG1 CD40LG CD79A
4 integument MP:0010771 9.87 CD40LG IFNG IL10 IL1B TLR2 TLR4
5 liver/biliary system MP:0005370 9.8 ARG1 CD79A IFNG IL10 TLR2 TLR4
6 neoplasm MP:0002006 9.7 CD79A IFNG IL10 IL1B TLR2 TLR4
7 nervous system MP:0003631 9.61 CD40LG CD79A IFNG IL10 IL1B TLR2
8 skeleton MP:0005390 9.17 CD40LG IFNG IL10 IL1B TLR2 TLR4

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
4
Famotidine Approved Phase 4 76824-35-6 3325
5
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
7
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
8
Quinine Approved Phase 4 130-95-0 8549 3034034
9
Sulfadoxine Approved Phase 4 2447-57-6 17134
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
11
Voriconazole Approved, Investigational Phase 4,Phase 3 137234-62-9 71616
12
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
13
deoxycholic acid Approved Phase 4 83-44-3 222528
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 54575, 6560146 143
16
Butyric Acid Experimental Phase 4 107-92-6 264
17 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
20 Antimalarials Phase 4,Phase 3
21 Antiparasitic Agents Phase 4,Phase 3
22 Antiprotozoal Agents Phase 4,Phase 3
23 Liver Extracts Phase 4
24 Antacids Phase 4,Phase 2
25 Anti-Ulcer Agents Phase 4,Phase 2
26 Gastrointestinal Agents Phase 4,Phase 2
27 Histamine Antagonists Phase 4,Phase 2
28 Histamine H2 Antagonists Phase 4,Phase 2
29
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
30 Neurotransmitter Agents Phase 4,Phase 2
31
Proton pump inhibitors Phase 4
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
33 Cortisol succinate Phase 4
34 Hydrocortisone 17-butyrate 21-propionate Phase 4
35 Hydrocortisone acetate Phase 4
36 Hydrocortisone-17-butyrate Phase 4
37 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
38 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
39 Fanasil, pyrimethamine drug combination Phase 4
40 Folic Acid Antagonists Phase 4,Phase 3,Phase 1,Phase 2
41 Neuromuscular Agents Phase 4
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Renal Agents Phase 4,Phase 3
44 Vitamin B Complex Phase 4,Phase 3,Phase 1,Phase 2
45 Antifungal Agents Phase 4,Phase 3,Phase 1,Phase 2
46 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
47 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
48 Hormone Antagonists Phase 4,Phase 3,Phase 2
49 Hormones Phase 4,Phase 3,Phase 2,Phase 1
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 68)
id Name Status NCT ID Phase
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4
2 Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit Completed NCT00633035 Phase 4
3 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4
4 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
5 Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine Completed NCT00167739 Phase 4
6 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
7 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Recruiting NCT02283905 Phase 4
8 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3
9 Combination Chemotherapy With or Without Filgrastim Before Surgery, High-Dose Chemotherapy, and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma Unknown status NCT00030719 Phase 3
10 Safety and Efficacy of Intravenous Acetaminophen (IV APAP) in Adult Inpatients Completed NCT00598559 Phase 3
11 Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic Patients Completed NCT00150345 Phase 3
12 Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections Completed NCT00427076 Phase 3
13 Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine GSK2282512A When Administered to Children 6 to 35 Months of Age Completed NCT01711736 Phase 3
14 Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine (GSK2282512A) Compared to Fluzone® Quadrivalent in Children 6 to 35 Months of Age Completed NCT02242643 Phase 3
15 Adjuvant Treatment of EC Followed by wP and wPCb in Triple-Negative Breast Cancer Recruiting NCT02455141 Phase 3
16 Neoadjuvant Aromatase Inhibitor(AI) With Ovarian Suppression Versus Chemotherapy in Premenopausal Breast Cancer Patients Recruiting NCT02532400 Phase 3
17 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Recruiting NCT02406729 Phase 3
18 Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers Active, not recruiting NCT02059291 Phase 3
19 Empirical Versus Preemptive Antifungal Therapy Active, not recruiting NCT01288378 Phase 3
20 First-line R-CVP vs R-CHOP Induction Immunochemotherapy for Indolent Lymphoma and R Maintenance. Active, not recruiting NCT00801281 Phase 3
21 Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin Terminated NCT01226992 Phase 2, Phase 3
22 Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia Withdrawn NCT00943709 Phase 3
23 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
24 Study of Danggui Buxue Decoction in Preventing Neutropenia Completed NCT02005783 Phase 2
25 Clinical Trial Corticoids For Empyema And Pleural Effusion In Children Completed NCT01261546 Phase 2
26 Trial Exploring Feasibility of Densification and Optimal Sequencing of Postoperative Adjuvant Fluorouracil, Epirubicin Plus Cyclophosphamide (FEC) and Docetaxel Chemotherapy in Patients With High Risk Primary Operable Breast Cancer Completed NCT00256360 Phase 2
27 A Study of Radiation Therapy and Paclitaxel and Carboplatin in Patients With Uterine Papillary Serous Carcinoma Completed NCT00231868 Phase 2
28 Lapatinib in Combination With Docetaxel in Patients With HER-2 Positive Advanced or Metastatic Breast Cancer Completed NCT01044485 Phase 1, Phase 2
29 A Clinical Trial to Test How Well Two Drugs, QAW039 and Montelukast Work Both Individually and Together, to Target Allergic Rhinitis Using an Environmental Exposure Chamber Completed NCT01804400 Phase 2
30 Evaluation of the Efficacy and Safety of Peramivir in Subjects With Uncomplicated Acute Influenza. Completed NCT00419263 Phase 2
31 Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine GSK2282512A When Administered to Children From 6 to 35 Months of Age Completed NCT01974895 Phase 2
32 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2
33 Reduction of Intrapartum Fever With Intravenous Acetaminophen Recruiting NCT02625454 Phase 2
34 Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant Recruiting NCT03078010 Phase 2
35 A Prospective, Multicenter, Open-label 12 Week Neoadjuvant Phase II Trial Optimizing Taxane Therapy in Elderly Patients With Low Response Recruiting NCT02214381 Phase 2
36 Histopathological Response to FOLFOXIRI + Bevacizumab in Peritoneal Metastasis From Colorectal Cancer Recruiting NCT02591667 Phase 2
37 Tocilizumab for KSHV-Associated Multicentric Castleman Disease Recruiting NCT01441063 Phase 2
38 Impact of CD34+ Cell Dose on Progression-free Survival Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL) Recruiting NCT02570542 Phase 2
39 Two Different Regimens of Misoprostol in Retained Placenta Recruiting NCT02704780 Phase 2
40 A Trial Comparing Two Medications as First Treatment in Elderly Patients With Metastatic or Advanced Soft Tissue Sarcoma Active, not recruiting NCT01861951 Phase 2
41 Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore Not yet recruiting NCT02569827 Phase 1, Phase 2
42 Safety and Immunogenicity of Q Fever Vaccine Terminated NCT02092142 Phase 2
43 Efficacy and Tolerability of Eribulin Plus Lapatinib in Patients With Metastatic Breast Cancer (E-VITA) Terminated NCT01534455 Phase 2
44 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2
45 Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients Completed NCT00493246 Phase 1
46 Study to Evaluate the Immunogenicity and Safety of an Ebola Virus (EBOV) Glycoprotein (GP) Vaccine in Healthy Subjects Completed NCT02370589 Phase 1
47 Apatinib and Irinotecan Combination Treatment in Esophageal Squamous Cell Carcinoma Recruiting NCT02645864 Phase 1
48 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328
49 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
50 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

39
Testes, Monocytes, Bone, Bone Marrow, T Cells, Endothelial, Prostate

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 653)
id Title Authors Year
1
Retrospective Examination of Q Fever Endocarditis: An Underdiagnosed Disease in the Mainland of China. ( 28051025 )
2017
2
Presentation and diagnosis of acute Q fever in Portugal - A case series. ( 28070491 )
2017
3
From Q Fever to Coxiella burnetii Infection: a Paradigm Change. ( 27856520 )
2017
4
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
5
Q Fever in French Guiana: Tip of the Iceberg or Epidemiological Exception? ( 27149385 )
2016
6
Febrile patients admitted to remote hospitals in Northeastern Kenya: seroprevalence, risk factors and a clinical prediction tool for Q-Fever. ( 27260261 )
2016
7
The natural history of acute Q fever: a prospective Australian cohort. ( 27037328 )
2016
8
Intact interferon-I^ response against Coxiella burnetii by peripheral blood mononuclear cells in chronic Q fever. ( 27876593 )
2016
9
Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy. ( 27656302 )
2016
10
The first case of chronic Q fever endocarditis and aortitis from Turkey: A 5-year infection before diagnosis with drain in sternum. ( 27723671 )
2016
11
Seroprevalence of Q Fever in Patients Undergoing Heart Valve Replacement Surgery. ( 27989050 )
2016
12
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. ( 27966835 )
2016
13
Q fever is an old and neglected zoonotic disease in Kenya: a systematic review. ( 27048480 )
2016
14
Lyophilization to improve the sensitivity of qPCR for bacterial DNA detection in serum: the Q fever paradigm. ( 27008653 )
2016
15
Chronic Q fever leads to dilated cardiomyopathy in a 48-year-old male. ( 27521543 )
2016
16
Q fever: a contemporary case series from a Belgian hospital. ( 27118360 )
2016
17
Q fever seroprevalence and risk factors in sheep and goats in northwest Italy. ( 27435642 )
2016
18
Seroprevalence of Q Fever (Coxiellosis) in Small Ruminants of Two Districts in Punjab, Pakistan. ( 27172109 )
2016
19
Coxiella burnetii (Q Fever) Seropositivity and Associated Risk Factors in Sheep and Goat Farm Workers in Ontario, Canada. ( 27585364 )
2016
20
Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern CA'te d'Ivoire. ( 26899680 )
2016
21
Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease. ( 27571945 )
2016
22
Waning population immunity prior to a large Q fever epidemic in the south of The Netherlands. ( 27075042 )
2016
23
Q Fever. ( 26874100 )
2016
24
Detection of Coxiella burnetii in Ambient Air after a Large Q Fever Outbreak. ( 26991094 )
2016
25
Seroprevalence of Q Fever, Brucellosis, and Bluetongue in Selected Provinces in Lao People's Democratic Republic. ( 27430548 )
2016
26
18F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series. ( 27559944 )
2016
27
Q fever and contact with kangaroos in New South Wales. ( 27522129 )
2016
28
Use of a Dose-Response Model to Study Temporal Trends in Spatial Exposure to Coxiella burnetii: Analysis of a Multiyear Outbreak of Q Fever. ( 27549241 )
2016
29
Trends and risk factors for human Q fever in Australia, 1991-2014. ( 27927265 )
2016
30
Fatigue following Acute Q-Fever: A Systematic Literature Review. ( 27223465 )
2016
31
Novel genotypes of Coxiella burnetii identified in isolates from Australian Q fever patients. ( 27283085 )
2016
32
Molecular Identification of Q Fever in Patients with a Suspected Diagnosis of Dengue in Brazil in 2013-2014. ( 26928831 )
2016
33
Q fever hepatitis and endocarditis in the context of haemochromatosis. ( 27873744 )
2016
34
Coxiella burnetii (Q fever) prevalence in associated populations of humans and small ruminants in The Gambia. ( 27987380 )
2016
35
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua. ( 28036394 )
2016
36
Q Fever (Coxiella burnetii) Knowledge and Attitudes of Australian Cat Breeders and Their Husbandry Practices. ( 27621095 )
2016
37
Chronic Recurrent Multifocal Q Fever Osteomyelitis in Children: An Emerging Clinical Challenge. ( 27294309 )
2016
38
Serological and Molecular Evidence of Q Fever in Domestic Ruminants in Bangladesh. ( 27239369 )
2016
39
First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937. ( 27103714 )
2016
40
The contribution of genomics to the study of Q fever. ( 26854360 )
2016
41
Coxiella burnetii Induces Inflammatory Interferon-Like Signature in Plasmacytoid Dendritic Cells: A New Feature of Immune Response in Q Fever. ( 27446817 )
2016
42
Chronic Q fever: A missed prosthetic valve endocarditis possibly for years. ( 27713859 )
2016
43
Q Fever Pneumonia in Southwest Germany: RadiographicA and Clinical Findings. ( 28002852 )
2016
44
Psoas abscess and chronic Q fever: a contiguous or hematogenous complication? A case report and literature review. ( 27167531 )
2016
45
A fatal case of disseminated chronic Q fever: a case report and brief review of the literature. ( 26940462 )
2016
46
Serological and molecular evidence of Q fever among small ruminant flocks in Algeria. ( 27477503 )
2016
47
Endemic Q Fever in New South Wales, Australia: A Case Series (2005-2013). ( 27139451 )
2016
48
Q Fever, Scrub Typhus, and Rickettsial Diseases in Children, Kenya, 2011-2012. ( 27088502 )
2016
49
Q Fever Endocarditis Presenting with Superior Mesenteric Artery Embolism and Renal Infarction. ( 27047296 )
2016
50
Surgical and Antimicrobial Management of a Thoracic Aortic Aneurysm Due to Q Fever: A Case Report and Brief Review. ( 27075992 )
2016

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ARG1 CD40LG CD79A IFNG IL10 IL1B
2
Show member pathways
13.4 CD40LG IL10 IL1B TLR1 TLR10 TLR2
3
Show member pathways
13.19 CD79A IFNG IL1B TLR1 TLR10 TLR2
4
Show member pathways
12.99 IL1B TLR1 TLR10 TLR2 TLR4 TNF
5
Show member pathways
12.93 IFNG IL10 IL1B TLR1 TLR2 TLR4
6
Show member pathways
12.84 CD40LG IFNG IL10 IL1B TNF
7
Show member pathways
12.79 IFNG IL1B TLR2 TLR4 TNF
8
Show member pathways
12.67 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
9
Show member pathways
12.64 CD40LG CD79A IFNG IL10 TNF
10
Show member pathways
12.63 IFNG IL10 IL1B TLR2 TLR4 TNF
11
Show member pathways
12.62 CD40LG IFNG IL1B TNF
12
Show member pathways
12.62 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
13
Show member pathways
12.55 IFNG IL10 IL1B TNF
14
Show member pathways
12.47 CD40LG IFNG IL10 IL1B TNF
15 12.35 CD40LG CD79A IFNG IL10 IL1B TLR1
16
Show member pathways
12.34 IFNG IL1B TLR2 TNF
17
Show member pathways
12.3 TLR1 TLR10 TLR2 TLR4 TNF
18
Show member pathways
12.28 IFNG IL1B TLR4 TNF
19
Show member pathways
12.18 IFNG IL10 IL1B TNF
20
Show member pathways
12.18 CD40LG IFNG IL10 IL1B TLR2 TLR4
21
Show member pathways
12.17 IFNG IL1B TLR1 TLR2 TLR4 TNF
22 12.15 IFNG TLR1 TLR10 TLR2 TLR4 TNF
23 12.12 IFNG IL10 IL1B TLR1 TLR2 TLR4
24 12.11 TLR1 TLR10 TLR2 TLR4
25
Show member pathways
12.08 IL1B TLR1 TLR10 TLR2 TLR4
26 12.06 ARG1 IFNG IL1B TLR4 TNF
27 12.04 IFNG IL1B TNF
28 12.04 CD79A IFNG IL10 TNF
29 12 IFNG IL1B TNF
30 11.95 IL10 IL1B TNF
31 11.94 CD40LG IL1B TLR4 TNF
32 11.89 TLR1 TLR10 TLR2 TLR4
33 11.89 IFNG IL1B TLR2 TLR4 TNF
34
Show member pathways
11.89 IFNG IL1B TLR1 TLR10 TLR2 TLR4
35 11.85 IFNG IL10 IL1B TNF
36 11.82 IFNG IL1B TLR4
37 11.82 IFNG IL10 IL1B TNF
38 11.82 IL10 IL1B TLR4 TNF
39
Show member pathways
11.77 CD40LG IFNG TNF
40 11.74 CD40LG IL10 TLR2 TLR4 TNF
41
Show member pathways
11.72 CD40LG IFNG IL1B TNF
42 11.68 ARG1 CD40LG IL10
43 11.68 ARG1 IFNG IL10 IL1B TLR2 TLR4
44 11.66 IL1B TLR2 TLR4 TNF
45
Show member pathways
11.59 IFNG IL10 IL1B TLR1 TLR10 TLR2
46 11.56 IL10 IL1B TNF
47 11.55 IFNG IL1B TNF
48 11.52 IFNG IL1B TNF
49 11.51 IFNG IL1B TLR2 TLR4 TNF
50
Show member pathways
11.46 IFNG IL10 TNF

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ARG1 CD40LG IFNG IL10 IL1B TNF
2 integral component of plasma membrane GO:0005887 9.7 CD40LG CD79A TLR1 TLR10 TLR2 TLR4
3 membrane raft GO:0045121 9.56 CD79A TLR1 TLR2 TNF
4 external side of plasma membrane GO:0009897 9.02 CD40LG CD79A IFNG TLR4 TNF
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IFNG IL10 TLR1 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.98 ARG1 IL10 IL1B TLR2 TLR4
3 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 IL10 IL1B TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL1B TLR2 TLR4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.88 ARG1 IFNG IL10 TLR4 TNF
7 B cell differentiation GO:0030183 9.87 CD40LG CD79A IL10
8 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
9 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
10 positive regulation of T cell proliferation GO:0042102 9.86 CD40LG IFNG IL1B
11 positive regulation of inflammatory response GO:0050729 9.85 TLR10 TLR2 TLR4
12 positive regulation of tumor necrosis factor production GO:0032760 9.84 IFNG TLR2 TLR4
13 toll-like receptor signaling pathway GO:0002224 9.84 TLR1 TLR10 TLR2 TLR4
14 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B TLR2 TLR4 TNF
16 B cell proliferation GO:0042100 9.82 CD40LG CD79A IL10
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IFNG IL1B TLR4 TNF
18 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TNF
19 positive regulation of interleukin-10 production GO:0032733 9.79 CD40LG TLR2 TLR4
20 positive regulation of chemokine production GO:0032722 9.79 TLR2 TLR4 TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.78 IFNG IL10 TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG IL1B TNF
23 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.76 TLR1 TLR10 TLR2 TLR4
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL10 IL1B TNF
25 positive regulation of osteoclast differentiation GO:0045672 9.74 IFNG TNF
26 defense response to protozoan GO:0042832 9.74 IFNG IL10
27 positive regulation of chemokine biosynthetic process GO:0045080 9.74 IFNG IL1B TNF
28 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
29 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 IL10 TNF
30 cell activation GO:0001775 9.73 TLR1 TLR2
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4
32 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
33 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.73 IFNG IL1B TLR1
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
35 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
36 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
37 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TLR4
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IFNG IL10 TLR4
39 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.71 TLR1 TLR4
40 macrophage activation GO:0042116 9.71 TLR1 TLR4
41 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
42 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
43 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
44 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TLR4 TNF
45 regulation of defense response to virus by host GO:0050691 9.7 IFNG IL1B
46 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
47 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
48 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.68 IFNG TLR4
49 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
50 regulation of immunoglobulin secretion GO:0051023 9.67 CD40LG TNF

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.35 CD79A TLR1 TLR10 TLR2 TLR4
2 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL1B TNF

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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