MCID: QFV001
MIFTS: 56

Q Fever malady

Infectious category

Summaries for Q Fever

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards: Q Fever, also known as infection due to coxiella burnetii, is related to hepatitis c and scrub typhus, and has symptoms including cough, fever and headache. An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways are NF-kappa B signaling pathway and Amoebiasis. The compounds p003 and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and lung, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:64 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
q fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

q fever 8 43 10 49 61
infection due to coxiella burnetii 8
coxiella burnetii fever 43
pneumonia in q fever 61
q fever pneumonia 43
query fever 43


External Ids:

Disease Ontology8 DOID:11100
NCIt40 C34970
MeSH35 D011778
ICD9CM27 083.0
MESH via Orphanet36 D011778
ICD10 via Orphanet26 A78
SNOMED-CT via Orphanet58 186788009, 68981009
UMLS via Orphanet62 C0034362
ICD1025 A78

Related Diseases for Q Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Q Fever family:

recurrent fever multi-gene panels

Diseases related to Q Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.8GPT, IL1R1, CD40LG, ARG1
2scrub typhus30.5GPT, CD40LG
3leptospirosis30.5CD40LG
4uveitis30.4CD14, IL1R1
5cryoglobulinemia30.2APOH, CD40LG
6arthritis30.2IL1RN, IL1R1, SLC11A1, SELE
7thyroiditis30.0MBL2
8hepatitis b30.0MBL2, GPT
9viral hepatitis30.0CD14, GPT
10antiphospholipid syndrome30.0APOH, CD40LG, SELE
11tuberculosis30.0MBL2, SLC11A1, SELL, ADA
12nephritis30.0APOH, CD40LG, IL1RN, IL1R1
13systemic lupus erythematosus30.0MBL2, APOH, CD40LG, IL1RN, IL1R1, SELE
14typhus10.6
15granulomatous hepatitis10.5
16hepatitis a10.5
17spotted fever10.5
18chronic fatigue syndrome10.4
19tularemia10.4
20acalculous cholecystitis10.3
21rickettsialpox10.2
22splenic infarction10.2
23hepatitis d10.2
24lymphogranuloma venereum10.2
25aortic aneurysm10.2
26thrombophlebitis10.2
27acute thyroiditis10.0
28pyuria10.0
29mononeuritis multiplex10.0
30campylobacteriosis10.0
31miller fisher syndrome10.0
32hypophosphatemia10.0
33ornithosis10.0
34hepatitis e10.0
35glanders10.0
36endemic typhus10.0
37trench fever10.0
38lymphocytic choriomeningitis10.0
39ross river fever10.0
40proliferative glomerulonephritis10.0
41thrombocytosis10.0
42viral pneumonia10.0
43aortitis10.0
44melioidosis10.0
45miliary tuberculosis10.0
46lyme disease10.0
47autoimmune hemolytic anemia10.0
48placental abruption10.0
49infectious mononucleosis10.0
50hypersplenism10.0

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Clinical Features for Q Fever

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 6)
  • cough
  • fever
  • headache
  • pleuritic chest pain
  • myalgia
  • arthralgia

Drugs & Therapeutics for Q Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Q Fever

Drug clinical trials:

Search ClinicalTrials for Q Fever

Search NIH Clinical Center for Q Fever

Search CenterWatch for Q Fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

Sources:
33MalaCards
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MalaCards organs/tissues related to Q Fever:

33
Liver, Lymph node, Lung, Bone marrow, Cortex, Heart, Thyroid, Placenta, Tonsil, T cells, B cells

Animal Models for Q Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Q Fever

Sources:
51PubMed
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Articles related to Q Fever:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
Serology in chronic Q fever is still surrounded by question marks. (24430618)
2014
2
Typhoid fever in paediatric patients in Quetta, Balochistan, Pakistan. (24353661)
2013
3
Spotted fever group rickettsiae in questing ticks, central Spain. (23763913)
2013
4
How Brazil joined the quest for a yellow fever vaccine. Interview by Claudia Jurberg and Julia D'Aloisio.. (23476088)
2013
5
Assessing health status and quality of life of Q-fever patients: the Nijmegen Clinical Screening Instrument versus the Short Form 36. (23826639)
2013
6
Microevolution of the chromosomal region of acute disease antigen A (adaA) in the query (Q) fever agent Coxiella burnetii. (23301072)
2013
7
International external quality assessment of molecular detection of Rift Valley fever virus. (23717706)
2013
8
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. (23517327)
2013
9
Localizing chronic Q fever: a challenging query. (24004470)
2013
10
Multiple "doughnut" granulomas in Coxiella burnetii infection (Q fever). (24344452)
2013
11
Q fever: new insights, still many queries. (22297098)
2012
12
A flow cytometry-based assay for quantifying non-plaque forming strains of yellow fever virus. (23028428)
2012
13
Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever. (22371897)
2012
14
Health-related quality of life and the prevalence of post-traumatic stress disorder among Crimean-Congo hemorrhagic fever survivors. (22996211)
2012
15
Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands. (21784920)
2011
16
Cases of malaria, hepatitis A, and typhoid fever among VFRs, Quebec (Canada). (22017712)
2011
17
Multiplex 5' nuclease-quantitative PCR for diagnosis of relapsing fever in a large Tanzanian cohort. (21775542)
2011
18
Apropos "chikungunya fever in the United States: a fifteen-year review of cases". (21498388)
2011
19
Re-infection of typhoid fever and typhoid vaccine (comment on "An imported enteric fever caused by a quinolone-resistant Salmonella typhi"). (21403404)
2011
20
Q fever: still more queries than answers. (22125041)
2011
21
Infectious diseases. Questions abound in Q-fever explosion in the Netherlands. (20075230)
2010
22
Combined mutation and rearrangement screening by quantitative PCR high-resolution melting: is it relevant for hereditary recurrent Fever genes? (21124859)
2010
23
Acute rheumatic fever in Indigenous people in North Queensland: some good news at last? (20477734)
2010
24
Assessment of a quantitative multiplex 5' nuclease real-time PCR for spotted fever and typhus group rickettsioses and Orientia tsutsugamushi. (19438655)
2009
25
Response to "Case of yellow fever vaccine-associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes". (19281308)
2009
26
DEBATE (see Elaldi N et al, Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: a quasi-experimental study from Turkey. Journal of Infection 2009; 58: 238-244): Biases and misinterpretation in the assessment of the efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever. (19699762)
2009
27
Cluster-sample surveys and lot quality assurance sampling to evaluate yellow fever immunisation coverage following a national campaign, Bolivia, 2007. (19187516)
2009
28
"Doughnut" granulomas from erythema nodosum in acute Q fever. (18494244)
2008
29
Questions on Mediterranean spotted fever a century after its discovery. (18760001)
2008
30
Standardized quantitative RT-PCR assays for quantitation of yellow fever and chimeric yellow fever-dengue vaccines. (18501437)
2008
31
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. (17446442)
2007
32
Highly sensitive and broadly reactive quantitative reverse transcription-PCR assay for high-throughput detection of Rift Valley fever virus. (17804663)
2007
33
Vector competence of Kenyan Culex zombaensis and Culex quinquefasciatus mosquitoes for Rift Valley fever virus. (18240513)
2007
34
Detection of Colorado Tick Fever viral RNA in acute human serum samples by a quantitative real-time RT-PCR assay. (17126919)
2007
35
Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone. (17620650)
2007
36
Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung. (15859662)
2005
37
"Preliminary report of the beneficial effect of chloromycetin in the treatment of typhoid fever"--a commentary. (16331874)
2004
38
Patient views on the management of rheumatic fever and rheumatic heart disease in the Kimberley: a qualitative study. (14678407)
2003
39
Mild rhabdomyolysis in a child with fever and "hematuria". (12736809)
2003
40
Bartonella quintana and urban trench fever. (10913410)
2000
41
Genetic classification of "Rickettsia heilongjiangii" and "Rickettsia hulinii," two Chinese spotted fever group rickettsiae. (10970415)
2000
42
Seroepidemiologic study of three zoonoses (leptospirosis, Q fever, and tularemia) among trappers in QuAcbec, Canada. (7583933)
1995
43
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. (6742814)
1984
44
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). (13120859)
1953
45
A QUANTITATIVE STUDY OF THE SCARLET FEVER TOXIN-ANTITOXIN FLOCCULATION REACTION. (19871154)
1941
46
SCARLET FEVER: ITS PRESENT TREATMENT; THE DIAGNOSIS OF INDEFINITE CASES; AND THE RELEASE FROM QUARANTINE. (20317901)
1930
47
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. (20769352)
1919
48
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. (20768358)
1916
49
The AEtiology and Epidemiology of Paratyphoid Fever and "Food-poisoning.". (19975429)
1911
50
NOTES ON A CASE OF QUININE HAEMOGLOBINURIA OR BLACKWATER FEVER. (20762926)
1906

Genetic Variations for Q Fever

Expression for genes affiliated with Q Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for genes affiliated with Q Fever

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Q Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL1R1, CD14, CD40LG
210.1IL1R1, CD14, ARG1
3
Immune response Bacterial infections in normal airways
Hide members
10.1IL1R1, IL1RN, CD14

Compounds for genes affiliated with Q Fever

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Q Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1p0034510.7APOH
2phosphatidylserine45 29 1112.6CD14, APOH
3glucuronoxylomannan4510.5CD40LG, CD14, SELL
4slea4510.5CD40LG, SELL, SELE
5endotoxin4510.5APOH, ARG1, SELL, SELE
6dextran sulfate4510.5APOH, CD40LG, SELL
7tuberculin4510.4MBL2, CD40LG, CD14, ADA
8cuprophan4510.4CD14, IL1RN, IL1R1, SELL
9polysulfone4510.4CD14, IL1RN, IL1R1, SELL
10gold sodium thiomalate4510.4CD14, IL1RN, IL1R1, SELE
11sulfasalazine45 29 50 1113.4CD40LG, IL1RN, IL1R1, SELE
12polymyxin b4510.4MBL2, CD14, IL1RN, SELE
13hydroxychloroquine45 1111.4IL1R1, CD40LG, APOH
14rantes4510.4MBL2, CD40LG, CD14, IL1R1, SELL
15prednisolone45 29 1112.3MBL2, APOH, CD14, IL1R1, SELL
16lactose45 1111.3SELE, SELL, CD40LG, MBL2
17peptidoglycan45 2911.3MBL2, CD14, IL1RN, IL1R1
18infliximab45 50 1112.3APOH, IL1RN, IL1R1, SELE
19ivig4510.3APOH, CD40LG, IL1RN, IL1R1, GPT
20ribavirin45 50 1112.3MBL2, CD40LG, GPT, ADA
21polyethylene glycol4510.3CD40LG, IL1RN, IL1R1, SELE, ADA
22atorvastatin45 50 29 11 2414.3CD40LG, IL1RN, GPT, SELL, SELE
23pentoxifylline45 1111.3CD14, IL1RN, IL1R1, SELL
24mannose4510.2MBL2, APOH, CD14, IL1RN, SLC11A1
25carbohydrates4510.2MBL2, CD40LG, CD14, IL1RN, SELL, SELE
26lipoteichoic acid4510.2MBL2, APOH, CD14, IL1RN, IL1R1, SELE
27vitamin b124510.2APOH, CD40LG, GPT, ADA
28epinephrine45 11 2412.2CD40LG, IL1RN, IL1R1, SELL, SELE, ADA
29vitamin d4510.1MBL2, CD14, IL1RN, IL1R1, GPT, SLC11A1
30methotrexate45 50 1112.1APOH, IL1RN, IL1R1, GPT, SELE, ADA
31pge14510.1APOH, IL1RN, GPT, SELL
32amphotericin b4510.1IL1RN, IL1R1, ADA
33histamine45 29 2412.1CD40LG, CD14, IL1RN, SELL, SELE, ADA
34neopterin4510.1ADA, GPT, IL1R1, IL1RN, CD14, CD40LG
35aspirin45 50 29 2413.1APOH, CD40LG, IL1RN, IL1R1, SELL, SELE
36aspartate4510.1MBL2, CD40LG, CD14, GPT, SLC11A1, SELE
37indomethacin45 60 29 1113.1IL1R1
38heparin45 29 11 2413.0APOH, CD40LG, CD14, IL1RN, IL1R1, SELL
39latex4510.0IL1RN, CD14, APOH, MBL2
40fibrinogen4510.0MBL2, APOH, CD40LG, CD14, IL1RN, IL1R1
41cyclosporin a45 29 6011.9CD40LG, CD14, IL1RN, IL1R1, GPT, ADA
42cholesterol45 29 11 2412.9MBL2, APOH, CD14, IL1RN, IL1R1, GPT
43alanine459.9CD40LG, CD14, IL1RN, IL1R1, GPT, SELL
44glutamate459.8APOH, ARG1, CD40LG, IL1RN, IL1R1, GPT
45lactate459.8APOH, CD40LG, CD14, IL1RN, IL1R1, GPT
46dexamethasone45 50 29 1112.8MBL2, CD40LG, CD14, IL1RN, IL1R1, SELL
47vegf459.8MBL2, APOH, ARG1, CD40LG, CD14, IL1RN
48creatinine459.7MBL2, APOH, CD40LG, CD14, IL1RN, IL1R1
49arginine459.7APOH, ARG1, CD40LG, CD14, IL1R1, GPT
50nitric oxide45 11 2411.6MBL2, APOH, ARG1, IL1RN, IL1R1, SLC11A1

GO Terms for genes affiliated with Q Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.9ADA, IL1R1, CD14, APOH, MBL2
2extracellular spaceGO:0056159.2ADA, MBL2, APOH, ARG1, CD40LG, CD14

Biological processes related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.9SELE, SLC11A1, NMI, CD14, CD40LG

Products for genes affiliated with Q Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Q Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet