MCID: QFV001
MIFTS: 57

Q Fever malady

Genetic diseases, Rare diseases, Infectious diseases categories
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Summaries for Q Fever

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards: Q Fever, also known as infection due to coxiella burnetii, is related to pneumonia and malaria, and has symptoms including arthralgia, myalgia and pleuritic chest pain. An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways is IL4-mediated signaling events. The compounds tuberculin and mannan have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and bone, and related mouse phenotypes are renal/urinary system and immune system.

Disease Ontology:8 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:65 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
q fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

q fever 8 43 10 49 62
infection due to coxiella burnetii 8 49
query fever 43 49
coxiella burnetii fever 43
pneumonia in q fever 62
quadrilateral fever 49
q fever pneumonia 43
nine mile fever 49
coxiellosis 49


External Ids:

Disease Ontology8 DOID:11100
NCIt40 C34970
ICD9CM27 083.0
MeSH35 D011778
MESH via Orphanet36 D011778
ICD10 via Orphanet26 A78
SNOMED-CT via Orphanet59 186788009, 68981009
UMLS via Orphanet63 C0034362
ICD1025 A78

Related Diseases for Q Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Symptoms for Q Fever

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8Disease Ontology
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Symptoms:

8
  • arthralgia
  • myalgia
  • pleuritic chest pain
  • cough
  • headache
  • fever

Drugs & Therapeutics for Q Fever

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Q Fever

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Anatomical Context for Q Fever

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33MalaCards
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MalaCards organs/tissues related to Q Fever:

33
Placenta, Testes, Bone, Monocytes, Bone marrow, T cells, Prostate, Thyroid, Endothelial

Animal Models for Q Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Q Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7CD40LG, MBL2, PER2
2MP:00053878.3MBL2, CD40LG, SLC11A1, ARG1
3MP:00053977.6ARG1, SLC11A1, CD40LG, MBL2, PER2

Publications for Q Fever

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52PubMed
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Articles related to Q Fever:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Serology in chronic Q fever is still surrounded by question marks. (24430618)
2014
2
Spatial relationships in the Q fever outbreaks 2007-2010 in the Netherlands. (23802588)
2014
3
Lookback procedures after postdonation notifications during a Q fever outbreak in the Netherlands. (22803955)
2013
4
Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin. (23293205)
2013
5
Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. (24252152)
2013
6
Recent progress in glycomics and proteomics of the Q fever bacterium Coxiella burnetii. (23600879)
2013
7
The impact of Q fever-phase-specific milk serology for the diagnosis of puerperal and chronic milk shedding of C. burnetii in dairy cows. (24199386)
2013
8
Culture negative prosthetic valve endocarditis in chronic Q fever: an under-recognized entity. (23642595)
2013
9
Epidemiological characteristics of serologically confirmed q Fever cases in South Korea, 2006-2011. (24159527)
2013
10
Self-reported sick leave and long-term health symptoms of Q-fever patients. (22315459)
2012
11
Q fever: new insights, still many queries. (22297098)
2012
12
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
13
Influence of the environment and occupational exposure on the occurrence of Q fever. (23285522)
2012
14
Identification of risk factors for chronic Q fever, the Netherlands. (22469535)
2012
15
Q fever as a cause of recurrent soft-tissue nodules and abscesses in a child. (22209918)
2012
16
Q Fever: an old but still a poorly understood disease. (23213331)
2012
17
Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in The Netherlands. (21756265)
2012
18
Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands. (21784920)
2011
19
In search of hidden Q-fever outbreaks: linking syndromic hospital clusters to infected goat farms. (20478085)
2011
20
Risks, trust and knowledge: determinants of pregnant women's decisions regarding participation in a future Q fever screening and treatment program during a large epidemic in The Netherlands. (21717482)
2011
21
Q fever in Woolsorters, Belgium. (22172399)
2011
22
Abducens palsy complicating acute Q fever with review of the literature. (21474235)
2011
23
A Q fever case mimicking crimean-congo haemorrhagic fever. (22120806)
2011
24
Q fever endocarditis in Romania: the first cases confirmed by direct sequencing. (22272146)
2011
25
Q fever endocarditis in Spain. Clinical characteristics and outcome. (21333397)
2011
26
Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia. (21499708)
2011
27
Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat. (21680021)
2011
28
Disseminated intravascular coagulation as the laboratory hallmark of acute Q fever. (21251568)
2011
29
Preventing Q fever endocarditis: a review of cardiac assessment in hospitalised Q fever patients. (22115319)
2011
30
Q fever (Coxiella burnetii) causing an infected thoracoabdominal aortic aneurysm. (21276689)
2011
31
Difficulties in the diagnosis and management of a US servicemember presenting with possible chronic Q fever. (19766138)
2010
32
Diagnosis of acute Q fever with emphasis on enzyme-linked immunosorbent assay and nested polymerase chain reaction regarding the time of serum collection. (20846582)
2010
33
Q fever: a case with a vascular infection complication. (22767654)
2010
34
Central nervous system manifestations of Q fever responsive to steroids. (19743743)
2009
35
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
36
Q fever: epidemiology, diagnosis, and treatment. (18452690)
2008
37
Acute Q fever in southern Taiwan: atypical manifestations of hyperbilirubinemia and prolonged fever. (17949935)
2008
38
Acute Q fever in children presenting with encephalitis. (18054692)
2008
39
Diagnosis of acute Q fever by PCR on sera during a recent outbreak in rural south Australia. (17114779)
2006
40
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
41
Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10. (16826485)
2006
42
Q fever. (16503466)
2006
43
Q Fever Presenting As Recurrent, Culture-negative Endocarditis with Aortic Prosthetic Valve Failure: A Case Report and Review of the Literature. (18382649)
2006
44
Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons. (16547017)
2006
45
Q Fever pneumonia: are clarithromycin and moxifloxacin alternative treatments only? (16282309)
2005
46
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
47
Chronic Q fever associated with granulomatous hepatitis. (6699415)
1984
48
Serologic investigations in narcotic addicts. I. Syphilis, lymphogranuloma venereum, herpes simplex, and Q fever. (5682247)
1968
49
Q fever associated with granulomatous hepatitis. (13735411)
1960
50
Rickettsialpox and Q fever. (14772199)
1950

Variations for Q Fever

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Expression for genes affiliated with Q Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Q Fever

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Pathways for genes affiliated with Q Fever

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Q Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ARG1, CD40LG

Compounds for genes affiliated with Q Fever

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR
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Compounds related to Q Fever according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1tuberculin459.9MBL2, CD40LG
2mannan459.9CD40LG, MBL2
3cardiolipin45 1110.8CD40LG, MBL2
4anti-fungal459.8CD40LG, MBL2
5ribavirin45 51 1111.8MBL2, CD40LG
6lactose45 1110.8MBL2, CD40LG
7neopterin459.8CD40LG, MBL2
8carbohydrates459.7MBL2, CD40LG
9thyroxine45 2410.7CD40LG, MBL2
10endotoxin459.6CD40LG, ARG1
11mannose459.6SLC11A1, MBL2
12manganese45 2410.5ARG1, SLC11A1
13phosphatidylserine45 29 1111.4CD40LG, MBL2
14valine459.4ARG1, MBL2
15hydrogen45 2410.3MBL2, SLC11A1, ARG1
16rantes459.2CD40LG, MBL2
17vegf459.2MBL2, CD40LG, ARG1
18nitric oxide45 24 1111.2ARG1, SLC11A1, MBL2
19aspartate458.9ARG1, SLC11A1, CD40LG, MBL2

GO Terms for genes affiliated with Q Fever

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16Gene Ontology
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Cellular components related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0ARG1, CD40LG, MBL2

Biological processes related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.5SLC11A1, MBL2
2positive regulation of phagocytosisGO:0507669.2SLC11A1, MBL2

Products for genes affiliated with Q Fever

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  • Antibodies
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  • Antibodies

Sources for Q Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet