MCID: QFV001
MIFTS: 49

Q Fever malady

Genetic diseases, Rare diseases, Infectious diseases categories

Summaries for Q Fever

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CDC:3 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards based summary: Q Fever, also known as infection due to coxiella burnetii, is related to pneumonia and malaria, and has symptoms including fever, headache and cough. An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways is IL4-mediated signaling events. The compounds tuberculin and mannan have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and monocytes, and related mouse phenotypes are renal/urinary system and immune system.

Disease Ontology:9 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:63 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Q Fever, Aliases & Descriptions:

Name: Q Fever 9 41 11 47 3 60
Infection Due to Coxiella Burnetii 9 41 47
Quadrilateral Fever 41 47 60
Nine Mile Fever 41 47
Coxiellosis 41 47
 
Query Fever 41 47
Coxiella Burnetii Fever 41
Pneumonia in Q Fever 60
Q Fever Pneumonia 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
q fever:
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:11100
MeSH33 D011778
ICD9CM27 083.0
NCIt38 C34970
Orphanet47 781
MESH via Orphanet34 D011778
ICD10 via Orphanet26 A78
UMLS via Orphanet61 C0034362
ICD1025 A78

Related Diseases for Q Fever

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Diseases in the Q Fever family:

Recurrent Fever Multi-Gene Panels

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.0ARG1, MBL2
2malaria30.3SLC11A1
3glomerulonephritis30.2CD40LG, MBL2
4tuberculosis30.1SLC11A1, MBL2
5hepatitis c30.1ARG1, CD40LG
6endocarditis10.9
7hepatitis10.7
8typhus10.6
9brucellosis10.5
10granulomatous hepatitis10.5
11spotted fever10.5
12scrub typhus10.4
13cholecystitis10.4
14tularemia10.4
15cryptosporidiosis10.4MBL2
16leptospirosis10.4
17osteomyelitis10.4
18acalculous cholecystitis10.3
19uveitis10.3
20aneurysm10.3
21immunoglobulin g deficiency10.2MBL2, CD40LG
22immunoglobulin alpha deficiency10.2CD40LG, MBL2
23arthritis10.2
24cryoglobulinemia10.2
25splenic infarction10.2
26rickettsialpox10.2
27lymphogranuloma venereum10.2
28influenza10.2
29myocarditis10.2
30neuritis10.2
31optic neuritis10.2
32panniculitis10.2
33peritonitis10.2
34thrombophlebitis10.2
35mediterranean spotted fever10.2
36common variable immunodeficiency10.2CD40LG, MBL2
37pregnancy loss, recurrent 110.2MBL2, CD40LG
38autoimmune hepatitis10.2ARG1, CD40LG
39lupus nephritis10.2CD40LG, MBL2
40pulmonary tuberculosis10.2SLC11A1, MBL2
41iga glomerulonephritis10.2CD40LG, MBL2
42primary biliary cirrhosis10.1MBL2, CD40LG
43vasculitis10.1CD40LG, MBL2
44cork-handlers' disease10.1MBL2, SLC11A1
45systemic lupus erythematosus10.1
46prostate cancer10.1
47crohn's disease10.1
48hemolytic anemia10.1
49hepatitis b10.1
50leukemia10.1

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Symptoms for Q Fever

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Symptoms:

 9
  • fever
  • headache
  • cough
  • pleuritic chest pain
  • myalgia
  • arthralgia

Drugs & Therapeutics for Q Fever

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Drug clinical trials:

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Genetic Tests for Q Fever

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Anatomical Context for Q Fever

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MalaCards organs/tissues related to Q Fever:

31
Placenta, Testes, Monocytes, Bone marrow, Bone, Thyroid, Prostate, T cells, Endothelial

Animal Models for Q Fever or affiliated genes

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MGI Mouse Phenotypes related to Q Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7MBL2, CD40LG, PER2
2MP:00053878.3ARG1, MBL2, CD40LG, SLC11A1
3MP:00053977.6PER2, MBL2, CD40LG, SLC11A1, ARG1

Publications for Q Fever

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Articles related to Q Fever:

(show top 50)    (show all 573)
idTitleAuthorsYear
1
Acute Q fever and the risk of developing endocarditis. (25743166)
2015
2
A Probably Minor Role for Land-Applied Goat Manure in the Transmission of Coxiella burnetii to Humans in the 2007-2010 Dutch Q Fever Outbreak. (25816149)
2015
3
Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever. (25909712)
2015
4
Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever. (25356361)
2014
5
Serology in chronic Q fever is still surrounded by question marks. (24430618)
2014
6
Q Fever Reporting: Tip of the Iceberg? (25404072)
2014
7
Spatial relationships in the Q fever outbreaks 2007-2010 in the Netherlands. (23802588)
2014
8
Prevalence and risk factors for Coxiella burnetii (Q fever) in Dutch dairy cattle herds based on bulk tank milk testing. (25239684)
2014
9
Lookback procedures after postdonation notifications during a Q fever outbreak in the Netherlands. (22803955)
2013
10
Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin. (23293205)
2013
11
Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. (24252152)
2013
12
Recent progress in glycomics and proteomics of the Q fever bacterium Coxiella burnetii. (23600879)
2013
13
The impact of Q fever-phase-specific milk serology for the diagnosis of puerperal and chronic milk shedding of C. burnetii in dairy cows. (24199386)
2013
14
Culture negative prosthetic valve endocarditis in chronic Q fever: an under-recognized entity. (23642595)
2013
15
Epidemiological characteristics of serologically confirmed q Fever cases in South Korea, 2006-2011. (24159527)
2013
16
Self-reported sick leave and long-term health symptoms of Q-fever patients. (22315459)
2012
17
Q fever: new insights, still many queries. (22297098)
2012
18
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
19
Influence of the environment and occupational exposure on the occurrence of Q fever. (23285522)
2012
20
Identification of risk factors for chronic Q fever, the Netherlands. (22469535)
2012
21
Q fever as a cause of recurrent soft-tissue nodules and abscesses in a child. (22209918)
2012
22
Q Fever: an old but still a poorly understood disease. (23213331)
2012
23
Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands. (21784920)
2011
24
In search of hidden Q-fever outbreaks: linking syndromic hospital clusters to infected goat farms. (20478085)
2011
25
Risks, trust and knowledge: determinants of pregnant women's decisions regarding participation in a future Q fever screening and treatment program during a large epidemic in The Netherlands. (21717482)
2011
26
Q fever in Woolsorters, Belgium. (22172399)
2011
27
Abducens palsy complicating acute Q fever with review of the literature. (21474235)
2011
28
A Q fever case mimicking crimean-congo haemorrhagic fever. (22120806)
2011
29
Q fever endocarditis in Romania: the first cases confirmed by direct sequencing. (22272146)
2011
30
Q fever endocarditis in Spain. Clinical characteristics and outcome. (21333397)
2011
31
Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia. (21499708)
2011
32
Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat. (21680021)
2011
33
Disseminated intravascular coagulation as the laboratory hallmark of acute Q fever. (21251568)
2011
34
Difficulties in the diagnosis and management of a US servicemember presenting with possible chronic Q fever. (19766138)
2010
35
Diagnosis of acute Q fever with emphasis on enzyme-linked immunosorbent assay and nested polymerase chain reaction regarding the time of serum collection. (20846582)
2010
36
Central nervous system manifestations of Q fever responsive to steroids. (19743743)
2009
37
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
38
Q fever: epidemiology, diagnosis, and treatment. (18452690)
2008
39
Acute Q fever in southern Taiwan: atypical manifestations of hyperbilirubinemia and prolonged fever. (17949935)
2008
40
Acute Q fever in children presenting with encephalitis. (18054692)
2008
41
Diagnosis of acute Q fever by PCR on sera during a recent outbreak in rural south Australia. (17114779)
2006
42
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
43
Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10. (16826485)
2006
44
Q fever. (16503466)
2006
45
Q Fever Presenting As Recurrent, Culture-negative Endocarditis with Aortic Prosthetic Valve Failure: A Case Report and Review of the Literature. (18382649)
2006
46
Q Fever pneumonia: are clarithromycin and moxifloxacin alternative treatments only? (16282309)
2005
47
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
48
Chronic Q fever associated with granulomatous hepatitis. (6699415)
1984
49
Serologic investigations in narcotic addicts. I. Syphilis, lymphogranuloma venereum, herpes simplex, and Q fever. (5682247)
1968
50
Q fever associated with granulomatous hepatitis. (13735411)
1960

Variations for Q Fever

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Expression for genes affiliated with Q Fever

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Search GEO for disease gene expression data for Q Fever.

Pathways for genes affiliated with Q Fever

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Pathways related to Q Fever according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ARG1, CD40LG

Compounds for genes affiliated with Q Fever

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Sources:
43Novoseek, 12DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR
See all sources

Compounds related to Q Fever according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1tuberculin439.9MBL2, CD40LG
2mannan439.9CD40LG, MBL2
3cardiolipin43 1210.8CD40LG, MBL2
4anti-fungal439.8CD40LG, MBL2
5ribavirin43 49 1211.8MBL2, CD40LG
6lactose43 1210.8MBL2, CD40LG
7neopterin439.8CD40LG, MBL2
8carbohydrates439.7MBL2, CD40LG
9thyroxine43 2410.7CD40LG, MBL2
10endotoxin439.6CD40LG, ARG1
11mannose439.6SLC11A1, MBL2
12manganese43 2410.5ARG1, SLC11A1
13phosphatidylserine43 28 1211.4CD40LG, MBL2
14valine439.4ARG1, MBL2
15hydrogen43 2410.3MBL2, SLC11A1, ARG1
16rantes439.2CD40LG, MBL2
17vegf439.2MBL2, CD40LG, ARG1
18nitric oxide43 24 1211.2ARG1, SLC11A1, MBL2
19aspartate438.9ARG1, SLC11A1, CD40LG, MBL2

GO Terms for genes affiliated with Q Fever

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Cellular components related to Q Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.0ARG1, CD40LG, MBL2

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:00427429.5SLC11A1, MBL2
2positive regulation of phagocytosisGO:00507669.2SLC11A1, MBL2

Products for genes affiliated with Q Fever

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Sources for Q Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet