MCID: QFV001
MIFTS: 62

Q Fever malady

Infectious diseases category

Summaries for Q Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards: Q Fever, also known as infection due to coxiella burnetii, is related to hepatitis and pneumonia, and has symptoms including arthralgia, myalgia and pleuritic chest pain. An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways are NF-kappa B signaling pathway and Amoebiasis. The compounds p003 and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and bone, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:63 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
q fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

q fever 8 42 10 48 60
infection due to coxiella burnetii 8 48
query fever 42 48
coxiella burnetii fever 42
pneumonia in q fever 60
quadrilateral fever 48
q fever pneumonia 42
nine mile fever 48
coxiellosis 48


External Ids:

Disease Ontology8 DOID:11100
NCIt39 C34970
MeSH34 D011778
ICD9CM27 083.0
MESH via Orphanet35 D011778
ICD10 via Orphanet26 A78
SNOMED-CT via Orphanet57 186788009, 68981009
UMLS via Orphanet61 C0034362
ICD1025 A78

Related Diseases for Q Fever

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17GeneCards, 18GeneDecks
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Diseases in the Q Fever family:

Recurrent Fever Multi-Gene Panels

Diseases related to Q Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.9SELL, GPT, CD40LG
2pneumonia30.8MBL2, ARG1, SELL
3brucellosis30.7SLC11A1
4cholecystitis30.6GPT
5scrub typhus30.5GPT, CD40LG
6leptospirosis30.4CD40LG
7uveitis30.3CD14, IL1R1
8cryoglobulinemia30.2APOH, CD40LG
9hepatitis c30.2GPT, IL1R1, CD40LG, ARG1
10influenza30.2ADA, MBL2
11arthritis30.2IL1RN, IL1R1, SLC11A1, SELE
12malaria30.0SLC11A1
13disseminated intravascular coagulation30.0CD14
14lupus erythematosus30.0CD40LG, APOH
15prostate cancer30.0IL1R1
16thyroiditis30.0MBL2
17peritonitis30.0ADA, CD14
18hepatitis b30.0MBL2, GPT
19viral hepatitis30.0CD14, GPT
20antiphospholipid syndrome30.0APOH, CD40LG, SELE
21tuberculosis30.0MBL2, SLC11A1, SELL, ADA
22glomerulonephritis30.0MBL2, CD40LG, IL1RN, IL1R1
23lymphopenia30.0ADA, SELL, IL1RN
24systemic lupus erythematosus30.0MBL2, APOH, CD40LG, IL1RN, IL1R1, SELE
25endocarditis10.8
26typhus10.5
27spotted fever10.5
28granulomatous hepatitis10.4
29hepatitis a10.4
30chronic fatigue syndrome10.3
31tularemia10.3
32acalculous cholecystitis10.2
33osteomyelitis10.2
34rickettsialpox10.2
35splenic infarction10.2
36lymphogranuloma venereum10.2
37aortic aneurysm10.2
38myocarditis10.2
39neuritis10.2
40optic neuritis10.2
41panniculitis10.2
42relapsing fever10.2
43thrombophlebitis10.2
44acute thyroiditis10.0
45plasmodium malariae malaria10.0
46crohn's disease10.0
47pyuria10.0
48mononeuritis multiplex10.0
49campylobacteriosis10.0
50miller fisher syndrome10.0

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Clinical Features for Q Fever

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8Disease Ontology
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Symptoms:

8
  • arthralgia
  • myalgia
  • pleuritic chest pain
  • cough
  • headache
  • fever

Drugs & Therapeutics for Q Fever

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Q Fever

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Anatomical Context for Q Fever

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32MalaCards
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MalaCards organs/tissues related to Q Fever:

32
Placenta, Testes, Bone, Monocytes, Bone marrow, T cells, Prostate, Thyroid, Endothelial

Animal Models for Q Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Q Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.2TSFM, PER2, SELE, SLC11A1, IL1R1, IL1RN
2MP:00053979.2MBL2, PER2, SELE, SELL, SLC11A1, ADA
3MP:00053879.1CD14, CD40LG, ARG1, MBL2, IL1RN, IL1R1
4MP:00053768.8CD40LG, NUPR1, ARG1, APOH, IL1RN, IL1R1

Publications for Q Fever

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50PubMed
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Articles related to Q Fever:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Epidemiological characteristics of serologically confirmed q Fever cases in South Korea, 2006-2011. (24159527)
2013
2
A seroepidemiological survey of Q fever among sheep in Mazandaran province, northern Iran. (24364439)
2013
3
Persistence of DNA in a cured patient and positive culture in cases with low antibody levels bring into question diagnosis of Q fever endocarditis. (23850956)
2013
4
Investigating Coxiella burnetii infection in a breeding cattery at the centre of a Q fever outbreak. (23651605)
2013
5
Acute monoarthritis as presenting manifestation of acute Q fever: report of a new case and literature review. (23558160)
2013
6
Q fever in pregnant goats: humoral and cellular immune responses. (23915213)
2013
7
Psychosis Likely Induced by Hydroxychloroquine in a Patient With Chronic Q Fever: A Case Report and Clinically Relevant Review of Pharmacology. (24268495)
2013
8
Could it be Q fever? (23330744)
2013
9
Q fever: new insights, still many queries. (22297098)
2012
10
Influence of the environment and occupational exposure on the occurrence of Q fever. (23285522)
2012
11
Development of a lipopolysaccharide-targeted peptide mimic vaccine against Q fever. (23053512)
2012
12
Defective monocyte dynamics in Q fever granuloma deficiency. (22351939)
2012
13
Q fever pneumonia in French Guiana: prevalence, risk factors, and prognostic score. (22441648)
2012
14
Defining chronic Q fever: a matter of debate. (22898388)
2012
15
Epidemic Q fever in humans in the Netherlands. (22711640)
2012
16
Assessing the long-term health impact of Q-fever in the Netherlands: a prospective cohort study started in 2007 on the largest documented Q-fever outbreak to date. (23110336)
2012
17
Shifting priorities in the aftermath of a Q fever epidemic in 2007 to 2009 in The Netherlands: from acute to chronic infection. (22297101)
2012
18
Molecular typing of Coxiella burnetii from animal and environmental matrices during Q fever epidemics in the Netherlands. (22988998)
2012
19
The health status of Q-fever patients after long-term follow-up. (21501483)
2011
20
Seroprevalence of Q fever in naturally infected dairy cattle herds. (21645936)
2011
21
Coxiella burnetii infection in roe deer during Q fever epidemic, the Netherlands. (22172398)
2011
22
Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting. (21508172)
2011
23
Q fever outbreak in a small village, Taiwan. (20495278)
2010
24
Q fever serology in febrile patients in southeast Iran. (20627331)
2010
25
First case of Q fever endocarditis in Croatia and a short review. (20977118)
2010
26
A large Q fever outbreak in an urban school in central Israel. (20415568)
2010
27
Central nervous system manifestations of Q fever responsive to steroids. (19743743)
2009
28
Reemergence of Q fever after 11 September 2001. (19191639)
2009
29
Ovine-associated Q fever. (18840318)
2009
30
Determination of new cutoff values for indirect immunofluorescence antibody test for Q fever diagnosis in Denmark. (19748417)
2009
31
Three years experience of real-time PCR for the diagnosis of Q fever. (19438615)
2009
32
Q fever in Dalmatia, Croatia. (19438627)
2009
33
Serological and molecular characterization of AdaA: a potential marker of Q-fever abortion in goats? (19281458)
2009
34
An update on a serologic survey of Q Fever in domestic animals in Iran. (19478271)
2009
35
Acute Q fever in children presenting with encephalitis. (18054692)
2008
36
Q fever endocarditis: the Mayo Clinic experience. (18626237)
2008
37
Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray. (18845831)
2008
38
"The dust hasn't settled yet": the National Q fever Management Program, missed opportunities for vaccination and community exposures. (17725010)
2007
39
Q fever community-acquired pneumonia in a patient with Crohn's disease on immunosuppressive therapy. (17628200)
2007
40
Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever. (17855803)
2007
41
Q fever cases at a North Queensland centre during 1994-2006. (17714204)
2007
42
Q fever (Coxiella burnetii) among man and farm animals in North Sinai, Egypt. (17580573)
2007
43
Case-control study for risk factors for Q fever in southwest England and Northern Ireland. (17130654)
2006
44
Active surveillance of Q fever in human and animal population of Cyprus. (16539741)
2006
45
Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis. (16280092)
2005
46
Identification, cloning, and expression of potential diagnostic markers for Q fever. (16481493)
2005
47
Thrombophlebitis in a patient with acute Q fever and anticardiolipin antibodies]. (9139149)
1997
48
Seroepidemiologic study of three zoonoses (leptospirosis, Q fever, and tularemia) among trappers in QuAcbec, Canada. (7583933)
1995
49
Further serological investigations in humans and domestic animals on the Cape Verde Islands (Q-fever, brucellosis, listeriosis, shigellosis, campylobacteriosis, yersiniosis, toxoplasmosis and chlamydia of PLT-group). (3139491)
1988
50
Chronic Q fever associated with granulomatous hepatitis. (6699415)
1984

Genetic Variations for Q Fever

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Expression for genes affiliated with Q Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for genes affiliated with Q Fever

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Q Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL1R1, CD14, CD40LG
210.1IL1R1, CD14, ARG1
3
Immune response Bacterial infections in normal airways
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10.1IL1R1, IL1RN, CD14

Compounds for genes affiliated with Q Fever

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Q Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1p0034410.7APOH
2phosphatidylserine44 28 1112.6APOH, CD14
3glucuronoxylomannan4410.5CD14, SELL, CD40LG
4slea4410.5SELL, SELE, CD40LG
5endotoxin4410.5APOH, ARG1, SELL, SELE
6dextran sulfate4410.5CD40LG, SELL, APOH
7tuberculin4410.4MBL2, ADA, CD40LG, CD14
8cuprophan4410.4SELL, CD14, IL1RN, IL1R1
9polysulfone4410.4SELL, IL1R1, IL1RN, CD14
10gold sodium thiomalate4410.4IL1R1, SELE, IL1RN, CD14
11sulfasalazine44 28 49 1113.4IL1R1, IL1RN, CD40LG, SELE
12polymyxin b4410.4MBL2, SELE, CD14, IL1RN
13hydroxychloroquine44 1111.4CD40LG, APOH, IL1R1
14rantes4410.4CD14, SELL, CD40LG, MBL2, IL1R1
15prednisolone44 28 1112.3IL1R1, APOH, CD14, MBL2, SELL
16lactose44 1111.3CD40LG, SELL, MBL2, SELE
17peptidoglycan44 2811.3IL1R1, MBL2, CD14, IL1RN
18infliximab44 49 1112.3IL1R1, SELE, APOH, IL1RN
19ivig4410.3IL1RN, CD40LG, APOH, IL1R1, GPT
20ribavirin44 49 1112.3GPT, MBL2, ADA, CD40LG
21polyethylene glycol4410.3ADA, SELE, CD40LG, IL1RN, IL1R1
22atorvastatin44 49 28 11 2414.3SELL, SELE, GPT, IL1RN, CD40LG
23pentoxifylline44 1111.3CD14, SELL, IL1R1, IL1RN
24mannose4410.2IL1RN, MBL2, APOH, CD14, SLC11A1
25carbohydrates4410.2SELE, CD14, IL1RN, CD40LG, MBL2, SELL
26lipoteichoic acid4410.2IL1R1, CD14, SELE, MBL2, APOH, IL1RN
27vitamin b124410.2CD40LG, APOH, GPT, ADA
28epinephrine44 11 2412.2SELL, IL1R1, IL1RN, SELE, CD40LG, ADA
29vitamin d4410.1IL1R1, IL1RN, MBL2, GPT, SLC11A1, CD14
30methotrexate44 49 1112.1IL1RN, ADA, APOH, GPT, IL1R1, SELE
31pge14410.1SELL, GPT, APOH, IL1RN
32amphotericin b4410.1ADA, IL1R1, IL1RN
33histamine44 28 2412.1IL1RN, CD14, ADA, SELE, CD40LG, SELL
34neopterin4410.1ADA, MBL2, CD40LG, CD14, IL1RN, IL1R1
35aspirin44 49 28 2413.1ADA, IL1R1, APOH, CD40LG, IL1RN, SELL
36aspartate4410.1SLC11A1, GPT, CD14, CD40LG, MBL2, SELE
37indomethacin44 59 28 1113.1IL1R1
38heparin44 28 11 2413.0SELL, SELE, APOH, IL1RN, CD14, CD40LG
39latex4410.0CD14, IL1RN, APOH, MBL2
40fibrinogen4410.0IL1R1, APOH, SELE, GPT, IL1RN, CD40LG
41cyclosporin a44 28 5911.9CD14, IL1RN, ADA, GPT, IL1R1, CD40LG
42cholesterol44 28 11 2412.9IL1R1, IL1RN, CD14, GPT, SELE, APOH
43alanine449.9CD14, CD40LG, ADA, GPT, IL1RN, SELL
44glutamate449.8ADA, LNX1, GPT, IL1RN, IL1R1, CD40LG
45lactate449.8IL1RN, APOH, CD40LG, CD14, ADA, SELE
46dexamethasone44 49 28 1112.8CD40LG, CD14, MBL2, IL1RN, ADA, IL1R1
47vegf449.8CD14, APOH, SELL, IL1R1, IL1RN, MBL2
48creatinine449.7ADA, SELE, SELL, GPT, IL1R1, MBL2
49arginine449.7GPT, ADA, APOH, ARG1, CD40LG, CD14
50nitric oxide44 11 2411.6SLC11A1, IL1RN, SELE, ARG1, APOH, MBL2

GO Terms for genes affiliated with Q Fever

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16Gene Ontology
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Cellular components related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.9ADA, IL1R1, CD14, APOH, MBL2
2extracellular spaceGO:0056159.2ADA, MBL2, APOH, ARG1, CD40LG, CD14

Biological processes related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.9SELE, SLC11A1, NMI, CD14, CD40LG

Products for genes affiliated with Q Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Q Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet