MCID: QFV001
MIFTS: 58

Q Fever malady

Genetic diseases, Rare diseases, Infectious diseases categories
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Summaries for Q Fever

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CDC:3 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards based summary: Q Fever, also known as infection due to coxiella burnetii, is related to pneumonia and malaria, and has symptoms including An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways is IL4-mediated signaling events. The compounds tuberculin and mannan have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and monocytes, and related mouse phenotypes are renal/urinary system and immune system.

Disease Ontology:8 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:65 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Q Fever, Aliases & Descriptions:

Name: Q Fever 8 42 10 48 62
Infection Due to Coxiella Burnetii 8 48 62
Query Fever 42 48 62
Coxiella Burnetii Fever 42 62
Quadrilateral Fever 48 62
 
Pneumonia in Q Fever 62
Q Fever Pneumonia 42
Fever, Nine Mile 62
Nine Mile Fever 48
Coxiellosis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
q fever:
Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:11100
ICD9CM27 083.0
NCIt39 C34970
MeSH34 D011778
MESH via Orphanet35 D011778
ICD10 via Orphanet26 A78
UMLS via Orphanet63 C0034362
ICD1025 A78

Related Diseases for Q Fever

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Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Symptoms for Q Fever

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Drugs & Therapeutics for Q Fever

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Drug clinical trials:

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Genetic Tests for Q Fever

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Anatomical Context for Q Fever

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MalaCards organs/tissues related to Q Fever:

32
Placenta, Testes, Monocytes, Bone marrow, Bone, Thyroid, Prostate, T cells, Endothelial

Animal Models for Q Fever or affiliated genes

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MGI Mouse Phenotypes related to Q Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7CD40LG, MBL2, PER2
2MP:00053878.3MBL2, CD40LG, SLC11A1, ARG1
3MP:00053977.6ARG1, SLC11A1, CD40LG, MBL2, PER2

Publications for Q Fever

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Articles related to Q Fever:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever. (25356361)
2014
2
Serology in chronic Q fever is still surrounded by question marks. (24430618)
2014
3
Q Fever Reporting: Tip of the Iceberg? (25404072)
2014
4
Spatial relationships in the Q fever outbreaks 2007-2010 in the Netherlands. (23802588)
2014
5
Prevalence and risk factors for Coxiella burnetii (Q fever) in Dutch dairy cattle herds based on bulk tank milk testing. (25239684)
2014
6
Lookback procedures after postdonation notifications during a Q fever outbreak in the Netherlands. (22803955)
2013
7
Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin. (23293205)
2013
8
Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. (24252152)
2013
9
Recent progress in glycomics and proteomics of the Q fever bacterium Coxiella burnetii. (23600879)
2013
10
The impact of Q fever-phase-specific milk serology for the diagnosis of puerperal and chronic milk shedding of C. burnetii in dairy cows. (24199386)
2013
11
Culture negative prosthetic valve endocarditis in chronic Q fever: an under-recognized entity. (23642595)
2013
12
Epidemiological characteristics of serologically confirmed q Fever cases in South Korea, 2006-2011. (24159527)
2013
13
Self-reported sick leave and long-term health symptoms of Q-fever patients. (22315459)
2012
14
Q fever: new insights, still many queries. (22297098)
2012
15
Coxiella burnetii endocarditis after Q fever vaccination. (22956746)
2012
16
Influence of the environment and occupational exposure on the occurrence of Q fever. (23285522)
2012
17
Identification of risk factors for chronic Q fever, the Netherlands. (22469535)
2012
18
Q fever as a cause of recurrent soft-tissue nodules and abscesses in a child. (22209918)
2012
19
Q Fever: an old but still a poorly understood disease. (23213331)
2012
20
Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands. (21784920)
2011
21
In search of hidden Q-fever outbreaks: linking syndromic hospital clusters to infected goat farms. (20478085)
2011
22
Risks, trust and knowledge: determinants of pregnant women's decisions regarding participation in a future Q fever screening and treatment program during a large epidemic in The Netherlands. (21717482)
2011
23
Q fever in Woolsorters, Belgium. (22172399)
2011
24
Abducens palsy complicating acute Q fever with review of the literature. (21474235)
2011
25
A Q fever case mimicking crimean-congo haemorrhagic fever. (22120806)
2011
26
Q fever endocarditis in Romania: the first cases confirmed by direct sequencing. (22272146)
2011
27
Q fever endocarditis in Spain. Clinical characteristics and outcome. (21333397)
2011
28
Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia. (21499708)
2011
29
Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat. (21680021)
2011
30
Disseminated intravascular coagulation as the laboratory hallmark of acute Q fever. (21251568)
2011
31
Preventing Q fever endocarditis: a review of cardiac assessment in hospitalised Q fever patients. (22115319)
2011
32
Difficulties in the diagnosis and management of a US servicemember presenting with possible chronic Q fever. (19766138)
2010
33
Diagnosis of acute Q fever with emphasis on enzyme-linked immunosorbent assay and nested polymerase chain reaction regarding the time of serum collection. (20846582)
2010
34
Q fever: a case with a vascular infection complication. (22767654)
2010
35
Central nervous system manifestations of Q fever responsive to steroids. (19743743)
2009
36
Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. (18797945)
2009
37
Q fever: epidemiology, diagnosis, and treatment. (18452690)
2008
38
Acute Q fever in southern Taiwan: atypical manifestations of hyperbilirubinemia and prolonged fever. (17949935)
2008
39
Acute Q fever in children presenting with encephalitis. (18054692)
2008
40
Diagnosis of acute Q fever by PCR on sera during a recent outbreak in rural south Australia. (17114779)
2006
41
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
42
Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10. (16826485)
2006
43
Q fever. (16503466)
2006
44
Q Fever Presenting As Recurrent, Culture-negative Endocarditis with Aortic Prosthetic Valve Failure: A Case Report and Review of the Literature. (18382649)
2006
45
Q Fever pneumonia: are clarithromycin and moxifloxacin alternative treatments only? (16282309)
2005
46
The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis. (10931145)
2000
47
Chronic Q fever associated with granulomatous hepatitis. (6699415)
1984
48
Serologic investigations in narcotic addicts. I. Syphilis, lymphogranuloma venereum, herpes simplex, and Q fever. (5682247)
1968
49
Q fever associated with granulomatous hepatitis. (13735411)
1960
50
Rickettsialpox and Q fever. (14772199)
1950

Variations for Q Fever

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Expression for genes affiliated with Q Fever

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Expression patterns in normal tissues for genes affiliated with Q Fever

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Pathways for genes affiliated with Q Fever

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Pathways related to Q Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ARG1, CD40LG

Compounds for genes affiliated with Q Fever

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 28IUPHAR
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Compounds related to Q Fever according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1tuberculin449.9MBL2, CD40LG
2mannan449.9CD40LG, MBL2
3cardiolipin44 1110.8CD40LG, MBL2
4anti-fungal449.8CD40LG, MBL2
5ribavirin44 50 1111.8MBL2, CD40LG
6lactose44 1110.8MBL2, CD40LG
7neopterin449.8CD40LG, MBL2
8carbohydrates449.7MBL2, CD40LG
9thyroxine44 2410.7CD40LG, MBL2
10endotoxin449.6CD40LG, ARG1
11mannose449.6SLC11A1, MBL2
12manganese44 2410.5ARG1, SLC11A1
13phosphatidylserine44 28 1111.4CD40LG, MBL2
14valine449.4ARG1, MBL2
15hydrogen44 2410.3MBL2, SLC11A1, ARG1
16rantes449.2CD40LG, MBL2
17vegf449.2MBL2, CD40LG, ARG1
18nitric oxide44 24 1111.2ARG1, SLC11A1, MBL2
19aspartate448.9ARG1, SLC11A1, CD40LG, MBL2

GO Terms for genes affiliated with Q Fever

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Cellular components related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0ARG1, CD40LG, MBL2

Biological processes related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.5SLC11A1, MBL2
2positive regulation of phagocytosisGO:0507669.2SLC11A1, MBL2

Products for genes affiliated with Q Fever

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Sources for Q Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet