MCID: QFV001
MIFTS: 62

Q Fever malady

Infectious diseases category

Summaries for Q Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in milk, urine, and feces of infected animals. During birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organism is extremely hardy and resistant to heat, drying, and many common disinfectants which enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

MalaCards: Q Fever, also known as infection due to coxiella burnetii, is related to hepatitis and pneumonia, and has symptoms including arthralgia, myalgia and pleuritic chest pain. An important gene associated with Q Fever is CD40LG (CD40 ligand), and among its related pathways are NF-kappa B signaling pathway and Amoebiasis. The compounds p003 and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and bone, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. the infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia:63 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Aliases & Classifications for Q Fever

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
q fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

q fever 8 42 10 48 60
infection due to coxiella burnetii 8 48
query fever 42 48
coxiella burnetii fever 42
pneumonia in q fever 60
quadrilateral fever 48
q fever pneumonia 42
nine mile fever 48
coxiellosis 48


External Ids:

Disease Ontology8 DOID:11100
NCIt39 C34970
MeSH34 D011778
ICD9CM27 083.0
MESH via Orphanet35 D011778
ICD10 via Orphanet26 A78
SNOMED-CT via Orphanet57 186788009, 68981009
UMLS via Orphanet61 C0034362
ICD1025 A78

Related Diseases for Q Fever

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17GeneCards, 18GeneDecks
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Diseases in the Q Fever family:

Recurrent Fever Multi-Gene Panels

Diseases related to Q Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.9SELL, GPT, CD40LG
2pneumonia30.8MBL2, ARG1, SELL
3brucellosis30.7SLC11A1
4cholecystitis30.6GPT
5scrub typhus30.5GPT, CD40LG
6leptospirosis30.4CD40LG
7uveitis30.3CD14, IL1R1
8cryoglobulinemia30.2APOH, CD40LG
9hepatitis c30.2GPT, IL1R1, CD40LG, ARG1
10influenza30.2ADA, MBL2
11arthritis30.2IL1RN, IL1R1, SLC11A1, SELE
12malaria30.0SLC11A1
13disseminated intravascular coagulation30.0CD14
14lupus erythematosus30.0CD40LG, APOH
15prostate cancer30.0IL1R1
16thyroiditis30.0MBL2
17peritonitis30.0ADA, CD14
18hepatitis b30.0MBL2, GPT
19viral hepatitis30.0CD14, GPT
20antiphospholipid syndrome30.0APOH, CD40LG, SELE
21tuberculosis30.0MBL2, SLC11A1, SELL, ADA
22glomerulonephritis30.0MBL2, CD40LG, IL1RN, IL1R1
23lymphopenia30.0ADA, SELL, IL1RN
24systemic lupus erythematosus30.0MBL2, APOH, CD40LG, IL1RN, IL1R1, SELE
25endocarditis10.8
26typhus10.5
27spotted fever10.5
28granulomatous hepatitis10.4
29hepatitis a10.4
30chronic fatigue syndrome10.3
31tularemia10.3
32acalculous cholecystitis10.2
33osteomyelitis10.2
34rickettsialpox10.2
35splenic infarction10.2
36lymphogranuloma venereum10.2
37aortic aneurysm10.2
38myocarditis10.2
39neuritis10.2
40optic neuritis10.2
41panniculitis10.2
42relapsing fever10.2
43thrombophlebitis10.2
44acute thyroiditis10.0
45plasmodium malariae malaria10.0
46crohn's disease10.0
47pyuria10.0
48mononeuritis multiplex10.0
49campylobacteriosis10.0
50miller fisher syndrome10.0

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to q fever

Clinical Features for Q Fever

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8Disease Ontology
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Symptoms:

8
  • arthralgia
  • myalgia
  • pleuritic chest pain
  • cough
  • headache
  • fever

Drugs & Therapeutics for Q Fever

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Q Fever

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Anatomical Context for Q Fever

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32MalaCards
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MalaCards organs/tissues related to Q Fever:

32
Placenta, Testes, Bone, Monocytes, Bone marrow, T cells, Prostate, Thyroid, Endothelial

Animal Models for Q Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Q Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.2ARG1, CD40LG, CD14, IL1RN, IL1R1, SLC11A1
2MP:00053979.2ADA, MBL2, ARG1, CD40LG, IL1RN, IL1R1
3MP:00053879.1CD14, CD40LG, ARG1, MBL2, IL1RN, IL1R1
4MP:00053768.8CD40LG, NUPR1, ARG1, APOH, MBL2, CD14

Publications for Q Fever

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50PubMed
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Articles related to Q Fever:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Seroepidemiological survey of q Fever and brucellosis in kurdistan province, Western iran. (24359427)
2014
2
Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. (24252152)
2013
3
A Combination of IFN-I^ and IL-2 Production by Coxiella burnetii Stimulated Circulating Cells Discriminates Between Chronic Q Fever and Past Q Fever. (24118683)
2013
4
Demography of Q fever seroprevalence in sheep and goats in The Netherlands in 2008. (23031327)
2013
5
Q fever: a neglected zoonosis in Saudi Arabia. (24188940)
2013
6
A case of Q fever prosthetic joint infection and description of an assay for detection of Coxiella burnetii. (23077126)
2013
7
Microevolution of the chromosomal region of acute disease antigen A (adaA) in the query (Q) fever agent Coxiella burnetii. (23301072)
2013
8
Spatial analysis of positive and negative Q fever laboratory results for identifying high- and low-risk areas of infection in the Netherlands. (24298327)
2013
9
Coxiella burnetii in sewage water at sewage water treatment plants in a Q fever epidemic area. (23347968)
2013
10
The Qure study: Q fever fatigue syndrome--response to treatment; a randomized placebo-controlled trial. (23536997)
2013
11
Protein array of Coxiella burnetii probed with Q fever sera. (23633077)
2013
12
Q fever: baseline monitoring of a sheep and a goat flock associated with human infections. (22217267)
2012
13
Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis. (22607576)
2012
14
Visits on 'lamb-viewing days' at a sheep farm open to the public was a risk factor for Q fever in 2009. (21835066)
2012
15
Hypophosphatemia, fever and prolonged length of hospital stay in seronegative PCR positive patients as compared to seropositive patients with early acute Q fever pneumonia. (22868810)
2012
16
An analysis of Q fever patients 6 years after an outbreak in Newport, Wales, UK. (22771556)
2012
17
Screening-level risk assessment of Coxiella burnetii (Q fever) transmission via aeration of drinking water. (22309101)
2012
18
Detection of Coxiella burnetii DNA on small-ruminant farms during a Q fever outbreak in the Netherlands. (22247143)
2012
19
Q fever in Woolsorters, Belgium. (22172399)
2011
20
Disseminated intravascular coagulation as the laboratory hallmark of acute Q fever. (21251568)
2011
21
Preventing Q fever endocarditis: a review of cardiac assessment in hospitalised Q fever patients. (22115319)
2011
22
Q fever in Japan: an update review. (21146331)
2011
23
Coxiella burnetii (Q fever) in Rattus norvegicus and Rattus rattus at livestock farms and urban locations in the Netherlands; could Rattus spp. represent reservoirs for (re)introduction? (21640416)
2011
24
Use of a single-tube nested real-time PCR assay to facilitate the early diagnosis of acute Q fever. (21519134)
2011
25
Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in The Netherlands. (21314933)
2011
26
Investigation of a Q fever outbreak in a Scottish co-located slaughterhouse and cutting plant. (19912614)
2010
27
Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens. (20639288)
2010
28
Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study. (20802011)
2010
29
Q Fever. (19875249)
2010
30
A case of Q fever. (19626527)
2009
31
The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. (18977677)
2009
32
Epidemiology of acute q Fever, scrub typhus, and murine typhus, and identification of their clinical characteristics compared to patients with acute febrile illness in southern taiwan. (19443290)
2009
33
Molecular epidemiology of Q fever in Poland. (19469280)
2009
34
Q fever in young children, Ghana. (18258140)
2008
35
Persistent hepatitis and repeated wheezing in an infant. Q fever. (17848898)
2007
36
Goats may experience reproductive failures and shed Coxiella burnetii at two successive parturitions after a Q fever infection. (17187835)
2007
37
Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. (16477559)
2006
38
Chronic Q fever in the United States. (16757641)
2006
39
Q fever in members of the United States armed forces returning from Iraq. (16983603)
2006
40
Q fever endocarditis masquerading as Mixed cryoglobulinemia type II. A case report and review of the literature. (16504099)
2006
41
Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii. (16481504)
2005
42
Pulmonary disease from biological agents: anthrax, plague, Q fever, and tularemia. (16168313)
2005
43
Evaluation of low concentration aerosol for infecting humans with the Q fever pathogen. (16481561)
2005
44
Pulmonary manifestations of other agents: brucella, Q fever, tularemia and smallpox. (15062230)
2004
45
Migratory thrombophlebitis and acute Q fever. (15116709)
2004
46
Mononeuritis multiplex caused by Coxiella burnetii infection (Q fever). (12460144)
2002
47
Erythema nodosum and acute Q fever: report of a case with granulomatous hepatitis and immunological abnormalities. (9059687)
1997
48
Bone-marrow necrosis and Q fever. (7427604)
1980
49
Combined epidemic typhus and Q-fever vaccine: adjuvant effect of Coxiella burneti. (6042428)
1967
50
Q fever associated with granulomatous hepatitis. (13735411)
1960

Genetic Variations for Q Fever

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Expression for genes affiliated with Q Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for genes affiliated with Q Fever

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Q Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL1R1, CD14, CD40LG
210.1IL1R1, CD14, ARG1
3
Immune response Bacterial infections in normal airways
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10.1IL1R1, IL1RN, CD14

Compounds for genes affiliated with Q Fever

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Q Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1p0034410.7APOH
2phosphatidylserine44 28 1112.6APOH, CD14
3glucuronoxylomannan4410.5CD14, SELL, CD40LG
4slea4410.5SELL, SELE, CD40LG
5endotoxin4410.5APOH, ARG1, SELL, SELE
6dextran sulfate4410.5CD40LG, SELL, APOH
7tuberculin4410.4MBL2, ADA, CD40LG, CD14
8cuprophan4410.4SELL, CD14, IL1RN, IL1R1
9polysulfone4410.4SELL, IL1R1, IL1RN, CD14
10gold sodium thiomalate4410.4IL1R1, SELE, IL1RN, CD14
11sulfasalazine44 28 49 1113.4IL1R1, IL1RN, CD40LG, SELE
12polymyxin b4410.4MBL2, SELE, CD14, IL1RN
13hydroxychloroquine44 1111.4CD40LG, APOH, IL1R1
14rantes4410.4CD14, SELL, CD40LG, MBL2, IL1R1
15prednisolone44 28 1112.3IL1R1, APOH, CD14, MBL2, SELL
16lactose44 1111.3CD40LG, SELL, MBL2, SELE
17peptidoglycan44 2811.3IL1R1, MBL2, CD14, IL1RN
18infliximab44 49 1112.3IL1R1, SELE, APOH, IL1RN
19ivig4410.3IL1RN, CD40LG, APOH, IL1R1, GPT
20ribavirin44 49 1112.3GPT, MBL2, ADA, CD40LG
21polyethylene glycol4410.3ADA, SELE, CD40LG, IL1RN, IL1R1
22atorvastatin44 49 28 11 2414.3SELL, SELE, GPT, IL1RN, CD40LG
23pentoxifylline44 1111.3CD14, SELL, IL1R1, IL1RN
24mannose4410.2IL1RN, MBL2, APOH, CD14, SLC11A1
25carbohydrates4410.2SELE, CD14, IL1RN, CD40LG, MBL2, SELL
26lipoteichoic acid4410.2IL1R1, CD14, SELE, MBL2, APOH, IL1RN
27vitamin b124410.2CD40LG, APOH, GPT, ADA
28epinephrine44 11 2412.2SELL, IL1R1, IL1RN, SELE, CD40LG, ADA
29vitamin d4410.1IL1R1, IL1RN, MBL2, GPT, SLC11A1, CD14
30methotrexate44 49 1112.1IL1RN, ADA, APOH, GPT, IL1R1, SELE
31pge14410.1SELL, GPT, APOH, IL1RN
32amphotericin b4410.1ADA, IL1R1, IL1RN
33histamine44 28 2412.1IL1RN, CD14, ADA, SELE, CD40LG, SELL
34neopterin4410.1ADA, MBL2, CD40LG, CD14, IL1RN, IL1R1
35aspirin44 49 28 2413.1ADA, IL1R1, APOH, CD40LG, IL1RN, SELL
36aspartate4410.1SLC11A1, GPT, CD14, CD40LG, MBL2, SELE
37indomethacin44 59 28 1113.1IL1R1
38heparin44 28 11 2413.0SELL, SELE, APOH, IL1RN, CD14, CD40LG
39latex4410.0CD14, IL1RN, APOH, MBL2
40fibrinogen4410.0IL1R1, APOH, SELE, GPT, IL1RN, CD40LG
41cyclosporin a44 28 5911.9CD14, IL1RN, ADA, GPT, IL1R1, CD40LG
42cholesterol44 28 11 2412.9IL1R1, IL1RN, CD14, GPT, SELE, APOH
43alanine449.9CD14, CD40LG, ADA, GPT, IL1RN, SELL
44glutamate449.8ADA, LNX1, GPT, IL1RN, IL1R1, CD40LG
45lactate449.8IL1RN, APOH, CD40LG, CD14, ADA, SELE
46dexamethasone44 49 28 1112.8CD40LG, CD14, MBL2, IL1RN, ADA, IL1R1
47vegf449.8CD14, APOH, SELL, IL1R1, IL1RN, MBL2
48creatinine449.7ADA, SELE, SELL, GPT, IL1R1, MBL2
49arginine449.7GPT, ADA, APOH, ARG1, CD40LG, CD14
50nitric oxide44 11 2411.6SLC11A1, IL1RN, SELE, ARG1, APOH, MBL2

GO Terms for genes affiliated with Q Fever

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16Gene Ontology
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Cellular components related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.9ADA, IL1R1, CD14, APOH, MBL2
2extracellular spaceGO:0056159.2ADA, MBL2, APOH, ARG1, CD40LG, CD14

Biological processes related to Q Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.9SELE, SLC11A1, NMI, CD14, CD40LG

Products for genes affiliated with Q Fever

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  • Antibodies
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  • Lysates
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Sources for Q Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet