Quadriplegia malady

Wikipedia: Tetraplegia, also known as quadriplegia, is paralysis caused by illness or injury to a human that...⁴⁴ more...

MalaCards: Quadriplegia, also known as quadriplegia, unspecified, is related to spastic quadriplegia and spasticity. An important gene associated with Quadriplegia is PLP1 (proteolipid protein 1), and among its related pathways is Other glycan degradation. The compound l-fucose have been mentioned in the context of this disorder.

Aliases & Descriptions:

quadriplegia 6 8 43 quadriplegia, unspecified 6 quadriplegia (disorder) 6

tetraplegias 32 tetraplegia 6

Diseases related to quadriplegia by text searches and GeneDecks gene sharing:

(show all 23)

id	Related Disease	Score	Top Affiliating Genes
1	spastic quadriplegia	29.2	SPTAN1, KANK1, FUCA1, SDHA, SDHAF1, FUCA2
2	spasticity	26.6	ARG1, KANK1, SDHAF1, SDHA, AP4M1, ALDH3A2
3	mitochondrial complex ii deficiency	13.4	SDHA, SDHAF1
4	pelizaeus-merzbacher-like disease	13.4	PLP1, SLC16A2
5	kearns-sayre syndrome	13.2	SDHA, SDHAF1
6	nystagmus	13.2	KANK1, SLC16A2, PLP1
7	hypokalemic periodic paralysis	13.1	KCNE1L, KCNE4
8	hypotonia	12.9	KANK1, ARG1, AP4M1, SLC16A2
9	laryngotracheitis	12.9	FUCA1, FUCA2
10	spastic diplegia	12.9	ALDH3A2, ARG1
11	fucosidosis	12.8	FUCA1, FUCA2
12	spondylosis	12.6	IFIT1, COL6A1
13	cerebral palsy	12.5	ALDH3A2, AP4M1, KANK1, SDPR, PLP1
14	microcephaly with spastic quadriplegia	6.9
15	spastic monoplegia	6.9
16	spastic quadriplegia retinitis pigmentosa mental retardation	6.9
17	congenital ichthyosis, microcephalus, quadriplegia	6.4
18	cerebritis	5.4
19	ichthyosis	5.4
20	paralysis	5.4
21	paraplegia	5.4
22	pseudoprogeria syndrome	5.4
23	west syndrome	5.4

Approved drugs:

Drug clinical trials:

Articles related to quadriplegia:

id	Title	Authors	Year	Affiliating Genes
1	Recessive mutations in ELOVL4 cause ichthyosis, intel lectual disability, and spastic quadriplegia. (22100072)	Aldahmesh M.A.... Alkuraya F.S.	2011	TIAM1, ELOVL4, TBCC
2	Dominant-negative mutations in alpha-II spectrin caus e West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (20493457)	Saitsu H.... Matsumoto N.	2010	SPTAN1

Genes related to quadriplegia according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	PLP1	proteolipid protein 1	11.0
2	SDHAF1	succinate dehydrogenase complex assembly factor 1	11.0
3	ELOVL4	ELOVL fatty acid elongase 4	11.0	Publications
4	ARG1	arginase, liver	11.0
5	SLC16A2	solute carrier family 16, member 2 (thyroid hormone transporter)	11.0
6	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0
7	SPTAN1	spectrin, alpha, non-erythrocytic 1	11.0	Publications
8	KANK1	KN motif and ankyrin repeat domains 1	11.0
9	KCNE4	potassium voltage-gated channel, Isk-related family, member 4	11.0	Disorders
10	KCNE1L	KCNE1-like	11.0	Disorders
11	LIN37	lin-37 homolog (C. elegans)	11.0	Disorders
12	CDC42EP5	CDC42 effector protein (Rho GTPase binding) 5	11.0	Disorders
13	OR13G1	olfactory receptor, family 13, subfamily G, member 1	11.0	Disorders
14	MOCS2	molybdenum cofactor synthesis 2	11.0	Disorders
15	SDPR	serum deprivation response	11.0
16	CST7	cystatin F (leukocystatin)	11.0	Disorders
17	IFIT1	interferon-induced protein with tetratricopeptide repeats 1	11.0
18	AP4M1	adaptor-related protein complex 4, mu 1 subunit	11.0
19	IRAK1BP1	interleukin-1 receptor-associated kinase 1 binding protein 1	11.0	Disorders
20	FUCA2	fucosidase, alpha-L- 2, plasma	11.0	Disorders
21	ALDH3A2	aldehyde dehydrogenase 3 family, member A2	11.0
22	FUCA1	fucosidase, alpha-L- 1, tissue	11.0	Disorders
23	COL6A1	collagen, type VI, alpha 1	11.0	Disorders
24	ZMYM2	zinc finger, MYM-type 2	11.0
25	DCLK2	doublecortin-like kinase 2	11.0
26	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	11.0	Disorders
27	TBCC	tubulin folding cofactor C	10.1	Publications
28	TIAM1	T-cell lymphoma invasion and metastasis 1	-10.0	Publications

Pathways related to quadriplegia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Other glycan degradation20	9.8	FUCA1, FUCA2

Compounds related to quadriplegia according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	l-fucose32 18	10.8	FUCA1, FUCA2

Biological processes related to quadriplegia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fucose metabolic process	GO:006004	9.8	FUCA1, FUCA2

Molecular functions related to quadriplegia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	spectrin binding	GO:030507	9.7	ANK3, SPTAN1
2	alpha-L-fucosidase activity	GO:004560	9.5	FUCA1, FUCA2