LYSSA
MCID: RBS001
MIFTS: 51

Rabies (LYSSA) malady

Infectious, Neuronal categories

Summaries for Rabies

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Rabies is a deadly animal disease caused by a virus. it can happen in wild animals, including raccoons, skunks, bats and foxes, or in dogs, cats or farm animals. people get it from the bite of an infected animal. in people, symptoms of rabies include fever, headache and fatigue, then confusion, hallucinations and paralysis. once the symptoms begin, the disease is usually fatal. a series of shots can prevent rabies in people exposed to the virus. you need to get them right away. if an animal bites you, wash the wound well; then get medical care. to help prevent rabies vaccinate your pet. rabies vaccines are available for dogs, cats and farm animals don't let pets roam don't approach stray animals. animals with rabies might be aggressive and vicious, or tired and weak centers for disease control and prevention

MalaCards: Rabies, also known as LYSSA, is related to western equine encephalitis and viral encephalitis, and has symptoms including pharyngitis, hypersialorrhea and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Rabies is IGHM (immunoglobulin heavy constant mu), and among its related pathways is Immune response IFN alpha/beta signaling pathway. The compounds sulfatide and biotin have been mentioned in the context of this disorder. Affiliated tissues include brain or, whole blood and lymph node.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. the infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.

CDC:3 Rabies is a preventable viral disease of mammals most often transmitted through the bite of a rabid animal. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like raccoons, skunks, bats, and foxes.

Wikipedia:64 Rabies (/ˈreɪbiːz/; from Latin: rabies, \"madness\") is a viral disease that causes acute... more...

Aliases & Classifications for Rabies

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
rabies:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

rabies 8 43 10 45 49 34 61
lyssa 8 43


External Ids:

Disease Ontology8 DOID:11260
ICD9CM27 071
NCIt40 C28182
MeSH35 D011818
MESH via Orphanet36 D011818
ICD10 via Orphanet26 A82
SNOMED-CT via Orphanet58 14168008
UMLS via Orphanet62 C0034494
ICD1025 A82, A82.9

Related Diseases for Rabies

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Rabies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1western equine encephalitis10.2
2viral encephalitis10.2
3tetanus10.2
4myelitis10.1
5erythema multiforme10.1
6rhinotracheitis10.1
7vaccinia10.1
8st. louis encephalitis10.1
9eastern equine encephalitis10.1
10stomatitis10.1
11transverse myelitis10.1
12guillain-barr� syndrome10.1
13hypersensitivity reaction type ii disease10.0HLA-G, IFN1@, ITIH4, RNPC3, MPZ, IGHM
14viral infectious disease10.0MPZ, IFN1@, MX1, RNPC3, HLA-G, ITIH4
15hepatitis b10.0IFN1@, MX1, ITIH4, RNPC3, IGHM
16hepatitis c10.0MX1, IGHM, IFN1@, RNPC3
17influenza10.0RNPC3, ITIH4, MX1
18ipex syndrome10.0IFN1@, ITIH4, HLA-G, IGHM, RNPC3
19burkitt's lymphoma10.0AIFM1, RNPC3, MX1, HLA-G, IGHM
20myositis10.0RNPC3, HLA-G
21measles10.0RNPC3, MX1
22multiple sclerosis10.0IFN1@, MX1, HLA-G, MPZ
23spinal muscular atrophy10.0RNPC3, MPZ
24rift valley fever10.0MX1
25hepatitis10.0MX1
26chronic lymphocytic leukemia10.0AIFM1, HLA-G, IGHM
27coronary artery disease,9.9
28newcastle disease9.9
29cowpox9.9
30melanomatosis9.9
31post-vaccinal encephalitis9.9
32borna disease9.9
33leptospirosis9.9
34neuronitis9.9
35lyme disease9.9
36reactive arthritis9.9
37sarcocystosis9.9
38kawasaki disease9.9
39n syndrome9.9
40arthritis9.9
41brain disease9.9
42toxoplasmosis9.9
43tularemia9.9
44vasculitis9.9
45tetrahydrobiopterin deficiency9.9
46neurologic diseases9.9
47herpes simplex encephalitis9.9
48mycobacterium chelonae9.9
49small fiber neuropathy9.9
50acute transverse myelitis9.9

Graphical network of the top 20 diseases related to Rabies:



Diseases related to rabies

Clinical Features for Rabies

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 29)
  • pharyngitis
  • hypersialorrhea
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • larynx/laryngeal palsy
  • facial pain/cephalalgia/migraine
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • insomnia
  • hyperactivity/attention deficit
  • psychic/behavioural troubles
  • delirium/hallucination
  • anorexia
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • fever/chilling
  • motor deficit/trouble
  • acute palsy
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • seizures/epilepsy/absences/spasms/status epilepticus
  • obnubilation/coma/lethargia/desorientation
  • fever
  • headache
  • prickling or itching sensation at the site of bite
  • anxiety
  • confusion
  • agitation
  • delirium
  • difficulty swallowing
  • hydrophobia
  • paralysis

Drugs & Therapeutics for Rabies

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rabies

Drug clinical trials:

Search ClinicalTrials for Rabies

Search NIH Clinical Center for Rabies

Search CenterWatch for Rabies

Genetic Tests for Rabies

Anatomical Context for Rabies

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Rabies:

33
Whole blood, Lymph node, Brain, Cortex, Spinal cord, Lung, Skin, Monocytes, T cells, B cells, Dorsal root ganglion

FMA organs/tissues related to Rabies:

14
Brain or

Animal Models for Rabies or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Rabies

Sources:
51PubMed
See all sources

Articles related to Rabies:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Rabies expert takes up post in the Caribbean. (24391174)
2014
2
Relationship between virus-neutralizing antibody levels and the number of rabies vaccinations: a prospective study of dogs in Japan. (23429079)
2013
3
Systems thinking needed for rabies control. (23332953)
2013
4
A multi-dose serological assay suitable to quantify the potency of inactivated rabies vaccines for veterinary use. (24144483)
2013
5
Rabies virus infection in Eptesicus fuscus bats born in captivity (naA^ve bats). (23741396)
2013
6
Cellular chaperonin CCTI^ contributes to rabies virus replication during infection. (23637400)
2013
7
Expression changes of cytoskeletal associated proteins in proteomic profiling of neuroblastoma cells infected with different strains of rabies virus. (23168799)
2013
8
Genetic diversity and molecular evolution of the rabies virus matrix protein gene in China. (23453987)
2013
9
Rabid fox bites and human rabies in a village community in southern India: epidemiological and laboratory investigations, management and follow-up. (23473223)
2013
10
Current and future approaches to the therapy of human rabies. (23369672)
2013
11
Infectivity of rabies virus-exposed macrophages. (23159243)
2013
12
Evaluation of an indirect rapid immunohistochemistry test for the differentiation of rabies virus variants. (23541783)
2013
13
Official batch control of rabies veterinary vaccines: current situation and perspectives in the European Union. (23614550)
2013
14
Raccoon rabies virus variant transmission through solid organ transplantation. (23917290)
2013
15
Emergence of rabies in the Gauteng Province, South Africa: 2010-2011. (23718320)
2013
16
Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. (24136727)
2013
17
Complete genome sequences of three rabies viruses isolated from rabid raccoon dogs and a cow in Korea. (23975690)
2013
18
Laboratory Diagnosis of Human Rabies: Recent Advances. (24348170)
2013
19
Erythema multiforme after rabies vaccination. (24283444)
2013
20
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. (24069466)
2013
21
Oral vaccination and protection of red foxes (Vulpes vulpes) against rabies using ONRAB(Ar), an adenovirus-rabies recombinant vaccine. (24374501)
2013
22
Prevention and Control of Rabies in an Age of Global Travel: A Review of Travel- and Trade-Associated Rabies Events - United States, 1986-2012. (23870674)
2013
23
Pre-exposure rabies immunisation. (24362807)
2013
24
Enzootic and epizootic rabies associated with vampire bats, peru. (23969087)
2013
25
Rabies in Asia: the classical zoonosis. (22678037)
2013
26
Bovine rabies in Turkey: patterns of infection and implications for costs and control. (24280252)
2013
27
Management of a wild animal bite in a rabies enzootic area. (22860504)
2012
28
Case report: Evidence of rise in rabies cases in southern Malawi--better preventative measures are urgently required. (23638276)
2012
29
Rabies after corneal transplantation: non-canine rabies and eye banking. (23278792)
2012
30
Resistance to rabies. (22855748)
2012
31
Immune response and protection in raccoons (Procyon lotor) following consumption of baits containing ONRABAr, a human adenovirus rabies glycoprotein recombinant vaccine. (23060502)
2012
32
Rabies after lung transplantation: Existed evidence. (22754679)
2012
33
Expression, purification and characterization of a human single-chain Fv antibody fragment fused with the Fc of an IgG1 targeting a rabies antigen in Pichia pastoris. (22982755)
2012
34
Isolation and identification of a novel rabies virus lineage in China with natural recombinant nucleoprotein gene. (23226506)
2012
35
Modeling seasonal rabies epidemics in China. (22383117)
2012
36
The raccoon (Procyon lotor) as potential rabies reservoir species in Germany: a risk assessment. (22712420)
2012
37
The blueprint for rabies prevention and control: a novel operational toolkit for rabies elimination. (22389727)
2012
38
A quantitative release assessment for the noncommercial movement of companion animals: risk of rabies reintroduction to the United kingdom. (22486335)
2012
39
Canine rabies vaccination and domestic dog population characteristics in the developing world: a systematic review. (22480924)
2012
40
Production and evaluation of a chromatographically purified Vero cell rabies vaccine (PVRV) in China using microcarrier technology. (22894963)
2012
41
Community survey after rabies outbreaks, Flagstaff, Arizona, USA. (22607999)
2012
42
Domestic dog demographic structure and dynamics relevant to rabies control planning in urban areas in Africa: the case of Iringa, Tanzania. (23217194)
2012
43
Molecular epidemiology of rabies in Ukraine. (22661376)
2012
44
Six fatal cases of classical rabies virus without biting incidents, Iran 1990-2010. (22554714)
2012
45
Evaluation of a monoclonal antibody-based rapid immunochromatographic test for direct detection of rabies virus in the brain of humans and animals. (22492163)
2012
46
Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. (21084487)
2011
47
Rabies viral encephalitis: clinical determinants in diagnosis with special reference to paralytic form. (19965838)
2010
48
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. (19247444)
2009
49
Comparison of the susceptibility of the red fox (Vulpes vulpes) to a vaccinia-rabies recombinant virus and to cowpox virus. (7625119)
1995
50
Factors inhibiting the interference of western equine encephalitis virus by rabies virus in chick embryo tissue cultures. (14022024)
1963

Genetic Variations for Rabies

Expression for genes affiliated with Rabies

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rabies

Search GEO for disease gene expression data for Rabies.

Pathways for genes affiliated with Rabies

Sources:
54Reactome, 12EMD Millipore
See all sources

Pathways related to Rabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
10.7MX1, HLA-G, IFNA4

Compounds for genes affiliated with Rabies

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Rabies according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulfatide4510.6MPZ, ITIH4
2biotin45 11 2412.4RNPC3, MPZ, ITIH4

GO Terms for genes affiliated with Rabies

Sources:
16Gene Ontology
See all sources

Biological processes related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160710.7MX1, DHX58, IFNA4
2type I interferon-mediated signaling pathwayGO:06033710.6MX1, HLA-G, IFNA4
3response to virusGO:00961510.4MX1, DHX58, IFNA4

Products for genes affiliated with Rabies

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rabies

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet