LYSSA
MCID: RBS001
MIFTS: 56

Rabies (LYSSA) malady

Infectious diseases, Neuronal diseases categories

Summaries for Rabies

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Rabies is a deadly animal disease caused by a virus. it can happen in wild animals, including raccoons, skunks, bats and foxes, or in dogs, cats or farm animals. people get it from the bite of an infected animal. in people, symptoms of rabies include fever, headache and fatigue, then confusion, hallucinations and paralysis. once the symptoms begin, the disease is usually fatal. a series of shots can prevent rabies in people exposed to the virus. you need to get them right away. if an animal bites you, wash the wound well; then get medical care. to help prevent rabies vaccinate your pet. rabies vaccines are available for dogs, cats and farm animals don't let pets roam don't approach stray animals. animals with rabies might be aggressive and vicious, or tired and weak centers for disease control and prevention

MalaCards: Rabies, also known as LYSSA, is related to encephalitis and neuronitis, and has symptoms including prickling or itching sensation at the site of bite, anxiety and agitation. An important gene associated with Rabies is IGHM (immunoglobulin heavy constant mu), and among its related pathways is Immune response IFN alpha/beta signaling pathway. The compounds sulfatide and biotin have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and spinal cord.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. the infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.

CDC:3 Rabies is a preventable viral disease of mammals most often transmitted through the bite of a rabid animal. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like raccoons, skunks, bats, and foxes.

Wikipedia:63 Rabies (/ˈreɪbiːz/; from Latin: rabies, \"madness\") is a viral disease that causes acute... more...

Aliases & Classifications for Rabies

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
rabies:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

rabies 8 42 10 44 48 33 60
lyssa 8 42


External Ids:

Disease Ontology8 DOID:11260
ICD9CM27 071
NCIt39 C28182
MeSH34 D011818
MESH via Orphanet35 D011818
SNOMED-CT via Orphanet57 14168008
ICD10 via Orphanet26 A82.0, A82.1, A82.9
UMLS via Orphanet61 C0034494
ICD1025 A82, A82.9

Related Diseases for Rabies

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Rabies:



Diseases related to rabies

Clinical Features for Rabies

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 29)
  • prickling or itching sensation at the site of bite
  • anxiety
  • agitation
  • delirium
  • difficulty swallowing
  • hydrophobia
  • psychic/behavioural troubles
  • confusion
  • paralysis
  • headache
  • hyperactivity/attention deficit
  • fever/chilling
  • obnubilation/coma/lethargia/desorientation
  • delirium/hallucination
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • seizures/epilepsy/absences/spasms/status epilepticus
  • motor deficit/trouble
  • facial pain/cephalalgia/migraine
  • anorexia
  • fever
  • larynx/laryngeal palsy
  • hypersialorrhea
  • acute diarrhea
  • acute palsy
  • insomnia
  • pharyngitis
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Rabies

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rabies

Drug clinical trials:

Search ClinicalTrials for Rabies

Search NIH Clinical Center for Rabies

Search CenterWatch for Rabies

Genetic Tests for Rabies

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Anatomical Context for Rabies

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Rabies:

32
Brain, Spinal cord, Testes, Cortex, B cells, Skin, Dorsal root ganglion, Lymph node, Eye, Lung, Monocytes, T cells

FMA organs/tissues related to Rabies:

14
Brain or

Animal Models for Rabies or affiliated genes

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Publications for Rabies

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Sources:
50PubMed
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Articles related to Rabies:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Prioritization of capacities for the elimination of dog-mediated human rabies in the Americas: building the framework. (24392676)
2013
2
Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman Moore strain) manufactured in India. (24030586)
2013
3
Prevalence of rabies in various species in yemen and risk factors contributing to the spread of the disease. (23984026)
2013
4
Rabies pre-exposure vaccination of children with purified chick embryo cell vaccine (PCECV). (23571224)
2013
5
Rabies, readiness, and role 1 medical care. (24083933)
2013
6
Review of human rabies prophylaxis and treatment. (23692940)
2013
7
Using serology to assist with complicated post-exposure prophylaxis for rabies and Australian bat lyssavirus. (23469301)
2013
8
Oral rabies vaccination in raccoons: comparison of ONRABAr and RABORAL V-RGAr vaccine-bait field performance in QuAcbec, Canada and Vermont, USA. (23307388)
2013
9
Taming the beast: rabies control in the cradle of mankind. (23733302)
2013
10
Surveillance guidelines for disease elimination: a case study of canine rabies. (23260376)
2013
11
Bat rabies, public health and European bat conservation. (22909028)
2013
12
Phylogeographic dispersion and diversification of rabies virus lineages associated with dogs and crab-eating foxes (Cerdocyon thous) in Brazil. (23749047)
2013
13
Determinants of delay in initiating post-exposure prophylaxis for rabies prevention among animal bite cases: Hospital based study. (24188758)
2013
14
Genetic diversity and geographic distribution of genetically distinct rabies viruses in the Philippines. (23593515)
2013
15
Rabies post-exposure prophylaxis. (24079054)
2013
16
Serological investigation of rabies virus neutralizing antibodies in bats captured in the eastern Brazilian Amazon. (24100701)
2013
17
Protection of Mice Against Lethal Rabies Virus Challenge Using Short Interfering RNAs (siRNAs) Delivered Through Lentiviral Vector. (23877894)
2013
18
Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta). (23852288)
2013
19
Geographical analysis of the distribution and spread of human rabies in china from 2005 to 2011. (23991098)
2013
20
Coronary artery dilatation and vasculitis in a case of rabies: similarity with Kawasaki disease? (23679164)
2013
21
A community-based participatory study investigating the epidemiology and effects of rabies to livestock owners in rural Ethiopia. (22884728)
2013
22
Rabies virus glycoprotein is an important determinant for the induction of innate immune responses and the pathogenic mechanisms. (23265241)
2013
23
A next-generation, serum-free, highly purified Vero cell rabies vaccine is safe and as immunogenic as the reference vaccine VerorabAr when administered according to a post-exposure regimen in healthy children and adults in China. (24148575)
2013
24
An assessment of ONRAB oral rabies vaccine persistence in free-ranging mammal populations in Ontario, Canada. (23499602)
2013
25
Rabies. (24049000)
2013
26
Reporting rabies risk. (24317617)
2013
27
Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level. (23410236)
2013
28
The present and future of rabies vaccine in animals. (23596586)
2013
29
Towards a science of rabies elimination. (24088333)
2013
30
Reporting rabies risk. (24337096)
2013
31
First human rabies case in French Guiana, 2008: epidemiological investigation and control. (22363830)
2012
32
Adaptation of a Chinese ferret badger strain of rabies virus to high-titered growth in BHK-21 cells for canine vaccine development. (22886183)
2012
33
Typing of the rabies virus in Chile, 2002-2008. (22458941)
2012
34
Lack of genetic structure and female-specific effect of dispersal barriers in a rabies vector, the striped skunk (Mephitis mephitis). (23166760)
2012
35
Molecular inferences suggest multiple host shifts of rabies viruses from bats to mesocarnivores in Arizona during 2001-2009. (22737076)
2012
36
Rabies prevention in people who travel overseas. (23272416)
2012
37
Role of nuclear factor-I_B in oxidative stress associated with rabies virus infection of adult rat dorsal root ganglion neurons. (22623795)
2012
38
Rabies viral encephalitis with proable 25 year incubation period! (22919200)
2012
39
Evaluation of a direct rapid immunohistochemical test (dRIT) for rapid diagnosis of rabies in animals and humans. (23055005)
2012
40
Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression. (23071441)
2012
41
U.S-acquired human rabies with symptom onset and diagnosis abroad, 2012. (23034584)
2012
42
Complete genome sequence of a street rabies virus isolated from a rabid dog in China. (22966185)
2012
43
Analysis on factors related to rabies epidemic in China from 2007-2011. (22492004)
2012
44
Diversity of currently circulating rabies virus strains in Croatia. (22712423)
2012
45
Role of apoptosis in rabies viral encephalitis: a comparative study in mice, canine, and human brain with a review of literature. (21876844)
2011
46
Small fiber neuropathy following vaccination for rabies, varicella or Lyme disease. (19808027)
2009
47
The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. (17287281)
2007
48
Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine. (9846820)
1998
49
Efficacy study of a new albumin-free human diploid cell rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai patients. (7483780)
1995
50
INFLUENCE OF ANESTHESIA ON EXPERIMENTAL NEUROTROPIC VIRUS INFECTIONS : II. IN VITRO STUDIES WITH THE VIRUSES OF WESTERN AND EASTERN EQUINE ENCEPHALOMYELITIS, ST. LOUIS ENCEPHALITIS, POLIOMYELITIS (LANSING), AND RABIES. (19871636)
1947

Genetic Variations for Rabies

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Expression for genes affiliated with Rabies

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rabies

Search GEO for disease gene expression data for Rabies.

Pathways for genes affiliated with Rabies

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53Reactome, 12EMD Millipore
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Pathways related to Rabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
10.7MX1, HLA-G, IFNA4

Compounds for genes affiliated with Rabies

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Sources:
44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Rabies according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulfatide4410.6MPZ, ITIH4
2biotin44 11 2412.4RNPC3, MPZ, ITIH4

GO Terms for genes affiliated with Rabies

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16Gene Ontology
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Biological processes related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160710.7MX1, DHX58, IFNA4
2type I interferon-mediated signaling pathwayGO:06033710.6MX1, HLA-G, IFNA4
3response to virusGO:00961510.4MX1, DHX58, IFNA4

Products for genes affiliated with Rabies

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rabies

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet