Rabies malady

MedlinePlus: Rabies is a deadly animal disease caused by a virus. it can happen in wild animals, including raccoons, skunks, bats and foxes, or in dogs, cats or farm animals. people get it from the bite of an infected animal. in people, symptoms of rabies include fever, headache and fatigue, then confusion, hallucinations and paralysis. once the symptoms begin, the disease is usually fatal. a series of shots can prevent rabies in people exposed to the virus. you need to get them right away. if an animal bites you, wash the wound well; then get medical care. to help prevent rabies vaccinate your pet. rabies vaccines are available for dogs, cats and farm animals don't let pets roam don't approach stray animals. animals with rabies might be aggressive and vicious, or tired and weak centers for disease control and prevention²³

MalaCards: Rabies, also known as lyssa, is related to immunodeficiency and neurologic diseases, and has symptoms including fever, headache and prickling or itching sensation at the site of bite. An important gene associated with Rabies is IGHM (immunoglobulin heavy constant mu), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Toll-Like Receptors Pathway. The compounds glucose and calcitriol have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and cortex, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. the infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.⁶

CDC: Rabies is a preventable viral disease of mammals most often transmitted through the bite of a rabid animal. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like raccoons, skunks, bats, and foxes.²

Wikipedia: Rabies (pronounced⁴⁴ more...

Aliases & Descriptions:

rabies 6 30 8 32 23 lyssa 6 30

rabies (disorder) 43

Diseases related to rabies by text searches and GeneDecks gene sharing:

(show top 50)    (show all 875)

id	Related Disease	Score	Top Affiliating Genes
1	immunodeficiency	29.4	RBP3, VIP, PARP1, MPZ, CD28, CD274
2	neurologic diseases	27.5	PARP1, CHI3L1, MPZ, ITIH4, GSTM1, GSTT1
3	encephalitis	26.1	VEGFA, BCL2, CHI3L1, MX1, CD274, ITIH4
4	encephalomyelitis	25.9	VIP, VEGFA, VEGFB, MPZ, CD86, ITGB3
5	herpes simplex	23.7	GC, VIM, VEGFA, VDR, RAB1A, RAB1B
6	neuronitis	15.5	NCAM1, REN, SERPINE2, SETD2, VIM, VIP
7	hand, foot and mouth disease	14.2	MX1, ITIH4, IRF3, IRF7, IFNA1, ERVW-1
8	lacrimal duct obstruction	14.0	SFTPB, MMP3, GSTP1, FGF1, CCL11, IGES
9	parainfluenza virus type 3	14.0	MX1, IFNA1, DDX58, RNPC3, STAT1
10	asthma	13.9	IL12B, IL13, CCL11, HLA-G
11	herpes gestationis	13.9	ITIH4, APP, MBP, ERVK-6, CYSLTR2, NRP1
12	xanthomatosis	13.9	LPA, MSR1, HMGCR, CYP27A1, CYP27B1
13	central pontine myelinolysis	13.9	MPZ, MMP12, APP, MBP, ERVW-1, CTLA4
14	chronic inflammatory demyelinating polyradiculoneuropathy	13.9	MPZ, MBP, IFNG, TBX21, STAT1
15	fetal parainfluenza virus type 3 syndrome	13.9	MX1, CCL5, IFNA1, STAT2, STAT1
16	neurilemmoma	13.9	VIM, BMP2, MPZ, FGF1, MBP, EZR
17	sycp3-related pregnancy loss, susceptibility to	13.8	CGA, GSTT1, F10, HLA-G, TPO
18	t-cell leukemia	13.8	BCL2, CD28, ITIH4, CASP8, CAV1, CASP9
19	placental abruption	13.8	HLA-G, CTLA4, NOS3, NOTCH1, AGT, EPHX1
20	pre-eclampsia	13.8	NOS3, EDN1, AGT, EPHX1
21	secondary syphilis	13.8	GC, VDR, BMP2, CD36, CYP27B1, LTA
22	rickets	13.8	GC, VDR, CD36, ALB, CYP24A1, CYP27A1
23	autoimmune hepatitis	13.8	FTCD, CD14, CD274, GSTT1, IFNA1, TPO
24	superficial basal cell carcinoma	13.8	BCL2, IFNA1, DLL1, NOTCH1
25	diffuse gastric cancer	13.8	CDH1, GSTM1, GSTP1, GSTT1, CTNNB1
26	newcastle disease	13.7	MX1, IRF3, IRF7, IFNA1, DDX58, OCA2
27	osteomalacia	13.7	GC, VDR, CD36, GSTM1, GSTP1, GSTT1
28	htlv-1 associated myelopathy/tropical spastic paraparesis	13.7	VDR, CD274, MBP, CX3CR1
29	eosinophilic gastroenteritis	13.7	CCL11, IGES, IGHE, ALB
30	eosinophilic pneumonia	13.7	IL13, CCL11, CCL5, IGHE
31	adult t-cell leukemia	13.7	NCAM1, BCL2, MX1, IL4R, CASP8, CASP9
32	polyradiculoneuropathy	13.7	MPZ, MBP, IFNG, ALB, TBX21, STAT1
33	cadasil	13.7	APP, MBP, DLL1, NRP1, NOTCH1
34	primary biliary cirrhosis	13.7	VDR, ALB, CTLA4, RNPC3, LTA, TLR3
35	bladder cancer susceptibility	13.7	NAT2, PARP1, GSTM1, GSTP1, GSTT1, CAV1
36	hodgkin's lymphoma	13.7	BSG, BCL2, CD28, IL13, MDM2, CCL11
37	cellulitis	13.7	SETD2, CD36, IGES, F10, HIF1A, PRNP
38	benign tumors	13.7	VIM, BSG, MMP14, FLT1, FLCN, FGF1
39	homocystinuria	13.7	CD36, ALB, TPO, NOTCH1, G6PD, AAVS1
40	aortic valve stenosis	13.7	BMP2, ELN, AGT, NPPA, NPPB
41	aortic coarctation	13.6	NOS3, EDN1, AGT, ADRB2
42	postural orthostatic tachycardia syndrome	13.6	REN, NOS1, NOS3, AGT, ADRB2
43	essential thrombocythemia	13.6	NCAM1, CD36, ITGB3, IFNA1, ERVK-6, TPO
44	oxyphilic adenoma	13.6	VIM, FLCN, FHIT, CAV1, DEFB1, NME1
45	htlv-1 associated myelopathy	13.6	VDR, CD274, MBP, IFNA1, CX3CR1
46	intrinsic asthma	13.6	IL4, CCL5, IGES, IGHE
47	chronic lymphocytic leukemia	13.6	BCL2, CD28, CD86, IL4, MDM2, IGHM
48	orofacial cleft	13.6	NAT2, CDH1, GSTM1, GSTP1, GSTT1, NOS3
49	intraocular melanoma	13.6	CDKN2A, MDM2, EZR, CASP9, NGFR, NME1
50	aggressive digital papillary adenocarcinoma	13.6	SETD2, VIM, BSG, CDH1, MMP14, HTR1A

Symptoms: fever, headache, prickling or itching sensation at the site of bite, anxiety, confusion, agitation, delirium, difficulty swallowing, hydrophobia, paralysis.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to rabies:

²²

FMA organs/tissues related to rabies:

¹¹

MGI Mouse Phenotypes related to rabies:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.6	BCL2, CD28, CD86, CD274, IRAK3, FLG
2	respiratory system phenotype	MP:0005388	10.5	CD14, ITGB3, IL12A, IL12B, CCL24, IGHM
3	craniofacial phenotype	MP:0005382	10.5	LAMP1, T, MNT, FLG, IL12B, CASP9
4	renal/urinary system phenotype	MP:0005367	10.1	REN, MYLK, BCL2, MMP14, FLCN, IGHM
5	embryogenesis phenotype	MP:0005380	10.0	SFRP2, SFRP5, SETD2, VIM, RAD51, PARP1
6	endocrine/exocrine gland phenotype	MP:0005379	10.0	SFRP2, SFRP5, SERPINE2, AVPR1B, MNT, IFNG
7	limbs/digits/tail phenotype	MP:0005371	9.3	SFRP2, SFRP5, VEGFA, VDR, BMP2, LEP
8	other phenotype	MP:0005395	9.1	KDR, MSR1, CDKN2A, ITGB3, MMP14, IL13
9	immune system phenotype	MP:0005387	9.0	REN, SERPINE2, VIM, BSG, VDR, MYLK
10	pigmentation phenotype	MP:0001186	9.0	BCL2, LEP, CDKN2A, MDM2, TP53, CTLA4
11	nervous system phenotype	MP:0003631	8.9	REN, SFRP2, SFRP5, RBP3, SERPINE2, VEGFB
12	no phenotypic analysis	MP:0003012	8.9	SFRP2, SERPINE2, VEGFA, PARP1, T, CD274
13	liver/biliary system phenotype	MP:0005370	8.7	VEGFA, CD36, ITIH4, INSIG2, GPR77, IFNG
14	growth/size phenotype	MP:0005378	8.4	REN, SFRP2, SFRP5, SETD2, BSG, VDR
15	skeleton phenotype	MP:0005390	8.4	GC, VEGFA, VDR, BMP2, KDR, LEP
16	hearing/vestibular/ear phenotype	MP:0005377	8.3	VDR, BMP2, PARP1, BCL2, FLG, IL13
17	adipose tissue phenotype	MP:0005375	8.1	BCL2, LEP, CD36, CD14, GPR77, CAV2
18	integument phenotype	MP:0010771	8.1	PARP1, BCL2, LAMP1, T, CD274, MNT
19	normal phenotype	MP:0002873	8.0	REN, SFRP2, SFRP5, VIP, NANOS1, VEGFA
20	digestive/alimentary phenotype	MP:0005381	7.1	VEGFA, VDR, MYLK, BMP2, BCL2, LEP
21	reproductive system phenotype	MP:0005389	7.1	REN, SFRP2, SFRP5, SERPINE2, VIP, VEGFA
22	behavior/neurological phenotype	MP:0005386	7.0	NCAM1, REN, SFTPB, SERPINE2, VIM, VIP
23	mortality/aging	MP:0010768	6.8	NCAM1, REN, SFRP2, SFRP5, SFTPB, SETD2
24	tumorigenesis	MP:0002006	6.6	BCL2, LEP, CDKN2A, CDH1, MNT, ITGB3
25	vision/eye phenotype	MP:0005391	5.4	NCAM1, RBP3, VIM, VEGFA, VEGFB, KDR
26	homeostasis/metabolism phenotype	MP:0005376	4.8	REN, SFRP2, SFTPB, GC, SERPINE2, SETD2
27	cardiovascular system phenotype	MP:0005385	4.4	REN, SFRP2, SETD2, VIM, VEGFA, VEGFB
28	cellular phenotype	MP:0005384	4.1	NCAM1, SFRP2, SERPINE2, VIM, VEGFA, VDR
29	muscle phenotype	MP:0005369	4.0	REN, SFRP2, VIM, VEGFA, MYLK, KDR

Articles related to rabies:

(show all 36)

id	Title	Authors	Year	Affiliating Genes
1	Genetic dissection of interferon-antagonistic functio ns of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. (21084487)	Rieder M.... Conzelmann K.K.	2011	IRF3, IRF7
2	Ambivalent role of the innate immune response in rabi es virus pathogenesis. (21525357)	Chopy D.... Lafon M.	2011	DHX58
3	Rabies virus nucleoprotein functions to evade activat ion of the RIG-I-mediated antiviral response. (20130065)	Masatani T.... Sugiyama M.	2010	IRF3, DDX58
4	Rabies DNA vaccine: no impact of MHC class I and class II targeting sequences on immune response and protection against lethal challenge. (19356616)	Kaur M.... Bhatnagar R.	2009	LAMP1
5	Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. (19247444)	MAcnager P.... Lafon M.	2009	TLR3
6	Generalised cranial artery spasm in human rabies. (18634498)	Willoughby R.E.... Rupprecht C.E.	2008	NOS1
7	Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. (18490751)	Lafon M.... Wiendl H.	2008	CD274
8	Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFkappaB signaling pathway. (18082293)	Li J.... Dietzschold B.	2008	NFKB1
9	Expression of human anti-rabies Scds-Fv fusion protein in E.coli (17488607)	Cai K.... Yin J.	2007	F10
10	The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. (17287281)	Vidy A.... Blondel D.	2007	STAT1
11	Role of GPI-anchored NCAM-120 in rabies virus infection. (17208489)	Hotta K.... Yamada A.	2007	NCAM1
12	Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections. (17400066)	Megret F.... Lafon M.	2007	HLA-G, HLA-E
13	Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus. (16202617)	Leroy M.... Desmecht D.	2006	MX1, IFN1@
14	Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. (16501077)	Brzozka K.... Conzelmann K.K.	2006	STAT1, STAT2
15	Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases. (16877304)	Jackson A.C.... Lafon M.	2006	TLR3
16	Rabies viral mechanisms to escape the IFN system: the viral protein P interferes with IRF-3, Stat1, and PML nuclear bodies. (16689655)	Chelbi-Alix M.K.... Blondel D.	2006	STAT1, IFNA1
17	Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3. (15919920)	Brzozka K.... Conzelmann K.K.	2005	IRF3
18	Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways. (16254375)	Vidy A.... Blondel D.	2005	STAT1
19	Stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75NTR receptor. (16099913)	Sissoeff L.... Tuffereau C.	2005	NGFR
20	Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a r hesus macaque. (15564456)	McKenna P.M.... Schnell M.J.	2004	ERVW-1
21	Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies. (12825170)	Prosniak M.... Dietzschold B.	2003	IGHV4-31
22	High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection. (14554083)	Thoulouze M.I.... Lafon M.	2003	BCL2, AIFM1
23	Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor. (12163480)	Langevin C.... Tuffereau C.	2002	NGFR
24	Mutations conferring resistance to neutralization by a soluble form of the neurotrophin receptor (p75NTR) map outside of the known antigenic sites of the rabies virus glycoprotein. (12368318)	Langevin C.... Tuffereau C.	2002	SRR
25	Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies. (12439746)	Blondel D.... Chelbi-Alix M.K.	2002	PML
26	B-cell responses to myelin basic protein and its epitopes in autoimmune encephalomyelitis induced by Semple rabies vaccine. (10430042)	Piyasirisilp S.... Griffin D.E.	1999	MBP, MPZ
27	Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis. (10319881)	Piyasirisilp S.... Griffin D.E.	1999	MBP
28	Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine. (9846820)	Laouini D.... Dellagi K.	1998	MPZ
29	Molecular mimicry between the rabies virus glycoprotein and human immunodeficiency virus-1 GP120: cross-reacting antibodies induced by rabies vaccination. (9345046)	Bracci L.... Neri P.	1997	ITIH4
30	Efficacy study of a new albumin-free human diploid ce ll rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai pat ients. (7483780)	Wilde H.... Sumboonanondha A.	1995	ALB
31	Rabies virus selectively alters 5-HT1 receptor subtypes in rat brain. (8491253)	Ceccaldi P.E.... Fillion G.	1993	HTR1A
32	Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation. (8432980)	Ikematsu H.... Casali P.	1993	IGHM, IGHJ1
33	The clinical picture of rabies in a child. (1751647)	LisiA8 M.... PoljakoviA8 Z.	1991	IFNA4
34	Immunization of monkeys with rabies ribonucleoprotein (RNP) confers protective immunity against rabies. (2058261)	Tollis M.... Koprowski H.	1991	RNPC3
35	Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus. (2153188)	Ueki Y.... Casali P.	1990	IGHM
36	Antibody to peptides of human myelin basic protein in post-rabies vaccine encephalomyelitis sera. (1688875)	Ubol S.... Griffin D.E.	1990	MBP

Genes related to rabies according to GeneCards:

(show top 50)    (show all 223)

id	Symbol	Description	Score	GeneCards Section Context
1	IGHM	immunoglobulin heavy constant mu	11.0	Publications
2	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
3	MPZ	myelin protein zero	11.0	Publications
4	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
5	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
6	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	11.0	Publications
7	ERVK-6	endogenous retrovirus group K, member 6	11.0
8	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
9	COPD5	Chronic obstructive pulmonary disease QTL 5	10.9	Publications
10	MIR449A	microRNA 449a	10.9	Publications
11	IGHV4-31	immunoglobulin heavy variable 4-31	10.9	Publications
12	CHCHD2P9	coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9	10.9	Publications
13	IGHJ1	immunoglobulin heavy joining 1	10.9	Publications
14	IGHV3-30	immunoglobulin heavy variable 3-30	10.9
15	AAVS1	adeno-associated virus integration site 1	10.9	Publications
16	NANOS1	nanos homolog 1 (Drosophila)	10.9	Publications
17	IGHV4-39	immunoglobulin heavy variable 4-39	10.9
18	IFNA4	interferon, alpha 4	10.9	Publications
19	HAPLN2	hyaluronan and proteoglycan link protein 2	10.9
20	HBZ	hemoglobin, zeta	10.9	Publications
21	ZPBP2	zona pellucida binding protein 2	10.9	Publications
22	CYP21A1P	cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene	10.9	Publications
23	CYP2R1	cytochrome P450, family 2, subfamily R, polypeptide 1	10.9	Publications
24	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	10.9	Publications
25	ADAM8	ADAM metallopeptidase domain 8	10.9	Publications
26	GP5	glycoprotein V (platelet)	10.9	Publications
27	GPR77	G protein-coupled receptor 77	10.9	Publications
28	SFRP5	secreted frizzled-related protein 5	10.9	Publications
29	RAB1B	RAB1B, member RAS oncogene family	10.9	Orthologs
30	IFN1@	interferon, type 1, cluster	10.9	Publications
31	GSDMB	gasdermin B	10.9	Publications
32	MNT	MAX binding protein	10.9
33	ORMDL3	ORM1-like 3 (S. cerevisiae)	10.9	Publications
34	IL17RB	interleukin 17 receptor B	10.9	Publications
35	IPO13	importin 13	10.9	Publications
36	AVPR1B	arginine vasopressin receptor 1B	10.9	Publications
37	C21orf91	chromosome 21 open reading frame 91	10.9
38	SRR	serine racemase	10.9	Publications
39	DLL1	delta-like 1 (Drosophila)	10.9	Publications
40	INSIG2	insulin induced gene 2	10.9	Publications
41	FLCN	folliculin	10.9	Publications
42	GPR123	G protein-coupled receptor 123	10.9	Publications
43	HLA-DMA	major histocompatibility complex, class II, DM alpha	10.9	Publications
44	FTCD	formiminotransferase cyclodeaminase	10.9	Publications
45	DIO2	deiodinase, iodothyronine, type II	10.9	Publications
46	EDA2R	ectodysplasin A2 receptor	10.9	Publications
47	IGES	immunoglobulin E concentration, serum	10.9	Publications
48	LTBP4	latent transforming growth factor beta binding protein 4	10.9	Publications
49	PHF11	PHD finger protein 11	10.9	Publications
50	TLR10	toll-like receptor 10	10.9	Publications

Pathways related to rabies according to GeneDecks:

(show top 50)    (show all 142)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.8	IRAK1, TLR6, CCL11, CD14, IRAK3
2	Toll-Like Receptors Pathway36	10.7	TLR9, NFKB1, TLR2, TLR4, TLR6, TLR10
3	Toll-Like Receptor Signaling Pathways37	10.3	CD36, IRF7, IL1B, TLR9, TLR6, TLR4
4	TRAF Pathway36	10.3	IRAK1, TLR3, TLR2, TLR10, LTA, NFKB1
5	Akt Signaling36	10.2	BMP2, FGF1, CD28, VEGFB, CX3CR1, IL10
6	Immune response_TLR signaling pathways41	9.9	CD14, IRAK1, IRAK3, IL4, IL8, NFKB1
7	Th1 Differentiation37	9.9	IL12B, IFNG, TBX21, LTA, TLR10, TLR2
8	Autoimmune thyroid disease20	9.8	IL4, HLA-G, CTLA4, TPO, HLA-E, HLA-DMA
9	Type I diabetes mellitus20	9.7	IL12A, CD28, LTA, HLA-G, HLA-E, CD86
10	Allograft rejection20	9.6	CD28, CD86, IL10, IL12A, HLA-G, HLA-E
11	Th17 Differentiation37	9.6	CD86, IL12B, IL1B, TLR10, TLR2, TLR3
12	Toll-like receptor signaling pathway20	9.6	IFNA4, CASP8, NFKB1, TLR2, TLR3, TLR4
13	Endothelin-1 Signaling Pathway36	9.6	FLT1, IL12A, IL13, IL12B, IL1B, IL4
14	NF-KappaB (p50-p65) Pathway36	9.4	KDR, BMP2, VEGFB, FLT1, IRAK1, IRAK3
15	NF-KappaB Family Pathway36	9.3	TGFB1, THPO, TLR9, TLR6, TLR4, TLR3
16	MIF Regulation of Innate Immune Cells36	9.3	IL12A, TLR4, IL13, BCL2, CCL11, IL8
17	PGC1Alpha Pathway36	9.3	IL12A, IL12B, IL13, BMP2, IL1B, IL4
18	MIF Mediated Glucocorticoid Regulation36	9.2	BMP2, CD14, IL10, IL12B, IL13, IL1B
19	SOCS Pathway36	9.2	CCL24, IL4, IL1B, CCL11, VEGFB, BMP2
20	Influenza A20	9.2	PML, STAT1, STAT2, TLR4, TLR3, NFKB1
21	STAT3 Pathway36	9.2	CCL11, IL4R, IL4, IL1B, IL13, BCL2
22	Measles20	9.0	NFKB1, DDX58, TP53, IFNG, IFNA4, IFNA1
23	Apoptotic Pathways in Synovial Fibroblasts36	8.9	VEGFB, LTBP4, LTA, THPO, TGFB1, TGFBR1
24	PEDF Induced Signaling36	8.9	LTA, CASP8, IL1B, CCL5, CCL24, CCL11
25	p53 Mediated Apoptosis36	8.9	VEGFB, BCL2, FLT1, FGF1, MDM2, CASP8
26	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	TLR3, TLR2, IL12B, IL1B, IL4, IL4R
27	ERK Signaling36	8.7	LTBP4, IL13, THPO, IL12A, IL10, IL12B
28	Colorectal Cancer Metastasis36	8.6	TLR6, TLR9, TGFB1, TGFBR1, STAT1, CASP9
29	Tec Kinases Signaling36	8.6	NGFR, IRAK1, ITGB3, CD28, FGF1, IL10
30	Pancreatic Adenocarcinoma36	8.6	MMP12, LTBP4, TGFBR1, NFKB1, TP53, THPO
31	Cytokine Network36	8.6	IFNA1, IL10, IL12A, IL12B, IL13, IL1B
32	Pathways in cancer20	8.6	CASP9, CYCS, CTNNB1, TGFB1, BMP2, VEGFB
33	Mitochondrial Apoptosis36	8.6	FGF1, FLT1, CDKN2A, BCL2, MDM2, CASP8
34	DHA Signaling36	8.5	BMP2, TGFB1, LTBP4, VEGFB, NGFR, NRP1
35	Molecular Mechanisms of Cancer36	8.5	BMP2, KDR, BCL2, CDKN2A, CDH1, IL12B
36	TGF-Beta Pathway36	8.5	CDH1, BCL2, IL4, CCL11, IL8, IL4R
37	Cellular Apoptosis Pathway36	8.5	FLT1, CASP9, BCL2, CDKN2A, TGFB1, CASP8
38	Antioxidant Action of Vitamin-C36	8.4	IL12A, IL12B, IL13, IL1B, IL4R, IL4
39	Glucocorticoid Receptor Signaling36	8.4	CCL11, NFKB1, BMP2, BCL2, IL10, IL12A
40	MAPK Family Pathway36	8.4	NFKB1, NGFR, CCL5, LTA, LTBP4, THPO
41	Rheumatoid arthritis20	8.3	IL8, IL1B, VEGFA, CD28, CD86, MMP3
42	PAK Pathway36	8.3	IL13, IL1B, IL4, IL8, CCL11, CCL24
43	p38 Signaling36	8.2	CD28, CCL11, CCL24, CCL5, TP53, NGFR
44	Leishmaniasis20	8.2	STAT1, TGFB1, TLR4, TLR2, NFKB1, HLA-DMA
45	Toxoplasmosis20	8.2	CASP9, TLR4, NFKB1, CYCS, TGFB1, IRAK1
46	Chagas disease (American trypanosomiasis)20	8.0	TLR6, IFNG, CASP8, NFKB1, TGFBR1, TLR2
47	Rho Family GTPases36	8.0	HAPLN2, VIM, LTBP4, IL1B, IL4, NFKB1
48	Tuberculosis20	7.7	TLR2, NFKB1, CYP27B1, CYCS, HLA-DMA, CASP9
49	JAK-STAT Pathway36	7.4	VEGFB, BMP2, KDR, BCL2, FLT1, FGF1
50	Cytokine-cytokine receptor interaction20	7.2	IFNA4, IL10, FLT1, LEP, KDR, IL12A

Compounds related to rabies according to GeneDecks:

(show top 50)    (show all 462)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	SETD2, MYLK, AIFM1, TJP1, DIO2, THPO
2	calcitriol32 42 9 18 9	14.0	REN, GC, VDR, BMP2, CD36, CD14
3	hyaluronic acid32 18	10.9	VIM, CHI3L1, CD36, CDH1, MMP3, FGF1
4	egcg32	9.7	ITIH4, APP, CCL5, CASP9, ERVK-6, CYCS
5	atp32	9.6	NCAM1, SFTPB, SETD2, MYLK, RAD51, PARP1
6	calcium32 9 18 9	12.4	REN, SFTPB, SERPINE2, VIP, LPA, MYLK
7	forskolin32 42 9 9	12.4	REN, VIM, VIP, MYLK, BMP2, CGA
8	steroid32	9.3	REN, GC, BMP2, LEP, CGA, MPZ
9	mg 13232 42	10.2	VDR, PARP1, KDR, CDKN2A, CDH1, IL1B
10	glutamate32	9.2	NCAM1, GC, VIM, VIP, BSG, VDR
11	matrigel32	9.2	NCAM1, VIM, BSG, VEGFA, BMP2, KDR
12	heparin32 9 18 9	12.1	NCAM1, SERPINE2, VIM, BSG, VEGFB, LPA
13	tgf beta132	9.1	SETD2, KDR, CD36, CDH1, MMP14, MMP3
14	n acetylcysteine32	9.0	SETD2, KDR, MSR1, CDKN2A, CDH1, MMP12
15	oxygen32 18	9.9	SFTPB, SETD2, VEGFB, MYLK, BMP2, PARP1
16	wortmannin32 42	9.9	SETD2, VIM, MYLK, BMP2, RAD51, KDR
17	methacholine32 9 9	10.8	REN, VIP, CD14, IL13, IL4, IL8
18	histamine32 18	9.8	NCAM1, VIM, VIP, CGA, CD86, CD14
19	acetylcholine32 9 18 9	11.7	NCAM1, SERPINE2, VIM, VIP, LEP, CGA
20	poly(i-c)32	8.6	MX1, IRF3, IRF7, IL12B, IL1B, IL4
21	alanine32	8.6	NCAM1, VIP, VDR, MYLK, BMP2, RAD51
22	doxorubicin32 34 9 9	11.5	NCAM1, SETD2, VIM, PARP1, KDR, CGA
23	aspirin32 34 18	10.5	LPA, VDR, CGA, CDH1, ITGB3, GSTP1
24	cholesterol32 9 18 9	11.4	REN, SFTPB, GC, BSG, NAT2, LPA
25	rantes32	8.4	VIP, MX1, CD14, ITIH4, MMP3, IRAK1
26	estrogen32	8.3	GC, SETD2, VIP, BSG, NAT2, LPA
27	resveratrol32 9 18 9	11.3	BSG, VEGFA, VDR, BMP2, PARP1, BCL2
28	arginine32	8.3	REN, SFTPB, VIP, LPA, VDR, BMP2
29	s-nitroso-n-acetylpenicillamine32	7.8	PARP1, IL1B, IL8, IFNG, CASP9, CYCS
30	hydrocortisone32 9 9	9.8	REN, VIM, KDR, CD36, CD14, FLT1
31	prostacyclin32	7.7	REN, VIP, VEGFA, KDR, LEP, CGA
32	lipid32	7.7	NCAM1, SFTPB, GC, SERPINE2, SETD2, VIM
33	nitric oxide32 9 18 9	10.7	NCAM1, REN, SFTPB, RBP3, NANOS1, NAT2
34	thyroxine32 18	8.6	REN, GC, VIP, LPA, VDR, LEP
35	sb 20358032 42	8.5	SETD2, VIM, BSG, VEGFA, VDR, BMP2
36	curcumin32	7.4	VEGFA, PARP1, BCL2, MPZ, CDH1, MMP14
37	il 1032	7.1	VDR, IL10, IL12B, IL13, IL1B, IL4
38	lactate32	7.1	NCAM1, SETD2, VIM, VIP, BSG, BMP2
39	methotrexate32 34 42 9 9	10.9	VIM, NAT2, LEP, CGA, CDKN2A, CDH1
40	paraffin32	6.8	NCAM1, SFTPB, VIM, VEGFA, KDR, BCL2
41	genistein32 9 18 9	9.7	SETD2, VIM, VEGFA, VDR, BMP2, PARP1
42	butyrate32	6.7	RBP3, SETD2, VIM, VDR, BCL2, LEP
43	retinoic acid32 42 18	8.7	NCAM1, SFTPB, GC, RBP3, SETD2, VDR
44	paclitaxel32 34 9 9	9.6	SETD2, VIM, VEGFA, RAD51, PARP1, KDR
45	cisplatin32 34 9 9	9.6	SETD2, VEGFA, RAD51, PARP1, KDR, BCL2
46	cyclosporin a32 42	7.4	VIP, BSG, VDR, BMP2, LEP, CGA
47	tacrolimus32 34 9 9	9.2	REN, VDR, BMP2, MSR1, CD28, CD36
48	indomethacin32 9 9	8.0	REN, VIM, VIP, BMP2, KDR, LEP
49	actinomycin d32	4.8	SFTPB, SERPINE2, SETD2, VIM, VEGFA, LPA
50	dexamethasone32 42 34 9 9	7.6	NCAM1, REN, SFTPB, VIM, VIP, NAT2

Cellular components related to rabies according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	apical part of cell	GO:045177	10.2	EDA, NOS3, CTNNB1, SRR, TJP1, EZR
2	membrane raft	GO:045121	10.0	ADAM17, PRNP, TLR4, CAV1, CASP8, CAV2
3	integral to plasma membrane	GO:005887	9.7	EDA2R, EDA, NGFR, CTLA4, DLL1, TBXA2R
4	perinuclear region of cytoplasm	GO:048471	9.6	CTNNB1, NOS1, TLR4, CX3CR1, NPPA, NPPB
5	membrane	GO:016020	9.4	DOCK1, DIO2, CTNNB1, PDE4D, LTA, EDA
6	external side of plasma membrane	GO:009897	9.2	IL1RL1, IL4, ENPEP, IFNG, CTLA4, TLR2
7	plasma membrane	GO:005886	8.7	SRR, CTLA4, CTNNB1, CTNND1, NRP1, NOS3
8	cell surface	GO:009986	8.5	TPO, NGFR, TLR2, TLR3, TGFB1, ROBO1
9	cytosol	GO:005829	6.8	CYCS, CUL5, CTNNB1, CTNND1, PPARG, DDX58
10	extracellular space	GO:005615	6.5	WISP1, IL8, CCL11, CCL24, CCL5, IFNA4
11	cytoplasm	GO:005737	6.5	SRR, CTNNB1, CTNND1, NOD1, NOS1, NOS3
12	extracellular region	GO:005576	6.3	NGFR, NOTCH1, NRP1, DLL1, F10, ALB

Biological processes related to rabies according to GeneDecks:

(show top 50)    (show all 97)

id	Name	GO ID	Score	Top Affiliating Genes
1	type I interferon-mediated signaling pathway	GO:060337	10.8	MX1, IRF3, HLA-G, IRF7, IFNA4, HLA-E
2	positive regulation of interferon-beta production	GO:032728	10.8	TLR3, TLR9, DDX58, IRF7, IRF3, TLR4
3	positive regulation of inflammatory response	GO:050729	10.7	IL1RL1, IL12B, TLR9, TLR4, CCL24, TLR3
4	response to lipopolysaccharide	GO:032496	10.7	EDN1, SFTPB, IRAK1, NOTCH1, LTA, CYP27B1
5	Toll signaling pathway	GO:008063	10.6	NOD1, NFKB1, TLR2, TLR3, TLR4, TLR6
6	toll-like receptor 4 signaling pathway	GO:034142	10.6	NOD1, NFKB1, TLR2, IRAK1, TLR3, TLR4
7	response to virus	GO:009615	10.6	IL12A, CCL11, STAT1, STAT2, MX1, DDX58
8	positive regulation of chemokine production	GO:032722	10.5	HIF1A, TLR2, TLR3, TLR9, ADAM17, TLR4
9	positive regulation of NF-kappaB import into nucleus	GO:042346	10.5	TLR4, TLR3, TLR2, EDA, IL1B, IL12B
10	positive regulation of endothelial cell proliferation	GO:001938	10.4	HIF1A, VEGFA, KDR, BMP2, ITGB3, CCL11
11	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.3	TLR4, TLR3, NOD1, IRF7, IRF3, IRAK1
12	cytokine-mediated signaling pathway	GO:019221	10.3	MX1, IRF7, IRAK3, IL17RB, IL1B, IRF3
13	positive regulation of interleukin-6 production	GO:032755	10.3	TLR9, TLR3, CD36, IL1B, NOD1, TLR4
14	immune response	GO:006955	10.3	IL8, MBP, CCL11, IGHM, IGHE, HLA-DMA
15	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.2	IRF3, TLR6, TLR4, TLR9, CD36, IRAK1
16	positive regulation of angiogenesis	GO:045766	10.1	CCL11, CCL24, CCL5, TBXA2R, IL1B, NOS3
17	positive regulation of interleukin-12 production	GO:032735	10.1	TLR4, HLA-G, IFNG, CD36, IL12B, TLR3
18	cell-cell signaling	GO:007267	10.1	LTA, ADRA1B, WISP1, SFRP2, NRP1, BMP2
19	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.1	VEGFB, ITGB3, FLT1, IL1B, HIF1A, VEGFA
20	negative regulation of interleukin-17 production	GO:032700	10.1	IL12B, IFNG, TLR2, TLR4, PRNP, IL12A
21	innate immune response	GO:045087	10.0	APP, IFNA4, PPARG, TLR2, TLR10, DDX58
22	cellular response to mechanical stimulus	GO:071260	10.0	IL13, TLR3, AGT, NFKB1, CASP8, TLR4
23	positive regulation of tumor necrosis factor production	GO:032760	10.0	IL12B, IFNG, CD14, TLR2, CD36, TLR3
24	positive regulation of cell adhesion	GO:045785	10.0	CCL5, IFNG, VEGFA, FGF1, IL12A, IL12B
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	TLR4, VEGFA, VEGFB, CD36, ITGB3, TP53
26	interferon-gamma-mediated signaling pathway	GO:060333	10.0	PML, STAT1, HLA-G, IFNG, IRF7, IRF3
27	signal transduction	GO:007165	9.7	IL8, IL4R, IL1RL1, CCL11, CCL24, GPR123
28	positive regulation of smooth muscle cell apoptotic process	GO:034393	9.7	IFNG, IL12B, IL12A, CDKN2A
29	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.6	EDA, TLR4, EDA2R, AGT, ADAM8, NFKB1
30	positive regulation of endothelial cell migration	GO:010595	9.6	VEGFA, KDR, ITGB3, NRP1, AGT, EDN1
31	negative regulation of growth of symbiont in host	GO:044130	9.6	CD36, IL10, IL12B, IFNG, LTA, TLR2
32	positive regulation of T cell proliferation	GO:042102	9.6	CD28, CCL5, IL12A, IFNG, IL12B, IL1B
33	lipopolysaccharide-mediated signaling pathway	GO:031663	9.5	STAT1, TGFB1, TLR4, TLR2, CCL5, IL1B
34	negative regulation of smooth muscle cell proliferation	GO:048662	9.5	NPPB, PPARG, IFNG, IL12B, IL12A, NOS3
35	virus-host interaction	GO:019048	9.4	CAV1, CD86, DYNLL1, CASP8, VIM, KDR
36	cellular response to lipopolysaccharide	GO:071222	9.3	CD14, IFNG, IL8, IL12B, IL10, GSTP1
37	positive regulation of cell migration	GO:030335	9.3	CCL5, FLT1, VEGFA, TGFB1, EDN1, NOTCH1
38	positive regulation of apoptotic process	GO:043065	9.2	SFRP2, CTLA4, ADRB2, SOD1, TLR4, IL1B
39	inflammatory response	GO:006954	9.0	TLR10, TBXA2R, NOD1, NFKB1, TLR2, TLR3
40	aging	GO:007568	8.9	NOS3, VDR, SRR, AGT, IL1B, CCL5
41	positive regulation of cell proliferation	GO:008284	8.9	T, FLT1, FGF1, MDM2, CGA, LEP
42	negative regulation of cell growth	GO:030308	8.8	NPPA, TGFB1, AGT, PPARG, PML, CDKN2A
43	negative regulation of cell proliferation	GO:008285	8.7	SFRP5, CUL5, CTNNB1, NOS3, AGT, TGFB1
44	cell cycle arrest	GO:007050	8.4	CDKN2A, TP53, CUL5, TGFB1, TGFBR1, PRNP
45	response to hypoxia	GO:001666	8.4	BMP2, TGFB1, HIF1A, EDN1, LTA, NOS3
46	blood coagulation	GO:007596	8.2	NOS1, VEGFB, NOS3, THPO, SOD1, TGFB1
47	negative regulation of transcription from RNA polymerase II promoter	GO:000122	7.9	CAV1, NOTCH1, PPARG, TP53, VDR, NFKB1
48	positive regulation of transcription, DNA-dependent	GO:045893	7.7	TP53, CD86, BMP2, CDKN2A, CDH1, HIF1A
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	CTNNB1, BMP2, CGA, CDKN2A, IRF7, FGF1
50	response to drug	GO:042493	7.1	PPARG, NOS3, LTA, EDN1, TGFB1, SOD1

Molecular functions related to rabies according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:020037	10.4	HBZ, NOS3, NOS1, CYP2R1, CYP27B1, CYP27A1
2	iron ion binding	GO:005506	10.3	NOS3, NOS1, CYP2R1, CYP27B1, CYP27A1, CYP21A2
3	receptor activity	GO:004872	10.3	TLR6, TLR4, TLR3, TLR2, EDA2R, NGFR
4	ubiquitin protein ligase binding	GO:031625	9.7	PML, HIF1A, PDE4D, NGFR, SNX9, CUL5
5	hormone activity	GO:005179	9.7	NPPB, NPPA, THPO, AGT, EDN1, CGA
6	protein heterodimerization activity	GO:046982	9.2	HIF1A, TLR2, TLR6, TGFB1, PML, ADRA1B
7	protein homodimerization activity	GO:042803	9.0	PTPRE, SRR, SNX9, NOD1, NFKB1, G6PD
8	identical protein binding	GO:042802	9.0	ALAD, CASP8, TP53, DDX58, NOD1, PRNP
9	cytokine activity	GO:005125	8.9	IFNA4, IFNG, LTA, EDN1, TSLP, THPO
10	growth factor activity	GO:008083	8.5	IL1B, IL4, AGT, THPO, TGFB1, DKK1
11	protein binding	GO:005515	4.8	CAV1, CTLA4, CTNNB1, CTNND1, PPARG, SNX9