LYSSA
MCID: RBS001
MIFTS: 57

Rabies (LYSSA) malady

Rare diseases, Infectious diseases, Neuronal diseases categories

Summaries for Rabies

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Rabies is a deadly animal disease caused by a virus. it can happen in wild animals, including raccoons, skunks, bats and foxes, or in dogs, cats or farm animals. people get it from the bite of an infected animal. in people, symptoms of rabies include fever, headache and fatigue, then confusion, hallucinations and paralysis. once the symptoms begin, the disease is usually fatal. a series of shots can prevent rabies in people exposed to the virus. you need to get them right away. if an animal bites you, wash the wound well; then get medical care. to help prevent rabies vaccinate your pet. rabies vaccines are available for dogs, cats and farm animals don't let pets roam don't approach stray animals. animals with rabies might be aggressive and vicious, or tired and weak centers for disease control and prevention

MalaCards: Rabies, also known as LYSSA, is related to encephalitis and tetanus, and has symptoms including confusion, agitation and delirium. An important gene associated with Rabies is IGHM (immunoglobulin heavy constant mu), and among its related pathways are Cell adhesion molecules (CAMs) and Immune response IFN alpha beta signaling pathway. The compounds sulfatide and glycolipid have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and spinal cord, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology:9 A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. the infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.

CDC:4 Rabies is a preventable viral disease of mammals most often transmitted through the bite of a rabid animal. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like raccoons, skunks, bats, and foxes.

Wikipedia:66 Rabies (/?re?bi?z/; from Latin: rabies, \"madness\") is a viral disease that causes acute inflammation... more...

Aliases & Classifications for Rabies

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
rabies:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

rabies 9 44 11 46 50 35 63
lyssa 9 44


External Ids:

Disease Ontology9 DOID:11260
ICD9CM28 071
MeSH36 D011818
NCIt41 C28182
MESH via Orphanet37 D011818
SNOMED-CT via Orphanet60 14168008
ICD10 via Orphanet27 A82.0, A82.1, A82.9
UMLS via Orphanet64 C0034494
ICD1026 A82, A82.9

Related Diseases for Rabies

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Rabies:



Diseases related to rabies

Symptoms for Rabies

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Sources:
9Disease Ontology
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Symptoms:

9 (show all 29)
  • confusion
  • agitation
  • delirium
  • difficulty swallowing
  • hydrophobia
  • paralysis
  • facial pain/cephalalgia/migraine
  • anxiety
  • prickling or itching sensation at the site of bite
  • headache
  • psychic/behavioural troubles
  • hyperactivity/attention deficit
  • insomnia
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • larynx/laryngeal palsy
  • acute diarrhea
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hypersialorrhea
  • delirium/hallucination
  • anorexia
  • fever
  • obnubilation/coma/lethargia/desorientation
  • seizures/epilepsy/absences/spasms/status epilepticus
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • acute palsy
  • motor deficit/trouble
  • fever/chilling
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • pharyngitis

Drugs & Therapeutics for Rabies

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Rabies

Drug clinical trials:

Search ClinicalTrials for Rabies

Search NIH Clinical Center for Rabies

Search CenterWatch for Rabies

Genetic Tests for Rabies

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Anatomical Context for Rabies

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Rabies:

34
Brain, Spinal cord, Testes, B cells, Skin, Cortex, Eye, Dorsal root ganglion, Lung, Lymph node, Monocytes, T cells

FMA organs/tissues related to Rabies:

15
Brain or

Animal Models for Rabies or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Rabies:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0IGHM, HLA-G, MPZ, SRR, AIFM1
2MP:00053847.9ITIH4, SRR, MPZ, IGHM, AIFM1

Publications for Rabies

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53PubMed
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Articles related to Rabies:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Strategic model of national rabies control in Korea. (24427765)
2014
2
Rabies: Underused vaccines, unnecessary deaths. (24434045)
2014
3
A novel site-II directed glycoprotein estimation ELISA to aid rabies vaccine manufacture for veterinary and human use. (24262315)
2014
4
Development of a reverse genetics system for the aG strain of rabies virus in China. (24272786)
2013
5
Prioritization of capacities for the elimination of dog-mediated human rabies in the Americas: building the framework. (24392676)
2013
6
Rabies virus nucleoprotein expressed in silkworm pupae at high-levels and evaluation of immune responses in mice. (23178898)
2013
7
Characterization of street rabies virus variants with an additional N-glycan at position 247 in the glycoprotein. (23921623)
2013
8
Epidemiology of urban dog-related injuries requiring rabies post-exposure prophylaxis in Marseille, France. (23116608)
2013
9
Evaluation of an ELISA to detect rabies antibodies in orally vaccinated foxes and raccoon dogs sampled in the field. (23201293)
2013
10
Pre-exposure vaccination against rabies: are we being left in the lurch? (24123447)
2013
11
Making rabies prophylaxis more economical: Immunogenicity and safety results from a preliminary study using a 2-1 intramuscular regimen in healthy volunteers. (24008819)
2013
12
MRI in rabies encephalitis. (24172782)
2013
13
Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman Moore strain) manufactured in India. (24030586)
2013
14
Costs of rabies control: an economic calculation method applied to flores island. (24386244)
2013
15
Spatial epidemiology of bat-borne rabies in Colombia. (24096979)
2013
16
Gains and future road map for the elimination of dog-transmitted rabies in the americas. (24306030)
2013
17
The introduction of fox rabies into Italy (2008-2011) was due to two viral genetic groups with distinct phylogeographic patterns. (23603764)
2013
18
Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice. (23718883)
2013
19
Relationship between virus-neutralizing antibody levels and the number of rabies vaccinations: a prospective study of dogs in Japan. (23429079)
2013
20
WSAVA and OIE call for action on rabies. (24243670)
2013
21
Prevalence of rabies in various species in yemen and risk factors contributing to the spread of the disease. (23984026)
2013
22
Dog bite histories and response to incidents in canine rabies-enzootic KwaZulu-Natal, South Africa. (23593511)
2013
23
Recent emergence and spread of an Arctic-related phylogenetic lineage of rabies virus in Nepal. (24278494)
2013
24
Characterization of a wild rabies virus isolate of porcine origin in China. (23567821)
2013
25
Evidence-based control of canine rabies: a critical review of population density reduction. (23004351)
2013
26
Humoral immune response to oral rabies vaccination in raccoon kits: problems and implications. (23602534)
2013
27
Economic Evaluation of Vampire Bat (Desmodus rotundus) Rabies Prevention in Mexico. (22984914)
2012
28
Netherlands rabies case highlights importance of following pet travel rules. (22467819)
2012
29
Management of a wild animal bite in a rabies enzootic area. (22860504)
2012
30
Case report: Evidence of rise in rabies cases in southern Malawi--better preventative measures are urgently required. (23638276)
2012
31
Molecular characterization of the complete genome of a street rabies virus WH11 isolated from donkey in China. (22836559)
2012
32
Ecological and anthropogenic drivers of rabies exposure in vampire bats: implications for transmission and control. (22696521)
2012
33
Rabies after corneal transplantation: non-canine rabies and eye banking. (23278792)
2012
34
First human rabies case in French Guiana, 2008: epidemiological investigation and control. (22363830)
2012
35
Susceptibility and lack of evidence for a viremic state of rabies in the night owl monkey, Aotus nancymaae. (22612895)
2012
36
History of Rabies in Traditional Medicine's Resources and Iranian Research Studies: On the CccasiOn of the World Rabies Day (September 28, 2012). (23024845)
2012
37
Small interfering RNAs targeting the rabies virus nucleoprotein gene. (22884777)
2012
38
Request for pictures of rabies vaccine bait. (22435125)
2012
39
Post-exposure prophylaxis against rabies at two newly designated intradermal rabies vaccination clinics in Kerala, India. (23448625)
2012
40
Resistance to rabies. (22855748)
2012
41
Passive immunity in the prevention of rabies. (22541629)
2012
42
Moving from rabies research to rabies control: lessons from India. (22880139)
2012
43
Generation of a live rabies vaccine strain attenuated by multiple mutations and evaluation of its safety and efficacy. (22464967)
2012
44
Epidemiological and clinical features of human rabies cases in Bali 2008-2010. (22471410)
2012
45
Ambivalent role of the innate immune response in rabies virus pathogenesis. (21525357)
2011
46
Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. (21632762)
2011
47
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. (19247444)
2009
48
The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. (17287281)
2007
49
Role of GPI-anchored NCAM-120 in rabies virus infection. (17208489)
2007
50
Efficacy study of a new albumin-free human diploid cell rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai patients. (7483780)
1995

Variations for Rabies

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Expression for genes affiliated with Rabies

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rabies

Search GEO for disease gene expression data for Rabies.

Pathways for genes affiliated with Rabies

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 56Reactome
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Pathways related to Rabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4MPZ, HLA-G
2
Show member pathways
9.0MX1, HLA-G

Compounds for genes affiliated with Rabies

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Rabies according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1sulfatide469.9MPZ, ITIH4
2glycolipid469.8ITIH4, MPZ
3sorafenib46 52 1211.6ITIH4, AIFM1
4ganglioside469.6ITIH4, MPZ
5curcumin469.5MPZ, AIFM1
6biotin46 25 1211.5MPZ, ITIH4
7nmda46 3010.2AIFM1, SRR, ITIH4
8ifn-alpha469.1HLA-G, MX1
9urea46 25 1211.1ITIH4, HLA-G
10neopterin469.1MX1, HLA-G
11lactate469.1AIFM1, HLA-G, ITIH4
12glutamate468.8AIFM1, MPZ, SRR, ITIH4
13cysteine468.7ITIH4, MPZ, HLA-G, AIFM1
14lipid468.3AIFM1, HLA-G, MPZ, MX1
15serine468.0MX1, ITIH4, SRR, MPZ, AIFM1

GO Terms for genes affiliated with Rabies

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17Gene Ontology
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Cellular components related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.6ITIH4, IGHM
2plasma membraneGO:0058867.8ITIH4, SRR, MPZ, HLA-G, IGHM

Biological processes related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:0603379.0MX1, HLA-G

Products for genes affiliated with Rabies

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rabies

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet