MCID: RBS001
MIFTS: 57

Rabies malady

Rare diseases, Infectious diseases, Neuronal diseases categories

Summaries for Rabies

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MedlinePlus:34 Rabies is a deadly animal disease caused by a virus. it can happen in wild animals, including raccoons, skunks, bats and foxes, or in dogs, cats or farm animals. people get it from the bite of an infected animal. in people, symptoms of rabies include fever, headache and fatigue, then confusion, hallucinations and paralysis. once the symptoms begin, the disease is usually fatal. a series of shots can prevent rabies in people exposed to the virus. you need to get them right away. if an animal bites you, wash the wound well; then get medical care. to help prevent rabies vaccinate your pet. rabies vaccines are available for dogs, cats and farm animals don't let pets roam don't approach stray animals. animals with rabies might be aggressive and vicious, or tired and weak centers for disease control and prevention

MalaCards based summary: Rabies, also known as lyssa, is related to encephalitis and tetanus, and has symptoms including hallucinations, vocal cord paresis and diarrhea. An important gene associated with Rabies is IGHM (immunoglobulin heavy constant mu), and among its related pathways are Cell adhesion molecules (CAMs) and Immune response IFN alpha beta signaling pathway. The compounds sulfatide and glycolipid have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and spinal cord, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology:10 A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. the infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.

CDC:4 More

Wikipedia:65 Rabies is a viral disease that causes acute inflammation of the brain in humans and other warm-blooded... more...

Aliases & Classifications for Rabies

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 4CDC, 62UMLS, 57SNOMED-CT, 35MeSH, 29ICD9CM, 40NCIt, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Rabies, Aliases & Descriptions:

Name: Rabies 10 43 12 45 49 34 4 62
 
Lyssa 10 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
rabies:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology10 DOID:11260
MeSH35 D011818
ICD9CM29 071
NCIt40 C28182
Orphanet49 770
MESH via Orphanet36 D011818
ICD10 via Orphanet28 A82.0, A82.1, A82.9
UMLS via Orphanet63 C0034494
ICD1027 A82, A82.9

Related Diseases for Rabies

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Graphical network of the top 20 diseases related to Rabies:



Diseases related to rabies

Symptoms for Rabies

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Symptoms:

 49 10 (show all 29)
  • pharyngitis
  • hypersialorrhea
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • larynx/laryngeal palsy
  • facial pain/cephalalgia/migraine
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • insomnia
  • hyperactivity/attention deficit
  • psychic/behavioural troubles
  • delirium/hallucination
  • anorexia
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • fever/chilling
  • motor deficit/trouble
  • acute palsy
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • seizures/epilepsy/absences/spasms/status epilepticus
  • obnubilation/coma/lethargia/desorientation
  • fever
  • headache
  • prickling or itching sensation at the site of bite
  • anxiety
  • confusion
  • agitation
  • delirium
  • difficulty swallowing
  • hydrophobia
  • paralysis

HPO human phenotypes related to Rabies:

(show all 16)
id Description Frequency HPO Source Accession
1 hallucinations hallmark (90%) HP:0000738
2 vocal cord paresis hallmark (90%) HP:0001604
3 diarrhea hallmark (90%) HP:0002014
4 nausea and vomiting hallmark (90%) HP:0002017
5 anorexia hallmark (90%) HP:0002039
6 migraine hallmark (90%) HP:0002076
7 paresthesia hallmark (90%) HP:0003401
8 excessive salivation hallmark (90%) HP:0003781
9 abnormality of temperature regulation hallmark (90%) HP:0004370
10 attention deficit hyperactivity disorder hallmark (90%) HP:0007018
11 recurrent pharyngitis hallmark (90%) HP:0100776
12 insomnia hallmark (90%) HP:0100785
13 cerebral palsy typical (50%) HP:0100021
14 seizures occasional (7.5%) HP:0001250
15 sudden cardiac death occasional (7.5%) HP:0001645
16 reduced consciousness/confusion occasional (7.5%) HP:0004372

Drugs & Therapeutics for Rabies

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Drug clinical trials:

Search ClinicalTrials for Rabies

Search NIH Clinical Center for Rabies

Genetic Tests for Rabies

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Anatomical Context for Rabies

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MalaCards organs/tissues related to Rabies:

33
Brain, Spinal cord, Testes, Cortex, Skin, B cells, Eye, Lymph node, Lung, Monocytes, T cells, Dorsal root ganglion

FMA organs/tissues related to Rabies:

16
Brain or

Animal Models for Rabies or affiliated genes

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MGI Mouse Phenotypes related to Rabies:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0IGHM, HLA-G, MPZ, SRR, AIFM1
2MP:00053847.9ITIH4, SRR, MPZ, IGHM, AIFM1

Publications for Rabies

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Articles related to Rabies:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Concentration and purification of rabies viral and lentiviral vectors. (25834256)
2015
2
Role of dog sterilisation and vaccination in rabies control programmes. (25344046)
2014
3
Strategic model of national rabies control in Korea. (24427765)
2014
4
Rabies: Underused vaccines, unnecessary deaths. (24434045)
2014
5
Rabies surveillance in the United States during 2013. (25356711)
2014
6
A novel site-II directed glycoprotein estimation ELISA to aid rabies vaccine manufacture for veterinary and human use. (24262315)
2014
7
Development of a reverse genetics system for the aG strain of rabies virus in China. (24272786)
2013
8
Prioritization of capacities for the elimination of dog-mediated human rabies in the Americas: building the framework. (24392676)
2013
9
Rabies virus nucleoprotein expressed in silkworm pupae at high-levels and evaluation of immune responses in mice. (23178898)
2013
10
Characterization of street rabies virus variants with an additional N-glycan at position 247 in the glycoprotein. (23921623)
2013
11
Epidemiology of urban dog-related injuries requiring rabies post-exposure prophylaxis in Marseille, France. (23116608)
2013
12
Evaluation of an ELISA to detect rabies antibodies in orally vaccinated foxes and raccoon dogs sampled in the field. (23201293)
2013
13
Pre-exposure vaccination against rabies: are we being left in the lurch? (24123447)
2013
14
Making rabies prophylaxis more economical: Immunogenicity and safety results from a preliminary study using a 2-1 intramuscular regimen in healthy volunteers. (24008819)
2013
15
MRI in rabies encephalitis. (24172782)
2013
16
Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman Moore strain) manufactured in India. (24030586)
2013
17
Costs of rabies control: an economic calculation method applied to flores island. (24386244)
2013
18
Spatial epidemiology of bat-borne rabies in Colombia. (24096979)
2013
19
Gains and future road map for the elimination of dog-transmitted rabies in the americas. (24306030)
2013
20
The introduction of fox rabies into Italy (2008-2011) was due to two viral genetic groups with distinct phylogeographic patterns. (23603764)
2013
21
Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice. (23718883)
2013
22
Relationship between virus-neutralizing antibody levels and the number of rabies vaccinations: a prospective study of dogs in Japan. (23429079)
2013
23
WSAVA and OIE call for action on rabies. (24243670)
2013
24
Prevalence of rabies in various species in yemen and risk factors contributing to the spread of the disease. (23984026)
2013
25
Dog bite histories and response to incidents in canine rabies-enzootic KwaZulu-Natal, South Africa. (23593511)
2013
26
Recent emergence and spread of an Arctic-related phylogenetic lineage of rabies virus in Nepal. (24278494)
2013
27
Characterization of a wild rabies virus isolate of porcine origin in China. (23567821)
2013
28
Evidence-based control of canine rabies: a critical review of population density reduction. (23004351)
2013
29
Economic Evaluation of Vampire Bat (Desmodus rotundus) Rabies Prevention in Mexico. (22984914)
2012
30
Netherlands rabies case highlights importance of following pet travel rules. (22467819)
2012
31
Management of a wild animal bite in a rabies enzootic area. (22860504)
2012
32
Case report: Evidence of rise in rabies cases in southern Malawi--better preventative measures are urgently required. (23638276)
2012
33
Molecular characterization of the complete genome of a street rabies virus WH11 isolated from donkey in China. (22836559)
2012
34
Ecological and anthropogenic drivers of rabies exposure in vampire bats: implications for transmission and control. (22696521)
2012
35
Rabies after corneal transplantation: non-canine rabies and eye banking. (23278792)
2012
36
First human rabies case in French Guiana, 2008: epidemiological investigation and control. (22363830)
2012
37
Susceptibility and lack of evidence for a viremic state of rabies in the night owl monkey, Aotus nancymaae. (22612895)
2012
38
History of Rabies in Traditional Medicine's Resources and Iranian Research Studies: On the CccasiOn of the World Rabies Day (September 28, 2012). (23024845)
2012
39
Small interfering RNAs targeting the rabies virus nucleoprotein gene. (22884777)
2012
40
Request for pictures of rabies vaccine bait. (22435125)
2012
41
Post-exposure prophylaxis against rabies at two newly designated intradermal rabies vaccination clinics in Kerala, India. (23448625)
2012
42
Resistance to rabies. (22855748)
2012
43
Passive immunity in the prevention of rabies. (22541629)
2012
44
Moving from rabies research to rabies control: lessons from India. (22880139)
2012
45
Ambivalent role of the innate immune response in rabies virus pathogenesis. (21525357)
2011
46
Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. (21632762)
2011
47
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. (19247444)
2009
48
The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. (17287281)
2007
49
Role of GPI-anchored NCAM-120 in rabies virus infection. (17208489)
2007
50
Efficacy study of a new albumin-free human diploid cell rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai patients. (7483780)
1995

Variations for Rabies

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Expression for genes affiliated with Rabies

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Search GEO for disease gene expression data for Rabies.

Pathways for genes affiliated with Rabies

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Pathways related to Rabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4MPZ, HLA-G
2
Show member pathways
9.0MX1, HLA-G

Compounds for genes affiliated with Rabies

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Sources:
45Novoseek, 51PharmGKB, 13DrugBank, 26HMDB, 30IUPHAR
See all sources

Compounds related to Rabies according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1sulfatide459.9MPZ, ITIH4
2glycolipid459.8ITIH4, MPZ
3sorafenib45 51 1311.6ITIH4, AIFM1
4ganglioside459.6ITIH4, MPZ
5curcumin459.5MPZ, AIFM1
6biotin45 26 1311.5MPZ, ITIH4
7nmda45 3010.2AIFM1, SRR, ITIH4
8ifn-alpha459.1HLA-G, MX1
9urea45 26 1311.1ITIH4, HLA-G
10neopterin459.1MX1, HLA-G
11lactate459.1AIFM1, HLA-G, ITIH4
12glutamate458.8AIFM1, MPZ, SRR, ITIH4
13cysteine458.7ITIH4, MPZ, HLA-G, AIFM1
14lipid458.3AIFM1, HLA-G, MPZ, MX1
15serine458.0MX1, ITIH4, SRR, MPZ, AIFM1

GO Terms for genes affiliated with Rabies

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Cellular components related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.6ITIH4, IGHM
2plasma membraneGO:00058867.8ITIH4, SRR, MPZ, HLA-G, IGHM

Biological processes related to Rabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:00603379.0MX1, HLA-G

Products for genes affiliated with Rabies

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Rabies

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet