RMS
MCID: RBS003
MIFTS: 55

Rabson-Mendenhall Syndrome (RMS) malady

Categories: Genetic diseases, Rare diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Rabson-Mendenhall Syndrome

Aliases & Descriptions for Rabson-Mendenhall Syndrome:

Name: Rabson-Mendenhall Syndrome 54 50 24 25 56 66 13 52 69
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities 54 50 24 25
Mendenhall Syndrome 50 25 66
Pineal Hyperplasia and Diabetes Mellitus Syndrome 25 29
Rms 25 66

Characteristics:

Orphanet epidemiological data:

56
rabson-mendenhall syndrome
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal;

HPO:

32
rabson-mendenhall syndrome:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 262190
Orphanet 56 ORPHA769
MESH via Orphanet 43 D056731
UMLS via Orphanet 70 C0271695
ICD10 via Orphanet 34 E13
MedGen 40 C0271695

Summaries for Rabson-Mendenhall Syndrome

NIH Rare Diseases : 50 rabson-mendenhall syndrome is a genetic disorder characterized by severe insulin resistance. insulin, a hormone produced by the pancreas, regulates blood sugar levels by promoting the movement of glucose into cells for energy production or into the liver and fat cells for storage. symptoms of rabson-mendenhall syndrome may include intrauterine and postnatal growth retardation, hypertrophy of muscle and fat tissues, abnormalities of the head and face, abnormalities of the teeth and nails, and skin abnormalities such as acanthosis nigricans. additional symptoms may also be present. rabson-mendenhall syndrome is inherited in an autosomal recessive manner. treatment is difficult and may include high doses of insulin and/or recombinant insulin-like growth factor. last updated: 11/9/2010

MalaCards based summary : Rabson-Mendenhall Syndrome, also known as pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities, is related to rhabdomyosarcoma and large cell carcinoma with rhabdoid phenotype, and has symptoms including dry skin, diabetes mellitus and precocious puberty. An important gene associated with Rabson-Mendenhall Syndrome is INSR (Insulin Receptor), and among its related pathways/superpathways are TGF-Beta Pathway and p70S6K Signaling. The drugs Zinc and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include pineal, skin and liver, and related phenotypes are Decreased substrate adherent cell growth and adipose tissue

Genetics Home Reference : 25 Rabson-Mendenhall syndrome is a rare disorder characterized by severe insulin resistance, a condition in which the body's tissues and organs do not respond properly to the hormone insulin. Insulin normally helps regulate blood sugar levels by controlling how much sugar (in the form of glucose) is passed from the bloodstream into cells to be used as energy. In people with Rabson-Mendenhall syndrome, insulin resistance impairs blood sugar regulation and ultimately leads to a condition called diabetes mellitus, in which blood sugar levels can become dangerously high.

UniProtKB/Swiss-Prot : 66 Rabson-Mendenhall syndrome: Severe insulin resistance syndrome characterized by insulin-resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive.

Description from OMIM: 262190

Related Diseases for Rabson-Mendenhall Syndrome

Diseases related to Rabson-Mendenhall Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 11.6
2 large cell carcinoma with rhabdoid phenotype 10.8
3 medullary sponge kidney 10.3
4 insulin-like growth factor i 10.3
5 intellectual disability-developmental delay-contractures syndrome 10.2 INS INSR
6 hepatitis 10.1
7 cerebritis 10.1
8 diabetic cataract 10.1 INS INSR
9 femur bifid with monodactylous ectrodactyly 10.1 IGF1 INSR
10 sohval soffer syndrome 10.1 IGF1 IGFBP3
11 microtia, hearing impairment, and cleft palate 10.1 IGF1 IGFBP3
12 spondylometaphyseal dysplasia, megarbane-dagher-melike type 10.1 IGF1 IGFBP3
13 capgras syndrome 10.1 IGF1 IGFBP3
14 dacryoadenitis 10.1 IGF1 INS
15 pituitary adenoma, acth-secreting 10.1 IGF1 IGFBP3
16 epileptic encephalopathy, early infantile, 24 10.1 IGF1 IGFBP3
17 tmem231-related joubert syndrome 10.1 IGF1 INS
18 phacolytic glaucoma 10.1 IGF1 IGFBP3
19 brucella canis brucellosis 10.1 IGF1 INS
20 mental retardation, autosomal recessive 35 10.1 IGF1 IGFBP3
21 epidural spinal canal meningioma 10.1 IGF1 INS
22 neurogenic arthropathy 10.0 IGF1 INS
23 gynandroblastoma 10.0 IGF1 IGFBP3
24 post-traumatic stress disorder 10.0 IGF1 IGFBP3
25 urethra clear cell adenocarcinoma 10.0 IGF1 INS
26 ehlers-danlos syndrome, cardiac valvular form 10.0 IGF1 IGFBP3
27 papillary craniopharyngioma 10.0 IGF1 INS
28 chondroma 10.0 IGF1 INS
29 aflatoxins-related hepatocellular carcinoma 10.0 IGF1 INS
30 embryonal rhabdomyosarcoma 10.0
31 capillary lymphangioma 10.0 IGF1 INS
32 ganglioneuroblastoma 10.0 IGF1R INSR
33 vernal conjunctivitis 10.0 IGF1 INS
34 congenital symblepharon 10.0 IGF1 IGFBP3
35 central nervous system leiomyoma 10.0 IGF1 IGFBP3
36 microphthalmia 10.0 IGF1R IGFBP3
37 limb ischemia 10.0 IGF1 INS
38 coronary aneurysm 10.0 IGF1R IGFBP3
39 albinism, oculocutaneous, type ib 10.0 IGF1 IGFBP3
40 argininosuccinic aciduria 10.0 IGF1 IGFBP3
41 diabetic encephalopathy 9.9 IGF1 INS
42 extrahepatic bile duct adenocarcinoma 9.9 IGF1 IGFBP3
43 necrobiosis lipoidica 9.9 IGF1 IGFBP3
44 pelvic muscle wasting 9.9 IGF1 INS INSR
45 blind loop syndrome 9.9 IGF1 INS INSR
46 primary biliary cirrhosis 9.9 IGF1 INS INSR
47 brain stem glioma 9.9 IGF1 INS INSR
48 seow najjar syndrome 9.9 IGF1 IGFBP3 INS
49 protein s deficiency 9.9 IGF1 IGFBP3 INS
50 gerstmann syndrome 9.9 IGF1 IGFBP3 INS

Graphical network of the top 20 diseases related to Rabson-Mendenhall Syndrome:



Diseases related to Rabson-Mendenhall Syndrome

Symptoms & Phenotypes for Rabson-Mendenhall Syndrome

Symptoms by clinical synopsis from OMIM:

262190

Clinical features from OMIM:

262190

Human phenotypes related to Rabson-Mendenhall Syndrome:

56 32 (show all 38)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 56 32 Frequent (79-30%) HP:0000958
2 diabetes mellitus 56 32 Very frequent (99-80%) HP:0000819
3 precocious puberty 56 32 Frequent (79-30%) HP:0000826
4 coarse facial features 56 32 Very frequent (99-80%) HP:0000280
5 mandibular prognathia 56 32 Very frequent (99-80%) HP:0000303
6 coarse hair 56 32 Frequent (79-30%) HP:0002208
7 short stature 56 32 Frequent (79-30%) HP:0004322
8 proteinuria 56 32 Frequent (79-30%) HP:0000093
9 acanthosis nigricans 56 32 Very frequent (99-80%) HP:0000956
10 peripheral neuropathy 56 32 Frequent (79-30%) HP:0009830
11 generalized hirsutism 56 32 Very frequent (99-80%) HP:0002230
12 abnormality of the upper urinary tract 56 32 Occasional (29-5%) HP:0010935
13 intrauterine growth retardation 56 32 Very frequent (99-80%) HP:0001511
14 polycystic ovaries 56 32 Occasional (29-5%) HP:0000147
15 prematurely aged appearance 56 32 Frequent (79-30%) HP:0007495
16 brachydactyly syndrome 56 32 Frequent (79-30%) HP:0001156
17 growth hormone excess 56 32 Very frequent (99-80%) HP:0000845
18 long penis 56 32 Very frequent (99-80%) HP:0000040
19 female pseudohermaphroditism 56 32 Very frequent (99-80%) HP:0010458
20 abnormality of the thyroid gland 56 32 Frequent (79-30%) HP:0000820
21 advanced eruption of teeth 56 32 Very frequent (99-80%) HP:0006288
22 thick nail 56 32 Very frequent (99-80%) HP:0001805
23 abnormality of the abdominal wall 56 32 Very frequent (99-80%) HP:0004298
24 high palate 32 HP:0000218
25 global developmental delay 32 HP:0001263
26 abnormality of the teeth 56 Very frequent (99-80%)
27 hypoglycemia 32 HP:0001943
28 hyperinsulinemia 32 HP:0000842
29 thickened skin 56 Frequent (79-30%)
30 postprandial hyperglycemia 32 HP:0011998
31 insulin-resistant diabetes mellitus 32 HP:0000831
32 small for gestational age 32 HP:0001518
33 hyperglycemia 32 HP:0003074
34 fasting hypoglycemia 32 HP:0003162
35 clitoral hypertrophy 32 HP:0008665
36 hypertrichosis 32 HP:0000998
37 onychauxis 32 HP:0012542
38 diabetic ketoacidosis 32 HP:0001953

UMLS symptoms related to Rabson-Mendenhall Syndrome:


dry skin

GenomeRNAi Phenotypes related to Rabson-Mendenhall Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 IGF1R
2 Decreased substrate adherent cell growth GR00193-A-3 8.92 INSR
3 Decreased substrate adherent cell growth GR00193-A-4 8.92 IGF1R INSR

MGI Mouse Phenotypes related to Rabson-Mendenhall Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.77 IGF1 IGF1R IGFBP3 INS INSR
2 endocrine/exocrine gland MP:0005379 9.72 IGF1 IGF1R IGFBP3 INS INSR
3 growth/size/body region MP:0005378 9.65 IGF1 IGF1R IGFBP3 INS INSR
4 integument MP:0010771 9.46 IGF1 IGF1R IGFBP3 INS
5 liver/biliary system MP:0005370 9.26 IGF1R IGFBP3 INS INSR
6 muscle MP:0005369 9.02 IGF1R IGFBP3 INS INSR IGF1

Drugs & Therapeutics for Rabson-Mendenhall Syndrome

Drugs for Rabson-Mendenhall Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 2 7440-66-6 32051 23994
2 Hypoglycemic Agents Phase 2
3 insulin Phase 2
4 Insulin, Globin Zinc Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Leptin to Treat Severe Insulin Resistance - Pilot Study Completed NCT00027456 Phase 2
2 Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance Recruiting NCT00085982 Phase 2

Search NIH Clinical Center for Rabson-Mendenhall Syndrome

Genetic Tests for Rabson-Mendenhall Syndrome

Genetic tests related to Rabson-Mendenhall Syndrome:

id Genetic test Affiliating Genes
1 Pineal Hyperplasia and Diabetes Mellitus Syndrome 29
2 Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities 24 INSR

Anatomical Context for Rabson-Mendenhall Syndrome

MalaCards organs/tissues related to Rabson-Mendenhall Syndrome:

39
Pineal, Skin, Liver, Pancreas, Thyroid, Ovary, Kidney

Publications for Rabson-Mendenhall Syndrome

Articles related to Rabson-Mendenhall Syndrome:

(show all 32)
id Title Authors Year
1
Treatment of Diabetic Ketoacidosis With Intravenous U-500 Insulin in a Patient With Rabson-Mendenhall Syndrome: A Case Report. ( 27112737 )
2016
2
Identification of a Novel Homozygous INSR Variant in a Patient with Rabson-Mendenhall Syndrome from the United Arab Emirates. ( 27326825 )
2016
3
A novel homozygous missense mutation in the insulin receptor gene results in an atypical presentation of Rabson-Mendenhall syndrome. ( 26691667 )
2016
4
Rabson Mendenhall Syndrome caused by a novel missense mutation. ( 27891155 )
2016
5
Rabson-mendenhall syndrome. ( 25484423 )
2014
6
Renal manifestations of severe Rabson-Mendenhall syndrome: a case report. ( 23497647 )
2013
7
Rabson-Mendenhall syndrome with recurrent cerebral infarcts caused by a novel INSR mutation. ( 23347304 )
2013
8
Rabson-Mendenhall syndrome. ( 23263437 )
2012
9
A case of Rabson-Mendenhall syndrome with a novel mutation in the tyrosine kinase domain of the insulin receptor gene complicated by medullary sponge kidney. ( 22876563 )
2012
10
Two novel insulin receptor gene mutations in a patient with Rabson-Mendenhall syndrome: the first Korean case confirmed by biochemical, and molecular evidence. ( 22563226 )
2012
11
Functional characterization of insulin receptor gene mutations contributing to Rabson-Mendenhall syndrome - phenotypic heterogeneity of insulin receptor gene mutations. ( 21869538 )
2011
12
Multidrug therapy in a patient with Rabson-Mendenhall syndrome. ( 20711714 )
2010
13
Long survival in Rabson-Mendenhall syndrome. ( 20627358 )
2010
14
Rabson-Mendenhall syndrome: two case reports and a brief review of the literature. ( 20155514 )
2010
15
Fibroepithelial papillomatosis ("skin tags") in Rabson-Mendenhall syndrome. ( 18405695 )
2008
16
Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. ( 18411068 )
2008
17
Rabson-Mendenhall syndrome. ( 18717867 )
2008
18
Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome. ( 17201797 )
2007
19
Rabson-Mendenhall syndrome: medullary sponge kidney, a new component. ( 17849153 )
2007
20
Rabson-Mendenhall syndrome. ( 15738613 )
2005
21
Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome. ( 15070911 )
2004
22
Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective. ( 15232309 )
2004
23
What syndrome is this? Rabson-Mendenhall syndrome. ( 12047650 )
2002
24
Decreased half-life of insulin-like growth factor I in Rabson-Mendenhall syndrome. ( 11757582 )
2001
25
Defective insulin receptors in Rabson-Mendenhall syndrome cause complete peripheral insulin resistance but minimal hepatic insulin response remains. ( 15016231 )
2000
26
Progressive decline in insulin levels in Rabson-Mendenhall syndrome. ( 10443650 )
1999
27
Major circadian variations of glucose homeostasis in a patient with Rabson-Mendenhall syndrome and primary insulin resistance due to a mutation (Cys284-->Tyr) in the insulin receptor alpha-subunit. ( 9212040 )
1997
28
[Rabson-Mendenhall syndrome]. ( 7983791 )
1994
29
Impaired growth in Rabson-Mendenhall syndrome: lack of effect of growth hormone and insulin-like growth factor-I. ( 8077364 )
1994
30
An in-frame insertion in exon 3 and a nonsense mutation in exon 2 of the insulin receptor gene associated with severe insulin resistance in a patient with Rabson-Mendenhall syndrome. ( 8270132 )
1993
31
Insulin-receptor biosynthesis in cultured lymphocytes from an insulin-resistant patient (Rabson-Mendenhall syndrome). Evidence for defect before insertion of receptor into plasma membrane. ( 3721065 )
1986
32
Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts. ( 6339538 )
1983

Variations for Rabson-Mendenhall Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Rabson-Mendenhall Syndrome:

66
id Symbol AA change Variation ID SNP ID
1 INSR p.Asn42Lys VAR_004079 rs121913143
2 INSR p.His236Arg VAR_004084 rs121913145
3 INSR p.Ser350Leu VAR_015914
4 INSR p.Pro997Thr VAR_015921
5 INSR p.Ile1143Thr VAR_015926
6 INSR p.Arg1158Trp VAR_015928 rs111993466
7 INSR p.Arg1201Trp VAR_015930
8 INSR p.Gly386Ser VAR_031520 rs764221583

ClinVar genetic disease variations for Rabson-Mendenhall Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 INSR NM_000208.3(INSR): c.126C> A (p.Asn42Lys) single nucleotide variant Pathogenic rs121913143 GRCh37 Chromosome 19, 7267882: 7267882
2 INSR NM_000208.3(INSR): c.3079C> T (p.Arg1027Ter) single nucleotide variant Pathogenic rs121913144 GRCh37 Chromosome 19, 7125473: 7125473
3 INSR NM_000208.3(INSR): c.1124-2A> G single nucleotide variant Pathogenic rs587776819 GRCh38 Chromosome 19, 7172436: 7172436
4 INSR NM_000208.3(INSR): c.2480_2487delAGGACACC (p.Gln827Profs) deletion Pathogenic rs587776820 GRCh38 Chromosome 19, 7142871: 7142878
5 INSR NM_000208.3(INSR): c.394G> A (p.Gly132Ser) single nucleotide variant Pathogenic rs886037750 GRCh37 Chromosome 19, 7267614: 7267614

Expression for Rabson-Mendenhall Syndrome

Search GEO for disease gene expression data for Rabson-Mendenhall Syndrome.

Pathways for Rabson-Mendenhall Syndrome

Pathways related to Rabson-Mendenhall Syndrome according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 IGF1 IGF1R INS INSR
2
Show member pathways
12.74 IGF1 IGF1R INS INSR
3
Show member pathways
12.59 IGF1 IGF1R INSR
4
Show member pathways
12.54 IGF1 IGF1R IGFBP3 INS INSR
5
Show member pathways
12.45 IGF1 IGF1R INS INSR
6 12.33 IGF1 IGF1R INS INSR
7
Show member pathways
12.27 IGF1R INS INSR
8
Show member pathways
12.25 IGF1 IGF1R INS INSR
9 12.22 IGF1R IGFBP3 INS INSR
10
Show member pathways
12.15 IGF1 IGF1R IGFBP3
11
Show member pathways
12.15 IGF1 IGF1R INS INSR
12
Show member pathways
12.1 IGF1 IGF1R INS
13
Show member pathways
12.07 IGF1 IGF1R INSR
14 11.98 IGF1 IGF1R IGFBP3
15
Show member pathways
11.81 IGF1R INS INSR
16
Show member pathways
11.8 IGF1 IGF1R INS INSR
17
Show member pathways
11.7 IGF1 IGF1R INS INSR
18 11.68 IGF1 IGFBP3 INS
19
Show member pathways
11.66 INS INSR
20 11.53 IGF1R INSR
21 11.49 INS INSR
22 11.49 IGF1 IGF1R INSR
23 11.48 IGF1 IGF1R
24 11.48 IGF1 IGF1R IGFBP3 INS
25 11.45 IGF1 IGF1R
26 11.44 IGF1 IGF1R
27 11.39 INS INSR
28 11.37 IGF1 INS
29 11.35 INS INSR
30 11.32 IGF1 INS
31 11.29 IGF1R INSR
32 11.27 INS INSR
33
Show member pathways
11.25 INS INSR
34 11.25 IGF1 IGF1R INS INSR
35 11.15 IGF1 INS INSR
36 11.1 INS INSR
37 11.1 IGF1 IGF1R
38 11.07 INS INSR
39
Show member pathways
11.01 IGF1 IGF1R
40 10.9 IGF1 IGFBP3
41 10.62 IGF1 IGF1R INS INSR

GO Terms for Rabson-Mendenhall Syndrome

Cellular components related to Rabson-Mendenhall Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 9.16 IGF1 IGFBP3
2 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.96 IGF1 IGF1R
3 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Rabson-Mendenhall Syndrome according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 IGF1 IGF1R INS INSR
2 cellular protein metabolic process GO:0044267 9.71 IGF1 IGFBP3 INS
3 positive regulation of cell migration GO:0030335 9.71 IGF1 IGF1R INS INSR
4 insulin receptor signaling pathway GO:0008286 9.63 IGF1R INS INSR
5 positive regulation of glucose import GO:0046326 9.61 IGF1 INS INSR
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.59 IGF1 INS
7 positive regulation of protein kinase B signaling GO:0051897 9.58 INS INSR
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 IGF1 INS
9 peptidyl-tyrosine autophosphorylation GO:0038083 9.57 IGF1R INSR
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 INS INSR
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.55 IGF1 IGF1R
12 activation of protein kinase B activity GO:0032148 9.54 IGF1 INS INSR
13 insulin-like growth factor receptor signaling pathway GO:0048009 9.52 IGF1 IGF1R
14 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.51 IGF1 IGFBP3
15 positive regulation of mitotic nuclear division GO:0045840 9.5 IGF1 INS INSR
16 positive regulation of respiratory burst GO:0060267 9.48 INS INSR
17 positive regulation of glycogen biosynthetic process GO:0045725 9.43 IGF1 INS INSR
18 positive regulation of glycolytic process GO:0045821 9.33 IGF1 INS INSR
19 positive regulation of MAPK cascade GO:0043410 9.26 IGF1 IGFBP3 INS INSR
20 positive regulation of DNA replication GO:0045740 8.92 IGF1 IGF1R INS INSR

Molecular functions related to Rabson-Mendenhall Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 IGF1R INSR
2 insulin-like growth factor binding GO:0005520 9.43 IGF1R IGFBP3
3 phosphatidylinositol 3-kinase binding GO:0043548 9.4 IGF1R INSR
4 insulin receptor substrate binding GO:0043560 9.37 IGF1R INSR
5 insulin receptor binding GO:0005158 9.33 IGF1 IGF1R INS
6 insulin-like growth factor II binding GO:0031995 9.32 IGFBP3 INSR
7 insulin binding GO:0043559 9.26 IGF1R INSR
8 insulin-like growth factor receptor binding GO:0005159 9.13 IGF1 INS INSR
9 insulin-like growth factor I binding GO:0031994 8.8 IGF1R IGFBP3 INSR

Sources for Rabson-Mendenhall Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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