MCID: RDT001
MIFTS: 35

Radiation Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Radiation Cystitis

MalaCards integrated aliases for Radiation Cystitis:

Name: Radiation Cystitis 12 14
Irradiation Cystitis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7127
ICD10 33 N30.4
ICD9CM 35 595.82
NCIt 47 C123174
SNOMED-CT 64 11251000
UMLS 69 C0156270

Summaries for Radiation Cystitis

MalaCards based summary : Radiation Cystitis, also known as irradiation cystitis, is related to posterior mediastinum cancer and fibular collateral ligament bursitis. An important gene associated with Radiation Cystitis is UPK3A (Uroplakin 3A), and among its related pathways/superpathways are Apoptosis Pathway and Development and heterogeneity of the ILC family. The drugs Cyclophosphamide and Busulfan have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone marrow and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Radiation Cystitis

Diseases related to Radiation Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 posterior mediastinum cancer 10.7 KLK3 MAPK8IP1
2 fibular collateral ligament bursitis 10.6 KLK3 UPK3A
3 cystitis 10.5
4 anterograde amnesia 10.4 KANTR KLK3
5 right bundle branch block 10.4 F7 KANTR
6 munchausen by proxy 10.4 KLK3 NOS1
7 cytoplasmic body myopathy 10.4 IL13 IL5
8 hypochondriasis 10.4 KANTR KLK3
9 aortic arch interruption 10.4 IL13 IL5
10 hypercementosis 10.4 IL13 IL5
11 toxic diffuse goiter 10.4 IL13 IL5
12 dioctophymiasis 10.3 IL13 IL5
13 cholesteatoma of middle ear 10.3 IL13 IL5
14 winchester syndrome 10.3 IL13 IL5
15 central nervous system germ cell tumor 10.3 F7 KANTR
16 cherry allergy 10.3 IL13 IL5
17 epididymis adenocarcinoma 10.3 IL13 IL5
18 diffuse alopecia areata 10.3 F7 KANTR
19 myofibroma 10.3 IL13 IL5
20 uterine inversion 10.3 KANTR MAPK8IP1
21 hole retinal cyst 10.3 KDR KLK3
22 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.3 IL13 IL5
23 purpura fulminans 10.3 IL13 IL5
24 fungal gastritis 10.3 IL13 IL5
25 pituitary carcinoma 10.3 ATM KLK3 UPK3A
26 abdominal tuberculosis 10.3 IL13 IL5
27 glycogen-rich clear cell breast carcinoma 10.3 ATM KLK3 UPK3A
28 breast adenomyoepithelial adenosis 10.3 ATM KLK3 UPK3A
29 acute gonococcal prostatitis 10.3 IL13 IL5
30 trachea leiomyoma 10.2 IL13 IL5
31 exudative vitreoretinopathy 2, x-linked 10.2 IL13 IL5
32 glucose intolerance 10.2 IL13 IL5
33 viljoen kallis voges syndrome 10.2 IL13 IL5
34 myofascial pain syndrome 10.1 IL13 IL5
35 autoimmune neuropathy 10.1 IL13 IL5
36 skin amelanotic melanoma 10.0 ATM HMOX1
37 angiomyoma 10.0 IL13 IL5
38 brain glioblastoma multiforme 9.9 KLK3 NME1-NME2 UPK3A
39 spindle cell variant squamous cell breast carcinoma 9.9 IL13 IL5
40 frontal sinus schneiderian papilloma 9.9 IL13 IL5 KANTR
41 differentiating neuroblastoma 9.8 ATM KDR
42 proctitis 9.8
43 prostate cancer 9.7
44 prostatitis 9.7
45 cervicitis 9.7
46 facial dermatosis 9.6 KDR KLK3
47 colitis 9.6
48 neurogenic bladder 9.6
49 interstitial cystitis 9.6
50 thyroiditis 9.6

Comorbidity relations with Radiation Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Bladder Neck Obstruction Cystitis
Deficiency Anemia Hydronephrosis
Intestinal Obstruction Prostate Cancer
Urethral Stricture Urinary Bladder Cancer

Graphical network of the top 20 diseases related to Radiation Cystitis:



Diseases related to Radiation Cystitis

Symptoms & Phenotypes for Radiation Cystitis

MGI Mouse Phenotypes related to Radiation Cystitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ATM F7 GATM HMOX1 IL13 IL5
2 growth/size/body region MP:0005378 9.97 ATM F7 GATM HMOX1 IL13 IL5
3 adipose tissue MP:0005375 9.77 GATM HMOX1 NOS1 ATM F7
4 liver/biliary system MP:0005370 9.63 IL5 KDR MAPK8IP1 NOS1 GATM HMOX1
5 muscle MP:0005369 9.43 GATM HMOX1 IL13 KDR NOS1 TCAP
6 reproductive system MP:0005389 9.17 ATM GATM HMOX1 IL13 IL5 MAPK8IP1

Drugs & Therapeutics for Radiation Cystitis

Drugs for Radiation Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
2
Busulfan Approved, Investigational Phase 3 55-98-1 2478
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Mesna Approved Phase 3 3375-50-6 598
5
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
9 Antirheumatic Agents Phase 3,Phase 2
10 Alkylating Agents Phase 3
11 Antifungal Agents Phase 3
12 Anti-Infective Agents Phase 3
13 Antimetabolites Phase 3
14 Antimetabolites, Antineoplastic Phase 3
15 Antineoplastic Agents, Phytogenic Phase 3
16
Bilirubin Phase 3 635-65-4 5280352
17 Calcineurin Inhibitors Phase 3
18 Cyclosporins Phase 3
19 Dermatologic Agents Phase 3
20 Etoposide phosphate Phase 3
21 Folic Acid Antagonists Phase 3
22 Immunosuppressive Agents Phase 3
23 Nucleic Acid Synthesis Inhibitors Phase 3
24 Protective Agents Phase 3
25 Topoisomerase Inhibitors Phase 3
26 Vitamin B Complex Phase 3
27 Folate Nutraceutical Phase 3
28 Vitamin B9 Nutraceutical Phase 3
29
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
30
Curcumin Investigational Phase 2 458-37-7 969516
31 Analgesics Phase 2
32 Analgesics, Non-Narcotic Phase 2
33 Anti-Inflammatory Agents Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Peripheral Nervous System Agents Phase 2
36
Epinephrine Approved, Vet_approved 51-43-4 5816
37 Racepinephrine Approved
38 Epinephryl borate

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Recruiting NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
2 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
3 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
4 Ion Prostate Irradiation Completed NCT01641185 Phase 2
5 Total Body Irradiation/Fludarabine Based Ablative Haploidentical Transplant for Hematologic Diseases Completed NCT01336712 Phase 2
6 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
7 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
8 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
9 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder Recruiting NCT03143920 Early Phase 1
10 HBOT Late Radiation Tissue Injury Recruiting NCT02425215

Search NIH Clinical Center for Radiation Cystitis

Genetic Tests for Radiation Cystitis

Anatomical Context for Radiation Cystitis

MalaCards organs/tissues related to Radiation Cystitis:

39
Prostate, Bone Marrow, Bone, Cervix, Thyroid, Uterus

Publications for Radiation Cystitis

Articles related to Radiation Cystitis:

(show top 50) (show all 62)
id Title Authors Year
1
Ureteral Embolization to Prevent Thrombotic Obstruction of Nephrostomy Catheters in the Context of Refractory Hemorrhagic Radiation Cystitis with Severe Vesicoureteral Reflux. ( 27019759 )
2016
2
Hyperbaric Oxygen Therapy for Radiation Cystitis. ( 27637115 )
2016
3
A Narrative Review on the Pathophysiology and Management for Radiation Cystitis. ( 26798335 )
2015
4
Sodium hyaluronate and chondroitin sulfate replenishment therapy can improve nocturia in men with post-radiation cystitis: results of a prospective pilot study. ( 26148853 )
2015
5
Modeling and Treatment of Radiation Cystitis. ( 26571081 )
2015
6
Intravesical Liposomal Tacrolimus Protects Against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation. ( 25839382 )
2015
7
Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. ( 26347076 )
2015
8
Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double blinded, placebo controlled pilot study. ( 24993395 )
2014
9
Early urinary diversion with ileal conduit and vesicovaginostomy in the treatment of radiation cystitis due to carcinoma cervix: a study from a tertiary care hospital in South India. ( 25366250 )
2014
10
Advances in Therapeutic Development for Radiation Cystitis. ( 26663493 )
2014
11
Successful use of endoscopic argon plasma coagulation for hemorrhagic radiation cystitis: a case report. ( 24837598 )
2014
12
Hyperbaric oxygen therapy for hemorrhagic radiation cystitis. ( 23516773 )
2013
13
Hyperbaric oxygen therapy for hemorrhagic radiation cystitis. ( 23516766 )
2013
14
Radiation cystitis with pseudocarcinomatous urothelial hyperplasia. ( 24045222 )
2013
15
Hemorrhagic Radiation Cystitis. ( 24322335 )
2013
16
Evaluation of the impact of the urinary symptoms on quality of life of patients with painful bladder syndrome/chronic pelvic pain and radiation cystitis: EURCIS study. ( 24360594 )
2013
17
Possible risk factors associated with radiation proctitis or radiation cystitis in patients with cervical carcinoma after radiotherapy. ( 23464440 )
2012
18
A cost-analysis case study of radiation cystitis treatment including hyperbaric oxygen therapy. ( 22828818 )
2012
19
Hyperbaric oxygen therapy for radiation cystitis in patients with prostate cancer: a long-term follow-up study. ( 22797611 )
2012
20
Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies. ( 21365332 )
2011
21
Vascular therapy for radiation cystitis. ( 21412823 )
2011
22
Treatment of acute radiation cystitis: comment. ( 21739326 )
2011
23
Is treatment of hemorrhagic radiation cystitis with hyperbaric oxygen effective? ( 20224264 )
2010
24
Recombinant activated factor VII to control life-threatening haemorrhagic radiation cystitis. ( 19352582 )
2010
25
Efficacy of sodium hyaluronate in the management of chemical and radiation cystitis. ( 20562794 )
2010
26
Management of radiation cystitis. ( 20212517 )
2010
27
Radiation cystitis. ( 19625037 )
2009
28
Radiation cystitis: indication for hyperbaric oxygen. ( 18325711 )
2009
29
A new minimally invasive technique for treating radiation cystitis: the argon-beam coagulator. ( 16925761 )
2006
30
A phase II study to evaluate WF10 in patients with late hemorrhagic radiation cystitis and proctitis. ( 16169580 )
2006
31
Sexual function after partial cystectomy and urothelial stripping in a 32-year-old woman with radiation cystitis. ( 15647882 )
2005
32
Reduced recurrence of late hemorrhagic radiation cystitis by WF10 therapy in cervical cancer patients: a multicenter, randomized, two-arm, open-label trial. ( 15542165 )
2004
33
Rupture of urachal diverticulum in radiation cystitis and neurogenic bladder dysfunction after radical hysterectomy. ( 15479303 )
2004
34
Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis. ( 12137633 )
2002
35
Hyperbaric oxygen for the treatment of radiation cystitis and proctitis. ( 12084193 )
2002
36
Intravesicle formalin instillation with a modified technique for controlling haemorrhage secondary to radiation cystitis. ( 12376221 )
2002
37
Successful treatment of radiation cystitis with hyperbaric oxygen therapy: resolution of bleeding event and changes of histopathological findings of the bladder mucosa. ( 9696331 )
1998
38
Endoscopic topical placement of formalin soaked pledgets to control localized hemorrhage due to radiation cystitis. ( 9224340 )
1997
39
Effective hyperbaric oxygenation with prostaglandin E1 for radiation cystitis and colitis after pelvic radiotherapy. ( 9061423 )
1996
40
Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. ( 7674746 )
1995
41
Abnormal sensitivity to intravesical potassium in interstitial cystitis and radiation cystitis. ( 7833969 )
1994
42
Hyperbaric oxygen therapy in hemorrhagic radiation cystitis: a report of 20 cases. ( 7950806 )
1994
43
Bladder peptic ulcer after gastrocystoplasty for radiation cystitis. ( 8015094 )
1994
44
Hyperbaric oxygen treatment of radiation cystitis. ( 8324997 )
1993
45
Management of severe chronic radiation cystitis. ( 1416787 )
1992
46
Successful hyperbaric oxygenation for radiation cystitis due to excessive irradiation to uterus cancer. ( 1490506 )
1992
47
Control of persistent vesical bleeding due to radiation cystitis by intravesical application of 15 (S) 15-methyl prostaglandin F2-alpha. ( 2592003 )
1989
48
Successful treatment of radiation cystitis with hyperbaric oxygen. ( 2776806 )
1989
49
Control of massive vesical hemorrhage due to radiation cystitis with intravesical instillation of 15 (s) 15-methyl prostaglandin F2-alpha. ( 3235213 )
1988
50
Successful management of radiation cystitis with sodium pentosanpolysulfate. ( 2428986 )
1986

Variations for Radiation Cystitis

Expression for Radiation Cystitis

Search GEO for disease gene expression data for Radiation Cystitis.

Pathways for Radiation Cystitis

Pathways related to Radiation Cystitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.68 ATM IL13 IL5 KDR
2 10.87 IL13 IL5
3 10.8 IL13 IL5
4 10.67 IL13 IL5
5 10.6 HMOX1 IL13 IL5
6 10.33 IL13 IL5

GO Terms for Radiation Cystitis

Biological processes related to Radiation Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of endothelial cell apoptotic process GO:2000352 9.26 IL13 KDR
2 positive regulation of macroautophagy GO:0016239 9.16 HMOX1 KDR
3 positive regulation of positive chemotaxis GO:0050927 8.96 F7 KDR
4 response to hypoxia GO:0001666 8.92 ATM F7 HMOX1 NOS1

Sources for Radiation Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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