MCID: RDT005
MIFTS: 27

Radiation Induced Cancer malady

Cancer category

Summaries for Radiation Induced Cancer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Up to 10% of invasive cancers are related to radiation exposure, including both ionizing radiation and... more...

MalaCards: Radiation Induced Cancer, also known as radiation-induced cancer, is related to thyroid cancer and crohn's disease. An important gene associated with Radiation Induced Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are DNA Damage and Chks in Checkpoint Regulation. The compounds oligonucleotide and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and kidney.

Aliases & Classifications for Radiation Induced Cancer

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

radiation induced cancer 43
radiation-induced cancer 45 61
radiation related cancer 43


Related Diseases for Radiation Induced Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Radiation Induced Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer10.2
2crohn's disease10.1
3cockayne syndrome10.1
4cystic fibrosis10.1
5childhood medulloblastoma10.1
6spinal cancer10.1
7squamous cell carcinoma10.1
8testicular cancer10.1
9skin cancer10.0XPC
10ataxia telangiectasia10.0BRCA1
11fanconi's anemia10.0BRCA1
12li-fraumeni syndrome10.0XPC, BRCA1
13xeroderma pigmentosum10.0XPC, BRCA1
14astrocytoma10.0XPC, BRCA1
15bladder carcinoma10.0XPC, BRCA1

Graphical network of diseases related to Radiation Induced Cancer:



Diseases related to radiation induced cancer

Clinical Features for Radiation Induced Cancer

Drugs & Therapeutics for Radiation Induced Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Radiation Induced Cancer

Drug clinical trials:

Search ClinicalTrials for Radiation Induced Cancer

Search NIH Clinical Center for Radiation Induced Cancer

Search CenterWatch for Radiation Induced Cancer

Genetic Tests for Radiation Induced Cancer

Anatomical Context for Radiation Induced Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Radiation Induced Cancer:

33
Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Breast, Skin, Prostate, Monocytes, T cells, B cells, Tongue

Animal Models for Radiation Induced Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Radiation Induced Cancer

Sources:
51PubMed
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Articles related to Radiation Induced Cancer:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
How is the risk of radiation-induced cancer influenced by background risk factors? Invited commentary on "a method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure" by Walsh and Schneider (2012). (23180111)
2013
2
Body CT scanning in young adults: examination indications, patient outcomes, and risk of radiation-induced cancer. (23386731)
2013
3
Differentiation of tumor recurrence from radiation-induced pulmonary fibrosis after stereotactic ablative radiotherapy for lung cancer: characterization of 18F-FDG PET/CT findings. (23299492)
2013
4
Intravesical instillations with polydeoxyribonucleotides reduce symptoms of radiation-induced cystitis in patients treated with radiotherapy for pelvic cancer: a pilot study. (24322388)
2013
5
Hypoxia- and radiation-induced overexpression of Smac by an adenoviral vector and its effects on cell cycle and apoptosis in MDA-MB-231 human breast cancer cells. (24255691)
2013
6
Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-I_B activity in human oral cancer cells. (23340716)
2013
7
Patients with testicular cancer undergoing CT surveillance demonstrate a pitfall of radiation-induced cancer risk estimates: the timing paradox. (23249573)
2013
8
Radiation-induced myositis mimicking chest wall tumor invasion in two patients with lung cancer: a PET/CT study. (22228342)
2012
9
Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration. (22833545)
2012
10
Radiation-induced cancer cell repopulation: a possible mechanism implied by experiments using transplantable mouse-derived sarcoma cell line. (21206131)
2011
11
Radiation-induced cranial nerve palsy: a cross-sectional study of nasopharyngeal cancer patients after definitive radiotherapy. (20605344)
2011
12
Frequent body CT scanning of young adults: indications, outcomes, and risk for radiation-induced cancer. (21723488)
2011
13
Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. (20729006)
2011
14
Association of TGF-I^1 and XPD polymorphisms with severe acute radiation-induced esophageal toxicity in locally advanced lung cancer patients treated with radiotherapy. (20832885)
2010
15
Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. (19900450)
2010
16
Recurrent CT, cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults. (19332852)
2009
17
A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. (19536557)
2009
18
Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells. (19165865)
2009
19
Radiation-induced cancer risk from annual computed tomography for patients with cystic fibrosis. (17717201)
2007
20
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. (17786349)
2007
21
Identification of women with an increased risk of developing radiation-induced breast cancer. (17617928)
2007
22
Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study. (17428320)
2007
23
5-hydroxytryptamine-3 receptor antagonist with or without short-course dexamethasone in the prophylaxis of radiation induced emesis: a placebo-controlled randomized trial of the National Cancer Institute of Canada Clinical Trials Group (SC19). (16849762)
2006
24
Radiation-induced up-regulation of somatostatin receptor expression in small cell lung cancer in vitro. (17045163)
2006
25
Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer? (16979900)
2006
26
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line. (16516153)
2006
27
Dose-response relationship for radiation-induced cancer--decrease or plateau at high dose: in regard to Davis (Int J Radiat Oncol Biol Phys 2004;59:916). (15629639)
2005
28
The risk of radiation-induced cancer in patients with squamous cell carcinoma of the head and neck and its results of treatment. (16249604)
2005
29
Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. (15586221)
2005
30
Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1). (14712319)
2003
31
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. (12509261)
2002
32
Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3. (12170775)
2002
33
The two-stage clonal expansion model as an example of a biologically based model of radiation-induced cancer. (11604092)
2001
34
Establishment of a radiation- and estrogen-induced breast cancer model. (10753214)
2000
35
Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice. (10749125)
2000
36
Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: radiation-induced lung toxicity. (11020572)
2000
37
Tumour response and radiation-induced lung injury in patients with recurrent small cell lung cancer treated with radiotherapy and concomitant interferon-alpha. (10100145)
1999
38
Tamsulosin palliates radiation-induced urethritis in patients with prostate cancer: results of a pilot study. (10524406)
1999
39
Current perspectives on radiation-induced breast cancer. (9440762)
1998
40
bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. (9033638)
1997
41
Radiation-induced brachial plexopathy: neurological follow-up in 161 recurrence-free breast cancer patients. (8387067)
1993
42
Herbert M. Parker Lecture. The risk of radiation induced cancer--whence? Whither? (8230315)
1993
43
Radiation-induced chromatid aberrations in Cockayne syndrome and xeroderma pigmentosum group C fibroblasts in relation to cancer predisposition. (1756475)
1991
44
Radiation-induced brachial plexus neuropathy in breast cancer patients. (2261203)
1990
45
"Radiation-induced" cancer. (2772653)
1989
46
Radiation-induced cancer in rat skin. (2646018)
1989
47
Tests of the linearity assumption in the dose-effect relationship for radiation-induced cancer. (6821536)
1980
48
Carcinomatous versus radiation-induced brachial plexus neuropathy in breast cancer. (207407)
1978
49
Prevention of, and treatment of radiation-induced cancer, including pure atomic and cathode ray lesions. (5220122)
1964
50
THE BIOLOGY OF RADIATION-INDUCED CANCER. (14131924)
1964

Genetic Variations for Radiation Induced Cancer

Expression for genes affiliated with Radiation Induced Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Radiation Induced Cancer

Search GEO for disease gene expression data for Radiation Induced Cancer.

Pathways for genes affiliated with Radiation Induced Cancer

Sources:
4Cell Signaling Technology, 52QIAGEN, 54Reactome, 12EMD Millipore
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Pathways related to Radiation Induced Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1XPC, BRCA1
2
Hide members
9.1XPC, BRCA1
3
Hide members
9.1XPC, BRCA1
4
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.1XPC, BRCA1

Compounds for genes affiliated with Radiation Induced Cancer

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
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Compounds related to Radiation Induced Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligonucleotide459.1XPC, BRCA1
2benzo(a)pyrene459.0XPC, BRCA1
3cisplatin45 50 60 1111.8XPC, BRCA1

GO Terms for genes affiliated with Radiation Induced Cancer

Sources:
16Gene Ontology
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Biological processes related to Radiation Induced Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:0062819.1XPC, BRCA1

Products for genes affiliated with Radiation Induced Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Radiation Induced Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet