MCID: RDT013
MIFTS: 51

Radiation Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Radiation Proctitis

MalaCards integrated aliases for Radiation Proctitis:

Name: Radiation Proctitis 55 69

Characteristics:

Orphanet epidemiological data:

55
radiation proctitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 55 ORPHA70475
UMLS via Orphanet 70 C0400827
ICD10 via Orphanet 33 K62.7
ICD10 32 K62.7
UMLS 69 C0400827

Summaries for Radiation Proctitis

MalaCards based summary : Radiation Proctitis is related to proctitis and superficial siderosis of the central nervous system, and has symptoms including hematochezia, abnormality of connective tissue and abnormality of gastrointestinal vasculature. An important gene associated with Radiation Proctitis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and MAPK signaling pathway. The drugs Sucralfate and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and endothelial, and related phenotypes are Decreased viability with carboplatin and Decreased viability with carboplatin

Wikipedia : 72 Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of... more...

Related Diseases for Radiation Proctitis

Diseases related to Radiation Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 proctitis 30.6 ENTPD1 KDR LTF PECAM1 TNF
2 superficial siderosis of the central nervous system 10.4 LTF TF
3 melancholia 10.4 TF TNF
4 hemangioendothelioma 10.4 KDR PECAM1
5 superficial siderosis 10.4 LTF TF
6 kaposiform hemangioendothelioma 10.4 KDR PECAM1
7 pulmonary vein stenosis 10.4 KDR PECAM1
8 rheumatoid vasculitis 10.3 LTF TNF
9 senile angioma 10.3 KDR TF
10 prostatitis 10.3
11 cavernous hemangioma 10.3 KDR PECAM1
12 laryngitis 10.3 FGF2 TNF
13 critical limb ischemia 10.3 TNF VEGFA
14 diverticulitis 10.2 FGF2 TNF
15 hydrocele 10.2 PECAM1 VEGFA
16 poems syndrome 10.2 TNF VEGFA
17 angiokeratoma circumscriptum 10.2 KDR VEGFA
18 soft tissue sarcoma 10.2 TNF VEGFA
19 haemophilus influenzae 10.2 LTF TF TNF
20 skin hemangioma 10.2 KDR VEGFA
21 lymphangiosarcoma 10.2 TNF VEGFA
22 kuhnt-junius degeneration 10.1 KDR VEGFA
23 acute hemorrhagic leukoencephalitis 10.1 KDR VEGFA
24 chronic myocardial ischemia 10.1 FGF2 VEGFA
25 angiodysplasia 10.1 FGF2 VEGFA
26 coats disease 10.1 KDR VEGFA
27 dysentery 10.1 LTF TF
28 tuberculous meningitis 10.1 TNF VEGFA
29 leukostasis 10.1 KDR VEGFA
30 dry eye syndrome 10.1 FGF2 LTF TNF
31 endotheliitis 10.1
32 prostate cancer 10.1
33 dupuytren contracture 10.0 FGF2 VEGFA
34 eales disease 10.0 TF TNF VEGFA
35 rosacea 10.0 TNF VEGFA
36 capillary hemangioma 10.0 KDR PECAM1 VEGFA
37 epithelioid hemangioendothelioma 10.0 KDR PECAM1 VEGFA
38 vitreous disease 10.0 FGF2 VEGFA
39 angiosarcoma 10.0 KDR PECAM1 VEGFA
40 lymphangioma 10.0 KDR VEGFA
41 cervicitis 10.0
42 juvenile nasopharyngeal angiofibroma 10.0 FGF2 PECAM1 VEGFA
43 gastrointestinal system disease 9.9 EDNRB LTF TNF
44 kaposi sarcoma 9.9 FGF2 TNF VEGFA
45 suppressor of tumorigenicity 3 9.9
46 gastric antral vascular ectasia 9.9
47 hemorrhoid 9.9
48 vascular cancer 9.9 FGF2 KDR VEGFA
49 corneal neovascularization 9.9 FGF2 KDR VEGFA
50 breast carcinoma in situ 9.9 FGF2 KDR VEGFA

Graphical network of the top 20 diseases related to Radiation Proctitis:



Diseases related to Radiation Proctitis

Symptoms & Phenotypes for Radiation Proctitis

Human phenotypes related to Radiation Proctitis:

55 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematochezia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002573
2 abnormality of connective tissue 55 31 hallmark (90%) Very frequent (99-80%) HP:0003549
3 abnormality of gastrointestinal vasculature 55 31 hallmark (90%) Very frequent (99-80%) HP:0004296
4 rectal abscess 55 31 hallmark (90%) Very frequent (99-80%) HP:0005224
5 rectal fistula 55 31 hallmark (90%) Very frequent (99-80%) HP:0100590
6 intestinal obstruction 55 31 occasional (7.5%) Occasional (29-5%) HP:0005214
7 arteritis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012089
8 tenesmus 55 31 occasional (7.5%) Occasional (29-5%) HP:0012702
9 sepsis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100806
10 abnormality of the rectum 55 Very frequent (99-80%)
11 abnormality of the vasculature 55 Very frequent (99-80%)
12 abnormal vascular morphology 55 Very frequent (99-80%)
13 diarrhea 55 Occasional (29-5%)

GenomeRNAi Phenotypes related to Radiation Proctitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with carboplatin GR00207-A-11 8.92 ENTPD1
2 Decreased viability with carboplatin GR00207-A-7 8.92 EDNRA ENTPD1
3 Decreased viability with carboplatin GR00207-A-9 8.92 EDNRA

MGI Mouse Phenotypes related to Radiation Proctitis:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 LTF PECAM1 TF TNF VEGFA AOC1
2 homeostasis/metabolism MP:0005376 10.17 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
3 cardiovascular system MP:0005385 10.16 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
4 behavior/neurological MP:0005386 10.13 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
5 cellular MP:0005384 10.1 EDNRA EDNRB FGF2 KDR LTF PECAM1
6 immune system MP:0005387 10.01 EDNRA EDNRB ENTPD1 KDR LTF PECAM1
7 muscle MP:0005369 9.92 EDNRA EDNRB ENTPD1 FGF2 KDR PECAM1
8 craniofacial MP:0005382 9.88 EDNRA EDNRB KDR TNF VEGFA
9 liver/biliary system MP:0005370 9.85 LTF PECAM1 TNF VEGFA ENTPD1 KDR
10 respiratory system MP:0005388 9.7 EDNRA EDNRB ENTPD1 KDR PECAM1 TNF
11 neoplasm MP:0002006 9.65 FGF2 LTF TNF VEGFA EDNRB
12 skeleton MP:0005390 9.56 EDNRA EDNRB ENTPD1 FGF2 KDR PECAM1
13 vision/eye MP:0005391 9.23 FGF2 KDR TNF VEGFA AOC1 EDNRA

Drugs & Therapeutics for Radiation Proctitis

Drugs for Radiation Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sucralfate Approved Phase 4 54182-58-0 0
2 Gastrointestinal Agents Phase 4
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5
Inulin Approved, Investigational, Nutraceutical Phase 3 9005-80-5 24763
6 Acidophilus Nutraceutical Phase 2, Phase 3
7
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
10
Bisacodyl Approved Phase 2 603-50-9
11
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741 24759
12
Budesonide Approved Phase 2 51333-22-3 5281004 63006
13 Orange Approved, Nutraceutical Phase 2
14 glucocorticoids Phase 2
15 Respiratory System Agents Phase 2
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Peripheral Nervous System Agents Phase 2
20 Anti-Asthmatic Agents Phase 2
21 Anti-Inflammatory Agents Phase 2
22 Autonomic Agents Phase 2
23 Bronchodilator Agents Phase 2
24 Cola Nutraceutical Phase 2
25 Anesthetics

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
2 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
3 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
4 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
5 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
6 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
7 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
8 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
9 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933
10 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
11 Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study Not yet recruiting NCT03397901

Search NIH Clinical Center for Radiation Proctitis

Genetic Tests for Radiation Proctitis

Anatomical Context for Radiation Proctitis

MalaCards organs/tissues related to Radiation Proctitis:

38
Prostate, Colon, Endothelial, Cervix

Publications for Radiation Proctitis

Articles related to Radiation Proctitis:

(show top 50) (show all 179)
# Title Authors Year
1
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
2
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
3
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
4
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
5
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
6
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
7
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
8
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
9
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
10
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
11
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
12
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
13
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
14
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
15
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
16
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
17
Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. ( 26256683 )
2015
18
Chronic radiation proctitis: tricks to prevent and treat. ( 26198994 )
2015
19
Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? ( 26547382 )
2015
20
Minimally invasive treatment of radiation proctitis and piles - a video vignette. ( 26382829 )
2015
21
Formalin therapy for hemorrhagic radiation proctitis. ( 26398382 )
2015
22
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. ( 26185013 )
2015
23
Formalin irrigation for hemorrhagic chronic radiation proctitis. ( 25834325 )
2015
24
The Efficacy of Probiotic (Lactobacillus rhamnosus GG) and 5-ASA (Aminosalicylic Acid) in the Treatment of Experimental Radiation Proctitis in Rats. ( 26730065 )
2015
25
Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice. ( 25577272 )
2015
26
Is argon plasma coagulation an effective and safe treatment option for patients with chronic radiation proctitis after high doses of radiotherapy? ( 25007015 )
2014
27
Daily sodium butyrate enema for the prevention of radiation proctitis in prostate cancer patients undergoing radical radiation therapy: results of a multicenter randomized placebo-controlled dose-finding phase 2 study. ( 24803033 )
2014
28
Radiofrequency ablation for the treatment of radiation proctitis. ( 25290097 )
2014
29
Cryotherapy for treatment of radiation proctitis. ( 24140130 )
2014
30
Argon gas in the management of radiation proctitis--effective and safe for everyone? ( 25007013 )
2014
31
Radiofrequency ablation for chronic radiation proctitis: our initial experience with four cases. ( 24915942 )
2014
32
Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial. ( 25304789 )
2014
33
A cure for post-radiation proctitis? ( 23736909 )
2013
34
Letter to the editor concerning: Hawkins M, Billingham R, Bastawrous A. Hemorrhoid management in patients with radiation proctitis. Int J Colorectal Dis. 2012 Jun 20. [Epub ahead of print]. ( 23011547 )
2013
35
Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. ( 23102757 )
2013
36
Management of radiation proctitis. ( 24280407 )
2013
37
Clinical and proctoscopic evaluation of topical formalin application in the treatment of chronic radiation proctitis. ( 23820684 )
2013
38
Sucralfate paste enema; a new method of topical treatment for haemorrhagic radiation proctitis. ( 24299100 )
2013
39
Efficacy of cryospray ablation for the treatment of chronic radiation proctitis in a pilot study. ( 23362977 )
2013
40
Management of Radiation Proctitis. ( 23241500 )
2013
41
Endoscopic treatments for chronic radiation proctitis. ( 23858374 )
2013
42
Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial. ( 23006660 )
2013
43
Effects of ozonated olive oil on acute radiation proctitis in rats. ( 25207143 )
2013
44
Successful management using endoclips of rectal perforation during retroflexion in a patient with radiation proctitis. ( 23526525 )
2013
45
Radiofrequency ablation for the treatment of radiation proctitis: a case report and review of literature. ( 23320051 )
2013
46
Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate. ( 23516076 )
2013
47
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. ( 24138319 )
2013
48
Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis. ( 23737650 )
2013
49
Rectal band ligation for treatment of extensive chronic hemorrhagic radiation proctitis. ( 23012030 )
2012
50
A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors. ( 22081051 )
2012

Variations for Radiation Proctitis

Expression for Radiation Proctitis

Search GEO for disease gene expression data for Radiation Proctitis.

Pathways for Radiation Proctitis

GO Terms for Radiation Proctitis

Cellular components related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AOC1 FGF2 KDR LTF TF TNF
2 cell surface GO:0009986 9.56 LTF TF TNF VEGFA
3 extracellular space GO:0005615 9.5 AOC1 FGF2 LTF PECAM1 TF TNF
4 membrane raft GO:0045121 8.92 EDNRB KDR PECAM1 TNF

Biological processes related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.88 EDNRB KDR LTF VEGFA
2 positive regulation of cell proliferation GO:0008284 9.87 EDNRB FGF2 KDR VEGFA
3 negative regulation of gene expression GO:0010629 9.77 KDR TNF VEGFA
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 FGF2 KDR TNF
5 positive regulation of angiogenesis GO:0045766 9.69 FGF2 KDR VEGFA
6 platelet degranulation GO:0002576 9.67 PECAM1 TF VEGFA
7 extracellular matrix organization GO:0030198 9.62 FGF2 KDR PECAM1 TNF
8 positive regulation of endothelial cell proliferation GO:0001938 9.61 FGF2 KDR VEGFA
9 branching involved in blood vessel morphogenesis GO:0001569 9.58 EDNRA VEGFA
10 positive regulation of MAP kinase activity GO:0043406 9.58 FGF2 TNF VEGFA
11 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.56 KDR VEGFA
12 positive regulation of protein phosphorylation GO:0001934 9.56 EDNRB KDR TNF VEGFA
13 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
14 positive regulation of protein complex assembly GO:0031334 9.54 TNF VEGFA
15 vasoconstriction GO:0042310 9.52 EDNRA EDNRB
16 positive regulation of positive chemotaxis GO:0050927 9.48 KDR VEGFA
17 enteric nervous system development GO:0048484 9.46 EDNRA EDNRB
18 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.37 KDR VEGFA
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.33 FGF2 KDR VEGFA
20 endothelin receptor signaling pathway GO:0086100 8.96 EDNRA EDNRB
21 cell migration involved in sprouting angiogenesis GO:0002042 8.8 FGF2 KDR VEGFA

Molecular functions related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 FGF2 TNF VEGFA
2 heparin binding GO:0008201 9.26 AOC1 FGF2 LTF VEGFA
3 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
4 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Radiation Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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