MCID: RDT013
MIFTS: 46

Radiation Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Radiation Proctitis

MalaCards integrated aliases for Radiation Proctitis:

Name: Radiation Proctitis 56 69

Characteristics:

Orphanet epidemiological data:

56
radiation proctitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA70475
UMLS via Orphanet 70 C0400827
ICD10 via Orphanet 34 K62.7
ICD10 33 K62.7

Summaries for Radiation Proctitis

MalaCards based summary : Radiation Proctitis is related to proctitis and euthyroid sick syndrome, and has symptoms including hematochezia, abnormality of connective tissue and abnormality of gastrointestinal vasculature. An important gene associated with Radiation Proctitis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and Proteoglycans in cancer. The drugs Sucralfate and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and endothelial, and related phenotypes are Decreased viability with carboplatin and homeostasis/metabolism

Wikipedia : 72 Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of... more...

Related Diseases for Radiation Proctitis

Diseases related to Radiation Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 proctitis 10.8
2 euthyroid sick syndrome 10.6 TF TNF
3 superior vena cava syndrome 10.6 LTF TF
4 hemi 3 syndrome 10.6 KDR PECAM1
5 kasznica carlson coppedge syndrome 10.6 KDR PECAM1
6 pituicytoma 10.6 LTF TF
7 punctate palmoplantar keratoderma type 2 10.6 KDR PECAM1
8 riboflavin transporter deficiency 10.5 LTF TNF
9 alcohol-induced mental disorder 10.5 KDR TF
10 scrotal carcinoma 10.5 FGF2 TNF
11 myoepithelial carcinoma 10.5 KDR PECAM1
12 cutaneous leishmaniasis 10.5 TNF VEGFA
13 petrous apex meningioma 10.4 FGF2 TNF
14 waterhouse-friderichsen syndrome 10.4 PECAM1 VEGFA
15 bipolar i disorder 10.4 TNF VEGFA
16 kidney pelvis papillary carcinoma 10.4 KDR VEGFA
17 sparse hair ptosis mental retardation 10.3 TNF VEGFA
18 senile reticular retinal degeneration 10.3 LTF TNF
19 renal adenoma 10.3 TNF VEGFA
20 extragonadal germ cell cancer 10.3 KDR VEGFA
21 iliac vein thrombophlebitis 10.3 KDR VEGFA
22 halal setton wang syndrome 10.3 LTF TF TNF
23 tumefactive multiple sclerosis 10.3 TNF VEGFA
24 lens disease 10.3 KDR VEGFA
25 colorectal adenoma 10.3 FGF2 VEGFA
26 tooth erosion 10.3 FGF2 VEGFA
27 factitious disorder 10.2 KDR VEGFA
28 prostatitis 10.2
29 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 10.2 KDR VEGFA
30 purulent endophthalmitis 10.2 FGF2 VEGFA
31 phlegmonous dacryocystitis 10.2 KDR VEGFA
32 thymus lymphoma 10.2 FGF2 LTF TNF
33 ohdo syndrome, maat-kievit-brunner type 10.1 FGF2 VEGFA
34 early-onset zonular cataract 10.1 TF TNF VEGFA
35 pityriasis rosea 10.1 TNF VEGFA
36 prostate cancer 10.1
37 vesiculobullous skin disease 10.1 KDR PECAM1 VEGFA
38 coloboma of superior eyelid 10.1 KDR PECAM1 VEGFA
39 tumor of exocrine pancreas 10.1 FGF2 VEGFA
40 chikungunya 10.1 KDR PECAM1 VEGFA
41 benign familial neonatal epilepsy 10.1 KDR VEGFA
42 tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria 10.1 FGF2 PECAM1 VEGFA
43 anaerobic meningitis 10.0 TNF VEGFA
44 tuberculum sellae meningioma 10.0 EDNRB LTF TNF
45 intracranial hemorrhage in brain cerebrovascular malformations 10.0 FGF2 TNF VEGFA
46 autoimmune hepatitis 9.9 PECAM1 TNF VEGFA
47 mitral valve stenosis 9.9 FGF2 KDR VEGFA
48 subdural empyema 9.9 FGF2 KDR VEGFA
49 citrullinemia, adult-onset type ii 9.9 FGF2 KDR VEGFA
50 cervicitis 9.9

Graphical network of the top 20 diseases related to Radiation Proctitis:



Diseases related to Radiation Proctitis

Symptoms & Phenotypes for Radiation Proctitis

Human phenotypes related to Radiation Proctitis:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 hematochezia 32 hallmark (90%) HP:0002573
2 abnormality of connective tissue 32 hallmark (90%) HP:0003549
3 abnormality of gastrointestinal vasculature 32 hallmark (90%) HP:0004296
4 intestinal obstruction 32 occasional (7.5%) HP:0005214
5 rectal abscess 32 hallmark (90%) HP:0005224
6 arteritis 32 occasional (7.5%) HP:0012089
7 tenesmus 32 occasional (7.5%) HP:0012702
8 abnormal vascular morphology 32 hallmark (90%) HP:0025015
9 rectal fistula 32 hallmark (90%) HP:0100590
10 sepsis 32 occasional (7.5%) HP:0100806

GenomeRNAi Phenotypes related to Radiation Proctitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with carboplatin GR00207-A-11 8.92 ENTPD1
2 Decreased viability with carboplatin GR00207-A-7 8.92 EDNRA ENTPD1
3 Decreased viability with carboplatin GR00207-A-9 8.92 EDNRA

MGI Mouse Phenotypes related to Radiation Proctitis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 TF TNF LTF VEGFA PECAM1 KDR
2 hematopoietic system MP:0005397 10.16 TF TNF VEGFA PECAM1 KDR ENTPD1
3 cardiovascular system MP:0005385 10.15 PECAM1 TNF VEGFA EDNRB KDR ENTPD1
4 behavior/neurological MP:0005386 10.11 VEGFA TNF EDNRB KDR AOC1 ENTPD1
5 cellular MP:0005384 10.08 VEGFA PECAM1 TNF LTF EDNRB KDR
6 immune system MP:0005387 10.01 VEGFA PECAM1 TNF LTF EDNRB KDR
7 muscle MP:0005369 9.92 TNF VEGFA PECAM1 EDNRB KDR ENTPD1
8 liver/biliary system MP:0005370 9.85 PECAM1 TNF LTF VEGFA KDR ENTPD1
9 respiratory system MP:0005388 9.7 PECAM1 TNF VEGFA EDNRB KDR ENTPD1
10 neoplasm MP:0002006 9.65 VEGFA TNF LTF EDNRB FGF2
11 skeleton MP:0005390 9.56 PECAM1 TNF VEGFA EDNRB KDR ENTPD1
12 vision/eye MP:0005391 9.23 TNF VEGFA EDNRB KDR ENTPD1 AOC1

Drugs & Therapeutics for Radiation Proctitis

Drugs for Radiation Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sucralfate Approved Phase 4 54182-58-0
2 Gastrointestinal Agents Phase 4
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5
Inulin Approved, Nutraceutical Phase 3 9005-80-5 24763
6 Acidophilus Nutraceutical Phase 2, Phase 3
7
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
10
Bisacodyl Approved Phase 2 603-50-9
11
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741 24759
12
Budesonide Approved Phase 2 51333-22-3 63006 5281004
13 Orange Approved, Nutraceutical Phase 2
14
Curcumin Investigational Phase 2 458-37-7 969516
15 Analgesics Phase 2
16 Analgesics, Non-Narcotic Phase 2
17 Peripheral Nervous System Agents Phase 2
18 Anti-Inflammatory Agents Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2
20 Antirheumatic Agents Phase 2
21 glucocorticoids Phase 2
22 Respiratory System Agents Phase 2
23 Hormone Antagonists Phase 2
24 Hormones Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
26 Anti-Asthmatic Agents Phase 2
27 Autonomic Agents Phase 2
28 Bronchodilator Agents Phase 2
29 Cola Nutraceutical Phase 2
30
Epinephrine Approved, Vet_approved 51-43-4 5816
31 Racepinephrine Approved
32 Epinephryl borate

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
2 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
3 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
4 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
5 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
6 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
7 Ion Prostate Irradiation Completed NCT01641185 Phase 2
8 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
9 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
10 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
11 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
12 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
13 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933
14 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
15 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
16 Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Recruiting NCT02836379

Search NIH Clinical Center for Radiation Proctitis

Genetic Tests for Radiation Proctitis

Anatomical Context for Radiation Proctitis

MalaCards organs/tissues related to Radiation Proctitis:

39
Prostate, Colon, Endothelial, Cervix

Publications for Radiation Proctitis

Articles related to Radiation Proctitis:

(show top 50) (show all 177)
id Title Authors Year
1
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
2
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
3
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
4
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
5
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
6
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
7
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
8
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
9
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
10
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
11
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
12
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
13
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
14
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
15
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. ( 26185013 )
2015
16
Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice. ( 25577272 )
2015
17
Chronic radiation proctitis: tricks to prevent and treat. ( 26198994 )
2015
18
Formalin irrigation for hemorrhagic chronic radiation proctitis. ( 25834325 )
2015
19
Formalin therapy for hemorrhagic radiation proctitis. ( 26398382 )
2015
20
Minimally invasive treatment of radiation proctitis and piles - a video vignette. ( 26382829 )
2015
21
The Efficacy of Probiotic (Lactobacillus rhamnosus GG) and 5-ASA (Aminosalicylic Acid) in the Treatment of Experimental Radiation Proctitis in Rats. ( 26730065 )
2015
22
Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. ( 26256683 )
2015
23
Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? ( 26547382 )
2015
24
Cryotherapy for treatment of radiation proctitis. ( 24140130 )
2014
25
Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial. ( 25304789 )
2014
26
Radiofrequency ablation for the treatment of radiation proctitis. ( 25290097 )
2014
27
Radiofrequency ablation for chronic radiation proctitis: our initial experience with four cases. ( 24915942 )
2014
28
Daily sodium butyrate enema for the prevention of radiation proctitis in prostate cancer patients undergoing radical radiation therapy: results of a multicenter randomized placebo-controlled dose-finding phase 2 study. ( 24803033 )
2014
29
Argon gas in the management of radiation proctitis--effective and safe for everyone? ( 25007013 )
2014
30
Is argon plasma coagulation an effective and safe treatment option for patients with chronic radiation proctitis after high doses of radiotherapy? ( 25007015 )
2014
31
Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial. ( 23006660 )
2013
32
Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. ( 23102757 )
2013
33
Successful management using endoclips of rectal perforation during retroflexion in a patient with radiation proctitis. ( 23526525 )
2013
34
Clinical and proctoscopic evaluation of topical formalin application in the treatment of chronic radiation proctitis. ( 23820684 )
2013
35
Management of radiation proctitis. ( 24280407 )
2013
36
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. ( 24138319 )
2013
37
A cure for post-radiation proctitis? ( 23736909 )
2013
38
Sucralfate paste enema; a new method of topical treatment for haemorrhagic radiation proctitis. ( 24299100 )
2013
39
Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis. ( 23737650 )
2013
40
Effects of ozonated olive oil on acute radiation proctitis in rats. ( 25207143 )
2013
41
Radiofrequency ablation for the treatment of radiation proctitis: a case report and review of literature. ( 23320051 )
2013
42
Efficacy of cryospray ablation for the treatment of chronic radiation proctitis in a pilot study. ( 23362977 )
2013
43
Letter to the editor concerning: Hawkins M, Billingham R, Bastawrous A. Hemorrhoid management in patients with radiation proctitis. Int J Colorectal Dis. 2012 Jun 20. [Epub ahead of print]. ( 23011547 )
2013
44
Endoscopic treatments for chronic radiation proctitis. ( 23858374 )
2013
45
Management of Radiation Proctitis. ( 23241500 )
2013
46
Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate. ( 23516076 )
2013
47
Long-term sequential changes of radiation proctitis and angiopathy in rats. ( 22510594 )
2012
48
Hemorrhoid management in patients with radiation proctitis. ( 22714783 )
2012
49
Possible risk factors associated with radiation proctitis or radiation cystitis in patients with cervical carcinoma after radiotherapy. ( 23464440 )
2012
50
Rectal band ligation for treatment of extensive chronic hemorrhagic radiation proctitis. ( 23012030 )
2012

Variations for Radiation Proctitis

Expression for Radiation Proctitis

Search GEO for disease gene expression data for Radiation Proctitis.

Pathways for Radiation Proctitis

GO Terms for Radiation Proctitis

Cellular components related to Radiation Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AOC1 FGF2 KDR LTF TF TNF
2 cell surface GO:0009986 9.56 LTF TF TNF VEGFA
3 extracellular space GO:0005615 9.5 AOC1 FGF2 LTF PECAM1 TF TNF
4 membrane raft GO:0045121 8.92 EDNRB KDR PECAM1 TNF

Biological processes related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 EDNRB FGF2 KDR VEGFA
2 negative regulation of apoptotic process GO:0043066 9.87 EDNRB KDR LTF VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 FGF2 KDR TNF
4 platelet degranulation GO:0002576 9.67 PECAM1 TF VEGFA
5 positive regulation of angiogenesis GO:0045766 9.65 FGF2 KDR VEGFA
6 branching involved in blood vessel morphogenesis GO:0001569 9.58 EDNRA VEGFA
7 positive regulation of endothelial cell proliferation GO:0001938 9.58 FGF2 KDR VEGFA
8 positive regulation of focal adhesion assembly GO:0051894 9.56 KDR VEGFA
9 extracellular matrix organization GO:0030198 9.56 FGF2 KDR PECAM1 TNF
10 positive regulation of protein complex assembly GO:0031334 9.55 TNF VEGFA
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.54 FGF2 VEGFA
12 positive regulation of MAP kinase activity GO:0043406 9.54 FGF2 TNF VEGFA
13 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.52 KDR VEGFA
14 vasoconstriction GO:0042310 9.51 EDNRA EDNRB
15 positive regulation of positive chemotaxis GO:0050927 9.46 KDR VEGFA
16 positive regulation of protein phosphorylation GO:0001934 9.46 EDNRB KDR TNF VEGFA
17 enteric nervous system development GO:0048484 9.43 EDNRA EDNRB
18 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.32 KDR VEGFA
19 protein kinase B signaling GO:0043491 9.3 TNF
20 endothelin receptor signaling pathway GO:0086100 8.96 EDNRA EDNRB
21 cell migration involved in sprouting angiogenesis GO:0002042 8.8 FGF2 KDR VEGFA

Molecular functions related to Radiation Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 FGF2 TNF VEGFA
2 heparin binding GO:0008201 9.26 AOC1 FGF2 LTF VEGFA
3 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
4 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Radiation Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....