RE
MCID: RSM001
MIFTS: 42

Rasmussen Encephalitis (RE) malady

Rare diseases, Neuronal diseases categories
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Summaries for Rasmussen Encephalitis

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NIH Rare Diseases:42 Rasmussen encephalitis is a chronic inflammatory neurological disease that usually affects only one hemisphere of the brain. it most often occurs in children under the age of 10, although adolescents and adults may also be affected. rasmussen encephalitis is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. while the cause of rasmussen encephalitis is unknown, there is evidence that in many patients it is an autoimmune disorder. immune therapy and surgery may be used for treatment. last updated: 3/22/2012

MalaCards based summary: Rasmussen Encephalitis, also known as rasmussen's encephalitis, is related to epilepsy syndrome and encephalitis. An important gene associated with Rasmussen Encephalitis is GRIA3 (glutamate receptor, ionotropic, AMPA 3), and among its related pathways are Glutamic acid signaling and Nicotine addiction. The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and 3-Sulfinoalanine have been mentioned in the context of this disorder. Affiliated tissues include brain and t cells, and related mouse phenotypes are respiratory system and behavior/neurological.

NINDS:43 Rasmussen?s encephalitis is a rare, chronic inflammatory neurological disease that usually affects only one hemisphere of the brain.

Aliases & Classifications for Rasmussen Encephalitis

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS, 43NINDS
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Rasmussen Encephalitis, Aliases & Descriptions:

Name: Rasmussen Encephalitis 42 44 62
Rasmussen's Encephalitis 43
 
Re 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Rasmussen Encephalitis

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Diseases in the Rasmussen Encephalitis family:

Rasmussen Subacute Encephalitis

Diseases related to Rasmussen Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome30.9SCN2B
2encephalitis11.1
3limbic encephalitis10.5GAD1
4scleroderma10.3
5linear scleroderma10.3
6alopecia areata10.2GZMB, IFNG
7acute graft versus host disease10.2GZMB, IFNG
8type 1 diabetes mellitus10.2GAD1, IFNG
9aplastic anemia10.2GZMB, IFNG
10hepatitis10.2GZMB, GSR
11cutaneous t cell lymphoma10.2GZMB, IFNG
12sjogren's syndrome10.2GAD1, GZMB
13graft versus host disease10.2GZMB, IFNG
14plasmodium falciparum malaria10.2GSR, IFNG
15schistosomiasis10.2GSR, IFNG
16autoimmune thyroiditis10.2GAD1, IFNG
17lymphopenia10.2IFNG, GSR
18psychotic disorder10.2CHRNA7, GAD1
19vitiligo10.2
20status epilepticus10.2
21gliomatosis cerebri10.2
22tuberous sclerosis10.2
23neuronitis10.2
24cerebritis10.2
25acute intermittent porphyria10.2
26meningitis10.2
27porphyria10.2
28vasculitis10.2
29tuberous sclerosis complex10.2
30febrile infection-related epilepsy syndrome10.2
31sturge-weber syndrome10.2
32weber syndrome10.2
33myoclonus10.2
34autistic disorder10.2GAD1, CHRNA7
35dermatitis10.1IFNG, GZMB
36bipolar disorder10.1CHRNA7, GRIA3, GAD1
37insulinoma10.1GAD1, GSR
38tetanus10.1GAD1, IFNG
39hepatitis b10.1IFNG, GSR, GZMB
40hepatitis c10.1GSR, IFNG
41parkinson's disease10.1GAD1, GSR, CHRNA7
42multiple sclerosis10.0IFNG, GSR, GAD1
43hypersensitivity reaction type ii disease10.0GAD1, GZMB, IFNG
44viral infectious disease10.0IFNG, GZMB, GAD1
45sarcoidosis10.0GZMB, IFNG
46asthma9.9GZMB, GSR, IFNG
47schizophrenia9.9GAD1, GRIA3, GSR, CHRNA7
48ischemia9.9GAD1, GSR, ADK
49tuberculosis9.7GZMB, GSR, IFNG, ADK

Graphical network of the top 20 diseases related to Rasmussen Encephalitis:



Diseases related to rasmussen encephalitis

Symptoms for Rasmussen Encephalitis

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Drugs & Therapeutics for Rasmussen Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Rasmussen Encephalitis

Search NIH Clinical Center for Rasmussen Encephalitis

Genetic Tests for Rasmussen Encephalitis

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Anatomical Context for Rasmussen Encephalitis

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MalaCards organs/tissues related to Rasmussen Encephalitis:

32
Brain, T cells

Animal Models for Rasmussen Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Rasmussen Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2GAD1, IFNG, CHRNA7, ADK
2MP:00053867.6SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
3MP:00036317.4SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
4MP:00107686.9GAD1, SCN1A, ADK, CHRNA7, IFNG, GRIA3

Publications for Rasmussen Encephalitis

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Articles related to Rasmussen Encephalitis:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). (24639375)
2014
2
Voltage-gated potassium channels autoantibodies in a child with rasmussen encephalitis. (25062271)
2014
3
Surgical treatment of patients with Rasmussen encephalitis. (24503650)
2014
4
Hemispherotomy in Rasmussen encephalitis: long-term outcome in an Italian series of 16 patients. (24815913)
2014
5
Exceptional verbal intelligence after hemispherotomy in a child with Rasmussen encephalitis. (24471481)
2014
6
Editorial comment: The janus of Rasmussen encephalitis: never a friendly face. (25149948)
2014
7
Transition into adulthood: tuberous sclerosis complex, Sturge-Weber syndrome, and Rasmussen encephalitis. (25209083)
2014
8
Rasmussen encephalitis. (23622199)
2013
9
Rasmussen encephalitis treated with natalizumab. (23794679)
2013
10
Altered transporter-mediated neocortical GABA release in Rasmussen encephalitis. (23360283)
2013
11
Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia. (23531608)
2013
12
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. (23980696)
2013
13
Differential expression of interferon-I^ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response. (23639073)
2013
14
Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. (23216622)
2013
15
Hemiatrophy and seizures: a case of adult-onset Rasmussen encephalitis. (23315464)
2013
16
Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis. (22309137)
2012
17
Early add-on immunoglobulin administration in Rasmussen encephalitis: the hypothesis of neuroimmunomodulation. (21885203)
2011
18
Bilateral Rasmussen encephalitis. (21216675)
2011
19
Perfusion SPECT findings in a suspected case of Rasmussen encephalitis. (19021826)
2009
20
Diffusion tensor imaging and tractography of Rasmussen encephalitis. (19390848)
2009
21
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (21686702)
2009
22
Dissociation of epileptic and inflammatory activity in Rasmussen Encephalitis. (19121924)
2009
23
CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. (19179379)
2009
24
Adult onset chronic unihemispheric vasculitis resembling Rasmussen encephalitis. (19741437)
2009
25
Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma. (19615863)
2009
26
MRI appearance of Rasmussen encephalitis. (19294372)
2009
27
Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. (18440783)
2008
28
Rasmussen encephalitis associated with SCN 1 A mutation. (18031552)
2008
29
Acute intermittent porphyria, Rasmussen encephalitis, or both? (17608316)
2007
30
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
31
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (17229752)
2007
32
Parry Romberg syndrome and linear scleroderma en coup de sabre mimicking Rasmussen encephalitis. (18071151)
2007
33
Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizures. (17388985)
2007
34
Parry Romberg syndrome and linear scleroderma in coup de sabre mimicking Rasmussen encephalitis. (17438222)
2007
35
Ictal hemodynamic changes in late-onset rasmussen encephalitis. (16437569)
2006
36
Putaminal involvement in Rasmussen encephalitis. (16710657)
2006
37
Neuropathological spectrum of Rasmussen encephalitis. (16010051)
2005
38
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. (15689357)
2005
39
An open study of tacrolimus therapy in Rasmussen encephalitis. (15184626)
2004
40
Rasmussen encephalitis. (15096412)
2004
41
Rasmussen encephalitis with active inflammation and delayed seizures onset. (15037707)
2004
42
Late language transfer in patients with Rasmussen encephalitis. (12790905)
2003
43
Rasmussen encephalitis associated with Parry-Romberg syndrome. (12913207)
2003
44
MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. (12558582)
2003
45
Bilateral Rasmussen encephalitis: postmortem documentation in a five-year-old. (12581240)
2003
46
Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. (12090428)
2002
47
Ultrastructural study of Rasmussen encephalitis. (12396238)
2002
48
Magnetic resonance and positron emission tomography changes during the clinical progression of Rasmussen encephalitis. (10800268)
2000
49
Evidence for glutamate receptor autoimmunity in the pathogenesis of Rasmussen encephalitis. (10514842)
1999
50
Rasmussen encephalitis in childhood. (10447611)
1999

Variations for Rasmussen Encephalitis

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Expression for genes affiliated with Rasmussen Encephalitis

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Expression patterns in normal tissues for genes affiliated with Rasmussen Encephalitis

Search GEO for disease gene expression data for Rasmussen Encephalitis.

Pathways for genes affiliated with Rasmussen Encephalitis

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Pathways related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8GAD1, GRIA3
29.6CHRNA7, GRIA3
39.6GRIA3, CHRNA7
4
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.6GZMB, IFNG
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.6GZMB, IFNG
6
Show member pathways
9.6IFNG, GZMB
7
Show member pathways
9.6GZMB, IFNG
8
Show member pathways
thioredoxin pathway37
9.5GSR, IFNG
99.4SCN2B, SCN1A
109.4SCN2B, SCN1A
11
Show member pathways
9.3GAD1, GRIA3, CHRNA7
12
Show member pathways
purine deoxyribonucleosides degradation37
purine nucleotides degradation37
adenine and adenosine salvage II37
adenine and adenosine salvage III37
oxidized GTP and dGTP detoxification37
urate biosynthesis/inosine 5-phosphate degradation37
adenine and adenosine salvage I37
purine ribonucleosides degradation to ribose-1-phosphate37
inosine-5-phosphate biosynthesis37
guanosine nucleotides degradation37
guanine and guanosine salvage37
adenosine nucleotides degradation37
5-aminoimidazole ribonucleotide biosynthesis37
9.2GSR, ADK
13
Show member pathways
9.2IFNG, GZMB, GAD1
14
Show member pathways
9.1GRIA3, SCN2B, SCN1A
15
Show member pathways
8.6GAD1, GRIA3, CHRNA7, SCN1A

Compounds for genes affiliated with Rasmussen Encephalitis

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Compounds related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4410.1GSR, GRIA3
23-Sulfinoalanine24 1111.1GAD1, GSR
3chromium4410.1GZMB, GSR
4thiamine44 2 24 1113.0GAD1, GSR
5alpha-galactosylceramide4410.0IFNG, GZMB
6pentobarbital44 1111.0GRIA3, CHRNA7
7vitamin b64410.0GAD1, GSR
8valproate449.9GSR, GAD1
9bicuculline44 2810.9CHRNA7, GAD1
10d penicillamine449.9GSR, IFNG
11concanamycin a44 6110.9GZMB, IFNG
12ebselen449.9GSR, IFNG
13auranofin28 44 61 1112.9IFNG, GSR
14gsno449.8IFNG, GSR
15ivig449.8GZMB, IFNG
16mptp449.8GAD1, CHRNA7
17kynurenine449.8CHRNA7, IFNG
18qx 314 chloride619.8SCN1A, SCN2B
19tetrodotoxin citrate619.8SCN1A, SCN2B
20l-glutamic acid28 24 1111.8GSR, GRIA3, GAD1
21phrixotoxin 3619.8SCN1A, SCN2B
22veratridine44 61 2811.8SCN2B, SCN1A
23zonisamide44 50 1111.7SCN1A, SCN2B
24menadione44 24 1111.7GSR, IFNG
25prednisolone44 28 1111.6IFNG, GZMB, GAD1
26melphalan44 50 1111.6GSR, IFNG
27neopterin449.6IFNG, GZMB
28carbamazepine44 50 1111.6GSR, SCN1A
29clozapine44 28 50 1112.6GAD1, CHRNA7
30tetrodotoxin44 61 2811.5SCN1A, SCN2B, GAD1
31carboplatin44 50 1111.4GSR, IFNG
32ribavirin44 50 1111.3ADK, IFNG
33gaba449.3CHRNA7, GSR, GRIA3, GAD1
34aspartate449.2CHRNA7, GSR, GZMB, GAD1
35pge2449.2GSR, IFNG, CHRNA7
36tacrolimus44 50 1111.2ADK, IFNG, GZMB
37alanine449.2CHRNA7, GSR, GZMB, GAD1
38kainate44 2810.0ADK, GSR, GRIA3, GAD1
39glucose 6-phosphate44 249.9GSR, ADK
40glutamate448.9GAD1, GZMB, GRIA3, GSR, CHRNA7
41potassium44 24 1110.9GAD1, ADK, SCN1A
42cyclosporin a44 28 6110.8GAD1, GZMB, IFNG, ADK
43nmda44 289.5GAD1, GRIA3, GSR, CHRNA7, ADK
44arginine448.4ADK, IFNG, GSR, GZMB, GAD1
45oxygen44 249.4GAD1, GZMB, GSR, CHRNA7, ADK
46cysteine447.9ADK, CHRNA7, IFNG, GSR, GZMB, GAD1

GO Terms for genes affiliated with Rasmussen Encephalitis

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Cellular components related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.4SCN2B, SCN1A

Biological processes related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potentialGO:0192289.3CHRNA7, SCN1A
2nucleobase-containing small molecule metabolic processGO:0550869.2GSR, ADK
3sodium ion transmembrane transportGO:0357259.1SCN2B, SCN1A
4positive regulation of T cell proliferationGO:0421029.0ADK, IFNG
5synaptic transmissionGO:0072688.9GAD1, GRIA3, CHRNA7, SCN2B

Products for genes affiliated with Rasmussen Encephalitis

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Sources for Rasmussen Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet