RE
MCID: RSM001
MIFTS: 37

Rasmussen Encephalitis (RE) malady

Summaries for Rasmussen Encephalitis

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42NIH Rare Diseases, 43NINDS, 32MalaCards
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NIH Rare Diseases:42 Rasmussen encephalitis is a chronic inflammatory neurological disease that usually affects only one hemisphere of the brain. it most often occurs in children under the age of 10, although adolescents and adults may also be affected. rasmussen encephalitis is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. while the cause of rasmussen encephalitis is unknown, there is evidence that in many patients it is an autoimmune disorder. immune therapy and surgery may be used for treatment. last updated: 3/22/2012

MalaCards: Rasmussen Encephalitis, also known as rasmussen's encephalitis, is related to encephalitis and prostate cancer. An important gene associated with Rasmussen Encephalitis is GRIA3 (glutamate receptor, ionotropic, AMPA 3), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Circadian entrainment. The compounds pge2 and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and behavior/neurological.

NINDS:43 Rasmussen?s encephalitis is a rare, chronic inflammatory neurological disease that usually affects only one hemisphere of the brain.

Aliases & Classifications for Rasmussen Encephalitis

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42NIH Rare Diseases, 44Novoseek, 43NINDS
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Aliases & Descriptions:

rasmussen encephalitis 42 44
rasmussen's encephalitis 43
re 42


Related Diseases for Rasmussen Encephalitis

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17GeneCards, 18GeneDecks
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Diseases in the Rasmussen Subacute Encephalitis family:

rasmussen encephalitis

Diseases related to Rasmussen Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1030)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis31.5NOS2
2prostate cancer30.7GZMB, BMP6, GSR
3breast cancer30.6GZMB, BMP6, GAD1, IL15, GSR
4leukemia30.6GZMB, BMP6, IL15
5hepatitis30.4IL18, GZMB
6adenocarcinoma30.4CCK, BMP6, SST, NOS2
7pancreatitis30.4SST, CCK
8colorectal cancer30.4IL15, BMP6, GZMB, CCK
9melanoma30.4IL15, BMP6, GZMB
10lung cancer30.3SST
11hepatitis c30.2IL15, IL18, GSR
12vitiligo30.2GSR
13status epilepticus30.2GAD1
14migraine30.1SCN1A
15adenoma30.1GSR, SST
16hepatocellular carcinoma30.1GZMB, BMP6, IL15
17diabetes mellitus30.1CCK, GAD1, SST, GSR
18arthritis30.1GZMB, IL15, IL18, NOS2
19colon cancer30.1BMP6, CHRNA7, IL15, NOS2
20ovarian cancer30.1BMP6
21ischemia30.1GAD1, NOS2, GSR
22malaria30.1GSR
23dementia30.1GSR, CHRNA7
24tuberculosis30.0GSR, IL18, GZMB
25pancreatic cancer30.0IL15, SST, BMP6, CCK
26myeloma30.0IL15
27thyroid cancer30.0SST
28multiple sclerosis30.0GAD1, IL15, IL18, NOS2, GSR
29rheumatoid arthritis30.0GZMB, BMP6, CHRNA7, IL15, IL18, NOS2
30myocardial infarction29.9GSR
31pituitary adenoma29.9SST
32atherosclerosis29.9GZMB, BMP6, IL18, NOS2
33vascular disease29.9GSR, NOS2, BMP6
34alzheimer's disease29.9CCK, GAD1, CHRNA7, SST, NOS2, GSR
35prion disease29.9SCN1A
36peptic ulcer29.9SST, CCK
37glomerulonephritis29.9NOS2, BMP6
38schizophrenia29.9GSR, GRIA3, CHRNA7, GAD1, CCK
39gastritis29.9CCK, SST, NOS2
40primary hyperoxaluria29.8BMP6, IL15, IL18, NOS2, GSR
41gastric ulcer29.8GSR
42schistosomiasis29.8GSR
43constipation29.8CCK
44hepatitis b29.8GSR, GZMB
45peritonitis29.8IL15
46cholera29.8GAD1, CCK
47stomach cancer29.8BMP6, GZMB
48bipolar disorder29.8GAD1, CHRNA7, GRIA3
49celiac disease29.8IL15, GZMB, CCK
50asthma29.8GSR, NOS2, IL18, GZMB

Graphical network of the top 20 diseases related to Rasmussen Encephalitis:



Diseases related to rasmussen encephalitis

Clinical Features for Rasmussen Encephalitis

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Drugs & Therapeutics for Rasmussen Encephalitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Rasmussen Encephalitis

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Search CenterWatch for Rasmussen Encephalitis

Genetic Tests for Rasmussen Encephalitis

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Anatomical Context for Rasmussen Encephalitis

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32MalaCards
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MalaCards organs/tissues related to Rasmussen Encephalitis:

32
Brain

Animal Models for Rasmussen Encephalitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rasmussen Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5IL15, GRIA3, BMP6, SCN1A
2MP:00053867.2SCN2B, GAD1, CHRNA7, GRIA3, SST, IL18
3MP:00036316.9NOS2, IL18, SST, GRIA3, CHRNA7, GAD1
4MP:00053786.4NOS2, IL18, IL15, SST, GRIA3, GAD1

Publications for Rasmussen Encephalitis

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Genetic Variations for Rasmussen Encephalitis

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Expression for genes affiliated with Rasmussen Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rasmussen Encephalitis

Search GEO for disease gene expression data for Rasmussen Encephalitis.

Pathways for genes affiliated with Rasmussen Encephalitis

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52R&D Systems, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Rasmussen Encephalitis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1pge24410.4SST
2cycloheximide4410.4IL18
3prednisolone44 28 1112.3GAD1, GZMB
4h2o2449.8IL18, GAD1
5creatinine449.7BMP6, GAD1, GSR
6taurodeoxycholate449.7SST, CCK
7aspartate449.7CHRNA7, GAD1, BMP6
8valproate449.7GSR, SST, GAD1
9nmda44 2810.6GAD1, CHRNA7, GRIA3, GSR
10oxygen44 2410.6NOS2, CHRNA7, GAD1
11minigastrin449.6CCK, SST
12glutamate449.5GRIA3, CHRNA7, GAD1, CCK
13alosetron44 1110.5SST, CCK
14mptp449.5GAD1, CHRNA7, SST
15tetrodotoxin44 59 2811.5CCK, SCN2B, SCN1A, GAD1
16nitroglycerin44 1110.4SST, NOS2, GSR
17silymarin449.4BMP6, NOS2, GSR
18tacrolimus44 49 1111.2GZMB, BMP6, IL15
19dopamine44 28 11 2412.2CHRNA7, GAD1, BMP6, CCK
20cyclosporin a44 28 5911.1CCK, GZMB, GAD1, IL15
21il 10449.1IL18, IL15, BMP6
22rantes449.0GZMB, BMP6, IL15
23polyinosinic-polycytidylic acid449.0IL15, IL18, NOS2
24atropine44 28 1111.0CCK, CHRNA7, SST
255-hydroxytryptamine449.0SST, CHRNA7, BMP6, CCK
26epinephrine44 11 2410.9GSR, IL18, SST, BMP6
27c-peptide448.9SST, GAD1, CCK
28chloroquine44 2 49 28 1112.9BMP6, IL15, IL18, GSR
29lactate448.9GZMB, BMP6, SST, IL18, GSR
30cyclophosphamide44 49 1110.9SST, IL15, IL18, GSR
31dexamethasone44 49 28 1111.8IL15, BMP6, GZMB, CCK
32isoproterenol44 119.8NOS2, IL18, SST, BMP6
33methotrexate44 49 1110.8BMP6, IL15, IL18, GSR
34sodium nitroprusside448.8CCK, BMP6, SST, NOS2
35ly294002448.7GZMB, BMP6, CHRNA7, IL18, NOS2
365fluorouracil448.6CCK, SST, IL15, IL18
37doxorubicin44 49 1110.6BMP6, SST, IL18, NOS2, GSR
38rapamycin448.4GZMB, BMP6, SST, IL15, IL18
39alanine448.3GZMB, BMP6, GAD1, CHRNA7, IL15, GSR
40cysteine448.3GZMB, GAD1, CHRNA7, IL15, IL18, GSR
41histamine44 28 2410.2IL18, IL15, SST, BMP6, CCK
42gaba448.2CCK, BMP6, GAD1, CHRNA7, GRIA3, SST
43arginine448.1CCK, GZMB, GAD1, SST, IL18, NOS2
44nitric oxide44 11 2410.0GZMB, BMP6, GAD1, IL15, IL18, NOS2
45retinoic acid44 248.8CCK, GZMB, BMP6, SST, IL15, IL18
46adenylate447.8CCK, SST, IL15, IL18, NOS2, GSR
47vegf447.8GZMB, BMP6, SST, IL15, IL18, NOS2
48acetylcholine44 49 28 11 2411.8CCK, BMP6, GAD1, CHRNA7, SST, IL18
49tyrosine447.5CCK, GZMB, BMP6, GAD1, CHRNA7, IL15
50calcium44 49 11 2410.3CCK, GZMB, GAD1, CHRNA7, GRIA3, IL15

GO Terms for genes affiliated with Rasmussen Encephalitis

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16Gene Ontology
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Cellular components related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon initial segmentGO:0431949.5SCN1A, CCK
2voltage-gated sodium channel complexGO:0015189.5SCN1A, SCN2B
3extracellular spaceGO:0056157.8IL18, IL15, SST, BMP6, CCK

Biological processes related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-gammaGO:0713469.5NOS2, IL18
2positive regulation of tissue remodelingGO:0341059.4IL15, IL18
3positive regulation of natural killer cell proliferationGO:0328199.4IL15, IL18
4positive regulation of interleukin-17 productionGO:0327409.2IL18, IL15
5synaptic transmissionGO:0072688.8SST, GRIA3, CHRNA7, GAD1, SCN2B
6response to hypoxiaGO:0016668.8NOS2, IL18, CHRNA7
7inflammatory responseGO:0069548.2BMP6, IL15, IL18, NOS2

Molecular functions related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8IL18, IL15, BMP6

Products for genes affiliated with Rasmussen Encephalitis

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Sources for Rasmussen Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet