RE
MCID: RSM001
MIFTS: 41

Rasmussen Encephalitis (RE) malady

Rare diseases, Neuronal diseases categories
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Summaries for Rasmussen Encephalitis

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43NIH Rare Diseases, 44NINDS, 33MalaCards
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NIH Rare Diseases:43 Rasmussen encephalitis is a chronic inflammatory neurological disease that usually affects only one hemisphere of the brain. it most often occurs in children under the age of 10, although adolescents and adults may also be affected. rasmussen encephalitis is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. while the cause of rasmussen encephalitis is unknown, there is evidence that in many patients it is an autoimmune disorder. immune therapy and surgery may be used for treatment. last updated: 3/22/2012

MalaCards: Rasmussen Encephalitis, also known as rasmussen's encephalitis, is related to encephalitis and scleroderma. An important gene associated with Rasmussen Encephalitis is GRIA3 (glutamate receptor, ionotropic, AMPA 3), and among its related pathways are Glutamic acid signaling and Nicotine addiction. The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and 3-Sulfinoalanine have been mentioned in the context of this disorder. Affiliated tissues include brain and t cells, and related mouse phenotypes are respiratory system and behavior/neurological.

NINDS:44 Rasmussen?s encephalitis is a rare, chronic inflammatory neurological disease that usually affects only one hemisphere of the brain.

Aliases & Classifications for Rasmussen Encephalitis

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43NIH Rare Diseases, 45Novoseek, 44NINDS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

rasmussen encephalitis 43 45
rasmussen's encephalitis 44
re 43


Related Diseases for Rasmussen Encephalitis

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17GeneCards, 18GeneDecks
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Diseases in the Rasmussen Encephalitis family:

Rasmussen Subacute Encephalitis

Diseases related to Rasmussen Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis11.1
2scleroderma10.3
3linear scleroderma10.3
4status epilepticus10.2
5neuronitis10.2
6gliomatosis cerebri10.2
7cerebritis10.2
8vitiligo10.2
9acute intermittent porphyria10.2
10meningitis10.2
11porphyria10.2
12vasculitis10.2
13myoclonus10.2
14limbic encephalitis10.1GAD1
15epilepsy syndrome10.1SCN2B
16alopecia areata10.1GZMB, IFNG
17acute graft versus host disease10.1IFNG, GZMB
18hepatitis10.1GSR, GZMB
19aplastic anemia10.1GZMB, IFNG
20type 1 diabetes mellitus10.1IFNG, GAD1
21sjogren's syndrome10.1GZMB, GAD1
22cutaneous t cell lymphoma10.0GZMB, IFNG
23graft versus host disease10.0GZMB, IFNG
24plasmodium falciparum malaria10.0IFNG, GSR
25autoimmune thyroiditis10.0GAD1, IFNG
26schistosomiasis10.0IFNG, GSR
27lymphopenia10.0GSR, IFNG
28psychotic disorder10.0GAD1, CHRNA7
29autistic disorder10.0CHRNA7, GAD1
30dermatitis10.0IFNG, GZMB
31bipolar disorder10.0GAD1, GRIA3, CHRNA7
32tetanus10.0GAD1, IFNG
33sarcoidosis10.0IFNG, GZMB
34insulinoma10.0GSR, GAD1
35encephalomyelitis10.0GAD1, IFNG
36hepatitis b10.0GZMB, GSR, IFNG
37parkinson's disease10.0GSR, CHRNA7, GAD1
38multiple sclerosis10.0IFNG, GSR, GAD1
39hypersensitivity reaction type ii disease10.0IFNG, GZMB, GAD1
40viral infectious disease10.0IFNG, GAD1, GZMB
41asthma10.0GSR, IFNG, GZMB
42hepatitis c10.0IFNG, GSR
43schizophrenia10.0GAD1, GRIA3, CHRNA7, GSR
44ischemia10.0GSR, GAD1, ADK
45tuberculosis9.9ADK, GSR, IFNG, GZMB

Graphical network of the top 20 diseases related to Rasmussen Encephalitis:



Diseases related to rasmussen encephalitis

Symptoms for Rasmussen Encephalitis

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Drugs & Therapeutics for Rasmussen Encephalitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rasmussen Encephalitis

Search NIH Clinical Center for Rasmussen Encephalitis

Genetic Tests for Rasmussen Encephalitis

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Anatomical Context for Rasmussen Encephalitis

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33MalaCards
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MalaCards organs/tissues related to Rasmussen Encephalitis:

33
Brain, T cells

Animal Models for Rasmussen Encephalitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Rasmussen Encephalitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2GAD1, IFNG, CHRNA7, ADK
2MP:00053867.6SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
3MP:00036317.4SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
4MP:00107686.9GAD1, SCN1A, ADK, CHRNA7, IFNG, GRIA3

Publications for Rasmussen Encephalitis

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52PubMed
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Articles related to Rasmussen Encephalitis:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Rasmussen encephalitis: an unusual cause for intractable seizures in elderly. (24045872)
2014
2
Rasmussen encephalitis. (23622199)
2013
3
Rasmussen encephalitis treated with natalizumab. (23794679)
2013
4
Altered transporter-mediated neocortical GABA release in Rasmussen encephalitis. (23360283)
2013
5
Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia. (23531608)
2013
6
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. (23980696)
2013
7
Differential expression of interferon-I^ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response. (23639073)
2013
8
Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. (23216622)
2013
9
Hemiatrophy and seizures: a case of adult-onset Rasmussen encephalitis. (23315464)
2013
10
Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis. (22309137)
2012
11
Early add-on immunoglobulin administration in Rasmussen encephalitis: the hypothesis of neuroimmunomodulation. (21885203)
2011
12
Bilateral Rasmussen encephalitis. (21216675)
2011
13
Perfusion SPECT findings in a suspected case of Rasmussen encephalitis. (19021826)
2009
14
Diffusion tensor imaging and tractography of Rasmussen encephalitis. (19390848)
2009
15
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (21686702)
2009
16
Dissociation of epileptic and inflammatory activity in Rasmussen Encephalitis. (19121924)
2009
17
CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. (19179379)
2009
18
Adult onset chronic unihemispheric vasculitis resembling Rasmussen encephalitis. (19741437)
2009
19
Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma. (19615863)
2009
20
MRI appearance of Rasmussen encephalitis. (19294372)
2009
21
Rasmussen encephalitis: long-term outcome after surgery. (19153752)
2009
22
Rasmussen encephalitis. (18454904)
2008
23
Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. (18440783)
2008
24
Rasmussen encephalitis associated with SCN 1 A mutation. (18031552)
2008
25
Electrical status epilepticus "invisible" to surface EEG in late-onset Rasmussen encephalitis. (18782691)
2008
26
Acute intermittent porphyria, Rasmussen encephalitis, or both? (17608316)
2007
27
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
28
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (17229752)
2007
29
Parry Romberg syndrome and linear scleroderma en coup de sabre mimicking Rasmussen encephalitis. (18071151)
2007
30
Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizures. (17388985)
2007
31
Parry Romberg syndrome and linear scleroderma in coup de sabre mimicking Rasmussen encephalitis. (17438222)
2007
32
Ictal hemodynamic changes in late-onset rasmussen encephalitis. (16437569)
2006
33
Putaminal involvement in Rasmussen encephalitis. (16710657)
2006
34
Botulinum toxin treatment of facial myoclonus in suspected Rasmussen encephalitis. (16758485)
2006
35
Neuropathological spectrum of Rasmussen encephalitis. (16010051)
2005
36
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. (15689357)
2005
37
An open study of tacrolimus therapy in Rasmussen encephalitis. (15184626)
2004
38
Rasmussen encephalitis. (15096412)
2004
39
Longitudinal study of MRS metabolites in Rasmussen encephalitis. (15069020)
2004
40
Rasmussen encephalitis with active inflammation and delayed seizures onset. (15037707)
2004
41
Late language transfer in patients with Rasmussen encephalitis. (12790905)
2003
42
Rasmussen encephalitis associated with Parry-Romberg syndrome. (12913207)
2003
43
MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. (12558582)
2003
44
Bilateral Rasmussen encephalitis: postmortem documentation in a five-year-old. (12581240)
2003
45
Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. (12090428)
2002
46
Ultrastructural study of Rasmussen encephalitis. (12396238)
2002
47
Magnetic resonance and positron emission tomography changes during the clinical progression of Rasmussen encephalitis. (10800268)
2000
48
Evidence for glutamate receptor autoimmunity in the pathogenesis of Rasmussen encephalitis. (10514842)
1999
49
Rasmussen encephalitis in childhood. (10447611)
1999
50
Rasmussen encephalitis: complementary role of multitechnique neuroimaging. (9541296)
1998

Variations for Rasmussen Encephalitis

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Expression for genes affiliated with Rasmussen Encephalitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rasmussen Encephalitis

Search GEO for disease gene expression data for Rasmussen Encephalitis.

Pathways for genes affiliated with Rasmussen Encephalitis

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50PathCards, 12EMD Millipore, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN
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Pathways related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8GAD1, GRIA3
29.6CHRNA7, GRIA3
39.6GRIA3, CHRNA7
4
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.6GZMB, IFNG
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.6GZMB, IFNG
6
Show member pathways
9.6IFNG, GZMB
7
Show member pathways
9.6GZMB, IFNG
8
Show member pathways
thioredoxin pathway38
9.5GSR, IFNG
99.4SCN2B, SCN1A
109.4SCN2B, SCN1A
11
Show member pathways
9.3GAD1, GRIA3, CHRNA7
12
Show member pathways
purine deoxyribonucleosides degradation38
purine nucleotides degradation38
adenine and adenosine salvage II38
adenine and adenosine salvage III38
oxidized GTP and dGTP detoxification38
urate biosynthesis/inosine 5-phosphate degradation38
adenine and adenosine salvage I38
purine ribonucleosides degradation to ribose-1-phosphate38
inosine-5-phosphate biosynthesis38
guanosine nucleotides degradation38
guanine and guanosine salvage38
adenosine nucleotides degradation38
5-aminoimidazole ribonucleotide biosynthesis38
9.2GSR, ADK
13
Show member pathways
9.2IFNG, GZMB, GAD1
14
Show member pathways
9.1GRIA3, SCN2B, SCN1A
15
Show member pathways
8.6GAD1, GRIA3, CHRNA7, SCN1A

Compounds for genes affiliated with Rasmussen Encephalitis

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45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4510.1GSR, GRIA3
23-Sulfinoalanine24 1111.1GAD1, GSR
3chromium4510.1GZMB, GSR
4thiamine45 3 24 1113.0GAD1, GSR
5alpha-galactosylceramide4510.0IFNG, GZMB
6pentobarbital45 1111.0GRIA3, CHRNA7
7vitamin b64510.0GAD1, GSR
8valproate459.9GSR, GAD1
9bicuculline45 2910.9CHRNA7, GAD1
10d penicillamine459.9GSR, IFNG
11concanamycin a45 6110.9GZMB, IFNG
12ebselen459.9GSR, IFNG
13auranofin29 45 61 1112.9IFNG, GSR
14gsno459.8IFNG, GSR
15ivig459.8GZMB, IFNG
16mptp459.8GAD1, CHRNA7
17kynurenine459.8CHRNA7, IFNG
18qx 314 chloride619.8SCN1A, SCN2B
19tetrodotoxin citrate619.8SCN1A, SCN2B
20l-glutamic acid29 24 1111.8GSR, GRIA3, GAD1
21phrixotoxin 3619.8SCN1A, SCN2B
22veratridine45 61 2911.8SCN2B, SCN1A
23zonisamide45 51 1111.7SCN1A, SCN2B
24menadione45 24 1111.7GSR, IFNG
25prednisolone45 29 1111.6IFNG, GZMB, GAD1
26melphalan45 51 1111.6GSR, IFNG
27neopterin459.6IFNG, GZMB
28carbamazepine45 51 1111.6GSR, SCN1A
29clozapine45 29 51 1112.6GAD1, CHRNA7
30tetrodotoxin45 61 2911.5SCN1A, SCN2B, GAD1
31carboplatin45 51 1111.4GSR, IFNG
32ribavirin45 51 1111.3ADK, IFNG
33gaba459.3CHRNA7, GSR, GRIA3, GAD1
34aspartate459.2CHRNA7, GSR, GZMB, GAD1
35pge2459.2GSR, IFNG, CHRNA7
36tacrolimus45 51 1111.2ADK, IFNG, GZMB
37alanine459.2CHRNA7, GSR, GZMB, GAD1
38kainate45 2910.0ADK, GSR, GRIA3, GAD1
39glucose 6-phosphate45 249.9GSR, ADK
40glutamate458.9GAD1, GZMB, GRIA3, GSR, CHRNA7
41potassium45 24 1110.9GAD1, ADK, SCN1A
42cyclosporin a45 29 6110.8GAD1, GZMB, IFNG, ADK
43nmda45 299.5GAD1, GRIA3, GSR, CHRNA7, ADK
44arginine458.4ADK, IFNG, GSR, GZMB, GAD1
45oxygen45 249.4GAD1, GZMB, GSR, CHRNA7, ADK
46cysteine457.9ADK, CHRNA7, IFNG, GSR, GZMB, GAD1

GO Terms for genes affiliated with Rasmussen Encephalitis

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16Gene Ontology
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Cellular components related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.4SCN2B, SCN1A

Biological processes related to Rasmussen Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potentialGO:0192289.3CHRNA7, SCN1A
2nucleobase-containing small molecule metabolic processGO:0550869.2GSR, ADK
3sodium ion transmembrane transportGO:0357259.1SCN2B, SCN1A
4positive regulation of T cell proliferationGO:0421029.0ADK, IFNG
5synaptic transmissionGO:0072688.9GAD1, GRIA3, CHRNA7, SCN2B

Products for genes affiliated with Rasmussen Encephalitis

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Sources for Rasmussen Encephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet