MCID: RSM001
MIFTS: 36

Rasmussen Encephalitis malady

Rare diseases, Neuronal diseases categories

Summaries for Rasmussen Encephalitis

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NIH Rare Diseases:41 Rasmussen encephalitis is a chronic inflammatory neurological disease that usually affects only one hemisphere of the brain. it most often occurs in children under the age of 10, although adolescents and adults may also be affected. rasmussen encephalitis is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. while the cause of rasmussen encephalitis is unknown, there is evidence that in many patients it is an autoimmune disorder. immune therapy and surgery may be used for treatment. last updated: 3/22/2012

MalaCards based summary: Rasmussen Encephalitis, also known as rasmussen's encephalitis, is related to epilepsy syndrome and encephalitis. An important gene associated with Rasmussen Encephalitis is GRIA3 (glutamate receptor, ionotropic, AMPA 3), and among its related pathways are Glutamic acid signaling and Nicotine addiction. The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and 3-Sulfinoalanine have been mentioned in the context of this disorder. Affiliated tissues include brain and t cells, and related mouse phenotypes are respiratory system and behavior/neurological.

NINDS:42 Rasmussen?s encephalitis is a rare, chronic inflammatory neurological disease that usually affects only one hemisphere of the brain.

Aliases & Classifications for Rasmussen Encephalitis

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS, 42NINDS
See all sources

Rasmussen Encephalitis, Aliases & Descriptions:

Name: Rasmussen Encephalitis 41 43
Rasmussen's Encephalitis 42
 
Rasmussen Syndrome 60
Re 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Rasmussen Encephalitis

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Diseases in the Rasmussen Encephalitis family:

Rasmussen Subacute Encephalitis

Diseases related to Rasmussen Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome30.9SCN2B
2encephalitis11.1
3limbic encephalitis10.5GAD1
4neuronitis10.3
5scleroderma10.3
6linear scleroderma10.3
7alopecia areata10.2GZMB, IFNG
8acute graft versus host disease10.2GZMB, IFNG
9hepatitis10.2GZMB, GSR
10aplastic anemia10.2GZMB, IFNG
11diabetes mellitus, insulin-dependent10.2GAD1, IFNG
12sjogren's syndrome10.2GAD1, GZMB
13cutaneous t cell lymphoma10.2GZMB, IFNG
14graft-versus-host disease, protection against10.2GZMB, IFNG
15plasmodium falciparum malaria10.2GSR, IFNG
16hashimoto thyroiditis10.2GAD1, IFNG
17schistosomiasis10.2GSR, IFNG
18lymphopenia10.2IFNG, GSR
19psychotic disorder10.2CHRNA7, GAD1
20status epilepticus10.2
21gliomatosis cerebri10.2
22tuberous sclerosis10.2
23cerebritis10.2
24meningitis10.2
25porphyria10.2
26vasculitis10.2
27febrile infection-related epilepsy syndrome10.2
28weber syndrome10.2
29myoclonus10.2
30autistic disorder10.2GAD1, CHRNA7
31dermatitis10.1IFNG, GZMB
32alcohol dependence10.1GAD1, GSR
33bipolar disorder10.1CHRNA7, GRIA3, GAD1
34tetanus10.1GAD1, IFNG
35insulinoma10.1GAD1, GSR
36hepatitis b10.1IFNG, GSR, GZMB
37hepatitis c10.1GSR, IFNG
38parkinson disease, late-onset10.0GAD1, GSR, CHRNA7
39multiple sclerosis, disease progression, modifier of10.0IFNG, GSR, GAD1
40hypersensitivity reaction type ii disease10.0GAD1, GZMB, IFNG
41viral infectious disease10.0IFNG, GZMB, GAD1
42asthma10.0GZMB, GSR, IFNG
43sarcoidosis 19.9GZMB, IFNG
44schizophrenia9.9GAD1, GRIA3, GSR, CHRNA7
45ischemia9.9GAD1, GSR, ADK
46tuberculosis9.7GZMB, GSR, IFNG, ADK

Graphical network of the top 20 diseases related to Rasmussen Encephalitis:



Diseases related to rasmussen encephalitis

Symptoms for Rasmussen Encephalitis

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Drugs & Therapeutics for Rasmussen Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Rasmussen Encephalitis

Search NIH Clinical Center for Rasmussen Encephalitis

Genetic Tests for Rasmussen Encephalitis

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Anatomical Context for Rasmussen Encephalitis

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MalaCards organs/tissues related to Rasmussen Encephalitis:

31
Brain, T cells

Animal Models for Rasmussen Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Rasmussen Encephalitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2GAD1, IFNG, CHRNA7, ADK
2MP:00053867.6SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
3MP:00036317.4SCN1A, SCN2B, CHRNA7, IFNG, GRIA3, GAD1
4MP:00107686.9GAD1, SCN1A, ADK, CHRNA7, IFNG, GRIA3

Publications for Rasmussen Encephalitis

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Articles related to Rasmussen Encephalitis:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). (24639375)
2014
2
Voltage-gated potassium channels autoantibodies in a child with rasmussen encephalitis. (25062271)
2014
3
Surgical treatment of patients with Rasmussen encephalitis. (24503650)
2014
4
Hemispherotomy in Rasmussen encephalitis: long-term outcome in an Italian series of 16 patients. (24815913)
2014
5
Exceptional verbal intelligence after hemispherotomy in a child with Rasmussen encephalitis. (24471481)
2014
6
Editorial comment: The janus of Rasmussen encephalitis: never a friendly face. (25149948)
2014
7
Transition into adulthood: tuberous sclerosis complex, Sturge-Weber syndrome, and Rasmussen encephalitis. (25209083)
2014
8
Rasmussen encephalitis. (23622199)
2013
9
Rasmussen encephalitis treated with natalizumab. (23794679)
2013
10
Altered transporter-mediated neocortical GABA release in Rasmussen encephalitis. (23360283)
2013
11
Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia. (23531608)
2013
12
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. (23980696)
2013
13
Differential expression of interferon-I^ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response. (23639073)
2013
14
Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. (23216622)
2013
15
Hemiatrophy and seizures: a case of adult-onset Rasmussen encephalitis. (23315464)
2013
16
Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis. (22309137)
2012
17
Early add-on immunoglobulin administration in Rasmussen encephalitis: the hypothesis of neuroimmunomodulation. (21885203)
2011
18
Bilateral Rasmussen encephalitis. (21216675)
2011
19
Perfusion SPECT findings in a suspected case of Rasmussen encephalitis. (19021826)
2009
20
Diffusion tensor imaging and tractography of Rasmussen encephalitis. (19390848)
2009
21
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (21686702)
2009
22
Dissociation of epileptic and inflammatory activity in Rasmussen Encephalitis. (19121924)
2009
23
CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. (19179379)
2009
24
Adult onset chronic unihemispheric vasculitis resembling Rasmussen encephalitis. (19741437)
2009
25
Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma. (19615863)
2009
26
Rasmussen encephalitis. (18454904)
2008
27
Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. (18440783)
2008
28
Rasmussen encephalitis associated with SCN 1 A mutation. (18031552)
2008
29
Acute intermittent porphyria, Rasmussen encephalitis, or both? (17608316)
2007
30
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
31
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (17229752)
2007
32
Parry Romberg syndrome and linear scleroderma en coup de sabre mimicking Rasmussen encephalitis. (18071151)
2007
33
Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizures. (17388985)
2007
34
Parry Romberg syndrome and linear scleroderma in coup de sabre mimicking Rasmussen encephalitis. (17438222)
2007
35
Ictal hemodynamic changes in late-onset rasmussen encephalitis. (16437569)
2006
36
Putaminal involvement in Rasmussen encephalitis. (16710657)
2006
37
Neuropathological spectrum of Rasmussen encephalitis. (16010051)
2005
38
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. (15689357)
2005
39
An open study of tacrolimus therapy in Rasmussen encephalitis. (15184626)
2004
40
Rasmussen encephalitis. (15096412)
2004
41
Longitudinal study of MRS metabolites in Rasmussen encephalitis. (15069020)
2004
42
Rasmussen encephalitis with active inflammation and delayed seizures onset. (15037707)
2004
43
Late language transfer in patients with Rasmussen encephalitis. (12790905)
2003
44
Rasmussen encephalitis associated with Parry-Romberg syndrome. (12913207)
2003
45
MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. (12558582)
2003
46
Bilateral Rasmussen encephalitis: postmortem documentation in a five-year-old. (12581240)
2003
47
Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. (12090428)
2002
48
Ultrastructural study of Rasmussen encephalitis. (12396238)
2002
49
Magnetic resonance and positron emission tomography changes during the clinical progression of Rasmussen encephalitis. (10800268)
2000
50
Rasmussen encephalitis in childhood. (10447611)
1999

Variations for Rasmussen Encephalitis

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Expression for genes affiliated with Rasmussen Encephalitis

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Search GEO for disease gene expression data for Rasmussen Encephalitis.

Pathways for genes affiliated with Rasmussen Encephalitis

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Pathways related to Rasmussen Encephalitis according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CHRNA7, GRIA3
2
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.6GZMB, IFNG
3
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.6GZMB, IFNG
4
Show member pathways
9.6IFNG, GZMB
5
Show member pathways
9.6GZMB, IFNG
6
Show member pathways
thioredoxin pathway36
9.5GSR, IFNG
79.4SCN2B, SCN1A
8
Show member pathways
9.3GAD1, GRIA3, CHRNA7
9
Show member pathways
purine deoxyribonucleosides degradation36
purine nucleotides degradation36
adenine and adenosine salvage II36
adenine and adenosine salvage III36
oxidized GTP and dGTP detoxification36
urate biosynthesis/inosine 5-phosphate degradation36
adenine and adenosine salvage I36
purine ribonucleosides degradation to ribose-1-phosphate36
inosine-5-phosphate biosynthesis36
guanosine nucleotides degradation36
guanine and guanosine salvage36
adenosine nucleotides degradation36
5-aminoimidazole ribonucleotide biosynthesis36
9.2GSR, ADK
10
Show member pathways
9.2IFNG, GZMB, GAD1
11
Show member pathways
9.1GRIA3, SCN2B, SCN1A
12
Show member pathways
8.6GAD1, GRIA3, CHRNA7, SCN1A

Compounds for genes affiliated with Rasmussen Encephalitis

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Compounds related to Rasmussen Encephalitis according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4310.1GSR, GRIA3
23-Sulfinoalanine24 1211.1GAD1, GSR
3chromium4310.1GZMB, GSR
4thiamine43 2 24 1213.0GAD1, GSR
5alpha-galactosylceramide4310.0IFNG, GZMB
6pentobarbital43 1211.0GRIA3, CHRNA7
7vitamin b64310.0GAD1, GSR
8valproate439.9GSR, GAD1
9bicuculline43 2810.9CHRNA7, GAD1
10d penicillamine439.9GSR, IFNG
11concanamycin a43 5910.9GZMB, IFNG
12ebselen439.9GSR, IFNG
13auranofin28 43 59 1212.9IFNG, GSR
14gsno439.8IFNG, GSR
15ivig439.8GZMB, IFNG
16mptp439.8GAD1, CHRNA7
17kynurenine439.8CHRNA7, IFNG
18qx 314 chloride599.8SCN1A, SCN2B
19tetrodotoxin citrate599.8SCN1A, SCN2B
20l-glutamic acid28 24 1211.8GSR, GRIA3, GAD1
21phrixotoxin 3599.8SCN1A, SCN2B
22veratridine43 59 2811.8SCN2B, SCN1A
23zonisamide43 49 1211.7SCN1A, SCN2B
24menadione43 24 1211.7GSR, IFNG
25prednisolone43 28 1211.6IFNG, GZMB, GAD1
26melphalan43 49 1211.6GSR, IFNG
27neopterin439.6IFNG, GZMB
28carbamazepine43 49 1211.6GSR, SCN1A
29clozapine43 28 49 1212.6GAD1, CHRNA7
30tetrodotoxin43 59 2811.5SCN1A, SCN2B, GAD1
31carboplatin43 49 1211.4GSR, IFNG
32ribavirin43 49 1211.3ADK, IFNG
33gaba439.3CHRNA7, GSR, GRIA3, GAD1
34aspartate439.2CHRNA7, GSR, GZMB, GAD1
35pge2439.2GSR, IFNG, CHRNA7
36tacrolimus43 49 1211.2ADK, IFNG, GZMB
37alanine439.2CHRNA7, GSR, GZMB, GAD1
38kainate43 2810.0ADK, GSR, GRIA3, GAD1
39glucose 6-phosphate43 249.9GSR, ADK
40glutamate438.9GAD1, GZMB, GRIA3, GSR, CHRNA7
41potassium43 24 1210.9GAD1, ADK, SCN1A
42cyclosporin a43 28 5910.8GAD1, GZMB, IFNG, ADK
43nmda43 289.5GAD1, GRIA3, GSR, CHRNA7, ADK
44arginine438.4ADK, IFNG, GSR, GZMB, GAD1
45oxygen43 249.4GAD1, GZMB, GSR, CHRNA7, ADK
46cysteine437.9ADK, CHRNA7, IFNG, GSR, GZMB, GAD1

GO Terms for genes affiliated with Rasmussen Encephalitis

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Cellular components related to Rasmussen Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.4SCN2B, SCN1A

Biological processes related to Rasmussen Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potentialGO:00192289.3CHRNA7, SCN1A
2nucleobase-containing small molecule metabolic processGO:00550869.2GSR, ADK
3sodium ion transmembrane transportGO:00357259.1SCN2B, SCN1A
4positive regulation of T cell proliferationGO:00421029.0ADK, IFNG
5synaptic transmissionGO:00072688.9GAD1, GRIA3, CHRNA7, SCN2B

Products for genes affiliated with Rasmussen Encephalitis

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Sources for Rasmussen Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet