MCID: RSM001
MIFTS: 42

Rasmussen Encephalitis malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Rasmussen Encephalitis

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Aliases & Descriptions for Rasmussen Encephalitis:

Name: Rasmussen Encephalitis 45 47
Rasmussen's Encephalitis 46
 
Rasmussen Syndrome 65
Re 45

Classifications:



External Ids:

UMLS65 C0393484

Summaries for Rasmussen Encephalitis

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NIH Rare Diseases:45 Rasmussen encephalitis is a chronic inflammatory neurological disease that usually affects only one hemisphere of the brain. it most often occurs in children under the age of 10, although adolescents and adults may also be affected. rasmussen encephalitis is characterized by frequent and severe seizures, loss of motor skills and speech, paralysis on one side of the body (hemiparesis), inflammation of the brain (encephalitis), and mental deterioration. while the cause of rasmussen encephalitis is unknown, there is evidence that in many patients it is an autoimmune disorder. immune therapy and surgery may be used for treatment. last updated: 3/22/2012

MalaCards based summary: Rasmussen Encephalitis, also known as rasmussen's encephalitis, is related to encephalitis and pancreatic cystadenocarcinoma, and has symptoms including seizures An important gene associated with Rasmussen Encephalitis is GRIA3 (Glutamate Ionotropic Receptor AMPA Type Subunit 3), and among its related pathways are Nicotine addiction and African trypanosomiasis. Affiliated tissues include brain, prostate and bone, and related mouse phenotypes are no phenotypic analysis and nervous system.

NINDS:46 Rasmussen?s encephalitis is a rare, chronic inflammatory neurological disease that usually affects only one hemisphere of the brain.

Related Diseases for Rasmussen Encephalitis

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Diseases in the Rasmussen Encephalitis family:

Rasmussen Subacute Encephalitis

Diseases related to Rasmussen Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis10.9
2pancreatic cystadenocarcinoma10.5CCK, SST
3biliary tract disease10.5CCK, SST
4dentin sensitivity10.4CCK, SST
5cow milk allergy10.4IFNG, IL18
6bladder lateral wall cancer10.4CCK, SST
7glucose intolerance10.4CCK, SST
8female breast cancer10.3GAD1, IL18
9chronic tic disorder10.3IFNG, IL18
10metabolic acidosis10.3GZMB, IL18
11hepatoid adenocarcinoma10.2IFNG, IL18
12hypersensitivity reaction type iv disease10.2CCK, IL18, SST
13acute leukemia of ambiguous lineage10.2IFNG, IL18
14infiltrating bladder lymphoepithelioma-like carcinoma10.1CCK, SST
15infertility10.1GZMB, IFNG
16small intestine cancer10.1GZMB, SST
17neuronitis10.0
18linear scleroderma10.0
19rectum signet ring adenocarcinoma10.0CCK, IL15, SST
20diamond-blackfan anemia 310.0BMP6, IFNG, IL18
21inflammatory bowel disease 310.0IFNG, IL15, IL18
22meige syndrome9.9IFNG, IL15
23porphyria9.9
24tuberous sclerosis9.9
25status epilepticus9.9
26epilepsy syndrome9.9
27cerebritis9.9
28gliomatosis cerebri9.9
29vasculitis9.9
30meningitis9.9
31febrile infection-related epilepsy syndrome9.9
32weber syndrome9.9
33myoclonus9.9
34mitochondrial metabolism disease9.9IFNG, IL15, SST
35astrakhan spotted fever9.8IFNG, IL15
36linear and whorled nevoid hypermelanosis9.7GAD1, GSR
37sarcoidosis 19.6GZMB, IFNG, IL15
38schizophrenia9.4CCK, CHRNA7, GAD1, GRIA3, SST
39hypocalciuric hypercalcemia, type i9.3IFNG, IL15, IL18
40hepatic adenoma, somatic9.1GAD1, IFNG, IL15, IL18, SST
41malaria9.0GSR, IFNG, IL15, IL18
42rasmussen johnsen thomsen syndrome5.9ADK, BMP6, CCK, CHRNA7, GAD1, GRIA3

Graphical network of the top 20 diseases related to Rasmussen Encephalitis:



Diseases related to rasmussen encephalitis

Symptoms for Rasmussen Encephalitis

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UMLS symptoms related to Rasmussen Encephalitis:


seizures

Drugs & Therapeutics for Rasmussen Encephalitis

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Drugs for Rasmussen Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tacrolimusapproved, investigationalPhase 2, Phase 31023104987-11-3445643, 439492, 445647
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
8-DEETHYL-8-[but-3-enyl]-ascomycin
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
FR900506
 
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
Hecoria
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus Hydrate
Tacrolimus anhydrous
Tacrolimus hydrate
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
2Immunologic FactorsPhase 2, Phase 3, Phase 118483
3Rho(D) Immune GlobulinPhase 2, Phase 3206
4Calcineurin InhibitorsPhase 2, Phase 31223
5ImmunoglobulinsPhase 2, Phase 34477
6Immunosuppressive AgentsPhase 2, Phase 310422
7AntibodiesPhase 2, Phase 34477
8Immunoglobulins, IntravenousPhase 2, Phase 3211
9
rituximabapprovedPhase 11582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
10Antirheumatic AgentsPhase 18496

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Tacrolimus and I.V.-Immunoglobulins in Rasmussen EncephalitisActive, not recruitingNCT00545493Phase 2, Phase 3
2A Pilot Study of the Use of Rituximab in the Treatment of Chronic Focal EncephalitisCompletedNCT00259805Phase 1

Search NIH Clinical Center for Rasmussen Encephalitis

Genetic Tests for Rasmussen Encephalitis

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Anatomical Context for Rasmussen Encephalitis

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MalaCards organs/tissues related to Rasmussen Encephalitis:

33
Brain, Prostate, Bone, Endothelial, T cells, Monocytes, B cells

Animal Models for Rasmussen Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Rasmussen Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.0CCK, CHRNA7, GAD1, GRIA3, IFNG, SST
2MP:00036317.3CCK, CHRNA7, GAD1, GRIA3, IFNG, IL18
3MP:00053866.9CCK, CHRNA7, GAD1, GRIA3, IFNG, IL15
4MP:00053786.7ADK, BMP6, CHRNA7, GAD1, GRIA3, IFNG

Publications for Rasmussen Encephalitis

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Articles related to Rasmussen Encephalitis:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Absence of seizures in Rasmussen encephalitis with active inflammation. (26775150)
2016
2
Transcranial direct current stimulation improves seizure control in patients with Rasmussen encephalitis. (26842560)
2016
3
Evidence for Resident Memory T Cells in Rasmussen Encephalitis. (26941743)
2016
4
CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing. (27040081)
2016
5
Rethinking the Magnetic Resonance Imaging Findings inA EarlyA Rasmussen Encephalitis: A Case Report and Review ofA theA Literature. (27004940)
2015
6
Pediatric anti-Hu-associated encephalitis with clinical features of Rasmussen encephalitis. (26445726)
2015
7
Crossed Cerebellar Diaschisis Due to Rasmussen Encephalitis. (26105956)
2015
8
Language recovery after left hemispherotomy for Rasmussen encephalitis. (26519666)
2015
9
Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). (24639375)
2014
10
Voltage-gated potassium channels autoantibodies in a child with rasmussen encephalitis. (25062271)
2014
11
Surgical treatment of patients with Rasmussen encephalitis. (24503650)
2014
12
Hemispherotomy in Rasmussen encephalitis: long-term outcome in an Italian series of 16 patients. (24815913)
2014
13
Exceptional verbal intelligence after hemispherotomy in a child with Rasmussen encephalitis. (24471481)
2014
14
Editorial comment: The janus of Rasmussen encephalitis: never a friendly face. (25149948)
2014
15
Rasmussen encephalitis. (23622199)
2013
16
Rasmussen encephalitis treated with natalizumab. (23794679)
2013
17
Altered transporter-mediated neocortical GABA release in Rasmussen encephalitis. (23360283)
2013
18
Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia. (23531608)
2013
19
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. (23980696)
2013
20
Differential expression of interferon-I^ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response. (23639073)
2013
21
Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. (23216622)
2013
22
Hemiatrophy and seizures: a case of adult-onset Rasmussen encephalitis. (23315464)
2013
23
Early add-on immunoglobulin administration in Rasmussen encephalitis: the hypothesis of neuroimmunomodulation. (21885203)
2011
24
Bilateral Rasmussen encephalitis. (21216675)
2011
25
Perfusion SPECT findings in a suspected case of Rasmussen encephalitis. (19021826)
2009
26
Diffusion tensor imaging and tractography of Rasmussen encephalitis. (19390848)
2009
27
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (21686702)
2009
28
Dissociation of epileptic and inflammatory activity in Rasmussen Encephalitis. (19121924)
2009
29
CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. (19179379)
2009
30
Adult onset chronic unihemispheric vasculitis resembling Rasmussen encephalitis. (19741437)
2009
31
Rasmussen encephalitis. (18454904)
2008
32
Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. (18440783)
2008
33
Acute intermittent porphyria, Rasmussen encephalitis, or both? (17608316)
2007
34
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
35
Rasmussen encephalitis with ipsilateral brain stem involvement in an adult patient. (17229752)
2007
36
Parry Romberg syndrome and linear scleroderma en coup de sabre mimicking Rasmussen encephalitis. (18071151)
2007
37
Ictal hemodynamic changes in late-onset rasmussen encephalitis. (16437569)
2006
38
Putaminal involvement in Rasmussen encephalitis. (16710657)
2006
39
Neuropathological spectrum of Rasmussen encephalitis. (16010051)
2005
40
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. (15689357)
2005
41
An open study of tacrolimus therapy in Rasmussen encephalitis. (15184626)
2004
42
Rasmussen encephalitis. (15096412)
2004
43
Longitudinal study of MRS metabolites in Rasmussen encephalitis. (15069020)
2004
44
Rasmussen encephalitis with active inflammation and delayed seizures onset. (15037707)
2004
45
Late language transfer in patients with Rasmussen encephalitis. (12790905)
2003
46
Rasmussen encephalitis associated with Parry-Romberg syndrome. (12913207)
2003
47
Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. (12090428)
2002
48
Magnetic resonance and positron emission tomography changes during the clinical progression of Rasmussen encephalitis. (10800268)
2000
49
Evidence for glutamate receptor autoimmunity in the pathogenesis of Rasmussen encephalitis. (10514842)
1999
50

Variations for Rasmussen Encephalitis

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Expression for genes affiliated with Rasmussen Encephalitis

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Search GEO for disease gene expression data for Rasmussen Encephalitis.

Pathways for genes affiliated with Rasmussen Encephalitis

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GO Terms for genes affiliated with Rasmussen Encephalitis

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Biological processes related to Rasmussen Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:003410510.3IL15, IL18
2positive regulation of natural killer cell proliferationGO:003281910.3IL15, IL18
3cell-cell signalingGO:00072679.4IL15, IL18, SST
4inflammatory responseGO:00069549.2BMP6, IL15, IL18
5immune responseGO:00069558.8BMP6, IFNG, IL15, IL18

Sources for Rasmussen Encephalitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet