PIRA
MCID: RCT015
MIFTS: 58

Reactive Arthritis (PIRA) malady

Bone, Gastrointestinal categories

Summaries for Reactive Arthritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and psoriatic arthritis, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, hyperkeratosis/ainhum/hyperkeratotic skin fissures and pustula/pustulosis. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds ccl3 and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spinal cord and heart.

Disease Ontology:8 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia:64 Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in... more...

Aliases & Classifications for Reactive Arthritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone, Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
reactive arthritis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

reactive arthritis 8 43 10 49
reiter syndrome 43 49 61
post-infectious reactive arthropathy 43
fiessinger-leroy-reiter syndrome 49
fiessinger leroy reiter syndrome 8
post-dysenteric arthropathy 61
post-bacterial arthropathy 8
postdysenteric arthropathy 8
post-infectious arthritis 43
fiessinger-leroy disease 49
polyarteritis enterica 49
arthritis urethritica 49
arthritis, reactive 61
arthritis, venereal 61
arthritis reactive 45
venereal arthritis 49
reiter's syndrome 43
reiters syndrome 45
reiter's disease 8
reiter disease 8
pira 43


External Ids:

Disease Ontology8 DOID:6196
ICD9CM27 099.3
NCIt40 C34975
MeSH35 D016918
UMLS via Orphanet62 C0085435, C0035012
MESH via Orphanet36 D016918
ICD10 via Orphanet26 M02.8
SNOMED-CT via Orphanet58 129133005, 236690002, 239783001 67224007, more
ICD1025 M02.1, M02.3

Related Diseases for Reactive Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.9SLC11A1, COMP, S100A12, MRAP, CXCL5, IL17A
2psoriatic arthritis30.5MRAP
3osteoarthritis30.4CXCL5, MMP8, CEACAM8, IL17A, IL21, COMP
4vasculitis30.3S100A12, IL17A
5synovitis30.1MMP8, IL17A, COMP
6ulcerative colitis29.9CXCL5, IL21, SLC11A1, IL17A
7trachoma10.7
8ankylosing spondylitis10.6
9spondylitis10.6
10rheumatic fever10.5
11clostridium difficile10.5
12septic arthritis10.4
13spondyloarthropathy10.3
14uveitis10.3
15urethritis10.3
16tuberculosis10.3
17bladder carcinoma10.2
18tetanus10.2
19proctitis10.1
20systemic lupus erythematosus10.1
21hidradenitis suppurativa10.1
22tonsillitis10.1
23bacteremia10.1
24rheumatic disease10.1
25crohn's disease10.0
26choroiditis10.0
27multifocal choroiditis10.0
28spondylarthropathy10.0
29meningitis10.0OMP
30hypersensitivity reaction type ii disease10.0IL17A, TRH
31sarcoidosis10.0SLC11A1, CXCL5
32malaria10.0SLC11A1
33leukemia10.0CCR1, IL17A
34inflammatory bowel disease10.0MRAP, S100A12
35leishmaniasis10.0SLC11A1
36atherosclerosis10.0MMP8, IL17A, CCL15, COMP
37periodontitis10.0OMP, IL17A, MMP8
38funisitis10.0MMP8
39cork-handlers' disease10.0IL17A, MMP8, CXCL5, SLC11A1
40obesity10.0IL17A, TRH, COMP
41neisseria meningitidis infection10.0OMP, ROM1
42multiple sclerosis10.0MMP8, SLC11A1, CCR1, IL17A
43peritonitis10.0MMP8
44asthma10.0SLC11A1, MMP8, IL17A, CXCL5, S100A12, CCR1
45encephalomyelitis10.0CCR1, IL17A, IL21
46rheumatoid arthritis10.0SLC11A1, MMP8, IL17A, IL21, CXCL5, COMP
47melanoma10.0KLRB1, CXCL5, IL21, CCR1
48viral infectious disease10.0CCR1, CXCL5, IL17A, SLC11A1
49psoriasis10.0IL17A, S100A12, MRAP
50keratitis10.0IL17A

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to reactive arthritis

Clinical Features for Reactive Arthritis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 28)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • pustula/pustulosis
  • enanthema/aphtosa/aphta/leukoplakia
  • nails anomalies
  • dysplastic/thick/grooved fingernails
  • malabsorption/chronic diarrhea/steatorrhea
  • urethral anomalies/stenosis/posterior urethral valves/megalocystis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • cartilage destruction/chondrolysis
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • acute abdominal pain/colic
  • inflammatory intestinal disease
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • photophobia
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • recurrent urinary infections
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling

Drugs & Therapeutics for Reactive Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Reactive Arthritis

Drug clinical trials:

Search ClinicalTrials for Reactive Arthritis

Search NIH Clinical Center for Reactive Arthritis

Search CenterWatch for Reactive Arthritis

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Reactive Arthritis:

33
Whole blood, Spinal cord, Heart, Small intestine, Kidney, Liver, Thyroid, Breast, Skin, Tonsil, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Reactive Arthritis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Reactive Arthritis

Sources:
51PubMed
See all sources

Articles related to Reactive Arthritis:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
Chlamydia-induced reactive arthritis: hidden in plain sight? (22100286)
2011
2
Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis. (21325757)
2011
3
Prolonged remission of chronic reactive arthritis treated with three infusions of infliximab. (20216128)
2010
4
Reactive arthritis associated with hidradenitis suppurativa. (19397229)
2009
5
Reactive arthritis due to Chlamydia psittaci associated with HLA-B27 genotype. (19485846)
2009
6
MHC class I and class II genes in Tunisian patients with reactive and undifferentiated arthritis. (19473559)
2009
7
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new? (19519922)
2009
8
Antibacterial antibodies for some enterobacteria in sera of patients with reactive arthritis and other rheumatoid diseases. (19284164)
2008
9
Correlation between C reactive protein and erythrosedimentation rate with rheumatoid arthritis disease activity]. (19263661)
2008
10
Reiter's syndrome versus reactive arthritis: Nazi-phobia or professional concerns? (18548985)
2008
11
Clinical presentations of chlamydial and non-chlamydial reactive arthritis. (16432687)
2006
12
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
13
Successful treatment of postvenereal reactive arthritis with synovectomy and 3 months' azithromycin. (16357772)
2005
14
Reactive arthritis following BCG immunotherapy for bladder carcinoma. (15660288)
2005
15
The diagnostic utility of anti-cyclic citrullinated peptide antibodies, matrix metalloproteinase-3, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein in patients with erosive and non-erosive rheumatoid arthritis. (16295525)
2005
16
An elevated level of IL-10- and TGFbeta-secreting T cells, B cells and macrophages in the synovial membrane of patients with reactive arthritis compared to rheumatoid arthritis. (15459815)
2004
17
The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis. (15210773)
2004
18
Sporadic enteric reactive arthritis and undifferentiated spondyloarthropathy: evidence for involvement of Salmonella typhimurium. (12508398)
2003
19
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. (14687717)
2003
20
Reactive arthritis after BCG immunotherapy: T cell analysis in peripheral blood and synovial fluid. (12364630)
2002
21
Reactive arthritis after pharyngeal infection: report of two siblings. (24383909)
2002
22
Bacteria-Triggered reactive arthritis: implications for antibacterial treatment. (11293645)
2001
23
Sexually-acquired reactive arthritis. (11236622)
2001
24
Atypical sequelae of knee arthroscopy and reactive arthritis. (17984883)
2000
25
Report on the Fourth International Workshop on Reactive Arthritis. (10765916)
2000
26
Effect of a three month course of ciprofloxacin on the outcome of reactive arthritis. (10873968)
2000
27
Modulation of peripheral blood mononuclear cell activation status during Salmonella-triggered reactive arthritis. (10524675)
1999
28
A proposal for the classification of patients for clinical and experimental studies on reactive arthritis. (10381053)
1999
29
Salmonella-triggered reactive arthritis: use of polymerase chain reaction, immunocytochemical staining, and gas chromatography-mass spectrometry in the detection of bacterial components from synovial fluid. (9920018)
1999
30
Persistence of Yersinia antigens in peripheral blood cells from patients with Yersinia enterocolitica O:3 infection with or without reactive arthritis. (9588737)
1998
31
Clostridium difficile infection in patients with reactive arthritis of undetermined etiology. (9808399)
1998
32
Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter's syndrome are viable but show aberrant gene expression. (9558178)
1998
33
Characterization of serum antibody response to chlamydiae in patients with sexually acquired reactive arthritis. (9453389)
1997
34
Increase of HLA-DRB1*0408 and -DQB1*0301 in HLA-B27 positive reactive arthritis. (9059139)
1997
35
Is undifferentiated seronegative spondyloarthropathy a forme fruste of reactive arthritis? (9376974)
1997
36
Synovial membrane cytokine profiles in reactive arthritis secondary to intravesical bacillus Calmette-GuAcrin therapy. (9101513)
1997
37
Chlamydia trachomatis Can Persist in Joint Tissue After Antibiotic Treatment in Chronic Reiter's Syndrome / Reactive Arthritis. (19078167)
1997
38
Appendicitis followed by reactive arthritis in an HLA B27-positive man after infection with Yersinia enterocolitica, diagnosed by serotype specific antibodies and antibodies to Yersinia outer membrane proteins. (9334870)
1997
39
The pathogenesis of HLA-B 27-related reactive arthritis. (9041786)
1996
40
Reactive arthritis: characteristics in southern New Zealand. (8606843)
1996
41
Reactive arthritis by staphylococcus epidermidis: report of an unusual case. (8929778)
1996
42
Reactive arthritis, beta-haemolytic Streptococcus and Staphylococcus aureus. (8810681)
1996
43
Reactive arthritis. (8864585)
1996
44
Recent advances in the pathogenesis of reactive arthritis. (8871345)
1996
45
Reactive arthritis following Clostridium difficile colitis. (7863666)
1995
46
Antineutrophil cytoplasmic antibodies in reactive arthritis. (8835566)
1995
47
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. (7923879)
1994
48
The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. (1370300)
1992
49
Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. (1384103)
1992
50
A patient who developed reactive arthritis after an episode of salmonella enteritis was found to have a sterile urethritis. Is this a sympathetic reaction or should additional infection be suspected? (2012944)
1991

Genetic Variations for Reactive Arthritis

Expression for genes affiliated with Reactive Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for genes affiliated with Reactive Arthritis

Sources:
54Reactome, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Reactive Arthritis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ccl345 2911.4CCL16, CCL15, CCR1, CXCL5
2ccl445 2911.4IL17A, CXCL5, CCR1, CCL15
3glycosaminoglycan4510.4COMP, CCR1, MMP8
4rantes4510.4IL17A, CXCL5, CCR1, CCL14, CCL16
5p0024510.4MMP8, IL17A, COMP
6pge24510.3MMP8, IL17A, CXCL5, CCR1
7oligonucleotide4510.3COMP, S100A12, TRH, CXCL5, IL17A, MMP8
8zinc45 2411.2S100A12, OMP, CXCL5, MMP8, SLC11A1
9nitric oxide45 11 2412.1SLC11A1, MMP8, IL17A, CXCL5, CCR1
10calcium45 50 11 2413.0CCL15, CCL16, COMP, KLRB1, CCR1, S100A12
11hydrogen45 2410.9COMP, TRH, MMP8, SLC11A1

GO Terms for genes affiliated with Reactive Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CEACAM8, MMP8, IL17A, IL21, CXCL5, CCL15

Biological processes related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive chemotaxisGO:05091810.3CCL15, CCL16
2chemotaxisGO:00693510.3CCL16, CCL15, CCR1, CXCL5
3cell-cell signalingGO:00726710.2CCL16, CCL15, CCR1, TRH, CXCL5, IL17A
4cellular calcium ion homeostasisGO:00687410.2CCL14, CCL15, CCR1
5inflammatory responseGO:00695410.2SLC11A1, IL17A, S100A12, CCR1, CCL16
6immune responseGO:00695510.2CEACAM8, CCL16, CCL14, CCL15, CCR1, CXCL5
7positive regulation of osteoclast differentiationGO:04567210.1IL17A, CCR1

Molecular functions related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.3CCL15, CCL16
2chemokine activityGO:0080099.9CXCL5, CCL15, CCL14, CCL16

Products for genes affiliated with Reactive Arthritis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Reactive Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet