PIRA
MCID: RCT015
MIFTS: 63

Reactive Arthritis (PIRA) malady

Categories: Rare diseases, Bone diseases, Gastrointestinal diseases

Aliases & Classifications for Reactive Arthritis

Aliases & Descriptions for Reactive Arthritis:

Name: Reactive Arthritis 12 50 56 14
Reiter Syndrome 50 56 69
Arthritis, Reactive 42 69
Reiter Disease 12 56
Post-Infectious Reactive Arthropathy 50
Fiessinger Leroy Reiter Syndrome 12
Fiessinger-Leroy-Reiter Syndrome 56
Post-Dysenteric Arthropathy 69
Post-Bacterial Arthropathy 12
Postdysenteric Arthropathy 12
Post-Infectious Arthritis 50
Fiessinger-Leroy Disease 56
Polyarthritis Enterica 56
Arthritis Urethritica 56
Arthritis, Venereal 69
Venereal Arthritis 56
Arthritis Reactive 52
Reiter's Syndrome 50
Reiter's Disease 12
Reiters Syndrome 52
Pira 50

Characteristics:

Orphanet epidemiological data:

56
reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:6196
ICD9CM 35 099.3 711.3 711.30
MeSH 42 D016918
NCIt 47 C34975
Orphanet 56 ORPHA29207
MESH via Orphanet 43 D016918
UMLS via Orphanet 70 C0035012 C0085435
ICD10 via Orphanet 34 M02.3

Summaries for Reactive Arthritis

NIH Rare Diseases : 50 reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards based summary : Reactive Arthritis, also known as reiter syndrome, is related to uveitis and tuberculosis, and has symptoms including arthralgia, fever and photophobia. An important gene associated with Reactive Arthritis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methotrexate and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Disease Ontology : 12 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : 71 Reactive arthritis (Reiter\'s syndrome) is a form of inflammatory arthritis that develops in response to... more...

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
id Related Disease Score Top Affiliating Genes
1 uveitis 29.7 BPI CD79A TNF
2 tuberculosis 29.5 IL10 IL17A IL6 TNF
3 clostridium difficile colitis 29.2 CD79A IFNG IL6 TNF
4 bacterial meningitis 29.1 CRP HLA-B IL6 TNF
5 hepatitis 29.0 HLA-B IFNG IL10 IL6 TNF
6 rheumatoid arthritis 28.7 CD79A CRP HSPD1 IFNG IL10 IL17A
7 spondyloarthropathy 1 11.6
8 septic arthritis 11.5
9 shigellosis 11.2
10 arthritis 10.8
11 chlamydia 10.3
12 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
13 coloboma of iris 10.2 CRP IL6
14 dyslexia 5 10.2 IL6 TNF
15 aortic atherosclerosis 10.2 IL6 TNF
16 degenerative disc disease 10.2 IL6 TNF
17 aortic coarctation 10.2 HLA-B IL6 TNF
18 paragonimiasis 10.2 BPI IL17A IL6
19 mirizzi syndrome 10.2 HLA-B TNF
20 rickettsia parkeri spotted fever 10.2 HSPD1 IFNG
21 choanal atresia, bilateral 10.2 IL17A IL6 TNF
22 crohn's colitis 10.2 IL17A IL6 TNF
23 keratoconus 10.2 IL17A IL6 TNF
24 cutaneous sclerosis 10.2 CRP IL6
25 gastric lymphoma 10.1 CRP IL17A IL6
26 nguyen syndrome 10.1 IL10 IL17A
27 leukoplakia of vagina 10.1 IL6 MMP8 TNF
28 acute cholangitis 10.1 BPI HLA-B TNF
29 shoulder impingement syndrome 10.1 CRP IL6
30 premature menopause 10.1 CRP HSPD1 IL6
31 pyridoxal 5'-phosphate-dependent epilepsy 10.1 IL10 TNF
32 ureter inverted papilloma 10.1 IL10 IL6
33 tubular renal disease-cardiomyopathy syndrome 10.1 IL10 TNF
34 stocco dos santos syndrome 10.1 IFNG TNF
35 reproductive system disease 10.1 IL10 IL17A IL6
36 inhalation anthrax 10.1 CRP IL17A MMP8
37 unilateral multicystic dysplastic kidney 10.1 CRP IL6 TNF
38 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 HLA-B IFNG TNF
39 autosomal dominant deafness-onychodystrophy syndrome 10.1 IFNG TNF
40 esophagus lymphoma 10.1 IFNG IL6 TNF
41 human immunodeficiency virus infectious disease 10.1 CRP IL6 TNF
42 joint disorders 10.1 CRP IL6 TNF
43 cicatricial lagophthalmos 10.1 CRP IL6 TNF
44 fasciitis 10.1 BPI MMP8 TNF
45 benign neonatal seizures 10.1 CRP IL6 TNF
46 thymic neuroendocrine carcinoma 10.1 IL6 TNF
47 lagophthalmos 10.1 IL10 TNF
48 aniseikonia 10.1 IFNG IL17A TNF
49 neuropathy 10.1 CRP IL6 TNF
50 autoimmune disease of central nervous system 10.1 CRP IL6 TNF

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

56 32 (show all 26)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Very frequent (99-80%) HP:0002829
2 fever 56 32 Occasional (29-5%) HP:0001945
3 photophobia 56 32 Occasional (29-5%) HP:0000613
4 abdominal pain 56 32 Frequent (79-30%) HP:0002027
5 joint swelling 56 32 Very frequent (99-80%) HP:0001386
6 joint stiffness 56 32 Very frequent (99-80%) HP:0001387
7 diarrhea 56 32 Very frequent (99-80%) HP:0002014
8 respiratory insufficiency 56 32 Occasional (29-5%) HP:0002093
9 arthritis 56 32 Very frequent (99-80%) HP:0001369
10 cognitive impairment 56 32 Very frequent (99-80%) HP:0100543
11 pulmonary fibrosis 56 32 Occasional (29-5%) HP:0002206
12 hyperkeratosis 56 32 Very frequent (99-80%) HP:0000962
13 weight loss 56 32 Occasional (29-5%) HP:0001824
14 abnormality of the pleura 56 32 Frequent (79-30%) HP:0002103
15 inflammation of the large intestine 56 32 Frequent (79-30%) HP:0002037
16 osteomyelitis 56 32 Very frequent (99-80%) HP:0002754
17 pericarditis 56 32 Occasional (29-5%) HP:0001701
18 conjunctivitis 56 32 Very frequent (99-80%) HP:0000509
19 recurrent urinary tract infections 56 32 Occasional (29-5%) HP:0000010
20 cartilage destruction 56 32 Very frequent (99-80%) HP:0100773
21 dystrophic fingernails 56 32 Very frequent (99-80%) HP:0008391
22 aortic regurgitation 56 32 Occasional (29-5%) HP:0001659
23 recurrent aphthous stomatitis 56 32 Very frequent (99-80%) HP:0011107
24 pustule 56 32 Very frequent (99-80%) HP:0200039
25 enthesitis 56 32 Very frequent (99-80%) HP:0100686
26 abnormality of the nail 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Reactive Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 TRH CD79A CRP IFNG IL10 IL17A
2 neoplasm MP:0002006 9.63 CD79A IFNG IL10 IL6 MMP8 TNF
3 no phenotypic analysis MP:0003012 9.5 TRH CD79A IFNG IL10 IL17A OMP
4 respiratory system MP:0005388 9.1 IFNG IL10 IL17A IL6 OMP TNF

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 279)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
2
Sulfasalazine Approved Phase 4,Phase 3,Phase 1 599-79-1 5353980 5359476
3
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
4
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2 75706-12-6 3899
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
6
Colchicine Approved Phase 4,Phase 3,Phase 2 64-86-8 6167 2833
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
11
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Histamine Approved, Investigational Phase 4,Phase 1 75614-87-8, 51-45-6 774
14
Allopurinol Approved Phase 4 315-30-0 2094
15
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
16
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
17
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
18
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
19
Famotidine Approved Phase 4 76824-35-6 3325
20
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
21
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
22
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
23
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
24
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
25
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
26
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2 428863-50-7
27
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
28
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
29
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
31
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
32 beta-endorphin Phase 4
33 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
34 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
35 Adrenocorticotropic Hormone Phase 4
36 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
39 Hormones Phase 4,Phase 3,Phase 2,Phase 1
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
42 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Interleukin 1 Receptor Antagonist Protein Phase 4,Phase 2,Phase 3,Phase 1
44 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
45 Melanocyte-Stimulating Hormones Phase 4
46 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 vitamin d Phase 4
49
Corticosterone Phase 4 50-22-6 5753
50 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 498)
id Name Status NCT ID Phase
1 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4
2 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4
3 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4
4 Leflunomide in Rheumatoid Arthritis Completed NCT00280644 Phase 4
5 Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid Arthritis Completed NCT00356473 Phase 4
6 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4
7 Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial Completed NCT01400516 Phase 4
8 Acute Effect of Resistance Training in Inflammatory Markers in Women With Rheumatoid Arthritis Completed NCT02401958 Phase 4
9 Objective Study in Rheumatoid Arthritis Completed NCT00451971 Phase 4
10 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4
11 A Feasibility Study Exploring the Effect of Remicade on the Disease Activity in RA Patients (Study P05417) Completed NCT00741104 Phase 4
12 Study Looking at Longitudinal Changes in Fatigue and Health Status in Rheumatoid Arthritis (RA) Patients Treated With Subcutaneous Anti-TNF-α Therapy Completed NCT01521884 Phase 4
13 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker. Completed NCT00424502 Phase 4
14 A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs. Completed NCT01195272 Phase 4
15 Dosing Flexibility Study in Patients With Rheumatoid Arthritis Completed NCT00580840 Phase 4
16 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4
17 Efficacy and Safety Study of Tacrobell to Treat Rheumatoid Arthritis Completed NCT01746680 Phase 4
18 A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs. Completed NCT00996203 Phase 4
19 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4
20 A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDS Completed NCT01149057 Phase 4
21 Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel) Completed NCT01313208 Phase 4
22 A Study of Tocilizumab With or Without Methotrexate in Patients With Rheumatoid Arthritis. Completed NCT01010503 Phase 4
23 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4
24 Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening Completed NCT01578850 Phase 4
25 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed NCT00141102 Phase 4
26 A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies. Completed NCT00462345 Phase 4
27 An Efficacy and Safety Study of Infliximab in Participants With Rheumatoid Arthritis Completed NCT00896168 Phase 4
28 A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01089023 Phase 4
29 Open-label Safety and Pharmacokinetic Study of DUEXIS® (Ibuprofen and Famotidine) Tablets in Juvenile Idiopathic Arthritis Completed NCT01563185 Phase 4
30 Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients Completed NCT00650455 Phase 4
31 Drug Concentration, Immunogenicity, and Efficacy Study in Patients With Rheumatoid Arthritis Currently Treated With Etanercept, Adalimumab, or Infliximab Completed NCT01981473 Phase 4
32 Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA Completed NCT00858780 Phase 4
33 A Study of Infliximab for Treatment Resistant Major Depression Completed NCT00463580 Phase 4
34 A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With RA Having Completed the Studies ML21530 And MA21488 Completed NCT01715831 Phase 4
35 Efficacy and Safety of Lumiracoxib 400 mg Once Daily in Acute Flares of Gout Completed NCT00170781 Phase 4
36 Initiation of Allopurinol at First Medical Contact for Acute Attacks of Gout Completed NCT01310673 Phase 4
37 Study to Assess the Efficacy and Safety of Reflex Plus™ in Osteoarthritis Completed NCT02655939 Phase 4
38 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4
39 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4
40 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4
41 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4
42 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
43 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
44 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Recruiting NCT02837978 Phase 4
45 Direct Anterior Approach Versus Direct Lateral Approach in Total Hip Arthroplasty Recruiting NCT02719236 Phase 4
46 Zushima Plaster for Treating Knee Osteoarthritis Recruiting NCT02770950 Phase 4
47 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Recruiting NCT02509026 Phase 4
48 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Recruiting NCT02897115 Phase 4
49 A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis Not yet recruiting NCT03151551 Phase 4
50 Pre-operative Intravenous Steroid in Total Knee Replacement for Pain Relief and Recovery Not yet recruiting NCT03082092 Phase 4

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

39
Eye, T Cells, Bone, B Cells, Neutrophil, Heart, Tonsil

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 571)
id Title Authors Year
1
Epidemiology: Time to revisit the concept of reactive arthritis. ( 28490789 )
2017
2
IL-17 and IFN-I^ producing NK and I^I'-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis. ( 28390966 )
2017
3
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
4
Reactive Arthritis Caused by Yersinia enterocolitica Enteritis. ( 28502944 )
2017
5
A bicentre retrospective study of features and outcomes of patients with reactive arthritis. ( 28238883 )
2017
6
Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis. ( 28496443 )
2017
7
Reactive Arthritis. ( 28292540 )
2017
8
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
9
Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )
2016
10
Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )
2016
11
Evolution over thirty years of the profile of inpatients with reactive arthritis in a tertiary rheumatology unit. ( 27600249 )
2016
12
Trafficking of antigens from gut to sacroiliac joints and spine in reactive arthritis and spondyloarthropathies: Mainly through lymphatics? ( 26968111 )
2016
13
Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )
2016
14
Epidemiology of Clostridium difficile Infection-Associated Reactive Arthritis in Children: An Underdiagnosed, Potentially Morbid Condition. ( 27182697 )
2016
15
Clostridium difficile associated reactive arthritis: Case report and literature review. ( 26743187 )
2016
16
Anti-TNF treatment of reactive arthritis. A monocentric experience. ( 27236263 )
2016
17
Early treatment of reactive arthritis with etanercept and 2 years follow-up. ( 27269651 )
2016
18
A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman. ( 27513386 )
2016
19
The incidence of sexually acquired reactive arthritis: a systematic literature review. ( 27480977 )
2016
20
Recombinant Salmonella typhimurium Outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce IL17/IL23 in patients with Reactive arthritis and undifferentiated spondyloarthropathy. ( 27060348 )
2016
21
Reactive Arthritis Caused by Urinary Tract Infection. ( 27150879 )
2016
22
Reactive arthritis following a Microsporidia infection. ( 27020082 )
2016
23
Microbe-triggered arthropathies: reactive arthritis and beyond. ( 27232885 )
2016
24
Sexually acquired reactive arthritis. ( 27037393 )
2016
25
Clostridium difficile Enterocolitis and Reactive Arthritis: A Case Report and Review of the Literature. ( 27190666 )
2016
26
European guideline for managing sexually acquired reactive arthritis. ( 26647401 )
2016
27
Association between Giardia and arthritis or joint pain in a large health insurance cohort: could it be reactive arthritis? ( 27640995 )
2016
28
Post-streptococcal reactive arthritis: where are we now. ( 27520996 )
2016
29
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
30
THE SOURCE OF INFECTION AND THE MOST FREQUENT CAUSES OF REACTIVE ARTHRITIS IN KOSOVO. ( 27482162 )
2016
31
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016
32
Reactive arthritis in relation to internal derangements of the temporomandibular joint: a case control study. ( 25957137 )
2015
33
High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice. ( 25624153 )
2015
34
Do IgA antibodies to Chlamydia trachomatis have protective role in humoral immunity: a study in reactive arthritis patients. ( 26482506 )
2015
35
Circinate balanitis as the presenting symptom of sexually-acquired reactive arthritis: a case report. ( 25918330 )
2015
36
Modes of presentation of reactive arthritis based on the affected joints. ( 25870477 )
2015
37
Grisel syndrome, acute otitis media, and temporo-mandibular reactive arthritis: A rare association. ( 26060148 )
2015
38
Reactive arthritis at the Sydney Sexual Health Centre 1992-2012: declining despite increasing chlamydia diagnoses. ( 26378192 )
2015
39
Late cardiac assessment in children diagnosed with post-streptococcal reactive arthritis: a long term study. ( 26203934 )
2015
40
Concurrent peritonsillar abscess and poststreptococcal reactive arthritis complicating acute streptococcal tonsillitis in a young healthy adult: a case report. ( 25885601 )
2015
41
Three cases of reactive arthritis secondary to lymphogranuloma venereum. ( 25539432 )
2015
42
Reactive arthritis in ancient Egypt: a possible description in medical papyri. ( 24585524 )
2014
43
2014 European Guideline on the management of sexually acquired reactive arthritis. ( 24974322 )
2014
44
Reactive arthritis mimicking inflammatory bowel disease arthritis: a challenging diagnosis. ( 25111419 )
2014
45
Diagnosis and classification of reactive arthritis. ( 24418301 )
2014
46
Concurrent occurrence of juvenile reactive arthritis and IgA nephropathy. ( 24424089 )
2014
47
Diagnosis of Chlamydia trachomatis in patients with reactive arthritis and undifferentiated spondyloarthropathy. ( 24820470 )
2014
48
Folate-functionalized dendrimers for targeting Chlamydia-infected tissues in a mouse model of reactive arthritis. ( 24607214 )
2014
49
Reactive arthritis induced by intravesical BCG therapy for bladder cancer. ( 24510697 )
2014
50
Observations on Chlamydia trachomatis and other microbes in reactive arthritis. ( 24828551 )
2014

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 BPI CD79A CRP HLA-B IFNG IL10
2
Show member pathways
13.26 HLA-B IFNG IL10 IL17A IL6 TNF
3
Show member pathways
12.65 HLA-B HSPD1 IFNG IL10 IL17A IL6
4
Show member pathways
12.53 CD79A IFNG IL10 TNF
5
Show member pathways
12.52 IFNG IL10 IL17A IL6 TNF
6
Show member pathways
12.51 IFNG IL10 IL17A IL6 TNF
7 12.46 CD79A IFNG IL10 IL17A TNF
8
Show member pathways
12.35 IFNG IL10 IL17A IL6 TNF
9
Show member pathways
12.28 CRP IFNG IL6 TNF
10
Show member pathways
12.28 IFNG IL17A IL6 TNF
11 12.12 HSPD1 IL10 IL6 TNF
12 12.11 HSPD1 IFNG IL10 IL6 TNF
13 11.93 IFNG IL6 TNF
14 11.92 IL10 IL17A IL6 TNF
15 11.87 CD79A IFNG IL10 IL6 TNF
16
Show member pathways
11.85 IFNG IL17A IL6
17 11.83 IFNG IL10 IL6 TNF
18 11.78 IFNG IL17A IL6 TNF
19 11.72 IL10 IL6 TNF
20 11.7 IFNG IL10 IL17A TNF
21 11.68 IL10 IL6 TNF
22
Show member pathways
11.68 IFNG IL10 IL17A IL6 TNF
23 11.66 IFNG IL10 IL6
24 11.66 IFNG IL10 IL6 TNF
25
Show member pathways
11.63 IFNG IL6 TNF
26 11.55 HSPD1 IL6 TNF
27 11.51 IFNG IL6 TNF
28 11.48 IL10 IL6 TNF
29 11.44 IFNG IL6 TNF
30 11.42 IFNG IL10 IL6 TNF
31
Show member pathways
11.38 IFNG IL10 TNF
32 11.31 IL10 IL6 TNF
33
Show member pathways
11.31 HLA-B IFNG IL10 IL17A IL6 TNF
34 11.17 IFNG IL10 IL6 TNF
35 11.15 IL10 IL17A IL6 TNF
36 10.97 CRP IL6 TNF
37 10.96 IFNG IL17A IL6 TNF
38 10.73 IFNG IL10 IL6 TNF

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 BPI CRP IFNG IL10 IL17A IL6
2 external side of plasma membrane GO:0009897 9.35 CD79A IFNG IL17A IL6 TNF
3 extracellular space GO:0005615 9.28 BPI CRP HSPD1 IFNG IL10 IL17A

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 CRP IFNG IL6 TNF
2 positive regulation of apoptotic process GO:0043065 9.96 HSPD1 IFNG IL6 TNF
3 response to drug GO:0042493 9.95 HSPD1 IFNG IL10 IL6
4 inflammatory response GO:0006954 9.93 CRP IL10 IL17A IL6 TNF
5 defense response to bacterium GO:0042742 9.89 BPI IFNG IL10 TNF
6 response to organic cyclic compound GO:0014070 9.86 HSPD1 IL6 TRH
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.83 IL10 IL6 TNF
8 response to organic substance GO:0010033 9.81 HSPD1 IL10 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
10 humoral immune response GO:0006959 9.76 IFNG IL6 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.74 HSPD1 IL6 TNF
12 response to cold GO:0009409 9.73 HSPD1 IL6 TRH
13 cellular response to lipopolysaccharide GO:0071222 9.73 IFNG IL10 IL6 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 IFNG IL6 TNF
15 positive regulation of interleukin-6 secretion GO:2000778 9.68 HSPD1 IL17A
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.68 IL10 TNF
17 positive regulation of chemokine production GO:0032722 9.68 IL6 TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IFNG TNF
19 cellular response to hepatocyte growth factor stimulus GO:0035729 9.67 IL10 IL6
20 positive regulation of macrophage activation GO:0043032 9.65 HSPD1 IL10
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 TNF
22 B cell proliferation GO:0042100 9.65 CD79A HSPD1 IL10
23 positive regulation of protein import into nucleus, translocation GO:0033160 9.64 IFNG IL6
24 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IFNG TNF
25 endothelial cell apoptotic process GO:0072577 9.63 IL10 TNF
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IFNG IL10
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
29 negative regulation of interleukin-8 production GO:0032717 9.6 BPI IL10
30 positive regulation of interleukin-23 production GO:0032747 9.58 IFNG IL17A
31 negative regulation of interleukin-6 production GO:0032715 9.58 BPI IL10 TNF
32 positive regulation of osteoclast differentiation GO:0045672 9.54 IFNG IL17A TNF
33 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
34 neutrophil apoptotic process GO:0001781 9.51 IFNG IL6
35 defense response to protozoan GO:0042832 9.5 IFNG IL10 IL6
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG TNF
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 IFNG TNF
38 response to glucocorticoid GO:0051384 9.46 HSPD1 IL10 IL6 TNF
39 negative regulation of growth of symbiont in host GO:0044130 9.43 IFNG IL10 TNF
40 immune response GO:0006955 9.17 BPI HLA-B IFNG IL10 IL17A IL6
41 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL17A IL6 TNF

Sources for Reactive Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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