Reactive Arthritis malady

NIH Rare Diseases: Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain. ³⁰

MalaCards: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and juvenile rheumatoid arthritis. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs meclofenamate sodium and devils claw and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include nk cells, t cells and b cells, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Disease Ontology: An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.⁶

Wikipedia: Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in...⁴⁴ more...

Aliases & Descriptions:

reactive arthritis 6 30 8 reiter syndrome 30 43 post-infectious reactive arthropathy 30 fiessinger leroy reiter syndrome 6 post-dysenteric arthropathy 43 postdysenteric arthropathy 6 post-bacterial arthropathy 6 post-infectious arthritis 30

arthritis, reactive 43 arthritis reactive 32 reiter's syndrome 30 reiter's disease 6 reiters syndrome 32 reiter disease 6 arthritis 43 pira 30

Diseases related to reactive arthritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 916)

id	Related Disease	Score	Top Affiliating Genes
1	arthritis	33.4	IL17A, IL1B, IL6, IL8, TNF, TNFRSF1A
2	juvenile rheumatoid arthritis	33.2	IL18R1, IL2RA, IL6, HSPD1, HLA-DRB1, TRB@
3	rheumatoid arthritis	30.7	IL10, IL1B, IL2, IL21, HLA-DRB1, TNF
4	hepatitis	30.4	IFNB1, HLA-DRB1, TNFRSF1A, CR1, LTF, TAP2
5	adult-onset still's disease	30.1	IL18, IL6, CRP
6	aggressive periodontitis	30.1	MMP1, MMP8, HLA-B, LTF
7	septic arthritis	30.0	IL1B, IFNG, TNF, CRP, TLR2, TLR4
8	connective tissue disease	29.3	BMP6, CD36, HSPD1, TRB@, LTF
9	ankylosing spondylitis	29.2	CD79A, IL17A, HSPD1, HLA-B, TNF, TNFRSF1A
10	rheumatoid arthritis, association with	29.1	SELE, CD79A, IL10, IL18, IL1B, IL6
11	blau syndrome	28.9	IL10, IL1B, TNF
12	multiple sclerosis	28.7	IL1B, IL2RA, CCR5, IFNG, HLA-B, HLA-DRB1
13	primary biliary cirrhosis	28.1	CD79A, HSPD1, HLA-B, HLA-DRB1, LTF, PRTN3
14	psoriatic arthritis	28.1	IL10, IL1B, IL6, TNF
15	osteonecrosis	28.0	BMP6, CD36, IL17A, TP53, COMP
16	spondylarthropathy	27.9	TNF, CRP, TLR4
17	tuberculosis	27.7	IL10, IL1B, IFNG, TNF, CR1, TLR4
18	castleman's disease	27.5	IL10, IL6, TP53, CR1, CRP
19	visceral leishmaniasis	27.4	IL10, IFNG, SLC11A1
20	palindromic rheumatism	27.4	IL1B, HLA-DRB1, TNF, TNFRSF1A
21	vascular disease	27.3	SELE, BSG, BMP6, ITGAM, HSPD1, CRP
22	hyperprolactinemia	27.3	SELE, IL6, IFNG, TRH, TP53, PRTN3
23	coccidioidomycosis	27.1	IL10, IFNG, TLR4
24	joint disorders	27.0	IL18R1, IL6, TNF, TIMP1
25	gout	26.9	SELE, CD79A, IL1B, IL2RA, IL6, IL8
26	acquired immunodeficiency syndrome	26.9	ITGAM, IL18R1, IL2, CCR5, CCR1, HLA-B
27	back pain	26.6	CD36, IL1B, IL6, TNF
28	amyloidosis	26.5	CD79A, IL1B, IL6, ANPEP, IFNG, HLA-B
29	polymyalgia rheumatica	26.5	IL1B, IL2, IL2RA, IL6, CCR5, IFNG
30	crohn's disease	26.4	BPI, IL10, IL17A, IL18, IL1B, IL6
31	scleritis	26.3	IFNG, HLA-B, TNF, TIMP1, PRTN3
32	invasive aspergillosis	26.1	TLR2, TLR4
33	hypoglycemia	26.1	CD79A, CD36, IL1B, IL6, TRH, TNF
34	periodontitis	26.0	BSG, CD36, MMP1, MMP8, IL10, IL17A
35	osteoporosis	26.0	SELE, BMP6, CD79A, CD36, MMP8, IL10
36	schizophrenia	25.7	BMP6, IL1B, IL2, CCR5, TNF
37	hemochromatosis	25.7	BMP6, IL6, HLA-B, HLA-DRB1, TP53, TNF
38	lymphopenia	25.7	IL10, IL18, IL2, IL2RA, IL6, IFNG
39	rosacea	25.6	MMP8, IL18, IL8, TLR2
40	kaposi's sarcoma	25.6	SELE, IL6, IFNB1, CXCL10
41	pulmonary tuberculosis	25.5	IL10, IL18, IL2, IL2RA, IFNG, HLA-DRB1
42	pyoderma gangrenosum	25.4	MMP1, IL6, IL8, TNF, PRTN3
43	pyoderma	25.4	MMP1, IL6, IL8, TNF, PRTN3
44	mixed connective tissue disease	25.3	IL6, HSPD1, HLA-DRB1, TRB@, TNF, CRP
45	systemic scleroderma	25.2	SELE, MMP1, IL6, IFNG, CRP
46	rheumatoid vasculitis	25.2	SELE, HLA-DRB1, TNF, LTF
47	hepatitis b	25.2	IL10, IL17A, IL18, IL2RA, CCR5, IFNG
48	sapho syndrome	25.0	HLA-B, TP53, TNF
49	ischemic heart disease	25.0	SELE, CD79A, MMP1, IL1B, IL6, IL8
50	carpal tunnel syndrome	25.0	CD36, IL1B, IL2, IL6

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 devils claw, meclofenamate, meclofenamate sodium, salsalate

MalaCards organs/tissues related to reactive arthritis:

²²

MGI Mouse Phenotypes related to reactive arthritis:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	SLC11A1, IL17A, IL21, CCR1, TRB@, TAP1
2	renal/urinary system phenotype	MP:0005367	9.6	SOD2, CXCR4, CCR1
3	digestive/alimentary phenotype	MP:0005381	8.7	TRB@, TLR2, CXCR4, SLC11A1, IFNG, CCR1
4	nervous system phenotype	MP:0003631	8.7	TLR4, TAP1, OMP, CXCL10, CXCR4, ROM1
5	skeleton phenotype	MP:0005390	8.6	CXCR4, COMP, TNFRSF1A, TP53, IFNB1, IL6
6	adipose tissue phenotype	MP:0005375	8.0	TLR4, TLR2, TNFRSF1A, TNF, TP53, IL6
7	liver/biliary system phenotype	MP:0005370	7.9	TRB@, TP53, TLR2, TLR4, IFNG, CCR1
8	growth/size phenotype	MP:0005378	7.5	TRH, TRB@, TP53, COMP, PHB2, TLR4
9	reproductive system phenotype	MP:0005389	7.4	TNFRSF1A, PHB2, TLR4, TIMP1, SOD2, TNF
10	muscle phenotype	MP:0005369	7.3	TNFRSF1A, COMP, TLR2, CXCR4, SOD2, TNF
11	homeostasis/metabolism phenotype	MP:0005376	7.1	TNFRSF1A, CYP1A1, CRP, LTF, TLR2, TLR4
12	vision/eye phenotype	MP:0005391	6.9	TP53, TNF, TNFRSF1A, TLR4, SOD2, ROM1
13	mortality/aging	MP:0010768	6.6	HSPD1, TRB@, TP53, TNFRSF1A, PHB2, TLR2
14	immune system phenotype	MP:0005387	6.3	LTF, TLR4, PRTN3, CXCL10, SOD2, SLC11A1
15	tumorigenesis	MP:0002006	6.0	TNF, TNFRSF1A, TLR2, TLR4, TIMP1, TAP1
16	cardiovascular system phenotype	MP:0005385	4.8	TNF, TNFRSF1A, CYP1A1, CRP, TLR2, TLR4
17	cellular phenotype	MP:0005384	4.8	TNFRSF1A, TNF, TP53, TRB@, HSPA1B, PHB2

Articles related to reactive arthritis:

(show top 50)    (show all 56)

id	Title	Authors	Year	Affiliating Genes
1	Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy. (21181220)	Singh A.K.... Aggarwal A.	2011	IL6, IL1B, IL17A
2	Prevalence of antibodies against Chlamydia trachomati s and incidence of C. trachomatis-induced reactive arthritis in an early arthri tis series in Finland in 2000. (19296404)	Savolainen E.... Kaipiainen-SeppAonen O.	2009	CD79A
3	Detection and frequency of Chlamydia trachomatis DNA in synovial samples from Tunisian patients with reactive arthritis and undifferentiated oligoarthritis. (19159429)	Siala M.... Hammami A.	2009	ROM1
4	Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis in Tunisia. (19152094)	Siala M.... Makni H.	2009	HLA-B
5	Identification of candidate genes for susceptibility to reactive arthritis. (19506876)	Rihl M.... Kuipers J.G.	2009	IL8, CXCL10, CXCL5
6	Relationship between gamma-interferon and interleukin -17 in Chlamydia trachomatis reactive arthritis. (19917178)	Bas S.... Gabay C.	2009	IFNG, IL17A
7	Toll-like receptor 2 variants are associated with acute reactive arthritis. (18975326)	Tsui F.W.... Inman R.D.	2008	TLR2, TLR4
8	Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. (17376200)	Singh R.... Misra R.	2007	OMP
9	Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis. (17211726)	Chen Y.J.... Yen J.H.	2007	SLC11A1
10	Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. (17937463)	Singh R.... Misra R.	2007	IL6, IFNG, BMP6
11	Study of predominant bacterial antigens triggering antibody response in Salmonella reactive arthritis: apropos of a case. (17642539)	Lacoste M.G.... Di Genaro M.S.	2007	OMP
12	Clinical presentations of chlamydial and non-chlamydial reactive arthritis. (16432687)	OzgA1l A.... Kalyon T.A.	2006	CRP
13	Identification of immunodominant CD4+ T cell epitopes in patients with Yersinia-induced reactive arthritis by cytometric cytokine secretion assay. (17075864)	Thiel A.... Sieper J.	2006	HSPD1
14	Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. (16107514)	Haringman J.J.... Tak P.P.	2006	CXCR4, ANPEP, CCR5
15	Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)	van Holten J.... Tak P.P.	2005	IFNB1
16	Cellular and humoral markers of systemic inflammation in acute reactive arthritis and early rheumatoid arthritis. (15124937)	Kuuliala A.... Repo H.	2004	SELE, ITGAM
17	Lack of association between the HLA-DRB1 locus and post-streptococcal reactive arthritis and acute rheumatic fever in Italian children. (15505772)	Simonini G.... Falcini F.	2004	HLA-DRB1
18	Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and SjAPgren's syndrome. (15059267)	Skoumal M.... Dunky A.	2004	COMP
19	Management of reactive arthritis. (14680436)	Palazzi C.... Petricca A.	2004	TNF
20	Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. (12626797)	Bas S.... Gabay C.	2003	IL18, IFNG
21	Increased type I collagen degradation correlates with disease activity in reactive arthritis. (12673897)	Kotaniemi A.... Hakala M.	2003	CD36
22	Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. (11920401)	Straub R.H.... Leirisalo-Repo M.	2002	IL6
23	Importance of species-specific antigens in the serodiagnosis of Chlamydia trachomatis reactive arthritis. (12209035)	Bas S.... Vischer T.L.	2002	CD79A
24	Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis. (11978777)	Dulphy N.... Toubert A.	2002	KLRB1
25	Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. (12472659)	May E.... Marker-Hermann E.	2002	HLA-B, TRB@
26	Influence of infection of cells with bacteria associated with reactive arthritis on the peptide repertoire presented by HLA-B27. (11289525)	Ringrose J.H.... Feltkamp T.E.	2001	RPS17
27	IL10.G microsatellites mark promoter haplotypes associated with protection against the development of reactive arthritis in Finnish patients. (11352256)	Kaluza W.... Hohler T.	2001	IL10
28	Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. (10640771)	Mertz A.K.... Sieper J.	2000	HSPD1
29	BPI-ANCA is found in reactive arthritis caused by Yersinia and Salmonella infection and recognise exclusively the C-terminal part of the BPI molecule. (11028843)	Schultz H.... Gross W.L.	2000	BPI
30	p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. (10323450)	Tak P.P.... Firestein G.S.	1999	TP53
31	Helicobacter pylori--a trigger of reactive arthritis? (10885836)	Melby K.K.... GlennAYs A.	1999	CRP
32	Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter's syndrome are viable but show aberrant gene expression. (9558178)	GAcrard H.C.... Hudson A.P.	1998	HSPD1
33	Synovial membrane cytokine profiles in reactive arthritis secondary to intravesical bacillus Calmette-GuAcrin therapy. (9101513)	Smith M.D.... Roberts-Thomson P.	1997	TNF, IL8
34	Antigen-dependent B cell differentiation in the synov ial tissue of a patient with reactive arthritis. (9131588)	SchrAPder A.E.... Berek C.	1997	HLA-B
35	Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine (8763085)	Eulry F.... Claude-Berthelot C.	1996	TRH
36	Soluble receptors for tumor necrosis factor and interleukin-2 in serum and synovial fluid of patients with rheumatoid arthritis, reactive arthritis and osteoarthritis. (7783054)	Steiner G.... Smolen J.	1995	IL2RA, IL2, TNFRSF1A
37	TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. (8770637)	Westman P.... Koskimies S.	1995	TAP1, TAP2
38	Reactive arthritis: a favorable 2 year course and outcome, independent of triggering agent and HLA-B27. (7699628)	GlennAYs A.... Thoen J.E.	1994	CRP
39	Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. (8192476)	Lauhio A.... Sorsa T.	1994	MMP8
40	In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. (7923879)	Lauhio A.... Sorsa T.	1994	MMP8, MMP1, LTF
41	HSP70-Hom NcoI polymorphism and HLA-associations in the Finnish population and in patients with ankylosing spondylitis or reactive arthritis. (9098422)	Westman P.... Koskimies S.	1994	HSPA1B
42	Relative hyperprolactinemia under protirelin in reactive arthritis. Preliminary results (7971809)	Eulry F.... Magnin J.	1994	TRH
43	Prolactin response to protirelin in reactive arthritis and ankylosing spondyloarthritis. Failure of treatment of 4 reactive arthritis with bromocriptine (7858584)	Eulry F.... Lechevalier D.	1994	TRH
44	Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis. (7678742)	Saxne T.... HeinegAYrd D.	1993	COMP
45	IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis. (1316199)	MAoki-Ikola O.... Granfors K.	1992	CD79A
46	Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. (1384103)	MetsAorinne K.P.... Fyhrquist F.Y.	1992	IL6, CRP
47	Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis? (1531747)	Lahesmaa R.... Toivanen A.	1992	CR1
48	Cationic Yersinia antigen-induced chronic allergic ar thritis in rats. A model for reactive arthritis in humans. (1864972)	Mertz A.K.... Gondolf K.B.	1991	CNBP
49	Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. (1918267)	Felzmann T.... Knapp W.	1991	BSG, CR1, CEACAM8
50	Salmonella-specific antibodies in reactive arthritis. (1955713)	MAoki-Ikola O.... Granfors K.	1991	CD79A

Genes related to reactive arthritis according to GeneCards:

(show top 50)    (show all 64)

id	Symbol	Description	Score	GeneCards Section Context
1	OMP	olfactory marker protein	11.0	Publications
2	RPS17	ribosomal protein S17	11.0	Publications
3	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	11.0	Publications
4	CCL16	chemokine (C-C motif) ligand 16	11.0	Publications
5	CCL15	chemokine (C-C motif) ligand 15	11.0	Publications
6	CCL14	chemokine (C-C motif) ligand 14	11.0	Publications
7	ROM1	retinal outer segment membrane protein 1	11.0	Publications
8	MRAP	melanocortin 2 receptor accessory protein	11.0
9	COMP	cartilage oligomeric matrix protein	11.0	Publications
10	S100A12	S100 calcium binding protein A12	11.0	Publications
11	OR2Y1	olfactory receptor, family 2, subfamily Y, member 1	11.0
12	TRH	thyrotropin-releasing hormone	11.0	Publications
13	MARVELD2	MARVEL domain containing 2	11.0
14	KLRB1	killer cell lectin-like receptor subfamily B, member 1	11.0	Publications
15	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
16	CNBP	CCHC-type zinc finger, nucleic acid binding protein	11.0	Publications
17	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
18	MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	11.0	Publications
19	IL21	interleukin 21	11.0	Publications
20	IL17A	interleukin 17A	11.0	Publications
21	PHB2	prohibitin 2	11.0
22	CCR1	chemokine (C-C motif) receptor 1	11.0	Publications
23	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
24	BPI	bactericidal/permeability-increasing protein	11.0	Publications
25	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
26	PRTN3	proteinase 3	11.0	Publications
27	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications
28	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
29	LTF	lactotransferrin	11.0	Publications
30	IL18R1	interleukin 18 receptor 1	11.0	Publications
31	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
32	BSG	basigin (Ok blood group)	11.0	Publications
33	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
34	HSPA1B	heat shock 70kDa protein 1B	11.0	Publications
35	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
36	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
37	BMP6	bone morphogenetic protein 6	11.0	Publications
38	SELE	selectin E	11.0	Publications
39	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
40	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
41	TRB@	T cell receptor beta locus	11.0	Publications
42	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
43	CRP	C-reactive protein, pentraxin-related	11.0	Publications
44	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
45	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
46	TLR2	toll-like receptor 2	11.0	Publications
47	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
48	TLR4	toll-like receptor 4	11.0	Publications
49	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
50	IFNB1	interferon, beta 1, fibroblast	11.0	Publications

Pathways related to reactive arthritis according to GeneDecks:

(show top 50)    (show all 102)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.3	TLR2
2	RAR-Gamma-RXR-Alpha Degradation36	10.1	CXCL5, CCL14, CCL16, CCL15, IL21, IL2
3	NFAT Signaling and Lymphocyte Interactions36	10.1	CCL16, BMP6, IL2, CCL15, CCL14
4	Graft-versus-host disease20	10.0	IL2, HLA-B
5	Regulation of eIF4 and p70S6K36	9.3	CCL14, IL2, IL18, IL6, ITGAM, CCL16
6	IL-6 Pathway36	8.8	CXCL5, CXCL10, CCL16, TIMP1, CCL14, CCL15
7	Molecular Mechanisms of Cancer36	8.8	TIMP1, TP53, CCL14, CCR1, CCL16, CCL15
8	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	IL17A, IL1B, IL6, IFNG, TLR2, TLR4
9	Phagosome20	8.7	HLA-B, HLA-DRB1, COMP, TLR2, TLR4, TAP2
10	PGC1Alpha Pathway36	8.6	CCL14, CCL16, TNFRSF1A, CCL15, IL8, BMP6
11	MSP-RON Signaling36	8.5	TLR4, TLR2, TNF, IFNG, IL18, ITGAM
12	Amoebiasis20	8.5	IL1B, IL8, TLR2, TLR4, IL6, ITGAM
13	Endothelin-1 Signaling Pathway36	8.4	IL18, IL21, CXCL5, CXCL10, CCL14, CCL16
14	Th1 Differentiation37	8.3	IL10, IL18, IL18R1, IL2, TNF, TLR2
15	African trypanosomiasis20	8.2	SELE, IL10, IL18, IL1B, IL6, IFNG
16	Hematopoietic cell lineage20	8.1	IL1B, CD36, ITGAM, CR1, TNF, HLA-DRB1
17	ERK Signaling36	8.1	CXCL5, IL6, IL2, CCL16, BMP6, IL18
18	Leishmaniasis20	7.9	IL10, TLR2, TLR4, IL1B, CR1, IFNG
19	Type I diabetes mellitus20	7.9	TNF, IL2, IFNG, HLA-DRB1, IL1B, HLA-B
20	Pertussis20	7.8	CXCL5, ITGAM, IL10, IL1B, IL6, TLR4
21	Toxoplasmosis20	7.8	TLR2, CCR5, IFNG, HSPA1B, HLA-DRB1, TNF
22	THC Differentiation Pathway36	7.8	IL2RA, HLA-DRB1, IFNG, IL10, IL2, IL18R1
23	Rho Family GTPases36	7.8	BMP6, CXCL5, ITGAM, IL18, CCL14, CCL16
24	SOCS Pathway36	7.7	CCL14, CCL15, IL8, IL6, IL2, IL1B
25	Measles20	7.6	IL1B, IL2, IL2RA, IL6, IFNB1, TLR2
26	Immune response MIF in innate immunity response10	7.5	IL1B, IFNG, TP53, TNF, TLR4, IL8
27	Immune response_MIF in innate immunity response41	7.5	TP53, TNF, IL1B, IL8, IL6, IFNG
28	Immune response_MIF-mediated glucocorticoid regulation41	7.4	IL8, TNF, IFNG, IL6, IL2, MMP1
29	Akt Signaling36	7.4	IL18R1, IL18, IL10, ITGAM, IL2, IL21
30	Glucocorticoid Receptor Signaling36	7.2	IL2RA, IL10, IL18, IL18R1, TNFRSF1A, HSPA1B
31	Immune response MIF-mediated glucocorticoid regulation10	7.2	MMP1, IL2, IL6, IL8, IFNG, TNF
32	all-trans-Retinoic Acid Signaling in Brain36	7.2	IL1B, IL18, IL10, BMP6, CXCL5, IL21
33	TGF-Beta Pathway36	7.2	CCL15, IL18, IL18R1, IL1B, IL2, IL2RA
34	MIF Mediated Glucocorticoid Regulation36	7.0	CXCL5, CXCL10, TLR4, TNF, CCL14, CCL16
35	PEDF Induced Signaling36	7.0	IL6, IL21, IL2, IL1B, IL18, IL10
36	Cytokine Network36	7.0	IFNB1, IL10, IL6, IL2, IL1B, IL18
37	PAK Pathway36	6.8	IL10, CCL16, IL18, TNF, TIMP1, CXCL10
38	MAPK Family Pathway36	6.7	CCL15, BMP6, TNFRSF1A, TNF, CCL14, IL8
39	Tuberculosis20	6.7	ITGAM, IL10, TLR4, IL18, IL1B, IL6
40	Malaria20	6.7	CD36, IL10, IL18, IL1B, IL6, IL8
41	Chagas disease (American trypanosomiasis)20	6.7	TNFRSF1A, TLR4, TLR2, IL6, IL10, IL1B
42	Tec Kinases Signaling36	6.7	TLR4, TIMP1, CXCR4, TLR2, BMP6, IL2
43	MIF Regulation of Innate Immune Cells36	6.6	BMP6, IL10, IL18, CXCL5, CXCL10, TLR4
44	Rheumatoid arthritis20	6.6	MMP1, IL17A, IL18, IL1B, IL6, IL8
45	Influenza A20	6.5	IL18, CXCL10, TLR4, TNFRSF1A, TNF, HLA-DRB1
46	JAK-STAT Pathway36	6.2	BMP6, IL2RA, IL8, CCL15, CCL16, CCL14
47	STAT3 Pathway36	6.1	IL2RA, IL21, IL2, IL1B, IL18R1, IL18
48	Antioxidant Action of Vitamin-C36	5.9	CXCR4, CXCL5, CXCL10, TIMP1, TNFRSF1A, TNF
49	p38 Signaling36	5.6	IL6, IL2RA, IL21, IL2, IL1B, IL18R1
50	Cytokine-cytokine receptor interaction20	5.4	IL10, IL17A, IL18, IL18R1, IL1B, IL2

Compounds related to reactive arthritis according to GeneDecks:

(show top 50)    (show all 296)

id	Compound	Score	Top Affiliating Genes
1	pge232	9.7	CXCL5, CXCL10, TLR4, TLR2, LTF, IL17A
2	estrogen32	9.3	LTF, PHB2, TRH, IL18, MMP1, CD36
3	aspartate32	9.3	SLC11A1, SOD2, CXCR4, LTF, COMP, HSPD1
4	endotoxin32	9.1	ITGAM, BPI, IL18, IL18R1, IFNB1, CXCL5
5	groalpha32	8.9	SELE, IL10, CXCL5, CXCL10, TNF, CCR5
6	h2o232	8.9	TLR4, LTF, TNFRSF1A, HSPD1, IFNB1, IL2RA
7	heparin32 9 18 9	11.8	SOD2, CXCR4, TIMP1, CR1, CCR1, IL18R1
8	n acetylcysteine32	8.8	TIMP1, TLR4, LTF, TP53, HSPD1, IL2RA
9	calcitriol32 42 9 18 9	12.6	CD36, BMP6, ITGAM, IL18R1, IL2, SOD2
10	cysteine32	8.6	ROM1, TIMP1, LTF, COMP, TNFRSF1A, IFNG
11	creatinine32	8.0	SOD2, CXCL10, LTF, COMP, SELE, BPI
12	vitamin d32	7.9	CD36, CD79A, BMP6, ITGAM, IL10, IL2RA
13	polysaccharide32	7.9	HSPD1, IFNB1, CCR5, IL2RA, IL18R1, IL18
14	ifn-alpha32	7.8	IL17A, IL10, IL18, IL2, IL2RA, CXCL10
15	chloroquine32 34 9 9	10.8	CD79A, BMP6, ITGAM, IL10, IL18, CXCL10
16	histamine32 18	8.8	LTF, CCR5, IL2RA, IL2, IL18, ITGAM
17	okt332	7.6	TNFRSF1A, TNF, IFNG, IL6, IL2RA, IL2
18	imiquimod32 42 9 9	10.4	TLR4, TNF, IFNG, IFNB1, IL8, IL6
19	thalidomide32 42 9 9	10.4	CD36, IL10, CYP1A1, TNFRSF1A, TNF, IFNG
20	vegf32	7.2	SOD2, CXCR4, CXCL5, TIMP1, LTF, CRP
21	prednisolone32 9 9	9.1	IL2, IL18R1, IL18, IL10, MMP1, ITGAM
22	cholesterol32 9 18 9	10.0	TIMP1, TLR4, TLR2, CRP, TNFRSF1A, HLA-B
23	sb 20358032 42	8.0	CXCR4, SELE, BSG, BMP6, CD36, TIMP1
24	tacrolimus32 34 9 9	9.9	TNF, BMP6, HLA-B, IFNG, IL2RA, IL2
25	polymyxin b32	6.9	TLR4, SELE, BPI, TLR2, LTF, CR1
26	ly29400232	6.9	TNF, IL8, IL6, IL1B, IL18R1, IL18
27	polyinosinic-polycytidylic acid32	6.8	CXCL10, TLR4, TLR2, HLA-B, IFNG, IFNB1
28	lipoteichoic acid32	6.7	CXCR4, TLR4, TLR2, TNF, HLA-B, IFNB1
29	infliximab32 9 9	8.7	CXCL10, PRTN3, IL10, MMP1, SELE, IL17A
30	etanercept32 9 9	8.7	TIMP1, COMP, CRP, TNFRSF1A, TNF, IFNG
31	simvastatin32 34 42 9 18 9	11.5	IFNB1, CCR5, IL8, IL6, IL18, IL10
32	hydrocortisone32 9 9	8.5	CXCL10, LTF, TNF, TRH, IFNG, ANPEP
33	methotrexate32 34 42 9 9	10.5	IL10, MMP1, CD79A, BMP6, SELE, IL17A
34	pentoxifylline32 9 9	8.4	BMP6, ITGAM, MMP1, LTF, TNF, IFNG
35	superoxide32 18	7.4	HSPD1, IFNB1, CCR1, ANPEP, IL8, IL1B
36	indomethacin32 9 9	8.2	SOD2, TIMP1, LTF, CYP1A1, TNFRSF1A, TNF
37	ccl332	6.2	CXCR4, IL1B, IL18, IL10, IL6, IL8
38	neopterin32	5.9	IL18, IL10, CD79A, IL18R1, LTF, CRP
39	il 1032	5.9	TLR4, BMP6, IL10, IL18, TLR2, TNF
40	herbimycin a32 42	6.8	TNFRSF1A, TNF, IFNG, IFNB1, IL8, IL6
41	lactate32	5.7	CYP1A1, TNF, HLA-B, HSPD1, ANPEP, IL8
42	rantes32	5.6	CXCL5, CCL15, ANPEP, IL6, IL2RA, IL21
43	genistein32 9 18 9	8.5	PRTN3, ITGAM, CD36, SELE, MMP1, MMP8
44	tyrosine32	5.1	SOD2, CXCR4, CXCL5, CXCL10, PRTN3, TIMP1
45	nitric oxide32 9 18 9	7.8	TNF, BPI, SELE, BMP6, ITGAM, MMP8
46	actinomycin d32	4.7	TIMP1, TLR4, TLR2, LTF, CYP1A1, TNFRSF1A
47	retinoic acid32 42 18	6.4	IL6, IL1B, IL18R1, IL18, MMP8, MMP1
48	cyclosporin a32 42	4.8	IL18, IL17A, IL10, MMP8, MMP1, ITGAM
49	cycloheximide32	3.2	SOD2, CXCR4, CXCL10, PRTN3, TIMP1, TLR4
50	dexamethasone32 42 34 9 9	6.9	SOD2, CXCR4, CXCL5, CXCL10, TIMP1, TLR4

Cellular components related to reactive arthritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	9.0	TLR4, TNFRSF1A, TNF, CD36, CD79A, BSG
2	cell surface	GO:009986	8.4	CXCR4, TLR2, CR1, TNFRSF1A, TNF, HSPD1
3	integral to plasma membrane	GO:005887	7.5	TNF, TNFRSF1A, CR1, TLR2, TLR4, SLC11A1
4	external side of plasma membrane	GO:009897	7.4	TNF, TLR2, TLR4, CXCL10, CXCR4, HLA-DRB1
5	plasma membrane	GO:005886	6.4	TRH, TNF, TNFRSF1A, CR1, KLRB1, TLR2
6	extracellular region	GO:005576	6.0	IFNG, TRH, TNFRSF1A, CRP, LTF, TIMP1
7	extracellular space	GO:005615	5.3	SELE, CCL14, IFNB1, IFNG, HSPD1, TNF

Biological processes related to reactive arthritis according to GeneDecks:

(show top 50)    (show all 54)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of macrophage cytokine production	GO:060907	10.3	TLR4, TLR2, CD36
2	chemotaxis	GO:006935	10.3	CXCL5, CXCL10, CCR1, CCR5, CCL16, CCL15
3	cellular response to lipoteichoic acid	GO:071223	10.2	TLR4, TLR2, CD36
4	B cell proliferation	GO:042100	10.1	HSPD1, IFNB1, IL10, CD79A
5	positive regulation of tissue remodeling	GO:034105	10.0	IL21, IL2, IL18
6	dendritic cell chemotaxis	GO:002407	10.0	CXCR4, CCR1, CCR5
7	positive regulation of interleukin-17 production	GO:032740	9.9	IL21, IL2, IL18
8	negative regulation of interleukin-17 production	GO:032700	9.9	TLR4, TLR2, IFNG
9	positive regulation of interleukin-8 production	GO:032757	9.8	IL18, IL1B, TLR2, TLR4
10	positive regulation of osteoclast differentiation	GO:045672	9.8	TNF, IFNG, CCR1, IL17A
11	positive regulation of MHC class II biosynthetic process	GO:045348	9.7	TLR4, IFNG, IL10
12	response to lipopolysaccharide	GO:032496	9.7	CXCL10, TLR4, TNFRSF1A, SELE, SLC11A1
13	negative regulation of interleukin-6 production	GO:032715	9.7	BPI, IL10, TNF, TNFRSF1A, TLR4
14	negative regulation of lipid storage	GO:010888	9.7	CRP, TNF, IL6
15	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	TLR4, TLR2, TNF, IL1B
16	positive regulation of interleukin-12 production	GO:032735	9.7	TLR4, TLR2, HSPD1, IFNG, CD36
17	T-helper 1 type immune response	GO:042088	9.6	TLR4, HLA-DRB1, IL18
18	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	IL1B, IFNG, TNF
19	positive regulation of inflammatory response	GO:050729	9.6	TLR4, TLR2, TNFRSF1A, IL21, IL2, IL18
20	defense response to Gram-positive bacterium	GO:050830	9.5	TLR2, TNF, IL6, CD36
21	lipopolysaccharide-mediated signaling pathway	GO:031663	9.5	TLR4, TLR2, TNF, IL1B, IL18
22	positive regulation of chemokine biosynthetic process	GO:045080	9.5	TNF, IFNG, IL1B
23	protein import into nucleus, translocation	GO:000060	9.4	SLC11A1, TNF, TP53, IFNG
24	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.4	TLR4, TNFRSF1A, TNF, IL1B, CD36, S100A12
25	positive regulation of tumor necrosis factor production	GO:032760	9.4	TLR4, TLR2, TNFRSF1A, IFNG, IL18, CD36
26	cellular response to mechanical stimulus	GO:071260	9.4	TLR4, TNFRSF1A, IL1B, IL18
27	defense response to Gram-negative bacterium	GO:050829	9.3	IL6, TLR4, SLC11A1
28	positive regulation of chemokine production	GO:032722	9.3	TLR4, TLR2, TNF, IL6, IL18
29	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.3	IL1B, IFNG, TNF
30	negative regulation of growth of symbiont in host	GO:044130	9.3	CD36, IL10, IFNG, TNF, TLR2
31	elevation of cytosolic calcium ion concentration	GO:007204	9.3	CXCR4, CCR1, CCR5, IL2, IL1B
32	cell surface receptor signaling pathway	GO:007166	9.2	CXCL10, KLRB1, IFNG, IFNB1, CCR1, CCR5
33	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	IL1B, IFNG, TNF, TLR2, TLR4
34	positive regulation of T cell proliferation	GO:042102	9.2	IL1B, IL21, IL6, IFNG
35	positive regulation of cell proliferation	GO:008284	9.1	CXCL5, CXCL10, PRTN3, TIMP1, CCL14, IL6
36	defense response to bacterium	GO:042742	9.1	SLC11A1, TLR4, LTF, TNFRSF1A, IFNG, IFNB1
37	humoral immune response	GO:006959	9.1	LTF, TNF, IFNG, IFNB1, IL6
38	virus-host interaction	GO:019048	9.0	CXCR4, TNFRSF1A, TP53, HLA-B, HSPD1, CCR5
39	positive regulation of interferon-gamma production	GO:032729	9.0	SLC11A1, TLR4, TNF, HSPD1, IL2, IL1B
40	calcium-mediated signaling	GO:019722	9.0	CXCR4, TNF, CCR5, IL8, SELE
41	response to hypoxia	GO:001666	9.0	CXCR4, TLR4, CRP, TNFRSF1A, TNF, TRH
42	positive regulation of interleukin-6 production	GO:032755	9.0	TLR4, TLR2, TNF, HSPD1, IL6, IL1B
43	cell-cell signaling	GO:007267	8.8	CCR5, CCR1, TRH, CXCL10, CXCL5, CCL16
44	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.8	IL1B, IL6, TNF, TLR2, TLR4
45	cellular response to lipopolysaccharide	GO:071222	8.7	TLR4, IFNG, CCR5, IL8, IL10, CD36
46	cytokine-mediated signaling pathway	GO:019221	8.1	TNFRSF1A, HLA-DRB1, HLA-B, IFNG, IFNB1, CCR1
47	negative regulation of cell proliferation	GO:008285	7.7	SOD2, TNF, TP53, HSPA1B, IFNB1, IL8
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	TP53, TNF, TNFRSF1A, TLR2, TLR4, SLC11A1
49	immune response	GO:006955	6.7	CXCL5, CXCL10, IL21, IL2, IL18R1, IL18
50	inflammatory response	GO:006954	6.5	SLC11A1, IL6, IL1B, IL18, IL17A, IL10

Molecular functions related to reactive arthritis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine (C-C motif) ligand 5 binding	GO:071791	10.2	CCR5, CCR1
2	lipopolysaccharide binding	GO:001530	10.1	BPI, HSPD1, TLR4
3	Gram-positive bacterial cell surface binding	GO:051637	10.0	TLR2, CRP, CD36
4	transmembrane signaling receptor activity	GO:004888	9.6	TLR4, TLR2, KLRB1, CD79A, SELE
5	chemokine activity	GO:008009	9.4	CXCL5, CXCL10, CCL14, CCL16, CCL15, IL8
6	protease binding	GO:002020	9.1	HSPA1B, TP53, TNF, TNFRSF1A
7	cytokine activity	GO:005125	7.3	BMP6, TNF, IFNG, IFNB1, IL6, IL21