PIRA
MCID: RCT015
MIFTS: 62

Reactive Arthritis (PIRA) malady

Bone diseases, Gastrointestinal diseases categories

Summaries for Reactive Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and rheumatoid arthritis, and has symptoms including recurrent urinary infections, tendon rupture/tendinitis/bursitis/tenosynovitis and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds ccl3 and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and lung.

Disease Ontology:8 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia:63 Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in... more...

Aliases & Classifications for Reactive Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
reactive arthritis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

reactive arthritis 8 42 10 48
reiter syndrome 42 48 60
post-infectious reactive arthropathy 42
fiessinger-leroy-reiter syndrome 48
fiessinger leroy reiter syndrome 8
post-dysenteric arthropathy 60
post-bacterial arthropathy 8
postdysenteric arthropathy 8
post-infectious arthritis 42
fiessinger-leroy disease 48
polyarteritis enterica 48
arthritis urethritica 48
arthritis, reactive 60
arthritis, venereal 60
arthritis reactive 44
venereal arthritis 48
reiter's syndrome 42
reiters syndrome 44
reiter's disease 8
reiter disease 8
pira 42


External Ids:

Disease Ontology8 DOID:6196
ICD9CM27 099.3
NCIt39 C34975
MeSH34 D016918
UMLS via Orphanet61 C0085435, C0035012
MESH via Orphanet35 D016918
ICD10 via Orphanet26 M02.8
SNOMED-CT via Orphanet57 129133005, 236690002, 239783001 67224007, more
ICD1025 M02.1, M02.3

Related Diseases for Reactive Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.9SLC11A1, COMP, CCR1, S100A12, MRAP, CXCL5
2rheumatoid arthritis30.9COMP, CCR1, S100A12, CXCL5, IL21, IL17A
3psoriatic arthritis30.5MRAP
4osteoarthritis30.4COMP, CXCL5, IL21, IL17A, MMP8, CEACAM8
5vasculitis30.2IL17A, S100A12
6synovitis30.1COMP, IL17A, MMP8
7keratitis30.1IL17A
8meningitis29.9OMP
9inflammatory bowel disease29.9MRAP, S100A12
10ulcerative colitis29.9CXCL5, IL21, IL17A, SLC11A1
11psoriasis29.9IL17A, MRAP, S100A12
12ankylosing spondylitis10.5
13spondylitis10.5
14rheumatic fever10.4
15septic arthritis10.4
16spondyloarthropathy10.4
17gastroenteritis10.3
18pneumonia10.3
19uveitis10.3
20urethritis10.3
21conjunctivitis10.2
22tuberculosis10.2
23bladder carcinoma10.2
24tetanus10.2
25proctitis10.1
26systemic lupus erythematosus10.1
27pharyngitis10.1
28hidradenitis suppurativa10.1
29tonsillitis10.1
30cervicitis10.1
31diarrhea10.1
32glomerulonephritis10.1
33hidradenitis10.1
34lupus erythematosus10.1
35choroiditis10.0
36urethral syndrome10.0
37hypersensitivity reaction type ii disease10.0IL17A, TRH
38sarcoidosis10.0CXCL5, SLC11A1
39malaria10.0SLC11A1
40leukemia10.0IL17A, CCR1
41leishmaniasis10.0SLC11A1
42atherosclerosis10.0COMP, CCL15, IL17A, MMP8
43periodontitis10.0MMP8, IL17A, OMP
44funisitis10.0MMP8
45cork-handlers' disease10.0CXCL5, IL17A, MMP8, SLC11A1
46obesity10.0IL17A, TRH, COMP
47neisseria meningitidis infection10.0ROM1, OMP
48multiple sclerosis10.0CCR1, IL17A, MMP8, SLC11A1
49peritonitis10.0MMP8
50asthma10.0CCR1, S100A12, CXCL5, IL17A, MMP8, SLC11A1

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to reactive arthritis

Clinical Features for Reactive Arthritis

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48Orphanet
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Symptoms:

48 (show all 28)
  • recurrent urinary infections
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • dysplastic/thick/grooved fingernails
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • urethral anomalies/stenosis/posterior urethral valves/megalocystis
  • malabsorption/chronic diarrhea/steatorrhea
  • nails anomalies
  • enanthema/aphtosa/aphta/leukoplakia
  • pustula/pustulosis
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lung fibrosis
  • photophobia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • inflammatory intestinal disease
  • acute abdominal pain/colic
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • cartilage destruction/chondrolysis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Reactive Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reactive Arthritis

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Anatomical Context for Reactive Arthritis

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32MalaCards
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MalaCards organs/tissues related to Reactive Arthritis:

32
T cells, Eye, Lung, Bone, B cells, Skin, Testes, Heart, Monocytes, Tonsil, Whole blood, Spinal cord, Endothelial, Kidney, Liver, Breast, Nk cells

Animal Models for Reactive Arthritis or affiliated genes

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Publications for Reactive Arthritis

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50PubMed
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Articles related to Reactive Arthritis:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Reactive arthritis in India: a dermatologists' perspective. (23673301)
2013
2
Reactive arthritis induced by bacterial vaginosis: prevention with an effective treatment. (24049604)
2013
3
Reactive arthritis associated with Mycoplasma genitalium urethritis. (24034901)
2013
4
Spectacular evolution of reactive arthritis after early treatment with infliximab. (22542050)
2012
5
Reactive arthritis associated with proctitis due to Chlamydia trachomatis serovar L2b. (22183852)
2012
6
Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland. (21679096)
2011
7
Chlamydia-induced reactive arthritis: hidden in plain sight? (22100286)
2011
8
Live polio vaccine exposure while receiving anti-TNF therapy for reactive arthritis. (20536606)
2010
9
Similar erythrocyte sedimentation rate and C-reactive protein sensitivities at the onset of septic arthritis, osteomyelitis, acute rheumatic fever. (21589835)
2010
10
Macular infarction associated with reactive arthritis. (21052513)
2010
11
Is the role of Chlamydia trachomatis underestimated in patients with suspected reactive arthritis? (20374382)
2010
12
The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study. (20836849)
2010
13
Detection and frequency of Chlamydia trachomatis DNA in synovial samples from Tunisian patients with reactive arthritis and undifferentiated oligoarthritis. (19159429)
2009
14
Reactive arthritis due to Chlamydia psittaci associated with HLA-B27 genotype. (19485846)
2009
15
Reactive arthritis. (19341180)
2009
16
Sialylation of Campylobacter jejuni lipo-oligosaccharides is associated with severe gastro-enteritis and reactive arthritis. (19631279)
2009
17
Bilateral dacryoadenitis: a new addition to the spectrum of reactive arthritis? (19300169)
2009
18
Toll-like receptor 2 variants are associated with acute reactive arthritis. (18975326)
2008
19
A case of post-streptococcal reactive arthritis and acute nephritis after bacterial endophthalmitis due to Streptococcus pyogenes. (18493763)
2008
20
Circulating levels of osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor-kappa B ligand, and high-sensitivity C-reactive protein in patients with active rheumatoid arthritis randomized to etanercept alone or in combination with methotrexate. (18612923)
2008
21
Erosive arthritis in systemic lupus erythematosus is associated with high serum C-reactive protein and anti-cyclic citrullinated peptide antibodies. (19109734)
2008
22
Reactive arthritis and the investigation of novel organisms. (17244958)
2007
23
Reiter's syndrome (reactive arthritis) and travelers' diarrhea. (16412110)
2006
24
Antimicrobial treatment for Chlamydia induced reactive arthritis. (15708913)
2005
25
Poststreptococcal reactive arthritis with thoracic spine involvement in an adult. (16206358)
2005
26
Shigella induced reactive arthritis. (15769909)
2005
27
Cellular and humoral markers of systemic inflammation in acute reactive arthritis and early rheumatoid arthritis. (15124937)
2004
28
HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. (15084505)
2004
29
Post-streptococcal reactive arthritis and glomerulonephritis in an adult. (14579166)
2003
30
Reactive arthritis and serum levels of mannose binding lectin -- lack of association. (12519401)
2003
31
Synovial lymphocyte responses to microbiologic antigen stimulation indicate the etiology of undifferentiated and reactive arthritis, and possibly of rheumatoid arthritis: Comment on the article by Schnarr et al. (12209542)
2002
32
Reactive arthritis associated with genital tract group A streptococcal infection. (12387782)
2002
33
Sexual and enteric bacterial infections eliciting reactive arthritis. (11791343)
2001
34
Sexually-acquired reactive arthritis. (11236622)
2001
35
Reactive arthritis. (10910183)
2000
36
Modulation of peripheral blood mononuclear cell activation status during Salmonella-triggered reactive arthritis. (10524675)
1999
37
Increased IgA rheumatoid factor and V(H)1 associated cross reactive idiotype expression in patients with Lyme arthritis and neuroborreliosis. (10577962)
1999
38
Common intra-articular T cell expansions in patients with reactive arthritis: identical beta-chain junctional sequences and cytotoxicity toward HLA-B27. (10201900)
1999
39
Reactive arthritis. (10599344)
1999
40
A clinical and serological comparison of group A versus non-group A streptococcal reactive arthritis and throat culture negative cases of post-streptococcal reactive arthritis. (10381484)
1999
41
A case of post-streptococcal reactive arthritis. (10628129)
1999
42
Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? (9640127)
1998
43
In situ hybridisation and direct fluorescence antibodies for the detection of Chlamydia trachomatis in synovial tissue from patients with reactive arthritis. (10193319)
1998
44
Reactive arthritis in a patient with simultaneous parvovirus B19 infection and Clostridium difficile diarrhoea. (9117160)
1997
45
Enterobacteria-infected T cells as antigen-presenting cells for cytotoxic CD8 T cells: a contribution to the self-limitation of cellular immune reactions in reactive arthritis? (9129075)
1997
46
Poststreptococcal reactive arthritis, clinical course, and outcome in 6 adult patients. (8523350)
1995
47
Reactivation of rheumatoid arthritis and development of leukocytoclastic vasculitis in a patient receiving granulocyte colony-stimulating factor for Felty's syndrome. (7539978)
1995
48
HSP70-Hom NcoI polymorphism and HLA-associations in the Finnish population and in patients with ankylosing spondylitis or reactive arthritis. (9098422)
1994
49
The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. (1370300)
1992
50
Reactive arthritis due to hidradenitis suppurativa mimicking osteomyelitis. (1891742)
1991

Genetic Variations for Reactive Arthritis

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Expression for genes affiliated with Reactive Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for genes affiliated with Reactive Arthritis

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Sources:
53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Reactive Arthritis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ccl344 2811.4CCL16, CCL15, CCR1, CXCL5
2ccl444 2811.4IL17A, CXCL5, CCR1, CCL15
3glycosaminoglycan4410.4COMP, CCR1, MMP8
4rantes4410.4IL17A, CXCL5, CCR1, CCL14, CCL16
5p0024410.4MMP8, IL17A, COMP
6pge24410.3MMP8, IL17A, CXCL5, CCR1
7oligonucleotide4410.3COMP, S100A12, TRH, CXCL5, IL17A, MMP8
8zinc44 2411.2S100A12, OMP, CXCL5, MMP8, SLC11A1
9nitric oxide44 11 2412.1SLC11A1, MMP8, IL17A, CXCL5, CCR1
10calcium44 49 11 2413.0CCL15, CCL16, COMP, KLRB1, CCR1, S100A12
11hydrogen44 2410.9COMP, TRH, MMP8, SLC11A1

GO Terms for genes affiliated with Reactive Arthritis

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16Gene Ontology
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Cellular components related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CEACAM8, MMP8, IL17A, IL21, CXCL5, CCL15

Biological processes related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive chemotaxisGO:05091810.3CCL15, CCL16
2chemotaxisGO:00693510.3CCL16, CCL15, CCR1, CXCL5
3cell-cell signalingGO:00726710.2CCL16, CCL15, CCR1, TRH, CXCL5, IL17A
4cellular calcium ion homeostasisGO:00687410.2CCL14, CCL15, CCR1
5inflammatory responseGO:00695410.2SLC11A1, IL17A, S100A12, CCR1, CCL16
6immune responseGO:00695510.2CEACAM8, CCL16, CCL14, CCL15, CCR1, CXCL5
7positive regulation of osteoclast differentiationGO:04567210.1IL17A, CCR1

Molecular functions related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.3CCL15, CCL16
2chemokine activityGO:0080099.9CXCL5, CCL15, CCL14, CCL16

Products for genes affiliated with Reactive Arthritis

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Sources for Reactive Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet