PIRA
MCID: RCT015
MIFTS: 57

Reactive Arthritis (PIRA) malady

Rare diseases, Bone diseases, Gastrointestinal diseases categories
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Summaries for Reactive Arthritis

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NIH Rare Diseases:42 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards based summary: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and pneumonia, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, hyperkeratosis/ainhum/hyperkeratotic skin fissures and pustula/pustulosis. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein). The compounds urea and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and lung.

Disease Ontology:8 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia:65 Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in... more...

Aliases & Classifications for Reactive Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 44Novoseek, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Reactive Arthritis, Aliases & Descriptions:

Name: Reactive Arthritis 8 42 10 48
Reiter Syndrome 42 48 62
Fiessinger Leroy Reiter Syndrome 8 62
Post-Bacterial Arthropathy 8 62
Post-Infectious Arthritis 42 62
Arthritis Urethritica 48 62
Reiters Syndrome 44 62
Reiter's Disease 8 62
Post-Infectious Reactive Arthropathy 42
Fiessinger-Leroy-Reiter Syndrome 48
Post-Dysenteric Arthropathy 62
 
Postdysenteric Arthropathy 8
Fiessinger-Leroy Disease 48
Polyarteritis Enterica 48
Arthritis, Venereal 62
Arthritis, Reactive 62
Arthritis Reactive 44
Venereal Arthritis 48
Reiter's Syndrome 42
Reiter Disease 8
Pira 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
reactive arthritis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:6196
NCIt39 C34975
ICD9CM27 099.3
MeSH34 D016918
MESH via Orphanet35 D016918
ICD10 via Orphanet26 M02.8
UMLS via Orphanet63 C0035012, C0085435
ICD1025 M02.1, M02.3

Related Diseases for Reactive Arthritis

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Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to reactive arthritis

Symptoms for Reactive Arthritis

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Symptoms:

48 (show all 28)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • pustula/pustulosis
  • enanthema/aphtosa/aphta/leukoplakia
  • nails anomalies
  • dysplastic/thick/grooved fingernails
  • malabsorption/chronic diarrhea/steatorrhea
  • urethral anomalies/stenosis/posterior urethral valves/megalocystis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • cartilage destruction/chondrolysis
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • acute abdominal pain/colic
  • inflammatory intestinal disease
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • photophobia
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • recurrent urinary infections
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling

HPO human phenotypes related to Reactive Arthritis:

(show all 26)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 abnormality of the urethra hallmark (90%) HP:0000795
3 hyperkeratosis hallmark (90%) HP:0000962
4 abnormality of the fingernails hallmark (90%) HP:0001231
5 arthritis hallmark (90%) HP:0001369
6 limitation of joint mobility hallmark (90%) HP:0001376
7 joint swelling hallmark (90%) HP:0001386
8 malabsorption hallmark (90%) HP:0002024
9 osteomyelitis hallmark (90%) HP:0002754
10 arthralgia hallmark (90%) HP:0002829
11 inflammatory abnormality of the eye hallmark (90%) HP:0100533
12 enthesitis hallmark (90%) HP:0100686
13 cartilage destruction hallmark (90%) HP:0100773
14 pustule hallmark (90%) HP:0200039
15 abdominal pain typical (50%) HP:0002027
16 inflammation of the large intestine typical (50%) HP:0002037
17 abnormality of the pleura typical (50%) HP:0002103
18 recurrent urinary tract infections occasional (7.5%) HP:0000010
19 photophobia occasional (7.5%) HP:0000613
20 abnormality of the aortic valve occasional (7.5%) HP:0001646
21 abnormality of the pericardium occasional (7.5%) HP:0001697
22 weight loss occasional (7.5%) HP:0001824
23 respiratory insufficiency occasional (7.5%) HP:0002093
24 pulmonary fibrosis occasional (7.5%) HP:0002206
25 abnormality of temperature regulation occasional (7.5%) HP:0004370
26 abnormal tendon morphology occasional (7.5%) HP:0100261

Drugs & Therapeutics for Reactive Arthritis

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Drug clinical trials:

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Search NIH Clinical Center for Reactive Arthritis

Genetic Tests for Reactive Arthritis

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Anatomical Context for Reactive Arthritis

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MalaCards organs/tissues related to Reactive Arthritis:

32
Eye, T cells, Lung, Bone, Skin, B cells, Neutrophil, Heart, Whole blood, Spinal cord, Testes, Tonsil, Liver, Breast, Monocytes, Nk cells, Endothelial

Animal Models for Reactive Arthritis or affiliated genes

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Publications for Reactive Arthritis

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Articles related to Reactive Arthritis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Clinical characteristics of Japanese patients with reactive arthritis following intravesical BCG therapy for bladder cancer. (24947826)
2014
2
High frequency of reactive arthritis in adults after Yersinia pseudotuberculosis O:1 outbreak caused by contaminated grated carrots. (23852698)
2013
3
TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis. (23207279)
2013
4
Methicillin-resistant Staphylococcus aureus induced reactive arthritis treated with systemic corticosteroid. (23492683)
2013
5
The role of Chlamydia and Chlamydophila infections in reactive arthritis. (22214635)
2012
6
Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland. (21679096)
2011
7
Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy. (21181220)
2011
8
The evolving story of Chlamydia-induced reactive arthritis. (20445454)
2010
9
Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. (20155838)
2010
10
Reactive arthritis due to Clostridium difficile. (20171133)
2010
11
Live polio vaccine exposure while receiving anti-TNF therapy for reactive arthritis. (20536606)
2010
12
Detection and frequency of Chlamydia trachomatis DNA in synovial samples from Tunisian patients with reactive arthritis and undifferentiated oligoarthritis. (19159429)
2009
13
Reactive arthritis associated with hidradenitis suppurativa. (19397229)
2009
14
Reactive arthritis associated with L2b lymphogranuloma venereum proctitis. (19478106)
2009
15
Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis in Tunisia. (19152094)
2009
16
Toll-like receptor 2 variants are associated with acute reactive arthritis. (18975326)
2008
17
Antibacterial antibodies for some enterobacteria in sera of patients with reactive arthritis and other rheumatoid diseases. (19284164)
2008
18
Frequency of recent parvovirus infection in patients examined for acute reactive arthritis. A study with combinatorial parvovirus serodiagnostics. (17543157)
2007
19
Clinical presentations of chlamydial and non-chlamydial reactive arthritis. (16432687)
2006
20
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
21
Human immunodeficiency virus related reactive arthritis in Zambia. (15996068)
2005
22
Cellular and humoral markers of systemic inflammation in acute reactive arthritis and early rheumatoid arthritis. (15124937)
2004
23
Management of sexually acquired reactive arthritis in 19 North Thames GUM clinics. (15038868)
2004
24
Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. (14739472)
2004
25
Unusual causes of reactive arthritis: Leptospira and Coxiella burnetii. (14576997)
2003
26
Yersinia enterocolitica O:3 isolated from patients with or without reactive arthritis induces polyclonal activation of B cells and autoantibody production in vivo. (14567555)
2003
27
Chlamydial conjunctivitis (in adults), uveitis, and reactive arthritis, including SARA. Sexually acquired reactive arthritis. (12473284)
2002
28
Bacteria-Triggered reactive arthritis: implications for antibacterial treatment. (11293645)
2001
29
European guideline for the management of sexually acquired reactive arthritis. (11589806)
2001
30
Diagnostic evaluation of classification criteria for RA and reactive arthritis. (10836957)
2000
31
Management of reactive arthritis in a juvenile gorilla (Gorilla gorilla gorilla) with long-term sulfasalazine therapy. (11428403)
2000
32
Index of suspicion. Case #1. Diagnosis: Nongroup A poststreptococcal reactive arthritis. (11041668)
2000
33
Pathogenesis of reactive arthritis. (10225663)
1999
34
Recurrent reactive arthritis associated with urinary tract infection by Escherichia coli. (10529156)
1999
35
Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Heat-shock protein 60 drives a major immune response. (9485090)
1998
36
Detection of Chlamydia trachomatis in peripheral blood leukocytes of reactive arthritis patients by polymerase chain reaction. (9778233)
1998
37
Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? (9640127)
1998
38
Reactive arthritis in a patient with simultaneous parvovirus B19 infection and Clostridium difficile diarrhoea. (9117160)
1997
39
Characterization of serum antibody response to chlamydiae in patients with sexually acquired reactive arthritis. (9453389)
1997
40
Comment on the article 'Reactive arthritis, beta-haemolytic Streptococcus and Staphylococcus aureus' by D. N. Leitch and C. D. Holland. (9189069)
1997
41
Cross-reactivity between Borrelia burgdorferi and "arthrogenic" bacteria in sera from patients with reactive arthritis. (8673811)
1996
42
Reactive arthritis after an insect bite--suspect the unsuspected. (8609869)
1996
43
Antigen-presenting cells but not lymphocytes in the joint may indicate the cause of reactive arthritis. (8948293)
1996
44
Poststreptococcal reactive arthritis, clinical course, and outcome in 6 adult patients. (8523350)
1995
45
Fast food arthritis--a clinico-pathologic study of post-Salmonella reactive arthritis. (8991996)
1995
46
Reactive arthritis following Clostridium difficile colitis. (7863666)
1995
47
Poststreptococcal reactive arthritis mimicking acute septic arthritis: a hospital-based study. (7593582)
1995
48
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. (7923879)
1994
49
Hepatitis B immunisation and reactive arthritis. (7804071)
1994
50
Salmonella-specific antibodies in reactive arthritis. (1955713)
1991

Variations for Reactive Arthritis

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Expression for genes affiliated with Reactive Arthritis

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Expression patterns in normal tissues for genes affiliated with Reactive Arthritis

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Pathways for genes affiliated with Reactive Arthritis

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Compounds for genes affiliated with Reactive Arthritis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB
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Compounds related to Reactive Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1urea44 24 1111.6BPI, MMP8
2endotoxin449.3BPI, CXCL5
3fmlp449.1CXCL5, BPI
4vegf449.0BPI, CXCL5, MMP8
5zinc44 249.9SLC11A1, OMP, MMP8, CXCL5
6calcium44 50 24 1111.7CXCL5, SLC11A1, OMP, MMP8
7nitric oxide44 24 1110.7CXCL5, MMP8, BPI, SLC11A1

GO Terms for genes affiliated with Reactive Arthritis

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Biological processes related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.5SLC11A1, BPI
2immune responseGO:0069558.5IL21, BPI, CXCL5

Products for genes affiliated with Reactive Arthritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Reactive Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet