MCID: RCT015
MIFTS: 65

Reactive Arthritis

Categories: Rare diseases, Gastrointestinal diseases, Bone diseases

Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis 12 72 49 55 14
Reiter Syndrome 49 55 69
Arthritis, Reactive 41 69
Reiter's Syndrome 72 49
Reiter Disease 12 55
Post-Infectious Reactive Arthropathy 49
Fiessinger Leroy Reiter Syndrome 12
Fiessinger-Leroy-Reiter Syndrome 55
Post-Dysenteric Arthropathy 69
Post-Bacterial Arthropathy 12
Postdysenteric Arthropathy 12
Post-Infectious Arthritis 49
Fiessinger-Leroy Disease 55
Polyarthritis Enterica 55
Arthritis Urethritica 55
Arthritis, Venereal 69
Venereal Arthritis 55
Arthritis Reactive 51
Reiter's Disease 12
Reiters Syndrome 51
Pira 49

Characteristics:

Orphanet epidemiological data:

55
reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Reactive Arthritis

NIH Rare Diseases : 49 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain.  Last updated: 3/31/2012

MalaCards based summary : Reactive Arthritis, also known as reiter syndrome, is related to spondyloarthropathy 1 and arthritis, and has symptoms including recurrent urinary tract infections, conjunctivitis and photophobia. An important gene associated with Reactive Arthritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rifampin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Disease Ontology : 12 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : 72 Reactive arthritis, also known as Reiter\'s syndrome, is a form of inflammatory arthritis that develops... more...

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 31.7 CD79A CRP HLA-B IL17A TNF
2 arthritis 30.6 IFNG IL10 IL17A IL6 TNF
3 cat-scratch disease 29.9 HSPD1 IFNG
4 streptococcal toxic-shock syndrome 29.7 IL6 TNF
5 spondylitis 29.6 CRP HLA-B IL17A IL6 TNF
6 anterior uveitis 29.6 HLA-B IL6 TNF
7 myelitis 29.5 IL17A IL6 TNF
8 stromal keratitis 29.5 IL17A IL6 TNF
9 psoriatic arthritis 29.5 CRP HLA-B IL17A TNF
10 synovitis 29.4 CRP IL6 TNF
11 urethritis 29.4 CD79A HSPD1
12 uveitis 29.2 HLA-B IFNG IL10 IL17A TNF
13 pneumonia 29.2 CRP IL10 IL6 TNF
14 strongyloidiasis 29.1 CD79A IFNG
15 bacterial vaginosis 29.1 IL10 IL6 TNF
16 prostatitis 29.1 IL10 IL6 TNF
17 rheumatic heart disease 29.1 IL10 IL6 TNF
18 spondyloarthropathy 29.1 HLA-B IFNG IL10 IL17A IL6 TNF
19 tonsillitis 29.1 CD79A IFNG IL6 TNF
20 tetanus 29.1 CD79A IFNG IL10
21 colitis 29.1 IFNG IL10 IL17A IL6 TNF
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.0 HSPD1 IFNG IL10 IL17A
23 mycobacterium tuberculosis 1 28.9 HSPD1 IFNG IL10 IL17A TNF
24 erythema multiforme 28.9 CD79A IFNG TNF
25 gastroenteritis 28.9 CRP IFNG IL10 IL6 TNF
26 osteomyelitis 28.9 IFNG IL10 IL6 TNF
27 toxic shock syndrome 28.9 IFNG IL10 IL6 TNF
28 vasculitis 28.6 BPI CD79A CRP TNF
29 psoriasis 28.5 IFNG IL10 IL17A IL6 TNF
30 chlamydia 28.4 CD79A CRP HSPD1 IFNG IL10 IL6
31 rheumatic disease 28.3 CRP HLA-B IFNG IL10 TNF
32 brucellosis 28.3 CRP IFNG IL10 IL6 TNF
33 otitis media 28.3 CD79A IL10 IL6 TNF
34 appendicitis 28.2 CRP IL10 IL6 MMP8 TNF
35 bacterial meningitis 28.2 CRP IL10 IL6 MMP8 TNF
36 ulcerative colitis 27.9 BPI CRP IFNG IL10 IL6 TNF
37 meningitis 27.8 CRP IFNG IL10 IL6 OMP TNF
38 rheumatoid arthritis 27.7 CD79A CRP HLA-B IFNG IL10 IL17A
39 systemic lupus erythematosus 27.3 CD79A CRP IFNG IL10 IL17A IL6
40 inflammatory bowel disease 26.6 BPI CD79A CRP HLA-B IFNG IL10
41 septic arthritis 11.7
42 shigellosis 11.3
43 b-cell growth factor 10.5 IFNG IL6
44 far eastern spotted fever 10.5 HSPD1 IFNG
45 periodontitis, chronic 10.4 IL6 MMP8
46 scorpion envenomation 10.4 IL6 TNF
47 cold agglutinin disease 10.4 CRP IL6
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
49 critical limb ischemia 10.4 IL6 TNF
50 diabetic foot ulcers 10.3 CRP IL6

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

55 31 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent urinary tract infections 55 31 occasional (7.5%) Occasional (29-5%) HP:0000010
2 conjunctivitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000509
3 photophobia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000613
4 hyperkeratosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000962
5 arthritis 55 31 hallmark (90%) Very frequent (99-80%) HP:0001369
6 joint swelling 55 31 hallmark (90%) Very frequent (99-80%) HP:0001386
7 joint stiffness 55 31 hallmark (90%) Very frequent (99-80%) HP:0001387
8 aortic regurgitation 55 31 occasional (7.5%) Occasional (29-5%) HP:0001659
9 pericarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001701
10 weight loss 55 31 occasional (7.5%) Occasional (29-5%) HP:0001824
11 fever 55 31 occasional (7.5%) Occasional (29-5%) HP:0001945
12 diarrhea 55 31 hallmark (90%) Very frequent (99-80%) HP:0002014
13 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
14 inflammation of the large intestine 55 31 frequent (33%) Frequent (79-30%) HP:0002037
15 respiratory insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0002093
16 abnormality of the pleura 55 31 frequent (33%) Frequent (79-30%) HP:0002103
17 pulmonary fibrosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002206
18 osteomyelitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0002754
19 arthralgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002829
20 dystrophic fingernails 55 31 hallmark (90%) Very frequent (99-80%) HP:0008391
21 recurrent aphthous stomatitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0011107
22 cognitive impairment 55 31 hallmark (90%) Very frequent (99-80%) HP:0100543
23 enthesitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100686
24 cartilage destruction 55 31 hallmark (90%) Very frequent (99-80%) HP:0100773
25 pustule 55 31 hallmark (90%) Very frequent (99-80%) HP:0200039
26 abnormality of the nail 55 Very frequent (99-80%)

MGI Mouse Phenotypes related to Reactive Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 IL17A IL6 MMP8 OMP TNF TRH
2 neoplasm MP:0002006 9.63 IL6 MMP8 TNF CD79A IFNG IL10
3 no phenotypic analysis MP:0003012 9.5 OMP TNF TRH CD79A IFNG IL10
4 respiratory system MP:0005388 9.1 IL17A IL6 OMP TNF IFNG IL10

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 3 13292-46-1 5381226 5458213
2
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
3
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
4 Anti-Bacterial Agents Phase 3,Phase 2
5 Anti-Infective Agents Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 3,Phase 2
7 Cytochrome P-450 CYP3A Inducers Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 3
9 Antimalarials Phase 3
10 Antiprotozoal Agents Phase 3
11 Antiparasitic Agents Phase 3
12 Antitubercular Agents Phase 3
13
Infliximab Approved Phase 2 170277-31-3
14 interferons Phase 2
15 Gastrointestinal Agents Phase 2
16 Dermatologic Agents Phase 2
17 Interferon-gamma Phase 2
18 Antirheumatic Agents Phase 2
19 Antiviral Agents Phase 2
20
Adalimumab Approved 331731-18-1 16219006
21
Etanercept Approved, Investigational 185243-69-0
22
Ofloxacin Approved 82419-36-1 4583
23
Levofloxacin Approved, Investigational 100986-85-4 149096
24
Rifaximin Approved, Investigational 80621-81-4 6436173
25 Renal Agents
26 Topoisomerase Inhibitors
27 Cytochrome P-450 CYP1A2 Inhibitors
28 Cytochrome P-450 Enzyme Inhibitors
29 Anti-Inflammatory Agents
30 Anti-Inflammatory Agents, Non-Steroidal
31 rifamycin SV
32 Rifamycins
33 Cola Nutraceutical

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2 Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis Completed NCT03358134 Phase 3 Secukinumab
3 New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis Unknown status NCT00244179 Phase 2 interferon-gamma;infliximab;dmard
4 Study of Long-Term Antibiotic Treatment in Reactive Arthritis Completed NCT00621387 ofloxacin and roxithromycin;placebo
5 Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study Completed NCT01179451
6 Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological Therapy Completed NCT01219257
7 The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis Completed NCT00001375
8 The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides Completed NCT00768950
9 Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients Completed NCT00001679
10 Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration Recruiting NCT03038386
11 Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD Active, not recruiting NCT02498301 Rifaximin;Placebo

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

38
Eye, T Cells, Bone, Colon, B Cells, Tonsil, Neutrophil

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 585)
# Title Authors Year
1
Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. ( 29073348 )
2018
2
Chronic reactive arthritis associated with prostatitis caused by<i>Neisseria meningitidis</i>. ( 29374652 )
2018
3
Potential risk factors for reactive arthritis and persistence of symptoms at 2A years: a case-control study with longitudinal follow-up. ( 29139030 )
2018
4
Reactive Arthritis. ( 28292540 )
2017
5
Strongly positive anti-CCP antibodies in patients with sacroiliitis or reactive arthritis post-E.A coli infection: A mini case-series based review. ( 28589668 )
2017
6
The Case of Reactive Arthritis Secondary to Echinococcus Infestation. ( 28607793 )
2017
7
IL-17 and IFN-I^ producing NK and I^I'-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis. ( 28390966 )
2017
8
Reactive Arthritis Caused by Yersinia enterocolitica Enteritis. ( 28502944 )
2017
9
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
10
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
11
Reactive arthritis associated with<i>Strongyloides stercoralis</i>: Report of an uncommon relation. ( 29114491 )
2017
12
HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients. ( 29135969 )
2017
13
Understanding TMJ reactive arthritis. ( 28760073 )
2017
14
Human Leukocyte Antigen-B27: The Genetic Predisposition Leading to Reactive Arthritis during Induction Phase Chemotherapy for Acute Myeloid Leukemia. ( 29200696 )
2017
15
Epidemiology: Time to revisit the concept of reactive arthritis. ( 28490789 )
2017
16
A bicentre retrospective study of features and outcomes of patients with reactive arthritis. ( 28238883 )
2017
17
Streptococcal tonsillitis related reactive arthritis - clinical, ultrasound imaging and immunohistochemical study. ( 29250657 )
2017
18
Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing I^I'T Cells. ( 28944217 )
2017
19
Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation. ( 28576785 )
2017
20
Yersinia enterocolitica biotype 1A: a possible new trigger of reactive arthritis. ( 28918489 )
2017
21
Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis. ( 28496443 )
2017
22
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
23
The incidence of sexually acquired reactive arthritis: a systematic literature review. ( 27480977 )
2016
24
Anti-TNF treatment of reactive arthritis. A monocentric experience. ( 27236263 )
2016
25
Evolution over thirty years of the profile of inpatients with reactive arthritis in a tertiary rheumatology unit. ( 27600249 )
2016
26
Clostridium difficile associated reactive arthritis: Case report and literature review. ( 26743187 )
2016
27
THE SOURCE OF INFECTION AND THE MOST FREQUENT CAUSES OF REACTIVE ARTHRITIS IN KOSOVO. ( 27482162 )
2016
28
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016
29
Post-streptococcal reactive arthritis: where are we now. ( 27520996 )
2016
30
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
31
Epidemiology of Clostridium difficile Infection-Associated Reactive Arthritis in Children: An Underdiagnosed, Potentially Morbid Condition. ( 27182697 )
2016
32
Trafficking of antigens from gut to sacroiliac joints and spine in reactive arthritis and spondyloarthropathies: Mainly through lymphatics? ( 26968111 )
2016
33
Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )
2016
34
Early treatment of reactive arthritis with etanercept and 2 years follow-up. ( 27269651 )
2016
35
Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )
2016
36
Sexually acquired reactive arthritis. ( 27037393 )
2016
37
Clostridium difficile Enterocolitis and Reactive Arthritis: A Case Report and Review of the Literature. ( 27190666 )
2016
38
A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman. ( 27513386 )
2016
39
Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )
2016
40
Recombinant Salmonella typhimurium Outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce IL17/IL23 in patients with Reactive arthritis and undifferentiated spondyloarthropathy. ( 27060348 )
2016
41
Microbe-triggered arthropathies: reactive arthritis and beyond. ( 27232885 )
2016
42
Reactive Arthritis Caused by Urinary Tract Infection. ( 27150879 )
2016
43
European guideline for managing sexually acquired reactive arthritis. ( 26647401 )
2016
44
Association between Giardia and arthritis or joint pain in a large health insurance cohort: could it be reactive arthritis? ( 27640995 )
2016
45
Reactive arthritis following a Microsporidia infection. ( 27020082 )
2016
46
Reactive arthritis at the Sydney Sexual Health Centre 1992-2012: declining despite increasing chlamydia diagnoses. ( 26378192 )
2015
47
Modes of presentation of reactive arthritis based on the affected joints. ( 25870477 )
2015
48
Concurrent peritonsillar abscess and poststreptococcal reactive arthritis complicating acute streptococcal tonsillitis in a young healthy adult: a case report. ( 25885601 )
2015
49
Do IgA antibodies to Chlamydia trachomatis have protective role in humoral immunity: a study in reactive arthritis patients. ( 26482506 )
2015
50
Circinate balanitis as the presenting symptom of sexually-acquired reactive arthritis: a case report. ( 25918330 )
2015

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 BPI CD79A CRP HLA-B IFNG IL10
2
Show member pathways
13.26 HLA-B IFNG IL10 IL17A IL6 TNF
3
Show member pathways
12.61 HLA-B HSPD1 IFNG IL10 IL17A IL6
4
Show member pathways
12.53 CD79A IFNG IL10 TNF
5
Show member pathways
12.52 IFNG IL10 IL17A IL6 TNF
6
Show member pathways
12.51 IFNG IL10 IL17A IL6 TNF
7 12.48 CD79A IFNG IL10 IL17A TNF
8
Show member pathways
12.46 IFNG IL10 IL6 TNF
9
Show member pathways
12.35 IFNG IL10 IL17A IL6 TNF
10
Show member pathways
12.28 CRP IFNG IL6 TNF
11
Show member pathways
12.28 IFNG IL17A IL6 TNF
12 12.12 HSPD1 IL10 IL6 TNF
13 12.11 HSPD1 IFNG IL10 IL6 TNF
14 11.93 IFNG IL6 TNF
15 11.92 IL10 IL17A IL6 TNF
16 11.87 CD79A IFNG IL10 IL6 TNF
17 11.83 IFNG IL10 IL6 TNF
18
Show member pathways
11.8 IFNG IL17A IL6
19 11.77 IFNG IL17A IL6 TNF
20 11.76 IFNG IL10 IL6
21 11.72 IL10 IL6 TNF
22 11.7 IFNG IL10 IL17A TNF
23 11.65 IL10 IL6 TNF
24 11.65 IFNG IL10 IL6 TNF
25
Show member pathways
11.63 IFNG IL6 TNF
26
Show member pathways
11.57 IFNG IL10 IL17A IL6 TNF
27 11.55 HSPD1 IL6 TNF
28 11.52 IFNG IL6 TNF
29 11.48 IL10 IL6 TNF
30 11.44 IFNG IL6 TNF
31 11.42 IFNG IL10 IL6 TNF
32
Show member pathways
11.33 IFNG IL10 TNF
33 11.31 IL10 IL6 TNF
34
Show member pathways
11.31 HLA-B IFNG IL10 IL17A IL6 TNF
35 11.21 IFNG IL10 IL6 TNF
36 11.15 IL10 IL17A IL6 TNF
37 11.06 IFNG IL17A IL6 TNF
38 11.02 IL6 TNF
39 10.98 CRP IL6 TNF
40 10.73 IFNG IL10 IL6 TNF

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BPI CRP IFNG IL10 IL17A IL6
2 extracellular space GO:0005615 9.28 BPI CRP HSPD1 IFNG IL10 IL17A

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 CRP IFNG IL6 TNF
2 inflammatory response GO:0006954 9.88 CRP IL10 IL17A IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.79 IL10 IL6 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.77 IL10 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.75 CRP IL6 TNF
6 response to glucocorticoid GO:0051384 9.73 IL10 IL6 TNF
7 humoral immune response GO:0006959 9.7 IFNG IL6 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.67 HSPD1 IL6 TNF
9 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
10 regulation of receptor activity GO:0010469 9.63 IFNG IL10 IL17A IL6 TNF TRH
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
12 positive regulation of macrophage activation GO:0043032 9.61 HSPD1 IL10
13 negative regulation of growth of symbiont in host GO:0044130 9.6 IL10 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 TNF
15 B cell proliferation GO:0042100 9.58 CD79A HSPD1 IL10
16 endothelial cell apoptotic process GO:0072577 9.57 IL10 TNF
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
18 negative regulation of interleukin-8 production GO:0032717 9.54 BPI IL10
19 positive regulation of interleukin-23 production GO:0032747 9.51 IFNG IL17A
20 negative regulation of interleukin-6 production GO:0032715 9.5 BPI IL10 TNF
21 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
23 positive regulation of osteoclast differentiation GO:0045672 9.43 IFNG IL17A TNF
24 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
25 immune response GO:0006955 9.17 BPI HLA-B IFNG IL10 IL17A IL6
26 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL17A IL6 TNF

Sources for Reactive Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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