PIRA
MCID: RCT015
MIFTS: 57

Reactive Arthritis (PIRA) malady

Rare diseases, Bone diseases, Gastrointestinal diseases categories

Summaries for Reactive Arthritis

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and rheumatoid arthritis, and has symptoms including enanthema/aphtosa/aphta/leukoplakia, cartilage destruction/chondrolysis and pustula/pustulosis. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein). The compounds urea and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and lung.

Disease Ontology:9 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia:66 Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in... more...

Aliases & Classifications for Reactive Arthritis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
reactive arthritis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

reactive arthritis 9 44 11 50
reiter syndrome 44 50 63
post-infectious reactive arthropathy 44
fiessinger-leroy-reiter syndrome 50
fiessinger leroy reiter syndrome 9
post-dysenteric arthropathy 63
post-bacterial arthropathy 9
postdysenteric arthropathy 9
post-infectious arthritis 44
fiessinger-leroy disease 50
polyarteritis enterica 50
arthritis urethritica 50
arthritis, reactive 63
arthritis, venereal 63
arthritis reactive 46
venereal arthritis 50
reiter's syndrome 44
reiters syndrome 46
reiter's disease 9
reiter disease 9
pira 44


External Ids:

Disease Ontology9 DOID:6196
NCIt41 C34975
MeSH36 D016918
ICD9CM28 099.3
UMLS via Orphanet64 C0085435, C0035012
MESH via Orphanet37 D016918
ICD10 via Orphanet27 M02.8
SNOMED-CT via Orphanet60 129133005, 236690002, 239783001 67224007, more
ICD1026 M02.1, M02.3

Related Diseases for Reactive Arthritis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to reactive arthritis

Symptoms for Reactive Arthritis

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50Orphanet
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Symptoms:

50 (show all 28)
  • enanthema/aphtosa/aphta/leukoplakia
  • cartilage destruction/chondrolysis
  • pustula/pustulosis
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • fever/chilling
  • dysplastic/thick/grooved fingernails
  • urethral anomalies/stenosis/posterior urethral valves/megalocystis
  • inflammatory intestinal disease
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • lung fibrosis
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • photophobia
  • restricted joint mobility/joint stiffness/ankylosis
  • malabsorption/chronic diarrhea/steatorrhea
  • arthritis/synovitis/synovial proliferation
  • nails anomalies
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • recurrent urinary infections
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Reactive Arthritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reactive Arthritis

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Anatomical Context for Reactive Arthritis

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34MalaCards
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MalaCards organs/tissues related to Reactive Arthritis:

34
Eye, T cells, Lung, Bone, B cells, Skin, Heart, Tonsil, Whole blood, Testes, Spinal cord, Liver, Monocytes, Breast, Nk cells, Endothelial

Animal Models for Reactive Arthritis or affiliated genes

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Publications for Reactive Arthritis

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53PubMed
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Articles related to Reactive Arthritis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
High frequency of reactive arthritis in adults after Yersinia pseudotuberculosis O:1 outbreak caused by contaminated grated carrots. (23852698)
2013
2
TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis. (23207279)
2013
3
Methicillin-resistant Staphylococcus aureus induced reactive arthritis treated with systemic corticosteroid. (23492683)
2013
4
The role of Chlamydia and Chlamydophila infections in reactive arthritis. (22214635)
2012
5
Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland. (21679096)
2011
6
Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy. (21181220)
2011
7
The evolving story of Chlamydia-induced reactive arthritis. (20445454)
2010
8
Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. (20155838)
2010
9
Reactive arthritis due to Clostridium difficile. (20171133)
2010
10
Live polio vaccine exposure while receiving anti-TNF therapy for reactive arthritis. (20536606)
2010
11
Detection and frequency of Chlamydia trachomatis DNA in synovial samples from Tunisian patients with reactive arthritis and undifferentiated oligoarthritis. (19159429)
2009
12
Reactive arthritis associated with hidradenitis suppurativa. (19397229)
2009
13
Reactive arthritis associated with L2b lymphogranuloma venereum proctitis. (19478106)
2009
14
Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis in Tunisia. (19152094)
2009
15
Toll-like receptor 2 variants are associated with acute reactive arthritis. (18975326)
2008
16
Antibacterial antibodies for some enterobacteria in sera of patients with reactive arthritis and other rheumatoid diseases. (19284164)
2008
17
Frequency of recent parvovirus infection in patients examined for acute reactive arthritis. A study with combinatorial parvovirus serodiagnostics. (17543157)
2007
18
Clinical presentations of chlamydial and non-chlamydial reactive arthritis. (16432687)
2006
19
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. (15878901)
2005
20
Human immunodeficiency virus related reactive arthritis in Zambia. (15996068)
2005
21
Cellular and humoral markers of systemic inflammation in acute reactive arthritis and early rheumatoid arthritis. (15124937)
2004
22
Management of sexually acquired reactive arthritis in 19 North Thames GUM clinics. (15038868)
2004
23
Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. (14739472)
2004
24
Unusual causes of reactive arthritis: Leptospira and Coxiella burnetii. (14576997)
2003
25
Yersinia enterocolitica O:3 isolated from patients with or without reactive arthritis induces polyclonal activation of B cells and autoantibody production in vivo. (14567555)
2003
26
Chlamydial conjunctivitis (in adults), uveitis, and reactive arthritis, including SARA. Sexually acquired reactive arthritis. (12473284)
2002
27
Bacteria-Triggered reactive arthritis: implications for antibacterial treatment. (11293645)
2001
28
European guideline for the management of sexually acquired reactive arthritis. (11589806)
2001
29
Diagnostic evaluation of classification criteria for RA and reactive arthritis. (10836957)
2000
30
Management of reactive arthritis in a juvenile gorilla (Gorilla gorilla gorilla) with long-term sulfasalazine therapy. (11428403)
2000
31
Index of suspicion. Case #1. Diagnosis: Nongroup A poststreptococcal reactive arthritis. (11041668)
2000
32
Ciprofloxacin v placebo for treatment of Yersinia enterocolitica triggered reactive arthritis. (11053072)
2000
33
Pathogenesis of reactive arthritis. (10225663)
1999
34
Recurrent reactive arthritis associated with urinary tract infection by Escherichia coli. (10529156)
1999
35
Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Heat-shock protein 60 drives a major immune response. (9485090)
1998
36
Detection of Chlamydia trachomatis in peripheral blood leukocytes of reactive arthritis patients by polymerase chain reaction. (9778233)
1998
37
Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? (9640127)
1998
38
Reactive arthritis in a patient with simultaneous parvovirus B19 infection and Clostridium difficile diarrhoea. (9117160)
1997
39
Characterization of serum antibody response to chlamydiae in patients with sexually acquired reactive arthritis. (9453389)
1997
40
Comment on the article 'Reactive arthritis, beta-haemolytic Streptococcus and Staphylococcus aureus' by D. N. Leitch and C. D. Holland. (9189069)
1997
41
Cross-reactivity between Borrelia burgdorferi and "arthrogenic" bacteria in sera from patients with reactive arthritis. (8673811)
1996
42
Reactive arthritis after an insect bite--suspect the unsuspected. (8609869)
1996
43
Antigen-presenting cells but not lymphocytes in the joint may indicate the cause of reactive arthritis. (8948293)
1996
44
Poststreptococcal reactive arthritis, clinical course, and outcome in 6 adult patients. (8523350)
1995
45
Fast food arthritis--a clinico-pathologic study of post-Salmonella reactive arthritis. (8991996)
1995
46
Reactive arthritis following Clostridium difficile colitis. (7863666)
1995
47
Poststreptococcal reactive arthritis mimicking acute septic arthritis: a hospital-based study. (7593582)
1995
48
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. (7923879)
1994
49
Hepatitis B immunisation and reactive arthritis. (7804071)
1994
50
Salmonella-specific antibodies in reactive arthritis. (1955713)
1991

Variations for Reactive Arthritis

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Expression for genes affiliated with Reactive Arthritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reactive Arthritis

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Pathways for genes affiliated with Reactive Arthritis

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Compounds for genes affiliated with Reactive Arthritis

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Reactive Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1urea46 25 1211.6BPI, MMP8
2endotoxin469.3BPI, CXCL5
3fmlp469.1BPI, CXCL5
4vegf469.0MMP8, CXCL5, BPI
5zinc46 259.9SLC11A1, CXCL5, MMP8, OMP
6calcium46 52 25 1211.7SLC11A1, CXCL5, MMP8, OMP
7nitric oxide46 25 1210.7MMP8, CXCL5, BPI, SLC11A1

GO Terms for genes affiliated with Reactive Arthritis

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17Gene Ontology
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Biological processes related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.5SLC11A1, BPI
2immune responseGO:0069558.5IL21, BPI, CXCL5

Products for genes affiliated with Reactive Arthritis

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  • Antibodies
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  • Lysates
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Sources for Reactive Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet