PIRA
MCID: RCT015
MIFTS: 62

Reactive Arthritis (PIRA) malady

Bone diseases, Gastrointestinal diseases categories

Summaries for Reactive Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. this process may occur weeks or even months after the infection has resolved. in addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). these symptoms may occur alone, together, or not at all. the symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. the exact cause of reactive arthritis is unknown. it may follow an infection with salmonella enteritidis, salmonella typhimurium, yersinia enterocolitica, campylobacter jejuni, clostridium difficile, shigella sonnei, entamoeba histolytica, cryptosporidium, or chlamydia trachomatis. certain genes may make you more prone to the syndrome. for instance, the condition is observed more commonly in patients with human lymphocyte antigen b27 (hla-b27) histocompatibility antigens. the goal of treatment is to relieve symptoms and treat any underlying infection. antibiotics may be prescribed. nonsteroidal anti-inflammatory drugs (nsaids), pain relievers, and corticosteroids may be recommended for those with joint pain.  last updated: 3/31/2012

MalaCards: Reactive Arthritis, also known as reiter syndrome, is related to arthritis and rheumatoid arthritis, and has symptoms including recurrent urinary infections, tendon rupture/tendinitis/bursitis/tenosynovitis and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Reactive Arthritis is OMP (olfactory marker protein), and among its related pathways are Chemokine receptors bind chemokines and Chemokine Signaling. The compounds ccl3 and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and lung.

Disease Ontology:8 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia:63 Reactive arthritis is classified as an autoimmune condition that develops in response to an infection in... more...

Aliases & Classifications for Reactive Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
reactive arthritis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

reactive arthritis 8 42 10 48
reiter syndrome 42 48 60
post-infectious reactive arthropathy 42
fiessinger-leroy-reiter syndrome 48
fiessinger leroy reiter syndrome 8
post-dysenteric arthropathy 60
post-bacterial arthropathy 8
postdysenteric arthropathy 8
post-infectious arthritis 42
fiessinger-leroy disease 48
polyarteritis enterica 48
arthritis urethritica 48
arthritis, reactive 60
arthritis, venereal 60
arthritis reactive 44
venereal arthritis 48
reiter's syndrome 42
reiters syndrome 44
reiter's disease 8
reiter disease 8
pira 42


External Ids:

Disease Ontology8 DOID:6196
ICD9CM27 099.3
NCIt39 C34975
MeSH34 D016918
UMLS via Orphanet61 C0085435, C0035012
MESH via Orphanet35 D016918
ICD10 via Orphanet26 M02.8
SNOMED-CT via Orphanet57 129133005, 236690002, 239783001 67224007, more
ICD1025 M02.1, M02.3

Related Diseases for Reactive Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.9SLC11A1, COMP, CCR1, S100A12, MRAP, CXCL5
2rheumatoid arthritis30.9COMP, CCR1, S100A12, CXCL5, IL21, IL17A
3psoriatic arthritis30.5MRAP
4osteoarthritis30.4COMP, CXCL5, IL21, IL17A, MMP8, CEACAM8
5vasculitis30.2IL17A, S100A12
6synovitis30.1COMP, IL17A, MMP8
7keratitis30.1IL17A
8meningitis29.9OMP
9inflammatory bowel disease29.9MRAP, S100A12
10ulcerative colitis29.9CXCL5, IL21, IL17A, SLC11A1
11psoriasis29.9IL17A, MRAP, S100A12
12ankylosing spondylitis10.5
13spondylitis10.5
14rheumatic fever10.4
15septic arthritis10.4
16spondyloarthropathy10.4
17gastroenteritis10.3
18pneumonia10.3
19uveitis10.3
20urethritis10.3
21conjunctivitis10.2
22tuberculosis10.2
23bladder carcinoma10.2
24tetanus10.2
25proctitis10.1
26systemic lupus erythematosus10.1
27pharyngitis10.1
28hidradenitis suppurativa10.1
29tonsillitis10.1
30cervicitis10.1
31diarrhea10.1
32glomerulonephritis10.1
33hidradenitis10.1
34lupus erythematosus10.1
35choroiditis10.0
36urethral syndrome10.0
37hypersensitivity reaction type ii disease10.0IL17A, TRH
38sarcoidosis10.0CXCL5, SLC11A1
39malaria10.0SLC11A1
40leukemia10.0IL17A, CCR1
41leishmaniasis10.0SLC11A1
42atherosclerosis10.0COMP, CCL15, IL17A, MMP8
43periodontitis10.0MMP8, IL17A, OMP
44funisitis10.0MMP8
45cork-handlers' disease10.0CXCL5, IL17A, MMP8, SLC11A1
46obesity10.0IL17A, TRH, COMP
47neisseria meningitidis infection10.0ROM1, OMP
48multiple sclerosis10.0CCR1, IL17A, MMP8, SLC11A1
49peritonitis10.0MMP8
50asthma10.0CCR1, S100A12, CXCL5, IL17A, MMP8, SLC11A1

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to reactive arthritis

Clinical Features for Reactive Arthritis

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48Orphanet
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Symptoms:

48 (show all 28)
  • recurrent urinary infections
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • dysplastic/thick/grooved fingernails
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • urethral anomalies/stenosis/posterior urethral valves/megalocystis
  • malabsorption/chronic diarrhea/steatorrhea
  • nails anomalies
  • enanthema/aphtosa/aphta/leukoplakia
  • pustula/pustulosis
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lung fibrosis
  • photophobia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • inflammatory intestinal disease
  • acute abdominal pain/colic
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • cartilage destruction/chondrolysis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Reactive Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reactive Arthritis

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Anatomical Context for Reactive Arthritis

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32MalaCards
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MalaCards organs/tissues related to Reactive Arthritis:

32
T cells, Eye, Lung, Bone, B cells, Skin, Testes, Heart, Monocytes, Tonsil, Whole blood, Spinal cord, Endothelial, Kidney, Liver, Breast, Nk cells

Animal Models for Reactive Arthritis or affiliated genes

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Publications for Reactive Arthritis

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50PubMed
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Articles related to Reactive Arthritis:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Bilateral retinal detachment in reactive arthritis: coincidence or association? (22198118)
2012
2
Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever. (22013970)
2011
3
Combination treatment in Chlamydia-triggered reactive arthritis: comment on the article by Carter et al. (20936631)
2011
4
Keratitis in reactive arthritis (Reiter syndrome) in childhood. (21738103)
2011
5
The evolving story of Chlamydia-induced reactive arthritis. (20445454)
2010
6
Erythrocyte sedimentation rate, C-reactive protein, or rheumatoid factor are normal at presentation in 35%-45% of patients with rheumatoid arthritis seen between 1980 and 2004: analyses from Finland and the United States. (19411389)
2009
7
Reactive arthritis associated with L2b lymphogranuloma venereum proctitis. (19478106)
2009
8
High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion. (19447929)
2009
9
Images in clinical tropical medicine: Reactive arthritis (Poncet's disease) and erythema nodosum accompanying tuberculosis. (19346365)
2009
10
Ankylosing spondylitis and reactive arthritis in the developing world. (18783746)
2008
11
Co-occurrence of poststreptococcal reactive arthritis and acute glomerulonephritis. (18548195)
2008
12
C-reactive protein: the underlying cause of microvascular dysfunction in rheumatoid arthritis. (18854346)
2008
13
Reactive arthritis of the temporomandibular joints and cervical spine in a child. (17550629)
2007
14
Study of predominant bacterial antigens triggering antibody response in Salmonella reactive arthritis: apropos of a case. (17642539)
2007
15
Coexistence of osteopoikilosis with reactive arthritis: a case report. (16187060)
2006
16
Treatment of reactive arthritis with azithromycin. (15918991)
2005
17
Management of sexually acquired reactive arthritis in 19 North Thames GUM clinics. (15038868)
2004
18
Nonspecific urethritis and reactive arthritis. (15596317)
2004
19
Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amyloidosis. (14613268)
2003
20
Unusual causes of reactive arthritis: Leptospira and Coxiella burnetii. (14576997)
2003
21
Effect of a three month course of ciprofloxacin on the late prognosis of reactive arthritis. (12922963)
2003
22
Reactive arthritis after an outbreak of Yersinia pseudotuberculosis serotype O:3 infection. (12922960)
2003
23
CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. (12975472)
2003
24
Reactive arthritis associated with prolonged cryptosporidial infection. (12860157)
2003
25
Reactive arthritis induced by Gardnerella vaginalis. (12412212)
2002
26
Combined antibiotic therapy of post-venereal reactive arthritis. (17041374)
2002
27
Two years of penicillin prophylaxis is sufficient to prevent clinically evident carditis in poststreptococcal reactive arthritis. (11887981)
2001
28
Male sex predominance in Chlamydia trachomatis sexually acquired reactive arthritis: are women more protected by anti-chlamydia antibodies? (11350850)
2001
29
Reactive arthritis. (11574987)
2001
30
Indirect evidence of intra-articular immunoglobulin G synthesis in patients with Chlamydia trachomatis reactive arthritis. (11477285)
2001
31
Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. (10708808)
2000
32
Reactive arthritis associated with typhoid vaccination in travelers: report of two cases with negative HLA-B27. (10689239)
2000
33
Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. (10640771)
2000
34
Report on the Fourth International Workshop on Reactive Arthritis. (10765916)
2000
35
Analysis of the antigen-specific T cell response in reactive arthritis by flow cytometry. (11145043)
2000
36
Post-streptococcal reactive arthritis: a clinical and serological description, revealing its distinction from acute rheumatic fever. (10205588)
1999
37
Persistent or severe course of reactive arthritis following Salmonella enteritidis infection. A prospective study of 9 cases. (9855213)
1998
38
Bacteria-specific lymphocyte proliferation in peripheral blood in reactive arthritis and related diseases. (9651079)
1998
39
Longitudinal investigation of bacterium-specific synovial lymphocyte proliferation in reactive arthritis and lyme arthritis. (9714358)
1998
40
Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in patients with rheumatoid arthritis. (9263138)
1997
41
Sulfasalazine and human immunodeficiency virus-associated reactive arthritis: comment on the article by Clegg et al. (9336436)
1997
42
Reactive arthritis. (9229179)
1997
43
The early diagnosis of reactive arthritis. (8959919)
1996
44
Reactive arthritis induced by tonsillitis. (9082784)
1996
45
Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome). A Department of Veterans Affairs Cooperative Study. (8961907)
1996
46
Change in the epidemiology of Reiter's syndrome (reactive arthritis) in the post-AIDS era? An analysis of cases appearing in the Greek Army. (7738947)
1995
47
Reactive arthritis ascribed to Chlamydia pneumoniae. Report of a case. (7788343)
1995
48
Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. (7883993)
1995
49
TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. (8770637)
1995
50
IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis. (1316199)
1992

Genetic Variations for Reactive Arthritis

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Expression for genes affiliated with Reactive Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reactive Arthritis

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Pathways for genes affiliated with Reactive Arthritis

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Sources:
53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Reactive Arthritis

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44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ccl344 2811.4CCL16, CCL15, CCR1, CXCL5
2ccl444 2811.4IL17A, CXCL5, CCR1, CCL15
3glycosaminoglycan4410.4COMP, CCR1, MMP8
4rantes4410.4IL17A, CXCL5, CCR1, CCL14, CCL16
5p0024410.4MMP8, IL17A, COMP
6pge24410.3MMP8, IL17A, CXCL5, CCR1
7oligonucleotide4410.3COMP, S100A12, TRH, CXCL5, IL17A, MMP8
8zinc44 2411.2S100A12, OMP, CXCL5, MMP8, SLC11A1
9nitric oxide44 11 2412.1SLC11A1, MMP8, IL17A, CXCL5, CCR1
10calcium44 49 11 2413.0CCL15, CCL16, COMP, KLRB1, CCR1, S100A12
11hydrogen44 2410.9COMP, TRH, MMP8, SLC11A1

GO Terms for genes affiliated with Reactive Arthritis

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16Gene Ontology
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Cellular components related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9CEACAM8, MMP8, IL17A, IL21, CXCL5, CCL15

Biological processes related to Reactive Arthritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive chemotaxisGO:05091810.3CCL15, CCL16
2chemotaxisGO:00693510.3CCL16, CCL15, CCR1, CXCL5
3cell-cell signalingGO:00726710.2CCL16, CCL15, CCR1, TRH, CXCL5, IL17A
4cellular calcium ion homeostasisGO:00687410.2CCL14, CCL15, CCR1
5inflammatory responseGO:00695410.2SLC11A1, IL17A, S100A12, CCR1, CCL16
6immune responseGO:00695510.2CEACAM8, CCL16, CCL14, CCL15, CCR1, CXCL5
7positive regulation of osteoclast differentiationGO:04567210.1IL17A, CCR1

Molecular functions related to Reactive Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.3CCL15, CCL16
2chemokine activityGO:0080099.9CXCL5, CCL15, CCL14, CCL16

Products for genes affiliated with Reactive Arthritis

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Sources for Reactive Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet