Aliases & Classifications for Rectal Disease

MalaCards integrated aliases for Rectal Disease:

Name: Rectal Disease 12 14
Rectal Diseases 41 69
Rectal Disorders 40

Classifications:



External Ids:

Disease Ontology 12 DOID:1285
MeSH 41 D012002
SNOMED-CT 64 5964004
UMLS 69 C0034882

Summaries for Rectal Disease

MedlinePlus : 40 The rectum is the lower part of your large intestine where your body stores stool. Problems with rectum are common. They include hemorrhoids, abscesses, incontinence and cancer. Many people are embarrassed to talk about rectal troubles. But seeing your doctor about problems in this area is important. This is especially true if you have pain or bleeding. Treatments vary depending on the particular problem. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Rectal Disease, also known as rectal diseases, is related to hemorrhoid and proctitis, and has symptoms including gastrointestinal gas, rectal tenesmus and rectal pain. An important gene associated with Rectal Disease is KIDINS220 (Kinase D Interacting Substrate 220). The drugs Aspirin and Diltiazem have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes.

Related Diseases for Rectal Disease

Diseases related to Rectal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 11.2
2 proctitis 10.8
3 anal fistula 10.3 AHSP KIDINS220
4 urethral diverticulum 10.2 KIDINS220 KLK3
5 anus disease 10.2 CLP1 KATNB1
6 neurogenic bowel 10.2 DCXR KIDINS220
7 paraphimosis 10.1 KANTR KLK3
8 urethral syndrome 10.1 KIDINS220 KLK3
9 factitious disorder 10.0 DCXR KANTR
10 radiation cystitis 10.0 KANTR KLK3
11 coronary artery aneurysm 10.0 AHSP KLK3
12 blood group, i system 9.5
13 aging 9.5
14 lymphoma 9.5
15 prostatitis 9.5
16 prostate disease 9.5
17 plasmablastic lymphoma 9.5

Graphical network of the top 20 diseases related to Rectal Disease:



Diseases related to Rectal Disease

Symptoms & Phenotypes for Rectal Disease

UMLS symptoms related to Rectal Disease:


gastrointestinal gas, rectal tenesmus, rectal pain, pruritus ani, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain

Drugs & Therapeutics for Rectal Disease

Drugs for Rectal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 802)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
2
Diltiazem Approved, Investigational Phase 4,Phase 3,Phase 1 42399-41-7 39186
3
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
4
Ethiodized oil Approved, Investigational Phase 4,Phase 2 8008-53-5
5
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
6
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
7
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2 114-07-8 12560
8
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
9
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
10
Tegafur Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
11
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
12
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
13
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
14
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
15
Bisacodyl Approved Phase 4,Phase 3,Phase 2 603-50-9
16
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
17
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 38396-39-3, 2180-92-9 2474
18
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
19
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1 7553-56-2 807
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
21
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
22
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
23 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 329-65-7
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-23-7 657311 5754
25
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
26
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
27
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
28
Celecoxib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 169590-42-5 2662
29
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
30
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3 56-81-5 753
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
32
Zinc Approved, Investigational Phase 4,Phase 1,Phase 2 7440-66-6 32051 23994
33
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
34
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
35
Sucralfate Approved Phase 4 54182-58-0 0
36
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
37
Ketamine Approved, Vet_approved Phase 4,Early Phase 1 6740-88-1 3821
38
Diclofenac Approved, Vet_approved Phase 4,Phase 2 15307-86-5 3033
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 437-38-7 3345
40
Prilocaine Approved Phase 4,Phase 3 721-50-6 4906
41 Magnesium citrate Approved Phase 4,Phase 3
42
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
43
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
44
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
45
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
46
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 9579578 4594
47
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
48
Darbepoetin alfa Approved, Investigational Phase 4 209810-58-2, 11096-26-7
49
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 175805 71273
50
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 4209)

# Name Status NCT ID Phase Drugs
1 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
2 Pediatrics Anal Fissures Treatment With Polyethylene Glycol Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
3 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
4 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
5 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
6 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
7 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
8 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
9 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
10 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
11 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
12 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
13 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
14 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
15 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
16 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy Unknown status NCT01099605 Phase 4
17 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
18 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
19 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
20 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
21 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
22 Polyacrylamide Hydrogel Injection Treatment for Anal Incontinence Completed NCT02550899 Phase 4
23 Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure Completed NCT00827736 Phase 4 ISDN ointment;Placebo
24 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
25 Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis Completed NCT01124149 Phase 4 MMX mesalamine/ mesalazine
26 Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids Completed NCT02046772 Phase 4 Bupivacaine low dose;Bupivacaine standard dose;Morphine Chloride
27 A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4 Carraghenates Cream;Mayinglong Musk Hemorrhoid Ointment
28 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4 Bupivacaine;Placebo
29 Comparison Between Excisional Hemorrhoidectomy and Haemorrhoidal Dearterialisation With Anopexy Completed NCT01263431 Phase 4
30 Symptom Control 1-year After Circular Stapler Anopexy or Diathermy Excision for Prolapsed Haemorhoids Completed NCT00841620 Phase 4
31 The Safety of Proctofoam-HC in the Third Trimester of Pregnancy Completed NCT00405288 Phase 4 Proctofoam-HC®
32 Effect of Perioperative i.v. Low-dose S(+) Ketamine Completed NCT00354029 Phase 4 S (+) Ketamine;Placebo
33 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
34 Sacral Nerve Stimulation for Anal Incontinence and Bowel Control Completed NCT00200005 Phase 4
35 Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
36 Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
37 Pain Relief for Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
38 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
39 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
40 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
41 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
42 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
43 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
44 Intravenous Iron: Measuring Response in Anemic Surgical Patients Completed NCT02057471 Phase 4 Intravenous ferric carboxymaltose
45 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
46 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
47 Observational Study of Vectibix With Chemotherapy for Metastatic Colorectal Cancer Patients Completed NCT01732783 Phase 4
48 IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia Completed NCT01701310 Phase 4 Ferric carboxymaltose;Ferrous Sulphate
49 Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
50 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab

Search NIH Clinical Center for Rectal Disease

Cochrane evidence based reviews: rectal diseases

Genetic Tests for Rectal Disease

Anatomical Context for Rectal Disease

MalaCards organs/tissues related to Rectal Disease:

38
Liver, Colon, Testes, Lung, Lymph Node, Skin, Prostate

Publications for Rectal Disease

Articles related to Rectal Disease:

(show all 28)
# Title Authors Year
1
Topographic Anatomy of the Anal Sphincter Complex and Levator Ani Muscle as It Relates to Intersphincteric Resection for Very Low Rectal Disease. ( 27050605 )
2016
2
Elastosonography in malignant rectal disease: preliminary data. ( 17427082 )
2007
3
Radiofrequency surgery--novel techniques in the treatment of ano-rectal disease. ( 17139880 )
2006
4
Plasmablastic lymphoma: a case of rectal disease with spinal cord compression. ( 17169819 )
2006
5
Incidental discovery of ano-rectal disease during transrectal ultrasound performed for prostatic disease. ( 15906788 )
2005
6
A new technique of laparoscopic surgery for rectal disease. ( 15098039 )
2004
7
EUS for rectal disease. ( 12085043 )
2002
8
Use of colostomy to manage rectal disease in dogs. ( 9232784 )
1997
9
Medical malpractice involving colon and rectal disease. ( 8287753 )
1994
10
Medical malpractice involving colon and rectal disease: a 20-year review of United States civil court litigation. ( 8500369 )
1993
11
Endoscopic ultrasonography in the evaluation of colon and rectal disease. ( 2184084 )
1990
12
Colon and rectal disease 1947-1987. ( 3313352 )
1987
13
Coloanal anastomosis in the management of benign and malignant rectal disease. ( 3675022 )
1987
14
Lord's rectal dilitation and treatment of rectal disease. ( 3998626 )
1985
15
The effects on pelvic visceral function of anal sphincter ablating and anal sphincter preserving operations for cancer of the lower part of the rectum and for benign colo-rectal disease. ( 6691700 )
1984
16
Colonoscopic retroflexion in the evaluation of rectal disease. ( 7137139 )
1982
17
The prone cross-table lateral view of the rectum: a useful projection in the evaluation of rectal disease. ( 7165608 )
1982
18
Rectal disease in a patient with delirium tremens. ( 7365944 )
1980
19
The role of fiberoptic colonoscopy in the diagnosis of colonic and rectal disease. ( 4746166 )
1973
20
Investigation of colonic and rectal disease. Arteriography. ( 4642021 )
1972
21
Symposium on canine recto-anal disorders--II: The surgical pathology of ano-rectal disease in the dog. ( 5691229 )
1968
22
Colonic and rectal disease in the young adult. ( 13975128 )
1962
23
Relation of ano-rectal disease to carcinoma; with special reference to hemorrhoids. ( 13340006 )
1956
24
Recent advances in the surgical treatment of colon and rectal disease. ( 18152700 )
1949
25
Ano-rectal disease; incidence in 300 males of military age with particular reference to polyposis. ( 18108281 )
1949
26
Treatment of patients with rectal disease. ( 20248643 )
1947
27
LOCAL ANAESTHESIA IN ANO-RECTAL DISEASE. ( 20321127 )
1938
28
Remarks on Two Cases of Rectal Disease Treated by Modified Operative Methods. ( 20755289 )
1895

Variations for Rectal Disease

Expression for Rectal Disease

Search GEO for disease gene expression data for Rectal Disease.

Pathways for Rectal Disease

GO Terms for Rectal Disease

Sources for Rectal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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