Aliases & Classifications for Rectal Neoplasm

MalaCards integrated aliases for Rectal Neoplasm:

Name: Rectal Neoplasm 12 72 14
Rectal Carcinoma 51 69
Rectal Neoplasms 41 69
Rectum Cancer 12 14
Rectal Cancer 12 51
Malignant Neoplasm of Rectum 12
Malignant Tumor of Rectum 12
Malignant Rectal Neoplasm 69
Adenocarcinoma of Rectum 69
Carcinoma of the Rectum 12
Malignant Rectal Tumor 12
Malignant Rectum Tumor 12
Neoplasm of the Rectum 28
Carcinoma of Rectum 12
Neoplasm of Rectum 12
Cancer of Rectum 12
Rectum Neoplasm 12
Rectal Tumors 69
Rectal Tumor 12

Classifications:



Summaries for Rectal Neoplasm

Disease Ontology : 12 A colorectal cancer that is located in the rectum.

MalaCards based summary : Rectal Neoplasm, also known as rectal carcinoma, is related to rectum adenocarcinoma and lynch syndrome. An important gene associated with Rectal Neoplasm is TYMS (Thymidylate Synthetase), and among its related pathways/superpathways are Pathways in cancer and DNA Damage. The drugs Erbitux and Iron have been mentioned in the context of this disorder. Affiliated tissues include the rectum, colon and liver, and related phenotype is neoplasm.

Wikipedia : 72 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Rectal Neoplasm

Diseases related to Rectal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 rectum adenocarcinoma 31.8 CEACAM5 KRT20 KRT7 SLC14A2
2 lynch syndrome 31.8 KRAS MLH1 MSH2 TP53
3 colorectal cancer 29.8 CEACAM5 DPYD HRAS KRAS KRT20 KRT7
4 adenoma 29.7 KRAS KRT7 MLH1 MSH2 TP53
5 rectal cancer, childhood 12.0
6 rectum sarcoma 11.0
7 mucoepidermoid esophageal carcinoma 10.6 CEACAM5 TP53
8 intracranial chondrosarcoma 10.6 CEACAM5 TP53
9 cystic basal cell carcinoma 10.6 KRT20 KRT7
10 appendix carcinoid tumor 10.6 MLH1 MSH2
11 adenosquamous colon carcinoma 10.6 MLH1 MSH2
12 lymphomatous meningitis 10.6 CEACAM5 TYMP
13 cutaneous mucoepidermoid carcinoma 10.6 CEACAM5 KRT7
14 anal gland adenocarcinoma 10.6 CEACAM5 KRT7
15 liver lymphoma 10.5 CEACAM5 SMUG1
16 lung acinar adenocarcinoma 10.5 KRT20 KRT7
17 anus adenocarcinoma 10.5 CEACAM5 KRT7
18 gallbladder squamous cell carcinoma 10.5 CEACAM5 SMUG1
19 splenic tuberculosis 10.5 CEACAM5 SMUG1
20 vaginal benign neoplasm 10.5 KRT20 KRT7
21 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
22 periampullary adenoma 10.5 HRAS KRAS
23 transverse colon cancer 10.5 KRT20 KRT7
24 ovarian large-cell neuroendocrine carcinoma 10.5 KRT20 KRT7
25 vaginal adenoma 10.5 KRT20 KRT7
26 vaginal tubulovillous adenoma 10.5 KRT20 KRT7
27 actinic cheilitis 10.5 MSH2 TP53
28 schimmelpenning-feuerstein-mims syndrome 10.5 HRAS KRAS
29 sigmoid neoplasm 10.5 CEACAM5 HRAS KRAS
30 apocrine adenoma 10.5 CEACAM5 HRAS KRAS
31 mucinous adenofibroma 10.5 CEACAM5 KRT7
32 aggressive digital papillary adenocarcinoma 10.5 CEACAM5 HRAS KRAS
33 sebaceous adenoma 10.5 MLH1 MSH2
34 microinvasive gastric cancer 10.5 CEACAM5 MLH1 TYMP
35 eyelid neoplasm 10.5 KRT20 KRT7
36 ovary serous adenocarcinoma 10.5 CEACAM5 HRAS KRAS
37 ovarian cystadenocarcinoma 10.5 CEACAM5 HRAS KRAS
38 vulval paget's disease 10.5 CEACAM5 KRT20 KRT7
39 bile duct cystadenocarcinoma 10.5 CEACAM5 KRT20 KRT7
40 thymus adenocarcinoma 10.5 CEACAM5 KRT20 KRT7
41 bartholin's duct cyst 10.5 SMUG1 TP53
42 meibomian cyst 10.5 CEACAM5 KRT20 KRT7
43 appendix cancer 10.5 KRAS KRT20 KRT7
44 cutaneous adenocystic carcinoma 10.5 CEACAM5 KRT7
45 vulva adenocarcinoma 10.5 CEACAM5 KRT20 KRT7
46 lower lip cancer 10.5 MLH1 MSH2
47 benign mesothelioma 10.5 KRT20 KRT7 TYMS
48 malignant syringoma 10.5 KRT20 KRT7
49 infiltrative basal cell carcinoma 10.5 CEACAM5 KRT20 KRT7
50 adenocarcinoma in situ 10.5 KRAS KRT20 KRT7

Comorbidity relations with Rectal Neoplasm via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Anus Cancer Colorectal Cancer
Deficiency Anemia Hydronephrosis
Intestinal Obstruction Neutropenia
Paralytic Ileus Protein-Energy Malnutrition
Rectosigmoid Junction Neoplasm Rectum Carcinoma in Situ

Graphical network of the top 20 diseases related to Rectal Neoplasm:



Diseases related to Rectal Neoplasm

Symptoms & Phenotypes for Rectal Neoplasm

MGI Mouse Phenotypes related to Rectal Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 APAF1 HRAS KRAS MLH1 MMP7 MSH2

Drugs & Therapeutics for Rectal Neoplasm

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Erbitux 17 45 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004

Drugs for Rectal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 378)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
3
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
4
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Menthol Approved Phase 4,Phase 2,Phase 1 2216-51-5 16666
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
9
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
14
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
15
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Methadone Approved Phase 4 76-99-3 4095
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Orphenadrine Approved Phase 4 83-98-7 4601
21
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
22
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
23
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
24 Ferric Compounds Phase 4
25 Ferric oxide, saccharated Phase 4
26 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
27 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Cathartics Phase 4
30 Laxatives Phase 4
31 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
32 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2
33 Phosphodiesterase Inhibitors Phase 4,Phase 2
34 Sildenafil Citrate Phase 4 171599-83-0
35 Vasodilator Agents Phase 4,Phase 1,Phase 2
36 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Adjuvants, Anesthesia Phase 4
39 Adrenergic Agents Phase 4,Phase 3
40 Adrenergic Agonists Phase 4
41 Adrenergic alpha-2 Receptor Agonists Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Analgesics Phase 4,Phase 2,Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
45 Analgesics, Opioid Phase 4
46 Anesthetics, General Phase 4
47 Anesthetics, Intravenous Phase 4
48 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
49 Hypnotics and Sedatives Phase 4,Phase 1,Phase 2
50 Narcotics Phase 4

Interventional clinical trials:

(show top 50) (show all 879)

# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4 polyethylene glycol
3 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
4 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4 Ertapenem
5 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
6 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
7 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
8 The Effect of Dexmedetomidine on Postoperative Analgesia Completed NCT01373021 Phase 4 Fentanyl;Dexmedetomidine
9 Prospective Randomized Study of SILS Versus CLS for Rectal Cancer Completed NCT01579721 Phase 4
10 CHOICE: Communicating Health Options Through Information and Cancer Education Completed NCT00134589 Phase 4
11 Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas Recruiting NCT01023984 Phase 4
12 Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
13 Study of NOTES-TME Versus L-LAR in Rectal Cancer Recruiting NCT02550769 Phase 4
14 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
15 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery Unknown status NCT02598414 Phase 2, Phase 3
16 Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer Unknown status NCT02127645 Phase 3
17 Randomized Controlled Trial to Evaluate High Tie Versus Low Tie of the Inferior Mesenteric Artery in Anterior Resection Unknown status NCT01861678 Phase 3
18 Short Term Outcomes of Laparoscopic Intersphincteric Resection for Low Rectal Cancer Unknown status NCT01836926 Phase 2, Phase 3
19 Preoperative Downstaging of Extraperitoneal T3 Rectal Cancer: XELOXRT Versus XELACRT. A Multicenter, Phase III Study Unknown status NCT01653301 Phase 3 XELAC RT;XELOX RT
20 VSL#3 Versus Placebo in Increasing the Pathological Major Response Rate in Patients With Rectal Cancer Unknown status NCT01579591 Phase 3
21 Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer Unknown status NCT01224392 Phase 3
22 A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Unknown status NCT01064999 Phase 2, Phase 3 Oxaliplatin;Capecitabine
23 The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer Unknown status NCT00833131 Phase 3
24 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3
25 A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT) Unknown status NCT00601549 Phase 3
26 Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer Unknown status NCT00597311 Phase 3
27 Randomized Prospective Trial for Laparoscopic vs Open Resection for Rectal Cancer Unknown status NCT00470951 Phase 3
28 COLOR II: Laparoscopic Versus Open Rectal Cancer Removal Unknown status NCT00297791 Phase 3
29 5FU/VL Vs LV5FU2 + CPT11 in Stage II-III Resected Rectal Cancer Unknown status NCT00189657 Phase 3
30 Resource-Sparing Curative Treatment for Rectal Cancer Unknown status NCT01459328 Phase 3
31 Randomized Trial on Robotic Assisted Resection for Rectal Cancer Unknown status NCT01130233 Phase 3
32 Partnership for Healthy Seniors Unknown status NCT00379743 Phase 3
33 Concurrent Chemoradiation Versus Wide Pelvic Lymphadenectomy for Advanced Rectal Cancer Unknown status NCT00154752 Phase 3
34 Comparison of Two Types of Surgery in Treating Patients With Rectal Cancer Unknown status NCT00007930 Phase 3
35 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
36 Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy With 5-Fluorouracil and Oxaliplatin Versus 5-Fluorouracil Alone in Rectal Cancer Completed NCT00349076 Phase 3 5-FU and oxaliplatin;5-FU
37 Mesorectal Excision (ME) Versus ME With Lateral Node Dissection for Stage II, III Lower Rectal Cancer (JCOG0212) Completed NCT00190541 Phase 3
38 Capecitabine Versus Bolus 5-Fu Associated to Radiotherapy as Neoadjuvant Treatment for Rectal Cancer. Completed NCT03428529 Phase 2, Phase 3 Capecitabine Oral Product;5Fluorouracil
39 Efficiency of Two Dimensional High Definition Versus Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery Completed NCT01498354 Phase 3
40 Study of the Efficacy and Safety of Epoetin Alfa Administered Weekly in Patients With Gastric or Rectal Cancers Undergoing a Treatment Plan of Preoperative Chemotherapy and Radiation Therapy, Followed by Surgery Completed NCT00036400 Phase 3 epoetin alfa
41 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
42 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
43 Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB Completed NCT00236249 Phase 3 Lidocaine
44 ELRR by TEM Versus Laparoscopic TME in iT2N0M0 SMALL LOW RECTAL CANCER Completed NCT01609504 Phase 3
45 Capecitabine in the Perioperative Treatment of Rectal Cancer Completed NCT01500993 Phase 3 Capecitabine;5-FU
46 Randomized Clinical Trial on Preoperative Radiotherapy 25 Gy in Rectal Cancer Completed NCT01444495 Phase 3
47 Drainage After Rectal Excision for Rectal Cancer Completed NCT01269567 Phase 3
48 Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer Completed NCT01186081 Phase 3
49 Modulation of Adjuvant 5-FU by Folinic Acid and Interferon-alpha in Colon Cancer Completed NCT01060501 Phase 3 Folinic Acid, interferon-alpha
50 Sphincter-preserving Surgery After Preoperative Treatment of Ultra-low Rectal Carcinoma Completed NCT00979680 Phase 3

Search NIH Clinical Center for Rectal Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rectal neoplasms

Genetic Tests for Rectal Neoplasm

Genetic tests related to Rectal Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Rectum 28

Anatomical Context for Rectal Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Rectal Neoplasm:

18
The Rectum

MalaCards organs/tissues related to Rectal Neoplasm:

38
Colon, Liver, Testes, Lymph Node, Lung, Brain, Prostate

Publications for Rectal Neoplasm

Articles related to Rectal Neoplasm:

(show all 15)
# Title Authors Year
1
Pancreatic solid pseudopapillary neoplasm as an incidental discovery in a patient with rectal neoplasm. ( 28338106 )
2017
2
Endoscopic submucosal dissection of an unusual flat rectal neoplasm. ( 25320106 )
2014
3
Hybrid transanal endoscopic microsurgery: a novel approach to rectal neoplasm excision. ( 24118673 )
2013
4
Phantom rectum following abdominoperineal excision for rectal neoplasm: appearance and disappearance. ( 23746116 )
2013
5
Images of the month: heterotopic gastric mucosa mimicking rectal neoplasm on colonoscopy. ( 23552305 )
2013
6
Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. ( 22584407 )
2012
7
Postradiotherapy regression--a prognostic factor in rectal neoplasm. ( 22308912 )
2011
8
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery. ( 21633951 )
2011
9
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery (Br J Surg 2011; 98: 1342-1344). ( 21887781 )
2011
10
Solitary rectal ulcer syndrome mimicking rectal neoplasm on MRI. ( 20965892 )
2010
11
Early outcomes of 100 patients with laparoscopic resection for rectal neoplasm. ( 15931488 )
2004
12
Mass screening for rectal neoplasm in Jiashan County, China. ( 1753269 )
1991
13
Pre-operative staging of rectal neoplasm and its impact on clinical management. ( 4063751 )
1985
14
Granular-cell myoblastoma--an unusual rectal neoplasm. Report of a case. ( 4304580 )
1969
15
Sigmoidorectal prolapse simulating rectal neoplasm. ( 13871441 )
1962

Variations for Rectal Neoplasm

Copy number variations for Rectal Neoplasm from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 139647 2 185171337 185512459 Copy number ZNF804A Rectal cancer
2 166960 3 1109627 1420278 Copy number CNTN6 Rectal cancer
3 225401 7 45400000 54000000 Copy number EGFR Rectal cancer

Expression for Rectal Neoplasm

Search GEO for disease gene expression data for Rectal Neoplasm.

Pathways for Rectal Neoplasm

GO Terms for Rectal Neoplasm

Cellular components related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Rectal Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.63 HRAS KRAS TP53
2 aging GO:0007568 9.62 APAF1 MMP7 TP53 TYMS
3 determination of adult lifespan GO:0008340 9.51 MSH2 TP53
4 response to UV-B GO:0010224 9.49 MSH2 TP53
5 pyrimidine nucleoside catabolic process GO:0046135 9.48 DPYD TYMP
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 MLH1 MSH2
7 response to isolation stress GO:0035900 9.4 HRAS KRAS
8 pyrimidine nucleobase metabolic process GO:0006206 9.37 TYMP TYMS
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MLH1 MSH2
10 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
11 intrinsic apoptotic signaling pathway GO:0097193 9.13 APAF1 HRAS TP53
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Rectal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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