MCID: RCT018
MIFTS: 54

Rectal Neoplasm malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectal Neoplasm

Aliases & Descriptions for Rectal Neoplasm:

Name: Rectal Neoplasm 12 14
Rectal Cancer 12 52 14
Malignant Neoplasm of Rectum 12 29
Rectal Carcinoma 52 69
Rectal Neoplasms 42 69
Rectum Cancer 12 14
Malignant Tumor of Rectum 12
Malignant Rectal Neoplasm 69
Adenocarcinoma of Rectum 69
Carcinoma of the Rectum 12
Malignant Rectal Tumor 12
Malignant Rectum Tumor 12
Carcinoma of Rectum 12
Neoplasm of Rectum 12
Cancer of Rectum 12
Rectum Neoplasm 12
Rectal Tumors 69
Rectal Tumor 12

Classifications:



Summaries for Rectal Neoplasm

Disease Ontology : 12 A colorectal cancer that is located in the rectum.

MalaCards based summary : Rectal Neoplasm, also known as rectal cancer, is related to rectum sarcoma and proctitis. An important gene associated with Rectal Neoplasm is TYMS (Thymidylate Synthetase), and among its related pathways/superpathways are Pathways in cancer and DNA Damage. The drugs Erbitux and Iron have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and endothelial, and related phenotype is neoplasm.

Wikipedia : 71 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Rectal Neoplasm

Diseases related to Rectal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 rectum sarcoma 29.0 APAF1 APBA2 CAGE1 CEACAM5 DPYD HRAS
2 proctitis 29.0 CEACAM5 HRAS KRAS KRT7 MLH1 MMP7
3 colorectal cancer 28.9 CEACAM5 DPYD HRAS KRAS KRT20 KRT7
4 rectal cancer, childhood 11.9
5 lynch syndrome 10.8
6 rectum adenocarcinoma 10.8
7 malignant mediastinal neurogenic neoplasm 10.3 CEACAM5 TP53
8 bladder carcinoma in situ 10.3 CEACAM5 SMUG1
9 malignant skin fibrous histiocytoma 10.3 CEACAM5 HRAS KRAS
10 pulmonary artery choriocarcinoma 10.3 CEACAM5 SMUG1
11 precursor t-lymphoblastic lymphoma/leukemia 10.3 CEACAM5 HRAS KRAS
12 pelvic inflammatory disease 10.3 HRAS KRAS KRT20
13 acute eustachian salpingitis 10.3 CEACAM5 MLH1 TYMP
14 cervical serous adenocarcinoma 10.3 CEACAM5 HRAS KRAS
15 breast mucinous cystadenocarcinoma 10.3 CEACAM5 HRAS KRAS
16 large intestine adenoma 10.3 MLH1 MSH2
17 testis refractory cancer 10.3 CEACAM5 TP53
18 familial hypopituitarism 10.3 MLH1 MSH2 TP53
19 placental site trophoblastic tumor 10.3 KRT20 TP53 TYMP
20 hnrnpa1-related amyotrophic lateral sclerosis 10.3 KRAS MLH1 MSH2
21 inhibited male orgasm 10.3 KRAS SMUG1 TP53
22 familial lipoprotein lipase deficiency 10.3 KRAS SLC14A2 SMUG1
23 ossifying fibromyxoid tumor 10.3 HRAS KRAS TP53
24 aicardi-goutieres syndrome 10.3 HRAS KRAS TP53
25 gonococcal seminal vesiculitis 10.2 HRAS KRAS SMUG1
26 arthus reaction 10.2 HRAS KRAS TP53
27 neurocutaneous melanosis, somatic 10.2 HRAS MLH1 MSH2
28 giant cell tumor 10.2 KRAS KRT20 SLC14A2 TP53
29 chronic monocytic leukemia 10.2 SMUG1 TP53 TYMP
30 radiculopathy 10.2 KRT20 KRT7
31 brachial plexus neuropathy 10.2 HRAS KRAS TP53
32 malignant spindle cell melanoma 10.2 MLH1 MSH2 TP53
33 neuroretinitis 10.2 KRAS KRT20 MLH1 MSH2
34 bulbar polio 10.2 CEACAM5 SMUG1 TP53
35 adult myxoid chondrosarcoma 10.2 KRT20 KRT7
36 prostatic adenoma 10.2 KRAS MLH1 TP53
37 reticulosarcoma 10.2 SMUG1 TP53
38 deep angioma 10.2 CEACAM5 KRT7
39 allergic contact dermatitis 10.2 KRAS KRT20 MLH1 TP53
40 larynx liposarcoma 10.2 MLH1 MSH2 TP53
41 solitary plasmacytoma of chest wall 10.2 CEACAM5 KRT20 MLH1 TYMP
42 tabes dorsalis 10.2 HRAS KRAS KRT20 TP53
43 agenesis and aplasia of uterine body 10.2 KRAS KRT20 KRT7
44 osteosarcoma arising in bone paget's disease 10.2 CEACAM5 KRT7
45 facial dermatosis 10.2 CEACAM5 KRAS MLH1 TP53
46 waterhouse-friderichsen syndrome 10.2 CEACAM5 KRT20 KRT7
47 trophoblastic neoplasm 10.2 CEACAM5 KRT20 KRT7
48 paroxysmal nocturnal hemoglobinuria 10.2 CEACAM5 HRAS KRAS TP53
49 apocrine adenocarcinoma 10.2 CEACAM5 KRT20 KRT7
50 anemia of prematurity 10.2 KRAS KRT20 KRT7

Comorbidity relations with Rectal Neoplasm via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Anus Cancer Colorectal Cancer
Deficiency Anemia Hydronephrosis
Intestinal Obstruction Neutropenia
Paralytic Ileus Protein-Energy Malnutrition
Rectosigmoid Junction Neoplasm Rectum Carcinoma in Situ

Graphical network of the top 20 diseases related to Rectal Neoplasm:



Diseases related to Rectal Neoplasm

Symptoms & Phenotypes for Rectal Neoplasm

MGI Mouse Phenotypes related to Rectal Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 SMUG1 TP53 APAF1 HRAS KRAS MLH1

Drugs & Therapeutics for Rectal Neoplasm

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Erbitux 17 46 CETUXIMAB Imclone, Bristol-Myers Squibb Approved February 2004

Drugs for Rectal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 859)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
2
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
3
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
4 Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
6
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
7
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
8
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
9
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
10
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
11
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 137-58-6 3676
12
Erythromycin Approved, Vet_approved Phase 4,Phase 2 114-07-8 12560
13
Bisacodyl Approved Phase 4,Phase 2 603-50-9
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 437-38-7 3345
15
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
16
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
17
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
18
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
19
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 2078-54-8 4943
20
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
21
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112887-68-0 104758
22
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
24
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
25
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
26
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
27
Finasteride Approved Phase 4 98319-26-7 57363
28
Darbepoetin alfa Approved, Investigational Phase 4 11096-26-7, 209810-58-2
29
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
30
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 443-48-1 4173
31
Sulfamethoxazole Approved Phase 4 723-46-6 5329
32
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
33
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
34
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
35
Sucralfate Approved Phase 4 54182-58-0
36
Sevoflurane Approved, Vet_approved Phase 4,Early Phase 1 28523-86-6 5206
37
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
38
Bupivacaine Approved, Investigational Phase 4,Phase 2 2180-92-9, 38396-39-3 2474
39
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
40
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
41
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
42
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
43
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
44
Zinc Approved Phase 4 7440-66-6 32051 23994
45
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
46
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
47
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
48
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
49
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
50
Methadone Approved Phase 4 76-99-3 4095

Interventional clinical trials:

(show top 50) (show all 3965)
id Name Status NCT ID Phase
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4
2 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4
3 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4
4 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4
5 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4
6 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4
7 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
8 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4
9 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
10 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4
11 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4
12 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
13 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4
14 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4
15 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4
16 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4
17 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4
18 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
19 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4
20 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
21 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4
22 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
23 Prospective Randomized Study of SILS Versus CLS for Rectal Cancer Completed NCT01579721 Phase 4
24 The Effect of Dexmedetomidine on Postoperative Analgesia Completed NCT01373021 Phase 4
25 CHOICE: Communicating Health Options Through Information and Cancer Education Completed NCT00134589 Phase 4
26 3 Month Finasteride Challenge Test Can Significantly Improve the Performance of Screening for Prostate Cancer Completed NCT01296672 Phase 4
27 The Effect of Darbepoetin Upon Rehabilitation for Colorectal Cancer Surgery Completed NCT00122720 Phase 4
28 Study of Biomarkers in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer Completed NCT00559676 Phase 4
29 Orally Administered Trimethoprim-sulfamethoxazole and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery Completed NCT00613769 Phase 4
30 I Phase Surgery Versus Staged Surgery for Synchronous Liver Metastasis of Colorectal Cancer Completed NCT00677586 Phase 4
31 Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants Completed NCT00138060 Phase 4
32 Observational Study of Vectibix With Chemotherapy for Metastatic Colorectal Cancer Patients Completed NCT01732783 Phase 4
33 Dissemination of Colorectal Cancer Screening to Primary Care Physicians Completed NCT00441311 Phase 4
34 Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer Completed NCT00928928 Phase 4
35 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4
36 Benign Prostatic Hyperplasia (BPH) Screening Tool Case Finding Study in Subjects >=50 Years Completed NCT02757963 Phase 4
37 Trial of Patient Navigation-Activation Completed NCT00496678 Phase 4
38 Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles Completed NCT00868816 Phase 4
39 Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
40 Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer Completed NCT00869271 Phase 4
41 Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population Completed NCT01557101 Phase 4
42 Pharmacokinetic Study of Capecitabine in Elderly Cancer Patient (≥ 75 Years) Completed NCT00812864 Phase 4
43 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4
44 A Study of Avastin in Combination With Chemotherapy for Treatment of Colorectal Cancer and Non-Small Cell Lung Cancer (ARIES) Completed NCT00388206 Phase 4
45 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4
46 Preoperative Non-steroidal Anti-inflammatory Drugs(NSAID) to Colorectal Cancer Patients Completed NCT00473980 Phase 4
47 Inflammatory Response in Laparoscopic and Open Colectomy Completed NCT00942461 Phase 4
48 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4
49 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4
50 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4

Search NIH Clinical Center for Rectal Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rectal neoplasms

Genetic Tests for Rectal Neoplasm

Genetic tests related to Rectal Neoplasm:

id Genetic test Affiliating Genes
1 Neoplasm of the Rectum 29

Anatomical Context for Rectal Neoplasm

MalaCards organs/tissues related to Rectal Neoplasm:

39
Colon, Testes, Endothelial, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Rectal Neoplasm:

18
The Rectum

Publications for Rectal Neoplasm

Articles related to Rectal Neoplasm:

(show all 15)
id Title Authors Year
1
Pancreatic solid pseudopapillary neoplasm as an incidental discovery in a patient with rectal neoplasm. ( 28338106 )
2017
2
Endoscopic submucosal dissection of an unusual flat rectal neoplasm. ( 25320106 )
2014
3
Hybrid transanal endoscopic microsurgery: a novel approach to rectal neoplasm excision. ( 24118673 )
2013
4
Phantom rectum following abdominoperineal excision for rectal neoplasm: appearance and disappearance. ( 23746116 )
2013
5
Images of the month: heterotopic gastric mucosa mimicking rectal neoplasm on colonoscopy. ( 23552305 )
2013
6
Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. ( 22584407 )
2012
7
Postradiotherapy regression--a prognostic factor in rectal neoplasm. ( 22308912 )
2011
8
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery (Br J Surg 2011; 98: 1342-1344). ( 21887781 )
2011
9
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery. ( 21633951 )
2011
10
Solitary rectal ulcer syndrome mimicking rectal neoplasm on MRI. ( 20965892 )
2010
11
Early outcomes of 100 patients with laparoscopic resection for rectal neoplasm. ( 15931488 )
2004
12
Mass screening for rectal neoplasm in Jiashan County, China. ( 1753269 )
1991
13
Pre-operative staging of rectal neoplasm and its impact on clinical management. ( 4063751 )
1985
14
Granular-cell myoblastoma--an unusual rectal neoplasm. Report of a case. ( 4304580 )
1969
15
Sigmoidorectal prolapse simulating rectal neoplasm. ( 13871441 )
1962

Variations for Rectal Neoplasm

Copy number variations for Rectal Neoplasm from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 139647 2 185171337 185512459 Copy number ZNF804A Rectal cancer
2 166960 3 1109627 1420278 Copy number CNTN6 Rectal cancer
3 225401 7 45400000 54000000 Copy number EGFR Rectal cancer

Expression for Rectal Neoplasm

Search GEO for disease gene expression data for Rectal Neoplasm.

Pathways for Rectal Neoplasm

Pathways related to Rectal Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1 12.5 HRAS KRAS MLH1 MSH2 TP53
2 12.3 DPYD MLH1 MSH2 TP53 TYMS
3
Show member pathways
12.12 HRAS KRAS MLH1 MSH2 TP53
4
Show member pathways
11.98 APAF1 HRAS KRAS TP53
5 11.88 APAF1 MLH1 MSH2 TP53
6 11.77 KRAS MLH1 MMP7 MSH2 TP53
7
Show member pathways
11.54 APAF1 MMP7 TP53
8 11.53 HRAS KRAS TP53
9 11.51 HRAS KRAS TP53
10 11.49 HRAS KRAS TP53 TYMP
11 11.48 APAF1 KRAS MLH1 MSH2 TP53
12 11.42 APAF1 MLH1 MSH2 TP53
13
Show member pathways
11.26 MLH1 MSH2 TP53
14
Show member pathways
11.15 DPYD SMUG1 TP53 TYMP TYMS
15 11.04 HRAS KRAS TP53
16 10.67 HRAS KRAS

GO Terms for Rectal Neoplasm

Biological processes related to Rectal Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.58 HRAS KRAS TP53
2 determination of adult lifespan GO:0008340 9.48 MSH2 TP53
3 pyrimidine nucleoside catabolic process GO:0046135 9.46 DPYD TYMP
4 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 MLH1 MSH2
5 response to isolation stress GO:0035900 9.37 HRAS KRAS
6 pyrimidine nucleobase metabolic process GO:0006206 9.32 TYMP TYMS
7 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MLH1 MSH2
8 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
9 intrinsic apoptotic signaling pathway GO:0097193 9.13 APAF1 HRAS TP53
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Rectal Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Rectal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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