MCID: RCT011
MIFTS: 42

Rectal Prolapse malady

Gastrointestinal diseases category

Summaries for Rectal Prolapse

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63Wikipedia, 32MalaCards
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Wikipedia:63 Rectal prolapse (rectal procidentia) refers to a medical condition where a section of the wall of the... more...

MalaCards: Rectal Prolapse, also known as procidentia, rectum, is related to intestinal obstruction and intussusception. An important gene associated with Rectal Prolapse is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways is Elastic fibre formation. The compounds trichloroacetic acid and triamcinolone acetonide have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and small intestine, and related mouse phenotypes are normal and respiratory system.

Aliases & Classifications for Rectal Prolapse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

rectal prolapse 8 10 44 60
procidentia, rectum 8
rectal prolapse nos 8


External Ids:

Disease Ontology8 DOID:9307
MeSH34 D012005
NCIt39 C34973
ICD9CM27 569.1
ICD1025 K62.3

Related Diseases for Rectal Prolapse

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Rectal Prolapse:



Diseases related to rectal prolapse

Clinical Features for Rectal Prolapse

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Drugs & Therapeutics for Rectal Prolapse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rectal Prolapse

Drug clinical trials:

Search ClinicalTrials for Rectal Prolapse

Search NIH Clinical Center for Rectal Prolapse

Search CenterWatch for Rectal Prolapse

Genetic Tests for Rectal Prolapse

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Anatomical Context for Rectal Prolapse

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32MalaCards
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MalaCards organs/tissues related to Rectal Prolapse:

32
Colon, Testes, Small intestine, Myeloid

Animal Models for Rectal Prolapse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rectal Prolapse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CFTR, TADA3, FREM1, EFEMP2
2MP:00053888.4EFEMP2, FREM1, CFTR, ELN
3MP:00107687.2ELN, CFTR, TADA3, FREM1, EFEMP2, LSR

Publications for Rectal Prolapse

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50PubMed
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Articles related to Rectal Prolapse:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Comparative effects of different sclerosing agents used to treat rectal prolapse: an experimental study in rats. (23932615)
2013
2
Impact of slow transit constipation on the outcome of laparoscopic ventral rectopexy for obstructed defaecation associated with high grade internal rectal prolapse. (24125518)
2013
3
Perineal stapled prolapse resection for external rectal prolapse: is it worthwhile in the long-term? (23613218)
2013
4
Rectal Prolapse: An Overview of Clinical Features, Diagnosis, and Patient-Specific Management Strategies. (24352613)
2013
5
Abdominal versus perineal approach for treatment of rectal prolapse: comparable safety in a propensity-matched cohort. (23816001)
2013
6
Colonic transit before and after resection rectopexy for full-thickness rectal prolapse. (23913016)
2013
7
Role of the delorme procedure for rectal prolapse in young patients. (23700568)
2013
8
Dynamic MRI (dMRI) as a guide to therapy in children and adolescents with persistent full thickness rectal prolapse: a single centre review. (23480920)
2013
9
Outcome analysis of elderly patients undergoing laparoscopic resection rectopexy for rectal prolapse. (22249437)
2012
10
Is the abdominal repair of rectal prolapse safer than perineal repair in the highest risk patients? An NSQIP analysis. (23044678)
2012
11
Laparoscopic ventral rectopexy for internal rectal prolapse using biological mesh: postoperative and short-term functional results. (22228202)
2012
12
DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme's procedure versus resection rectopexy. (22931552)
2012
13
Gasterophilosis: a major cause of rectal prolapse in working donkeys in Ethiopia. (21870062)
2012
14
Rectal prolapse in a child: an unusual presentation of Clostridium difficile-associated pseudomembranous colitis. (21524633)
2011
15
Rectal prolapse: review according to the personal experience. (21829764)
2011
16
Surgical management of rectal prolapse. (21887563)
2011
17
Outcome of laparoscopic rectopexy versus perineal rectosigmoidectomy for full-thickness rectal prolapse in elderly patients. (21479778)
2011
18
Surgical treatment of rectal prolapse. (21431090)
2011
19
Commentary: Best practice in rectal prolapse. (20557323)
2010
20
Perineal rectosigmoidectomy for gangrenous rectal prolapse. (20518093)
2010
21
Sacral nerve modulation in the treatment of fecal incontinence following repair of rectal prolapse. (20305442)
2010
22
Experience of Altemeier's procedures for a complete rectal prolapse. (21033224)
2010
23
Laparoscopic ventral rectopexy for external rectal prolapse improves constipation and avoids de novo constipation. (19486104)
2010
24
Laparoscopic resection rectopexy for rectal prolapse: a single-center study during 16 years. (20177911)
2010
25
Rectal prolapse: a historical perspective. (19577675)
2009
26
Surgery for internal rectal prolapse. (18462231)
2009
27
Long-term functional outcomes after laparoscopic and open rectopexy for the treatment of rectal prolapse. (18758861)
2008
28
Recurrence and quality of life following perineal proctectomy for rectal prolapse. (18516652)
2008
29
Surgery for rectal prolapse: Orr-Loygue ventral rectopexy with limited dissection prevents postoperative-induced constipation without increasing recurrence. (16830210)
2006
30
Anal sphincter morphology in patients with full-thickness rectal prolapse. (15043290)
2004
31
Management of rectal prolapse: the role of laparoscopic approaches. (14760468)
2003
32
Initial experience with stapled anoplasty in the operative management of prolapsing hemorrhoids and mucosal rectal prolapse. (12034384)
2002
33
Incidence of occult rectal prolapse in patients with clinical rectoceles and defecatory dysfunction. (12501052)
2002
34
The Altemeier repair: outpatient treatment of rectal prolapse. (11330584)
2001
35
One hundred years of rectal prolapse surgery. (10215042)
1999
36
Transsacral rectopexy for recurrent complete rectal prolapse. (10489150)
1999
37
Laparoscopic-assisted resection-rectopexy for rectal prolapse: early and medium follow-up. (9510310)
1998
38
Abdominal resection rectopexy versus Delorme's procedure for rectal prolapse: a predictable outcome. (9112152)
1997
39
Laparoscopic rectopexy for complete rectal prolapse. Clinical outcome and anorectal function tests. (8703148)
1996
40
Results of Delorme's procedure for rectal prolapse. Advantages of a modified technique. (7882798)
1995
41
Different strokes for different folks in repair of rectal prolapse. (7882804)
1995
42
Physiological changes after Delorme's procedure for full-thickness rectal prolapse. (8535796)
1995
43
Stapled laparoscopic rectopexy for rectal prolapse. (7597603)
1995
44
Delorme's procedure for complete rectal prolapse in severely debilitated patients. An analysis of 41 cases. (8181408)
1994
45
Ripstein procedure is an effective treatment for rectal prolapse without constipation. (8482171)
1993
46
Abdominal rectopexy for rectal prolapse: a comparison of techniques. (1555053)
1992
47
A case of congenital colonic stenosis presenting as rectal prolapse. (2359012)
1990
48
Intussusception and its relation to rectal prolapse--a 19th century account. (2198148)
1990
49
Transanal mucosal sleeve resection for the treatment of rectal prolapse in children. (2199658)
1990
50
Rectal prolapse in a child with Peutz-Jeghers syndrome. (7184293)
1982

Genetic Variations for Rectal Prolapse

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Expression for genes affiliated with Rectal Prolapse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rectal Prolapse

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Pathways for genes affiliated with Rectal Prolapse

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53Reactome
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Pathways related to Rectal Prolapse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6ELN, EFEMP2

Compounds for genes affiliated with Rectal Prolapse

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank
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Compounds related to Rectal Prolapse according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trichloroacetic acid449.8ELN, CFTR
2triamcinolone acetonide44 2810.7ELN, CFTR
3formate449.6ELN, CFTR
4suramin44 28 1111.6ELN, CFTR
5dermatan sulfate449.5CFTR, ELN
6lactose44 1110.3ELN, CFTR

GO Terms for genes affiliated with Rectal Prolapse

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16Gene Ontology
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Cellular components related to Rectal Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.5FREM1, EFEMP2

Biological processes related to Rectal Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.6ELN, CFTR

Molecular functions related to Rectal Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.6ELN, EFEMP2

Products for genes affiliated with Rectal Prolapse

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  • Antibodies
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Sources for Rectal Prolapse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet