MCID: RCT011
MIFTS: 43

Rectal Prolapse malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Rectal Prolapse

Aliases & Descriptions for Rectal Prolapse:

Name: Rectal Prolapse 12 29 52 42 14 69
Procidentia, Rectum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9307
ICD10 33 K62.3
ICD9CM 35 569.1
MeSH 42 D012005
NCIt 47 C34973
UMLS 69 C0034888

Summaries for Rectal Prolapse

MalaCards based summary : Rectal Prolapse, also known as procidentia, rectum, is related to trichuriasis and intussusception, and has symptoms including rectal tenesmus An important gene associated with Rectal Prolapse is FBLN5 (Fibulin 5), and among its related pathways/superpathways is Elastic fibre formation. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and skin, and related phenotypes are cellular and craniofacial

Wikipedia : 71 Rectal prolapse often used to mean complete rectal prolapse (external rectal prolapse), where the rectal... more...

Related Diseases for Rectal Prolapse

Diseases related to Rectal Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 trichuriasis 11.3
2 intussusception 10.3
3 fecal incontinence 10.2
4 solitary rectal ulcer syndrome 10.1
5 constipation 10.1
6 pancreatic agenesis 2 10.0 CFTR FREM1
7 colitis 10.0
8 mucositis 10.0
9 vaginitis 10.0
10 hypochondriasis 10.0 DYM KIDINS220
11 cystic hygroma lethal cleft palate 9.9 EFEMP2 FBLN5
12 hemorrhoid 9.9
13 macular degeneration, age-related, 3 9.9 EFEMP2 FBLN5
14 lipoma 9.9
15 proctitis 9.9
16 adenoma 9.9
17 keratoacanthoma 9.8 EFEMP2 FBLN5
18 colorectal cancer 9.8
19 villous adenoma 9.8
20 bulimia nervosa 9.8
21 enterocele 9.8
22 rectal duplication 9.8
23 cystic fibrosis 9.6
24 anorexia nervosa 9.6
25 obsessive-compulsive disorder 9.6
26 peutz-jeghers syndrome 9.6
27 anal fistula 9.6
28 peri-anal fistula 9.6
29 anismus 9.6
30 lymphoma 9.6
31 ileocolitis 9.6
32 infantile myofibromatosis 9.6
33 dermatomyositis 9.6
34 imperforate anus 9.6
35 discitis 9.6
36 urethritis 9.6
37 schistosomiasis 9.6
38 adenocarcinoma 9.6
39 ischemia 9.6
40 intestinal pseudo-obstruction 9.6
41 tuberculosis 9.6
42 myopathy 9.6
43 milk allergy 9.6
44 intestinal obstruction 9.6
45 neurofibromatosis 9.6
46 fasciitis 9.6
47 necrotizing fasciitis 9.6
48 malakoplakia 9.6
49 ulcerative proctitis 9.6
50 cap polyposis 9.6

Comorbidity relations with Rectal Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Fecal Incontinence
Hypothyroidism Osteoporosis

Graphical network of the top 20 diseases related to Rectal Prolapse:



Diseases related to Rectal Prolapse

Symptoms & Phenotypes for Rectal Prolapse

UMLS symptoms related to Rectal Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Rectal Prolapse:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 DYM EFEMP2 FBLN5 GPR68 KIDINS220 PDK4
2 craniofacial MP:0005382 9.46 CFTR DYM FBLN5 FREM1
3 respiratory system MP:0005388 9.43 CFTR EFEMP2 FBLN5 FREM1 GPR65 GPR68
4 skeleton MP:0005390 9.1 FREM1 GPR65 GPR68 PDK4 DYM EFEMP2

Drugs & Therapeutics for Rectal Prolapse

Drugs for Rectal Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Menthol Approved Phase 4,Phase 1 2216-51-5 16666
5 Anesthetics Phase 4,Phase 3
6 Epinephryl borate Phase 4
7 Racepinephrine Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Anesthetics, Local Phase 4
10 Central Nervous System Depressants Phase 4
11 Cola Nutraceutical Phase 1
12
Cefuroxime Approved 55268-75-2 5361202 5479529
13 cefuroxime axetil
14 Chelating Agents
15 Anti-Bacterial Agents
16 Anti-Infective Agents
17 Antibiotics, Antitubercular
18 Analgesics
19 Hemostatics

Interventional clinical trials:

(show top 50) (show all 69)
id Name Status NCT ID Phase
1 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
2 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
3 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4
4 Efficacy Study of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
5 A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4
6 Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Recruiting NCT01346436 Phase 4
7 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Recruiting NCT02216305 Phase 4
8 Prospective Randomized Trial Comparing THD Versus Stapler Operation for 3rd Degree Hemorrhoids Unknown status NCT00823784 Phase 3
9 Pexy Versus Non-pexy for Full Thickness Rectal Prolapse Completed NCT01022034 Phase 3
10 Clinical Performance of the GYNECARE PROLIFT + M* Pelvic Floor Repair System as a Device for Pelvic Organ Prolapse Completed NCT00833001 Phase 2, Phase 3
11 Prenatal Pelvic Floor Prevention (3PN) Completed NCT00551551 Phase 3
12 Bulking Agent Versus Electrostimulation Therapy in Anal Incontinence Not yet recruiting NCT03052946 Phase 2, Phase 3
13 Percutaneous Tibial Nerve Stimulation for the Treatment of Fecal Incontinence Completed NCT00977652 Phase 2
14 Perfusion Assessment in Laparoscopic Left Anterior Resection Completed NCT01560377 Phase 1
15 Clinical Study for the Evaluation of the Efficiency of a Device for the Diagnosis of an Internal Rectal Prolapse, a Pelvic Floor Ptosis and for the Determination of an Internal Hernia Into the Douglas Pouch Unknown status NCT00836680
16 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209
17 A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing Unknown status NCT01880918
18 Will Cleaning the Bowel With an Enema Before Vaginal Prolapse Surgery Prevent Complications? Unknown status NCT00981539
19 Randomized,Multicentric Study to Treat Prolapse After Hysterectomy With Amreich Procedure or Total Prolift Procedure Unknown status NCT00572702
20 Laparoscopic Sacropexy: Comparison of Mesh Attachment Unknown status NCT00928239
21 TSTstarr + for Treatment of Severe Prolapsed Hemorrhoids --- a Multi-center Randomized Controlled Clinical Trail Unknown status NCT02295592
22 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
23 Effectiveness Prolift+M Versus Conventional Vaginal Prolapse Surgery Unknown status NCT02231099
24 Prophylactic Antibiotic Treatment During Vaginal Repair Unknown status NCT00162604
25 The Immune Reactivity of Biofilms in Vaginal Mesh Erosion. Unknown status NCT00564044
26 Comparative Study Between Delorme Operation With or Without Postanal Repair in Treatment of Complete Rectal Prolapse Completed NCT01656369
27 Laparoscopic Ventral Mesh Rectopexy Versus Delorme's Operation in Management of Complete Rectal Prolapse Completed NCT02601326
28 Laparoscopic Rectopexy for Rectal Prolapse Completed NCT00946205
29 TEM Assisted Perineal Rectopexy in Treatment of Rectal Prolapse Completed NCT02609555
30 A Modified Technique to Facilitate Pealing of the Rectal Mucosa in Delorme Operation Completed NCT02901210
31 Long Term Results of STARR With Contour Transtar Completed NCT02971332
32 International Multicenter Prospective Transtar Registry Completed NCT00909116
33 Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis Completed NCT01301417
34 Robotic-assisted Laparoscopic Sacrocolpopexy Completed NCT00581334
35 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400
36 Pelvic Floor Repair Systems for Prolapse Repair Completed NCT00638235
37 Pelvic Floor Muscle Training (PFMT) in Treatment and Prevention of POP (POP Study) Completed NCT00271297
38 Comparison Study of Surgical Staplers for the Treatment of Hemorrhoids Completed NCT01306877
39 Safety and Performance of the Covidien EEA Hemorrhoid and Prolapse Stapling Set in a Hemorrhoidopexy Procedure Completed NCT01169311
40 Delivery Method and Risk for Urogenital Prolapse 15-20 Years Later Completed NCT01766193
41 Validation of a New Sexuality Questionnaire for Patients With Urinary Incontinence or Pelvic Organ Prolapse Completed NCT01548989
42 Validation of a French Version of the PISQ-R Completed NCT01548976
43 Graft-Augmented Rectocele Repair-A Randomized Surgical Trial Completed NCT00321867
44 Clinical Study to Investigate the Effectiveness of the TOPAS System to Treat Fecal Incontinence Completed NCT01090739
45 Endoluminal and Needlescopic Assisted Repair of Rectal Prolapse Recruiting NCT01980043
46 Pathologic Assessment of Rectal Prolapse in the Young Recruiting NCT03012464
47 An International Double Cohort Study to Compare Laparoscopic Ventral Rectopexy With Laparoscopic Resection Rectopexy Recruiting NCT01595412
48 Materiovigilance After Urinary Incontinence or Prolapse Surgery Recruiting NCT03052985
49 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
50 Laparoscopic Ventral Mesh Rectopexy Combined With or Without Stapled Trans-anal Rectal Resection for Obstructed Defecation Syndrome Recruiting NCT03060330

Search NIH Clinical Center for Rectal Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Rectal Prolapse

Genetic tests related to Rectal Prolapse:

id Genetic test Affiliating Genes
1 Rectal Prolapse 29

Anatomical Context for Rectal Prolapse

MalaCards organs/tissues related to Rectal Prolapse:

39
Colon, Testes, Skin, Myeloid, Small Intestine, Uterus

Publications for Rectal Prolapse

Articles related to Rectal Prolapse:

(show top 50) (show all 604)
id Title Authors Year
1
Bio-Thiersch as an Adjunct to Perineal Proctectomy Reduces Rates of Recurrent Rectal Prolapse. ( 28059915 )
2017
2
Systematic review on recent advances in the surgical management of rectal prolapse. ( 27711030 )
2017
3
Abdominal rectopexy for the treatment of internal rectal prolapse: a systematic review and meta-analysis. ( 27943547 )
2017
4
Resolution of Rectal Prolapse by Vaginal Reconstruction. ( 27898453 )
2017
5
Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse. ( 27275090 )
2016
6
Rectal prolapse traumatizes rectal neuromuscular microstructure explaining persistent rectal dysfunction. ( 27599704 )
2016
7
Optimizing Treatment for Rectal Prolapse. ( 27582654 )
2016
8
Perineal stapled prolapse resection (PSPR) for external rectal prolapse in high morbidity patients. ( 27842015 )
2016
9
Detection and first characterization of an uncommon haptoglobin in porcine saliva of pigs with rectal prolapse by using boronic acid sample enrichment. ( 27829481 )
2016
10
High-grade internal rectal prolapse: Does it explain so-called "idiopathic" faecal incontinence? ( 26700198 )
2016
11
Internal rectal prolapse: Definition, assessment and management in 2016. ( 27865742 )
2016
12
A novel technique for correction of total rectal prolapse: Endoscopic-assisted percutaneous rectopexy with the aid of the EndoLifter. ( 27717630 )
2016
13
Laparoscopic ventral mesh rectopexy in male patients with internal or external rectal prolapse. ( 27911060 )
2016
14
Perineal Rectosigmoidectomy (Altemeier Procedure) as Treatment of Strangulated Rectal Prolapse. ( 27384429 )
2016
15
Long-term outcome of perineal rectosigmoidectomy for rectal prolapse. ( 27345263 )
2016
16
Evisceration of the small bowel through a perforated and prolapsed sigmoid colon: an unusual presentation of rectal prolapse. ( 27084900 )
2016
17
Application of anchoring stitch prevents rectal prolapse in laparoscopic assisted anorectal pullthrough. ( 27680599 )
2016
18
Perineal rectosigmoidectomy for incarcerated rectal prolapse (Altemeier's procedure). ( 27528816 )
2016
19
Perineal stapled prolapse resection for full thickness external rectal prolapse: a multicentre prospective study. ( 26969880 )
2016
20
Evolution of male rectal prolapse surgery and initial experience of robotic rectopexy in men. ( 27830430 )
2016
21
Life after PROSPER. What do people do for external rectal prolapse? ( 27481719 )
2016
22
Perineal Approach in the Treatment of Rectal Prolapse (Altemeier's Procedure): Analysis of Long-Term Outcome. ( 27099051 )
2016
23
Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts. ( 27689329 )
2016
24
Robot-assisted versus laparoscopic ventral rectopexy for external, internal rectal prolapse and enterocele: a randomised controlled trial. ( 26919191 )
2016
25
A 9-Month-Old Presenting With Rectal Prolapse. ( 26612186 )
2016
26
Laparoscopic Suture Rectopexy for Persistent Rectal Prolapse in Children: Is It a Safe and Effective First-Line Intervention? ( 26618707 )
2016
27
Laparoscopic ventral rectopexy in male patients with external rectal prolapse is associated with a high reoperation rate. ( 27641548 )
2016
28
Incarcerated gravid uterus through a rectal prolapse: First case report. ( 27553914 )
2016
29
Complete rectal prolapse in young Egyptian males: Is schistosomiasis really condemned? ( 28070233 )
2016
30
Outcomes following sclerotherapy for mucosal rectal prolapse with oily phenol injection: single-centre review. ( 27988851 )
2016
31
Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum. ( 27477670 )
2016
32
Rectal Prolapse in Children: Significance and Management. ( 27086003 )
2016
33
Laparoscopic ventral mesh rectopexy versus Delorme's operation in management of complete rectal prolapse: a prospective randomized study. ( 27225971 )
2016
34
Hiatal hernia, mitral valve prolapse and defecatory disorders: An underlying rectal prolapse? ( 26925980 )
2016
35
Complete rectal prolapse vs prolapsed hemorrhoids: points to ponder. ( 27642427 )
2016
36
Laparoscopic Protack rectopexy for the management of full thickness rectal prolapse - a video vignette. ( 27753180 )
2016
37
Trans-anal endoscopic microsurgery for internal rectal prolapse. ( 26690927 )
2016
38
Laparoscopic ventral mesh rectopexy for complete rectal prolapse: A retrospective study evaluating outcomes in North Indian population. ( 27152139 )
2016
39
Quality of patient information online for rectal prolapse. ( 26850764 )
2016
40
Short term outcome of laparoscopic ventral rectopexy for rectal prolapse. ( 27648031 )
2016
41
What operation for recurrent rectal prolapse after previous Delorme's procedure? A practical reality. ( 27462393 )
2016
42
Laparoscopic-Assisted Altemeier's Procedure for Recurrent Strangulated Rectal Prolapse: A Case Report. ( 27811832 )
2016
43
Laparoscopic Rectopexy: First Option for Rectal Prolapse? ( 27172526 )
2016
44
Ogilvie's syndrome after rectal prolapse repair and total hemorrhoidectomy: Case report and Discussion. ( 26862413 )
2016
45
Transanal evisceration of the small bowel a rare complication of rectal prolapse. ( 26708948 )
2016
46
Vaginal prolapse with urinary bladder incarceration and consecutive irreducible rectal prolapse in a dog. ( 27660054 )
2016
47
Rectal Prolapse in Women-Outcomes of Perineal and Abdominal Approaches. ( 27011522 )
2015
48
Posterior Sagittal Mesh Rectopexy (PSMR) and Anal Encirclement with Polypropylene Mesh for Correction of Complete Rectal Prolapse-a New Application. ( 26246712 )
2015
49
Contour Transtar in true rectal prolapse. ( 26040046 )
2015
50
Surgical Management for Rectal Prolapse: An Update. ( 25897588 )
2015

Variations for Rectal Prolapse

Expression for Rectal Prolapse

Search GEO for disease gene expression data for Rectal Prolapse.

Pathways for Rectal Prolapse

Pathways related to Rectal Prolapse according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.49 EFEMP2 FBLN5

GO Terms for Rectal Prolapse

Cellular components related to Rectal Prolapse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 8.62 EFEMP2 FREM1

Biological processes related to Rectal Prolapse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 8.96 FBLN5 FREM1
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 8.62 CFTR GPR68

Molecular functions related to Rectal Prolapse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 8.62 CFTR KIDINS220

Sources for Rectal Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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