MCID: RCT020
MIFTS: 31

Rectum Adenocarcinoma malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectum Adenocarcinoma

Aliases & Descriptions for Rectum Adenocarcinoma:

Name: Rectum Adenocarcinoma 12 14
Adenocarcinoma of Rectum 12 69
Rectal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1996
NCIt 47 C9383
SNOMED-CT 64 254582000
UMLS 69 C0149978

Summaries for Rectum Adenocarcinoma

Disease Ontology : 12 A rectum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Rectum Adenocarcinoma, also known as adenocarcinoma of rectum, is related to rectum mucinous adenocarcinoma and rectum signet ring adenocarcinoma. An important gene associated with Rectum Adenocarcinoma is SLC14A2 (Solute Carrier Family 14 Member 2), and among its related pathways/superpathways are Thyroid cancer and EGFR Transactivation by Gastrin. The drugs Lidocaine and Prilocaine have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and colon.

Related Diseases for Rectum Adenocarcinoma

Diseases related to Rectum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 rectum mucinous adenocarcinoma 10.9
2 rectum signet ring adenocarcinoma 10.9
3 rectal neoplasm 10.9
4 peritoneal benign neoplasm 10.3 CDX2 KRT20
5 dystonia 10.3 CDX2 KRT20
6 anal canal paget's disease 10.3 CDX2 KRT20
7 clitoris cancer 10.3 CDX2 KRT20
8 extramedullary plasmacytoma 10.2 CDX2 KRT20
9 cervix endometriosis 10.2 CDX2 KRT20
10 apocrine adenocarcinoma 10.2 CDX2 KRT20
11 mucosal melanoma 10.2 CDX2 KRT20
12 small intestine leiomyoma 10.2 KRT20 TP53
13 clear cell hidradenoma 10.2 KRT20 TP53
14 neuroendocrine tumor 10.2 CDX2 KRT20
15 spiradenoma 10.2 KRT20 TP53
16 neurofibrosarcoma 10.2 CDX2 KRT20
17 breast pericanalicular fibroadenoma 10.2 KRT20 TP53
18 uterine ligament mucinous adenocarcinoma 10.2 CDX2 KRAS
19 agenesis and aplasia of uterine body 10.2 KRAS KRT20
20 myotonia congenita 10.2 CDX2 KRT20
21 ureter adenocarcinoma 10.2 CDX2 KRAS
22 paraphimosis 10.2 KRT20 TP53
23 breast ductal carcinoma 10.1 KRAS TP53
24 mitochondrial neurogastrointestinal encephalopathy disease 10.1 KRAS TP53
25 infantile thalamic degeneration 10.1 KRAS TP53
26 spastic ataxia 5 10.1 CDX2 KRT20 TP53
27 pacinian tumor 10.1 CDX2 KRT20 TP53
28 gallbladder signet ring cell adenocarcinoma 10.1 CDX2 KRT20 TP53
29 fallopian tube adenocarcinoma 10.1 CDX2 KRT20 TP53
30 pituitary carcinoma 10.1 CDX2 KRT20 TP53
31 adult syndrome 10.1 KRAS TP53
32 atopic dermatitis 10.1 CDX2 KRT20 TP53
33 mesenchymoma 10.1 CDX2 KRT20
34 spinal muscular atrophy with progressive myoclonic epilepsy 10.1 CDX2 KRT20 TP53
35 bone deterioration disease 10.1 KRAS TP53
36 pelvic inflammatory disease 10.1 CDX2 KRAS KRT20
37 anemia of prematurity 10.1 CDX2 KRAS KRT20
38 large cell neuroendocrine carcinoma 10.1 CDX2 KRAS KRT20
39 sagittal sinus thrombosis 10.1 CDX2 KRAS KRT20
40 meninges hemangiopericytoma 10.1 CDX2 KRAS KRT20
41 neuroretinitis 10.1 CDX2 KRAS KRT20
42 acute stress disorder 10.1 CDX2 KRAS KRT20
43 inhibited male orgasm 10.1 KRAS TP53
44 postpoliomyelitis syndrome 10.1 CDX2 KRAS TP53
45 aicardi-goutieres syndrome 10.1 CDX2 KRAS TP53
46 spinal cord intramedullary teratoma 10.0 CD6 TP53
47 familial lipoprotein lipase deficiency 10.0 CD6 KRAS SLC14A2
48 ideomotor apraxia 10.0 CDX2 KRAS TP53
49 acquired hemangioma 10.0 CDX2 TP53
50 exudative glomerulonephritis 10.0 KRAS TP53

Graphical network of the top 20 diseases related to Rectum Adenocarcinoma:



Diseases related to Rectum Adenocarcinoma

Symptoms & Phenotypes for Rectum Adenocarcinoma

Drugs & Therapeutics for Rectum Adenocarcinoma

Drugs for Rectum Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 219)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Prilocaine Approved Phase 4 721-50-6 4906
3 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
4 Anesthetics Phase 4,Phase 3,Phase 2
5 Anesthetics, Local Phase 4,Phase 2
6 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
7 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
8 Diuretics, Potassium Sparing Phase 4
9 Sodium Channel Blockers Phase 4
10
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
11
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
12
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
13
Cetuximab Approved Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
14
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
15
Cyclosporine Approved, Investigational, Vet_approved Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
16
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
17
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
18
Raltitrexed Approved, Investigational Phase 3,Phase 2 112887-68-0 104758
19
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
20
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
21
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
22
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
23 Tegafur Approved Phase 3,Phase 2 17902-23-7
24
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
25
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
26
Floxuridine Approved Phase 3,Phase 2,Phase 1 50-91-9 5790
27
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
28
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
30
Camptothecin Experimental Phase 3,Phase 1,Phase 2 7689-03-4
31
Doxil Approved June 1999 Phase 3,Phase 2 31703
32
Vatalanib Investigational Phase 3 212141-54-3 151194
33
Eniluracil Investigational Phase 3 59989-18-3
34 Antimetabolites Phase 3,Phase 2,Phase 1
35 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
36 Disinfectants Phase 3
37 Antidotes Phase 3,Phase 2,Phase 1
38 Calcium, Dietary Phase 3,Phase 2,Phase 1
39 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
40 Protective Agents Phase 3,Phase 2,Phase 1
41
Cobalt Phase 3 7440-48-4 104729
42 Antibodies Phase 3,Phase 1,Phase 2,Early Phase 1
43 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2,Early Phase 1
44 Antifungal Agents Phase 3,Phase 2
45 Anti-Infective Agents Phase 3,Phase 1,Phase 2
46 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 3,Phase 2,Phase 1
48 Calcineurin Inhibitors Phase 3,Phase 2
49 Dermatologic Agents Phase 3,Phase 2
50 Immunoglobulins Phase 3,Phase 1,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 310)
id Name Status NCT ID Phase
1 Impact of Local Anesthesia Type on Cancer Detection Rate in Transrectal Ultrasound Guided Prostate Biopsy Completed NCT02025361 Phase 4
2 J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma Unknown status NCT00070005 Phase 3
3 Resource-Sparing Curative Treatment for Rectal Cancer Unknown status NCT01459328 Phase 3
4 Radiation Therapy and Capecitabine With or Without Oxaliplatin in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Rectal Cancer Unknown status NCT00227747 Phase 3
5 Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00182715 Phase 3
6 Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer Unknown status NCT00002896 Phase 3
7 Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00070213 Phase 3
8 Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil Unknown status NCT00389870 Phase 3
9 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3
10 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3
11 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3
12 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3
13 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3
14 Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer Unknown status NCT00482222 Phase 3
15 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3
16 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer Unknown status NCT00002893 Phase 3
17 A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum Completed NCT00145769 Phase 3
18 Study of Two Techniques of Rectal Reservoir in Low Anterior Resection of Rectum Completed NCT01396928 Phase 2, Phase 3
19 Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00003594 Phase 3
20 Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver Completed NCT00023868 Phase 3
21 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3
22 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3
23 Efficiency of Two Dimensional High Definition Versus Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery Completed NCT01498354 Phase 3
24 Capecitabine and Oxaliplatin or Standard Follow-Up Care in Treating Patients Who Have Undergone Surgery for Locally Advanced Rectal Cancer Completed NCT00427713 Phase 3
25 Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer Completed NCT00766155 Phase 3
26 Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer Completed NCT00296608 Phase 3
27 SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed Completed NCT00002551 Phase 3
28 Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed Completed NCT00002523 Phase 3
29 Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer Completed NCT00064181 Phase 3
30 Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00392899 Phase 3
31 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer Completed NCT00026273 Phase 3
32 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3
33 Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer Completed NCT00003873 Phase 3
34 Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed Completed NCT00003422 Phase 3
35 Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated Completed NCT00025337 Phase 3
36 Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases Completed NCT00268398 Phase 3
37 Optimized Chemotherapy Followed by Maintenance With Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot be Removed by Surgery (DREAM) Completed NCT00265824 Phase 3
38 Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Completed NCT00303771 Phase 3
39 Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer Completed NCT00062426 Phase 3
40 Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer Completed NCT00008060 Phase 3
41 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004885 Phase 3
42 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer Completed NCT00003287 Phase 3
43 PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study Completed NCT00911170 Phase 3
44 Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer Completed NCT00975897 Phase 2, Phase 3
45 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00316914 Phase 3
46 Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer Completed NCT00002716 Phase 3
47 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed NCT01099449 Phase 3
48 Combination Chemotherapy in Treating Patients With Colorectal Cancer Completed NCT00006103 Phase 3
49 Rectal Reconstruction in Treating Patients Who Are Undergoing Surgery for Rectal Cancer Completed NCT00238381 Phase 3
50 Safety of a Boost (CXB or EBRT) in Combination With Neoadjuvant Chemoradiotherapy for Early Rectal Adenocarcinoma Recruiting NCT02505750 Phase 3

Search NIH Clinical Center for Rectum Adenocarcinoma

Genetic Tests for Rectum Adenocarcinoma

Anatomical Context for Rectum Adenocarcinoma

MalaCards organs/tissues related to Rectum Adenocarcinoma:

39
Lung, Skin, Colon

Publications for Rectum Adenocarcinoma

Articles related to Rectum Adenocarcinoma:

id Title Authors Year
1
A Rare Pattern of Lung Metastasis of Rectum Adenocarcinoma. ( 26784521 )
2016
2
Scrotal skin metastasis from rectum adenocarcinoma. ( 24416494 )
2013
3
Adjuvant modified FOLFOX-4 in patients with stage III rectum adenocarcinoma. ( 21790235 )
2011
4
Synchronous isolated adrenal metastasis from rectum adenocarcinoma. ( 19380305 )
2009
5
Surgical treatment of colon and rectum adenocarcinoma in elderly patients. ( 1434647 )
1992

Variations for Rectum Adenocarcinoma

Expression for Rectum Adenocarcinoma

Search GEO for disease gene expression data for Rectum Adenocarcinoma.

Pathways for Rectum Adenocarcinoma

Pathways related to Rectum Adenocarcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.42 KRAS TP53
2
Show member pathways
10.04 EDNRA KRAS

GO Terms for Rectum Adenocarcinoma

Sources for Rectum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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