MCID: RCR022
MIFTS: 29

Recurrent Acute Pancreatitis malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Recurrent Acute Pancreatitis

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32MalaCards
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MalaCards: Recurrent Acute Pancreatitis is related to acute pancreatitis and pancreatitis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1). The compounds bicarbonate and ursodeoxycholic acid have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Recurrent Acute Pancreatitis

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Sources:
48Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
recurrent acute pancreatitis:
Inheritance: Sporadic; Prevalence: 1-5/10000


Aliases & Descriptions:

recurrent acute pancreatitis 48


External Ids:

SNOMED-CT via Orphanet57 197458008
ICD10 via Orphanet26 K85.0, K85.1, K85.2 K85.3, K85.8, K85.9, more
UMLS via Orphanet61 C0267937

Related Diseases for Recurrent Acute Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pancreatitis, Chronic family:

Acute Pancreatitis Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 recurrent acute pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis31.6SCT, CFTR, SPINK1
2pancreatitis31.6SPINK1, CFTR, SCT
3cystic fibrosis30.6SPINK1, CFTR, SCT
4hyperparathyroidism30.4SCT
5pancreatic cancer30.2SPINK1, SCT
6adenoma30.0SPINK1, SCT
7cholangitis30.0CFTR
8polycystic kidney disease, autosomal dominant30.0CFTR, SCT
9duodenitis10.5
10primary hyperparathyroidism10.3
11sjogren's syndrome10.0
12arteriovenous malformation10.0
13somatostatinoma10.0
14pancreatic somatostatinoma10.0
15systemic lupus erythematosus10.0
16psoriatic arthritis10.0
17wegener's granulomatosis10.0
18eosinophilic gastroenteritis10.0
19intussusception10.0
20ulcerative colitis10.0
21polycystic kidney disease10.0
22acute cholangitis10.0
23paraganglioma10.0
24cholelithiasis10.0
25acute leukemia10.0
26propionic acidemia10.0
27hepatitis a10.0
28arthritis10.0
29autosomal dominant disease10.0
30eating disorder10.0
31gastroenteritis10.0
32giant cell tumor10.0
33hepatitis10.0
34kidney disease10.0
35leukemia10.0
36lupus erythematosus10.0
37lymphoblastic leukemia10.0
38neuroendocrine tumor10.0
39panniculitis10.0
40peritonitis10.0
41tuberculosis10.0
42tropical calcific pancreatitis10.0SPINK1
43duodenal ulcer10.0SCT
44diarrhea10.0CFTR
45hemochromatosis10.0CFTR
46hereditary pancreatitis10.0CFTR, SPINK1
47hypercalcemia10.0SPINK1, SCT
48infertility10.0SPINK1, CFTR
49cystic kidney10.0CFTR, SCT
50steatorrhea10.0SCT, CFTR

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to recurrent acute pancreatitis

Clinical Features for Recurrent Acute Pancreatitis

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Drugs & Therapeutics for Recurrent Acute Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Recurrent Acute Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Recurrent Acute Pancreatitis

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Search CenterWatch for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

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Anatomical Context for Recurrent Acute Pancreatitis

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Animal Models for Recurrent Acute Pancreatitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Recurrent Acute Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6SPINK1, CFTR, APOE
2MP:00053767.7SPINK1, CFTR, SCT, APOE

Publications for Recurrent Acute Pancreatitis

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Genetic Variations for Recurrent Acute Pancreatitis

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Expression for genes affiliated with Recurrent Acute Pancreatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for genes affiliated with Recurrent Acute Pancreatitis

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Compounds for genes affiliated with Recurrent Acute Pancreatitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1bicarbonate4410.1SCT
2ursodeoxycholic acid44 11 2411.7SCT, APOE
3tetrodotoxin44 59 2811.6SCT, APOE
4formate449.5CFTR, APOE
5fluoride449.5CFTR, SPINK1
6dermatan sulfate449.5APOE, CFTR
7h2dids449.4CFTR, SCT
8glibenclamide44 28 49 5912.4CFTR, APOE
9nppb44 59 2811.4CFTR, SCT
10ibuprofen44 28 49 11 2413.4APOE, CFTR
11dids44 2810.4CFTR, SCT
12thyroxine44 2410.4SCT, APOE
13taurocholate449.4CFTR, SCT
14chloroquine44 2 49 28 1113.4CFTR, APOE
15suramin44 28 1111.4APOE, CFTR
16amiloride44 28 1111.3CFTR, SCT
17carbohydrates449.2APOE, CFTR
18carbachol44 28 1111.2SCT, CFTR
19isoproterenol44 1110.0CFTR, SCT
20guanine44 11 2411.0SCT, APOE
21valine449.0APOE, CFTR
22chloride449.0CFTR, SCT
23trypsinogen448.9SPINK1, CFTR, SCT
24biotin44 11 2410.9CFTR, SCT, APOE
25ibmx44 28 5910.9APOE, SCT, CFTR
26indomethacin44 59 28 1111.9CFTR, SCT, APOE
27acetylcholine44 49 28 11 2412.9APOE, SCT, CFTR
28cyclosporin a44 28 5910.9CFTR, SCT, APOE
29glutamine448.9APOE, SCT, CFTR
30dopamine44 28 11 2411.9APOE, SCT, CFTR
31aspartate448.8CFTR, SCT, APOE
32testosterone44 59 11 2411.8APOE, SCT, CFTR
33glutamate448.7CFTR, SCT, APOE
34cysteine448.7CFTR, SCT, APOE
35serine448.4SPINK1, CFTR, SCT, APOE

GO Terms for genes affiliated with Recurrent Acute Pancreatitis

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Sources:
16Gene Ontology
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Cellular components related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1early endosomeGO:0057699.1CFTR, APOE

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3SCT, APOE
2vasodilationGO:0423118.8CFTR, APOE

Products for genes affiliated with Recurrent Acute Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Recurrent Acute Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet