MCID: RCR022
MIFTS: 45

Recurrent Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Endocrine diseases, Bone diseases, Immune diseases categories
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Summaries for Recurrent Acute Pancreatitis

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33MalaCards
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MalaCards: Recurrent Acute Pancreatitis is related to acute pancreatitis and pancreatitis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1). The compounds ursodeoxycholic acid and tetrodotoxin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Classifications for Recurrent Acute Pancreatitis

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49Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
recurrent acute pancreatitis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

recurrent acute pancreatitis 49


External Ids:

SNOMED-CT via Orphanet59 197458008
ICD10 via Orphanet26 K85.0, K85.1, K85.2 K85.3, K85.8, K85.9, more
UMLS via Orphanet63 C0267937

Related Diseases for Recurrent Acute Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
recurrent acute pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis31.6SCT, CFTR, SPINK1
2pancreatitis31.6SCT, CFTR, SPINK1
3cystic fibrosis30.6SPINK1, CFTR, SCT
4hereditary pancreatitis30.1SPINK1, CFTR
5pancreatic cancer30.1SPINK1, SCT
6duodenitis10.6
7hypertriglyceridemia10.4
8primary hyperparathyroidism10.3
9hyperparathyroidism10.3
10gastric duplication cysts10.2
11tropical calcific pancreatitis10.1SPINK1
12villous adenoma10.1
13eosinophilic gastroenteritis10.1
14intussusception10.1
15ulcerative colitis10.1
16polycystic kidney disease10.1
17cholelithiasis10.1
18propionic acidemia10.1
19sjogren's syndrome10.1
20arteriovenous malformation10.1
21somatostatinoma10.1
22systemic lupus erythematosus10.1
23psoriatic arthritis10.1
24wegener's granulomatosis10.1
25paraganglioma10.1
26adenoma10.1
27arthritis10.1
28cholangitis10.1
29eating disorder10.1
30gastroenteritis10.1
31giant cell tumor10.1
32hepatitis10.1
33kidney disease10.1
34leukemia10.1
35lupus erythematosus10.1
36lymphoblastic leukemia10.1
37neuroendocrine tumor10.1
38panniculitis10.1
39peritonitis10.1
40tuberculosis10.1
41agenesis of the dorsal pancreas10.1
42annular pancreas10.1
43inflammatory myofibroblastic tumor10.1
44aneurysm10.1
45parkinson's disease10.1APOE
46hypercalcemia10.0SPINK1, SCT
47steatorrhea10.0SCT, CFTR
48exocrine pancreatic insufficiency10.0SCT, CFTR
49cystic kidney10.0SCT, CFTR
50infertility10.0CFTR, SPINK1

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to recurrent acute pancreatitis

Symptoms for Recurrent Acute Pancreatitis

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Drugs & Therapeutics for Recurrent Acute Pancreatitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Recurrent Acute Pancreatitis

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

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Anatomical Context for Recurrent Acute Pancreatitis

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33MalaCards
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MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

33
Pancreas, Testes, Smooth muscle, Kidney, Pancreatic islet

Animal Models for Recurrent Acute Pancreatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Recurrent Acute Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6APOE, CFTR, SPINK1
2MP:00030128.5SPINK1, CFTR, APOE
3MP:00053818.3APOE, CFTR, SPINK1
4MP:00053768.0APOE, SCT, CFTR, SPINK1

Publications for Recurrent Acute Pancreatitis

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52PubMed
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Articles related to Recurrent Acute Pancreatitis:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Recurrent acute pancreatitis in a patient with wirsungocele and neuroendocrine tumor of ampulla of Vater. (23306346)
2013
2
Roux-en-y biliary by-pass - a new approach in the treatment of hypertriglyceridemia induced recurrent acute pancreatitis. Clinical case study. (23612621)
2013
3
Gadolinium induced recurrent acute pancreatitis. (23395575)
2013
4
Recurrent acute pancreatitis and cholangitis in a patient with autosomal dominant polycystic kidney disease. (23543834)
2013
5
6-Mercaptopurine-induced recurrent acute pancreatitis in children with acute lymphoblastic leukemia/lymphoma. (23138114)
2013
6
Anatomic pathways of peripancreatic fluid draining to mediastinum in recurrent acute pancreatitis: visible human project and CT study. (23614005)
2013
7
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
8
Recurrent acute pancreatitis probably induced by rosuvastatin therapy: a case report. (22536267)
2012
9
Isoniazid-induced recurrent acute pancreatitis. (21873403)
2011
10
Primary hyperparathyroidism presenting as recurrent acute pancreatitis: A case report and review of literature. (21584170)
2011
11
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
12
Recurrent Acute Pancreatitis and Therapy for Ulcerative Colitis. (21060690)
2010
13
SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. (19888199)
2010
14
Recurrent acute pancreatitis caused by a gastric duplication cyst communicating with an aberrant pancreatic duct. (20647650)
2010
15
Duodenal duplication cyst communicating with the main pancreatic duct. A rare cause of recurrent acute pancreatitis. (21136003)
2010
16
A Case of Recurrent Acute Pancreatitis due to Pancreatic Arteriovenous Malformation. (20479928)
2010
17
Duodenal duplication cyst (DDC) communicating with the pancreatobiliary duct--a rare cause of recurrent acute pancreatitis in adults. (19440800)
2010
18
Recurrent acute pancreatitis secondary to a duodenal duplication cyst in an adult. A case report and literature review. (19893770)
2009
19
Cystic fibrosis transmembrane conductance regulator ion channel function testing in recurrent acute pancreatitis. (18360295)
2008
20
Cancer of the papilla causing recurrent acute pancreatitis and mimicking a pancreatic stone. (17285500)
2007
21
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
22
Recurrent acute pancreatitis probably secondary to lisinopril. (17233197)
2006
23
Recurrent acute pancreatitis due to a hydatid cyst of the pancreatic head: a case report and review of the literature. (16006687)
2005
24
Hereditary pancreatitis--a rare differential diagnosis in patients with menstruation-associated recurrent acute pancreatitis: a case report. (15106365)
2004
25
Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. (15307877)
2004
26
Recurrent acute pancreatitis after isoniazid. (15366703)
2004
27
Cystic fibrosis, pregnancy, and recurrent, acute pancreatitis. (12658041)
2003
28
Long-term results of endoscopic management of pancreas divisum with recurrent acute pancreatitis. (11868012)
2002
29
Spontaneous splenic rupture in recurrent acute pancreatitis. (12216053)
2002
30
Cavernous pancreatic ductal ectasia with smooth muscle proliferation causing recurrent acute pancreatitis. (11876255)
2001
31
Aetiologies of recurrent acute pancreatitis: acute or chronic relapsing disease? (11880695)
2001
32
Recurrent Acute Pancreatitis. (11560783)
2001
33
Pancreatic islet cell tumours presenting as recurrent acute pancreatitis: imaging features in three cases. (11903191)
2001
34
Cavernous Pancreatic Ductal Ectasia with Smooth Muscle Proliferation Causing Recurrent Acute Pancreatitis. (12754393)
2001
35
Does recurrent acute pancreatitis lead to chronic pancreatitis? Sequential morphological and biochemical studies. (9163778)
1997
36
Recurrent panniculitis as the first clinical manifestation of recurrent acute pancreatitis secondary to cholelithiasis. (8683492)
1996
37
Prevention of recurrent acute pancreatitis in patients with severe hypertriglyceridemia: value of regular plasmapheresis. (8783340)
1996
38
Recurrent acute pancreatitis: an additional manifestation of the "wandering spleen" syndrome". (8633547)
1996
39
Recurrent acute pancreatitis as a complication of cystic fibrosis: report of one case treated surgically. (1768003)
1991
40
Recurrent acute pancreatitis--rarely idiopathic: 1989 Du Pont lecture. (2268808)
1990
41
Atypical eating disorder masquerading as recurrent acute pancreatitis: the value of multiple pancreatic serological markers. (1689331)
1990
42
Recurrent acute pancreatitis as a manifestation of Wegener's granulomatosis. (2364848)
1990
43
Recurrent acute pancreatitis associated with pancreas divisum. (3337068)
1988
44
Pathophysiologic factors in recurrent acute pancreatitis. (3935840)
1985
45
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
46
Abscess of pancreas; a sequelae of recurrent acute pancreatitis. (13295462)
1955
47
Further clinical study of the effect of vagotomy on recurrent acute pancreatitis. (13118354)
1954
48
The surgical treatment of recurrent acute pancreatitis by endocholedochal sphincterotomy. (18901326)
1948
49
Recurrent acute pancreatitis; observations on etiology and surgical treatment. (18893291)
1948
50
Recurrent acute pancreatitis; observations on etiology and surgical treatment. (18108700)
1948

Variations for Recurrent Acute Pancreatitis

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Expression for genes affiliated with Recurrent Acute Pancreatitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for genes affiliated with Recurrent Acute Pancreatitis

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Compounds for genes affiliated with Recurrent Acute Pancreatitis

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45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid45 24 1111.7SCT, APOE
2tetrodotoxin45 61 2911.7APOE, SCT
3thyroxine45 2410.6APOE, SCT
4guanine45 24 1111.5APOE, SCT
5formate459.5CFTR, APOE
6fluoride459.5CFTR, SPINK1
7dermatan sulfate459.5APOE, CFTR
8glibenclamide45 29 51 6112.5APOE, CFTR
9ibuprofen45 29 51 24 1113.5CFTR, APOE
10h2dids459.5SCT, CFTR
11chloroquine45 3 51 29 1113.5CFTR, APOE
12nppb29 45 6111.4SCT, CFTR
13dids45 2910.4SCT, CFTR
14suramin45 29 1111.4APOE, CFTR
15taurocholate459.4SCT, CFTR
16carbohydrates459.4CFTR, APOE
17amiloride45 29 1111.4SCT, CFTR
18bicarbonate459.4SCT, CFTR
19valine459.4CFTR, APOE
20phospholipid459.3APOE, SCT
21carbachol45 29 1111.3SCT, CFTR
22aspirin45 51 29 2412.3CFTR, APOE
23isoproterenol45 1110.3SCT, CFTR
24chloride459.2SCT, CFTR
25n acetylcysteine459.2APOE, CFTR
26epinephrine45 24 1111.1SCT, CFTR
27ascorbic acid45 2410.1CFTR, APOE
28vitamin d459.0APOE, CFTR
29trypsinogen458.9SCT, CFTR, SPINK1
30biotin45 24 1110.9CFTR, SCT, APOE
31ibmx45 61 2910.9APOE, SCT, CFTR
32indomethacin45 29 61 1111.9CFTR, SCT, APOE
33acetylcholine45 51 29 24 1112.9CFTR, SCT, APOE
34cyclosporin a45 29 6110.9APOE, SCT, CFTR
35glutamine458.9CFTR, SCT, APOE
36dopamine45 29 24 1111.9APOE, SCT, CFTR
37aspartate458.9APOE, SCT, CFTR
38testosterone45 61 24 1111.9CFTR, SCT, APOE
39glutamate458.8APOE, SCT, CFTR
40cysteine458.8CFTR, SCT, APOE
41norepinephrine45 24 1110.7SCT, CFTR
42serine458.4SPINK1, CFTR, SCT, APOE

GO Terms for genes affiliated with Recurrent Acute Pancreatitis

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16Gene Ontology
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Cellular components related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1early endosomeGO:0057698.8APOE, CFTR
2extracellular regionGO:0055768.8APOE, SCT, SPINK1

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3APOE, SCT
2vasodilationGO:0423118.8APOE, CFTR

Products for genes affiliated with Recurrent Acute Pancreatitis

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  • Antibodies
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Sources for Recurrent Acute Pancreatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet