MCID: RCR022
MIFTS: 43

Recurrent Acute Pancreatitis

Categories: Bone diseases, Immune diseases, Rare diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases

Aliases & Classifications for Recurrent Acute Pancreatitis

MalaCards integrated aliases for Recurrent Acute Pancreatitis:

Name: Recurrent Acute Pancreatitis 55
Acute Recurrent Pancreatitis 28 51 69

Characteristics:

Orphanet epidemiological data:

55
recurrent acute pancreatitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

Orphanet 55 ORPHA64740
UMLS via Orphanet 70 C0267937
ICD10 via Orphanet 33 K85.0 K85.1 K85.2 more
UMLS 69 C0267937

Summaries for Recurrent Acute Pancreatitis

MalaCards based summary : Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to acute pancreatitis and hypertriglyceridemia, familial. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lipoprotein metabolism and Metabolism of fat-soluble vitamins. The drugs Secretin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and smooth muscle, and related phenotype is Increased LDL uptake.

Related Diseases for Recurrent Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 31.0 LPL SCT SPINK1
2 hypertriglyceridemia, familial 30.0 APOE LPL
3 cystic fibrosis 29.7 CFTR PRSS1 SCT SPINK1
4 pancreatitis 29.5 CFTR CTRC LPL PRSS1 SCT SPINK1
5 pancreatitis, hereditary 27.8 CFTR CTRC LPL PRSS1 SCT SPINK1
6 autoimmune pancreatitis 10.3 CFTR PRSS1
7 pancreatic steatorrhea 10.2 PRSS1 SCT
8 steatorrhea 10.2 CFTR SCT
9 exocrine pancreatic insufficiency 10.2 CFTR SCT
10 hyperlipoproteinemia, type v 10.1 APOE LPL
11 hepatic lipase deficiency 10.1 APOE LPL
12 duodenitis 10.1
13 hyperlipoproteinemia, type iv 10.1 APOE LPL
14 homozygous familial hypercholesterolemia 10.1 APOE LPL
15 apolipoprotein c-ii deficiency 10.1 GPIHBP1 LPL
16 pancreatic agenesis 1 10.1 CFTR SCT SPINK1
17 ischemic heart disease 10.1 APOE LPL
18 hypolipoproteinemia 10.1 APOE LPL
19 familial lipoprotein lipase deficiency 10.1 GPIHBP1 LPL
20 pancreas disease 10.0 PRSS1 SCT SPINK1
21 xanthomatosis 10.0 APOE LPL
22 hyperlipoproteinemia, type iii 10.0 APOE LPL
23 fibrosis of extraocular muscles, congenital, 1 10.0
24 hyperlipidemia, familial combined 10.0 APOE LPL
25 hyperalphalipoproteinemia 1 10.0 APOE LPL
26 hypertriglyceridemia, transient infantile 10.0
27 hyperparathyroidism 10.0
28 abetalipoproteinemia 9.9 APOE LPL
29 primary hyperparathyroidism 9.9
30 gallbladder disease 9.9 APOE CFTR
31 lecithin:cholesterol acyltransferase deficiency 9.9 APOE LPL
32 tropical calcific pancreatitis 9.9 CTRC PRSS1 SPINK1
33 head injury 9.9 APOE SOD1
34 coronary heart disease 1 9.9 APOE LPL
35 adenoma 9.7
36 arteriovenous malformation 9.7
37 neuroendocrine tumor 9.7
38 gastric duplication cysts 9.7
39 intussusception 9.7
40 purpura 9.7
41 familial hyperlipidemia 9.6 APOE LPL
42 systemic lupus erythematosus 9.6
43 body mass index quantitative trait locus 7 9.6
44 cholelithiasis 9.6
45 eosinophilic gastroenteritis 9.6
46 pancreas, annular 9.6
47 body mass index quantitative trait locus 12 9.6
48 lymphoblastic leukemia 9.6
49 body mass index quantitative trait locus 14 9.6
50 thrombotic thrombocytopenic purpura 9.6

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to Recurrent Acute Pancreatitis

Symptoms & Phenotypes for Recurrent Acute Pancreatitis

GenomeRNAi Phenotypes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE LPL

Drugs & Therapeutics for Recurrent Acute Pancreatitis

Drugs for Recurrent Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Secretin Approved, Investigational Phase 3,Phase 1 108153-74-8
2
Pancrelipase Approved, Investigational Phase 3 53608-75-6
3 pancreatin Phase 3
4 Gastrointestinal Agents Phase 3,Phase 1
5 Hormone Antagonists Phase 3,Phase 1
6 Hormones Phase 3,Phase 1
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
8
Ethanol Approved 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the Pancreas Completed NCT00660335 Phase 3 RG1068 (synthetic human secretin)
2 Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population Terminated NCT00621283 Phase 1 RG1068 (Synthetic Human Secretin)
3 ERCP in Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517
4 Idiopathic Recurrent Acute Pancreatitis (IRAP) Completed NCT01133535
5 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
6 Trial of Index Cholecystectomy Versus Scheduled Cholecystectomy in Biliary Pancreatitis Completed NCT02630433
7 The North American Pancreatitis Study Completed NCT01545167
8 Decrease of Recurrent Pancreatitis Completed NCT00534534
9 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392
10 Internet-based Pain Self-management for Persons With Acute Recurrent and Chronic Pancreatitis Pain Not yet recruiting NCT03322644 Not Applicable

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

Genetic tests related to Recurrent Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis 28

Anatomical Context for Recurrent Acute Pancreatitis

MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

38
Pancreas, Testes, Smooth Muscle, Pancreatic Islet, Kidney, Spleen

Publications for Recurrent Acute Pancreatitis

Articles related to Recurrent Acute Pancreatitis:

(show top 50) (show all 189)
# Title Authors Year
1
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
2
Pancreaticoportal Fistula Formation as a Consequence of Recurrent Acute Pancreatitis: Clinical and Imaging Considerations. ( 29441227 )
2018
3
Endoscopic Placement of a U-Shaped Plastic Stent in Patients With Recurrent Acute Pancreatitis and Incomplete Pancreas Divisum. ( 29215619 )
2017
4
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
5
A Rare Etiology of Idiopathic Recurrent Acute Pancreatitis. ( 28384455 )
2017
6
Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis. ( 28611564 )
2017
7
Plasmapheresis for recurrent acute pancreatitis from hypertriglyceridemia. ( 28670087 )
2017
8
Increased oxidative stress and deficient antioxidant levels may be involved in the pathogenesis of idiopathic recurrent acute pancreatitis. ( 28687456 )
2017
9
Reply to: Yang et al, Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426494 )
2017
10
Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis. ( 28548960 )
2017
11
A rare etiology of idiopathic recurrent acute pancreatitis. ( 28355653 )
2017
12
The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis. ( 27824485 )
2017
13
R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series. ( 28196530 )
2017
14
Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426493 )
2017
15
A Rare Cause of Recurrent Acute Pancreatitis in a Child: Isovaleric Acidemia with Novel Mutation. ( 28401058 )
2017
16
Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy. ( 28596690 )
2017
17
Role of ERCP in Patients With Idiopathic Recurrent Acute Pancreatitis. ( 27371265 )
2016
18
Acute pancreatitis-induced thrombotic thrombocytopenic purpura with recurrent acute pancreatitis. ( 26905311 )
2016
19
Hyperparathyroidism as a cause of recurrent acute pancreatitis: A case report. ( 29341554 )
2016
20
Hereditary Angioedema Presenting as Recurrent Acute Pancreatitis. ( 26812927 )
2016
21
Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism. ( 27365562 )
2016
22
Transcatheter embolization of pancreatic arteriovenous malformation associated with recurrent acute pancreatitis. ( 27081231 )
2016
23
Henoch-SchAPnlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis. ( 27748349 )
2016
24
Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis. ( 27833385 )
2016
25
A rare case report on recurrent acute pancreatitis secondary to primary hyperparathyroidism. ( 27728265 )
2016
26
Recurrent acute pancreatitis in bowel malrotation. ( 27906430 )
2016
27
Recurrent acute pancreatitis caused by pancreatic biliary maljunction due to long common channel. ( 28062875 )
2016
28
Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis. ( 26892125 )
2016
29
Endoscopic sphincterotomy (ES) may not alter the natural history of idiopathic recurrent acute pancreatitis (IRAP). ( 27450967 )
2016
30
An Unusual Cause of Recurrent Acute Pancreatitis. ( 26658042 )
2016
31
Cannabis induced recurrent acute pancreatitis. ( 26519137 )
2015
32
Hepatobiliary and Pancreatic: Triad of recurrent acute pancreatitis, duodenal web and intra-pancreatic duodenal duplication cyst: a new constellation? ( 26458086 )
2015
33
A B-wildering Case of Recurrent Acute Pancreatitis. ( 26026747 )
2015
34
Endoscopic Treatment of Recurrent Acute Pancreatitis and Smoldering Acute Pancreatitis. ( 26431601 )
2015
35
Myofibroblastic Inflammatory Tumor Presenting as Recurrent Acute Pancreatitis and Obstructive Jaundice. ( 26405696 )
2015
36
Parathyroid adenoma in a young female presenting as recurrent acute pancreatitis with a brown tumour of the mandible-A case study. ( 25574767 )
2015
37
Loperamide-induced recurrent acute pancreatitis. ( 26184348 )
2015
38
Recurrent acute pancreatitis secondary to Ascaris lumbricoides. ( 25851160 )
2015
39
An unusual retroperitoneal lesion causing recurrent acute pancreatitis. ( 26273777 )
2015
40
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. ( 25569187 )
2015
41
Recurrent acute pancreatitis. ( 25262707 )
2014
42
Gastrointestinal: gastric outlet obstruction and air pancreatogram in the setting of recurrent acute pancreatitis. ( 25040618 )
2014
43
Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. ( 26012333 )
2014
44
A case of recurrent acute pancreatitis in an obese child. ( 25194617 )
2014
45
Intraductal papillary mucinous neoplasm causing recurrent acute pancreatitis, necrotizing pancreatitis, and multifocal adenocarcinoma. ( 25434666 )
2014
46
Prevention of Gastric Volvulus-induced Recurrent Acute Pancreatitis by Percutaneous Endoscopic Gastropexy. ( 25251574 )
2014
47
Saxagliptin-induced recurrent acute pancreatitis. ( 24930656 )
2014
48
Elevated Deoxycholic Acid and Idiopathic Recurrent Acute Pancreatitis: A Case Report With 48 Months of Follow-up. ( 24891995 )
2014
49
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. ( 24618449 )
2014
50
PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis. ( 25206283 )
2014

Variations for Recurrent Acute Pancreatitis

Expression for Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for Recurrent Acute Pancreatitis

Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 APOE GPIHBP1 LPL
2
Show member pathways
11.66 APOE GPIHBP1 LPL
3
Show member pathways
11.63 APOE CTRC GPIHBP1 LPL PRSS1
4
Show member pathways
11.03 CFTR SOD1
5 10.3 CTRC PRSS1

GO Terms for Recurrent Acute Pancreatitis

Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 APOE CFTR LPL PRSS1 SOD1 SPINK1
2 extracellular matrix GO:0031012 9.58 APOE LPL SOD1
3 extracellular space GO:0005615 9.43 APOE LPL PRSS1 SCT SOD1 SPINK1
4 high-density lipoprotein particle GO:0034364 9.32 APOE GPIHBP1
5 very-low-density lipoprotein particle GO:0034361 9.26 APOE LPL
6 extracellular region GO:0005576 9.23 APOE CTRC GPIHBP1 LPL PRSS1 SCT
7 chylomicron GO:0042627 9.16 APOE LPL

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.54 APOE GPIHBP1 LPL
2 triglyceride metabolic process GO:0006641 9.52 APOE LPL
3 triglyceride catabolic process GO:0019433 9.51 APOE LPL
4 sperm capacitation GO:0048240 9.49 CFTR SPINK1
5 cobalamin metabolic process GO:0009235 9.48 CTRC PRSS1
6 response to reactive oxygen species GO:0000302 9.46 APOE SOD1
7 regulation of lipoprotein lipase activity GO:0051004 9.43 GPIHBP1 LPL
8 very-low-density lipoprotein particle remodeling GO:0034372 9.4 APOE LPL
9 retinoid metabolic process GO:0001523 9.33 APOE GPIHBP1 LPL
10 negative regulation of cholesterol biosynthetic process GO:0045541 9.32 APOE SOD1
11 protein import GO:0017038 9.26 APOE GPIHBP1
12 triglyceride homeostasis GO:0070328 9.13 APOE GPIHBP1 LPL
13 chylomicron remodeling GO:0034371 8.8 APOE GPIHBP1 LPL

Molecular functions related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.96 APOE SOD1
2 lipoprotein particle binding GO:0071813 8.62 APOE GPIHBP1

Sources for Recurrent Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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