MCID: RCR022
MIFTS: 38

Recurrent Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Endocrine diseases, Bone diseases, Immune diseases categories

Aliases & Classifications for Recurrent Acute Pancreatitis

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Sources:
51Orphanet, 24GTR, 65UMLS, 47Novoseek, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Recurrent Acute Pancreatitis:

Name: Recurrent Acute Pancreatitis 51 24
 
Acute Recurrent Pancreatitis 65 47


Classifications:



Characteristics (Orphanet epidemiological data):

51
recurrent acute pancreatitis:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages


External Ids:

Orphanet51 64740
ICD10 via Orphanet28 K85.3, K85.8, K85.9 K85.0, K85.1, K85.2, more
UMLS via Orphanet66 C0267937

Summaries for Recurrent Acute Pancreatitis

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MalaCards based summary: Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to hypertriglyceridemia and cystic fibrosis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways are Statin Pathway and Pancreatic secretion. Affiliated tissues include pancreas, testes and smooth muscle, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Related Diseases for Recurrent Acute Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Cftr-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Spink1-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 recurrent acute pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hypertriglyceridemia30.4APOE, LPL
2cystic fibrosis30.3CFTR, PRSS1, SCT, SPINK1
3pancreatitis, hereditary29.6CFTR, LPL, PRSS1, SCT, SPINK1
4panniculitis29.4CFTR, LPL, PRSS1, SCT, SPINK1
5acute pancreatitis11.1
6pancreatitis11.1
7duodenitis10.6
8primary hyperparathyroidism10.3
9hyperparathyroidism10.3
10adenoma10.2
11neuroendocrine tumor10.2
12pancreas disease10.2
13gastric duplication cysts10.2
14congenital enterocyte heparan sulfate deficiency10.2CFTR, SPINK1
15familial nephrotic syndrome10.1CFTR, SCT
16tracheitis10.1CFTR, SCT
17dysentery10.1PRSS1, SPINK1
18arsacs10.1APOE, LPL
19tropical calcific pancreatitis10.1PRSS1, SPINK1
20retinal degeneration, late-onset, autosomal dominant10.1APOE, LPL
21gallbladder sarcoma10.1APOE, CFTR
22amelogenesis imperfecta, type iia310.1APOE, LPL
23duodenal obstruction10.1PRSS1, SCT
24hyperphenilalaninemia due to pterin-4-alpha-carbin10.1APOE, LPL
25arteriovenous fistula10.0APOE, LPL
26vaginal mullerian papilloma10.0PRSS1, SCT
27systemic lupus erythematosus10.0
28obesity10.0
29psoriatic arthritis10.0
30pancreatic cancer10.0
31arthritis10.0
32hepatitis10.0
33leukemia10.0
34somatostatinoma10.0
35ulcerative colitis10.0
36obstructive jaundice10.0
37sjogren's syndrome10.0
38cholelithiasis10.0
39arteriovenous malformation10.0
40intussusception10.0
41paraganglioma10.0
42inflammatory myofibroblastic tumor10.0
43villous adenoma10.0
44eosinophilic gastroenteritis10.0
45polycystic kidney disease10.0
46choledochal cyst10.0
47biliary dyskinesia10.0
48adenocarcinoma10.0
49cholangitis10.0
50colitis10.0

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to recurrent acute pancreatitis

Symptoms for Recurrent Acute Pancreatitis

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Drugs & Therapeutics for Recurrent Acute Pancreatitis

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Drugs for Recurrent Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Secretinapproved, investigationalPhase 3, Phase 129108153-74-8
Synonyms:
108153-74-8
1393-25-5
67307-60-2 (citrate (salt))
9002-77-1
EINECS 215-733-3
Hormone of the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level
Human secretin
I06-1828
L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-aspartyl-L-seryl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-glutamylglycyl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
LS-144747
RG 1068
SECREFLO
SECRETIN
SECRETIN-FERRING
 
SecreFlow
Secrepan
Secretin (human)
Secretin (porcine)
Secretin [INN:BAN:DCF:JAN]
Secretin-Kabi
Secretina
Secretina [INN-Spanish]
Secretine
Secretine [INN-French]
Secretinum
Secretinum [INN-Latin]
Secretolin
UNII-88C55N56UU
UNII-A0426J905J
Vitrum
2
PancrelipaseapprovedPhase 383953608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
3pancreatinPhase 3839
4

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Acute Pancreatitis and Acute Fluid CollectionsCompletedNCT00786929Phase 4
2Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the PancreasCompletedNCT00660335Phase 3
3Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric PopulationTerminatedNCT00621283Phase 1
4ERCP in Idiopathic Recurrent Acute PancreatitisCompletedNCT01583517
5Idiopathic Recurrent Acute Pancreatitis (IRAP)CompletedNCT01133535
6Recurrence of Acute Alcoholic PancreatitisCompletedNCT00523874
7Decrease of Recurrent PancreatitisCompletedNCT00534534
8Cytological Evaluation of Biliary Epithelium After Endoscopic SphincterotomyCompletedNCT01135732
9Trial of Index Cholecystectomy Versus Scheduled Cholecystectomy in Biliary PancreatitisRecruitingNCT02630433
10The North American Pancreatitis StudyRecruitingNCT01545167
11Optimization and Cost-effective Analysis of Secondary Biliary Stones' ManagementsRecruitingNCT02554097
12Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal DisordersRecruitingNCT01438385

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

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Genetic tests related to Recurrent Acute Pancreatitis:

id Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis24

Anatomical Context for Recurrent Acute Pancreatitis

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MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

33
Pancreas, Testes, Smooth muscle, Pancreatic islet, Kidney, Bone

Animal Models for Recurrent Acute Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Recurrent Acute Pancreatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2APOE, CFTR, LPL, SOD1
2MP:00053767.4APOE, CFTR, LPL, SCT, SOD1, SPINK1

Publications for Recurrent Acute Pancreatitis

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Articles related to Recurrent Acute Pancreatitis:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
A B-wildering Case of Recurrent Acute Pancreatitis. (26026747)
2015
2
Recurrent acute pancreatitis secondary to Ascaris lumbricoides. (25851160)
2015
3
An unusual retroperitoneal lesion causing recurrent acute pancreatitis. (26273777)
2015
4
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. (25569187)
2015
5
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. (24618449)
2014
6
Gastrointestinal: gastric outlet obstruction and air pancreatogram in the setting of recurrent acute pancreatitis. (25040618)
2014
7
Elevated Deoxycholic Acid and Idiopathic Recurrent Acute Pancreatitis: A Case Report With 48 Months of Follow-up. (24891995)
2014
8
Defining a therapeutic program for recurrent acute pancreatitis patients with unknown etiology. (24833943)
2014
9
Recurrent acute pancreatitis as a long-term complication of congenital choledochal cyst surgery. (25007026)
2014
10
PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis. (25206283)
2014
11
Recurrent acute pancreatitis in a patient with wirsungocele and neuroendocrine tumor of ampulla of Vater. (23306346)
2013
12
Roux-en-y biliary by-pass - a new approach in the treatment of hypertriglyceridemia induced recurrent acute pancreatitis. Clinical case study. (23612621)
2013
13
Gadolinium induced recurrent acute pancreatitis. (23395575)
2013
14
Recurrent acute pancreatitis and cholangitis in a patient with autosomal dominant polycystic kidney disease. (23543834)
2013
15
Recurrent acute pancreatitis: an approach to diagnosis and management. (24851521)
2013
16
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
17
Recurrent acute pancreatitis probably induced by rosuvastatin therapy: a case report. (22536267)
2012
18
Isoniazid-induced recurrent acute pancreatitis. (21873403)
2011
19
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
20
Recurrent Acute Pancreatitis and Therapy for Ulcerative Colitis. (21060690)
2010
21
SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. (19888199)
2010
22
Recurrent acute pancreatitis caused by a gastric duplication cyst communicating with an aberrant pancreatic duct. (20647650)
2010
23
Duodenal duplication cyst communicating with the main pancreatic duct. A rare cause of recurrent acute pancreatitis. (21136003)
2010
24
A Case of Recurrent Acute Pancreatitis due to Pancreatic Arteriovenous Malformation. (20479928)
2010
25
Recurrent acute pancreatitis secondary to a duodenal duplication cyst in an adult. A case report and literature review. (19893770)
2009
26
Cystic fibrosis transmembrane conductance regulator ion channel function testing in recurrent acute pancreatitis. (18360295)
2008
27
Cancer of the papilla causing recurrent acute pancreatitis and mimicking a pancreatic stone. (17285500)
2007
28
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
29
Recurrent acute pancreatitis probably secondary to lisinopril. (17233197)
2006
30
Recurrent acute pancreatitis due to a hydatid cyst of the pancreatic head: a case report and review of the literature. (16006687)
2005
31
Hereditary pancreatitis--a rare differential diagnosis in patients with menstruation-associated recurrent acute pancreatitis: a case report. (15106365)
2004
32
Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. (15307877)
2004
33
Recurrent acute pancreatitis after isoniazid. (15366703)
2004
34
Cystic fibrosis, pregnancy, and recurrent, acute pancreatitis. (12658041)
2003
35
Long-term results of endoscopic management of pancreas divisum with recurrent acute pancreatitis. (11868012)
2002
36
Cavernous pancreatic ductal ectasia with smooth muscle proliferation causing recurrent acute pancreatitis. (11876255)
2001
37
Aetiologies of recurrent acute pancreatitis: acute or chronic relapsing disease? (11880695)
2001
38
Does recurrent acute pancreatitis lead to chronic pancreatitis? Sequential morphological and biochemical studies. (9163778)
1997
39
Recurrent panniculitis as the first clinical manifestation of recurrent acute pancreatitis secondary to cholelithiasis. (8683492)
1996
40
Prevention of recurrent acute pancreatitis in patients with severe hypertriglyceridemia: value of regular plasmapheresis. (8783340)
1996
41
Recurrent acute pancreatitis as a complication of cystic fibrosis: report of one case treated surgically. (1768003)
1991
42
Recurrent acute pancreatitis--rarely idiopathic: 1989 Du Pont lecture. (2268808)
1990
43
Recurrent acute pancreatitis associated with pancreas divisum. (3337068)
1988
44
Pathophysiologic factors in recurrent acute pancreatitis. (3935840)
1985
45
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
46
Abscess of pancreas; a sequelae of recurrent acute pancreatitis. (13295462)
1955
47
Further clinical study of the effect of vagotomy on recurrent acute pancreatitis. (13118354)
1954
48
The surgical treatment of recurrent acute pancreatitis by endocholedochal sphincterotomy. (18901326)
1948
49
Recurrent acute pancreatitis; observations on etiology and surgical treatment. (18893291)
1948
50
Recurrent acute pancreatitis; observations on etiology and surgical treatment. (18108700)
1948

Variations for Recurrent Acute Pancreatitis

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Expression for genes affiliated with Recurrent Acute Pancreatitis

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Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for genes affiliated with Recurrent Acute Pancreatitis

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Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4APOE, LPL
29.4CFTR, PRSS1
3
Show member pathways
9.2CFTR, SOD1
4
Show member pathways
9.2CFTR, SOD1
5
Show member pathways
9.1APOE, SOD1

GO Terms for genes affiliated with Recurrent Acute Pancreatitis

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Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:004262710.1APOE, LPL
2very-low-density lipoprotein particleGO:003436110.1APOE, LPL
3extracellular matrixGO:00310128.7APOE, LPL, SOD1
4extracellular regionGO:00055767.5APOE, LPL, PRSS1, SCT, SOD1
5extracellular exosomeGO:00700627.2APOE, CFTR, LPL, PRSS1, SOD1, SPINK1
6extracellular spaceGO:00056156.9APOE, LPL, PRSS1, SCT, SOD1, SPINK1

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:003437210.0APOE, LPL
2lipoprotein metabolic processGO:00421579.8APOE, LPL
3cholesterol transportGO:00303019.8APOE, CFTR
4negative regulation of cholesterol biosynthetic processGO:00455419.7APOE, SOD1
5triglyceride catabolic processGO:00194339.7APOE, LPL
6triglyceride metabolic processGO:00066419.5APOE, LPL
7response to reactive oxygen speciesGO:00003029.5APOE, SOD1
8retinoid metabolic processGO:00015239.4APOE, LPL
9phototransduction, visible lightGO:00076039.3APOE, LPL
10cholesterol biosynthetic processGO:00066959.2APOE, CFTR
11negative regulation of neuron apoptotic processGO:00435248.7APOE, SCT, SOD1

Sources for Recurrent Acute Pancreatitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet