MCID: RCR022
MIFTS: 41

Recurrent Acute Pancreatitis malady

Categories: Gastrointestinal diseases, Rare diseases, Endocrine diseases, Genetic diseases, Bone diseases, Immune diseases

Aliases & Classifications for Recurrent Acute Pancreatitis

Aliases & Descriptions for Recurrent Acute Pancreatitis:

Name: Recurrent Acute Pancreatitis 56 29
Acute Recurrent Pancreatitis 52 69

Characteristics:

Orphanet epidemiological data:

56
recurrent acute pancreatitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

Orphanet 56 ORPHA64740
ICD10 via Orphanet 34 K85.9 K85.0 K85.1 more
UMLS via Orphanet 70 C0267937

Summaries for Recurrent Acute Pancreatitis

MalaCards based summary : Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to pancreatitis and acute pancreatitis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lipoprotein metabolism and Metabolism of fat-soluble vitamins. The drugs Secretin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and smooth muscle, and related phenotype is Increased LDL uptake.

Related Diseases for Recurrent Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Cftr-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Spink1-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Related Disease Score Top Affiliating Genes
1 pancreatitis 10.6
2 acute pancreatitis 10.6
3 cavernous sinus thrombosis 10.2 PRSS1 SPINK1
4 autosomal dominant intermediate charcot-marie-tooth 10.2 CFTR PRSS1
5 female stress incontinence 10.2 CFTR SCT
6 tricuspid valve insufficiency 10.2 PRSS1 SCT
7 alport syndrome and thin basement membrane nephropathy 10.1 APOE LPL
8 hyperchlorhidrosis, isolated 10.1 APOE LPL
9 c1s deficiency 10.1 APOE LPL
10 short bowel syndrome 10.1 CFTR SCT
11 fibrosis of extraocular muscles, congenital, 3c 10.1 CFTR SCT SPINK1
12 severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome 10.1 APOE LPL
13 abducens nerve neoplasm 10.1 GPIHBP1 LPL
14 joint disorders 10.1 APOE LPL
15 chondroma 10.1 PRSS1 SCT SPINK1
16 asphyxia neonatorum 10.1 APOE LPL
17 acute gonococcal cervicitis 10.1 PRSS1 SCT
18 bird fancier's lung 10.0 APOE LPL
19 skin squamous cell carcinoma 10.0 APOE LPL
20 chondrocalcinosis with early-onset osteoarthritis 10.0 APOE LPL
21 duodenitis 10.0
22 lacrimal system cancer 10.0 LPL SCT SPINK1
23 diastrophic dysplasia 10.0 CTRC PRSS1 SPINK1
24 mannosidosis, beta 10.0 APOE LPL
25 von willebrand disease, platelet-type 9.9 APOE LPL
26 hyperlysinemia 9.9 CFTR PRSS1 SCT SPINK1
27 cervical adenomyoma 9.9 CFTR LPL PRSS1 SPINK1
28 cystic fibrosis 9.9
29 bleeding disorder, east texas type 9.9 APOE LPL
30 primary congenital glaucoma 9.9 CFTR CTRC PRSS1 SPINK1
31 hyperparathyroidism 9.9
32 hypertriglyceridemia 9.8
33 pericarditis 9.7 APOE LPL SOD1
34 netherton syndrome 9.7 CFTR CTRC PRSS1 SCT SPINK1
35 gastric duplication cysts 9.7
36 arteriovenous malformation 9.7
37 adenoma 9.7
38 neuroendocrine tumor 9.7
39 purpura 9.7
40 obesity 9.5
41 cholelithiasis 9.5
42 tuberculosis 9.5
43 psoriatic arthritis 9.5
44 lymphoblastic leukemia 9.5
45 eosinophilic gastroenteritis 9.5
46 pancreatic neuroendocrine tumor 9.5
47 thrombotic thrombocytopenic purpura 9.5
48 aneurysm 9.5
49 kidney disease 9.5
50 isovaleric acidemia 9.5

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to Recurrent Acute Pancreatitis

Symptoms & Phenotypes for Recurrent Acute Pancreatitis

GenomeRNAi Phenotypes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE LPL

Drugs & Therapeutics for Recurrent Acute Pancreatitis

Drugs for Recurrent Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Secretin Approved, Investigational Phase 3,Phase 1 108153-74-8
2
Pancrelipase Approved Phase 3 53608-75-6
3 pancreatin Phase 3
4 Gastrointestinal Agents Phase 3,Phase 1
5 Hormone Antagonists Phase 3,Phase 1
6 Hormones Phase 3,Phase 1
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
8
Simvastatin Approved Phase 2 79902-63-9 54454
9
Orlistat Approved, Investigational Phase 2 96829-58-2 3034010
10 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
11 Hypolipidemic Agents Phase 2
12 Anticholesteremic Agents Phase 2
13 Lipid Regulating Agents Phase 2
14 Antimetabolites Phase 2
15 Anti-Obesity Agents Phase 2
16
Ethanol Approved 64-17-5 702
17
Midazolam Approved, Illicit 59467-70-8 4192
18
Menthol Approved 2216-51-5 16666
19
Meperidine Approved 57-42-1 4058

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4
2 Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the Pancreas Completed NCT00660335 Phase 3
3 Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis Recruiting NCT02743364 Phase 2
4 Orlistat for the Treatment of Type I Hyperlipoproteinemia Recruiting NCT02767531 Phase 2
5 Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population Terminated NCT00621283 Phase 1
6 The North American Pancreatitis Study Unknown status NCT01545167
7 ERCP in Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517
8 Idiopathic Recurrent Acute Pancreatitis (IRAP) Completed NCT01133535
9 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
10 Decrease of Recurrent Pancreatitis Completed NCT00534534
11 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
12 Trial of Index Cholecystectomy Versus Scheduled Cholecystectomy in Biliary Pancreatitis Recruiting NCT02630433
13 The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations Recruiting NCT02928718
14 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Recruiting NCT02554097
15 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
16 Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy Active, not recruiting NCT03085407
17 The LD Lync Study - Natural History Study of Genetic Lipodystrophy Syndromes Not yet recruiting NCT03087253

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

Genetic tests related to Recurrent Acute Pancreatitis:

id Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis 29

Anatomical Context for Recurrent Acute Pancreatitis

MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

39
Pancreas, Testes, Smooth Muscle, Pancreatic Islet, Kidney, Spleen

Publications for Recurrent Acute Pancreatitis

Articles related to Recurrent Acute Pancreatitis:

(show top 50) (show all 174)
id Title Authors Year
1
A Rare Cause of Recurrent Acute Pancreatitis in a Child: Isovaleric Acidemia with Novel Mutation. ( 28401058 )
2017
2
The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis. ( 27824485 )
2017
3
Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis. ( 26892125 )
2016
4
An Unusual Cause of Recurrent Acute Pancreatitis. ( 26658042 )
2016
5
Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis. ( 27833385 )
2016
6
Recurrent acute pancreatitis in bowel malrotation. ( 27906430 )
2016
7
A rare case report on recurrent acute pancreatitis secondary to primary hyperparathyroidism. ( 27728265 )
2016
8
Acute pancreatitis-induced thrombotic thrombocytopenic purpura with recurrent acute pancreatitis. ( 26905311 )
2016
9
Transcatheter embolization of pancreatic arteriovenous malformation associated with recurrent acute pancreatitis. ( 27081231 )
2016
10
Role of ERCP in Patients With Idiopathic Recurrent Acute Pancreatitis. ( 27371265 )
2016
11
Endoscopic sphincterotomy (ES) may not alter the natural history of idiopathic recurrent acute pancreatitis (IRAP). ( 27450967 )
2016
12
Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism. ( 27365562 )
2016
13
Henoch-SchAPnlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis. ( 27748349 )
2016
14
Recurrent acute pancreatitis caused by pancreatic biliary maljunction due to long common channel. ( 28062875 )
2016
15
Hereditary Angioedema Presenting as Recurrent Acute Pancreatitis. ( 26812927 )
2016
16
Hepatobiliary and Pancreatic: Triad of recurrent acute pancreatitis, duodenal web and intra-pancreatic duodenal duplication cyst: a new constellation? ( 26458086 )
2015
17
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. ( 25569187 )
2015
18
Myofibroblastic Inflammatory Tumor Presenting as Recurrent Acute Pancreatitis and Obstructive Jaundice. ( 26405696 )
2015
19
A B-wildering Case of Recurrent Acute Pancreatitis. ( 26026747 )
2015
20
An unusual retroperitoneal lesion causing recurrent acute pancreatitis. ( 26273777 )
2015
21
Endoscopic Treatment of Recurrent Acute Pancreatitis and Smoldering Acute Pancreatitis. ( 26431601 )
2015
22
Parathyroid adenoma in a young female presenting as recurrent acute pancreatitis with a brown tumour of the mandible-A case study. ( 25574767 )
2015
23
Loperamide-induced recurrent acute pancreatitis. ( 26184348 )
2015
24
Recurrent acute pancreatitis secondary to Ascaris lumbricoides. ( 25851160 )
2015
25
Cannabis induced recurrent acute pancreatitis. ( 26519137 )
2015
26
Frequency of SPINK1a88N34S mutation in acute and recurrent acute pancreatitis. ( 24844923 )
2014
27
Saxagliptin-induced recurrent acute pancreatitis. ( 24930656 )
2014
28
Intraluminal duodenal diverticulum. A rare cause of recurrent acute pancreatitis. ( 25260567 )
2014
29
Recurrent acute pancreatitis. ( 25262707 )
2014
30
PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis. ( 25206283 )
2014
31
Defining a therapeutic program for recurrent acute pancreatitis patients with unknown etiology. ( 24833943 )
2014
32
Recurrent acute pancreatitis as a long-term complication of congenital choledochal cyst surgery. ( 25007026 )
2014
33
Genetic and Electrophysiological Characteristics of Recurrent Acute Pancreatitis. ( 25383785 )
2014
34
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. ( 24618449 )
2014
35
Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. ( 26012333 )
2014
36
Gastrointestinal: gastric outlet obstruction and air pancreatogram in the setting of recurrent acute pancreatitis. ( 25040618 )
2014
37
A case of recurrent acute pancreatitis in an obese child. ( 25194617 )
2014
38
Prevention of Gastric Volvulus-induced Recurrent Acute Pancreatitis by Percutaneous Endoscopic Gastropexy. ( 25251574 )
2014
39
Intraductal papillary mucinous neoplasm causing recurrent acute pancreatitis, necrotizing pancreatitis, and multifocal adenocarcinoma. ( 25434666 )
2014
40
Elevated Deoxycholic Acid and Idiopathic Recurrent Acute Pancreatitis: A Case Report With 48 Months of Follow-up. ( 24891995 )
2014
41
Recurrent acute pancreatitis: an approach to diagnosis and management. ( 24851521 )
2013
42
Recurrent acute pancreatitis in a patient with wirsungocele and neuroendocrine tumor of ampulla of Vater. ( 23306346 )
2013
43
Anatomic pathways of peripancreatic fluid draining to mediastinum in recurrent acute pancreatitis: visible human project and CT study. ( 23614005 )
2013
44
Gadolinium induced recurrent acute pancreatitis. ( 23395575 )
2013
45
Roux-en-y biliary by-pass - a new approach in the treatment of hypertriglyceridemia induced recurrent acute pancreatitis. Clinical case study. ( 23612621 )
2013
46
A patient with pancreas divisum, recurrent acute pancreatitis, and homozygosity for the cystic fibrosis transmembrane regulator-associated protein 5T allele. ( 23416327 )
2013
47
Recurrent acute pancreatitis and cholangitis in a patient with autosomal dominant polycystic kidney disease. ( 23543834 )
2013
48
Case report: recurrent acute pancreatitis secondary to papillary somatostatinoma--a new association. ( 23561978 )
2013
49
6-Mercaptopurine-induced recurrent acute pancreatitis in children with acute lymphoblastic leukemia/lymphoma. ( 23138114 )
2013
50
Recurrent acute pancreatitis and massive hemorrhagic ascites secondary to a duodenal duplication in a child: a case report. ( 23497458 )
2013

Variations for Recurrent Acute Pancreatitis

Expression for Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for Recurrent Acute Pancreatitis

Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 APOE GPIHBP1 LPL
2
Show member pathways
11.66 APOE GPIHBP1 LPL
3
Show member pathways
11.63 APOE CTRC GPIHBP1 LPL PRSS1
4
Show member pathways
11.2 APOE LPL
5
Show member pathways
11.03 CFTR SOD1
6 10.3 CTRC PRSS1

GO Terms for Recurrent Acute Pancreatitis

Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 APOE CFTR LPL PRSS1 SOD1 SPINK1
2 extracellular matrix GO:0031012 9.58 APOE LPL SOD1
3 extracellular space GO:0005615 9.43 APOE LPL PRSS1 SCT SOD1 SPINK1
4 high-density lipoprotein particle GO:0034364 9.32 APOE GPIHBP1
5 very-low-density lipoprotein particle GO:0034361 9.26 APOE LPL
6 extracellular region GO:0005576 9.23 APOE CTRC GPIHBP1 LPL PRSS1 SCT
7 chylomicron GO:0042627 9.16 APOE LPL

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.58 APOE GPIHBP1 LPL
2 triglyceride metabolic process GO:0006641 9.52 APOE LPL
3 triglyceride catabolic process GO:0019433 9.51 APOE LPL
4 cobalamin metabolic process GO:0009235 9.49 CTRC PRSS1
5 response to reactive oxygen species GO:0000302 9.48 APOE SOD1
6 regulation of lipoprotein lipase activity GO:0051004 9.46 GPIHBP1 LPL
7 very-low-density lipoprotein particle remodeling GO:0034372 9.43 APOE LPL
8 retinoid metabolic process GO:0001523 9.43 APOE GPIHBP1 LPL
9 negative regulation of cholesterol biosynthetic process GO:0045541 9.37 APOE SOD1
10 lipoprotein metabolic process GO:0042157 9.33 APOE GPIHBP1 LPL
11 protein import GO:0017038 9.32 APOE GPIHBP1
12 triglyceride homeostasis GO:0070328 9.13 APOE GPIHBP1 LPL
13 chylomicron remodeling GO:0034371 8.8 APOE GPIHBP1 LPL

Molecular functions related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.96 APOE SOD1
2 lipoprotein particle binding GO:0071813 8.62 APOE GPIHBP1

Sources for Recurrent Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....