MCID: RCR001
MIFTS: 35

Recurrent Corneal Erosion malady

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

Aliases & Descriptions for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 14
Recurrent Erosion of Cornea 12 69
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD10 33 H18.83
ICD9CM 35 371.42
UMLS 69 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to epithelial recurrent erosion dystrophy and corneal dystrophy, avellino type. An important gene associated with Recurrent Corneal Erosion is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Ophthalmic Solutions and Tetrahydrozoline have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 71 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
id Related Disease Score Top Affiliating Genes
1 epithelial recurrent erosion dystrophy 11.2
2 corneal dystrophy, avellino type 11.0
3 corneal dystrophy, lattice type iiia 11.0
4 lacrimal apparatus disease 10.2 CXCL8 IL1B
5 chancroid 10.2 CXCL8 IL1B
6 amyotrophic lateral sclerosis type 14 10.2 CXCL8 IL1B
7 parkinson disease 11 10.2 CXCL8 IL1B
8 senile reticular retinal degeneration 10.2 CXCL8 IL1B
9 hidradenitis 10.2 CXCL8 IL1B
10 wilkes stevenson syndrome 10.2 CXCL8 IL1B
11 ovarian cystic teratoma 10.2 CXCL8 IL1B
12 nasal cavity cancer 10.1 CXCL8 IL1B
13 neonatal hypoxic and ischemic brain injury 10.1 CXCL8 IL6
14 thymic neuroendocrine carcinoma 10.1 CXCL8 IL6
15 psychotic disorder 10.1 CXCL8 IL6
16 schwannoma of ureter 10.1 CXCL8 IL6
17 retinal vascular disease 10.1 CXCL8 IL6
18 acute panmyelosis with myelofibrosis 10.1 CXCL8 IL6
19 labyrinthine bilateral reactive loss 10.1 CXCL8 IL6
20 esophagus lymphoma 10.1 CXCL8 IL6
21 childhood central nervous system mixed germ cell tumor 10.1 CXCL8 IL1B
22 larynx carcinoma in situ 10.1 CXCL8 IL6
23 stomatitis 10.1 CXCL8 IL6
24 skin conditions 10.1 CXCL8 IL1B
25 vitreoretinopathy, neovascular inflammatory 10.1 CXCL8 IL6
26 trichomalacia 10.1 CXCL8 IL6
27 cicatricial lagophthalmos 10.1 CXCL8 IL6
28 childhood intracortical osteosarcoma 10.1 CXCL8 IL1B
29 lateral cystocele 10.1 CXCL8 IL6
30 gastric dilatation 10.1 CXCL8 IL6
31 cowpox 10.1 CXCL8 IL1B
32 fallopian tube serous adenocarcinoma 10.1 CXCL8 IL6
33 orthostatic proteinuria 10.1 CXCL8 IL6
34 balkan nephropathy 10.1 CXCL8 IL1B
35 erb-duchenne and dejerine-klumpke palsies 10.1 CXCL8 IL6
36 mixed mineral dust pneumoconiosis 10.1 CXCL8 IL6
37 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.1 CXCL8 IL1B
38 anal paget's disease 10.1 IL1B IL6
39 laryngotracheoesophageal cleft type 2 10.1 IL1B IL6
40 glucosephosphate dehydrogenase deficiency 10.1 IL1B IL6
41 bipolar i disorder 10.1 IL1B IL6
42 retinal vascular occlusion 10.1 CXCL8 IL1B
43 allergic bronchopulmonary aspergillosis 10.1 CXCL8 IL6
44 human immunodeficiency virus infectious disease 10.1 IL1B IL6
45 tinea capitis 10.1 IL1B IL6
46 measles 10.1 IL1B IL6
47 dextrocardia 10.1 IL1B IL6
48 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL1B IL6
49 steroid dehydrogenase deficiency dental anomalies 10.1 IL1B IL6
50 gastric leiomyoma 10.1 IL1B IL6

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4
2 Tetrahydrozoline Phase 4
3
Ephedrine Approved 299-42-3 9294
4
Pseudoephedrine Approved 90-82-4 7028
5 Autonomic Agents
6 Lubricant Eye Drops
7 Nasal Decongestants
8 Peripheral Nervous System Agents
9 Pharmaceutical Solutions
10 Respiratory System Agents
11 Vasoconstrictor Agents
12 Dextrans

Interventional clinical trials:


id Name Status NCT ID Phase
1 Phototherapeutic Keratectomy (PTK) on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Umbilical Cord Serum Eye Drops Completed NCT01016158
5 Study of Dehydrex in Patients With Corneal Erosion Completed NCT00029185
6 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

39
Eye

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 79)
id Title Authors Year
1
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. ( 26932827 )
2016
2
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. ( 26786512 )
2016
3
Optical coherence tomography findings in recurrent corneal erosion syndrome. ( 25532997 )
2015
4
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. ( 26203756 )
2015
5
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. ( 25900814 )
2015
6
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. ( 26203746 )
2015
7
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. ( 24699561 )
2014
8
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. ( 24439438 )
2014
9
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 23759442 )
2014
10
Microbiological Study of Therapeutic Soft Contact Lenses Used in the Treatment of Recurrent Corneal Erosion Syndrome. ( 25230080 )
2014
11
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352599 )
2014
12
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352600 )
2014
13
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. ( 23974885 )
2013
14
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. ( 23821953 )
2013
15
Interventions for recurrent corneal erosion: a Cochrane Systematic review. ( 23989116 )
2013
16
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. ( 23230823 )
2013
17
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. ( 23989120 )
2013
18
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
19
Recurrent Corneal Erosion Syndrome. ( 26107728 )
2012
20
Franceschetti hereditary recurrent corneal erosion. ( 22402249 )
2012
21
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. ( 22180150 )
2012
22
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. ( 20847650 )
2011
23
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. ( 20337327 )
2010
24
Recurrent corneal erosions and epithelial basement membrane dystrophy. ( 20724847 )
2010
25
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. ( 20606026 )
2010
26
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. ( 19648776 )
2009
27
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. ( 19816187 )
2009
28
Recurrent corneal erosion syndrome. ( 19026329 )
2008
29
Recurrent corneal erosion syndrome. ( 18191654 )
2008
30
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. ( 19093010 )
2008
31
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. ( 18290949 )
2008
32
Recurrent corneal erosion: characteristics and management options. ( 18306941 )
2007
33
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. ( 17926110 )
2007
34
Recurrent corneal erosion. ( 17908600 )
2007
35
Small spot phototherapeutic keratectomy for recurrent corneal erosion. ( 17912944 )
2007
36
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. ( 17301117 )
2007
37
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. ( 18043199 )
2007
38
The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. ( 16604052 )
2006
39
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. ( 17172888 )
2006
40
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). ( 16361033 )
2005
41
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15721675 )
2005
42
Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. ( 16219742 )
2005
43
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. ( 15183802 )
2004
44
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15030848 )
2004
45
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. ( 14765101 )
2004
46
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. ( 12613981 )
2002
47
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. ( 11864879 )
2002
48
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. ( 11438047 )
2001
49
Recurrent corneal erosion after laser in situ keratomileusis. ( 11248819 )
2001
50
Phototherapeutic keratectomy for treatment of recurrent corneal erosion. ( 10609204 )
1999

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CXCL8 IL1B IL6
2
Show member pathways
12.59 CXCL8 IL1B IL6
3
Show member pathways
12.53 CXCL8 IL1B IL6
4
Show member pathways
12.48 CXCL8 IL1B IL6
5
Show member pathways
12.11 CXCL8 IL1B IL6
6
Show member pathways
12.04 CXCL8 IL1B IL6
7
Show member pathways
11.95 CXCL8 IL1B IL6
8 11.94 CXCL8 IL1B IL6
9
Show member pathways
11.92 CXCL8 IL1B IL6
10 11.78 CXCL8 IL1B IL6
11 11.74 CXCL8 IL1B IL6
12 11.7 CXCL8 IL1B IL6
13
Show member pathways
11.65 CXCL8 IL6
14 11.65 CXCL8 IL1B IL6
15 11.62 CXCL8 IL1B IL6
16 11.59 CXCL8 IL6
17 11.56 CXCL8 IL1B IL6
18 11.55 IL1B IL6
19 11.51 CXCL8 IL1B IL6
20 11.48 CXCL8 IL6
21 11.43 CXCL8 IL1B IL6
22 11.4 CXCL8 IL6
23 11.36 CXCL8 IL6
24 11.33 IL1B IL6
25 11.3 IL1B IL6
26 11.3 CXCL8 IL1B IL6
27
Show member pathways
11.23 CXCL8 IL1B IL6
28 11.18 IL1B IL6
29 11.18 IL1B IL6
30 11.17 IL1B IL6
31 11.15 CXCL8 IL6
32 11.12 IL1B IL6
33 11.1 IL1B IL6
34 11.08 IL1B IL6
35 11.07 CXCL8 IL1B IL6
36 10.99 CXCL8 IL1B IL6
37 10.87 CXCL8 IL6
38 10.82 CXCL8 IL1B IL6
39 10.75 IL1B IL6
40 10.49 CXCL8 IL1B IL6

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DNAJC9 IL1B IL6 TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 CXCL8 IL1B IL6
2 cellular response to interleukin-1 GO:0071347 9.43 CXCL8 IL6
3 negative regulation of cell proliferation GO:0008285 9.43 CXCL8 IL1B IL6
4 neutrophil chemotaxis GO:0030593 9.37 CXCL8 IL1B
5 inflammatory response GO:0006954 9.33 CXCL8 IL1B IL6
6 positive regulation of T cell proliferation GO:0042102 9.32 IL1B IL6
7 positive regulation of interleukin-6 production GO:0032755 8.96 IL1B IL6
8 positive regulation of nitric oxide biosynthetic process GO:0045429 8.62 IL1B IL6

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL6

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....