MCID: RCR001
MIFTS: 36

Recurrent Corneal Erosion malady

Summaries for Recurrent Corneal Erosion

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Wikipedia:63 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

MalaCards based summary: Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to corneal dystrophy and muckle-wells syndrome. An important gene associated with Recurrent Corneal Erosion is KRT12 (keratin 12), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cell adhesion ECM remodeling. The compounds bis(2-chloroethyl)sulfide and muramyl tripeptide phosphatidylethanolamine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Recurrent Corneal Erosion

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Recurrent Corneal Erosion, Aliases & Descriptions:

Name: Recurrent Corneal Erosion 9 11
Recurrent Erosion of Cornea 9 60
 
Recurrent Erosion Syndrome 9


External Ids:

Disease Ontology9 DOID:11541
ICD9CM27 371.42

Related Diseases for Recurrent Corneal Erosion

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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy31.0KRT12, TGFBI
2muckle-wells syndrome10.4IL1B
3intervertebral disc disease10.4IL1B
4periodontal disease10.3IL6
5conjunctivochalasis10.3MMP9
6corneal disease10.3TGFBI, KRT12
7abdominal aortic aneurysm10.2MMP9
8keratoconus10.2KRT12, TGFBI
9euthyroid sick syndrome10.2IL6, IL1B
10poems syndrome10.2IL6, IL1B
11insensitivity to pain, congenital, with anhidrosis10.2
12mitochondrial dna depletion syndrome 610.2
13corneal dystrophy, lattice type i10.2
14corneal dystrophy, epithelial basement membrane10.2
15insulin-like growth factor i10.2
16lymphedema-distichiasis syndrome10.2
17cystinosis, nephropathic10.2
18ifap syndrome with or without bresheck syndrome10.2
19keratitis-ichthyosis-deafness syndrome10.2
20ladd syndrome10.2
21dysautonomia, familial10.2
22macular corneal dystrophy10.2
23lattice corneal dystrophy10.2
24cystinosis10.2
25astigmatism10.2
26corneal deposit10.2
27corneal edema10.2
28kleeblattschaedel syndrome10.2
29eye disease10.1IL1B, IL6
30viral meningitis10.1IL6, IL8
31respiratory failure10.1IL6, IL1B
32bacterial vaginosis10.1IL1B, IL8
33bacterial meningitis10.1IL1B, IL8
34mastitis10.1IL8, IL1B
35thrombocytosis10.1IL6, IL1B
36acquired immunodeficiency syndrome10.1IL1B, IL6
37peritonitis10.1IL1B, IL6
38brain disease10.0IL6, IL1B
39interstitial lung disease10.0IL1B, MMP9
40acute pancreatitis10.0IL8, IL6
41hypersensitivity reaction type ii disease10.0IL1B, IL6
42vernal keratoconjunctivitis10.0IL8, MMP9
43synovitis9.9IL8, IL6, IL1B
44microvascular complications of diabetes 19.9MMP9, IL8
45chorioamnionitis9.9IL1B, IL6, IL8
46acute respiratory distress syndrome9.9IL8, IL6, IL1B
47monocytic leukemia9.9IL1B, IL6, IL8
48colitis9.9IL1B, IL6, IL8
49gastritis9.9IL1B, IL8
50endometriosis9.9IL8, IL6, IL1B

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to recurrent corneal erosion

Symptoms for Recurrent Corneal Erosion

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Drugs & Therapeutics for Recurrent Corneal Erosion

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Drug clinical trials:

Search ClinicalTrials for Recurrent Corneal Erosion

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

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Anatomical Context for Recurrent Corneal Erosion

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MalaCards organs/tissues related to Recurrent Corneal Erosion:

31
Eye

Animal Models for Recurrent Corneal Erosion or affiliated genes

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MGI Mouse Phenotypes related to Recurrent Corneal Erosion:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL1B, IL6, MMP9, TGFBI
2MP:00053878.1IL1B, IL6, IL8, MMP9, TGFBI
3MP:00053977.8TGFBI, MMP9, IL8, IL6, IL1B

Publications for Recurrent Corneal Erosion

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Articles related to Recurrent Corneal Erosion:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. (25900814)
2015
2
Optical coherence tomography findings in recurrent corneal erosion syndrome. (25532997)
2015
3
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352600)
2014
4
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (23759442)
2014
5
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. (24699561)
2014
6
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352599)
2014
7
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. (23230823)
2013
8
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. (23989120)
2013
9
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. (23132456)
2013
10
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (23821953)
2013
11
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. (22180150)
2012
12
Franceschetti hereditary recurrent corneal erosion. (22402249)
2012
13
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. (20847650)
2011
14
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. (20337327)
2010
15
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. (19648776)
2009
16
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. (18290949)
2008
17
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. (19093010)
2008
18
Recurrent corneal erosion syndrome. (19026329)
2008
19
Recurrent corneal erosion syndrome. (18191654)
2008
20
Recurrent corneal erosion. (17908600)
2007
21
Small spot phototherapeutic keratectomy for recurrent corneal erosion. (17912944)
2007
22
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. (17301117)
2007
23
Recurrent corneal erosion: characteristics and management options. (18306941)
2007
24
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. (17172888)
2006
25
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. (14765101)
2004
26
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. (15183802)
2004
27
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15030848)
2004
28
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. (11438047)
2001
29
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. (10235563)
1999
30
Recurrent corneal erosion syndrome. (10535864)
1999
31
Combined PRK and PTK in myopic patients with recurrent corneal erosion. (9290367)
1997
32
Corneal topographic lagoons: a potential new marker for post-traumatic recurrent corneal erosion syndrome. (8743001)
1996
33
The natural history and management of recurrent corneal erosion: a prospective randomised trial. (8013716)
1994
34
Excimer laser phototherapeutic keratectomy for treatment of recurrent corneal erosion. (8201570)
1994
35
Recurrent corneal erosion: clinical features. (7821454)
1994
36
Recurrent corneal erosion in cystinosis. (7807309)
1994
37
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (1992755)
1991
38
Recurrent corneal erosion: pathology of corneal puncture. (1935141)
1991
39
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (2220975)
1990
40
Recurrent corneal erosion. (2803088)
1989
41
Non-traumatic recurrent corneal erosion. A study based on sequential photomacrographic recordings. (3501223)
1987
42
The treatment of recurrent corneal erosion. (3820505)
1987
43
Recurrent corneal erosion, microcystic epithelial dystrophy, map configurations and fingerprint lines in the cornea. (3490898)
1986
44
Recurrent corneal erosion after trauma: a statistical study. (4062156)
1985
45
Posttraumatic recurrent corneal erosion, #2. Ultrastructural findings in epithelium and stroma. (6621361)
1983
46
Posttraumatic recurrent corneal erosion. 1. Clinical and histological studies. (7185021)
1982
47
Inherited recurrent corneal erosion. (6985236)
1981
48
Using a bandage contact lens to prevent recurrent corneal erosion during photocoagulation in patients with diabetes. (7197882)
1981
49
Treatment of recurrent corneal erosion and corneal edema with topical osmotic colloidal solution. (6172765)
1981
50
Recurrent corneal erosion. (4544649)
1973

Variations for Recurrent Corneal Erosion

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Expression for genes affiliated with Recurrent Corneal Erosion

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Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for genes affiliated with Recurrent Corneal Erosion

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Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, MMP9
2
Show member pathways
Metalloproteases in connective tissue degradation
9.5IL8, MMP9
39.4IL1B, IL6
49.4IL1B, IL6
5
Show member pathways
9.4IL1B, IL6
69.4IL1B, IL6
7
Show member pathways
IL27-mediated signaling events36
9.4IL1B, IL6
89.4IL1B, IL6
9
Show member pathways
thioredoxin pathway36
9.4IL1B, IL6
109.4IL6, IL1B
119.4IL6, IL1B
129.4IL6, IL1B
139.4IL8, IL6
149.4IL6, IL8
159.4IL6, IL8
169.4IL8, IL6
17
Show member pathways
9.4IL8, IL6
189.3IL6, MMP9
19
Show member pathways
9.0IL1B, IL6, IL8
20
Show member pathways
9.0IL1B, IL6, IL8
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0IL1B, IL6, IL8
229.0IL8, IL6, IL1B
23
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0IL1B, IL6, IL8
249.0IL8, IL6, IL1B
259.0IL8, IL6, IL1B
269.0IL8, IL6, IL1B
279.0IL1B, IL6, IL8
28
Show member pathways
Immune response MIF in innate immunity response58
9.0IL1B, IL6, IL8
29
Show member pathways
9.0IL8, IL6, IL1B
309.0IL1B, IL6, IL8
319.0IL8, IL6, IL1B
329.0IL1B, IL6, IL8
33
Show member pathways
9.0IL1B, IL6, IL8
348.9MMP9, IL6, IL1B
358.9MMP9, IL8, IL6
368.9MMP9, IL8, IL6
378.9IL6, IL8, MMP9
388.9IL6, IL8, MMP9
39
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5MMP9, IL8, IL6, IL1B
408.5IL1B, IL6, IL8, MMP9

Compounds for genes affiliated with Recurrent Corneal Erosion

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Compounds related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide439.9IL1B, IL8
2muramyl tripeptide phosphatidylethanolamine439.7IL1B, IL6
3emedastine43 1210.7IL6, IL8
4turpentine439.6IL1B, IL6
5tepoxalin439.6IL8, IL6
6survanta439.5IL8, IL1B
7fluticasone propionate43 49 59 1212.5MMP9, IL8, IL1B
8ns 39843 5910.5MMP9, IL1B, IL8
9taurine chloramine439.4IL1B, IL6, IL8
10hbd2439.4IL6, IL8, IL1B
11mip 1alpha439.4IL1B, IL6, IL8
12il-12439.4IL8, IL1B, IL6
13tpck439.4IL6, IL8, IL1B
14sivelestat439.4IL6, IL8
15polymyxin b439.4IL6, IL1B, IL8
16groalpha439.4IL6, IL8, IL1B
17anaphylatoxin439.4IL8, IL6, IL1B
18triptolide439.4IL8, IL1B, IL6
19gm-csf43 2810.4IL1B, IL6, IL8
20lipoteichoic acid439.4IL8, IL6, IL1B
21helenalin439.4MMP9, IL6, IL1B
22polyinosinic-polycytidylic acid439.3IL8, IL1B, IL6
23etanercept43 49 1211.3IL1B, IL8, IL6
24poly(i-c)439.3IL8, IL6, IL1B
25gabexate mesilate439.3IL6, IL8, MMP9
26il 10439.3IL1B, IL6, IL8
27peptidoglycan43 2810.3IL6, IL1B, IL8
28parthenolide43 210.3IL6, IL8, MMP9
298-isoprostane439.2IL6, MMP9, IL8
30pentoxifylline43 1210.2IL8, IL6, IL1B
31ivig439.2IL1B, MMP9, IL6
32neopterin439.1IL1B, IL6, IL8
3315-deoxy-delta-12,14-prostaglandin j2439.1IL6, IL8, IL1B
34ciglitazone43 289.9MMP9, IL1B, IL6, IL8
35ccl343 289.9IL1B, MMP9, IL8, IL6
36pdtc438.9IL8, IL6, MMP9, IL1B
37leukotriene b443 59 2410.9IL6, IL1B, MMP9, IL8
38sp 60012543 599.9IL1B, IL6, IL8, MMP9
39troglitazone43 28 59 1211.9IL1B, IL8, IL6, MMP9
40herbimycin a43 599.9IL1B, IL6, MMP9, IL8
41hyaluronic acid43 249.9MMP9, IL1B, IL8, IL6
42curcumin438.9IL8, IL1B, IL6, MMP9
43aprotinin43 129.9IL8, IL6, MMP9
44rantes438.8IL6, IL1B, IL8, MMP9
45n acetylcysteine438.8MMP9, IL6, IL1B, IL8
46sb 20358043 599.8IL6, IL1B, IL8, MMP9
47pd 98,059438.7IL1B, MMP9, IL8, IL6
48ly294002438.7IL1B, IL6, IL8, MMP9
49actinomycin d438.5MMP9, IL1B, IL6, IL8
50genistein43 28 59 2 24 1213.2IL1B, MMP9, IL8, IL6

GO Terms for genes affiliated with Recurrent Corneal Erosion

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Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1MMP9, IL8, IL6, IL1B, TGFBI
2extracellular spaceGO:00056157.8IL1B, IL6, IL8, MMP9, TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00075669.7IL1B, MMP9
2neutrophil chemotaxisGO:00305939.6IL8, IL1B
3positive regulation of nitric oxide biosynthetic processGO:00454299.6IL1B, IL6
4positive regulation of interleukin-6 productionGO:00327559.3IL1B, IL6
5positive regulation of T cell proliferationGO:00421029.1IL1B, IL6
6inflammatory responseGO:00069549.1IL1B, IL6, IL8
7negative regulation of cell proliferationGO:00082859.0IL1B, IL6, IL8

Products for genes affiliated with Recurrent Corneal Erosion

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Sources for Recurrent Corneal Erosion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet