MCID: RCR001
MIFTS: 43

Recurrent Corneal Erosion malady

Eye diseases category

Summaries for Recurrent Corneal Erosion

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66Wikipedia, 34MalaCards
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Wikipedia:66 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

MalaCards: Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to corneal dystrophy and lattice corneal dystrophy. An important gene associated with Recurrent Corneal Erosion is KRT12 (keratin 12), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cell adhesion ECM remodeling. The compounds bis(2-chloroethyl)sulfide and muramyl tripeptide phosphatidylethanolamine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Recurrent Corneal Erosion

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

recurrent corneal erosion 9 11
recurrent erosion of cornea 9 63
recurrent erosion syndrome 9
recurrence 63


External Ids:

Disease Ontology9 DOID:11541
ICD9CM28 371.42

Related Diseases for Recurrent Corneal Erosion

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy30.7KRT12, TGFBI
2lattice corneal dystrophy10.2
3cystinosis10.2
4astigmatism10.2
5corneal deposit10.2
6corneal edema10.2
7muckle-wells syndrome10.1IL1B
8degenerative disc disease10.1IL1B
9periodontal disease10.1IL6
10conjunctivochalasis10.1MMP9
11corneal disease10.1KRT12, TGFBI
12amyloid tumor10.1KRT12, TGFBI
13abdominal aortic aneurysm10.1MMP9
14keratoconus10.1TGFBI, KRT12
15euthyroid sick syndrome10.0IL6, IL1B
16poems syndrome10.0IL6, IL1B
17eye disease10.0IL1B, IL6
18viral meningitis10.0IL6, IL8
19respiratory failure10.0IL1B, IL6
20bacterial vaginosis10.0IL8, IL1B
21bacterial meningitis10.0IL8, IL1B
22mastitis10.0IL8, IL1B
23thrombocytosis10.0IL6, IL1B
24acquired immunodeficiency syndrome10.0IL1B, IL6
25peritonitis10.0IL6, IL1B
26prion disease10.0IL1B, IL6
27interstitial lung disease10.0MMP9, IL1B
28acute pancreatitis10.0IL6, IL8
29hypersensitivity reaction type ii disease10.0IL6, IL1B
30vernal keratoconjunctivitis10.0MMP9, IL8
31proliferative diabetic retinopathy10.0MMP9, IL8
32synovitis10.0IL1B, IL6, IL8
33chorioamnionitis10.0IL8, IL1B, IL6
34adult respiratory distress syndrome10.0IL1B, IL6, IL8
35newborn respiratory distress syndrome10.0IL6, IL1B, IL8
36monocytic leukemia10.0IL6, IL1B, IL8
37septic shock10.0IL8, IL1B, IL6
38endometriosis10.0IL8, IL6, IL1B
39gastritis10.0IL8, IL1B
40pneumonia10.0IL8, IL1B, IL6
41vascular disease10.0IL6, IL8, IL1B
42ulcerative colitis10.0IL1B, IL8, IL6
43sepsis10.0IL1B, IL8, IL6
44inflammatory bowel disease10.0IL6, IL1B, IL8
45psoriasis10.0IL8, IL1B, IL6
46skin disease10.0IL6, IL1B, MMP9
47congenital heart disease10.0MMP9, IL6, IL1B
48periodontitis10.0MMP9, IL8, IL1B
49viral infectious disease10.0IL8, IL6, IL1B
50idiopathic pulmonary fibrosis10.0IL8, IL1B, MMP9

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to recurrent corneal erosion

Symptoms for Recurrent Corneal Erosion

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Drugs & Therapeutics for Recurrent Corneal Erosion

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Recurrent Corneal Erosion

Search CenterWatch for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

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Anatomical Context for Recurrent Corneal Erosion

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34MalaCards
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MalaCards organs/tissues related to Recurrent Corneal Erosion:

34
Eye

Animal Models for Recurrent Corneal Erosion or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Recurrent Corneal Erosion:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL1B, IL6, MMP9, TGFBI
2MP:00053878.1IL1B, IL6, IL8, MMP9, TGFBI
3MP:00053977.8TGFBI, MMP9, IL8, IL6, IL1B

Publications for Recurrent Corneal Erosion

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53PubMed
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Articles related to Recurrent Corneal Erosion:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352600)
2014
2
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (23759442)
2014
3
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352599)
2014
4
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. (23230823)
2013
5
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. (23989120)
2013
6
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. (23132456)
2013
7
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (23821953)
2013
8
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. (22180150)
2012
9
Franceschetti hereditary recurrent corneal erosion. (22402249)
2012
10
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. (20847650)
2011
11
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. (20337327)
2010
12
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. (19648776)
2009
13
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. (18290949)
2008
14
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. (19093010)
2008
15
Recurrent corneal erosion syndrome. (19026329)
2008
16
Recurrent corneal erosion syndrome. (18191654)
2008
17
Recurrent corneal erosion. (17908600)
2007
18
Small spot phototherapeutic keratectomy for recurrent corneal erosion. (17912944)
2007
19
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. (17301117)
2007
20
Recurrent corneal erosion: characteristics and management options. (18306941)
2007
21
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. (17172888)
2006
22
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. (14765101)
2004
23
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. (15183802)
2004
24
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15030848)
2004
25
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. (12613981)
2002
26
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. (11438047)
2001
27
Recurrent corneal erosion after laser in situ keratomileusis. (11248819)
2001
28
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. (10235563)
1999
29
Recurrent corneal erosion syndrome. (10535864)
1999
30
Phototherapeutic keratectomy for treatment of recurrent corneal erosion. (10609204)
1999
31
Combined PRK and PTK in myopic patients with recurrent corneal erosion. (9290367)
1997
32
Corneal topographic lagoons: a potential new marker for post-traumatic recurrent corneal erosion syndrome. (8743001)
1996
33
The natural history and management of recurrent corneal erosion: a prospective randomised trial. (8013716)
1994
34
Excimer laser phototherapeutic keratectomy for treatment of recurrent corneal erosion. (8201570)
1994
35
Recurrent corneal erosion: clinical features. (7821454)
1994
36
Recurrent corneal erosion in cystinosis. (7807309)
1994
37
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (1992755)
1991
38
Recurrent corneal erosion: pathology of corneal puncture. (1935141)
1991
39
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (2220975)
1990
40
Recurrent corneal erosion. (2803088)
1989
41
Non-traumatic recurrent corneal erosion. A study based on sequential photomacrographic recordings. (3501223)
1987
42
The treatment of recurrent corneal erosion. (3820505)
1987
43
Recurrent corneal erosion, microcystic epithelial dystrophy, map configurations and fingerprint lines in the cornea. (3490898)
1986
44
Recurrent corneal erosion after trauma: a statistical study. (4062156)
1985
45
Posttraumatic recurrent corneal erosion, #2. Ultrastructural findings in epithelium and stroma. (6621361)
1983
46
Posttraumatic recurrent corneal erosion. 1. Clinical and histological studies. (7185021)
1982
47
Inherited recurrent corneal erosion. (6985236)
1981
48
Using a bandage contact lens to prevent recurrent corneal erosion during photocoagulation in patients with diabetes. (7197882)
1981
49
Treatment of recurrent corneal erosion and corneal edema with topical osmotic colloidal solution. (6172765)
1981
50
Recurrent corneal erosion. (4544649)
1973

Variations for Recurrent Corneal Erosion

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Expression for genes affiliated with Recurrent Corneal Erosion

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for genes affiliated with Recurrent Corneal Erosion

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 13EMD Millipore, 31KEGG, 55R&D Systems, 54QIAGEN, 56Reactome
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Pathways related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, MMP9
2
Show member pathways
9.5IL8, MMP9
39.4IL1B, IL6
49.4IL1B, IL6
5
Show member pathways
9.4IL1B, IL6
69.4IL1B, IL6
7
Show member pathways
IL27-mediated signaling events39
9.4IL1B, IL6
89.4IL1B, IL6
9
Show member pathways
thioredoxin pathway39
9.4IL1B, IL6
109.4IL6, IL1B
119.4IL6, IL1B
129.4IL6, IL1B
139.4IL8, IL6
149.4IL6, IL8
159.4IL6, IL8
169.4IL8, IL6
17
Show member pathways
9.4IL8, IL6
189.3IL6, MMP9
19
Show member pathways
9.0IL1B, IL6, IL8
20
Show member pathways
9.0IL1B, IL6, IL8
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.0IL1B, IL6, IL8
229.0IL8, IL6, IL1B
23
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.0IL1B, IL6, IL8
249.0IL8, IL6, IL1B
259.0IL1B, IL6, IL8
269.0IL8, IL6, IL1B
279.0IL8, IL6, IL1B
289.0IL1B, IL6, IL8
29
Show member pathways
Immune response MIF in innate immunity response61
9.0IL1B, IL6, IL8
30
Show member pathways
9.0IL8, IL6, IL1B
319.0IL1B, IL6, IL8
329.0IL8, IL6, IL1B
339.0IL1B, IL6, IL8
34
Show member pathways
9.0IL1B, IL6, IL8
358.9MMP9, IL6, IL1B
368.9MMP9, IL8, IL6
378.9MMP9, IL8, IL6
388.9IL6, IL8, MMP9
398.9IL6, IL8, MMP9
40
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5MMP9, IL8, IL6, IL1B
418.5IL1B, IL6, IL8, MMP9

Compounds for genes affiliated with Recurrent Corneal Erosion

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide469.9IL1B, IL8
2muramyl tripeptide phosphatidylethanolamine469.7IL1B, IL6
3emedastine46 1210.7IL6, IL8
4turpentine469.6IL1B, IL6
5tepoxalin469.6IL8, IL6
6survanta469.5IL8, IL1B
7fluticasone propionate46 52 62 1212.5MMP9, IL8, IL1B
8ns 39846 6210.5MMP9, IL1B, IL8
9taurine chloramine469.4IL1B, IL6, IL8
10hbd2469.4IL6, IL8, IL1B
11mip 1alpha469.4IL1B, IL6, IL8
12il-12469.4IL8, IL1B, IL6
13tpck469.4IL6, IL8, IL1B
14sivelestat469.4IL6, IL8
15polymyxin b469.4IL6, IL1B, IL8
16groalpha469.4IL6, IL8, IL1B
17anaphylatoxin469.4IL8, IL6, IL1B
18triptolide469.4IL8, IL1B, IL6
19gm-csf46 3010.4IL1B, IL6, IL8
20lipoteichoic acid469.4IL8, IL6, IL1B
21helenalin469.4MMP9, IL6, IL1B
22polyinosinic-polycytidylic acid469.3IL8, IL1B, IL6
23etanercept46 52 1211.3IL1B, IL8, IL6
24poly(i-c)469.3IL8, IL6, IL1B
25gabexate mesilate469.3IL6, IL8, MMP9
26il 10469.3IL1B, IL6, IL8
27peptidoglycan46 3010.3IL6, IL1B, IL8
28parthenolide46 310.3IL6, IL8, MMP9
298-isoprostane469.2IL6, MMP9, IL8
30pentoxifylline46 1210.2IL8, IL6, IL1B
31ivig469.2IL1B, MMP9, IL6
32neopterin469.1IL1B, IL6, IL8
3315-deoxy-delta-12,14-prostaglandin j2469.1IL6, IL8, IL1B
34ciglitazone46 309.9MMP9, IL1B, IL6, IL8
35ccl346 309.9IL1B, MMP9, IL8, IL6
36pdtc468.9IL8, IL6, MMP9, IL1B
37leukotriene b446 62 2510.9IL6, IL1B, MMP9, IL8
38sp 60012546 629.9IL1B, IL6, IL8, MMP9
39troglitazone46 30 62 1211.9IL1B, IL8, IL6, MMP9
40herbimycin a46 629.9IL1B, IL6, MMP9, IL8
41hyaluronic acid46 259.9MMP9, IL1B, IL8, IL6
42curcumin468.9IL8, IL1B, IL6, MMP9
43aprotinin46 129.9IL8, IL6, MMP9
44rantes468.8IL6, IL1B, IL8, MMP9
45n acetylcysteine468.8MMP9, IL6, IL1B, IL8
46sb 20358046 629.8IL6, IL1B, IL8, MMP9
47pd 98,059468.7IL1B, MMP9, IL8, IL6
48ly294002468.7IL1B, IL6, IL8, MMP9
49actinomycin d468.5MMP9, IL1B, IL6, IL8
50genistein46 30 62 3 25 1213.2IL1B, MMP9, IL8, IL6

GO Terms for genes affiliated with Recurrent Corneal Erosion

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17Gene Ontology
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Cellular components related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TGFBI, MMP9, IL8, IL6, IL1B
2extracellular spaceGO:0056157.8TGFBI, MMP9, IL8, IL6, IL1B

Biological processes related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.7IL1B, MMP9
2neutrophil chemotaxisGO:0305939.6IL8, IL1B
3positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, IL6
4positive regulation of interleukin-6 productionGO:0327559.3IL1B, IL6
5positive regulation of T cell proliferationGO:0421029.1IL1B, IL6
6inflammatory responseGO:0069549.1IL1B, IL6, IL8
7negative regulation of cell proliferationGO:0082859.0IL1B, IL6, IL8

Products for genes affiliated with Recurrent Corneal Erosion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Recurrent Corneal Erosion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet