MCID: RCR001
MIFTS: 35

Recurrent Corneal Erosion

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 14
Recurrent Erosion of Cornea 12 69
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD10 33 H18.83
ICD9CM 35 371.42
UMLS 69 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to epithelial recurrent erosion dystrophy and corneal dystrophy, avellino type. An important gene associated with Recurrent Corneal Erosion is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Ophthalmic Solutions and Tetrahydrozoline have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 72 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
id Related Disease Score Top Affiliating Genes
1 epithelial recurrent erosion dystrophy 11.2
2 corneal dystrophy, avellino type 10.9
3 corneal dystrophy, lattice type iiia 10.9
4 lacrimal apparatus disease 10.4 CXCL8 IL1B
5 chancroid 10.4 CXCL8 IL1B
6 amyotrophic lateral sclerosis type 10 10.4 CXCL8 IL1B
7 epulis 10.4 CXCL8 IL1B
8 senile reticular retinal degeneration 10.4 CXCL8 IL1B
9 hidradenitis 10.4 CXCL8 IL1B
10 whistling face syndrome, recessive form 10.4 CXCL8 IL1B
11 testicular infarct 10.4 CXCL8 IL1B
12 tibialis tendinitis 10.3 CXCL8 IL1B
13 fibrosarcomatous osteosarcoma 10.3 CXCL8 IL1B
14 extrahepatic bile duct papillary adenoma 10.3 CXCL8 IL1B
15 drug rash with eosinophilia and systemic symptoms 10.3 CXCL8 IL6
16 spirillary rat-bite fever 10.3 CXCL8 IL6
17 sinusitis 10.3 CXCL8 IL1B
18 schwannoma of ureter 10.3 CXCL8 IL6
19 psychotic disorder 10.3 CXCL8 IL6
20 acute myeloblastic leukemia without maturation 10.3 CXCL8 IL6
21 labyrinthine bilateral reactive loss 10.3 CXCL8 IL6
22 pasteurellosis 10.3 CXCL8 IL6
23 pyelonephritis 10.3 CXCL8 IL1B
24 osteogenesis imperfecta, type x 10.3 CXCL8 IL6
25 cicatricial lagophthalmos 10.3 CXCL8 IL6
26 plantar fascial fibromatosis 10.3 CXCL8 IL1B
27 autosomal dominant polycystic kidney disease 10.3 CXCL8 IL6
28 orthostatic proteinuria 10.3 CXCL8 IL6
29 tricho onychic dysplasia 10.3 CXCL8 IL6
30 churg-strauss syndrome 10.3 CXCL8 IL1B
31 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 10.3 CXCL8 IL1B
32 myofascial pain syndrome 10.3 CXCL8 IL6
33 lateral cystocele 10.3 CXCL8 IL6
34 retinal vascular occlusion 10.3 CXCL8 IL1B
35 allergic bronchopulmonary aspergillosis 10.3 CXCL8 IL6
36 sheehan syndrome 10.3 CXCL8 IL1B
37 dysphagia 10.3 CXCL8 IL6
38 benign eccrine breast spiradenoma 10.3 CXCL8 IL1B
39 breast papillary carcinoma 10.3 CXCL8 IL6
40 esophagus leiomyoma 10.3 CXCL8 IL6
41 pneumoconiosis 10.3 CXCL8 IL6
42 bardet-biedl syndrome 8 10.2 CXCL8 IL6
43 scrotal carcinoma 10.2 IL1B IL6
44 x-linked dominant intellectual disability-epilepsy syndrome 10.2 IL1B IL6
45 spontaneous ocular nystagmus 10.2 CXCL8 IL1B
46 congenital nonspherocytic hemolytic anemia 10.2 IL1B IL6
47 upper gum cancer 10.2 IL1B IL6
48 bipolar i disorder 10.2 IL1B IL6
49 uterine corpus dissecting leiomyoma 10.2 CXCL8 IL6
50 alcohol abuse 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4
2 Tetrahydrozoline Phase 4
3
Ephedrine Approved 299-42-3 9294
4
Pseudoephedrine Approved 90-82-4 7028
5 Autonomic Agents
6 Lubricant Eye Drops
7 Nasal Decongestants
8 Peripheral Nervous System Agents
9 Pharmaceutical Solutions
10 Respiratory System Agents
11 Vasoconstrictor Agents
12 Dextrans

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phototherapeutic Keratectomy (PTK) on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Umbilical Cord Serum Eye Drops Completed NCT01016158 Umbilical cord serum eyedrops
5 Study of Dehydrex in Patients With Corneal Erosion Completed NCT00029185 Dehydrex
6 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

39
Eye

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 79)
id Title Authors Year
1
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. ( 26932827 )
2016
2
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. ( 26786512 )
2016
3
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. ( 25900814 )
2015
4
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. ( 26203746 )
2015
5
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. ( 26203756 )
2015
6
Optical coherence tomography findings in recurrent corneal erosion syndrome. ( 25532997 )
2015
7
Microbiological Study of Therapeutic Soft Contact Lenses Used in the Treatment of Recurrent Corneal Erosion Syndrome. ( 25230080 )
2014
8
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 23759442 )
2014
9
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. ( 24439438 )
2014
10
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. ( 24699561 )
2014
11
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352599 )
2014
12
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352600 )
2014
13
Interventions for recurrent corneal erosion: a Cochrane Systematic review. ( 23989116 )
2013
14
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. ( 23974885 )
2013
15
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. ( 23821953 )
2013
16
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. ( 23989120 )
2013
17
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. ( 23230823 )
2013
18
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
19
Franceschetti hereditary recurrent corneal erosion. ( 22402249 )
2012
20
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. ( 22180150 )
2012
21
Recurrent Corneal Erosion Syndrome. ( 26107728 )
2012
22
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. ( 20847650 )
2011
23
Recurrent corneal erosions and epithelial basement membrane dystrophy. ( 20724847 )
2010
24
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. ( 20337327 )
2010
25
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. ( 20606026 )
2010
26
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. ( 19816187 )
2009
27
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. ( 19648776 )
2009
28
Recurrent corneal erosion syndrome. ( 19026329 )
2008
29
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. ( 19093010 )
2008
30
Recurrent corneal erosion syndrome. ( 18191654 )
2008
31
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. ( 18290949 )
2008
32
Recurrent corneal erosion: characteristics and management options. ( 18306941 )
2007
33
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. ( 17301117 )
2007
34
Small spot phototherapeutic keratectomy for recurrent corneal erosion. ( 17912944 )
2007
35
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. ( 18043199 )
2007
36
Recurrent corneal erosion. ( 17908600 )
2007
37
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. ( 17926110 )
2007
38
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. ( 17172888 )
2006
39
The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. ( 16604052 )
2006
40
Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. ( 16219742 )
2005
41
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). ( 16361033 )
2005
42
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15721675 )
2005
43
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. ( 15183802 )
2004
44
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. ( 14765101 )
2004
45
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15030848 )
2004
46
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. ( 12613981 )
2002
47
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. ( 11864879 )
2002
48
Recurrent corneal erosion after laser in situ keratomileusis. ( 11248819 )
2001
49
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. ( 11438047 )
2001
50
Phototherapeutic keratectomy for treatment of recurrent corneal erosion. ( 10609204 )
1999

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 CXCL8 IL1B IL6
2
Show member pathways
12.59 CXCL8 IL1B IL6
3
Show member pathways
12.54 CXCL8 IL1B IL6
4
Show member pathways
12.48 CXCL8 IL1B IL6
5
Show member pathways
12.11 CXCL8 IL1B IL6
6
Show member pathways
12.05 CXCL8 IL1B IL6
7
Show member pathways
11.96 CXCL8 IL1B IL6
8 11.95 CXCL8 IL1B IL6
9
Show member pathways
11.92 CXCL8 IL1B IL6
10 11.78 CXCL8 IL1B IL6
11 11.74 CXCL8 IL1B IL6
12 11.7 CXCL8 IL1B IL6
13
Show member pathways
11.69 IL1B IL6
14 11.67 CXCL8 IL1B
15
Show member pathways
11.65 CXCL8 IL6
16 11.65 CXCL8 IL1B IL6
17 11.62 CXCL8 IL1B IL6
18 11.59 CXCL8 IL6
19 11.56 CXCL8 IL1B IL6
20 11.55 IL1B IL6
21 11.51 CXCL8 IL1B IL6
22 11.48 CXCL8 IL6
23 11.43 CXCL8 IL1B IL6
24 11.4 CXCL8 IL6
25 11.36 CXCL8 IL6
26 11.33 IL1B IL6
27 11.3 IL1B IL6
28 11.3 CXCL8 IL1B IL6
29
Show member pathways
11.23 CXCL8 IL1B IL6
30 11.18 IL1B IL6
31 11.18 IL1B IL6
32 11.17 IL1B IL6
33 11.15 CXCL8 IL6
34 11.12 IL1B IL6
35 11.1 IL1B IL6
36 11.08 IL1B IL6
37 11.07 CXCL8 IL1B IL6
38 10.99 CXCL8 IL1B IL6
39 10.87 CXCL8 IL6
40 10.82 CXCL8 IL1B IL6
41 10.72 IL1B IL6
42 10.49 CXCL8 IL1B IL6

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DNAJC9 IL1B IL6 TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 CXCL8 IL1B IL6
2 cellular response to interleukin-1 GO:0071347 9.43 CXCL8 IL6
3 negative regulation of cell proliferation GO:0008285 9.43 CXCL8 IL1B IL6
4 neutrophil chemotaxis GO:0030593 9.37 CXCL8 IL1B
5 inflammatory response GO:0006954 9.33 CXCL8 IL1B IL6
6 positive regulation of T cell proliferation GO:0042102 9.32 IL1B IL6
7 positive regulation of interleukin-6 production GO:0032755 8.96 IL1B IL6
8 positive regulation of nitric oxide biosynthetic process GO:0045429 8.62 IL1B IL6

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL6

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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