MCID: RCR001
MIFTS: 43

Recurrent Corneal Erosion malady

Summaries for Recurrent Corneal Erosion

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

MalaCards: Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to adenocarcinoma and acute pancreatitis. An important gene associated with Recurrent Corneal Erosion is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Senescence and Autophagy and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds aprotinin and bis(2-chloroethyl)sulfide have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

Aliases & Classifications for Recurrent Corneal Erosion

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

recurrent corneal erosion 8 10
recurrent erosion of cornea 8 61
recurrent erosion syndrome 8
recurrence 61


External Ids:

Disease Ontology8 DOID:11541
ICD9CM27 371.42

Related Diseases for Recurrent Corneal Erosion

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2562)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.9TACSTD2, MMP9, TGFBI
2acute pancreatitis30.9IL6, IL8
3colorectal cancer30.8TGFBI, MMP9
4astrocytoma30.6MMP9, IL6, IL1B
5bacterial vaginosis30.4IL1B, IL8
6lattice corneal dystrophy30.4TGFBI, TACSTD2
7arthritis30.4MMP9, IL6, IL1B, IL8
8oral cancer30.4MMP9
9duodenal ulcer30.3IL8
10cystic fibrosis30.3IL8
11synovitis30.3IL8, IL1B, IL6
12bacterial meningitis30.3IL8, IL1B
13familial mediterranean fever30.2IL1B
14thrombocytopenia30.1IL6
15acute myocardial infarction30.1MMP9
16bronchiolitis30.0IL8
17vascular disease30.0IL6, IL1B, IL8
18ulcerative colitis30.0IL6, IL1B, IL8
19chorioamnionitis29.9IL8, IL1B, IL6
20sepsis29.9IL8, IL1B, IL6
21atherosclerosis29.9IL8, IL1B, IL6, MMP9
22kawasaki disease29.9MMP9
23coronary heart disease29.9IL6
24corneal disease29.9TGFBI, KRT12
25primary hyperoxaluria29.9IL6, IL1B
26brain edema29.7MMP9
27allergic rhinitis29.7IL8
28toxic shock syndrome29.7IL1B
29osteoarthritis29.7MMP9, IL6, IL1B, IL8
30bronchiolitis obliterans29.6IL8
31bronchiectasis29.6IL8
32kaposi's sarcoma29.6IL6
33common cold29.6IL8
34arthropathy29.6IL1B
35vernal keratoconjunctivitis29.6MMP9, IL8
36poems syndrome29.6IL6, IL1B
37septic shock29.6IL8, IL1B, IL6
38abdominal aortic aneurysm29.5MMP9
39bronchopulmonary dysplasia29.5IL8
40proliferative diabetic retinopathy29.5MMP9, IL8
41insulin resistance29.5IL6
42muckle-wells syndrome29.3IL1B
43viral meningitis29.3IL8, IL6
44amyloid tumor29.3TGFBI, KRT12
45pulmonary disease, chronic obstructive29.3MMP9, IL6, IL8
46idiopathic pulmonary fibrosis29.2MMP9, IL1B, IL8
47stomatitis10.8
48aphthous stomatitis10.8
49recurrent respiratory papillomatosis10.8
50squamous cell carcinoma10.7

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to recurrent corneal erosion

Clinical Features for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Recurrent Corneal Erosion

Drug clinical trials:

Search ClinicalTrials for Recurrent Corneal Erosion

Search NIH Clinical Center for Recurrent Corneal Erosion

Search CenterWatch for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

Animal Models for Recurrent Corneal Erosion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Recurrent Corneal Erosion:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5TGFBI, MMP9, TACSTD2, IL6, IL1B

Publications for Recurrent Corneal Erosion

Sources:
51PubMed
See all sources

Articles related to Recurrent Corneal Erosion:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352600)
2014
2
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (23759442)
2014
3
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352599)
2014
4
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. (23230823)
2013
5
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. (23989120)
2013
6
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (23821953)
2013
7
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. (22180150)
2012
8
Franceschetti hereditary recurrent corneal erosion. (22402249)
2012
9
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. (20847650)
2011
10
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. (20337327)
2010
11
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. (20606026)
2010
12
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. (19648776)
2009
13
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. (18290949)
2008
14
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. (19093010)
2008
15
Recurrent corneal erosion syndrome. (18191654)
2008
16
Small spot phototherapeutic keratectomy for recurrent corneal erosion. (17912944)
2007
17
Sterile corneal ulcer with ring infiltrate and hypopyon after recurrent erosions. (16980934)
2007
18
Recurrent corneal erosion: characteristics and management options. (18306941)
2007
19
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. (18043199)
2007
20
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. (17926110)
2007
21
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. (17172888)
2006
22
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). (16361033)
2005
23
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15721675)
2005
24
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. (15183802)
2004
25
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15030848)
2004
26
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. (11864879)
2002
27
Recurrent corneal erosion after laser in situ keratomileusis. (11248819)
2001
28
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. (10235563)
1999
29
Recurrent corneal erosion syndrome. (10535864)
1999
30
Excimer laser phototherapeutic keratectomy for recurrent corneal erosion. (9584237)
1998
31
Combined PRK and PTK in myopic patients with recurrent corneal erosion. (9290367)
1997
32
Recurrent corneal erosion associated with Alport's syndrome. Rapid communication. (9211364)
1997
33
Phototherapeutic keratectomy in macular corneal dystrophy with recurrent erosions. (8653514)
1996
34
The natural history and management of recurrent corneal erosion: a prospective randomised trial. (8013716)
1994
35
Recurrent corneal erosion: clinical features. (7821454)
1994
36
Simplified microsurgical method of therapy for recurrent corneal erosion. (1483124)
1992
37
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (2220975)
1990
38
Recurrent corneal erosion. (2803088)
1989
39
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex KAPbner and X-linked ichthyosis with steroid sulfatase deficiency. (3165358)
1988
40
Non-traumatic recurrent corneal erosion. A study based on sequential photomacrographic recordings. (3501223)
1987
41
The treatment of recurrent corneal erosion. (3820505)
1987
42
Recurrent corneal erosion, microcystic epithelial dystrophy, map configurations and fingerprint lines in the cornea. (3490898)
1986
43
Pathogenesis of recurrent corneal erosion: a further aetiological factor? (3491447)
1986
44
Recurrent corneal erosion after trauma: a statistical study. (4062156)
1985
45
Using a bandage contact lens to prevent recurrent corneal erosion during photocoagulation in patients with diabetes. (7197882)
1981
46
Treatment of recurrent corneal erosion and corneal edema with topical osmotic colloidal solution. (6172765)
1981
47
Recurrent corneal erosion: pathogenesis and therapy. (110716)
1979
48
Recurrent corneal erosion. (4544649)
1973
49
Ultrastructural study of non-traumatic recurrent corneal erosion. (4110772)
1972
50
Traumatic recurrent corneal erosion or aseptic corneal inflammation. (4098215)
1970

Genetic Variations for Recurrent Corneal Erosion

Expression for genes affiliated with Recurrent Corneal Erosion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for genes affiliated with Recurrent Corneal Erosion

Sources:
38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 30KEGG, 54Reactome
See all sources

Pathways related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL8
210.0IL1B
39.5IL8, IL6
49.5IL6, IL1B
59.5IL1B, IL6
69.5IL6, IL1B
79.2IL8, IL6, MMP9
89.2MMP9, IL6, IL8
99.2MMP9, IL6, IL8
109.1MMP9, IL6, IL1B
119.1MMP9, IL6, IL1B
129.1IL8, IL1B, IL6
139.1IL6, IL1B, IL8
14
Immune response Bacterial infections in normal airways
Hide members
9.1IL8, IL1B, IL6
159.1IL6, IL1B, IL8
169.1IL6, IL1B, IL8
17
Hide members
9.1IL8, IL1B, IL6
18
Hide members
9.1IL6, IL1B, IL8
199.1IL8, IL1B, IL6
20
Hide members
9.1IL8, IL1B, IL6
219.1IL6, IL1B, IL8
229.1IL6, IL1B, IL8
23
Hide members
8.7MMP9, IL6, IL1B, IL8

Compounds for genes affiliated with Recurrent Corneal Erosion

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 24HMDB
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Compounds related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1aprotinin45 1111.1IL8
2bis(2-chloroethyl)sulfide4510.0IL8, IL1B
3emedastine45 1110.9IL6, IL8
4tepoxalin459.9IL8, IL6
5muramyl tripeptide phosphatidylethanolamine459.9IL1B, IL6
6survanta459.9IL8, IL1B
7turpentine459.8IL1B, IL6
8sivelestat459.8IL8, IL6
9echinacea459.8IL1B, IL8
10rebamipide459.7IL8, IL6
11fluticasone propionate45 50 60 1112.6IL1B, IL8, MMP9
12gabexate mesilate459.6IL8, IL6, MMP9
13ns 39845 6010.6MMP9, IL8, IL1B
14parthenolide45 210.6IL8, MMP9, IL6
15helenalin459.6IL6, MMP9, IL1B
168-isoprostane459.5IL8, MMP9, IL6
17taurine chloramine459.5IL6, IL1B, IL8
18hbd2459.5IL6, IL8, IL1B
19mip 1alpha459.5IL6, IL1B, IL8
20il-12459.5IL8, IL1B, IL6
21tpck459.5IL8, IL6, IL1B
22polymyxin b459.5IL8, IL1B, IL6
23groalpha459.5IL6, IL8, IL1B
24anaphylatoxin459.5IL6, IL1B, IL8
25triptolide459.5IL8, IL1B, IL6
26lipoteichoic acid459.5IL6, IL1B, IL8
27polyinosinic-polycytidylic acid459.5IL1B, IL8, IL6
28etanercept45 50 1111.5IL6, IL1B, IL8
29poly(i-c)459.4IL8, IL1B, IL6
30il 10459.4IL1B, IL6, IL8
31peptidoglycan45 2910.4IL8, IL6, IL1B
32neopterin459.3IL8, IL6, IL1B
3315-deoxy-delta-12,14-prostaglandin j2459.3IL8, IL6, IL1B
34bucillamine459.2IL1B, IL6
35ciglitazone45 2910.2IL8, IL1B, IL6, MMP9
36ccl345 2910.2IL6, MMP9, IL8, IL1B
37pdtc459.2IL6, IL8, IL1B, MMP9
38leukotriene b445 60 2411.1IL6, IL8, IL1B, MMP9
39sp 60012545 6010.1IL8, IL1B, MMP9, IL6
40troglitazone45 29 60 1112.1IL8, IL6, IL1B, MMP9
41herbimycin a45 6010.1IL6, IL1B, IL8, MMP9
42hyaluronic acid45 2410.1IL8, IL6, IL1B, MMP9
43curcumin459.1IL6, IL1B, MMP9, IL8
44rantes459.0IL6, IL1B, IL8, MMP9
45n acetylcysteine459.0IL8, IL6, IL1B, MMP9
46sb 20358045 6010.0MMP9, IL1B, IL8, IL6
47pd 98,059458.8IL8, IL1B, IL6, MMP9
48ly294002458.8IL6, IL1B, IL8, MMP9
49genistein45 29 60 2 11 2413.7MMP9, IL6, IL1B, IL8
50actinomycin d458.6IL8, IL1B, IL6, MMP9

GO Terms for genes affiliated with Recurrent Corneal Erosion

Sources:
16Gene Ontology
See all sources

Cellular components related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1TGFBI, MMP9, TACSTD2, IL6, IL1B, IL8

Biological processes related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.6MMP9, IL1B
2visual perceptionGO:0076019.4TGFBI, KRT12, TACSTD2
3positive regulation of nitric oxide biosynthetic processGO:0454299.2IL6, IL1B

Products for genes affiliated with Recurrent Corneal Erosion

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Recurrent Corneal Erosion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet