MCID: RCR001
MIFTS: 44

Recurrent Corneal Erosion malady

Summaries for Recurrent Corneal Erosion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

MalaCards: Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to prostate cancer and hepatocellular carcinoma. An important gene associated with Recurrent Corneal Erosion is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Senescence and Autophagy and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds aprotinin and bis(2-chloroethyl)sulfide have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Recurrent Corneal Erosion

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

recurrent corneal erosion 8 10
recurrent erosion of cornea 8 60
recurrent erosion syndrome 8
recurrence 60


External Ids:

Disease Ontology8 DOID:11541
ICD9CM27 371.42

Related Diseases for Recurrent Corneal Erosion

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17GeneCards, 18GeneDecks
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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2396)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer31.0IL6, MMP9
2hepatocellular carcinoma31.0MMP9, IL6
3adenocarcinoma30.9TACSTD2, MMP9, TGFBI
4acute pancreatitis30.9IL6, IL8
5meningitis30.8MMP9, IL6, IL1B, IL8
6ovarian cancer30.8MMP9
7colorectal cancer30.8TGFBI, MMP9
8corneal dystrophy30.7TACSTD2, KRT12, TGFBI
9malignant glioma30.7MMP9
10melanoma30.7IL8, MMP9
11peritonitis30.7IL1B, IL6
12keratitis30.7MMP9
13otitis media30.6IL1B
14glomerulonephritis30.6IL1B
15astrocytoma30.6MMP9, IL6, IL1B
16colon cancer30.5MMP9
17bacterial vaginosis30.4IL1B, IL8
18lattice corneal dystrophy30.4TGFBI, TACSTD2
19arthritis30.4MMP9, IL6, IL1B, IL8
20peptic ulcer30.4IL8
21glioblastoma multiforme30.3IL8, MMP9
22duodenal ulcer30.3IL8
23cystic fibrosis30.3IL8
24synovitis30.3IL8, IL1B, IL6
25bacterial meningitis30.3IL8, IL1B
26osteosarcoma30.2MMP9
27sarcoidosis30.2IL1B
28cholesteatoma30.2MMP9
29endometriosis30.2IL8, IL1B, IL6
30pancreatic cancer30.2MMP9, TACSTD2, IL8
31familial mediterranean fever30.2IL1B
32diabetes mellitus30.1MMP9, IL6, IL1B
33thrombocytopenia30.1IL6
34acute myocardial infarction30.0MMP9
35rheumatoid arthritis30.0RNGTT, IL8, IL1B, IL6, MMP9
36bronchiolitis30.0IL8
37vascular disease30.0IL6, IL1B, IL8
38ulcerative colitis30.0IL6, IL1B, IL8
39keratopathy30.0FAM46D
40chorioamnionitis29.9IL8, IL1B, IL6
41atherosclerosis29.9IL8, IL1B, IL6, MMP9
42corneal disease29.9TGFBI, KRT12
43primary hyperoxaluria29.9IL6, IL1B
44respiratory failure29.9IL6, IL1B
45mastitis29.9IL1B, IL8
46pulmonary fibrosis29.9IL8, IL1B, MMP9
47kawasaki disease29.8MMP9
48rhinitis29.8IL8
49gingivitis29.8IL1B
50keratoconus29.8KRT12, TGFBI

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to recurrent corneal erosion

Clinical Features for Recurrent Corneal Erosion

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Drugs & Therapeutics for Recurrent Corneal Erosion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Recurrent Corneal Erosion

Drug clinical trials:

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Search NIH Clinical Center for Recurrent Corneal Erosion

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Genetic Tests for Recurrent Corneal Erosion

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Anatomical Context for Recurrent Corneal Erosion

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32MalaCards
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MalaCards organs/tissues related to Recurrent Corneal Erosion:

32
Eye

Animal Models for Recurrent Corneal Erosion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Recurrent Corneal Erosion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5TGFBI, MMP9, TACSTD2, IL6, IL1B

Publications for Recurrent Corneal Erosion

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50PubMed
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Articles related to Recurrent Corneal Erosion:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352599)
2014
2
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. (23230823)
2013
3
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. (23989120)
2013
4
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. (23132456)
2013
5
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (23821953)
2013
6
Franceschetti hereditary recurrent corneal erosion. (22402249)
2012
7
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. (20847650)
2011
8
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. (20337327)
2010
9
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. (20606026)
2010
10
Dystrophia Helsinglandica--corneal morphology, topography and sensitivity in a hereditary corneal disease with recurrent erosive episodes. (20597871)
2010
11
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. (19648776)
2009
12
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. (19816187)
2009
13
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. (18290949)
2008
14
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. (19093010)
2008
15
A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance. (18778339)
2008
16
Recurrent corneal erosion syndrome. (18191654)
2008
17
Recurrent corneal erosion. (17908600)
2007
18
Small spot phototherapeutic keratectomy for recurrent corneal erosion. (17912944)
2007
19
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. (17301117)
2007
20
Recurrent corneal erosion: characteristics and management options. (18306941)
2007
21
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. (18043199)
2007
22
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. (17926110)
2007
23
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. (17172888)
2006
24
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15030848)
2004
25
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. (11864879)
2002
26
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. (10235563)
1999
27
Recurrent corneal erosion syndrome. (10535864)
1999
28
Excimer laser phototherapeutic keratectomy for recurrent corneal erosion. (9584237)
1998
29
Recurrent corneal erosion associated with Alport's syndrome. Rapid communication. (9211364)
1997
30
Phototherapeutic keratectomy in macular corneal dystrophy with recurrent erosions. (8653514)
1996
31
Excimer laser phototherapeutic keratectomy for treatment of recurrent corneal erosion. (8201570)
1994
32
Recurrent corneal erosion in cystinosis. (7807309)
1994
33
Simplified microsurgical method of therapy for recurrent corneal erosion. (1483124)
1992
34
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (1992755)
1991
35
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (2220975)
1990
36
Recurrent corneal erosion. (2803088)
1989
37
Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex KAPbner and X-linked ichthyosis with steroid sulfatase deficiency. (3165358)
1988
38
Non-traumatic recurrent corneal erosion. A study based on sequential photomacrographic recordings. (3501223)
1987
39
The treatment of recurrent corneal erosion. (3820505)
1987
40
Recurrent corneal erosion, microcystic epithelial dystrophy, map configurations and fingerprint lines in the cornea. (3490898)
1986
41
Pathogenesis of recurrent corneal erosion: a further aetiological factor? (3491447)
1986
42
Recurrent corneal erosion after trauma: a statistical study. (4062156)
1985
43
Posttraumatic recurrent corneal erosion. 1. Clinical and histological studies. (7185021)
1982
44
Inherited recurrent corneal erosion. (6985236)
1981
45
Using a bandage contact lens to prevent recurrent corneal erosion during photocoagulation in patients with diabetes. (7197882)
1981
46
Treatment of recurrent corneal erosion and corneal edema with topical osmotic colloidal solution. (6172765)
1981
47
Recurrent corneal erosion: pathogenesis and therapy. (110716)
1979
48
Recurrent corneal erosion. (4544649)
1973
49
Ultrastructural study of non-traumatic recurrent corneal erosion. (4110772)
1972
50
Traumatic recurrent corneal erosion or aseptic corneal inflammation. (4098215)
1970

Genetic Variations for Recurrent Corneal Erosion

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Expression for genes affiliated with Recurrent Corneal Erosion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for genes affiliated with Recurrent Corneal Erosion

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37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 29KEGG, 53Reactome
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Pathways related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL8
210.0IL1B
39.5IL8, IL6
49.5IL6, IL1B
59.5IL1B, IL6
69.5IL6, IL1B
79.2IL8, IL6, MMP9
89.2MMP9, IL6, IL8
99.2MMP9, IL6, IL8
109.1MMP9, IL6, IL1B
119.1MMP9, IL6, IL1B
129.1IL8, IL1B, IL6
139.1IL6, IL1B, IL8
14
Immune response Bacterial infections in normal airways
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9.1IL8, IL1B, IL6
159.1IL6, IL1B, IL8
169.1IL6, IL1B, IL8
17
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9.1IL8, IL1B, IL6
18
Hide members
9.1IL6, IL1B, IL8
199.1IL8, IL1B, IL6
20
Hide members
9.1IL8, IL1B, IL6
219.1IL6, IL1B, IL8
229.1IL6, IL1B, IL8
23
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8.7MMP9, IL6, IL1B, IL8

Compounds for genes affiliated with Recurrent Corneal Erosion

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 24HMDB
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Compounds related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1aprotinin44 1111.1IL8
2bis(2-chloroethyl)sulfide4410.0IL8, IL1B
3emedastine44 1110.9IL6, IL8
4tepoxalin449.9IL8, IL6
5muramyl tripeptide phosphatidylethanolamine449.9IL1B, IL6
6survanta449.9IL8, IL1B
7turpentine449.8IL1B, IL6
8sivelestat449.8IL8, IL6
9echinacea449.8IL1B, IL8
10rebamipide449.7IL8, IL6
11fluticasone propionate44 49 59 1112.6IL1B, IL8, MMP9
12gabexate mesilate449.6IL8, IL6, MMP9
13ns 39844 5910.6MMP9, IL8, IL1B
14parthenolide44 210.6IL8, MMP9, IL6
15helenalin449.6IL6, MMP9, IL1B
168-isoprostane449.5IL8, MMP9, IL6
17taurine chloramine449.5IL6, IL1B, IL8
18hbd2449.5IL6, IL8, IL1B
19mip 1alpha449.5IL6, IL1B, IL8
20il-12449.5IL8, IL1B, IL6
21tpck449.5IL8, IL6, IL1B
22polymyxin b449.5IL8, IL1B, IL6
23groalpha449.5IL6, IL8, IL1B
24anaphylatoxin449.5IL6, IL1B, IL8
25triptolide449.5IL8, IL1B, IL6
26lipoteichoic acid449.5IL6, IL1B, IL8
27polyinosinic-polycytidylic acid449.5IL1B, IL8, IL6
28etanercept44 49 1111.5IL6, IL1B, IL8
29poly(i-c)449.4IL8, IL1B, IL6
30il 10449.4IL1B, IL6, IL8
31peptidoglycan44 2810.4IL8, IL6, IL1B
32neopterin449.3IL8, IL6, IL1B
3315-deoxy-delta-12,14-prostaglandin j2449.3IL8, IL6, IL1B
34bucillamine449.2IL1B, IL6
35ciglitazone44 2810.2IL8, IL1B, IL6, MMP9
36ccl344 2810.2IL6, MMP9, IL8, IL1B
37pdtc449.2IL6, IL8, IL1B, MMP9
38leukotriene b444 59 2411.1IL6, IL8, IL1B, MMP9
39sp 60012544 5910.1IL8, IL1B, MMP9, IL6
40troglitazone44 28 59 1112.1IL8, IL6, IL1B, MMP9
41herbimycin a44 5910.1IL6, IL1B, IL8, MMP9
42hyaluronic acid44 2410.1IL8, IL6, IL1B, MMP9
43curcumin449.1IL6, IL1B, MMP9, IL8
44rantes449.0IL6, IL1B, IL8, MMP9
45n acetylcysteine449.0IL8, IL6, IL1B, MMP9
46sb 20358044 5910.0MMP9, IL1B, IL8, IL6
47pd 98,059448.8IL8, IL1B, IL6, MMP9
48ly294002448.8IL6, IL1B, IL8, MMP9
49genistein44 28 59 2 11 2413.7MMP9, IL6, IL1B, IL8
50actinomycin d448.6IL8, IL1B, IL6, MMP9

GO Terms for genes affiliated with Recurrent Corneal Erosion

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16Gene Ontology
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Cellular components related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1TGFBI, MMP9, TACSTD2, IL6, IL1B, IL8

Biological processes related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.6MMP9, IL1B
2visual perceptionGO:0076019.4TGFBI, KRT12, TACSTD2
3positive regulation of nitric oxide biosynthetic processGO:0454299.2IL6, IL1B

Products for genes affiliated with Recurrent Corneal Erosion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Recurrent Corneal Erosion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet