MCID: RCR001
MIFTS: 44

Recurrent Corneal Erosion malady

Eye diseases category
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Summaries for Recurrent Corneal Erosion

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Wikipedia:65 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

MalaCards based summary: Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to corneal dystrophy and muckle-wells syndrome. An important gene associated with Recurrent Corneal Erosion is KRT12 (keratin 12), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cell adhesion ECM remodeling. The compounds bis(2-chloroethyl)sulfide and muramyl tripeptide phosphatidylethanolamine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Recurrent Corneal Erosion

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Recurrent Corneal Erosion, Aliases & Descriptions:

Name: Recurrent Corneal Erosion 8 10
Recurrent Erosion of Cornea 8 62
 
Recurrent Erosion Syndrome 8
Recurrence 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:11541
ICD9CM27 371.42

Related Diseases for Recurrent Corneal Erosion

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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy31.1KRT12, TGFBI
2muckle-wells syndrome10.4IL1B
3degenerative disc disease10.4IL1B
4periodontal disease10.4IL6
5conjunctivochalasis10.3MMP9
6corneal disease10.3TGFBI, KRT12
7amyloid tumor10.3KRT12, TGFBI
8abdominal aortic aneurysm10.3MMP9
9keratoconus10.2KRT12, TGFBI
10euthyroid sick syndrome10.2IL6, IL1B
11poems syndrome10.2IL6, IL1B
12cystinosis10.2
13lattice corneal dystrophy10.2
14astigmatism10.2
15corneal deposit10.2
16corneal edema10.2
17spiradenoma10.2IL1B, IL6
18viral meningitis10.2IL6, IL8
19respiratory failure10.1IL6, IL1B
20bacterial vaginosis10.1IL1B, IL8
21bacterial meningitis10.1IL1B, IL8
22mastitis10.1IL8, IL1B
23thrombocytosis10.1IL6, IL1B
24acquired immunodeficiency syndrome10.1IL1B, IL6
25peritonitis10.1IL1B, IL6
26prion disease10.0IL6, IL1B
27interstitial lung disease10.0IL1B, MMP9
28acute pancreatitis10.0IL8, IL6
29hypersensitivity reaction type ii disease10.0IL1B, IL6
30vernal keratoconjunctivitis10.0IL8, MMP9
31synovitis9.9IL8, IL6, IL1B
32chorioamnionitis9.9IL1B, IL6, IL8
33proliferative diabetic retinopathy9.9MMP9, IL8
34adult respiratory distress syndrome9.9IL8, IL6, IL1B
35monocytic leukemia9.9IL1B, IL6, IL8
36septic shock9.9IL1B, IL6, IL8
37colitis9.9IL1B, IL6, IL8
38endometriosis9.9IL8, IL6, IL1B
39gastritis9.9IL1B, IL8
40pneumonia9.9IL8, IL6, IL1B
41vascular disease9.9IL1B, IL6, IL8
42ulcerative colitis9.9IL8, IL6, IL1B
43sepsis9.9IL1B, IL6, IL8
44inflammatory bowel disease9.9IL8, IL6, IL1B
45psoriasis9.9IL1B, IL6, IL8
46skin disease9.9IL1B, IL6, MMP9
47congenital heart disease9.8IL1B, IL6, MMP9
48periodontitis9.8IL1B, IL8, MMP9
49viral infectious disease9.8IL1B, IL6, IL8
50idiopathic pulmonary fibrosis9.8IL1B, IL8, MMP9

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to recurrent corneal erosion

Symptoms for Recurrent Corneal Erosion

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Drugs & Therapeutics for Recurrent Corneal Erosion

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Drug clinical trials:

Search ClinicalTrials for Recurrent Corneal Erosion

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

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Anatomical Context for Recurrent Corneal Erosion

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MalaCards organs/tissues related to Recurrent Corneal Erosion:

32
Eye

Animal Models for Recurrent Corneal Erosion or affiliated genes

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MGI Mouse Phenotypes related to Recurrent Corneal Erosion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL1B, IL6, MMP9, TGFBI
2MP:00053878.1IL1B, IL6, IL8, MMP9, TGFBI
3MP:00053977.8TGFBI, MMP9, IL8, IL6, IL1B

Publications for Recurrent Corneal Erosion

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Articles related to Recurrent Corneal Erosion:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352600)
2014
2
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (23759442)
2014
3
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. (24699561)
2014
4
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. (24352599)
2014
5
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. (23230823)
2013
6
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. (23989120)
2013
7
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. (23132456)
2013
8
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (23821953)
2013
9
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. (22180150)
2012
10
Franceschetti hereditary recurrent corneal erosion. (22402249)
2012
11
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. (20847650)
2011
12
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. (20337327)
2010
13
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. (19648776)
2009
14
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. (18290949)
2008
15
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. (19093010)
2008
16
Recurrent corneal erosion syndrome. (19026329)
2008
17
Recurrent corneal erosion syndrome. (18191654)
2008
18
Recurrent corneal erosion. (17908600)
2007
19
Small spot phototherapeutic keratectomy for recurrent corneal erosion. (17912944)
2007
20
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. (17301117)
2007
21
Recurrent corneal erosion: characteristics and management options. (18306941)
2007
22
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. (17172888)
2006
23
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. (14765101)
2004
24
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. (15183802)
2004
25
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. (15030848)
2004
26
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. (12613981)
2002
27
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. (11438047)
2001
28
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. (10235563)
1999
29
Recurrent corneal erosion syndrome. (10535864)
1999
30
Phototherapeutic keratectomy for treatment of recurrent corneal erosion. (10609204)
1999
31
Combined PRK and PTK in myopic patients with recurrent corneal erosion. (9290367)
1997
32
Corneal topographic lagoons: a potential new marker for post-traumatic recurrent corneal erosion syndrome. (8743001)
1996
33
The natural history and management of recurrent corneal erosion: a prospective randomised trial. (8013716)
1994
34
Excimer laser phototherapeutic keratectomy for treatment of recurrent corneal erosion. (8201570)
1994
35
Recurrent corneal erosion: clinical features. (7821454)
1994
36
Recurrent corneal erosion in cystinosis. (7807309)
1994
37
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (1992755)
1991
38
Recurrent corneal erosion: pathology of corneal puncture. (1935141)
1991
39
Successful treatment of recurrent corneal erosion with Nd:YAG anterior stromal puncture. (2220975)
1990
40
Recurrent corneal erosion. (2803088)
1989
41
Non-traumatic recurrent corneal erosion. A study based on sequential photomacrographic recordings. (3501223)
1987
42
The treatment of recurrent corneal erosion. (3820505)
1987
43
Recurrent corneal erosion, microcystic epithelial dystrophy, map configurations and fingerprint lines in the cornea. (3490898)
1986
44
Recurrent corneal erosion after trauma: a statistical study. (4062156)
1985
45
Posttraumatic recurrent corneal erosion, #2. Ultrastructural findings in epithelium and stroma. (6621361)
1983
46
Posttraumatic recurrent corneal erosion. 1. Clinical and histological studies. (7185021)
1982
47
Inherited recurrent corneal erosion. (6985236)
1981
48
Using a bandage contact lens to prevent recurrent corneal erosion during photocoagulation in patients with diabetes. (7197882)
1981
49
Treatment of recurrent corneal erosion and corneal edema with topical osmotic colloidal solution. (6172765)
1981
50
Recurrent corneal erosion. (4544649)
1973

Variations for Recurrent Corneal Erosion

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Expression for genes affiliated with Recurrent Corneal Erosion

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Expression patterns in normal tissues for genes affiliated with Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for genes affiliated with Recurrent Corneal Erosion

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Pathways related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, MMP9
2
Show member pathways
9.5IL8, MMP9
39.4IL1B, IL6
49.4IL1B, IL6
5
Show member pathways
9.4IL1B, IL6
69.4IL1B, IL6
7
Show member pathways
IL27-mediated signaling events37
9.4IL1B, IL6
89.4IL1B, IL6
9
Show member pathways
thioredoxin pathway37
9.4IL1B, IL6
109.4IL6, IL1B
119.4IL6, IL1B
129.4IL6, IL1B
139.4IL8, IL6
149.4IL6, IL8
159.4IL6, IL8
169.4IL8, IL6
17
Show member pathways
9.4IL8, IL6
189.3IL6, MMP9
19
Show member pathways
9.0IL1B, IL6, IL8
20
Show member pathways
9.0IL1B, IL6, IL8
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0IL1B, IL6, IL8
229.0IL8, IL6, IL1B
23
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0IL1B, IL6, IL8
249.0IL8, IL6, IL1B
259.0IL1B, IL6, IL8
269.0IL8, IL6, IL1B
279.0IL8, IL6, IL1B
289.0IL1B, IL6, IL8
29
Show member pathways
Immune response MIF in innate immunity response60
9.0IL1B, IL6, IL8
30
Show member pathways
9.0IL8, IL6, IL1B
319.0IL1B, IL6, IL8
329.0IL8, IL6, IL1B
339.0IL1B, IL6, IL8
34
Show member pathways
9.0IL1B, IL6, IL8
358.9MMP9, IL6, IL1B
368.9MMP9, IL8, IL6
378.9MMP9, IL8, IL6
388.9IL6, IL8, MMP9
398.9IL6, IL8, MMP9
40
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5MMP9, IL8, IL6, IL1B
418.5IL1B, IL6, IL8, MMP9

Compounds for genes affiliated with Recurrent Corneal Erosion

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Compounds related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1bis(2-chloroethyl)sulfide449.9IL8, IL1B
2muramyl tripeptide phosphatidylethanolamine449.7IL6, IL1B
3emedastine44 1110.7IL8, IL6
4turpentine449.6IL1B, IL6
5tepoxalin449.6IL6, IL8
6survanta449.5IL8, IL1B
7fluticasone propionate44 50 61 1112.5MMP9, IL8, IL1B
8ns 39844 6110.5MMP9, IL8, IL1B
9taurine chloramine449.4IL1B, IL6, IL8
10hbd2449.4IL1B, IL6, IL8
11mip 1alpha449.4IL8, IL6, IL1B
12il-12449.4IL8, IL6, IL1B
13tpck449.4IL8, IL6, IL1B
14sivelestat449.4IL8, IL6
15polymyxin b449.4IL1B, IL6, IL8
16groalpha449.4IL8, IL6, IL1B
17anaphylatoxin449.4IL1B, IL6, IL8
18gm-csf44 2810.4IL8, IL6, IL1B
19triptolide449.4IL8, IL6, IL1B
20lipoteichoic acid449.4IL8, IL6, IL1B
21helenalin449.4IL1B, IL6, MMP9
22polyinosinic-polycytidylic acid449.3IL8, IL6, IL1B
23etanercept44 50 1111.3IL1B, IL6, IL8
24poly(i-c)449.3IL1B, IL6, IL8
25gabexate mesilate449.3MMP9, IL8, IL6
26il 10449.3IL8, IL6, IL1B
27peptidoglycan44 2810.3IL1B, IL6, IL8
28parthenolide44 210.3IL6, IL8, MMP9
298-isoprostane449.2MMP9, IL8, IL6
30pentoxifylline44 1110.2IL1B, IL6, IL8
31ivig449.2MMP9, IL6, IL1B
32neopterin449.1IL8, IL6, IL1B
3315-deoxy-delta-12,14-prostaglandin j2449.1IL1B, IL6, IL8
34ciglitazone44 289.9IL1B, IL6, IL8, MMP9
35ccl344 289.9MMP9, IL8, IL6, IL1B
36pdtc448.9MMP9, IL8, IL6, IL1B
37leukotriene b444 61 2410.9MMP9, IL8, IL6, IL1B
38sp 60012544 619.9MMP9, IL8, IL6, IL1B
39troglitazone44 28 61 1111.9IL1B, IL6, IL8, MMP9
40herbimycin a44 619.9IL1B, IL6, IL8, MMP9
41hyaluronic acid44 249.9MMP9, IL8, IL6, IL1B
42curcumin448.9IL1B, IL6, IL8, MMP9
43aprotinin44 119.9IL6, IL8, MMP9
44rantes448.8IL1B, IL6, IL8, MMP9
45n acetylcysteine448.8MMP9, IL8, IL6, IL1B
46sb 20358044 619.8IL1B, IL6, IL8, MMP9
47pd 98,059448.7MMP9, IL8, IL6, IL1B
48ly294002448.7MMP9, IL8, IL6, IL1B
49actinomycin d448.5MMP9, IL8, IL6, IL1B
50genistein44 28 61 2 24 1113.2IL1B, IL6, IL8, MMP9

GO Terms for genes affiliated with Recurrent Corneal Erosion

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Cellular components related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1MMP9, IL8, IL6, IL1B, TGFBI
2extracellular spaceGO:0056157.8IL1B, IL6, IL8, MMP9, TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.7IL1B, MMP9
2neutrophil chemotaxisGO:0305939.6IL8, IL1B
3positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, IL6
4positive regulation of interleukin-6 productionGO:0327559.3IL1B, IL6
5positive regulation of T cell proliferationGO:0421029.1IL1B, IL6
6inflammatory responseGO:0069549.1IL1B, IL6, IL8
7negative regulation of cell proliferationGO:0082859.0IL1B, IL6, IL8

Products for genes affiliated with Recurrent Corneal Erosion

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Sources for Recurrent Corneal Erosion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet