MCID: RCR026
MIFTS: 21

Recurrent Hydatidiform Mole

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Recurrent Hydatidiform Mole

MalaCards integrated aliases for Recurrent Hydatidiform Mole:

Name: Recurrent Hydatidiform Mole 50 25
Familial Biparental Hydatidiform Mole 50 25
Familial Recurrent Hydatidiform Mole 50 25
Gestational Trophoblastic Disease 24 69
Frhm 50 25
Recurrent Gestational Trophoblastic Tumor 69
Gestational Trophoblastic Neoplasms 69
Hydatidiform Mole, Recurrent 24

Classifications:



Summaries for Recurrent Hydatidiform Mole

Genetics Home Reference : 25 Recurrent hydatidiform mole occurs when women have at least two abnormal pregnancies described as hydatidiform moles. A hydatidiform mole occurs early in pregnancy when an embryo does not fully develop and the placenta develops abnormally. The placenta is a solid structure in the uterus that normally provides nutrients to a growing fetus. If a hydatidiform mole occurs once, it is known a sporadic hydatidiform mole; if it happens again, the condition is known as recurrent hydatidiform mole.

MalaCards based summary : Recurrent Hydatidiform Mole, also known as familial biparental hydatidiform mole, is related to gestational trophoblastic tumor and hydatidiform mole, recurrent, 2. An important gene associated with Recurrent Hydatidiform Mole is NLRP7 (NLR Family Pyrin Domain Containing 7). The drugs Pemetrexed and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include placenta and uterus.

NIH Rare Diseases : 50 this condition doesn't have a summary yet. please see our page(s) on hydatidiform mole.

Related Diseases for Recurrent Hydatidiform Mole

Diseases related to Recurrent Hydatidiform Mole via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 gestational trophoblastic tumor 11.6
2 hydatidiform mole, recurrent, 2 11.2
3 hydatidiform mole, recurrent, 1 11.1
4 choriocarcinoma 9.9

Symptoms & Phenotypes for Recurrent Hydatidiform Mole

Drugs & Therapeutics for Recurrent Hydatidiform Mole

Drugs for Recurrent Hydatidiform Mole (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
3
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
4 Folic Acid Antagonists Phase 2
5 Nucleic Acid Synthesis Inhibitors Phase 2
6 Vitamin B Complex Phase 2
7 Folate Nutraceutical Phase 2
8 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
2 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2 pemetrexed disodium
3 Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles Recruiting NCT01008501

Search NIH Clinical Center for Recurrent Hydatidiform Mole

Genetic Tests for Recurrent Hydatidiform Mole

Genetic tests related to Recurrent Hydatidiform Mole:

id Genetic test Affiliating Genes
1 Hydatidiform Mole, Recurrent 24 NLRP7

Anatomical Context for Recurrent Hydatidiform Mole

MalaCards organs/tissues related to Recurrent Hydatidiform Mole:

39
Placenta, Uterus

Publications for Recurrent Hydatidiform Mole

Articles related to Recurrent Hydatidiform Mole:

(show all 26)
id Title Authors Year
1
Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform mole. ( 27621838 )
2016
2
Live births in women with recurrent hydatidiform mole and two NLRP7 mutations. ( 25982095 )
2015
3
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole. ( 26606510 )
2015
4
NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. ( 25358348 )
2015
5
Novel NLRP7 mutations in familial recurrent hydatidiform mole: are NLRP7 mutations a risk for recurrent reproductive wastage? ( 23880596 )
2013
6
Recurrent hydatidiform mole: detection of two novel mutations in the NLRP7 gene in two Egyptian families. ( 22770628 )
2012
7
The spectrum of NLRP7 mutations in French patients with recurrent hydatidiform mole. ( 21439709 )
2011
8
The genetics of recurrent hydatidiform moles in China: correlations between NLRP7 mutations, molar genotypes and reproductive outcomes. ( 21507883 )
2011
9
Screening for NLRP7 mutations in familial and sporadic recurrent hydatidiform moles: report of 2 Tunisian families. ( 21623199 )
2011
10
Recurrent hydatidiform mole: A case report of six consecutive molar pregnancies complicated by choriocarcinoma, and review of the literature. ( 22175045 )
2011
11
Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region. ( 19246479 )
2009
12
Genetic and epigenetic analysis of recurrent hydatidiform mole. ( 19309689 )
2009
13
Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. ( 16462743 )
2006
14
Analysis of the chromosomal region 19q13.4 in two Chinese families with recurrent hydatidiform mole. ( 16239310 )
2006
15
Familial recurrent hydatidiform mole: a review. ( 15457849 )
2004
16
Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. ( 12504931 )
2003
17
Extraluminal hyperechogenic echo detected by transvaginal ultrasonography as a prognostic factor in recurrent hydatidiform mole. ( 1283145 )
1992
18
Preimplantation diagnosis and recurrent hydatidiform mole. ( 1970075 )
1990
19
Recurrent hydatidiform mole: a report of a patient with 7 consecutive moles. ( 3233084 )
1988
20
Recurrent hydatidiform mole. Report of a case with five recurrences. ( 696258 )
1978
21
A case of recurrent hydatidiform mole. ( 1235019 )
1975
22
Recurrent hydatidiform mole. A case report of nine consecutive molar pregnancies. ( 4684203 )
1973
23
Recurrent hydatidiform mole: a report of five cases with review of the literature. ( 5357204 )
1969
24
Recurrent hydatidiform mole. Report of a case of four recurrences and a review of the literature. ( 5720477 )
1968
25
Recurrent hydatidiform mole. ( 20328493 )
1966
26
RECURRENT HYDATIDIFORM MOLE; REPORT OF A CASE. ( 14268024 )
1965

Variations for Recurrent Hydatidiform Mole

Expression for Recurrent Hydatidiform Mole

Search GEO for disease gene expression data for Recurrent Hydatidiform Mole.

Pathways for Recurrent Hydatidiform Mole

GO Terms for Recurrent Hydatidiform Mole

Sources for Recurrent Hydatidiform Mole

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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