RRP
MCID: RCR004
MIFTS: 42

Recurrent Respiratory Papillomatosis (RRP) malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

Aliases & Descriptions for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 50 56 69
Juvenile-Onset Recurrent Respiratory Papillomatosis 50
Adult-Onset Recurrent Respiratory Papillomatosis 50
Respiratory Papillomatosis, Recurrent 50
Laryngeal Papilloma, Recurrent 50
Juvenile Laryngeal Papilloma 50
Aorrp 50
Jorrp 50
Rrp 50

Characteristics:

Orphanet epidemiological data:

56
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 56  
Rare respiratory diseases


External Ids:

Orphanet 56 ORPHA60032
UMLS via Orphanet 70 C1168198
MESH via Orphanet 43 C535297

Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 50 recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to laryngeal papillomatosis and apple allergy. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Cidofovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes.

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 laryngeal papillomatosis 11.1
2 apple allergy 10.2 HLA-DQB1 HLA-DRB1
3 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
4 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
5 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
6 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
7 midline interhemispheric variant of holoprosencephaly 10.2 HLA-DQB1 HLA-DRB1
8 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 HLA-DRB1
9 lyme disease - neurological complications 10.2 HLA-DQB1 HLA-DRB1
10 distal trisomy 14q 10.2 HLA-DQB1 HLA-DRB1
11 learning disability 10.2 HLA-DQB1 HLA-DRB1
12 papilloma 10.2
13 linear lichen planus 10.2 HLA-DQB1 HLA-DRB1
14 caplan's syndrome 10.2 HLA-DRB1 IL2
15 night blindness 10.2 HLA-DQB1 HLA-DRB1
16 cervical adenoid basal carcinoma 10.2 HLA-DQB1 HLA-DRB1
17 neonatal antiphospholipid syndrome 10.2 HLA-DQB1 HLA-DRB1
18 myofibroma 10.2 HLA-DQB1 HLA-DRB1
19 oromandibular dystonia 10.2 HLA-DQB1 HLA-DRB1
20 cryptococcosis 10.2 HLA-DQB1 HLA-DRB1
21 bickerstaff brainstem encephalitis 10.2 HLA-DQB1 HLA-DRB1
22 cerebral sarcoidosis 10.2 HLA-DRB1 IL2
23 hepatitis 10.1 HLA-DRB1 IL2
24 squamous cell carcinoma 10.1
25 low anorectal malformation 10.1 HLA-DQB1 HLA-DRB1
26 endogenous depression 10.1 HLA-DRB1 IL2
27 ragweed sensitivity 10.1 HLA-DQB1 HLA-DRB1
28 folinic acid-responsive seizures 10.1 HLA-DQB1 HLA-DRB1
29 familial acute necrotizing encephalopathy 10.1 HLA-DRB1 IFNA2
30 diffuse scleroderma 10.1 HLA-DRB1 IL2
31 lymphangiectasia, intestinal 10.1 HLA-DQB1 HLA-DRB1
32 clostridium difficile colitis 10.0 HLA-DQB1 HLA-DRB1 IL2
33 multinodular goiter 10.0 EGFR IL2
34 heart conduction disease 10.0 HLA-DRB1 IL2
35 benign familial neonatal epilepsy 10.0 EGFR IFNA2
36 oropharynx cancer 10.0 IFNA2 IL2
37 laryngitis 10.0
38 advanced sleep phase syndrome, familial, 1 10.0 HLA-DQB1 HLA-DRB1 IL2
39 myxedema 10.0 EGFR IFNA2
40 anaerobic meningitis 10.0 EGFR HLA-DQB1 HLA-DRB1
41 choreatic disease 10.0 HLA-DQB1 HLA-DRB1
42 anterior corneal pigmentation 10.0 HLA-DQB1 HLA-DRB1 IFNA2
43 anterior foramen magnum meningioma 9.9 IFNA2 IL2
44 parasitic helminthiasis infectious disease 9.9 HLA-DQB1 HLA-DRB1
45 ovarian brenner tumor 9.9 EGFR IFNA2 IL2
46 gastroesophageal reflux 9.9
47 epidermodysplasia verruciformis 9.8
48 lung cancer 9.7
49 asthma 9.7
50 aspergillosis 9.7

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4,Phase 2 113852-37-2 60613
2 Anti-Infective Agents Phase 4,Phase 2
3 Antiviral Agents Phase 4,Phase 3,Phase 2
4 Vaccines Phase 3,Early Phase 1
5 Immunoglobulins Phase 3,Phase 2
6 Antibodies Phase 3,Phase 2
7
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
8
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
9
Pembrolizumab Approved Phase 2 1374853-91-4
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
11 Analgesics Phase 2
12 Cyclooxygenase 2 Inhibitors Phase 2
13 Cyclooxygenase Inhibitors Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Angiogenesis Inhibitors Phase 2,Phase 1
17 Angiogenesis Modulating Agents Phase 2,Phase 1
18 Anti-Inflammatory Agents Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2
20 Antirheumatic Agents Phase 2
21 Pharmaceutical Solutions Phase 2
22 Antibodies, Monoclonal Phase 2
23 Retinol palmitate Phase 2
24 retinol Nutraceutical Phase 2
25
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
26 vitamin d Phase 1
27 Trace Elements Phase 1
28 Ergocalciferols Phase 1
29 Vitamins Phase 1
30 Micronutrients Phase 1
31 Bone Density Conservation Agents Phase 1
32 Vitamin D2 Nutraceutical Phase 1
33 Calciferol Nutraceutical Phase 1
34 Pepsin A

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Use of Cidofovir for Recurrent Respiratory Papillomatosis Completed NCT00205374 Phase 4
2 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
3 4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3
6 Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2
7 A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2
8 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis Recruiting NCT02555800 Phase 2
9 Avelumab for People With Recurrent Respiratory Papillomatosis Recruiting NCT02859454 Phase 2
10 Study of Anti-PD-1 Therapy for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Recruiting NCT02632344 Phase 2
11 Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP) Completed NCT01020747 Phase 1
12 Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP) Not yet recruiting NCT02854761 Phase 1
13 Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease Withdrawn NCT00733252 Phase 1
14 Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP Completed NCT00550914
15 Human Papillomatosis Genotyping of Children in Thailand Completed NCT01304966
16 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
17 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358
18 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Recruiting NCT02592902
19 New Therapy of Laryngeal Papilloma In Children Terminated NCT00591305
20 Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis Withdrawn NCT00829608 Early Phase 1

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

39
Lung, T Cells, Testes, Trachea, Spinal Cord

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 368)
id Title Authors Year
1
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis. ( 27600632 )
2016
2
Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan. ( 26860235 )
2016
3
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ( 27074766 )
2016
4
Intersurgical interval increased with use of quadrivalent human papillomavirus vaccine (Gardasil) in a pediatric patient with recurrent respiratory papillomatosis: A case report. ( 27863633 )
2016
5
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. ( 26968061 )
2016
6
Impaired T Cell-dependent Humoral Immune Response Associated with Juvenile-onset Recurrent Respiratory Papillomatosis Progression. ( 27821867 )
2016
7
Is recurrent respiratory papillomatosis a manageable or curable disease? ( 26608928 )
2016
8
Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis. ( 26931553 )
2016
9
Multidimensional vocal assessment after laser treatment for recurrent respiratory papillomatosis. ( 27515839 )
2016
10
Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity. ( 27658005 )
2016
11
Prevalence and management of Recurrent Respiratory Papillomatosis (RRP) in the UK: cross sectional study. ( 27208548 )
2016
12
Response to letter to Editor: "The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors" by Michel R. M. San Giorgi et al. ( 27654254 )
2016
13
Safety of paediatric day-stay laryngeal surgery for recurrent respiratory papillomatosis. ( 26857327 )
2016
14
Quality of life of patients with recurrent respiratory papillomatosis. ( 27861969 )
2016
15
Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). ( 27759910 )
2016
16
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review. ( 27113025 )
2016
17
Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis. ( 27188508 )
2016
18
Acoustical and Perceptual Voice Profiling of Children With Recurrent Respiratory Papillomatosis. ( 26474713 )
2015
19
Age of onset of Recurrent Respiratory Papillomatosis: a distribution analysis. ( 26460806 )
2015
20
Molecular subtypification of human papillomavirus in male adult individuals with recurrent respiratory papillomatosis. ( 25906915 )
2015
21
Recurrent respiratory papillomatosis of the airway: The experience of an endoscopic unit. ( 25926371 )
2015
22
Recurrent respiratory papillomatosis: current and future perspectives. ( 25999724 )
2015
23
Recurrent respiratory papillomatosis progressing into squamous cell carcinoma in an HIV-positive patient. ( 26153613 )
2015
24
Nucleotide and phylogenetic analysis of human papillomavirus type 11 isolated from juvenile-onset recurrent respiratory papillomatosis in China. ( 26369639 )
2015
25
Viral load and mRNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis. ( 26010342 )
2015
26
Differences in Transcriptional Activity of Human Papillomavirus Type 6 Molecular Variants in Recurrent Respiratory Papillomatosis. ( 26151558 )
2015
27
FDG PET/CT Findings of Recurrent Respiratory Papillomatosis With Malignant Degeneration in the Lung. ( 26204210 )
2015
28
Recurrent respiratory papillomatosis in northern Sweden: clinical characteristics and practical guidance. ( 26004132 )
2015
29
Risk Factors for Dysplasia in Recurrent Respiratory Papillomatosis in an Adult and Pediatric Population. ( 26453486 )
2015
30
Trends in the management of recurrent respiratory papillomatosis in Japan. ( 25454156 )
2014
31
Recurrent respiratory papillomatosis: HPV genotypes and risk of high-grade laryngeal neoplasia. ( 24918765 )
2014
32
Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. ( 24955561 )
2014
33
Malignant degeneration of pulmonary juvenile-onset recurrent respiratory papillomatosis. ( 25487719 )
2014
34
Diagnosis and management of recurrent respiratory papillomatosis. ( 25229272 )
2014
35
Natural History and Malignant Transformation in Recurrent Respiratory Papillomatosis: Human Papillomavirus (HPV), Dysplasia and an Autopsy Review. ( 25353697 )
2014
36
The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors. ( 25351501 )
2014
37
Concurrent oral human papilloma virus infection in patients with recurrent respiratory papillomatosis: A preliminary study. ( 25059492 )
2014
38
Pulmonary papillomatosis: a rare case of recurrent respiratory papillomatosis presenting with multiple nodular and cavitary lesions. ( 25348187 )
2014
39
Risk factors for adult-onset recurrent respiratory papillomatosis. ( 24764146 )
2014
40
Voice and quality of life in patients with recurrent respiratory papillomatosis in a northern Sweden cohort. ( 24433057 )
2014
41
A case of recurrent respiratory papillomatosis with malignant transformation, HPV11 DNAemia, high L1 antibody titre and a fatal papillary endocardial lesion. ( 24942884 )
2014
42
Xenograft Model for Therapeutic Drug Testing in Recurrent Respiratory Papillomatosis. ( 25124839 )
2014
43
Chromoendoscopy Associated With Endoscopic Laryngeal Surgery: A New Technique for Treating Recurrent Respiratory Papillomatosis. ( 24674651 )
2014
44
Adult-Onset Recurrent Respiratory Papillomatosis: A Review of Disease Pathogenesis and Implications for Patient Counseling. ( 25393901 )
2014
45
Rapid response to systemic bevacizumab therapy in recurrent respiratory papillomatosis. ( 25289079 )
2014
46
Recurrent respiratory papillomatosis by HPV: review of the literature and update on the use of cidofovir. ( 25762828 )
2014
47
Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis. ( 24964770 )
2014
48
The incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis in the Free State province of South Africa and Lesotho. ( 25300480 )
2014
49
Estimating the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis in publicly and privately insured claims databases in the United States. ( 24722383 )
2014
50
Human papillomatosis genotyping and severity in patients with recurrent respiratory papillomatosis. ( 25391185 )
2014

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 EGFR HLA-DQB1 HLA-DRB1 IFNA2 IL2 KIR2DL2
2
Show member pathways
12.84 EGFR HLA-DQB1 HLA-DRB1 IL2
3
Show member pathways
12.77 EGFR HLA-DQB1 HLA-DRB1 IFNA2 IL2
4
Show member pathways
12.33 HLA-DQB1 HLA-DRB1 IL2
5
Show member pathways
12.28 HLA-DQB1 HLA-DRB1 IL2
6 12.27 EGFR IFNA2 IL2
7
Show member pathways
12.18 HLA-DQB1 HLA-DRB1 IFNA2
8
Show member pathways
12.15 IFNA2 IL2 KIR2DL2
9
Show member pathways
12.15 HLA-DQB1 HLA-DRB1 IFNA2 IL2
10 12.06 HLA-DQB1 HLA-DRB1 IL2
11
Show member pathways
12.01 HLA-DQB1 HLA-DRB1 IL2
12
Show member pathways
11.76 HLA-DQB1 HLA-DRB1 IFNA2 IL2 KIR2DL2
13 11.75 HLA-DQB1 HLA-DRB1 IFNA2
14
Show member pathways
11.5 EGFR HLA-DQB1 HLA-DRB1
15 11.49 IFNA2 IL2
16 11.46 HLA-DQB1 HLA-DRB1
17 11.41 EGFR IL2
18 11.32 HLA-DQB1 HLA-DRB1
19 11.24 EGFR IL2
20 11.21 EGFR IL2
21 10.96 EGFR IFNA2 IL2
22 10.91 HLA-DRB1 IL2
23 10.85 HLA-DRB1 IL2

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.43 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.37 HLA-DQB1 HLA-DRB1
4 endosome membrane GO:0010008 9.33 EGFR HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DQB1 HLA-DRB1
7 Golgi membrane GO:0000139 9.26 EGFR FUT8 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQB1 HLA-DRB1
2 positive regulation of inflammatory response GO:0050729 9.4 EGFR IL2
3 antigen processing and presentation GO:0019882 9.37 HLA-DQB1 HLA-DRB1
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 IFNA2 IL2
5 positive regulation of phosphorylation GO:0042327 9.26 EGFR IFNA2
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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