RRP
MCID: RCR004
MIFTS: 34

Recurrent Respiratory Papillomatosis (RRP) malady

Rare diseases, Respiratory diseases categories
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Summaries for Recurrent Respiratory Papillomatosis

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards: Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to ankylosing spondylitis. An important gene associated with Recurrent Respiratory Papillomatosis is KIR2DL5A (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A), and among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The compound mannose have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and spinal cord.

Wikipedia:65 Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis,... more...

Aliases & Classifications for Recurrent Respiratory Papillomatosis

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43NIH Rare Diseases, 49Orphanet, 62UMLS, 36MESH via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

recurrent respiratory papillomatosis 43 49 62
juvenile-onset recurrent respiratory papillomatosis 43
adult-onset recurrent respiratory papillomatosis 43
respiratory papillomatosis, recurrent 43
laryngeal papilloma, recurrent 43
juvenile laryngeal papilloma 43
jorrp 43
aorrp 43
rrp 43


External Ids:

MESH via Orphanet36 C535297
UMLS via Orphanet63 C1168198

Related Diseases for Recurrent Respiratory Papillomatosis

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17GeneCards, 18GeneDecks
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Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis10.1KIR2DL2

Symptoms for Recurrent Respiratory Papillomatosis

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Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Recurrent Respiratory Papillomatosis

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

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Anatomical Context for Recurrent Respiratory Papillomatosis

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33MalaCards
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MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

33
Lung, T cells, Spinal cord, Testes, Trachea

Animal Models for Recurrent Respiratory Papillomatosis or affiliated genes

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Publications for Recurrent Respiratory Papillomatosis

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52PubMed
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Articles related to Recurrent Respiratory Papillomatosis:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Identical human papillomavirus (HPV) genomic variants persist in recurrent respiratory papillomatosis for up to 22 years. (23204170)
2013
2
Photoangiolytic laser treatment of recurrent respiratory papillomatosis: a scaled assessment. (23102824)
2013
3
FRET-based detection and genotyping of HPV-6 and HPV-11 causing recurrent respiratory papillomatosis. (23473839)
2013
4
Surgical treatment and adjuvant therapies of recurrent respiratory papillomatosis. (24141682)
2013
5
HPV and recurrent respiratory papillomatosis: A modern virus and a serious disease with controversial management. (24139588)
2013
6
Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: A systematic review. (24367938)
2013
7
Clinical characteristics and HPV type in recurrent respiratory papillomatosis in Colombia. (24165718)
2013
8
Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis. (22566012)
2012
9
Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis. (23012897)
2012
10
Risk factors of juvenile onset recurrent respiratory papillomatosis in the lower respiratory tract. (23044312)
2012
11
Does food intolerance play a role in recurrent respiratory papillomatosis? (22311847)
2012
12
Natural progression of dysplasia in adult recurrent respiratory papillomatosis. (21493426)
2011
13
Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis. (21531896)
2011
14
Recurrent respiratory papillomatosis: an overview. (20517629)
2010
15
Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. (20553528)
2010
16
The role of HPV type in Recurrent Respiratory Papillomatosis. (19800138)
2010
17
Epidemiology of recurrent respiratory papillomatosis. (20553527)
2010
18
Palliative aspects of recurrent respiratory papillomatosis. (19134490)
2009
19
High-resolution ultrasound in the evaluation of pediatric recurrent respiratory papillomatosis. (19289702)
2009
20
Pharmacotherapy of recurrent respiratory papillomatosis: an expert opinion. (19284366)
2009
21
Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. (19193450)
2009
22
Commentary on "Dysplasia in adults with recurrent respiratory papillomatosis: incidence and risk factors". (19708486)
2009
23
Time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. (18174855)
2008
24
Recurrent respiratory papillomatosis complicated by aspergillosis: a case report with review of literature. (18296803)
2008
25
Recurrent respiratory papillomatosis in pregnancy: a case of emergent airway management. (18561109)
2008
26
Protein expression of the tumor suppressors p16INK4A and p53 and disease progression in recurrent respiratory papillomatosis. (17277618)
2007
27
Unusual malignant transformation of juvenile recurrent respiratory papillomatosis. (17275567)
2007
28
Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis? (17560665)
2007
29
CR12/339--Nebulized cidofovir for recurrent respiratory papillomatosis: a case report. (17036412)
2006
30
Identification of HPV DNA in patients with juvenile-onset recurrent respiratory papillomatosis using SYBR Green real-time PCR. (16137771)
2006
31
Cidofovir for the treatment of recurrent respiratory papillomatosis: a review of the literature. (16006276)
2005
32
HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis. (15336778)
2004
33
Efficacy of cidofovir injection for the treatment of recurrent respiratory papillomatosis. (15567056)
2004
34
Pulsed-dye laser in the treatment of recurrent respiratory papillomatosis of the larynx. (14503089)
2003
35
Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. (12925342)
2003
36
Powered instrumentation in the treatment of recurrent respiratory papillomatosis: an alternative to the carbon dioxide laser. (11926919)
2002
37
Recurrent respiratory papillomatosis. (10851821)
2000
38
Recurrent respiratory papillomatosis of the larynx: current diagnosis and treatment. (10984775)
2000
39
Pathological case of the month. Recurrent respiratory papillomatosis. (9559722)
1998
40
Risk factors for juvenile onset recurrent respiratory papillomatosis. (9613648)
1998
41
Treatment of recurrent respiratory papillomatosis with indole-3-carbinol. (9242883)
1997
42
Tracheotomy in children with juvenile-onset recurrent respiratory papillomatosis: the Children's Hospital of Pittsburgh experience. (8546418)
1996
43
Role of cesarean section in prevention of recurrent respiratory papillomatosis--is there one? (8882107)
1996
44
Recurrent respiratory papillomatosis. (8869953)
1996
45
Acyclovir in the treatment of recurrent respiratory papillomatosis. A pilot study. (8154772)
1994
46
13-Cis-retinoic acid plus interferon-alpha 2a in recurrent respiratory papillomatosis. (8182767)
1994
47
Isotretinoin therapy for recurrent respiratory papillomatosis. (8166969)
1994
48
Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm. (7917213)
1994
49
Complications of laser surgery for recurrent respiratory papillomatosis. (3688749)
1987
50
Further observations on the treatment of recurrent respiratory papillomatosis with interferon: a comparison of sources. (6194728)
1983

Variations for Recurrent Respiratory Papillomatosis

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Expression for genes affiliated with Recurrent Respiratory Papillomatosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for genes affiliated with Recurrent Respiratory Papillomatosis

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50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.6KIR2DL1, KIR2DL4, KIR2DL2, KIR2DS3
28.6KIR2DS3, KIR2DL2, KIR2DL4, KIR2DL1
3
Show member pathways
8.5KIR2DS3, KIR2DL2, KIR2DL1, KIR3DS1
4
Show member pathways
Immune response CD16 signaling in NK cells60
8.2KIR2DL1, KIR2DL5A, KIR2DL4, KIR2DL2, KIR2DS3
5
Show member pathways
8.2KIR2DS3, KIR2DL2, KIR2DL4, KIR2DL5A, KIR2DL1

Compounds for genes affiliated with Recurrent Respiratory Papillomatosis

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45Novoseek
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Compounds related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannose459.2KIR2DL2, DPM1

GO Terms for genes affiliated with Recurrent Respiratory Papillomatosis

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16Gene Ontology
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Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.1KIR3DS1, KIR2DL1, KIR2DL4, KIR2DS3
2plasma membraneGO:0058868.0KIR3DS1, KIR2DL1, KIR2DL5A, KIR2DL4, KIR2DL2

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3KIR3DS1, KIR2DL1
2cellular defense responseGO:0069689.2KIR2DL4, KIR2DS3
3regulation of immune responseGO:0507768.9KIR2DL1, KIR2DL4, KIR2DL2

Products for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources for Recurrent Respiratory Papillomatosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet