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AORRP
MCID: RCR004
MIFTS: 51

Recurrent Respiratory Papillomatosis (AORRP) malady

Respiratory category
42 genes, 4 tissues, 151 related diseases, clinical trials.

Summaries for Recurrent Respiratory Papillomatosis

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Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards: Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to squamous cell carcinoma and asthma. An important gene associated with Recurrent Respiratory Papillomatosis is DPM1 (dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit), and among its related pathways are Colorectal Cancer Metastasis and Glioma. The compounds resveratrol and etoposide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, lung and t cells, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Wikipedia:64 Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis,... more...

Aliases & Classifications for Recurrent Respiratory Papillomatosis

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Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 36MESH via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

recurrent respiratory papillomatosis 43 49 61
juvenile-onset recurrent respiratory papillomatosis 43
adult-onset recurrent respiratory papillomatosis 43
juvenile laryngeal papilloma 43
jorrp 43
aorrp 43


External Ids:

MESH via Orphanet36 C535297
UMLS via Orphanet62 C1168198

Related Diseases for Recurrent Respiratory Papillomatosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.8UGCG, EGFR, CDKN2A, CDKN1A, TAP1, RAC1
2asthma30.2HLA-DRB1, TAP1, HLA-DQA1
3squamous papillomatosis10.6
4squamous cell papilloma10.6
5laryngeal papillomatosis10.4
6rubella10.2
7tonsil cancer10.2
8lemierre's syndrome10.2
9gastroesophageal reflux disease10.2
10measles10.2
11bronchogenic carcinoma10.2
12mumps10.2
13aspergillosis10.2
14lichen planus10.0IFNA2
15influenza10.0TAP1
16hemangioma10.0IFNA2
17thyroiditis10.0HLA-DRB1
18cervical intraepithelial neoplasia10.0CDKN2A
19hepatitis10.0IFNA2
20ulcerative colitis10.0TP53
21myeloid leukemia10.0CDKN1A
22allergic rhinitis10.0TAP1
23neuroblastoma10.0TP53
24pituitary adenoma10.0RAC1
25tongue cancer10.0CDKN1A
26gallbladder cancer10.0TP53
27malignant mesothelioma10.0CDKN2A
28smooth muscle tumor10.0ESR1
29leprosy10.0HLA-DRB1
30leiomyoma10.0ESR1
31ependymoma10.0EGFR
32leiomyosarcoma10.0TP53
33pituitary tumors10.0ESR1
34urticaria10.0PTGS2
35liver cirrhosis10.0IFNA2, HLA-DRB1
36osteoarthritis10.0PTGS2
37focal epithelial hyperplasia10.0IFNA2
38adenocarcinoma in situ10.0CDKN2A
39angiomyolipoma10.0ESR1
40chondrosarcoma10.0EXT1
41hepatitis c10.0HLA-DRB1, IFNA2
42psoriasis10.0HLA-DRB1, TAP1
43myeloma10.0IFNA2, CDKN1A
44pemphigus foliaceus10.0HLA-DRB1
45cryoglobulinemic vasculitis10.0IFNA2
46benign mesothelioma10.0TP53
47cervical squamous cell carcinoma10.0CDKN2A, CDKN1A
48eosinophilia10.0IFNA2
49oral cavity cancer10.0TP53
50bilateral breast cancer10.0ESR1

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to recurrent respiratory papillomatosis

Clinical Features for Recurrent Respiratory Papillomatosis

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Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Recurrent Respiratory Papillomatosis

Drug clinical trials:

Search ClinicalTrials for Recurrent Respiratory Papillomatosis

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Search CenterWatch for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

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Anatomical Context for Recurrent Respiratory Papillomatosis

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33MalaCards
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MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

33
Spinal cord, Lung, T cells, Trachea

Animal Models for Recurrent Respiratory Papillomatosis or affiliated genes

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Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Recurrent Respiratory Papillomatosis:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
limbs/digits/tail phenotype
MP:000537110.7EXT1
2
embryogenesis phenotype
MP:000538010.5ERBB2, RAC1
3
skeleton phenotype
MP:000539010.5HEXB, CDKN1A
4
adipose tissue phenotype
MP:000537510.4HEXB
5
endocrine/exocrine gland phenotype
MP:000537910.3CDKN1A, CDKN2A, RAC1, TP53
6
nervous system phenotype
MP:000363110.3CDKN1A, HEXB, HLA-DQB1, ERBB2, TAP1
7
integument phenotype
MP:001077110.2TP53, PTGS2, TAP1, CDKN1A, CDKN2A
8
tumorigenesis
MP:000200610.1ERBB2, TAP1, CDKN1A, CDKN2A, EXT1, EGFR
9
homeostasis/metabolism phenotype
MP:000537610.0HEXB, HLA-DQB1, UGCG, ESR1
10
renal/urinary system phenotype
MP:000536710.0EGFR, HLA-DQB1, HEXB
11
muscle phenotype
MP:000536910.0TP53, HEXB, HLA-DQB1, RAC1, CDKN1A, CDKN2A
12
vision/eye phenotype
MP:00053919.8EXT1, HEXB, EGFR
13
respiratory system phenotype
MP:00053889.7FUT8, ERBB2, PTGS2, CDKN1A, EGFR, HLA-DQB1
14
reproductive system phenotype
MP:00053899.7CDKN1A, RAC1, PTGS2, TP53, HEXB, EGFR
15
craniofacial phenotype
MP:00053829.7RAC1, ERBB2, CDKN1A, EGFR, HEXB, EXT1
16
no phenotypic analysis
MP:00030129.7CDKN1A, CDKN2A, EGFR, UGCG, EXT1, PTGS2
17
liver/biliary system phenotype
MP:00053709.7CDKN2A, EGFR, HLA-DQB1, HEXB, TP53, ESR1
18
digestive/alimentary phenotype
MP:00053819.6CDKN2A, PTGS2, ESR1, ERBB2, CDKN1A, EGFR
19
cardiovascular system phenotype
MP:00053859.4ESR1, ERBB2, PTGS2, RAC1, CDKN1A, EGFR
20
hematopoietic system phenotype
MP:00053979.4TP53, HLA-DQA1, HEXB, PTGS2, RAC1, TAP1
21
immune system phenotype
MP:00053879.4TP53, PTGS2, RAC1, CDKN2A, TAP1, CDKN1A
22
behavior/neurological phenotype
MP:00053869.3HEXB, HLA-DQB1, UGCG, CDKN2A, TP53, ESR1
23
cellular phenotype
MP:00053849.2TP53, ERBB2, ESR1, CDKN1A, PTGS2, TAP1
24
growth/size phenotype
MP:00053789.2HLA-DQB1, PTGS2, FUT8, ESR1, ERBB2, RAC1
25
mortality/aging
MP:00107689.1TP53, EXT1, HEXB, HLA-DQB1, ERBB2, FUT8

Publications for Recurrent Respiratory Papillomatosis

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51PubMed
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Articles related to Recurrent Respiratory Papillomatosis:

(show top 50)    (show all 315)
idTitleAuthorsYear
1
Response to Dikkers letter to the editor regarding "systematic review of intralesional cidofovir dosing regimens in the treatment of recurrent respiratory papillomatosis". (24021212)
2013
2
FRET-based detection and genotyping of HPV-6 and HPV-11 causing recurrent respiratory papillomatosis. (23473839)
2013
3
Rare case of malignant transformation of recurrent respiratory papillomatosis associated with human papillomavirus type 6 infection and p53 overexpression. (23641321)
2013
4
Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis. (22566012)
2012
5
Recurrent respiratory papillomatosis: the Korle-Bu experience. (22605888)
2012
6
Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa. (21875449)
2012
7
Juvenile-onset recurrent respiratory papillomatosis. (22472239)
2012
8
UK needs vaccine to protect against HPV types causing recurrent respiratory papillomatosis. (22008803)
2011
9
Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. (22097147)
2011
10
Recurrent respiratory papillomatosis: an overview. (20517629)
2010
11
Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. (19861144)
2010
12
Adjuvant antiviral therapy for recurrent respiratory papillomatosis. (20091568)
2010
13
Recurrent respiratory papillomatosis presenting to an emergency department. (19855282)
2010
14
High-resolution ultrasound in the evaluation of pediatric recurrent respiratory papillomatosis. (19289702)
2009
15
Commentary on "Dysplasia in adults with recurrent respiratory papillomatosis: incidence and risk factors". (19708486)
2009
16
Recurrent respiratory papillomatosis with lung involvement. (19517378)
2009
17
Regression of recurrent respiratory papillomatosis with celecoxib and erlotinib combination therapy. (19736197)
2009
18
Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patients. (19235575)
2009
19
Recurrent respiratory papillomatosis complicated by aspergillosis: a case report with review of literature. (18296803)
2008
20
Recurrent respiratory papillomatosis in pregnancy: a case of emergent airway management. (18561109)
2008
21
18F FDG-PET/CT findings in recurrent respiratory papillomatosis. (18600423)
2008
22
Severity of juvenile onset recurrent respiratory papillomatosis is not associated with socioeconomic status in a setting of universal health care. (17428551)
2007
23
An epigenetically derived monoclonal origin for recurrent respiratory papillomatosis. (17638782)
2007
24
Virtual bronchoscopy for diagnosis of recurrent respiratory papillomatosis. (16801040)
2006
25
Anesthetic management for laser excision of recurrent respiratory papillomatosis in a third trimester parturient. (16427531)
2005
26
Recurrent respiratory papillomatosis: pathogenesis to treatment. (16282764)
2005
27
Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation. (15532092)
2005
28
American Society of Pediatric Otolaryngology members' experience with recurrent respiratory papillomatosis and the use of adjuvant therapy. (15381589)
2004
29
Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosis. (15451182)
2004
30
Analysis of a staging assessment system for prediction of surgical interval in recurrent respiratory papillomatosis. (15533560)
2004
31
Current diagnostic and management trends for recurrent respiratory papillomatosis. (15548913)
2004
32
Recurrent respiratory papillomatosis in a survivor of extreme prematurity. (15334516)
2004
33
STAT3 activation in recurrent respiratory papillomatosis. (15381590)
2004
34
Overview of recurrent respiratory papillomatosis. (14631175)
2003
35
Molecular events in the progression of recurrent respiratory papillomatosis to carcinoma. (12296755)
2002
36
Novel treatments for recurrent respiratory papillomatosis. (12150707)
2002
37
Tracheobronchial extension of recurrent respiratory papillomatosis. (11007082)
2000
38
Treatment of recurrent respiratory papillomatosis with indole-3-carbinol. (9242883)
1997
39
Demonstration of antibodies against human papillomavirus type-11 E6 and L2 proteins in patients with recurrent respiratory papillomatosis. (9134142)
1997
40
Recurrent respiratory papillomatosis. (8973518)
1996
41
Index of suspicion. Case 2. Diagnosis: recurrent respiratory papillomatosis. (7855026)
1995
42
CT findings of malignant change in recurrent respiratory papillomatosis. (7560330)
1995
43
13-Cis-retinoic acid plus interferon-alpha 2a in recurrent respiratory papillomatosis. (8182767)
1994
44
Recurrent respiratory papillomatosis: juvenile versus adult forms. (8189980)
1994
45
Alpha-interferon (Wellferon) as an adjunct to standard surgical therapy in the management of recurrent respiratory papillomatosis. (3408112)
1988
46
Treatment of recurrent respiratory papillomatosis with human leukocyte interferon. Results of a multicenter randomized clinical trial. (3398891)
1988
47
Side effects and toxicity of interferon in the treatment of recurrent respiratory papillomatosis. (3674659)
1987
48
Recurrent respiratory papillomatosis in children: a retrospective study of management and complications. (3769839)
1986
49
Malignant transformation in non-irradiated recurrent respiratory papillomatosis. (4021682)
1985
50
Recurrent respiratory papillomatosis: management with the CO2 laser. (949157)
1976

Genetic Variations for Recurrent Respiratory Papillomatosis

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Expression for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 56SinoBiological, 50PharmGKB, 53R&D Systems
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Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Colorectal Cancer Metastasis52
10.3EGFR
2
Glioma30
Hide members
10.2TP53, CDKN1A
3
Staphylococcus aureus infection30
10.2HLA-DQB1, HLA-DQA1, HLA-DRB1
4
Immune response Antigen presentation by MHC class II
Hide members
10.2HLA-DQB1, HLA-DQA1, HLA-DRB1
5
Translocation of ZAP-70 to Immunological synapse54
Hide members
10.2HLA-DRB1, HLA-DQB1, HLA-DQA1
6
Inhibition of Ribosome Biogenesis by p14(ARF)52
10.1CDKN2A, RAC1, TP53
7
TP53 network38
10.1TP53, CDKN2A, CDKN1A
8
Transcription P53 signaling pathway
Hide members
10.1TP53, CDKN1A, CDKN2A
9
Agrin Interactions at Neuromuscular Junction52
10.1EGFR, ERBB2, RAC1
10
Allograft rejection30
Hide members
10.1IFNA2, HLA-DQA1, HLA-DRB1, HLA-DQB1
11
Tuberculosis30
10.1HLA-DRB1, HLA-DQB1, IFNA2, HLA-DQA1
12
Immune response NFAT in immune response
Hide members
10.1RAC1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13
Immune response ICOS pathway in T-helper cell
Hide members
10.1HLA-DRB1, HLA-DQA1, RAC1, HLA-DQB1
14
CD28 co-stimulation54
Hide members
10.1RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
15
ICos-ICosL Pathway in T-Helper Cell52
Hide members
10.1HLA-DQA1, RAC1, HLA-DRB1, HLA-DQB1
16
Immune response T cell receptor signaling pathway12
10.1HLA-DRB1, HLA-DQB1, HLA-DQA1, RAC1
17
Signaling mediated by p38-alpha and p38-beta38
10.0TP53, ESR1, PTGS2
18
G-protein signaling N-RAS regulation pathway12
10.0HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR
19
Leishmaniasis30
Hide members
10.0HLA-DQB1, HLA-DRB1, HLA-DQA1, PTGS2
20
Direct p53 effectors38
10.0TAP1, CDKN1A, EGFR, TP53
21
Hepatitis C30
10.0TP53, CDKN1A, EGFR, IFNA2
22
Fc epsilon receptor (FCERI) signaling54
Hide members
10.0ERBB2, RAC1, CDKN1A, EGFR
23
Alpha6-Beta4 Integrin Signaling Pathway38
10.0CDKN1A, EGFR, RAC1, ERBB2
24
Phagosome30
10.0HLA-DQA1, TAP1, HLA-DRB1, RAC1, HLA-DQB1
25
EGFR Signaling Pathway56
10.0TP53, ERBB2, RAC1, EGFR
26
ErbB signaling pathway30
Hide members
9.9TP53, CDKN1A, ERBB2, EGFR
27
Akt Signaling Pathway 53
9.9ERBB2, CDKN1A, TP53, EGFR
28
Integrated Breast Cancer Pathway38
9.9EGFR, ESR1, TP53, RAC1
29
Epstein-Barr virus infection30
9.9TP53, CDKN1A, HLA-DRB1, HLA-DQB1, HLA-DQA1
30
PKC-Theta Pathway52
Hide members
9.9PTGS2, HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1
31
PI3K-Akt signaling pathway30
9.9IFNA2, RAC1, CDKN1A, EGFR, TP53
32
Wnt Signaling Pathway38
Hide members
9.9ERBB2, RAC1, CDKN1A, CDKN2A, TP53
33
Glioblastoma Multiforme52
9.8EGFR, TP53, RAC1, CDKN1A, CDKN2A
34
Endometrial cancer30
Hide members
9.8CDKN1A, EGFR, RAC1, ERBB2, TP53
35
Influenza A30
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9.8HLA-DRB1, IFNA2, TP53, TAP1, HLA-DQA1, HLA-DQB1
36
PIP3 activates AKT signaling54
Hide members
9.8RAC1, ERBB2, CDKN1A, EGFR, ESR1
37
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.8PTGS2, ERBB2, EGFR, RAC1, ESR1
38
HTLV-I infection30
9.8TP53, CDKN1A, CDKN2A, HLA-DQA1, HLA-DQB1, HLA-DRB1
39
ErbB4 Pathway52
Hide members
9.8HLA-DQB1, EGFR, ERBB2, RAC1, HLA-DRB1, HLA-DQA1
40
Actin Nucleation by ARP-WASP Complex52
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9.8RAC1, HLA-DRB1, HLA-DQB1, HLA-DQA1, EGFR, ERBB2
41
GPCR Pathway52
Hide members
9.7HLA-DRB1, ERBB2, HLA-DQA1, HLA-DQB1, ESR1, TP53
42
Chronic myeloid leukemia30
Hide members
9.7EGFR, TP53, ERBB2, CDKN2A, CDKN1A, RAC1
43
Immune System54
Hide members
9.7HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR, CDKN1A, TAP1
44
Proteoglycans in cancer30
9.7TP53, ERBB2, RAC1, CDKN1A, EGFR, ESR1
45
Rho Family GTPases52
Hide members
9.7CDKN1A, RAC1, PTGS2, ERBB2, ESR1, TP53
46
MicroRNAs in cancer30
9.7EGFR, CDKN2A, CDKN1A, PTGS2, ERBB2, TP53
47
Development HGF signaling pathway12
Hide members
9.7PTGS2, ERBB2, ESR1, TP53, RAC1, EGFR
48
PEDF Induced Signaling52
Hide members
9.6RAC1, EGFR, IFNA2, CDKN1A, TP53, PTGS2
49
Pathways in cancer30
9.6CDKN2A, EGFR, TP53, ERBB2, PTGS2, RAC1
50
Integrated Pancreatic Cancer Pathway38
9.5ERBB2, PTGS2, RAC1, TP53, EGFR, CDKN1A

Compounds for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1resveratrol45 60 11 2413.7ERBB2
2etoposide45 50 60 1113.4ERBB2, UGCG, IFNA2
3acnu4510.4CDKN2A, CDKN1A, TP53
4hrgbeta14510.4ERBB2, CDKN1A, EGFR
5valine4510.4CDKN2A, TAP1, RAC1, ERBB2
6bcnu4510.4TP53, IFNA2, EGFR, CDKN2A
7megestrol acetate4510.4IFNA2, ERBB2, ESR1
8hpvs4510.4TP53, CDKN2A, CDKN1A
9tamoxifen45 50 29 1113.4ERBB2, EGFR, UGCG, CDKN1A
10exemestane50 45 60 1113.3ESR1, ERBB2, EGFR, PTGS2
11temozolomide45 1111.3CDKN1A, TP53, CDKN2A, EGFR, IFNA2
12anastrozole45 1111.3ESR1, ERBB2, EGFR
13suberoylanilide hydroxamic acid4510.3TP53, CDKN1A, EGFR, ERBB2
14irinotecan45 50 1112.3CDKN1A, ERBB2, TP53, CDKN2A, EGFR
15oxaliplatin45 50 1112.3EGFR, CDKN1A, TP53, ERBB2
16taxane4510.2ESR1, CDKN1A, ERBB2, EGFR, TP53
17flavopiridol45 1111.2EGFR, CDKN2A, CDKN1A, ERBB2, TP53
183,3-diindolylmethane4510.2CDKN1A, ESR1, TP53
19n-(4-hydroxyphenyl)retinamide4510.2UGCG, CDKN1A, TP53, ERBB2, ESR1
20lapatinib45 50 1112.2ESR1, HLA-DQA1, EGFR, TAP1, ERBB2, HLA-DRB1
21gefitinib45 50 1112.2PTGS2, ESR1, CDKN1A, EGFR, ERBB2
22gemcitabine45 50 1112.2CDKN1A, PTGS2, TP53, EGFR, ERBB2
23geldanamycin45 50 60 1113.2EGFR, CDKN1A, ERBB2, ESR1, TP53
24celecoxib45 60 29 50 11 2415.2PTGS2, ERBB2, EGFR, CDKN1A
25adriamycin4510.2CDKN1A, UGCG, CDKN2A, ERBB2, TP53
26thymidylate4510.2EGFR, TP53, CDKN2A, ERBB2, CDKN1A, IFNA2
27bortezomib45 1111.2EGFR, CDKN1A, ERBB2, TP53
28carboplatin45 50 1112.1TP53, EGFR, IFNA2, ERBB2
29agar4510.1IFNA2, ERBB2, RAC1, CDKN1A, CDKN2A, EGFR
30mg 13245 6011.1CDKN2A, TP53, ESR1, CDKN1A, EGFR
31docetaxel45 50 60 1113.1CDKN1A, EGFR, ERBB2, ESR1, TP53, CDKN2A
32curcumin4510.1ERBB2, EGFR, CDKN1A, PTGS2, TP53
33tetracycline45 1111.1CDKN2A, RAC1, ERBB2, EGFR
345fluorouracil4510.0ESR1, ERBB2, CDKN1A, CDKN2A, EGFR, IFNA2
35hydroxyurea45 50 1112.0TP53, CDKN1A, CDKN2A, IFNA2
36toremifene45 1111.0ESR1, ERBB2, IFNA2
37n acetylcysteine4510.0CDKN2A, EGFR, ERBB2, CDKN1A, PTGS2, TP53
38paraffin4510.0ESR1, TP53, ERBB2, CDKN1A, CDKN2A, HLA-DQA1
39ly294002459.9PTGS2, ERBB2, RAC1, CDKN1A, EGFR, TP53
40oligonucleotide459.9CDKN1A, CDKN2A, TAP1, RAC1, HLA-DQB1, HLA-DRB1
41genistein45 29 60 2 11 2414.9RAC1, CDKN1A, PTGS2, EGFR, ERBB2, ESR1
42retinoid459.9EGFR, CDKN1A, TP53, ESR1, IFNA2
43progesterone45 60 29 11 2413.9IFNA2, EGFR, CDKN2A, CDKN1A, ESR1, ERBB2
44doxorubicin45 50 1111.9ESR1, CDKN1A, CDKN2A, EGFR, UGCG, IFNA2
45paclitaxel45 50 1111.9CDKN2A, EGFR, UGCG, CDKN1A, RAC1, ERBB2
46olomoucine45 1110.8CDKN1A, TP53, CDKN2A
47cisplatin45 50 60 1112.8RAC1, CDKN1A, EGFR, TP53, PTGS2, CDKN2A
48vegf459.7PTGS2, RAC1, CDKN1A, IFNA2, EGFR, CDKN2A
49retinoic acid45 2410.7IFNA2, UGCG, RAC1, CDKN1A, ESR1, EGFR
50arginine459.6HLA-DQA1, HLA-DRB1, CDKN2A, RAC1, EXT1, ERBB2

GO Terms for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.4HLA-DQA1, HLA-DRB1, HLA-DQB1
2clathrin-coated endocytic vesicle membraneGO:03066910.3HLA-DQA1, HLA-DQB1, HLA-DRB1
3integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-DRB1, HLA-DQA1, HLA-DQB1
4transport vesicle membraneGO:03065810.2HLA-DQB1, HLA-DQA1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:01250710.2HLA-DRB1, HLA-DQB1, HLA-DQA1
6endocytic vesicle membraneGO:03066610.2HLA-DQB1, HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:03258810.1HLA-DQB1, HLA-DRB1, HLA-DQA1
8membraneGO:0160209.8HLA-DQB1, UGCG, EGFR, DPM1, ESR1, HLA-DRB1
9endosome membraneGO:0100089.7HLA-DQB1, EGFR, ERBB2, HLA-DQA1
10Golgi membraneGO:0001399.6FUT8, HS3ST3A1, EXT1, HLA-DQB1, HLA-DRB1, HLA-DQA1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DQB1, HLA-DRB1
2negative regulation of immature T cell proliferation in thymusGO:03308810.5ERBB2, CDKN2A
3humoral immune response mediated by circulating immunoglobulinGO:00245510.4HLA-DRB1, HLA-DQB1
4interferon-gamma-mediated signaling pathwayGO:06033310.4HLA-DQA1, HLA-DQB1, HLA-DRB1
5T cell costimulationGO:03129510.4HLA-DQA1, RAC1, HLA-DQB1, HLA-DRB1
6positive regulation of fibroblast proliferationGO:04814610.3ESR1, CDKN1A, EGFR
7positive regulation of nitric oxide biosynthetic processGO:04542910.3ESR1, EGFR, PTGS2
8mitotic cell cycle arrestGO:07185010.3TP53, CDKN1A
9cytokine-mediated signaling pathwayGO:01922110.3HLA-DQA1, HLA-DRB1, IFNA2, HLA-DQB1
10negative regulation of gene expressionGO:01062910.3ESR1, IFNA2, CDKN1A
11Fc-epsilon receptor signaling pathwayGO:03809510.2RAC1, CDKN1A, EGFR, ERBB2
12replicative senescenceGO:09039910.2CDKN2A, TP53
13Ras protein signal transductionGO:00726510.2CDKN2A, CDKN1A, TP53
14antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.2HLA-DQA1, HLA-DRB1, HLA-DQB1
15T cell receptor signaling pathwayGO:05085210.1HLA-DQA1, HLA-DRB1, HLA-DQB1
16neurotrophin TRK receptor signaling pathwayGO:0480119.7EGFR, CDKN1A, RAC1, ERBB2

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.3HLA-DQB1, HLA-DRB1, HLA-DQA1
2epidermal growth factor-activated receptor activityGO:00500610.3ERBB2, EGFR
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2A, CDKN1A
4MDM2/MDM4 family protein bindingGO:09737110.2TP53, CDKN2A
5nitric-oxide synthase regulator activityGO:03023510.1EGFR, ESR1
6enzyme bindingGO:0198999.9PTGS2, RAC1, ESR1, TP53, EGFR
7protein heterodimerization activityGO:0469829.9ERBB2, EGFR, TP53, HEXB, EXT1
8receptor signaling protein tyrosine kinase activityGO:0047169.9EGFR, ERBB2

Products for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources for Recurrent Respiratory Papillomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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