MCID: RCR004
MIFTS: 47

Recurrent Respiratory Papillomatosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

MalaCards integrated aliases for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 49 55 69
Juvenile-Onset Recurrent Respiratory Papillomatosis 49
Adult-Onset Recurrent Respiratory Papillomatosis 49
Respiratory Papillomatosis, Recurrent 49
Laryngeal Papilloma, Recurrent 49
Juvenile Laryngeal Papilloma 49
Aorrp 49
Jorrp 49
Rrp 49

Characteristics:

Orphanet epidemiological data:

55
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 55  
Rare respiratory diseases


External Ids:

Orphanet 55 ORPHA60032
MESH via Orphanet 42 C535297
UMLS via Orphanet 70 C1168198
UMLS 69 C1168198

Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 49 Recurrent respiratory papillomatosis (RRP) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). Although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. The tumors may vary in size and grow very quickly. They often grow back even when removed. RRP is caused by two types of human papillomavirus (HPV), called HPV 6 and HPV 11. Last updated: 11/21/2011

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to mumps and diabetes mellitus. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Cidofovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and t cells.

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 mumps 30.2 HLA-DRB1 IL2
2 diabetes mellitus 29.3 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 laryngeal papillomatosis 11.1
4 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
5 metal allergy 10.4 HLA-DQB1 HLA-DRB1
6 lichen planopilaris 10.3 HLA-DQB1 HLA-DRB1
7 type ii mixed cryoglobulinemia 10.3 HLA-DQB1 HLA-DRB1
8 idiopathic inflammatory myopathy 10.3 HLA-DQB1 HLA-DRB1
9 chronic beryllium disease 10.3 HLA-DQB1 HLA-DRB1
10 autoimmune pancreatitis 10.3 HLA-DQB1 HLA-DRB1
11 pityriasis rosea 10.3 HLA-DQB1 HLA-DRB1
12 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1
13 whipple disease 10.3 HLA-DQB1 HLA-DRB1
14 pediatric multiple sclerosis 10.3 HLA-DQB1 HLA-DRB1
15 osteonecrosis of the jaw 10.3 HLA-DQB1 HLA-DRB1
16 cystic echinococcosis 10.3 HLA-DQB1 HLA-DRB1
17 berylliosis 10.3 HLA-DRB1 IL2
18 peanut allergy 10.3 HLA-DQB1 HLA-DRB1
19 panuveitis 10.3 HLA-DQB1 HLA-DRB1
20 hypersomnia 10.3 HLA-DQB1 HLA-DRB1
21 papilloma 10.3
22 pure red-cell aplasia 10.3 HLA-DRB1 IL2
23 severe hemophilia a 10.3 HLA-DQB1 HLA-DRB1
24 ocular cicatricial pemphigoid 10.3 HLA-DQB1 HLA-DRB1
25 limited scleroderma 10.3 HLA-DRB1 IL2
26 discoid lupus erythematosus 10.2 HLA-DRB1 IFNA2
27 rheumatic fever 10.2 HLA-DRB1 IL2
28 paraneoplastic pemphigus 10.2 HLA-DQB1 HLA-DRB1
29 squamous cell carcinoma 10.2
30 brain glioma 10.2 EGFR HLA-DRB1
31 vogt-koyanagi-harada disease 10.2 HLA-DQB1 HLA-DRB1
32 achalasia, familial esophageal 10.2 HLA-DQA1 HLA-DQB1
33 eosinophilia-myalgia syndrome 10.2 HLA-DQA1 HLA-DRB1
34 sympathetic ophthalmia 10.2 HLA-DQA1 HLA-DRB1
35 laryngitis 10.2
36 congenital toxoplasmosis 10.1 HLA-DQA1 HLA-DQB1
37 cervical dystonia 10.1 HLA-DQA1 HLA-DQB1
38 endometritis 10.1 HLA-DQA1 HLA-DQB1
39 exanthem 10.1 EGFR IL2
40 lymphangioma 10.1 EGFR IFNA2
41 aging 10.1
42 bone inflammation disease 10.1 HLA-DRB1 IL2
43 herpes zoster 10.1 IFNA2 IL2
44 cervical squamous cell carcinoma 10.1 EGFR HLA-DRB1
45 rheumatic heart disease 10.1 HLA-DQA1 HLA-DRB1
46 dermatitis herpetiformis 10.1 HLA-DQA1 HLA-DQB1
47 penile cancer 10.1 EGFR IFNA2
48 microscopic colitis 10.0 HLA-DQB1 HLA-DRB1 IL2
49 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1 IL2
50 geographic tongue 10.0 EGFR HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4,Phase 2 113852-37-2 60613
2 Anti-Infective Agents Phase 4,Phase 2
3 Antiviral Agents Phase 4,Phase 3,Phase 2
4 Vaccines Phase 3,Early Phase 1
5 Immunoglobulins Phase 3,Phase 2
6 Antibodies Phase 3,Phase 2
7
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
8
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
9
Pembrolizumab Approved Phase 2 1374853-91-4
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
11 Analgesics Phase 2
12 Cyclooxygenase 2 Inhibitors Phase 2
13 Cyclooxygenase Inhibitors Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Angiogenesis Inhibitors Phase 2,Phase 1
16 Angiogenesis Modulating Agents Phase 2,Phase 1
17 Peripheral Nervous System Agents Phase 2
18 Anti-Inflammatory Agents Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2
20 Antirheumatic Agents Phase 2
21 Retinol palmitate Phase 2
22 Antibodies, Monoclonal Phase 2
23 Pharmaceutical Solutions Phase 2
24 retinol Nutraceutical Phase 2
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
26
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
27 Micronutrients Phase 1
28 Trace Elements Phase 1
29 Vitamins Phase 1
30 Ergocalciferols Phase 1
31 Bone Density Conservation Agents Phase 1
32 Vitamin D2 Nutraceutical Phase 1
33 Calciferol Nutraceutical Phase 1
34
3,3'-diindolylmethane Investigational 1968-05-4
35 Pepsin A
36 Protective Agents

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 Use of Cidofovir for Recurrent Respiratory Papillomatosis Completed NCT00205374 Phase 4 Cidofovir;Placebo
2 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
3 4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3 Propranolol
6 Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2 celebrex (celecoxib);placebo
7 A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2 SGN-00101
8 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis Recruiting NCT02555800 Phase 2 Bevacizumab;Cidofovir
9 Avelumab for People With Recurrent Respiratory Papillomatosis Recruiting NCT02859454 Phase 2 Avelumab
10 Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Recruiting NCT02632344 Phase 2 Pembrolizumab
11 Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP) Completed NCT01020747 Phase 1 Avastin® (bevacizumab);Saline
12 Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP) Not yet recruiting NCT02854761 Phase 1 EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
13 Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease Withdrawn NCT00733252 Phase 1
14 Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP Completed NCT00550914
15 Human Papillomatosis Genotyping of Children in Thailand Completed NCT01304966
16 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
17 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358
18 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Recruiting NCT02592902
19 New Therapy of Laryngeal Papilloma In Children Terminated NCT00591305
20 Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis Withdrawn NCT00829608 Early Phase 1

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

38
Lung, Bone, T Cells, Testes, Trachea, Spinal Cord

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 398)
# Title Authors Year
1
A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program. ( 29136168 )
2018
2
A retrospective case control analysis of the efficacy of Gardasil<sup>Ar</sup>vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx. ( 29380936 )
2018
3
Reply to Fernandez-Bussy et al.: Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968137 )
2018
4
Juvenile-Onset Recurrent Respiratory Papillomatosis: The Benefits of Quadrivalent Human Papillomavirus Vaccination Continue to Accrue. ( 29136167 )
2018
5
Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968150 )
2018
6
Recurrent respiratory papillomatosis with lung and chest wall involvement: A rare complication in an adolescent. ( 28233516 )
2017
7
The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. ( 28940446 )
2017
8
Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature. ( 28992265 )
2017
9
Recurrent respiratory papillomatosis (RRP)-time for a reckoning? ( 28894838 )
2017
10
Therapeutic use of the HPV vaccine in Recurrent Respiratory Papillomatosis: A case report. ( 28109479 )
2017
11
Comparison of cidofovir and the measles, mumps, and rubella vaccine in the treatment of recurrent respiratory papillomatosis. ( 28231366 )
2017
12
PD-L1 expression and CD8+ infiltration shows heterogeneity in juvenile recurrent respiratory papillomatosis. ( 28576522 )
2017
13
Enhanced TH2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP). ( 28860041 )
2017
14
Quality and readability assessment of websites related to recurrent respiratory papillomatosis. ( 28233911 )
2017
15
Human Papillomavirus (HPV) Genotype Distribution in Patients with Recurrent Respiratory Papillomatosis (RRP) in Iran ( 28749631 )
2017
16
HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis. ( 29106857 )
2017
17
Recurrent Respiratory Papillomatosis, more than two entities. ( 29293985 )
2017
18
Recurrent respiratory papillomatosis in a parturient presenting for cesarean delivery. ( 28347573 )
2017
19
Quality of life of young patients with recurrent respiratory papillomatosis. ( 28193306 )
2017
20
Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis-A South African perspective. ( 29054106 )
2017
21
Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey. ( 28657692 )
2017
22
Treatment outcomes of recurrent respiratory papillomatosis : Retrospective analysis of juvenile and adult cases. ( 28840259 )
2017
23
Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases. ( 28757601 )
2017
24
Recurrent respiratory papillomatosis: A state-of-the-art review. ( 28427542 )
2017
25
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity. ( 28805308 )
2017
26
Laryngeal distribution of recurrent respiratory papillomatosis in a previously untreated cohort. ( 28714564 )
2017
27
A case of video-assisted thoracoscopic resection of malignant transformation of pulmonary recurrent respiratory papillomatosis. ( 28523179 )
2017
28
In-office vs. operating room procedures for recurrent respiratory papillomatosis. ( 28489241 )
2017
29
Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. ( 28298239 )
2017
30
Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report. ( 28977096 )
2017
31
Intersurgical interval increased with use of quadrivalent human papillomavirus vaccine (Gardasil) in a pediatric patient with recurrent respiratory papillomatosis: A case report. ( 27863633 )
2016
32
Prevalence and management of Recurrent Respiratory Papillomatosis (RRP) in the UK: cross sectional study. ( 27208548 )
2016
33
Quality of life of patients with recurrent respiratory papillomatosis. ( 27861969 )
2016
34
Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis. ( 26931553 )
2016
35
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis. ( 27600632 )
2016
36
Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity. ( 27658005 )
2016
37
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. ( 26968061 )
2016
38
Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan. ( 26860235 )
2016
39
Is recurrent respiratory papillomatosis a manageable or curable disease? ( 26608928 )
2016
40
Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis. ( 27188508 )
2016
41
Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). ( 27759910 )
2016
42
Impaired T Cell-dependent Humoral Immune Response Associated with Juvenile-onset Recurrent Respiratory Papillomatosis Progression. ( 27821867 )
2016
43
Safety of paediatric day-stay laryngeal surgery for recurrent respiratory papillomatosis. ( 26857327 )
2016
44
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review. ( 27113025 )
2016
45
Response to letter to Editor: "The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors" by Michel R. M. San Giorgi et al. ( 27654254 )
2016
46
Multidimensional vocal assessment after laser treatment for recurrent respiratory papillomatosis. ( 27515839 )
2016
47
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ( 27074766 )
2016
48
Differences in Transcriptional Activity of Human Papillomavirus Type 6 Molecular Variants in Recurrent Respiratory Papillomatosis. ( 26151558 )
2015
49
Nucleotide and phylogenetic analysis of human papillomavirus type 11 isolated from juvenile-onset recurrent respiratory papillomatosis in China. ( 26369639 )
2015
50
Molecular subtypification of human papillomavirus in male adult individuals with recurrent respiratory papillomatosis. ( 25906915 )
2015

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CD274 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
2
Show member pathways
13.43 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
3
Show member pathways
13.2 CD274 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
13.04 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
5
Show member pathways
12.98 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
6
Show member pathways
12.77 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.46 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
8
Show member pathways
12.43 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
9
Show member pathways
12.39 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
10
Show member pathways
12.35 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
11
Show member pathways
12.33 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
12 12.2 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
13
Show member pathways
12.17 HLA-DQA1 HLA-DQB1 HLA-DRB1
14
Show member pathways
12.17 EGFR IFNA2 IL2
15
Show member pathways
12.16 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
16 12.12 HLA-DQA1 HLA-DQB1 HLA-DRB1
17
Show member pathways
12.07 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 11.97 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.96 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
20
Show member pathways
11.91 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.77 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.73 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 11.69 EGFR IFNA2 IL2
24 11.69 HLA-DQA1 HLA-DQB1 HLA-DRB1
25
Show member pathways
11.57 HLA-DQA1 HLA-DQB1 HLA-DRB1
26 11.55 HLA-DQA1 HLA-DQB1 HLA-DRB1
27 11.48 EGFR IL2
28 11.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
29 11.43 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
30 11.42 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1
31 11.37 EGFR IL2
32 11.34 EGFR IL2
33 11.13 HLA-DRB1 IL2
34 11.09 HLA-DRB1 IL2
35
Show member pathways
10.96 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.76 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 trans-Golgi network membrane GO:0032588 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endosome membrane GO:0010008 9.56 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.69 CD274 EGFR IFNA2
2 T cell receptor signaling pathway GO:0050852 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 positive regulation of inflammatory response GO:0050729 9.56 EGFR IL2
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 IFNA2 IL2
6 immune response GO:0006955 9.55 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
7 positive regulation of T cell proliferation GO:0042102 9.54 CD274 IL2
8 interferon-gamma-mediated signaling pathway GO:0060333 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 negative regulation of T cell proliferation GO:0042130 9.52 CD274 HLA-DRB1
10 positive regulation of phosphorylation GO:0042327 9.49 EGFR IFNA2
11 negative regulation of interferon-gamma production GO:0032689 9.48 CD274 HLA-DRB1
12 antigen processing and presentation GO:0019882 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
14 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.32 HLA-DQB1 HLA-DRB1
15 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 T cell costimulation GO:0031295 8.92 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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