AORRP
MCID: RCR004
MIFTS: 45

Recurrent Respiratory Papillomatosis (AORRP) malady

Respiratory diseases category

Summaries for Recurrent Respiratory Papillomatosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards: Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to papilloma and squamous cell carcinoma. An important gene associated with Recurrent Respiratory Papillomatosis is DPM1 (dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit), and among its related pathways are Colorectal Cancer Metastasis and Glioma. The compounds resveratrol and etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Wikipedia:63 Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis,... more...

Aliases & Classifications for Recurrent Respiratory Papillomatosis

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

recurrent respiratory papillomatosis 42 48 60
juvenile-onset recurrent respiratory papillomatosis 42
adult-onset recurrent respiratory papillomatosis 42
juvenile laryngeal papilloma 42
jorrp 42
aorrp 42


External Ids:

MESH via Orphanet35 C535297
UMLS via Orphanet61 C1168198

Related Diseases for Recurrent Respiratory Papillomatosis

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17GeneCards, 18GeneDecks
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Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.8TP53, CDKN1A, CDKN2A
2squamous cell carcinoma30.8UGCG, EGFR, CDKN2A, CDKN1A, TAP1, RAC1
3asthma30.2TAP1, HLA-DQA1, HLA-DRB1
4diabetes mellitus30.2HLA-DQB1, HLA-DRB1, HLA-DQA1, TAP1
5lung cancer30.2EGFR, CDKN2A, CDKN1A, RAC1, PTGS2, ERBB2
6retinoblastoma30.2EGFR, CDKN2A, CDKN1A, RAC1, ERBB2, ESR1
7squamous papillomatosis10.6
8laryngeal papillomatosis10.3
9rubella10.2
10gastroesophageal reflux disease10.2
11measles10.2
12bronchogenic carcinoma10.2
13mumps10.2
14laryngotracheitis10.2
15aspergillosis10.2
16esophagitis10.2
17laryngitis10.2
18lung squamous cell carcinoma10.2
19respiratory failure10.2
20respiratory system disease10.2
21lichen planus10.0IFNA2
22influenza10.0TAP1
23hemangioma10.0IFNA2
24thyroiditis10.0HLA-DRB1
25cervical intraepithelial neoplasia10.0CDKN2A
26hepatitis10.0IFNA2
27ulcerative colitis10.0TP53
28myeloid leukemia10.0CDKN1A
29allergic rhinitis10.0TAP1
30neuroblastoma10.0TP53
31pituitary adenoma10.0RAC1
32tongue cancer10.0CDKN1A
33gallbladder cancer10.0TP53
34malignant mesothelioma10.0CDKN2A
35smooth muscle tumor10.0ESR1
36leprosy10.0HLA-DRB1
37leiomyoma10.0ESR1
38ependymoma10.0EGFR
39pituitary tumors10.0ESR1
40leiomyosarcoma10.0TP53
41urticaria10.0PTGS2
42liver cirrhosis10.0HLA-DRB1, IFNA2
43osteoarthritis10.0PTGS2
44focal epithelial hyperplasia10.0IFNA2
45adenocarcinoma in situ10.0CDKN2A
46angiomyolipoma10.0ESR1
47hepatitis c10.0IFNA2, HLA-DRB1
48psoriasis10.0TAP1, HLA-DRB1
49chondrosarcoma10.0EXT1
50myeloma10.0IFNA2, CDKN1A

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to recurrent respiratory papillomatosis

Clinical Features for Recurrent Respiratory Papillomatosis

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Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Recurrent Respiratory Papillomatosis

Drug clinical trials:

Search ClinicalTrials for Recurrent Respiratory Papillomatosis

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Search CenterWatch for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

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Anatomical Context for Recurrent Respiratory Papillomatosis

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32MalaCards
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MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

32
Lung

Animal Models for Recurrent Respiratory Papillomatosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Recurrent Respiratory Papillomatosis:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.7EXT1
2MP:000538010.5RAC1, ERBB2
3MP:000539010.5HEXB, CDKN1A
4MP:000537510.4HEXB
5MP:000537910.3CDKN2A, CDKN1A, RAC1, TP53
6MP:000363110.3HEXB, HLA-DQB1, CDKN1A, TAP1, ERBB2
7MP:001077110.2TP53, PTGS2, TAP1, CDKN1A, CDKN2A
8MP:000200610.1ERBB2, TAP1, CDKN1A, CDKN2A, EGFR, EXT1
9MP:000537610.0HEXB, HLA-DQB1, UGCG, ESR1
10MP:000536710.0EGFR, HLA-DQB1, HEXB
11MP:000536910.0HEXB, HLA-DQB1, CDKN2A, CDKN1A, RAC1, ESR1
12MP:00053919.8EXT1, HEXB, EGFR
13MP:00053889.7HLA-DQB1, EGFR, CDKN1A, PTGS2, ERBB2, ESR1
14MP:00053899.7HEXB, EGFR, CDKN2A, CDKN1A, RAC1, PTGS2
15MP:00053829.7EXT1, HEXB, EGFR, CDKN1A, RAC1, ERBB2
16MP:00030129.7EXT1, UGCG, EGFR, CDKN2A, CDKN1A, PTGS2
17MP:00053709.7HEXB, HLA-DQB1, EGFR, CDKN2A, CDKN1A, PTGS2
18MP:00053819.6EXT1, HLA-DQB1, EGFR, CDKN2A, CDKN1A, PTGS2
19MP:00053859.4TP53, ESR1, ERBB2, PTGS2, RAC1, CDKN1A
20MP:00053979.4HEXB, HLA-DQB1, HLA-DQA1, EGFR, CDKN2A, CDKN1A
21MP:00053879.4HEXB, HLA-DQB1, HLA-DQA1, EGFR, CDKN2A, CDKN1A
22MP:00053869.3EXT1, HEXB, HLA-DQB1, UGCG, CDKN2A, CDKN1A
23MP:00053849.2EXT1, HEXB, HLA-DQB1, UGCG, EGFR, CDKN2A
24MP:00053789.2EGFR, UGCG, HLA-DQB1, HEXB, EXT1, CDKN2A
25MP:00107689.1EXT1, HEXB, HLA-DQB1, UGCG, EGFR, CDKN2A

Publications for Recurrent Respiratory Papillomatosis

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Genetic Variations for Recurrent Respiratory Papillomatosis

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Expression for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 55SinoBiological, 49PharmGKB, 52R&D Systems
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Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3EGFR
2
Hide members
10.2TP53, CDKN1A
310.2HLA-DQB1, HLA-DQA1, HLA-DRB1
4
Immune response Antigen presentation by MHC class II
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10.2HLA-DQB1, HLA-DQA1, HLA-DRB1
5
Hide members
10.2HLA-DRB1, HLA-DQB1, HLA-DQA1
610.1CDKN2A, RAC1, TP53
710.1TP53, CDKN2A, CDKN1A
8
Transcription P53 signaling pathway
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10.1TP53, CDKN1A, CDKN2A
910.1EGFR, ERBB2, RAC1
10
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10.1IFNA2, HLA-DQA1, HLA-DRB1, HLA-DQB1
1110.1HLA-DRB1, HLA-DQB1, IFNA2, HLA-DQA1
12
Immune response NFAT in immune response
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10.1RAC1, HLA-DQB1, HLA-DQA1, HLA-DRB1
13
Immune response ICOS pathway in T-helper cell
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10.1HLA-DRB1, HLA-DQA1, RAC1, HLA-DQB1
14
Hide members
10.1RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
15
Hide members
10.1HLA-DQA1, RAC1, HLA-DRB1, HLA-DQB1
1610.1HLA-DRB1, HLA-DQB1, HLA-DQA1, RAC1
1710.0TP53, ESR1, PTGS2
1810.0HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR
19
Hide members
10.0HLA-DQB1, HLA-DRB1, HLA-DQA1, PTGS2
2010.0TAP1, CDKN1A, EGFR, TP53
2110.0TP53, CDKN1A, EGFR, IFNA2
22
Hide members
10.0ERBB2, RAC1, CDKN1A, EGFR
2310.0CDKN1A, EGFR, RAC1, ERBB2
2410.0HLA-DQA1, TAP1, HLA-DRB1, RAC1, HLA-DQB1
2510.0TP53, ERBB2, RAC1, EGFR
26
Hide members
9.9TP53, CDKN1A, ERBB2, EGFR
279.9ERBB2, CDKN1A, TP53, EGFR
289.9EGFR, ESR1, TP53, RAC1
299.9TP53, CDKN1A, HLA-DRB1, HLA-DQB1, HLA-DQA1
30
Hide members
9.9PTGS2, HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1
319.9IFNA2, RAC1, CDKN1A, EGFR, TP53
32
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9.9ERBB2, RAC1, CDKN1A, CDKN2A, TP53
339.8EGFR, TP53, RAC1, CDKN1A, CDKN2A
34
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9.8CDKN1A, EGFR, RAC1, ERBB2, TP53
35
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9.8HLA-DRB1, IFNA2, TP53, TAP1, HLA-DQA1, HLA-DQB1
36
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9.8RAC1, ERBB2, CDKN1A, EGFR, ESR1
37
Development Ligand-independent activation of ESR1 and ESR2
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9.8PTGS2, ERBB2, EGFR, RAC1, ESR1
389.8TP53, CDKN1A, CDKN2A, HLA-DQA1, HLA-DQB1, HLA-DRB1
39
Hide members
9.8HLA-DQB1, EGFR, ERBB2, RAC1, HLA-DRB1, HLA-DQA1
40
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9.8RAC1, HLA-DRB1, HLA-DQB1, HLA-DQA1, EGFR, ERBB2
41
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9.7HLA-DRB1, ERBB2, HLA-DQA1, HLA-DQB1, ESR1, TP53
42
Hide members
9.7EGFR, TP53, ERBB2, CDKN2A, CDKN1A, RAC1
43
Hide members
9.7HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR, CDKN1A, TAP1
449.7TP53, ERBB2, RAC1, CDKN1A, EGFR, ESR1
45
Hide members
9.7CDKN1A, RAC1, PTGS2, ERBB2, ESR1, TP53
469.7EGFR, CDKN2A, CDKN1A, PTGS2, ERBB2, TP53
47
Hide members
9.7PTGS2, ERBB2, ESR1, TP53, RAC1, EGFR
48
Hide members
9.6RAC1, EGFR, IFNA2, CDKN1A, TP53, PTGS2
499.6CDKN2A, EGFR, TP53, ERBB2, PTGS2, RAC1
509.5ERBB2, PTGS2, RAC1, TP53, EGFR, CDKN1A

Compounds for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.7ERBB2
2etoposide44 49 59 1113.4ERBB2, UGCG, IFNA2
3acnu4410.4CDKN2A, CDKN1A, TP53
4hrgbeta14410.4ERBB2, CDKN1A, EGFR
5valine4410.4CDKN2A, TAP1, RAC1, ERBB2
6bcnu4410.4TP53, IFNA2, EGFR, CDKN2A
7megestrol acetate4410.4IFNA2, ERBB2, ESR1
8hpvs4410.4TP53, CDKN2A, CDKN1A
9tamoxifen44 49 28 1113.4ERBB2, EGFR, UGCG, CDKN1A
10exemestane49 44 59 1113.3ESR1, ERBB2, EGFR, PTGS2
11temozolomide44 1111.3CDKN1A, TP53, CDKN2A, EGFR, IFNA2
12anastrozole44 1111.3ESR1, ERBB2, EGFR
13suberoylanilide hydroxamic acid4410.3TP53, CDKN1A, EGFR, ERBB2
14irinotecan44 49 1112.3CDKN1A, ERBB2, TP53, CDKN2A, EGFR
15oxaliplatin44 49 1112.3EGFR, CDKN1A, TP53, ERBB2
16taxane4410.2ESR1, CDKN1A, ERBB2, EGFR, TP53
17flavopiridol44 1111.2EGFR, CDKN2A, CDKN1A, ERBB2, TP53
183,3-diindolylmethane4410.2CDKN1A, ESR1, TP53
19n-(4-hydroxyphenyl)retinamide4410.2UGCG, CDKN1A, TP53, ERBB2, ESR1
20lapatinib44 49 1112.2ESR1, HLA-DQA1, EGFR, TAP1, ERBB2, HLA-DRB1
21gefitinib44 49 1112.2PTGS2, ESR1, CDKN1A, EGFR, ERBB2
22gemcitabine44 49 1112.2CDKN1A, PTGS2, TP53, EGFR, ERBB2
23geldanamycin44 49 59 1113.2EGFR, CDKN1A, ERBB2, ESR1, TP53
24celecoxib44 59 28 49 11 2415.2PTGS2, ERBB2, EGFR, CDKN1A
25adriamycin4410.2CDKN1A, UGCG, CDKN2A, ERBB2, TP53
26thymidylate4410.2EGFR, TP53, CDKN2A, ERBB2, CDKN1A, IFNA2
27bortezomib44 1111.2EGFR, CDKN1A, ERBB2, TP53
28carboplatin44 49 1112.1TP53, EGFR, IFNA2, ERBB2
29agar4410.1IFNA2, ERBB2, RAC1, CDKN1A, CDKN2A, EGFR
30mg 13244 5911.1CDKN2A, TP53, ESR1, CDKN1A, EGFR
31docetaxel44 49 59 1113.1CDKN1A, EGFR, ERBB2, ESR1, TP53, CDKN2A
32curcumin4410.1ERBB2, EGFR, CDKN1A, PTGS2, TP53
33tetracycline44 1111.1CDKN2A, RAC1, ERBB2, EGFR
345fluorouracil4410.0ESR1, ERBB2, CDKN1A, CDKN2A, EGFR, IFNA2
35hydroxyurea44 49 1112.0TP53, CDKN1A, CDKN2A, IFNA2
36toremifene44 1111.0ESR1, ERBB2, IFNA2
37n acetylcysteine4410.0CDKN2A, EGFR, ERBB2, CDKN1A, PTGS2, TP53
38paraffin4410.0ESR1, TP53, ERBB2, CDKN1A, CDKN2A, HLA-DQA1
39ly294002449.9PTGS2, ERBB2, RAC1, CDKN1A, EGFR, TP53
40oligonucleotide449.9CDKN1A, CDKN2A, TAP1, RAC1, HLA-DQB1, HLA-DRB1
41genistein44 28 59 2 11 2414.9RAC1, CDKN1A, PTGS2, EGFR, ERBB2, ESR1
42retinoid449.9EGFR, CDKN1A, TP53, ESR1, IFNA2
43progesterone44 59 28 11 2413.9IFNA2, EGFR, CDKN2A, CDKN1A, ESR1, ERBB2
44doxorubicin44 49 1111.9ESR1, CDKN1A, CDKN2A, EGFR, UGCG, IFNA2
45paclitaxel44 49 1111.9CDKN2A, EGFR, UGCG, CDKN1A, RAC1, ERBB2
46olomoucine44 1110.8CDKN1A, TP53, CDKN2A
47cisplatin44 49 59 1112.8RAC1, CDKN1A, EGFR, TP53, PTGS2, CDKN2A
48vegf449.7PTGS2, RAC1, CDKN1A, IFNA2, EGFR, CDKN2A
49retinoic acid44 2410.7IFNA2, UGCG, RAC1, CDKN1A, ESR1, EGFR
50arginine449.6HLA-DQA1, HLA-DRB1, CDKN2A, RAC1, EXT1, ERBB2

GO Terms for genes affiliated with Recurrent Respiratory Papillomatosis

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Sources:
16Gene Ontology
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Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.4HLA-DQB1, HLA-DRB1, HLA-DQA1
2clathrin-coated endocytic vesicle membraneGO:03066910.3HLA-DQB1, HLA-DRB1, HLA-DQA1
3integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-DQA1, HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:03065810.2HLA-DQB1, HLA-DRB1, HLA-DQA1
5ER to Golgi transport vesicle membraneGO:01250710.2HLA-DQB1, HLA-DRB1, HLA-DQA1
6endocytic vesicle membraneGO:03066610.2HLA-DQA1, HLA-DRB1, HLA-DQB1
7trans-Golgi network membraneGO:03258810.1HLA-DQB1, HLA-DRB1, HLA-DQA1
8membraneGO:0160209.8ESR1, DPM1, EGFR, UGCG, HLA-DRB1, HLA-DQB1
9endosome membraneGO:0100089.7ERBB2, EGFR, HLA-DQA1, HLA-DQB1
10Golgi membraneGO:0001399.6FUT8, HS3ST3A1, EXT1, HLA-DQB1, HLA-DRB1, HLA-DQA1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DQB1, HLA-DRB1
2negative regulation of immature T cell proliferation in thymusGO:03308810.5CDKN2A, ERBB2
3humoral immune response mediated by circulating immunoglobulinGO:00245510.4HLA-DRB1, HLA-DQB1
4interferon-gamma-mediated signaling pathwayGO:06033310.4HLA-DQB1, HLA-DRB1, HLA-DQA1
5T cell costimulationGO:03129510.4RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
6positive regulation of fibroblast proliferationGO:04814610.3ESR1, CDKN1A, EGFR
7positive regulation of nitric oxide biosynthetic processGO:04542910.3EGFR, PTGS2, ESR1
8mitotic cell cycle arrestGO:07185010.3TP53, CDKN1A
9cytokine-mediated signaling pathwayGO:01922110.3HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNA2
10negative regulation of gene expressionGO:01062910.3ESR1, CDKN1A, IFNA2
11Fc-epsilon receptor signaling pathwayGO:03809510.2ERBB2, RAC1, CDKN1A, EGFR
12replicative senescenceGO:09039910.2CDKN2A, TP53
13Ras protein signal transductionGO:00726510.2CDKN2A, CDKN1A, TP53
14antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.2HLA-DQA1, HLA-DRB1, HLA-DQB1
15T cell receptor signaling pathwayGO:05085210.1HLA-DQA1, HLA-DRB1, HLA-DQB1
16neurotrophin TRK receptor signaling pathwayGO:0480119.7EGFR, CDKN1A, RAC1, ERBB2

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.3HLA-DQA1, HLA-DRB1, HLA-DQB1
2epidermal growth factor-activated receptor activityGO:00500610.3ERBB2, EGFR
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1A, CDKN2A
4MDM2/MDM4 family protein bindingGO:09737110.2TP53, CDKN2A
5nitric-oxide synthase regulator activityGO:03023510.1EGFR, ESR1
6enzyme bindingGO:0198999.9EGFR, RAC1, PTGS2, ESR1, TP53
7protein heterodimerization activityGO:0469829.9EXT1, HEXB, EGFR, ERBB2, TP53
8receptor signaling protein tyrosine kinase activityGO:0047169.9ERBB2, EGFR

Products for genes affiliated with Recurrent Respiratory Papillomatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Recurrent Respiratory Papillomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet