MCID: RCR004
MIFTS: 41

Recurrent Respiratory Papillomatosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

MalaCards integrated aliases for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 50 56 69
Juvenile-Onset Recurrent Respiratory Papillomatosis 50
Adult-Onset Recurrent Respiratory Papillomatosis 50
Respiratory Papillomatosis, Recurrent 50
Laryngeal Papilloma, Recurrent 50
Juvenile Laryngeal Papilloma 50
Aorrp 50
Jorrp 50
Rrp 50

Characteristics:

Orphanet epidemiological data:

56
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 56  
Rare respiratory diseases


External Ids:

Orphanet 56 ORPHA60032
MESH via Orphanet 43 C535297
UMLS via Orphanet 70 C1168198

Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 50 recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to laryngeal papillomatosis and fruit allergy. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Cidofovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and t cells.

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 laryngeal papillomatosis 11.1
2 fruit allergy 10.5 HLA-DQB1 HLA-DRB1
3 breast hemangiopericytoma 10.5 HLA-DQB1 HLA-DRB1
4 biemond syndrome 10.5 HLA-DQB1 HLA-DRB1
5 light chain deposition disease 10.5 HLA-DQB1 HLA-DRB1
6 juvenile sialidosis type 2 10.5 HLA-DQB1 HLA-DRB1
7 idiopathic subglottic tracheal stenosis 10.5 HLA-DQB1 HLA-DRB1
8 mosaic trisomy 1 10.5 HLA-DQB1 HLA-DRB1
9 autoimmune retinopathy 10.5 HLA-DQB1 HLA-DRB1
10 progressive myoclonus epilepsy 10.5 HLA-DQB1 HLA-DRB1
11 limb-body wall complex 10.5 HLA-DQB1 HLA-DRB1
12 transient retinal arterial occlusion 10.5 HLA-DQB1 HLA-DRB1
13 ovarian surface papilloma 10.5 HLA-DQB1 HLA-DRB1
14 pellagra like syndrome 10.4 HLA-DQB1 HLA-DRB1
15 clear cell adenocarcinoma of ovary 10.4 HLA-DQB1 HLA-DRB1
16 anthracosilicosis 10.4 HLA-DRB1 IL2
17 mazabraud syndrome 10.4 HLA-DQB1 HLA-DRB1
18 papillary squamous carcinoma 10.4 HLA-DQB1 HLA-DRB1
19 reproductive system disease 10.4 HLA-DQB1 HLA-DRB1
20 oculogyric crisis 10.4 HLA-DQB1 HLA-DRB1
21 cryptococcosis 10.4 HLA-DQB1 HLA-DRB1
22 cerebral sarcoidosis 10.4 HLA-DRB1 IL2
23 infantile hypotonia 10.4 HLA-DQB1 HLA-DRB1
24 moderately severe hemophilia b 10.3 HLA-DQB1 HLA-DRB1
25 diffuse scleroderma 10.3 HLA-DRB1 IL2
26 epidermolysis bullosa simplex superficialis 10.3 HLA-DQB1 HLA-DRB1
27 endogenous depression 10.3 HLA-DRB1 IL2
28 classic hairy cell leukemia 10.2 HLA-DQB1 HLA-DRB1
29 aids wasting syndrome 10.2 HLA-DRB1 IFNA2
30 papilloma 10.2
31 squamous cell carcinoma 10.1
32 left bundle branch hemiblock 10.1 HLA-DRB1 IL2
33 early congenital syphilis 10.1 EGFR IL2
34 laryngitis 10.1
35 lymphocytic colitis 10.1 HLA-DQB1 HLA-DRB1 IL2
36 childhood type dermatomyositis 10.0 EGFR HLA-DRB1
37 advanced sleep phase syndrome, familial, 1 10.0 HLA-DQB1 HLA-DRB1 IL2
38 anaerobic meningitis 10.0 EGFR HLA-DQB1 HLA-DRB1
39 sezary's disease 10.0 IFNA2 IL2
40 myxedema 10.0 EGFR IFNA2
41 mesenchymal cell neoplasm 9.9 HLA-DRB1 IL2
42 gastroesophageal reflux 9.9
43 mumps 9.9
44 measles 9.9
45 rubella 9.9
46 anterior corneal pigmentation 9.9 HLA-DQB1 HLA-DRB1 IFNA2
47 epidermodysplasia verruciformis 9.8
48 hemoglobin c disease 9.8 IFNA2 IL2
49 acral lentiginous melanoma 9.8 IFNA2 IL2
50 bartter disease 9.8 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4,Phase 2 113852-37-2 60613
2 Anti-Infective Agents Phase 4,Phase 2
3 Antiviral Agents Phase 4,Phase 3,Phase 2
4 Vaccines Phase 3,Early Phase 1
5 Antibodies Phase 3,Phase 2
6 Immunoglobulins Phase 3,Phase 2
7
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
8
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
9
Pembrolizumab Approved Phase 2 1374853-91-4
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
11 Analgesics Phase 2
12 Analgesics, Non-Narcotic Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Anti-Inflammatory Agents, Non-Steroidal Phase 2
15 Antirheumatic Agents Phase 2
16 Cyclooxygenase 2 Inhibitors Phase 2
17 Cyclooxygenase Inhibitors Phase 2
18 Peripheral Nervous System Agents Phase 2
19 Angiogenesis Inhibitors Phase 2,Phase 1
20 Angiogenesis Modulating Agents Phase 2,Phase 1
21 Pharmaceutical Solutions Phase 2
22 Retinol palmitate Phase 2
23 Antibodies, Monoclonal Phase 2
24 retinol Nutraceutical Phase 2
25
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
27 Bone Density Conservation Agents Phase 1
28 Ergocalciferols Phase 1
29 Micronutrients Phase 1
30 Trace Elements Phase 1
31 Vitamins Phase 1
32 Calciferol Nutraceutical Phase 1
33 Vitamin D2 Nutraceutical Phase 1
34 Pepsin A

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 Use of Cidofovir for Recurrent Respiratory Papillomatosis Completed NCT00205374 Phase 4 Cidofovir;Placebo
2 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
3 4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3 Propranolol
6 Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2 celebrex (celecoxib);placebo
7 A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2 SGN-00101
8 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis Recruiting NCT02555800 Phase 2 Bevacizumab;Cidofovir
9 Avelumab for People With Recurrent Respiratory Papillomatosis Recruiting NCT02859454 Phase 2 Avelumab
10 Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Recruiting NCT02632344 Phase 2 Pembrolizumab
11 Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP) Completed NCT01020747 Phase 1 Avastin® (bevacizumab);Saline
12 Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP) Not yet recruiting NCT02854761 Phase 1 EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
13 Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease Withdrawn NCT00733252 Phase 1
14 Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP Completed NCT00550914
15 Human Papillomatosis Genotyping of Children in Thailand Completed NCT01304966
16 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
17 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358
18 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Recruiting NCT02592902
19 New Therapy of Laryngeal Papilloma In Children Terminated NCT00591305
20 Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis Withdrawn NCT00829608 Early Phase 1

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

39
Lung, Bone, T Cells, Testes, Trachea, Spinal Cord

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 388)
id Title Authors Year
1
Comparison of cidofovir and the measles, mumps, and rubella vaccine in the treatment of recurrent respiratory papillomatosis. ( 28231366 )
2017
2
Human Papillomavirus (HPV) Genotype Distribution in Patients with Recurrent Respiratory Papillomatosis (RRP) in Iran ( 28749631 )
2017
3
Therapeutic use of the HPV vaccine in Recurrent Respiratory Papillomatosis: A case report. ( 28109479 )
2017
4
PD-L1 expression and CD8+ infiltration shows heterogeneity in juvenile recurrent respiratory papillomatosis. ( 28576522 )
2017
5
Laryngeal distribution of recurrent respiratory papillomatosis in a previously untreated cohort. ( 28714564 )
2017
6
Enhanced TH2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP). ( 28860041 )
2017
7
Recurrent respiratory papillomatosis: A state-of-the-art review. ( 28427542 )
2017
8
Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases. ( 28757601 )
2017
9
A case of video-assisted thoracoscopic resection of malignant transformation of pulmonary recurrent respiratory papillomatosis. ( 28523179 )
2017
10
Quality of life of young patients with recurrent respiratory papillomatosis. ( 28193306 )
2017
11
Treatment outcomes of recurrent respiratory papillomatosis : Retrospective analysis of juvenile and adult cases. ( 28840259 )
2017
12
Quality and readability assessment of websites related to recurrent respiratory papillomatosis. ( 28233911 )
2017
13
Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. ( 28298239 )
2017
14
Recurrent respiratory papillomatosis in a parturient presenting for cesarean delivery. ( 28347573 )
2017
15
The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. ( 28940446 )
2017
16
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity. ( 28805308 )
2017
17
Recurrent respiratory papillomatosis (RRP)-time for a reckoning? ( 28894838 )
2017
18
In-office vs. operating room procedures for recurrent respiratory papillomatosis. ( 28489241 )
2017
19
Recurrent respiratory papillomatosis with lung and chest wall involvement: A rare complication in an adolescent. ( 28233516 )
2017
20
Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey. ( 28657692 )
2017
21
Is recurrent respiratory papillomatosis a manageable or curable disease? ( 26608928 )
2016
22
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ( 27074766 )
2016
23
Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis. ( 26931553 )
2016
24
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review. ( 27113025 )
2016
25
Safety of paediatric day-stay laryngeal surgery for recurrent respiratory papillomatosis. ( 26857327 )
2016
26
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis. ( 27600632 )
2016
27
Response to letter to Editor: "The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors" by Michel R. M. San Giorgi et al. ( 27654254 )
2016
28
Intersurgical interval increased with use of quadrivalent human papillomavirus vaccine (Gardasil) in a pediatric patient with recurrent respiratory papillomatosis: A case report. ( 27863633 )
2016
29
Impaired T Cell-dependent Humoral Immune Response Associated with Juvenile-onset Recurrent Respiratory Papillomatosis Progression. ( 27821867 )
2016
30
Multidimensional vocal assessment after laser treatment for recurrent respiratory papillomatosis. ( 27515839 )
2016
31
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. ( 26968061 )
2016
32
Quality of life of patients with recurrent respiratory papillomatosis. ( 27861969 )
2016
33
Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan. ( 26860235 )
2016
34
Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity. ( 27658005 )
2016
35
Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). ( 27759910 )
2016
36
Prevalence and management of Recurrent Respiratory Papillomatosis (RRP) in the UK: cross sectional study. ( 27208548 )
2016
37
Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis. ( 27188508 )
2016
38
Acoustical and Perceptual Voice Profiling of Children With Recurrent Respiratory Papillomatosis. ( 26474713 )
2015
39
Recurrent respiratory papillomatosis in northern Sweden: clinical characteristics and practical guidance. ( 26004132 )
2015
40
Risk Factors for Dysplasia in Recurrent Respiratory Papillomatosis in an Adult and Pediatric Population. ( 26453486 )
2015
41
Differences in Transcriptional Activity of Human Papillomavirus Type 6 Molecular Variants in Recurrent Respiratory Papillomatosis. ( 26151558 )
2015
42
Molecular subtypification of human papillomavirus in male adult individuals with recurrent respiratory papillomatosis. ( 25906915 )
2015
43
Nucleotide and phylogenetic analysis of human papillomavirus type 11 isolated from juvenile-onset recurrent respiratory papillomatosis in China. ( 26369639 )
2015
44
Recurrent respiratory papillomatosis: current and future perspectives. ( 25999724 )
2015
45
FDG PET/CT Findings of Recurrent Respiratory Papillomatosis With Malignant Degeneration in the Lung. ( 26204210 )
2015
46
Viral load and mRNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis. ( 26010342 )
2015
47
Recurrent respiratory papillomatosis progressing into squamous cell carcinoma in an HIV-positive patient. ( 26153613 )
2015
48
Recurrent respiratory papillomatosis of the airway: The experience of an endoscopic unit. ( 25926371 )
2015
49
Age of onset of Recurrent Respiratory Papillomatosis: a distribution analysis. ( 26460806 )
2015
50
Rapid response to systemic bevacizumab therapy in recurrent respiratory papillomatosis. ( 25289079 )
2014

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 EGFR HLA-DQB1 HLA-DRB1 IFNA2 IL2 KIR2DL2
2
Show member pathways
12.87 EGFR HLA-DQB1 HLA-DRB1 IL2
3
Show member pathways
12.83 EGFR HLA-DQB1 HLA-DRB1 IFNA2 IL2
4
Show member pathways
12.33 HLA-DQB1 HLA-DRB1 IL2
5
Show member pathways
12.27 HLA-DQB1 HLA-DRB1 IL2
6
Show member pathways
12.19 HLA-DQB1 HLA-DRB1 IFNA2
7
Show member pathways
12.16 IFNA2 IL2 KIR2DL2
8 12.06 HLA-DQB1 HLA-DRB1 IL2
9
Show member pathways
12.01 HLA-DQB1 HLA-DRB1 IL2
10
Show member pathways
11.95 HLA-DQB1 HLA-DRB1 IFNA2 IL2
11 11.8 HLA-DQB1 HLA-DRB1 IFNA2
12
Show member pathways
11.76 HLA-DQB1 HLA-DRB1 IFNA2 IL2 KIR2DL2
13 11.49 IFNA2 IL2
14 11.46 HLA-DQB1 HLA-DRB1
15
Show member pathways
11.45 HLA-DQB1 HLA-DRB1
16 11.41 EGFR IL2
17 11.41 EGFR HLA-DQB1 HLA-DRB1
18 11.32 HLA-DQB1 HLA-DRB1
19 11.28 EGFR IFNA2 IL2
20 11.26 EGFR IL2
21 11.22 EGFR IL2
22 10.91 HLA-DRB1 IL2
23 10.85 HLA-DRB1 IL2

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.43 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.37 HLA-DQB1 HLA-DRB1
4 endosome membrane GO:0010008 9.33 EGFR HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DQB1 HLA-DRB1
7 Golgi membrane GO:0000139 9.26 EGFR FUT8 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQB1 HLA-DRB1
2 positive regulation of inflammatory response GO:0050729 9.4 EGFR IL2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 IFNA2 IL2
4 antigen processing and presentation GO:0019882 9.32 HLA-DQB1 HLA-DRB1
5 positive regulation of phosphorylation GO:0042327 9.26 EGFR IFNA2
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 virus receptor activity GO:0001618 8.85 HLA-DRB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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