Recurrent Respiratory Papillomatosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

AORRP MCID: RCR004 MIFTS: 45	Recurrent Respiratory Papillomatosis (AORRP) malady Respiratory diseases category
42 genes, 1 tissue, 153 related diseases, clinical trials.

Summaries for Recurrent Respiratory Papillomatosis

Sources:
⁴²NIH Rare Diseases, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Recurrent respiratory papillomatosis (rrp) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. the tumors may vary in size and grow very quickly. they often grow back even when removed. rrp is caused by two types of human papillomavirus (hpv), called hpv 6 and hpv 11. last updated: 11/21/2011

MalaCards: Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to papilloma and squamous cell carcinoma. An important gene associated with Recurrent Respiratory Papillomatosis is DPM1 (dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit), and among its related pathways are Colorectal Cancer Metastasis and Glioma. The compounds resveratrol and etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Wikipedia:⁶³ Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis,... more...

Aliases & Classifications for Recurrent Respiratory Papillomatosis

Sources:
⁴²NIH Rare Diseases, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁵MESH via Orphanet, ⁶¹UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases

Aliases & Descriptions:

recurrent respiratory papillomatosis ⁴² ⁴⁸ ⁶⁰

juvenile-onset recurrent respiratory papillomatosis ⁴²

adult-onset recurrent respiratory papillomatosis ⁴²

juvenile laryngeal papilloma ⁴²

jorrp ⁴²

aorrp ⁴²

External Ids:

MESH via Orphanet³⁵ C535297

UMLS via Orphanet⁶¹ C1168198

Related Diseases for Recurrent Respiratory Papillomatosis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 153)

id	Related Disease	Score	Top Affiliating Genes
1	papilloma	30.8	TP53, CDKN1A, CDKN2A
2	squamous cell carcinoma	30.8	UGCG, EGFR, CDKN2A, CDKN1A, TAP1, RAC1
3	asthma	30.2	TAP1, HLA-DQA1, HLA-DRB1
4	diabetes mellitus	30.2	HLA-DQB1, HLA-DRB1, HLA-DQA1, TAP1
5	lung cancer	30.2	EGFR, CDKN2A, CDKN1A, RAC1, PTGS2, ERBB2
6	retinoblastoma	30.2	EGFR, CDKN2A, CDKN1A, RAC1, ERBB2, ESR1
7	squamous papillomatosis	10.6
8	laryngeal papillomatosis	10.3
9	rubella	10.2
10	gastroesophageal reflux disease	10.2
11	measles	10.2
12	bronchogenic carcinoma	10.2
13	mumps	10.2
14	laryngotracheitis	10.2
15	aspergillosis	10.2
16	esophagitis	10.2
17	laryngitis	10.2
18	lung squamous cell carcinoma	10.2
19	respiratory failure	10.2
20	respiratory system disease	10.2
21	lichen planus	10.0	IFNA2
22	influenza	10.0	TAP1
23	hemangioma	10.0	IFNA2
24	thyroiditis	10.0	HLA-DRB1
25	cervical intraepithelial neoplasia	10.0	CDKN2A
26	hepatitis	10.0	IFNA2
27	ulcerative colitis	10.0	TP53
28	myeloid leukemia	10.0	CDKN1A
29	allergic rhinitis	10.0	TAP1
30	neuroblastoma	10.0	TP53
31	pituitary adenoma	10.0	RAC1
32	tongue cancer	10.0	CDKN1A
33	gallbladder cancer	10.0	TP53
34	malignant mesothelioma	10.0	CDKN2A
35	smooth muscle tumor	10.0	ESR1
36	leprosy	10.0	HLA-DRB1
37	leiomyoma	10.0	ESR1
38	ependymoma	10.0	EGFR
39	pituitary tumors	10.0	ESR1
40	leiomyosarcoma	10.0	TP53
41	urticaria	10.0	PTGS2
42	liver cirrhosis	10.0	HLA-DRB1, IFNA2
43	osteoarthritis	10.0	PTGS2
44	focal epithelial hyperplasia	10.0	IFNA2
45	adenocarcinoma in situ	10.0	CDKN2A
46	angiomyolipoma	10.0	ESR1
47	hepatitis c	10.0	IFNA2, HLA-DRB1
48	psoriasis	10.0	TAP1, HLA-DRB1
49	chondrosarcoma	10.0	EXT1
50	myeloma	10.0	IFNA2, CDKN1A

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:

Clinical Features for Recurrent Respiratory Papillomatosis

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Search CenterWatch for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

Sources:
³²MalaCards
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MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

³²

Lung

Animal Models for Recurrent Respiratory Papillomatosis or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Recurrent Respiratory Papillomatosis:

³⁶ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	10.7	EXT1
2	embryogenesis phenotype	MP:0005380	10.5	RAC1, ERBB2
3	skeleton phenotype	MP:0005390	10.5	HEXB, CDKN1A
4	adipose tissue phenotype	MP:0005375	10.4	HEXB
5	endocrine/exocrine gland phenotype	MP:0005379	10.3	CDKN2A, CDKN1A, RAC1, TP53
6	nervous system phenotype	MP:0003631	10.3	HEXB, HLA-DQB1, CDKN1A, TAP1, ERBB2
7	integument phenotype	MP:0010771	10.2	TP53, PTGS2, TAP1, CDKN1A, CDKN2A
8	tumorigenesis	MP:0002006	10.1	ERBB2, TAP1, CDKN1A, CDKN2A, EGFR, EXT1
9	homeostasis/metabolism phenotype	MP:0005376	10.0	HEXB, HLA-DQB1, UGCG, ESR1
10	renal/urinary system phenotype	MP:0005367	10.0	EGFR, HLA-DQB1, HEXB
11	muscle phenotype	MP:0005369	10.0	HEXB, HLA-DQB1, CDKN2A, CDKN1A, RAC1, ESR1
12	vision/eye phenotype	MP:0005391	9.8	EXT1, HEXB, EGFR
13	respiratory system phenotype	MP:0005388	9.7	HLA-DQB1, EGFR, CDKN1A, PTGS2, ERBB2, ESR1
14	reproductive system phenotype	MP:0005389	9.7	HEXB, EGFR, CDKN2A, CDKN1A, RAC1, PTGS2
15	craniofacial phenotype	MP:0005382	9.7	EXT1, HEXB, EGFR, CDKN1A, RAC1, ERBB2
16	no phenotypic analysis	MP:0003012	9.7	EXT1, UGCG, EGFR, CDKN2A, CDKN1A, PTGS2
17	liver/biliary system phenotype	MP:0005370	9.7	HEXB, HLA-DQB1, EGFR, CDKN2A, CDKN1A, PTGS2
18	digestive/alimentary phenotype	MP:0005381	9.6	EXT1, HLA-DQB1, EGFR, CDKN2A, CDKN1A, PTGS2
19	cardiovascular system phenotype	MP:0005385	9.4	TP53, ESR1, ERBB2, PTGS2, RAC1, CDKN1A
20	hematopoietic system phenotype	MP:0005397	9.4	HEXB, HLA-DQB1, HLA-DQA1, EGFR, CDKN2A, CDKN1A
21	immune system phenotype	MP:0005387	9.4	HEXB, HLA-DQB1, HLA-DQA1, EGFR, CDKN2A, CDKN1A
22	behavior/neurological phenotype	MP:0005386	9.3	EXT1, HEXB, HLA-DQB1, UGCG, CDKN2A, CDKN1A
23	cellular phenotype	MP:0005384	9.2	EXT1, HEXB, HLA-DQB1, UGCG, EGFR, CDKN2A
24	growth/size phenotype	MP:0005378	9.2	EGFR, UGCG, HLA-DQB1, HEXB, EXT1, CDKN2A
25	mortality/aging	MP:0010768	9.1	EXT1, HEXB, HLA-DQB1, UGCG, EGFR, CDKN2A

Publications for Recurrent Respiratory Papillomatosis

Genes related to Recurrent Respiratory Papillomatosis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Recurrent Respiratory Papillomatosis:

(show all 42)

id	Symbol	Description	Score	Implication
1	DPM1	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	20.25	GeneCards inferred : Publications, Disorders (show sections)
2	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	19.77	GeneCards inferred : Publications, Disorders (show sections)
3	HEXB	hexosaminidase B (beta polypeptide)	19.30	GeneCards inferred : Publications, Disorders (show sections)
4	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	18.82	GeneCards inferred : Publications, Disorders (show sections)
5	IFNA2	interferon, alpha 2	18.35	GeneCards inferred : Publications, Disorders (show sections)
6	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	17.87	GeneCards inferred : Publications, Disorders (show sections)
7	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	17.39	GeneCards inferred : Publications, Disorders (show sections)
8	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	16.92	GeneCards inferred : Publications, Disorders (show sections)
9	FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	16.44	GeneCards inferred : Publications, Disorders (show sections)
10	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	15.96	GeneCards inferred : Publications, Disorders (show sections)
11	CDKN2A	cyclin-dependent kinase inhibitor 2A	15.49	GeneCards inferred : Publications, Disorders (show sections)
12	EXT1	exostosin glycosyltransferase 1	15.01	GeneCards inferred : Publications, Disorders (show sections)
13	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	14.54	GeneCards inferred : Publications, Disorders (show sections)
14	TP53	tumor protein p53	14.06	GeneCards inferred : Publications, Disorders (show sections)
15	EGFR	epidermal growth factor receptor	13.58	GeneCards inferred : Publications, Disorders (show sections)
16	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	13.11	GeneCards inferred : Publications, Disorders (show sections)
17	ESR1	estrogen receptor 1	12.63	GeneCards inferred : Publications, Disorders (show sections)
18	UGCG	UDP-glucose ceramide glucosyltransferase	12.16	GeneCards inferred : Publications, Disorders (show sections)
19	RPL32	ribosomal protein L32	11.68	GeneCards inferred : Publications, Disorders (show sections)
20	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	11.20	GeneCards inferred : Publications, Disorders (show sections)
21	KIR3DP1	killer cell immunoglobulin-like receptor, three domains, pseudogene 1	10.51	GeneCards inferred : Publications (show sections)
22	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	10.04	GeneCards inferred : Publications (show sections)
23	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	9.55	GeneCards inferred : Publications (show sections)
24	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	9.08	GeneCards inferred : Publications (show sections)
25	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	8.60	GeneCards inferred : Publications (show sections)
26	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	8.12	GeneCards inferred : Publications (show sections)
27	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	7.65	GeneCards inferred : Publications (show sections)
28	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	7.17	GeneCards inferred : Publications (show sections)
29	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	6.69	GeneCards inferred : Publications (show sections)
30	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	6.22	GeneCards inferred : Publications (show sections)
31	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	5.74	GeneCards inferred : Publications (show sections)
32	KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	5.26	GeneCards inferred : Publications (show sections)
33	KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	4.78	GeneCards inferred : Publications (show sections)
34	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	4.30	GeneCards inferred : Publications (show sections)
35	KIR2DS4	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4	3.82	GeneCards inferred : Publications (show sections)
36	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	3.34	GeneCards inferred : Publications (show sections)
37	STAT5A	signal transducer and activator of transcription 5A	2.86	GeneCards inferred : Publications (show sections)
38	HLA-A	major histocompatibility complex, class I, A	2.36	GeneCards inferred : Publications (show sections)
39	HLA-C	major histocompatibility complex, class I, C	1.89	GeneCards inferred : Publications (show sections)
40	IL2	interleukin 2	1.41	GeneCards inferred : Publications (show sections)
41	HLA-B	major histocompatibility complex, class I, B	0.93	GeneCards inferred : Publications (show sections)
42	IFNG	interferon, gamma	0.45	GeneCards inferred : Publications (show sections)

Products for genes related to Recurrent Respiratory Papillomatosis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	38	38	34
2	LSBio	-	-	42

Genetic Variations for Recurrent Respiratory Papillomatosis

Expression for genes affiliated with Recurrent Respiratory Papillomatosis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for genes affiliated with Recurrent Respiratory Papillomatosis

Sources:
⁵¹QIAGEN, ²⁹KEGG, ³⁷NCBI BioSystems Database, ¹²EMD Millipore, ⁵³Reactome, ⁵⁵SinoBiological, ⁴⁹PharmGKB, ⁵²R&D Systems
See all sources

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50) (show all 60)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Colorectal Cancer Metastasis⁵¹	10.3	EGFR
2	Glioma²⁹ Hide members Non-small cell lung cancer²⁹ Prostate cancer²⁹ Melanoma²⁹ Bladder cancer²⁹ Signaling Pathways in Glioblastoma³⁷	10.2	TP53, CDKN1A
3	Staphylococcus aureus infection²⁹	10.2	HLA-DQA1, HLA-DRB1, HLA-DQB1
4	Immune response Antigen presentation by MHC class II Hide members Immune response Antigen presentation by MHC class II¹²	10.2	HLA-DQA1, HLA-DRB1, HLA-DQB1
5	Translocation of ZAP-70 to Immunological synapse⁵³ Hide members Generation of second messenger molecules⁵³ PD-1 signaling⁵³ Phosphorylation of CD3 and TCR zeta chains⁵³	10.2	HLA-DQA1, HLA-DRB1, HLA-DQB1
6	Inhibition of Ribosome Biogenesis by p14(ARF)⁵¹	10.1	CDKN2A, RAC1, TP53
7	TP53 network³⁷	10.1	CDKN2A, CDKN1A, TP53
8	Transcription P53 signaling pathway Hide members Transcription P53 signaling pathway¹²	10.1	CDKN2A, CDKN1A, TP53
9	Agrin Interactions at Neuromuscular Junction⁵¹	10.1	ERBB2, RAC1, EGFR
10	Allograft rejection²⁹ Hide members Autoimmune thyroid disease²⁹ Viral myocarditis²⁹ Intestinal immune network for IgA production²⁹ Asthma²⁹ Type I diabetes mellitus²⁹ Graft-versus-host disease²⁹ CTL Mediated Apoptosis⁵¹ Antigen processing and presentation²⁹ THC Differentiation Pathway⁵¹	10.1	IFNA2, HLA-DQB1, HLA-DRB1, HLA-DQA1
11	Tuberculosis²⁹	10.1	IFNA2, HLA-DQB1, HLA-DRB1, HLA-DQA1
12	CD28 co-stimulation⁵³ Hide members CD28 dependent Vav1 pathway⁵³ Costimulation by the CD28 family⁵³ CTLA4 Signaling⁵¹	10.1	RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
13	Immune response T cell receptor signaling pathway¹²	10.1	RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
14	ICos-ICosL Pathway in T-Helper Cell⁵¹ Hide members CD28 Signaling in T-Helper Cell⁵¹ Calcium Mediated T-Cell Apoptosis⁵¹	10.1	HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1
15	Immune response ICOS pathway in T-helper cell Hide members Immune response ICOS pathway in T-helper cell¹²	10.1	HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1
16	Immune response NFAT in immune response Hide members Immune response NFAT in immune response¹²	10.1	HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1
17	Signaling mediated by p38-alpha and p38-beta³⁷	10.0	PTGS2, ESR1, TP53
18	G-protein signaling N-RAS regulation pathway¹²	10.0	EGFR, HLA-DQA1, HLA-DRB1, HLA-DQB1
19	Leishmaniasis²⁹ Hide members Toxoplasmosis²⁹ Inflammatory bowel disease (IBD)²⁹	10.0	PTGS2, HLA-DQA1, HLA-DRB1, HLA-DQB1
20	Direct p53 effectors³⁷	10.0	EGFR, CDKN1A, TAP1, TP53
21	Hepatitis C²⁹	10.0	IFNA2, EGFR, CDKN1A, TP53
22	Fc epsilon receptor (FCERI) signaling⁵³ Hide members Role of LAT2/NTAL/LAB on calcium mobilization⁵³	10.0	ERBB2, RAC1, CDKN1A, EGFR
23	Alpha6-Beta4 Integrin Signaling Pathway³⁷	10.0	EGFR, CDKN1A, RAC1, ERBB2
24	Phagosome²⁹	10.0	HLA-DQB1, HLA-DRB1, HLA-DQA1, TAP1, RAC1
25	EGFR Signaling Pathway⁵⁵	10.0	TP53, ERBB2, RAC1, EGFR
26	ErbB signaling pathway²⁹ Hide members ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁴⁹	9.9	TP53, ERBB2, CDKN1A, EGFR
27	Akt Signaling Pathway ⁵²	9.9	TP53, ERBB2, CDKN1A, EGFR
28	Integrated Breast Cancer Pathway³⁷	9.9	EGFR, RAC1, ESR1, TP53
29	Epstein-Barr virus infection²⁹	9.9	HLA-DQB1, HLA-DRB1, HLA-DQA1, CDKN1A, TP53
30	PKC-Theta Pathway⁵¹ Hide members PDGF Pathway⁵¹ ITK and TCR Signaling⁵¹ TCR Signaling⁵¹ Fc-EpsilonRI Pathway⁵¹	9.9	HLA-DQB1, HLA-DRB1, HLA-DQA1, RAC1, PTGS2
31	PI3K-Akt signaling pathway²⁹	9.9	IFNA2, EGFR, CDKN1A, RAC1, TP53
32	Wnt Signaling Pathway³⁷ Hide members DNA damage response (only ATM dependent)³⁷ Wnt Signaling Pathway and Pluripotency³⁷	9.9	CDKN2A, CDKN1A, RAC1, ERBB2, TP53
33	Glioblastoma Multiforme⁵¹	9.8	EGFR, CDKN2A, CDKN1A, RAC1, TP53
34	Endometrial cancer²⁹ Hide members Colorectal cancer²⁹ Signal transduction PTEN pathway¹²	9.8	EGFR, CDKN1A, RAC1, ERBB2, TP53
35	Influenza A²⁹ Hide members Measles²⁹ Herpes simplex infection²⁹	9.8	IFNA2, HLA-DQB1, HLA-DRB1, HLA-DQA1, TAP1, TP53
36	PIP3 activates AKT signaling⁵³ Hide members Signaling by ERBB4⁵³ PI-3K cascade⁵³ Signaling by SCF-KIT⁵³ PI3K events in ERBB2 signaling⁵³ PI3K events in ERBB4 signaling⁵³ GAB1 signalosome⁵³ PI3K/AKT Signaling in Cancer⁵³ Constitutive PI3K/AKT Signaling in Cancer⁵³ PI3K/AKT activation⁵³	9.8	EGFR, CDKN1A, RAC1, ERBB2, ESR1
37	Development Ligand-independent activation of ESR1 and ESR2 Hide members Development Ligand-independent activation of ESR1 and ESR2¹² Transcription PPAR Pathway¹² Transcription CREB pathway¹²	9.8	EGFR, RAC1, PTGS2, ERBB2, ESR1
38	HTLV-I infection²⁹	9.8	HLA-DQB1, HLA-DRB1, HLA-DQA1, CDKN2A, CDKN1A, TP53
39	Actin Nucleation by ARP-WASP Complex⁵¹ Hide members CDC42 Pathway⁵¹ Actin Nucleation and Branching⁵¹	9.8	HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR, RAC1, ERBB2
40	ErbB4 Pathway⁵¹ Hide members ErbB2-ErbB3 Heterodimers⁵¹ ErbB Family Pathway⁵¹ LPS Stimulated MAPK Signaling⁵¹ HMGB1 Pathway⁵¹ PI3K Signaling in B-Lymphocyte⁵¹ UVC-Induced MAPK Signaling⁵¹ IL-4 Pathway⁵¹	9.8	HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR, RAC1, ERBB2
41	GPCR Pathway⁵¹ Hide members Pancreatic Adenocarcinoma⁵¹ Breast Cancer Regulation by Stathmin1⁵¹ Estrogen Pathway⁵¹ P2Y Receptor Signaling⁵¹ Ras Pathway⁵¹ Paxillin Interactions⁵¹ NFAT in Immune Response⁵¹	9.7	TP53, ESR1, ERBB2, HLA-DQA1, HLA-DRB1, HLA-DQB1
42	Chronic myeloid leukemia²⁹ Hide members Pancreatic cancer²⁹	9.7	EGFR, CDKN2A, CDKN1A, RAC1, ERBB2, TP53
43	Immune System⁵³ Hide members Adaptive Immune System⁵³ Innate Immune System⁵³	9.7	IFNA2, HLA-DQB1, HLA-DRB1, HLA-DQA1, EGFR, CDKN1A
44	Proteoglycans in cancer²⁹	9.7	EGFR, CDKN1A, RAC1, ERBB2, ESR1, TP53
45	Rho Family GTPases⁵¹ Hide members Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹ MAPK Signaling⁵¹ ILK Signaling⁵¹	9.7	CDKN1A, RAC1, PTGS2, ERBB2, ESR1, TP53
46	MicroRNAs in cancer²⁹	9.7	EGFR, CDKN2A, CDKN1A, PTGS2, ERBB2, TP53
47	Development HGF signaling pathway¹² Hide members Neurotrophin signaling pathway²⁹ Development Neurotrophin family signaling¹² Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1¹² Development EGFR signaling via small GTPases¹² Apoptosis and survival Role of CDK5 in neuronal death and survival¹² Development EGFR signaling via PIP3¹² Development PDGF signaling via MAPK cascades¹² Renal cell carcinoma²⁹ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)³⁷	9.7	EGFR, RAC1, PTGS2, ERBB2, ESR1, TP53
48	PEDF Induced Signaling⁵¹ Hide members MIF Regulation of Innate Immune Cells⁵¹ Endothelin-1 Signaling Pathway⁵¹ all-trans-Retinoic Acid Signaling in Brain⁵¹ MIF Mediated Glucocorticoid Regulation⁵¹ STAT3 Pathway⁵¹ Glucocorticoid Receptor Signaling⁵¹ Cytokine-cytokine receptor interaction²⁹	9.6	IFNA2, EGFR, CDKN1A, RAC1, PTGS2, ERBB2
49	Pathways in cancer²⁹	9.6	EGFR, CDKN2A, CDKN1A, RAC1, PTGS2, ERBB2
50	Integrated Pancreatic Cancer Pathway³⁷	9.5	EGFR, CDKN1A, RAC1, PTGS2, ERBB2, ESR1

Compounds for genes affiliated with Recurrent Respiratory Papillomatosis

Sources:
⁴⁴Novoseek, ⁵⁹Tocris Bioscience, ¹¹DrugBank, ²⁴HMDB, ⁴⁹PharmGKB, ²⁸IUPHAR, ²BitterDB
See all sources

Compounds related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show top 50) (show all 95)

id	Compound	Score	Top Affiliating Genes
1	resveratrol⁴⁴ ⁵⁹ ¹¹ ²⁴	13.7	ERBB2
2	etoposide⁴⁴ ⁴⁹ ⁵⁹ ¹¹	13.4	IFNA2, UGCG, ERBB2
3	acnu⁴⁴	10.4	TP53, CDKN1A, CDKN2A
4	hrgbeta1⁴⁴	10.4	EGFR, CDKN1A, ERBB2
5	valine⁴⁴	10.4	CDKN2A, TAP1, RAC1, ERBB2
6	bcnu⁴⁴	10.4	IFNA2, EGFR, CDKN2A, TP53
7	megestrol acetate⁴⁴	10.4	IFNA2, ERBB2, ESR1
8	hpvs⁴⁴	10.4	CDKN2A, CDKN1A, TP53
9	tamoxifen⁴⁴ ⁴⁹ ²⁸ ¹¹	13.4	UGCG, EGFR, CDKN1A, ERBB2
10	exemestane⁴⁹ ⁴⁴ ⁵⁹ ¹¹	13.3	ESR1, ERBB2, PTGS2, EGFR
11	temozolomide⁴⁴ ¹¹	11.3	IFNA2, EGFR, CDKN2A, CDKN1A, TP53
12	anastrozole⁴⁴ ¹¹	11.3	ESR1, ERBB2, EGFR
13	suberoylanilide hydroxamic acid⁴⁴	10.3	EGFR, CDKN1A, ERBB2, TP53
14	irinotecan⁴⁴ ⁴⁹ ¹¹	12.3	EGFR, CDKN2A, CDKN1A, ERBB2, TP53
15	oxaliplatin⁴⁴ ⁴⁹ ¹¹	12.3	EGFR, CDKN1A, ERBB2, TP53
16	taxane⁴⁴	10.2	EGFR, CDKN1A, ERBB2, ESR1, TP53
17	flavopiridol⁴⁴ ¹¹	11.2	EGFR, CDKN2A, CDKN1A, ERBB2, TP53
18	3,3-diindolylmethane⁴⁴	10.2	TP53, ESR1, CDKN1A
19	n-(4-hydroxyphenyl)retinamide⁴⁴	10.2	UGCG, CDKN1A, ERBB2, ESR1, TP53
20	lapatinib⁴⁴ ⁴⁹ ¹¹	12.2	ESR1, HLA-DRB1, HLA-DQA1, EGFR, TAP1, ERBB2
21	gefitinib⁴⁴ ⁴⁹ ¹¹	12.2	EGFR, CDKN1A, PTGS2, ERBB2, ESR1
22	gemcitabine⁴⁴ ⁴⁹ ¹¹	12.2	EGFR, CDKN1A, PTGS2, ERBB2, TP53
23	geldanamycin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	13.2	EGFR, CDKN1A, ERBB2, ESR1, TP53
24	celecoxib⁴⁴ ⁵⁹ ²⁸ ⁴⁹ ¹¹ ²⁴	15.2	EGFR, CDKN1A, PTGS2, ERBB2
25	adriamycin⁴⁴	10.2	TP53, ERBB2, CDKN1A, CDKN2A, UGCG
26	thymidylate⁴⁴	10.2	IFNA2, EGFR, CDKN2A, CDKN1A, ERBB2, TP53
27	bortezomib⁴⁴ ¹¹	11.2	TP53, ERBB2, CDKN1A, EGFR
28	carboplatin⁴⁴ ⁴⁹ ¹¹	12.1	IFNA2, EGFR, ERBB2, TP53
29	agar⁴⁴	10.1	IFNA2, EGFR, CDKN2A, CDKN1A, RAC1, ERBB2
30	mg 132⁴⁴ ⁵⁹	11.1	EGFR, CDKN2A, CDKN1A, ESR1, TP53
31	docetaxel⁴⁴ ⁴⁹ ⁵⁹ ¹¹	13.1	EGFR, CDKN2A, CDKN1A, ERBB2, ESR1, TP53
32	curcumin⁴⁴	10.1	EGFR, CDKN1A, PTGS2, ERBB2, TP53
33	tetracycline⁴⁴ ¹¹	11.1	EGFR, CDKN2A, RAC1, ERBB2
34	5fluorouracil⁴⁴	10.0	IFNA2, EGFR, CDKN2A, CDKN1A, ERBB2, ESR1
35	olomoucine⁴⁴ ¹¹	11.0	CDKN2A, CDKN1A, TP53
36	hydroxyurea⁴⁴ ⁴⁹ ¹¹	12.0	TP53, CDKN1A, CDKN2A, IFNA2
37	n acetylcysteine⁴⁴	10.0	EGFR, CDKN2A, CDKN1A, RAC1, PTGS2, ERBB2
38	paraffin⁴⁴	10.0	HLA-DQA1, EGFR, CDKN2A, CDKN1A, ERBB2, ESR1
39	ly294002⁴⁴	9.9	EGFR, CDKN1A, RAC1, PTGS2, ERBB2, ESR1
40	oligonucleotide⁴⁴	9.9	HLA-DQB1, HLA-DRB1, HLA-DQA1, CDKN2A, CDKN1A, TAP1
41	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	14.9	EGFR, CDKN2A, CDKN1A, RAC1, PTGS2, ERBB2
42	retinoid⁴⁴	9.9	IFNA2, EGFR, CDKN1A, ESR1, TP53
43	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	13.9	IFNA2, EGFR, CDKN2A, CDKN1A, ERBB2, ESR1
44	doxorubicin⁴⁴ ⁴⁹ ¹¹	11.9	IFNA2, UGCG, EGFR, CDKN2A, CDKN1A, ERBB2
45	paclitaxel⁴⁴ ⁴⁹ ¹¹	11.9	UGCG, EGFR, CDKN2A, CDKN1A, RAC1, ERBB2
46	toremifene⁴⁴ ¹¹	10.8	IFNA2, ERBB2, ESR1
47	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	12.8	IFNA2, UGCG, EGFR, CDKN2A, CDKN1A, RAC1
48	vegf⁴⁴	9.7	IFNA2, EGFR, CDKN2A, CDKN1A, RAC1, PTGS2
49	retinoic acid⁴⁴ ²⁴	10.7	IFNA2, UGCG, EGFR, CDKN2A, CDKN1A, RAC1
50	arginine⁴⁴	9.6	EXT1, HLA-DRB1, HLA-DQA1, CDKN2A, RAC1, ERBB2

GO Terms for genes affiliated with Recurrent Respiratory Papillomatosis

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.4	HLA-DQB1, HLA-DRB1, HLA-DQA1
2	clathrin-coated endocytic vesicle membrane	GO:030669	10.3	HLA-DQB1, HLA-DRB1, HLA-DQA1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.3	HLA-DQA1, HLA-DRB1, HLA-DQB1
4	transport vesicle membrane	GO:030658	10.2	HLA-DQB1, HLA-DRB1, HLA-DQA1
5	ER to Golgi transport vesicle membrane	GO:012507	10.2	HLA-DQB1, HLA-DRB1, HLA-DQA1
6	endocytic vesicle membrane	GO:030666	10.2	HLA-DQA1, HLA-DRB1, HLA-DQB1
7	trans-Golgi network membrane	GO:032588	10.1	HLA-DQB1, HLA-DRB1, HLA-DQA1
8	membrane	GO:016020	9.8	ESR1, DPM1, EGFR, UGCG, HLA-DRB1, HLA-DQB1
9	endosome membrane	GO:010008	9.7	ERBB2, EGFR, HLA-DQA1, HLA-DQB1
10	Golgi membrane	GO:000139	9.6	FUT8, HS3ST3A1, EXT1, HLA-DQB1, HLA-DRB1, HLA-DQA1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.5	HLA-DQB1, HLA-DRB1
2	negative regulation of immature T cell proliferation in thymus	GO:033088	10.5	CDKN2A, ERBB2
3	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.4	HLA-DRB1, HLA-DQB1
4	interferon-gamma-mediated signaling pathway	GO:060333	10.4	HLA-DQB1, HLA-DRB1, HLA-DQA1
5	T cell costimulation	GO:031295	10.4	RAC1, HLA-DQA1, HLA-DRB1, HLA-DQB1
6	positive regulation of fibroblast proliferation	GO:048146	10.3	ESR1, CDKN1A, EGFR
7	positive regulation of nitric oxide biosynthetic process	GO:045429	10.3	EGFR, PTGS2, ESR1
8	mitotic cell cycle arrest	GO:071850	10.3	TP53, CDKN1A
9	cytokine-mediated signaling pathway	GO:019221	10.3	HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNA2
10	negative regulation of gene expression	GO:010629	10.3	ESR1, CDKN1A, IFNA2
11	Fc-epsilon receptor signaling pathway	GO:038095	10.2	ERBB2, RAC1, CDKN1A, EGFR
12	replicative senescence	GO:090399	10.2	CDKN2A, TP53
13	Ras protein signal transduction	GO:007265	10.2	CDKN2A, CDKN1A, TP53
14	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	10.2	HLA-DQA1, HLA-DRB1, HLA-DQB1
15	T cell receptor signaling pathway	GO:050852	10.1	HLA-DQA1, HLA-DRB1, HLA-DQB1
16	neurotrophin TRK receptor signaling pathway	GO:048011	9.7	EGFR, CDKN1A, RAC1, ERBB2

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards/GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.3	HLA-DQA1, HLA-DRB1, HLA-DQB1
2	epidermal growth factor-activated receptor activity	GO:005006	10.3	ERBB2, EGFR
3	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:004861	10.2	CDKN1A, CDKN2A
4	MDM2/MDM4 family protein binding	GO:097371	10.2	TP53, CDKN2A
5	nitric-oxide synthase regulator activity	GO:030235	10.1	EGFR, ESR1
6	enzyme binding	GO:019899	9.9	EGFR, RAC1, PTGS2, ESR1, TP53
7	protein heterodimerization activity	GO:046982	9.9	EXT1, HEXB, EGFR, ERBB2, TP53
8	receptor signaling protein tyrosine kinase activity	GO:004716	9.9	ERBB2, EGFR